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Optic neuropathy

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https://www.readbyqxmd.com/read/28334035/early-inner-retinal-thinning-and-cardiovascular-autonomic-dysfunction-in-type-2-diabetes
#1
Jin A Choi, Hyo Won Kim, Jin-Woo Kwon, Yun-Sub Shim, Dong Hyun Jee, Jae-Seung Yun, Yu-Bae Ahn, Chan Kee Park, Seung-Hyun Ko
BACKGROUND: To investigate changes in the neural retina according to the presence of retinal nerve fiber layer (RNFL) defects in type 2 diabetes, and to determine the association between inner retina thickness and the severity of diabetic complications. METHODS: We studied non-glaucomatous patients with type 2 diabetes and control subjects Circumpapillary RNFL and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses were measured by spectral-domain optical coherence tomography...
2017: PloS One
https://www.readbyqxmd.com/read/28333890/the-association-between-clinical-features-seen-on-fundus-photographs-and-glaucomatous-damage-detected-on-visual-fields-and-optical-coherence-tomography-scans
#2
Paula A Alhadeff, Carlos G De Moraes, Monica Chen, Ali S Raza, Robert Ritch, Donald C Hood
PURPOSE: To classify the appearance of the optic disc seen on fundus photographs of healthy subjects and patients with or suspected glaucoma whose diagnosis was based upon visual fields (VFs) and spectral-domain optical coherence tomography (sdOCT) results. PATIENTS AND METHODS: One eye of 100 patients with or suspected glaucoma and 62 healthy subjects were prospectively tested with 24-2 and 10-2 VF and macular and disc sdOCT cube scans. All eyes with or suspected glaucoma had a 24-2 mean deviation better than -6...
March 22, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28333176/efficacy-of-retrobulbar-hyaluronidase-injection-for-vision-loss-resulting-from-hyaluronic-acid-filler-embolization
#3
Guo-Zhang Zhu, Zhong-Sheng Sun, Wen-Xiong Liao, Bing Cai, Chun-Lin Chen, Hui-Hui Zheng, Li Zeng, Sheng-Kang Luo
Background: Vision loss is a rare but serious complication of facial hyaluronic acid (HA) filler injection, for which there is no proven rescue therapy. Retrobulbar hyaluronidase injection is advocated by many plastic surgeons as an emergency treatment, but has not been carefully assessed for its efficacy. Objectives: To evaluate the efficacy of retrobulbar hyaluronidase injection as a rescue treatment for vision loss caused by HA filler embolization. Methods: Patients with vision loss caused by HA filler embolization were treated with retrobulbar hyaluronidase injection...
January 20, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/28331457/visual-loss-retinal-hemorrhages-and-optic-disc-edema-resulting-from-thiamine-deficiency-following-bariatric-surgery-complicated-by-prolonged-vomiting
#4
Andrew W Lawton, Nicholas E Frisard
BACKGROUND: Vision loss resulting from thiamine deficiency is a recognized complication of bariatric surgery. Most patients with such vision loss have Wernicke encephalopathy with characteristic changes seen on neuroimaging. Other patients may have retinal hemorrhages, optic disc edema, and peripheral neuropathy without Wernicke encephalopathy. The risk for thiamine deficiency is potentiated by the presence of prolonged vomiting. CASE REPORT: A 37-year-old female presented with abrupt onset of vision loss and peripheral neuropathy following bariatric surgery...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28329893/graves-ophthalmopathy-in-a-paediatric-population
#5
Y Sadeghi, A Obéric, G Theintz, M Hamédani
Background Graves' disease is an autoimmune disorder leading to hyperthyroidism. It is often associated with ophthalmic manifestations. Graves' disease is reported to be rare in the paediatric population. Patients and Methods We performed a retrospective analysis on all patients diagnosed with ophthalmopathy related to Graves' disease at a paediatric age (less than 18 years old) in our institution between 2004 and 2015. Results Eight patients were identified: 6 females and 2 males. The median age at diagnosis was 11...
March 22, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28324977/a-novel-method-to-assess-angle-sensor-performance-for-wearable-exoskeletal-joint-kinematics
#6
Nicholas B Bolus, Geza F Kogler, Omer T Inan
Full range of motion (ROM) at a joint is necessary for efficient and adaptive movement; as such, it is an essential clinical evaluation measure for assessing an individual's motor function, which can be affected by any number of musculoskeletal injuries and neuropathies. Measurement of joint ROM in the clinic has classically been accomplished statically through the use of a manual goniometer. More recent efforts in the fields of prosthetics and orthotics have demonstrated the potential utility of wearable systems (e...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28323869/tyrosine-mutated-aav2-mediated-shrna-silencing-of-pten-promotes-axon-regeneration-of-adult-optic-nerve
#7
ZhengRu Huang, ZiZhong Hu, Ping Xie, QingHuai Liu
Activating PI3K/AKT/mTOR signaling pathway via deleting phosphatase and tensin homolog (PTEN) has been confirmed to enhance intrinsic growth capacity of neurons to facilitate the axons regeneration of central nervous system after injury. Considering conditional gene deletion is currently not available in clinical practice, we exploited capsid residue tyrosine 444 to phenylalanine mutated single-stranded adeno-associated virus serotype 2 (AAV2) as a vector delivering short hairpin RNA to silence PTEN to promote retinal ganglion cells (RGCs) survival and axons regeneration in adult rat optic nerve axotomy paradigm...
2017: PloS One
https://www.readbyqxmd.com/read/28321515/isolated-optic-neuritis-associated-with-mycoplasma-pneumoniae-infection-report-of-two-cases-and-literature-review
#8
Seo-Young Choi, You-Jin Choi, Jae-Hwan Choi, Kwang-Dong Choi
Mycoplasma pneumonia is a major pathogen of primary atypical pneumonia and has been known to cause various kinds of extrapulmonary manifestations involving almost all organs of the human body. Optic neuritis associated with M. pneumoniae infection has rarely been described and mostly, it combined other neurological complications including meningitis, meningoencephalitis, myelitis, and peripheral neuropathy. We report two patients who presented with isolated optic neuritis due to M. pneumoniae infection, and reviewed the literatures on five additional patients...
March 20, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28320183/ischemic-optic-neuropathy-as-a-model-of-neurodegenerative-disorder-a-review-of-pathogenic-mechanism-of-axonal-degeneration-and-the-role-of-neuroprotection
#9
REVIEW
Saba Khalilpour, Shahrzad Latifi, Ghazaleh Behnammanesh, Amin Malik Shah Abdul Majid, Aman Shah Abdul Majid, Ali Tamayol
Optic neuropathy is a neurodegenerative disease which involves optic nerve injury. It is caused by acute or intermittent insults leading to visual dysfunction. There are number of factors, responsible for optic neuropathy, and the optic nerve axon is affected in all type which causes the loss of retinal ganglion cells. In this review we will highlight various mechanisms involved in the cell loss cascades during axonal degeneration as well as ischemic optic neuropathy. These mechanisms include oxidative stress, excitotoxicity, angiogenesis, neuroinflammation and apoptosis following retinal ischemia...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28316838/retinal-vessel-density-in-optical-coherence-tomography-angiography-in-optic-atrophy-after-nonarteritic-anterior-ischemic-optic-neuropathy
#10
Chun-Hsiu Liu, Ling-Yuh Kao, Ming-Hui Sun, Wei-Chi Wu, Henry Shen-Lih Chen
Aims. To compare optical coherence tomography angiography (OCT-A) retinal vasculature measurements between normal and optic atrophy after nonarteritic anterior ischemic optic neuropathy (NAION) subjects. Design. This prospective observational study was conducted between July 2015 and August 2016 at the ophthalmology outpatient department of a referral center in Taiwan. Peripapillary (4.5 × 4.5 mm) and parafoveal (6 × 6 mm) OCT-A scans were acquired. Measurements of the peripapillary region were obtained in two areas: (1) circumpapillary vessel density (cpVD) and (2) whole enface image vessel density (wiVD)...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28315279/the-role-of-sigma-1-receptor-as-a-neuroprotective-target-in-glaucoma
#11
Barbara Mysona, Neil Kansara, Jing Zhao, Kathryn Bollinger
The role of sigma 1 receptor (S1R) in glaucoma is emerging as a promising field of study. Glaucoma is an optic neuropathy that shares common pathogenic mechanisms with other neurodegenerative diseases such as Alzheimer's and Parkinson's disease . S1R modulates multiple cellular functions associated with neurodegeneration . These include Ca(2+) ion homeostasis, endoplasmic reticulum (ER) and oxidative stress , survival signaling pathways, neurotrophin secretion, and glial activation. S1R may also have neurorestorative properties including enhancement of neuronal plasticity and neurite outgrowth...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28314831/childhood-onset-leber-hereditary-optic-neuropathy
#12
Anna Majander, Richard Bowman, Joanna Poulton, Richard J Antcliff, M Ashwin Reddy, Michel Michaelides, Andrew R Webster, Patrick F Chinnery, Marcela Votruba, Anthony T Moore, Patrick Yu-Wai-Man
BACKGROUND: The onset of Leber hereditary optic neuropathy (LHON) is relatively rare in childhood. This study describes the clinical and molecular genetic features observed in this specific LHON subgroup. METHODS: Our retrospective study consisted of a UK paediatric LHON cohort of 27 patients and 69 additional cases identified from a systematic review of the literature. Patients were included if visual loss occurred at the age of 12 years or younger with a confirmed pathogenic mitochondrial DNA mutation: m...
March 17, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28303068/high-dose-intravenous-pulse-steroid-therapy-for-optic-disc-swelling-and-subretinal-fluid-in-non-arteritic-anterior-ischemic-optic-neuropathy
#13
Kei Takayama, Hiroki Kaneko, Shu Kachi, Eimei Ra, Yasuki Ito, Hiroko Terasaki
Non-arteritic anterior ischemic optic neuropathy (NAION) is a disease with microvascular abnormality that causes acute optic disc swelling (ODS) and, in severe cases, subretinal fluid (SRF) accumulation. ODS causes compartment syndrome and subsequent axonal degeneration and loss of retinal ganglion cells by apoptosis. No treatment modalities have been effective, although some cases improved after the intake of oral systemic steroids. We reported a case of a 72-year-old man who was referred due to a visual defect in the right eye...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28302535/aqueous-humor-cytokines-in-patients-with-acute-non-arteritic-anterior-ischemic-optic-neuropathy-naion
#14
Jonathan A Micieli, Cindy Lam, Kinda Najem, Edward A Margolin
PURPOSE: To measure and compare the cytokine concentrations in the aqueous humor of patients with acute non-arteritic anterior ischemic optic neuropathy (NAION) and normal age-related cataract controls. DESIGN: Prospective, comparative observational study. METHODS: Aqueous humor samples were obtained in 10 patients with acute NAION (within 14 days of symptom onset) and 15 control patients with age-related cataract. The levels of 6 cytokines [vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-2, IL-6, and IL-8] were determined using a multiplex bead immunoassay...
March 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28301863/optical-coherence-tomography-angiography-in-nonarteritic-anterior-ischemic-optic-neuropathy
#15
Emily Wright Mayes, Emily D Cole, Sabin Dang, Eduardo A Novais, Laurel Vuong, Carlos Mendoza-Santiesteban, Jay S Duker, Thomas R Hedges
BACKGROUND: Optical coherence tomography angiography (OCTA) has demonstrated good utility in qualitative analysis of retinal and choroidal vasculature and therefore may be relevant in the diagnostic and treatment efforts surrounding nonarteritic anterior ischemic optic neuropathy (NAION). METHODS: Retrospective, cross-sectional study of 10 eyes of 9 patients with a previous or new diagnosis of NAION that received imaging with OCTA between November 2015 and February 2016...
March 15, 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28301411/retinal-phenotype-in-a-case-of-lchad-tfp-deficiency-with-late-stage-diagnosis
#16
Jacob A Knowles, Ioannis S Dimopoulos, Ian M MacDonald
PURPOSE: To report the retinal phenotype of a rare case of long-chain 3-hydroxyacyl-CoA dehydrogenase (LCHAD)/trifunctional protein (TFP) deficiency diagnosed in his late 40s with ocular findings of diffuse chorioretinal atrophy and bilateral retinoschisis. METHODS: An acylcarnitine profile assay revealed LCHAD/TFP deficiency in a 45-year-old man with a history of high myopia, bilateral decreased vision, episodic rhabdomyolysis, and peripheral neuropathy. Ocular findings were evaluated with spectral domain optical coherence tomography (Spectralis OCT; Heidelberg Engineering, Heidelberg, Germany) and color fundus photography...
March 15, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28300644/the-connective-tissue-phenotype-of-glaucomatous-cupping-in-the-monkey-eye-clinical-and-research-implications
#17
REVIEW
Hongli Yang, Juan Reynaud, Howard Lockwood, Galen Williams, Christy Hardin, Luke Reyes, Cheri Stowell, Stuart K Gardiner, Claude F Burgoyne
In a series of previous publications we have proposed a framework for conceptualizing the optic nerve head (ONH) as a biomechanical structure. That framework proposes important roles for intraocular pressure (IOP), IOP-related stress and strain, cerebrospinal fluid pressure (CSFp), systemic and ocular determinants of blood flow, inflammation, auto-immunity, genetics, and other non-IOP related risk factors in the physiology of ONH aging and the pathophysiology of glaucomatous damage to the ONH. The present report summarizes 20 years of technique development and study results pertinent to the characterization of ONH connective tissue deformation and remodeling in the unilateral monkey experimental glaucoma (EG) model...
March 12, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28299012/optical-coherence-tomography-angiography-of-the-optic-disc-an-overview
#18
REVIEW
Handan Akil, Khalil Ghasemi Falavarjani, Srinivas R Sadda, Alfredo A Sadun
Different diseases of the optic disc may be caused by or lead to abnormal vasculature at the optic nerve head. Optical coherence tomography angiography (OCTA) is a novel technology that provides high resolution mapping of the retinal and optic disc vessels. Recent studies have shown the ability of OCTA to visualize vascular abnormalities in different optic neuropathies. In addition, quantified OCTA measurements were found promising for differentiating optic neuropathies from healthy eyes.
January 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28298852/leber-s-hereditary-optic-neuropathy-report-of-a-simple-case-associated-with-a-rare-variant-mutation
#19
Ravinder Mohan Malhotra, Mousa Ali Al Mejally, Hanadi Mahmoud Abualela, Marwa Ahmed Eltemamy
No abstract text is available yet for this article.
January 2017: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/28297028/early-methylprednisolone-treatment-can-stabilize-the-blood-optic-nerve-barrier-in-a-rat-model-of-anterior-ischemic-optic-neuropathy-raion
#20
Tzu-Lun Huang, Yao-Tseng Wen, Chung-Hsing Chang, Shu-Wen Chang, Kuan-Hung Lin, Rong-Kung Tsai
Purpose: We investigated whether methylprednisolone (MP) treatment halting retinal ganglion cell (RGC) death and having anti-inflammatory effect over a narrow therapeutic window affects the integrity of the blood-optic nerve barrier (BOB) in a rat model of ischemic optic neuropathy (rAION). Methods: The optic nerve (ON) vascular permeability was determined by Evans blue extravasation. Changes in the levels of TNF-α and IL-1β cytokines were analyzed using quantitative RT-PCR (qRT-PCR) from day 1 to day 5 post-rAION...
March 1, 2017: Investigative Ophthalmology & Visual Science
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