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Optic neuropathy

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https://www.readbyqxmd.com/read/28228830/optic-disc-and-macular-imaging-in-blind-eyes-from-non-glaucomatous-optic-neuropathy-a-study-with-spectral-domain-optical-coherence-tomography
#1
Linda Hansapinyo, Andy C O Cheng, Noel C Y Chan, Carmen K M Chan
The purpose of this study was to determine and compare the optic disc and macular thickness measurements using two spectral-domain optical coherence tomography (SD-OCT) instruments in long-standing blind eyes diagnosed with non-glaucomatous optic neuropathies (NGON). A prospective observational case-series design was used. Twelve eyes from 12 NGON patients with no light perception for at least 6 months underwent optic disc and macular imaging with Cirrus HD-OCT and Spectralis OCT. The correlation between the peripapillary retinal nerve fibre layer (PRNFL) and macular ganglion cell layer and inner plexiform layer (GCL+IPL) thicknesses, and between the duration of no light perception (NLP) and PRNFL/GCL+IPL thicknesses were determined using Spearman's correlation analysis...
February 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/28227176/a-novel-method-to-assess-angle-sensor-performance-for-wearable-exoskeletal-joint-kinematics
#2
Nicholas B Bolus, Geza F Kogler, Omer T Inan, Nicholas B Bolus, Geza F Kogler, Omer T Inan, Geza F Kogler, Omer T Inan, Nicholas B Bolus
Full range of motion (ROM) at a joint is necessary for efficient and adaptive movement; as such, it is an essential clinical evaluation measure for assessing an individual's motor function, which can be affected by any number of musculoskeletal injuries and neuropathies. Measurement of joint ROM in the clinic has classically been accomplished statically through the use of a manual goniometer. More recent efforts in the fields of prosthetics and orthotics have demonstrated the potential utility of wearable systems (e...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28223915/oral-delivery-of-a-synthetic-sterol-reduces-axonopathy-and-inflammation-in-a-rodent-model-of-glaucoma
#3
Wendi S Lambert, Brian J Carlson, Cathryn R Formichella, Rebecca M Sappington, Clarence Ahlem, David J Calkins
Glaucoma is a group of optic neuropathies associated with aging and sensitivity to intraocular pressure (IOP). The disease is the leading cause of irreversible blindness worldwide. Early progression in glaucoma involves dysfunction of retinal ganglion cell (RGC) axons, which comprise the optic nerve. Deficits in anterograde transport along RGC axons to central visual structures precede outright degeneration, and preventing these deficits is efficacious at abating subsequent progression. HE3286 is a synthetic sterol derivative that has shown therapeutic promise in models of inflammatory disease and neurodegenerative disease...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28210901/transplantation-of-lineage-negative-stem-cells-in-pterygopalatine-artery-ligation-induced-retinal-ischemia-reperfusion-injury-in-mice
#4
Gillipsie Minhas, Sudesh Prabhakar, Ryuichi Morishita, Munehisa Shimamura, Reema Bansal, Akshay Anand
Retinal ischemia is a condition associated with retinal degenerative diseases such as glaucoma, diabetic retinopathy, and other optic neuropathies, leading to visual impairment and blindness worldwide. Currently, there is no therapy available for ischemic retinopathies. Therefore, the aim of this study was to test a murine model of pterygopalatine artery ligation-induced retinal injury for transplantation of mouse bone marrow-derived lineage-negative (lin-ve) stem cells. The mouse external carotid artery and pterygopalatine artery were ligated for 3...
February 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28198592/bone-marrow-derived-mesenchymal-stem-cells-derived-exosomes-promote-survival-of-retinal-ganglion-cells-through-mirna-dependent-mechanisms
#5
Ben Mead, Stanislav Tomarev
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30-100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells...
February 15, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28196731/natural-history-of-conversion-of-leber-s-hereditary-optic-neuropathy-a-prospective-case-series
#6
Tiffany Jean Hwang, Rustum Karanjia, Milton Nunes Moraes-Filho, Jesse Gale, Jeffrey Show Tran, Edward R Chu, Solange R Salomao, Adriana Berezovsky, Rubens Belfort, Milton Nunes Moraes, Federico Sadun, Anna Maria DeNegri, Chiara La Morgia, Piero Barboni, Carolina do V F Ramos, Carlos Filipe Chicani, Peter A Quiros, Valerio Carelli, Alfredo A Sadun
PURPOSE: To illustrate the natural history of Leber's hereditary optic neuropathy (LHON). DESIGN: Prospective observational case series. PARTICIPANTS: The Soave-Brazil pedigree of m.11778G>A/ND4 mitochondrial DNA LHON mutation. METHODS: A prospectively acquired database of the Soave-Brazil pedigree was reviewed. Data from 285 individuals were included in the database over a 15-year period. The pedigree was reviewed for unaffected mutation carriers who converted to affected status, 6 patients with LHON were identified...
February 10, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28192386/spectrum-of-magnetic-resonance-imaging-features-in-unilateral-optic-tract-dysfunction
#7
Kristopher M Kowal, Francisco F Rivas Rodriguez, Ashok Srinivasan, Jonathan D Trobe
BACKGROUND: Optic tract dysfunction may be the predominant or only clinical manifestation of an intracranial disorder including mass legion, ischemic infarct, inflammatory disease, and trauma. Documentation of the neuroimaging features of these lesions is limited to reports mostly published before the availability of MRI. This study was undertaken to document the spectrum of MRI features in patients presenting with optic tract dysfunction. METHODS: A retrospective study from 2004 to 2015 at a single tertiary care neuro-ophthalmology service of 24 patients who had unilateral optic tract dysfunction defined by a homonymous hemianopia and a relative afferent pupil defect that could not be attributed to optic neuropathy or retinopathy...
March 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28187873/-erratum-to-traumatic-optic-neuropathy-report-of-8%C3%A2-cases-and-review-of-the-literature-j-fr-ophtalmol-39-7-2016-603-8
#8
A Le Guern, C Marks-Delesalle, L Borry, J Chekroun, C Ciocanea, C Gruchala, L Gogneaux, A Lossouarn, J-G Mery, L Nielloud, V Vasseur, S Defoort-Dhelemmes
No abstract text is available yet for this article.
February 7, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28187079/invited-commentary-ganglion-cell-complex-measurement-in-compressive-optic-neuropathy
#9
Jonathan C Horton
No abstract text is available yet for this article.
March 2017: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/28186701/bone-marrow-derived-mesenchymal-stem-cells-derived-exosomes-promote-survival-of-retinal-ganglion-cells-through-mirna-dependent-mechanisms
#10
Ben Mead, Stanislav Tomarev
The loss of retinal ganglion cells (RGC) and their axons is one of the leading causes of blindness and includes traumatic (optic neuropathy) and degenerative (glaucoma) eye diseases. Although no clinical therapies are in use, mesenchymal stem cells (MSC) have demonstrated significant neuroprotective and axogenic effects on RGC in both of the aforementioned models. Recent evidence has shown that MSC secrete exosomes, membrane enclosed vesicles (30-100 nm) containing proteins, mRNA and miRNA which can be delivered to nearby cells...
January 26, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28186610/-progress-in-research-on-pathogenic-genes-and-gene-therapy-for-inherited-retinal-diseases
#11
Ling Zhu, Cong Cao, Jiji Sun, Tao Gao, Xiaoyang Liang, Zhipeng Nie, Yanchun Ji, Pingping Jiang, Minxin Guan
Inherited retinal diseases (IRDs), including retinitis pigmentosa, Usher syndrome, Cone-Rod degenerations, inherited macular dystrophy, Leber's congenital amaurosis, Leber's hereditary optic neuropathy are the most common and severe types of hereditary ocular diseases. So far more than 200 pathogenic genes have been identified. With the growing knowledge of the genetics and mechanisms of IRDs, a number of gene therapeutic strategies have been developed in the laboratory or even entered clinical trials. Here the progress of IRD research on the pathogenic genes and therapeutic strategies, particularly gene therapy, are reviewed...
February 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28185649/treatment-by-rituximab-on-six-grave-s-ophthalmopathies-resistant-to-corticosteroids
#12
Flavien Précausta, Sophie Arsène, Peggy Renoult-Pierre, Boris Laure, Lise Crinière, Pierre-Jean Pisella
OBJECTIVES: Graves' ophthalmopathy occurs in 50% of Graves' disease cases. Treatment is based on smoking cessation, and control of the euthyroidism and ocular repercussions associated with the disease. The active orbital forms are treated with glucocorticoids. Non-validated therapies have also been recently tested. Rituximab has been effectively used several times to treat corticosteroid-resistant Graves' ophthalmopathy associated with an optic neuropathy, but its use could be proposed only in inflammatory ophthalmopathies after failure of the corticosteroids...
February 6, 2017: Annales D'endocrinologie
https://www.readbyqxmd.com/read/28182175/diverse-clinical-signs-of-ocular-involvement-in-cat-scratch-disease
#13
Merih Oray, Sumru Önal, Aylin Koç Akbay, İlknur Tuğal Tutkun
OBJECTIVES: To describe ocular manifestations, diagnosis, and treatment of cat scratch disease. MATERIALS AND METHODS: Clinical records of patients with ocular cat scratch disease were reviewed. RESULTS: Thirteen eyes of 10 patients (7 female, 3 male) with a mean age of 26.9±18.5 years were included. Nine patients had a history of cat contact and had systemic symptoms associated with cat scratch disease 2-90 days prior to the ocular symptoms...
January 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28181909/visual-evoked-potentials-in-diagnostics-of-optic-neuropathy-associated-with-renal-failure
#14
Małgorzata Jurys, Sebastian Sirek, Aureliusz Kolonko, Dorota Pojda-Wilczek
Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60‑100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. It is associated with visual deterioration and reduction in quality of life. Symptoms of the optic neuropathy may appear either before or after dialysis therapy. They often worsen after renal transplant, probably due to immunosuppressive regimen...
January 22, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/28181362/risk-factors-for-radiation-induced-optic-neuropathy-a-case-control-study
#15
Ian Ferguson, Julie Huecker, Jiayi Huang, Collin McClelland, Gregory Van Stavern
IMPORTANCE: Identifying risk factors for RION could promote a more conservative approach to radiation treatment planning in vulnerable patients. BACKGROUND: This study explored possible factors beyond radiation dose associated with the development of radiation-induced optic neuropathy (RION) after external beam radiation therapy. DESIGN: This was a retrospective case-control study conducted at a university hospital tertiary care center. PARTICIPANTS: Cases (n = 14) meeting criteria for a diagnosis of RION by neuro- ophthalmologic exam were identified from a single-center neuro-ophthalmology database...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28180039/endoscopic-endonasal-optic-nerve-decompression-for-fibrous-dysplasia
#16
Timothy R DeKlotz, S Tonya Stefko, Juan C Fernandez-Miranda, Paul A Gardner, Carl H Snyderman, Eric W Wang
Objective To evaluate visual outcomes and potential complications for optic nerve decompression using an endoscopic endonasal approach (EEA) for fibrous dysplasia. Design Retrospective chart review of patients with fibrous dysplasia causing extrinsic compression of the canalicular segment of the optic nerve that underwent an endoscopic endonasal optic nerve decompression at the University of Pittsburgh Medical Center from 2010 to 2013. Main Outcome Measures The primary outcome measure assessed was best-corrected visual acuity (BCVA) with secondary outcomes, including visual field testing, color vision, and complications associated with the intervention...
February 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28171867/analysis-of-the-interleukin-6-174-locus-polymorphism-and-serum-il-6-levels-with-the-severity-of-normal-tension-glaucoma
#17
Ching-Yu Wang, Chiao-Ying Liang, Shih-Chao Feng, Keng-Hung Lin, Hsin-Nung Lee, Ying-Cheng Shen, Li-Chen Wei, Chia-Jen Chang, Min-Yen Hsu, Yi-Yin Yang, Chun-Hung Chiu, Chun-Yuan Wang
PURPOSE: In normal tension glaucoma (NTG), factors other than elevated intraocular pressure are likely to have a role in the pathogenesis of optic neuropathy. Recent studies of glaucoma or retinal ganglion cells (RGCs) reveal that the cytokine interleukin-6 (IL-6) is linked to the pathogenesis of glaucoma and may regulate RGC survival or death. The IL-6 (-174) G allele has also been shown to increase the IL-6 protein. We hypothesized that the IL-6 (-174) polymorphism may be a predisposing genetic factor affecting the severity of glaucoma...
February 8, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/28164440/effect-of-human-umbilical-cord-blood-mesenchymal-stem-cells-administered-by-intravenous-or-intravitreal-routes-on-cryo-induced-retinal-injury
#18
Eman M Mohamed, Shaimaa A Abdelrahman, Samia Hussein, Sally M Shalaby, Hala Mosaad, Ahmed M B Awad
Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure, apoptotic, antiapoptotic, oxidant and antioxidant markers in an experimental model of cryo-induced retinal damage in mice. Forty-eight mice were included with 4 major groups; group I contained 18 mice as controls...
February 5, 2017: IUBMB Life
https://www.readbyqxmd.com/read/28144738/-transorbital-alternating-current-in-optic-neuropathy-december-2016-opinion-of-the-dog-and-bva-on-gall%C3%A2-c-et%C3%A2-al-alternating-current-stimulation-for-vision-restoration-after-optic-nerve-damage-a%C3%A2-randomized-clinical-trial-plos-one-2016
#19
(no author information available yet)
No abstract text is available yet for this article.
January 31, 2017: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/28142161/leber-s-hereditary-optic-neuropathy-normal-tension-glaucoma-and-flammer-syndrome-long-term-follow-up-of-a-patient
#20
K Konieczka, J Flammer, J Sternbuch, T Binggeli, S Fraenkl
No abstract text is available yet for this article.
January 31, 2017: Klinische Monatsblätter Für Augenheilkunde
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