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Optic neuropathy

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https://www.readbyqxmd.com/read/28632028/the-effect-of-combined-systemic-erythropoietin-and-steroid-on-non-arteritic-anterior-ischemic-optic-neuropathy-a-prospective-study
#1
Mohammad Pakravan, Hamed Esfandiari, Kiana Hassanpour, Sarvnaz Razavi, Parastou Pakravan
BACKGROUND: To investigate the effect of combined intravenous (IV) erythropoietin (EPO) and corticosteroid as well as systemic steroid alone for the treatment of non-arteritic anterior ischemic optic neuropathy (NAION). METHODS: In this prospective interventional comparative case series, 113 consecutive patients diagnosed with recent onset (less than 14 days) NAION were included. Patients were categorized into three groups. 40 patients received systemic IV corticosteroid combined with recombinant human erythropoietin (rhEPO) (group 1), 43 patients received systemic corticosteroid alone (group 2), and 30 patients were enrolled as the control group (group 3)...
February 26, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28630249/bilateral-ischaemic-optic-neuropathy-and-retinopathy-along-with-cortical-infarct-in-a-case-of-takayasu-disease
#2
Nripen Gaur, Pradeep Sharma, Brijesh Takkar, Jagjeet Singh
No abstract text is available yet for this article.
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28630220/beyond-cervical-lipomas-myoclonus-gait-disorder-and-multisystem-involvement-leading-to-mitochondrial-disease
#3
Roberto López-Blanco, Ana Rojo-Sebastián, Maria Henedina Torregrosa-Martínez, Alberto Blazquez
Madelung's disease (benign symmetric lipomatosis) is a rare syndrome in which there are multiple lipomas around the neck, upper limbs and trunk in the context of chronic alcoholism. We report on a female patient with lipomas and slightly progressive myoclonus, neuropathy, myopathy, ataxia and respiratory systemic involvement (labelled in the past as Madelung's disease). Multisystem involvement and family history of lipomas led to the development of mitochondrial genetic tests, which can assess two concurrent mitochondrial mutations: the m...
June 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28629926/different-functional-susceptibilities-of-mouse-retinal-ganglion-cell-subtypes-to-optic-nerve-crush-injury
#4
Zhen Puyang, Hai-Qing Gong, Shi-Gang He, John B Troy, Xiaorong Liu, Pei-Ji Liang
In optic neuropathies, the progressive deterioration of retinal ganglion cell (RGC) function leads to irreversible vision loss. Increasing experimental evidence suggests differing susceptibility for RGC functional subtypes. Here with multi-electrode array recordings, RGC functional loss was characterized at multiple time points in a mouse model of optic nerve crush. Firing rate, latency of response and receptive field size were analyzed for ON, OFF and ON-OFF RGCs separately. It was observed that responses and receptive fields of OFF cells were impaired earlier than ON cells after the injury...
June 16, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28626415/a-case-of-childhood-onset-giant-cell-tumor-that-caused-optic-nerve-atrophy-in-both-eyes
#5
Masahiro Tonari, Junko Matsuo, Hidehiro Oku, Jun Sugasawa, Tsunehiko Ikeda, Kazunori Tatsuzawa, Tomoaki Fujita
PURPOSE: The purpose of this study was to report the case of a female patient who had a giant cell tumor in the paranasal sinus during childhood, and while undergoing multiple resection surgeries experienced optic atrophy in both eyes. CASE PRESENTATION: This study involved a 35-year-old woman who was previously diagnosed with a giant cell tumor of the paranasal sinus bone at age 13. A CT scan revealed a large tumor extending from the sphenoid sinus to the ethmoid sinus...
May 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28620702/optic-neuropathy-due-to-nutritional-deficiency-in-a-male-adolescent-with-avoidant-restrictive-food-intake-disorder-a-case-report
#6
Francesca Chiarello, Elisa Marini, Andrea Ballerini, Valdo Ricca
No abstract text is available yet for this article.
June 15, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28619499/results-of-early-high-flow-bypass-and-trapping-for-ruptured-blood-blister-like-aneurysms-of-the-internal-carotid-artery
#7
Yuichiro Kikkawa, Toshiki Ikeda, Ririko Takeda, Hiroyuki Nakajima, Takeshi Ogura, Hidetoshi Ooigawa, Hiroki Kurita
OBJECTIVE: The aim of this study is to clarify the efficacy and safety of early surgery using trapping of the affected internal carotid artery (ICA) and high-flow bypass between second portion of the middle cerebral artery and cervical external carotid artery with radial artery graft for ruptured blood blister-like aneurysms (BBAs) arising from anterior wall of the ICA. METHODS: Medical chart of consecutive 16 patients (M:F=7:9, mean 59 years) with subarachnoid hemorrhage (WFNS grade I:2, II:5, III:2, IV:4, V:3) due to ruptured BBA surgically treated between July 2010 and October 2015 were retrospectively reviewed...
June 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28611648/complete-recovery-from-blindness-in-case-of-compressive-optic-neuropathy-due-to-unruptured-anterior-cerebral-artery-aneurysm
#8
Yurie Fukiyama, Hidehiro Oku, Yusuke Hashimoto, Yuko Nishikawa, Masahiro Tonari, Jun Sugasawa, Shigeru Miyachi, Tsunehiko Ikeda
It is not common for an isolated visual symptom to be the first indication of an aneurysm compressing the optic nerve. The compression can lead to blindness, and a recovery from the blindness is rare. We report a female with a left painless optic neuropathy caused by an unruptured anterior cerebral artery aneurysm. The patient had a temporal hemianopic visual field defect, which progressed to blindness in the left eye, while the right visual function was not affected. A coil embolization of the aneurysm completely restored her visual acuity to 20/20...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28608186/incidence-of-glaucomatous-visual-field-loss-after-two-decades-of-follow-up-the-rotterdam-study
#9
Henriët Springelkamp, Roger C Wolfs, Wishal D Ramdas, Albert Hofman, Johannes R Vingerling, Caroline C Klaver, Nomdo M Jansonius
To determine the incidence of glaucomatous visual field loss (GVFL) two decades after the start of the Rotterdam Study, and to compare known risk factors for open-angle glaucoma (OAG) between different clinical manifestations of OAG. Of 6806 participants aged 55 years and older from the population-based Rotterdam Study, 3939 underwent visual field testing at baseline and at least one follow-up round. The ophthalmic examinations included optic disc assessment and measurements of intraocular pressure (IOP), refractive error, diastolic blood pressure (DBP), and height and weight...
June 12, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28606272/-progression-of-the-pathogenesis-of-thyroid-associated-ophthalmopathy
#10
L Wang, J M Ma
Thyroid associated ophthalmopathy (TAO) is a common complication of Graves' disease (GD). The clinical manifestations are mainly swelling and retracted eyelid, protopsis and limited eye movements, and optic neuropathy can be seen in severe cases. The mechanism of TAO is not yet clear. A large number of studies have found that the disorders of autoimmunity play an important role in TAO, while genetic factors, oxidative stress, and environmental factors such as smoking participate in it. Therefore, we consult a large number of studies and expound the pathogenesis from the aspects of genetic susceptibility, immune mechanism, oxidative stress, and the effects of smoking to provide referrences for clinical associated studies...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28606262/-therapeutic-outcomes-and-influence-factors-of-maximal-orbital-decompression-in-the-treatment-of-severe-dysthyroid-optic-neuropathy
#11
Y Wang, Y Y Li, N Yang, R Ma, L H Xiao
Objective: To evaluate the effectiveness of maximal orbital decompression in treatment for severe dysthyroid optic neuropathy (DON) of thyroid associated ophthalmopathy (TAO) and predictive factors of this therapy. Methods: The group consisted of 21 patients (30 eyes) with DON. The diagnosis was based on the following criteria: Deterioration of best corrected visual acuity (VA≤0.1), enlargement of extraocular muscles and sign of apical crowding in CT imaging, loss of colour vision. EXCLUSION CRITERIA: VA of DON>0...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28606115/peripheral-neuropathy-in-a-diabetic-child-treated-with-linezolid-for-multidrug-resistant-tuberculosis-a-case-report-and-review-of-the-literature
#12
Aravind Swaminathan, Philipp du Cros, James A Seddon, Shamsiya Mirgayosieva, Rajabov Asladdin, Zulfiya Dusmatova
BACKGROUND: Extensively drug-resistant (XDR) tuberculosis (TB) and multidrug resistant (MDR)-TB with additional resistance to injectable agents or fluoroquinolones are challenging to treat due to lack of available, effective drugs. Linezolid is one of the few drugs that has shown promise in treating these conditions. Long-term linezolid use is associated with toxicities such as peripheral and optic neuropathies. Diabetes mellitus (DM), especially when uncontrolled, can also result in peripheral neuropathy...
June 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28605811/parapapillary-deep-layer-microvasculature-dropout-in-glaucoma-topographic-association-with-glaucomatous-damage
#13
Eun Ji Lee, Seung Hyen Lee, Jeong-Ah Kim, Tae-Woo Kim
Purpose: The purpose of this article was to compare the frequencies of the parapapillary deep-layer microvasculature dropout (MvD) detected by optical coherence tomography angiography in eyes with primary open-angle glaucoma (POAG) and healthy eyes and to determine the topographic correlation between the MvD and the glaucomatous retinal nerve fiber layer (RNFL) defect in POAG eyes. Methods: Microvasculature in the peripapillary deep-layer was evaluated in 150 POAG patients and 45 healthy controls using swept-source optical coherence tomography angiography to identify an MvD...
June 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28590394/the-outcome-of-endoscopic-optic-nerve-decompression-for-bilateral-traumatic-optic-neuropathy
#14
Daoyu Xie, Hailing Yu, Jianbao Ju, Li Zhang
OBJECTIVE: To investigate the outcomes of endoscopic optic nerve decompression (EOND) for bilateral traumatic optic neuropathy (TON). METHODS: A retrospective analysis was conducted in 5 patients with bilateral TON, between January 2003 and December 2013. All the patients underwent preoperative ophthalmological evaluation, flash visual-evoked potentials, computed tomography scan, and systemic corticosteroid therapy. All the patients required an EOND surgery, due to poor response to medical therapy, and the remainder one was only treated with corticosteroid due to operative contraindication...
June 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28586576/non-arteritic-anterior-ischemic-optic-neuropathy-does-anticoagulation-help
#15
Akhunzada Muhammad Aftab, Mustafa Iqbal, Awais Rauf, Asif Ali
BACKGROUND: Non Arteritic Anterior Ischemic Optic Neuropathy (NAION) is the most common acute optic neuropathy in patients over 50 years of age. This study was conducted to determine the beneficial effects of anticoagulation with Heparin and Warfarin in patients with NAION presenting within 4 weeks of onset of symptoms. METHODS: A prospective, interventional, pilot study was conducted in Eye- A unit of Khyber Teaching Hospital from July 2010 onwards on patients with NAION presenting within 4 weeks of onset of symptoms...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28585489/evaluation-of-the-radiation-dose-volume-effects-of-optic-nerves-and-chiasm-by-psychophysical-electrophysiologic-tests-and-optical-coherence-tomography-in-nasopharyngeal-carcinoma
#16
Ozlem Ozkaya Akagunduz, Suzan Guven Yilmaz, Deniz Yalman, Berna Yuce, Elif Demirkilinc Biler, Filiz Afrashi, Mustafa Esassolak
PURPOSE: To evaluate the radiation dose-volume effects of optic nerves and chiasm by visual psychophysical, electrophysiologic tests, and optical coherence tomography in patients with locally advanced nasopharyngeal carcinoma. MATERIALS AND METHODS: A series of visual tests including visual acuity, visual field, contrast sensitivity, visual evoked potential, and optical coherence tomography were administered to 20 patients with locally advanced (T3-T4) nasopharyngeal carcinoma who were treated with definitive chemoradiotherapy...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28582368/spontaneous-resolution-of-optic-neuropathy-in-sphenoid-wing-meningioma
#17
Sathyadeepak Ramesh, Robert Alan Goldberg, Daniel Benson Rootman
The authors describe herein a case of optic neuropathy in progesterone receptor positive sphenoid wing meningioma of the greater wing which demonstrated spontaneous recovery with conservative management.
June 2, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28579746/psychological-morbidity-in-leber-s-hereditary-optic-neuropathy-depends-on-phenotypic-social-economic-and-genetic-factors
#18
COMMENT
Josef Finsterer, Sinda Zarrouk-Mahjoub
No abstract text is available yet for this article.
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28570722/use-of-corneal-confocal-microscopy-to-detect-corneal-nerve-loss-and-increased-dendritic-cells-in-patients-with-multiple-sclerosis
#19
Gulfidan Bitirgen, Zehra Akpinar, Rayaz A Malik, Ahmet Ozkagnici
Importance: Multiple sclerosis (MS) is characterized by demyelination, axonal degeneration, and inflammation. Corneal confocal microscopy has been used to identify axonal degeneration in several peripheral neuropathies. Objective: To assess corneal subbasal nerve plexus morphologic features, corneal dendritic cell (DC) density, and peripapillary retinal nerve fiber layer (RNFL) thickness in patients with MS. Design, Setting, and Participants: This single-center, cross-sectional comparative study was conducted at a tertiary referral university hospital between May 27, 2016, and January 30, 2017...
June 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28553559/next-generation-perg-method-expanding-the-response-dynamic-range-and-capturing-response-adaptation
#20
Pedro Monsalve, Giacinto Triolo, Jonathon Toft-Nielsen, Jorge Bohorquez, Amanda D Henderson, Rafael Delgado, Edward Miskiel, Ozcan Ozdamar, William J Feuer, Vittorio Porciatti
PURPOSE: To compare a new method for steady-state pattern electroretinogram (PERGx) with a validated method (PERGLA) in normal controls and in patients with optic neuropathy. METHODS: PERGx and PERGLA were recorded in a mixed population (n = 33, 66 eyes) of younger controls (C1; n = 10, age 38 ± 8.3 years), older controls (C2; n = 11, 57.9 ± 8.09 years), patients with early manifest glaucoma (G; n = 7, 65.7 ±11.6 years), and patients with nonarteritic ischemic optic neuropathy (N; n = 5, mean age 59...
May 2017: Translational Vision Science & Technology
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