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https://www.readbyqxmd.com/read/28107026/impact-of-mobile-intensive-care-unit-use-on-total-ischemic-time-and-clinical-outcomes-in-st-elevation-myocardial-infarction-patients-real-world-data-from-the-acute-coronary-syndrome-israeli-survey
#1
Edward Koifman, Roy Beigel, Zaza Iakobishvili, Nir Shlomo, Yitschak Biton, Avi Sabbag, Elad Asher, Shaul Atar, Shmuel Gottlieb, Ronny Alcalai, Doron Zahger, Amit Segev, Ilan Goldenberg, Rafael Strugo, Shlomi Matetzky
BACKGROUND: Ischemic time has prognostic importance in ST-elevation myocardial infarction patients. Mobile intensive care unit use can reduce components of total ischemic time by appropriate triage of ST-elevation myocardial infarction patients. METHODS: Data from the Acute Coronary Survey in Israel registry 2000-2010 were analyzed to evaluate factors associated with mobile intensive care unit use and its impact on total ischemic time and patient outcomes. RESULTS: The study comprised 5474 ST-elevation myocardial infarction patients enrolled in the Acute Coronary Survey in Israel registry, of whom 46% ( n=2538) arrived via mobile intensive care units...
January 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28097381/rotating-night-shift-work-sleep-and-colorectal-adenoma-in-women
#2
Elizabeth E Devore, Jennifer Massa, Kyriaki Papantoniou, Eva S Schernhammer, Kana Wu, Xuehong Zhang, Walter C Willett, Charles S Fuchs, Andrew T Chan, Shuji Ogino, Edward Giovannucci, Esther K Wei
PURPOSE: This study aims to investigate the associations of rotating night shift work history and sleep duration with risk of colorectal adenoma. METHODS: We evaluated 56,275 cancer-free participants of the Nurses' Health Study II, who had their first colonoscopy or sigmoidoscopy between 1991 and 2011; rotating night shift work and sleep duration were reported by mailed questionnaire. Multivariable-adjusted logistic regression was used to estimate relative risks (RR) of colorectal adenoma, with 95% confidence intervals (CI), across categories of rotating night shift work history (none, 1-4, 5-9, and ≥10 years) and sleep duration (≤5, 6, 7, 8, and ≥9 h/day)...
January 17, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28076288/transfer-rnas-with-novel-cloverleaf-structures
#3
Takahito Mukai, Oscar Vargas-Rodriguez, Markus Englert, H James Tripp, Natalia N Ivanova, Edward M Rubin, Nikos C Kyrpides, Dieter Söll
We report the identification of novel tRNA species with 12-base pair amino-acid acceptor branches composed of longer acceptor stem and shorter T-stem. While canonical tRNAs have a 7/5 configuration of the branch, the novel tRNAs have either 8/4 or 9/3 structure. They were found during the search for selenocysteine tRNAs in terabytes of genome, metagenome and metatranscriptome sequences. Certain bacteria and their phages employ the 8/4 structure for serine and histidine tRNAs, while minor cysteine and selenocysteine tRNA species may have a modified 8/4 structure with one bulge nucleotide...
October 5, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/28073298/extraperitoneal-vs-transperitoneal-robot-assisted-radical-prostatectomy-in-the-setting-of-prior-abdominal-or-pelvic-surgery
#4
David Horovitz, Changyong Feng, Edward M Messing, Jean Volny Joseph
INTRODUCTION: During Robotic-Assisted Radical Prostatectomy (RARP), the prostate may be approached extraperiteoneally (eRARP) or transperitoneally (tRARP). The former avoids the abdominal cavity which might be of benefit in patients who have had prior abdominal or pelvic surgery (PAPS). Our objective was to compare the outcomes of patients with PAPS undergoing either technique. METHODS: A retrospective review of patients treated with RARP from July 1, 2003-Dec. 31, 2014 with a minimum follow-up of 3 months was undertaken...
January 10, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28067512/substituent-and-solvent-effects-on-the-stability-of-n-heterocyclic-carbene-complexes-with-co2
#5
Derek M Denning, Daniel Edward Falvey
Carbon dioxide forms covalent complexes with N-heterocyclic carbenes. These complexes are of interest in catalysis as well as for their potential use in various carbon capture and storage strategies. A previous report showed that the stability one such complex, N,N-dimethylimidazolium-2-carboxylate, was remarkably sensitive to solvent polarity. Polar environments lead to a kinetically stronger, shorter, and more polar bond between the carbene and CO2. The current study shows that this solvent effect is general across a wide range of NHC complexes with CO2...
January 9, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28061371/low-level-arsenic-exposure-via-drinking-water-consumption-and-female-fecundity-a-preliminary-investigation
#6
Michele L Susko, Michael S Bloom, Iulia A Neamtiu, Allison A Appleton, Simona Surdu, Cristian Pop, Edward F Fitzgerald, Doru Anastasiu, Eugen S Gurzau
High level arsenic exposure is associated with reproductive toxicity in experimental and observational studies; however, few data exist to assess risks at low levels. Even less data are available to evaluate the impact of low level arsenic exposure on human fecundity. Our aim in this pilot study was a preliminary evaluation of associations between low level drinking water arsenic contamination and female fecundity. This retrospective study was conducted among women previously recruited to a hospital-based case-control study of spontaneous pregnancy loss in Timiṣ County, Romania...
January 3, 2017: Environmental Research
https://www.readbyqxmd.com/read/28055959/preoperative-low-tri-iodothyronine-concentration-is-associated-with-worse-health-status-and-shorter-five-year-survival-of-primary-brain-tumor-patients
#7
Adomas Bunevicius, Vytenis Pranas Deltuva, Sarunas Tamasauskas, Timothy Smith, Edward R Laws, Robertas Bunevicius, Giorgio Iervasi, Arimantas Tamasauskas
BACKGROUND: Low tri-iodothyronine syndrome is associated with worse prognosis of severely ill patients. We investigated the association of thyroid hormone levels with discharge outcomes and 5-year mortality in primary brain tumor patients. METHODS: From January, 2010 until September, 2011, 230 patients (70% women) before brain tumor surgery were evaluated for cognitive (Mini mental State Examination; MMSE) and functional (Barthel index; BI) status, and thyroid function profile...
December 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/28054734/compassionate-use-experience-with-high-titer-respiratory-syncytical-virus-rsv-immunoglobulin-in-rsv-infected-immunocompromised-persons
#8
Ann R Falsey, Christine Koval, John P DeVincenzo, Edward E Walsh
BACKGROUND: Respiratory syncytial virus (RSV) may cause fatal lower respiratory tract infection (LRTI) in immunocompromised patients. Ribavirin with or without standard intravenous immunoglobulin (IVIG) is frequently given although efficacy is debated. Infusion of IVIG with high levels of neutralizing antibody against RSV may offer benefit in these patients. METHODS: RI-001 contains standardized levels of high-titer anti-RSV neutralizing antibody and was provided for compassionate use to 15 patients with RSV LRTI who either failed conventional therapy or had significant risk of progression...
January 5, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28041827/application-of-the-mascc-and-cisne-risk-stratification-scores-to-identify-low-risk-febrile-neutropenic-patients-in-the-emergency-department
#9
Christopher J Coyne, Vivian Le, Jesse J Brennan, Edward M Castillo, Rebecca A Shatsky, Karen Ferran, Stephanie Brodine, Gary M Vilke
STUDY OBJECTIVE: Although validated risk-stratification tools have been used to send low-risk febrile neutropenic patients home from clinic and inpatient settings, there is a dearth of research evaluating these scores in the emergency department (ED). We compare the predictive accuracy of the Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for patients with chemotherapy-induced febrile neutropenia and presenting to the ED...
December 29, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27995128/intravenous-topiramate-pharmacokinetics-in-dogs-with-naturally-occurring-epilepsy
#10
Irene Vuu, Lisa D Coles, Patricia Maglalang, Ilo E Leppik, Greg Worrell, Daniel Crepeau, Usha Mishra, James C Cloyd, Edward E Patterson
RATIONALE: Barriers to developing treatments for human status epilepticus include the inadequacy of experimental animal models. In contrast, naturally occurring canine epilepsy is similar to the human condition and can serve as a platform to translate research from rodents to humans. The objectives of this study were to characterize the pharmacokinetics of an intravenous (IV) dose of topiramate (TPM) in dogs with epilepsy and evaluate its effect on intracranial electroencephalographic (iEEG) features...
2016: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/27989080/immediate-outcomes-of-aortic-valve-replacement-with-sutureless-versus-stentless-bioprosthesis
#11
Ali Ihsan Parlar, Muhammet Onur Hanedan, Ilker Mataraci, Mehmet Ali Yuruk, Ufuk Sayar, Ali Kemal Arslan, Tanil Ozer
BACKGROUND: Aortic valve replacement (AVR) with a sutureless valve is an innovative therapy in high-risk elderly patients. The study aim was to compare the early results of AVR using sutureless aortic valves or stentless aortic bioprostheses. METHODS: A retrospective analysis was conducted of 55 patients who underwent AVR with either a sutureless valve (Perceval S; n = 24 or Edwards Intuity; n = 9) or a stentless valve (Sorin Freedom SOLO™; n = 22). RESULTS: Baseline patient characteristics were similar in both groups, except for NYHA class...
January 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27988777/morphological-differences-between-i-stenocionops-i-i-furcatus-i-olivier-1791-and-i-s-coelatus-i-a-milne-edwards-1878-crustacea-decapoda-brachyura-majoidea
#12
Jessica Colavite, William Santana, Marcos Tavares
Stenocionops furcatus (Olivier, 1791) and S. coelatus (A. Milne-Edwards, 1878) have been treated either as subspecies or as species in their own right, but never as each other's synonyms. Compared to S. coelatus, S. furcatus has been regarded as having smoother dorsal surface carapace, shorter rostral spines, straighter and less divergent rostrum. and smaller interorbital width. These morphological differences between the two species, however, can be attributed to changes over ontogeny and, therefore, cannot be used as distinguishing characters...
November 7, 2016: Zootaxa
https://www.readbyqxmd.com/read/27979356/neuropathological-and-genetic-correlates-of-survival-and-dementia-onset-in-synucleinopathies-a-retrospective-analysis
#13
David J Irwin, Murray Grossman, Daniel Weintraub, Howard I Hurtig, John E Duda, Sharon X Xie, Edward B Lee, Vivianna M Van Deerlin, Oscar L Lopez, Julia K Kofler, Peter T Nelson, Gregory A Jicha, Randy Woltjer, Joseph F Quinn, Jeffery Kaye, James B Leverenz, Debby Tsuang, Katelan Longfellow, Dora Yearout, Walter Kukull, C Dirk Keene, Thomas J Montine, Cyrus P Zabetian, John Q Trojanowski
BACKGROUND: Great heterogeneity exists in survival and the interval between onset of motor symptoms and dementia symptoms across synucleinopathies. We aimed to identify genetic and pathological markers that have the strongest association with these features of clinical heterogeneity in synucleinopathies. METHODS: In this retrospective study, we examined symptom onset, and genetic and neuropathological data from a cohort of patients with Lewy body disorders with autopsy-confirmed α synucleinopathy (as of Oct 1, 2015) who were previously included in other studies from five academic institutions in five cities in the USA...
January 2017: Lancet Neurology
https://www.readbyqxmd.com/read/27974555/vp24-karyopherin-alpha-binding-affinities-differ-between-ebolavirus-species-influencing-interferon-inhibition-and-vp24-stability
#14
Toni M Schwarz, Megan R Edwards, Audrey Diederichs, Joshua B Alinger, Daisy W Leung, Gaya K Amarasinghe, Christopher F Basler
: Zaire ebolavirus (EBOV), Bundibugyo ebolavirus (BDBV) and Reston ebolavirus (RESTV) belong to the same genus, Ebolavirus, but exhibit different virulence properties. VP24 protein, a structural protein present in all family members, blocks interferon (IFN) signaling and likely contributes to virulence. Inhibition of IFN signaling by EBOV VP24 (eVP24) involves its interaction with the NPI-1 subfamily of karyopherin alpha (KPNA) nuclear transporters. Here, we evaluated eVP24, BDBV VP24 (bVP24) and RESTV VP24 (rVP24) interactions with three NPI-1 subfamily KPNAs (KPNA1, KPNA5 and KPNA6)...
December 14, 2016: Journal of Virology
https://www.readbyqxmd.com/read/27932492/novel-regulatory-roles-of-mff-and-drp1-in-e3-ubiquitin-ligase-march5-dependent-degradation-of-mid49-and-mcl1-and-control-of-mitochondrial-dynamics
#15
Edward Cherok, Shan Xu, Sunan Li, Shweta Das, W Alex Meltzer, Michal Zalzman, Chunxin Wang, Mariusz Karbowski
MARCH5, an OMM-associated E3 ubiquitin ligase, controls mitochondrial function. Despite its importance, the mechanism and factors controlling MARCH5 activity are largely unknown. Here we report that the MARCH5 C-terminal domain plays a critical role in degradation of MARCH5 substrates, likely by facilitating release of ubiquitinated proteins from the OMM. We also found that the mitochondrial fission proteins Drp1 and Mff negatively regulate MARCH5's activity toward MiD49 and Mcl1. Knockouts of either Drp1 or Mff led to reduced expression, shorter half-lives, and increased ubiquitination of MiD49 and Mcl1...
December 8, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27891654/the-relationship-between-oestrogen-receptor-alpha-phosphorylation-and-the-tumour-microenvironment-in-patients-with-primary-operable-ductal-breast-cancer
#16
Kelvin K W Cheng, Ashley Dickson, Fadia J A Gujam, Donald C McMillan, Joanne Edwards
AIMS: Although the role of phosphorylation of oestrogen receptor (ER) at serines 118 (p-S118) and 167 (p-S167) have been studied, the relationship between p-S118, p-S167 and the tumour microenvironment in ER-positive primary operable ductal breast cancers have not been investigated. The aims of this study are to investigate (1) the relationship between p-S118/p-S167 and the tumour microenvironment and (2) the effect of p-S118/167 on survival and recurrence in ER-positive primary operable ductal breast cancers...
November 28, 2016: Histopathology
https://www.readbyqxmd.com/read/27797938/leucocyte-telomere-length-genetic-variants-at-the-tert-gene-region-and-risk-of-pancreatic-cancer
#17
Ying Bao, Jennifer Prescott, Chen Yuan, Mingfeng Zhang, Peter Kraft, Ana Babic, Vicente Morales-Oyarvide, Zhi Rong Qian, Julie E Buring, Barbara B Cochrane, J Michael Gaziano, Edward L Giovannucci, JoAnn E Manson, Kimmie Ng, Shuji Ogino, Thomas E Rohan, Howard D Sesso, Meir J Stampfer, Charles S Fuchs, Immaculata De Vivo, Laufey T Amundadottir, Brian M Wolpin
OBJECTIVE: Telomere shortening occurs as an early event in pancreatic tumorigenesis, and genetic variants at the telomerase reverse transcriptase (TERT) gene region have been associated with pancreatic cancer risk. However, it is unknown whether prediagnostic leucocyte telomere length is associated with subsequent risk of pancreatic cancer. DESIGN: We measured prediagnostic leucocyte telomere length in 386 pancreatic cancer cases and 896 matched controls from five prospective US cohorts...
October 21, 2016: Gut
https://www.readbyqxmd.com/read/27788942/outcomes-of-a-less-invasive-approach-for-proximal-aortic-operations
#18
Melissa M Levack, Muhammad Aftab, Eric E Roselli, Douglas R Johnston, Edward G Soltesz, A Marc Gillinov, Gösta B Pettersson, Brian Griffin, Richard Grimm, Donald F Hammer, Adil H Al Kindi, Turki B Albacker, Edgardo Sepulveda, Lucy Thuita, Eugene H Blackstone, Joseph F Sabik, Lars G Svensson
BACKGROUND: Less-invasive techniques have previously been described for mitral and aortic valve operations; however, few studies have examined their benefit for aortic root and ascending aorta reconstruction. Using propensity matching, we compared outcomes of patients undergoing proximal aortic operations through a J incision compared with full sternotomy. METHODS: From January 1995 to January 2014, 8,533 patients underwent proximal aortic operations at Cleveland Clinic...
October 24, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27780536/placental-disease-and-abnormal-umbilical-artery-doppler-waveforms-in-trisomy-21-pregnancy-a-case-control-study
#19
Edward Corry, Fionnuala Mone, Ricardo Segurado, Paul Downey, Peter McParland, Fionnuala M McAuliffe, Eoghan E Mooney
INTRODUCTION: The objectives of this study were firstly to determine the proportion of placental pathology in fetuses affected by trisomy 21 (T21) using current pathological descriptive terminology and secondly to examine if a correlation existed between the finding of an abnormal umbilical artery Doppler (UAD) waveform, the presence of T21 and defined placental pathological categories. METHODS: This case-control study assessed singleton fetuses with karyotypically confirmed trisomy 21 where placental histopathology had been conducted from 2003 to 2015 inclusive, within a university tertiary obstetric centre...
November 2016: Placenta
https://www.readbyqxmd.com/read/27773453/patient-factors-associated-with-lung-transplant-referral-and-waitlist-for-patients-with-cystic-fibrosis-and-pulmonary-fibrosis
#20
Yuan Liu, Monica Vela, Tanya Rudakevych, Christopher Wigfield, Edward Garrity, Milda R Saunders
BACKGROUND: Since 2005, the Lung Allocation Score (LAS) has prioritized patient benefit and post-transplant survival, reducing waitlist to transplant time to <200 days and decreasing mortality on the waitlist. A current challenge is the wait for the waitlist-the time between the patient's transplant-eligible diagnosis and waitlist registration. METHODS: We investigated whether sociodemographic (age, sex, race, insurance, marital status, median household income) and clinical (forced expiratory volume in 1 second [FEV1] percent of predicted, body mass index, depression/anxiety, alcohol/substance misuse, absolute/relative contraindications) factors influenced referral and waitlist registration...
August 21, 2016: Journal of Heart and Lung Transplantation
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