keyword
MENU ▼
Read by QxMD icon Read
search

Optic neuropathy

keyword
https://www.readbyqxmd.com/read/29663564/association-between-nasopharyngeal-carcinoma-and-risk-of-optic-neuropathy-a-population-based-cohort-study
#1
Chao-Yueh Fan, Yee-Min Jen, Yuan-Chih Su, Hsing-Lung Chao, Chun-Shu Lin, Wen-Yen Huang, Miao-Jung Lin, Chia-Hung Kao
BACKGROUND: The purpose of this study was to assess the predictive factors of optic neuropathy among patients with nasopharyngeal carcinoma (NPC). METHODS: The analysis included 16 297 patients with NPC and 65 187 controls. Each patient with NPC was randomly frequency-matched with 4 individuals without NPC by age, sex, and index year. Cox proportional hazard models were applied to measure the hazard ratios (HRs) and 95% confidence intervals (CIs) of optic neuropathy development associated with NPC...
April 16, 2018: Head & Neck
https://www.readbyqxmd.com/read/29659172/optic-disc-drusen-understanding-an-old-problem-from-a-new-perspective
#2
REVIEW
Steffen Hamann, Lasse Malmqvist, Fiona Costello
Optic disc drusen (ODD) are acellular deposits located in the optic nerve head of up to 2.4% of the population. They may develop as by-products of impaired axonal metabolism in genetically predisposed individuals, in whom a narrow scleral canal is hypothesized to play a role. Although ODD are often considered as benign innocent bystanders, recognized as part of a routine ophthalmological examination, the vast majority of patients with ODD have visual field defects. Optic disc drusen (ODD)-associated complications with severe visual loss, most often due to anterior ischaemic optic neuropathy, are also known to occur...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29657892/inversion-recovery-sequences-improve-delineation-of-optic-pathways-in-the-proximity-of-suprasellar-lesions
#3
Herwin Speckter, José Bido, Giancarlo Hernandez, Diones Rivera, Luis Suazo, Santiago Valenzuela, Rafael Fermin, Jairo Oviedo, Bernd Foerster, Cesar Gonzalez, Peter Stoeter
Introduction: In Gamma Knife Radiosurgery (GKRS) of suprasellar lesions, the exact localization of the visual pathways is important to avoid radiation induced optic neuropathy (RION). Reliable identification of the optic nerve, chiasm and tracts can be challenging using routine magnetic resonance imaging, especially in patients with lesions compressing the optic structures or in patients who had prior operation of suprasellar tumors. This study investigates the application of inversion recovery sequences (Fast gray and white matter acquisition T1 inversion recovery, FGATIR) to improve identification of the optic pathway...
2018: Journal of Radiosurgery and SBRT
https://www.readbyqxmd.com/read/29652203/clinical-features-of-toxocara-seropositive-optic-neuritis-in-korea
#4
Hyeshin Jeon, Young Hwan Jeong, Hee-Young Choi, Ji Eun Lee, Iksoo Byon, Sung Who Park
PURPOSE: This study was undertaken to analyze the characteristics of optic neuritis in Korean patients seropositive for Toxocara. METHODS: We retrospectively reviewed data from patients diagnosed with optic neuritis and followed up for at least one month between 2012 and 2016. Patients were grouped according to Toxocara serological testing outcomes (positive or negative) and clinical characteristics were compared. RESULTS: The seropositive and seronegative groups comprised 13 and 12 patients, respectively...
April 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29649995/the-prevalence-and-systemic-risk-factors-of-diabetic-macular-edema-a-cross-sectional-study-from-turkey
#5
Durgul Acan, Mehmet Calan, Duygu Er, Tugba Arkan, Nilufer Kocak, Firat Bayraktar, Suleyman Kaynak
BACKGROUND: The aim of this study was to evaluate the prevalence of diabetic macular edema (DME) utilizing optical coherence tomography (OCT), and to clarify the effects of the systemic findings and risk factors on the development of DME. METHODS: This cross-sectional study was conducted in the departments of ophthalmology and endocrinology at the Dokuz Eylul University School of Medicine in Izmir, Turkey. The demographics, type and duration of diabetes mellitus, treatment modality, smoking and alcohol consumption habits, as well as the systemic blood pressure, renal functional tests, hemoglobulin A1c level, serum lipid profile, and 24-h urine albumin level were noted and statistically analyzed...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29649796/visual-field-variability-after-gene-therapy-for-leber-s-hereditary-optic-neuropathy
#6
Jia-Jia Yuan, Yong Zhang, Li-Ling Wang, Ming-Shi Cheng, Si-Qi Ma, Qin Gao, Bin Li
PURPOSE: To assess changes in visual field (VF) values after gene therapy for Leber's hereditary optic neuropathy (LHON). METHODS: VF recovery, VF indices, and mean deviation in injected and uninjected eyes, before and after gene therapy, were examined in 2 groups of patients according to disease duration (≤2 years and > 2 years). Nine patients with LHON were treated by monocular intravitreal injection of AAV2-ND4. Finally, 7 patients were considered for subsequent comparisons; the first and second eyes were treated separately...
April 12, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29627627/postoperative-posterior-ischemic-optic-neuropathy-a-left-far-lateral-craniectomy-for-resection-of-craniocervical-meningioma
#7
Ilyas M Eli, Robert B Kim, Craig Kilburg, Travis J Pecha, William T Couldwell, Sarah T Menacho
BACKGROUND: Postoperative posterior ischemic optic neuropathy (PION) is a rare cause of postoperative vision loss, most often seen when surgical patients are placed in the prone position for a prolonged period of time. The authors report a case of bilateral PION after a far-lateral craniectomy in the lateral position. CASE DESCRIPTION: A 36-year-old man with a history of right extremity numbness, weakness, and muscle atrophy was discovered to have a craniocervical meningioma...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29625838/suppression-of-melatonin-secretion-in-totally-visually-blind-people-by-ocular-exposure-to-white-light-clinical-characteristics
#8
Joseph T Hull, Charles A Czeisler, Steven W Lockley
PURPOSE: Although most totally visually blind individuals exhibit nonentrained circadian rhythms due to an inability of light to entrain the circadian pacemaker, a small proportion retain photic circadian entrainment, melatonin suppression, and other nonimage-forming responses to light. It is thought that these responses to light persist because of the survival of melanospin-containing intrinsically photosensitive retinal ganglion cells (ipRGCs), which project primarily to the circadian pacemaker and are functionally distinct from the rod and cone photoreceptors that mediate vision...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29623524/could-buerger-s-disease-cause-nonarteritic-anterior-ischemic-optic-neuropathy-a-rare-case-report
#9
Anil Korkmaz, Omer Karti, Dilek Top Karti, Bora Yüksel, Mehmet Ozgur Zengin, Tuncay Kusbeci
We present an interesting case with nonarteritic anterior ischemic optic neuropathy (NAION) accompanied by Buerger's disease. A 43-year-old man was referred to our neuro-ophthalmology clinic with a complaint of visual deterioration in the left eye that started 5 days ago. He suffered from Buerger's disease, and he had acute pain in the right lower limb below the knee. His best corrected visual acuity was 10/10 in the right eye and 2/10 in the left eye by Snellen chart. There was a relative afferent pupil defect in the left eye...
April 5, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29615737/longterm-reversal-of-severe-visual-loss-by-mitochondrial-gene-transfer-in-a-mouse-model-of-leber-hereditary-optic-neuropathy
#10
Hong Yu, Vittorio Porciatti, Alfred Lewin, William Hauswirth, John Guy
In many human disorders mitochondrial dysfunction is central to degeneration of retinal ganglion cells. As these cells do not regenerate, vision is irreversibly lost. Here we show reversal of visual dysfunction by a mitochondrially targeted adeno associated virus in transgenic mice harboring a G11778A mutation in the ND4 subunit of complex I persists longterm and it is associated with reduced loss of RGCs and their axons, improved oxidative phosphorylation, persistence of transferred ND4 DNA and transcription of ND4 mRNA...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29613917/does-dolichoectasia-of-the-carotid-artery-cause-optic-neuropathy
#11
Valerie I Elmalem, Valerie A Purvin
No abstract text is available yet for this article.
April 2, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29611471/peroxisome-proliferated-activated-receptors-ppars-opportunities-and-challenges-for-ocular-therapy
#12
Prachi Khatol, Shivani Saraf, Ankit Jain
Peroxisome proliferator-activated receptors (PPARs) are nuclear transcription factors. They exist in three isoforms (PPAR-α, PPAR-β/δ, and PPAR-Υ) in humans, but mainly PPAR-Υ, and they are expressed in retinal epithelial pigment. PPARs are involved in mediating numerous pathological implications in eye such as diabetic retinopathy (DR), choroidal neovascularization (CNV), glaucoma, diabetic macular edema, and other retinal diseases. Peroxisome proliferator-activated receptors are key players in various biological pathways like lipid degeneration, immune regulation, and reactive oxygen species regulation, regulation of vascular endothelial growth factor, matrixmetalloproteinase-9, and docosahexaenoic acid pathway...
2018: Critical Reviews in Therapeutic Drug Carrier Systems
https://www.readbyqxmd.com/read/29608906/excess-homocysteine-upregulates-the-nrf2-antioxidant-pathway-in-retinal-m%C3%A3-ller-glial-cells
#13
Soumya Navneet, Xuezhi Cui, Jing Zhao, Jing Wang, Navneet Ammal Kaidery, Bobby Thomas, Kathryn E Bollinger, Yisang Yoon, Sylvia B Smith
This study evaluated the effects of elevated homocysteine (Hcy) on the oxidative stress response in retinal Müller glial cells. Elevated Hcy has been implicated in retinal diseases including glaucoma and optic neuropathy, which are characterized by retinal ganglion cell (RGC) loss. To understand the mechanisms of Hcy-induced RGC loss, in vitro and in vivo models have been utilized. In vitro isolated RGCs are quite sensitive to elevated Hcy levels, while in vivo murine models of hyperhomocysteinemia (HHcy) demonstrate a more modest RGC loss (∼20%) over a period of many months...
March 30, 2018: Experimental Eye Research
https://www.readbyqxmd.com/read/29600190/-toxocara-optic-neuropathy-clinical-features-and-ocular-findings
#14
Kwang-Dong Choi, Jae-Hwan Choi, Seo-Young Choi, Jae Ho Jung
We evaluated thirteen eyes of twelve patients diagnosed clinically and serologically with Toxocara optic neuropathy. Eleven patients had unilateral involvement and one patient had bilateral optic neuropathy. Eight patients (66.7%) had a possible infection source to Toxocara. Six patients (50%) had painless acute optic neuropathy. Ten eyes had asymmetric, sectorial optic disc edema with peripapillary infiltration and three eyes had diffuse optic disc edema. Eosinophilia was noted in five patients (41.7%) and optic nerve enhancement was observed in eight of eleven eyes (72...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29597010/boston-keratoprosthesis-type-1-for-limbal-stem-cell-deficiency-after-severe-chemical-corneal-injury-a-systematic-review
#15
REVIEW
Swapna S Shanbhag, Hajirah N Saeed, Eleftherios I Paschalis, James Chodosh
PURPOSE: To systematically review the published literature on outcomes of Boston keratoprosthesis type 1 for the treatment of limbal stem cell deficiency secondary to severe chemical corneal injury. METHODS: Literature searches were conducted in MEDLINE (Ovid), Embase, Web of Science, and the Cochrane Central Register. The main outcome measures assessed were the proportion of eyes with best-corrected visual acuity (BCVA) ≥ 20/200 and the proportion retaining their original keratoprosthesis, both at the last recorded visit...
March 26, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29595636/evidence-based-practice-guideline-of-chinese-herbal-medicine-for-primary-open-angle-glaucoma-qingfeng-neizhang
#16
Yingxin Yang, Qiu-Yan Ma, Yue Yang, Yu-Peng He, Chao-Ting Ma, Qiang Li, Ming Jin, Wei Chen
BACKGROUND: Primary open angle glaucoma (POAG) is a chronic, progressive optic neuropathy. The aim was to develop an evidence-based clinical practice guideline of Chinese herbal medicine (CHM) for POAG with focus on Chinese medicine pattern differentiation and treatment as well as approved herbal proprietary medicine. METHODS: The guideline development group involved in various pieces of expertise in contents and methods. Authors searched electronic databases include CNKI, VIP, Sino-Med, Wanfang data, PubMed, the Cochrane Library, EMBASE, as well as checked China State Food and Drug Administration (SFDA) from the inception of these databases to June 30, 2015...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29594838/the-relation-between-retrobulbar-blood-flow-and-posterior-ocular-changes-measured-using-spectral-domain-optical-coherence-tomography-in-patients-with-obstructive-sleep-apnea-syndrome
#17
Hüseyin Fındık, Metin Çeliker, Mehmet Gökhan Aslan, Fatma Beyazal Çeliker, Mehmet Fatih İnecikli, Engin Dursun, Murat Okutucu, Ünal Şahin
PURPOSE: To investigate the effect of posterior ocular hemodynamics on the retinal nerve fiber layer (RNFL), choroid thickness (CT) and central macular thickness (CMT) in patients with obstructive sleep apnea syndrome (OSAS) and to reveal the association with glaucomatous optic neuropathy. METHODS: The research was planned as a prospective, randomized study. The ophthalmic, retinal and posterior ciliary artery pulsatile index (PI) and resistive index (RI) were measured by colored Doppler sonography...
March 29, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29594060/prevalence-of-radiological-signs-of-dysthyroid-optic-neuropathy-in-magnetic-resonance-imaging-in-patients-with-active-moderate-to-severe-and-very-severe-graves-orbitopathy
#18
Beata Rutkowska-Hinc, Edyta Maj, Anna Jabłońska, Justyna Milczarek-Banach, Tomasz Bednarczuk, Piotr Miśkiewicz
Background: Differentiating between dysthyroid optic neuropathy (DON), which requires urgent therapy to prevent blindness, and moderate-to-severe Graves orbitopathy (GO) remains challenging. There is no pathognomonic feature of DON in either ophthalmological or radiological examinations. Objectives: Our aim was to investigate the prevalence of radiological signs of DON in magnetic resonance imaging (MRI) in patients with moderate-to-severe and very severe GO. Methods: Two researchers reassessed MRI scans of 23 consecutive patients (46 eyes) with active, moderate-to-severe GO and 14 patients (23 eyes) with very severe GO...
March 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29579248/leber-s-hereditary-optic-neuropathy-lhon-associated-nd5-12338t-c-mutation-altered-the-assembly-and-function-of-complex-i-apoptosis-and-mitophagy
#19
Juanjuan Zhang, Yanchun Ji, Yuanyuan Lu, Runing Fu, Man Xu, Xiaoling Liu, Min-Xin Guan
Mutations in mitochondrial DNA (mtDNA) have been associated with Leber's hereditary optic neuropathy (LHON) and their pathophysiology remains poorly understood. In this study, we demonstrated that a missense mutation (m.12338T>C, p.1M>T) in the ND5 gene contributed to the pathogenesis of LHON. The m.12338T>C mutation affected the first methionine (Met1) with a threonine and shortened two amino acids of ND5. We therefore hypothesized that the mutated ND5 perturbed the structure and function of complex I...
March 22, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29576898/orbital-apex-syndrome-secondary-to-herpes-zoster-ophthalmicus
#20
Gamze Kocaoğlu, Canan Aslı Utine, Aylin Yaman, Süleyman Men
Orbital apex syndrome is a rare complication of herpes zoster ophthalmicus. A patient being followed in our clinic for herpes zoster ophthalmicus developed orbital apex syndrome in the second week of treatment. Clinical diagnosis was supported by magnetic resonance imaging. Treatment with systemic steroid and antiviral therapy resulted in total regression of ophthalmoplegia at 2 months. However, optic neuropathy-induced vision loss was permanent. This case report examines orbital apex syndrome secondary to herpes zoster ophthalmicus, which has rarely been documented in the ophthalmic literature...
February 2018: Turkish Journal of Ophthalmology
keyword
keyword
24216
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"