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https://www.readbyqxmd.com/read/29782613/on-the-optimization-of-low-cost-fdm-3d-printers-for-accurate-replication-of-patient-specific-abdominal-aortic-aneurysm-geometry
#1
Michael Chung, Norbert Radacsi, Colin Robert, Edward D McCarthy, Anthony Callanan, Noel Conlisk, Peter R Hoskins, Vasileios Koutsos
Background: There is a potential for direct model manufacturing of abdominal aortic aneurysm (AAA) using 3D printing technique for generating flexible semi-transparent prototypes. A patient-specific AAA model was manufactured using fused deposition modelling (FDM) 3D printing technology. A flexible, semi-transparent thermoplastic polyurethane (TPU), called Cheetah Water (produced by Ninjatek, USA), was used as the flexible, transparent material for model manufacture with a hydrophilic support structure 3D printed with polyvinyl alcohol (PVA)...
2018: 3D Print Med
https://www.readbyqxmd.com/read/29781289/a-randomised-trial-comparing-spatio-temporal-gait-parameters-after-total-hip-arthroplasty-between-the-direct-anterior-and-direct-lateral-surgical-approaches
#2
Bryn O Zomar, Dianne Bryant, Susan Hunter, James L Howard, Edward M Vasarhelyi, Brent A Lanting
INTRODUCTION: Total hip arthroplasty (THA) is a successful procedure for relieving symptoms of severe osteoarthritis. Surgical approach is a key factor in early recovery and although controversial, little has been written about the direct anterior (DA) approach using objective early measures. METHODS: 78 participants were prospectively enrolled to undergo a THA through either a DA or direct lateral (DL) surgical approach. Outcome measures were collected preoperatively and at discharge from the hospital, and 2-, 6- and 12-weeks...
May 1, 2018: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29778443/combined-effects-of-hypoxia-or-elevated-temperature-and-deepwater-horizon-crude-oil-exposure-on-juvenile-mahi-mahi-swimming-performance
#3
Edward M Mager, Christina Pasparakis, John D Stieglitz, Ronald Hoenig, Jeffrey M Morris, Daniel D Benetti, Martin Grosell
This study examined potential interactive effects of co-exposure to Deepwater Horizon (DWH) crude oil (∼30 μg L-1 ΣPAHs) for 24 h and either hypoxia (2.5 mg O2 L-1 ; 40% O2 saturation) or elevated temperature (30 °C) on the swimming performance of juvenile mahi-mahi (Coryphaena hippurus). Additionally, effects of shorter duration exposures to equal or higher doses of oil alone either prior to swimming or during the actual swim trial itself were examined. Only exposure to hypoxia alone or combined with crude oil elicited significant decreases in critical swimming speed (Ucrit ) and to a similar extent (∼20%)...
May 5, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29773717/stk11-lkb1-mutations-and-pd-1-inhibitor-resistance-in-kras-mutant-lung-adenocarcinoma
#4
Ferdinandos Skoulidis, Michael E Goldberg, Danielle M Greenawalt, Matthew D Hellmann, Mark M Awad, Justin F Gainor, Alexa B Schrock, Ryan J Hartmaier, Sally E Trabucco, Laurie Gay, Siraj M Ali, Julia A Elvin, Gaurav Singal, Jeffrey S Ross, David Fabrizio, Peter M Szabo, Han Chang, Ariella Sasson, Sujaya Srinivasan, Stefan Kirov, Joseph Szustakowski, Patrik Vitazka, Robin Edwards, Jose A Bufill, Neelesh Sharma, Sai-Hong I Ou, Nir Peled, David R Spigel, Hira Rizvi, Elizabeth Jimenez Aguilar, Brett W Carter, Jeremy Erasmus, Darragh F Halpenny, Andrew J Plodkowski, Niamh M Long, Mizuki Nishino, Warren L Denning, Ana Galan-Cobo, Haifa Hamdi, Taghreed Hirz, Pan Tong, Jing Wang, Jaime Rodriguez-Canales, Pamela A Villalobos, Edwin R Parra, Neda Kalhor, Lynette M Sholl, Jennifer L Sauter, Achim A Jungbluth, Mari Mino-Kenudson, Roxana Azimi, Yasir Y Elamin, Jianjun Zhang, Giulia C Leonardi, Fei Jiang, Kwok-Kin Wong, J Jack Lee, Vassiliki A Papadimitrakopoulou, Ignacio I Wistuba, Vincent A Miller, Garrett M Frampton, Jedd D Wolchok, Alice T Shaw, Pasi A Jänne, Philip J Stephens, Charles M Rudin, William J Geese, Lee A Albacker, John V Heymach
KRAS is the most common oncogenic driver in lung adenocarcinoma (LUAC). We previously reported that STK11/LKB1 (KL) or TP53 (KP) co-mutations define distinct subgroups of KRAS-mutant LUAC. Here, we examine the efficacy of PD-1 inhibitors in these subgroups. Objective response rates to PD-1 blockade differed significantly among KL (7.4%), KP (35.7%), and K-only (28.6%) subgroups (P<0.001) in the SU2C cohort (174 patients) with KRAS-mutant LUAC and in patients treated with nivolumab in the CheckMate-057 phase 3 trial (0% vs 57...
May 17, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29771729/self-regulation-and-executive-functioning-as-related-to-survival-in-motor-neuron-disease-preliminary-findings
#5
Natasha E Garcia-Willingham, Abbey R Roach, Edward J Kasarskis, Suzanne C Segerstrom
OBJECTIVE: Disease progression varies widely among patients with motor neuron disease (MND). Patients with MND and coexisting dementia have shorter survival. However, implications of mild cognitive and behavioral difficulties are unclear. The present study examined the relative contribution of executive functioning and self-regulation difficulties on survival over a 6-year period among patients with MND, who scored largely within normal limits on cognitive and behavioral indices. METHODS: Patients with MND (N=37, age=59...
May 16, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29730900/strategies-for-the-enhancement-of-nutrition-practice-in-a-new-york-state-level-1-trauma-center-a-hospital-s-journey
#6
Lisa Musillo, Laryssa Marie Grguric, Edward Coffield, Frank Aversano, Jeremy Bosworth, Richard Batista
BACKGROUND: Provision of enteral nutrition (EN) support is historically inadequate in the critically ill population. An interdisciplinary approach utilizing various strategies has been shown to improve initiation of timely EN support. The purpose of this study was to examine whether the implementation of a series of interventions led by an interdisciplinary team was associated with changes in the initiation of nutrition support in a level 1 trauma center. METHODS: Patients admitted between 2009 and 2013 with isolated closed head trauma injuries were identified through the hospital's trauma center database...
December 18, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29686025/shorter-intensive-care-unit-stays-the-majority-of-post-intravenous-tpa-tissue-type-plasminogen-activator-symptomatic-hemorrhages-occur-within-12-hours-of-treatment
#7
Adam Chang, Edward J Llinas, Karen Chen, Rafael H Llinas, Elisabeth B Marsh
BACKGROUND AND PURPOSE: Symptomatic intracranial hemorrhage (sICH) is a life-threatening complication after treatment with intravenous tPA (tissue-type plasminogen activator) for acute stroke. Currently, patients are monitored for sICH in a neurocritical care unit or intensive care unit-like setting for 24 hours post-treatment-a costly and resource intensive practice. Because the half-life of tPA is much shorter than 24 hours, it is possible that the majority of patients do not require such intensive monitoring...
April 23, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29677403/indel-variation-in-the-regulatory-region-of-the-major-flowering-time-gene-lanftc1-is-associated-with-vernalisation-response-and-flowering-time-in-narrow-leafed-lupin-lupinus-angustifolius-l
#8
Candy M Taylor, Lars G Kamphuis, Weilu Zhang, Gagan Garg, Jens D Berger, Mahsa Mousavi-Derazmahalleh, Philipp E Bayer, David Edwards, Karam B Singh, Wallace A Cowling, Matthew N Nelson
Narrow-leafed lupin (Lupinus angustifolius L.) cultivation was transformed by two dominant vernalisation-insensitive, early flowering time loci known as Ku and Julius (Jul), which allowed expansion into shorter season environments. However, reliance on these loci has limited genetic and phenotypic diversity for environmental adaptation in cultivated lupin. We recently predicted that a 1,423 bp deletion in the cis-regulatory region of LanFTc1, a FLOWERING LOCUS T (FT) homologue, de-repressed expression of LanFTc1 and was the underlying cause of the Ku phenotype...
April 20, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29667154/reliability-and-feasibility-of-gait-initiation-centre-of-pressure-excursions-using-a-wii-%C3%A2-balance-board-in-older-adults-at-risk-of-failing
#9
James Lee, Graham Webb, Adam P Shortland, Rebecca Edwards, Charlotte Wilce, Gareth D Jones
BACKGROUND: Impairments in dynamic balance have a detrimental effect in older adults at risk of falls (OARF). Gait initiation (GI) is a challenging transitional movement. Centre of pressure (COP) excursions using force plates have been used to measure GI performance. The Nintendo Wii Balance Board (WBB) offers an alternative to a standard force plate for the measurement of CoP excursion. AIMS: To determine the reliability of COP excursions using the WBB, and its feasibility within a 4-week strength and balance intervention (SBI) treating OARF...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29608461/vilazodone-efficacy-in-subgroups-of-patients-with-major-depressive-disorder-a-post-hoc-analysis-of-four-randomized-double-blind-placebo-controlled-trials
#10
Susan Kornstein, Cheng-Tao Chang, Carl P Gommoll, John Edwards
The efficacy of antidepressants to treat major depressive disorder (MDD) varies by patient characteristics. This post-hoc analysis evaluated the effects of vilazodone across patient subgroups in adults with MDD. Data were pooled from four trials of vilazodone (NCT00285376, NCT00683592, NCT01473394, and NCT01473381). Mean change from baseline to week 8 in Montgomery-Åsberg Depression Rating Scale (MADRS) total score, MADRS response (≥50% total score improvement), and MADRS remission (total score≤10) were analyzed in the pooled intent-to-treat population (vilazodone=1254, placebo=964) and in subgroups of patients categorized by sex, age, MDD duration, recurrent episodes, baseline MADRS total score, and current episode duration...
March 30, 2018: International Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29604189/risk-timing-and-predictors-of-disease-flare-after-discontinuation-of-anti-tumor-necrosis-factor-tnf-therapy-in-children-with-polyarticular-forms-of-juvenile-idiopathic-arthritis-jia-in-clinical-inactive-disease
#11
Daniel J Lovell, Anne L Johnson, Bin Huang, Beth S Gottlieb, Paula W Morris, Yukiko Kimura, Karen Onel, Suzanne C Li, Alexei A Grom, Janalee Taylor, Hermine I Brunner, Jennifer L Huggins, James J Nocton, Kathleen A Haines, Barbara S Edelheit, Michael Shishov, Lawrence K Jung, Calvin B Williams, Melissa S Tesher, Denise M Costanzo, Lawrence S Zemel, Jason A Dare, Murray H Passo, Kaleo C Ede, Judyann C Olson, Elaine A Cassidy, Thomas A Griffin, Linda Wagner-Weiner, Jennifer E Weiss, Larry B Vogler, Kelly A Rouster-Stevens, Timothy Beukelman, Randy Q Cron, Daniel Kietz, Kenneth Schikler, Jay Mehta, Tracy V Ting, James W Verbsky, B Anne Eberhard, Steven Spalding, Chen Chen, Edward H Giannini
OBJECTIVE: Determine the frequency, time-to-flare, and predictors of disease flare upon withdrawal of anti-tumor necrosis factor (TNF) therapy in children with polyarticular forms of juvenile idiopathic arthritis (PF-JIA) who demonstrated ≥ 6 continuous months of clinical inactive disease (CID). METHODS: In 16 centers 137 patients with PF-JIA in CID on anti-TNF therapy (42% of whom were also on methotrexate [MTX]) were prospectively followed. If CID was maintained for the initial 6 months on study anti-TNF was stopped and patients assessed for flare at 1, 2, 3, 4, 6, and 8 months...
March 31, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29595965/engineering-an-fefe-hydrogenase-do-accessory-clusters-influence-o-2-resistance-and-catalytic-bias
#12
Giorgio Caserta, Cecilia Papini, Agnieszka Adamska-Venkatesh, Ludovic Pecqueur, Constanze Sommer, Edward Reijerse, Wolfgang Lubitz, Charles Gauquelin, Isabelle Meynial-Salles, Debajyoti Pramanik, Vincent Artero, Mohamed Atta, Melisa Del Barrio, Bruno Faivre, Vincent Fourmond, Christophe Léger, Marc Fontecave
[FeFe]-hydrogenases, HydAs, are unique biocatalysts for proton reduction to H2. However, they suffer from a number of drawbacks for biotechnological applications: size, number and diversity of metal cofactors, oxygen sensitivity. Here we show that HydA from Megasphaera elsdenii (MeHydA) displays significant resistance to O2. Further-more, we produced a shorter version of this enzyme (MeH-HydA), lacking the N-terminal domain harbouring the accessory FeS clusters. As shown by detailed spectroscopic and biochemical characterization, MeH-HydA displays the following interesting properties...
March 29, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29579363/gout-severity-socioeconomic-status-and-work-absence-a-cross-sectional-study-in-primary-care
#13
Zachary Bowen-Davies, Sara Muller, Christian D Mallen, Richard A Hayward, Edward Roddy
OBJECTIVES: To examine the association between gout severity and (i) socioeconomic status; (ii) work absence. METHODS: Postal questionnaires were sent to adults registered with 20 general practices who had consulted with gout or been prescribed allopurinol or colchicine in the preceding two years. Gout severity was defined using proxy measures: number of attacks, history of oligo/polyarticular attacks, disease duration, and allopurinol use. Socioeconomic status (SES) was defined using the English index of multiple deprivation (IMD) (area-level) using self-reported educational attainment (individual level)...
March 26, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29577898/reproductive-endocrinology-of-environmental-nitrate
#14
REVIEW
Thea M Edwards, Heather J Hamlin
Nitrate is a widespread contaminant of aquatic ecosystems and drinking water. It is also broadly active in organismal physiology, and as such, has the potential to both enhance and disrupt normal physiological function. In animals, nitrate is a proposed endocrine disrupter that is converted in vivo to nitrite and nitric oxide. Nitric oxide, in particular, is a potent cell signaling molecule that participates in diverse biological pathways and events. Here, we review in vivo nitrate cycling and downstream mechanistic physiology, with an emphasis on reproductive outcomes...
March 22, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29555740/agricultural-origins-on-the-anatolian-plateau
#15
Douglas Baird, Andrew Fairbairn, Emma Jenkins, Louise Martin, Caroline Middleton, Jessica Pearson, Eleni Asouti, Yvonne Edwards, Ceren Kabukcu, Gökhan Mustafaoğlu, Nerissa Russell, Ofer Bar-Yosef, Geraldine Jacobsen, Xiaohong Wu, Ambroise Baker, Sarah Elliott
This paper explores the explanations for, and consequences of, the early appearance of food production outside the Fertile Crescent of Southwest Asia, where it originated in the 10th/9th millennia cal BC. We present evidence that cultivation appeared in Central Anatolia through adoption by indigenous foragers in the mid ninth millennium cal BC, but also demonstrate that uptake was not uniform, and that some communities chose to actively disregard cultivation. Adoption of cultivation was accompanied by experimentation with sheep/goat herding in a system of low-level food production that was integrated into foraging practices rather than used to replace them...
March 19, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29532329/long-term-costs-and-health-consequences-of-issuing-shorter-duration-prescriptions-for-patients-with-chronic-health-conditions-in-the-english-nhs
#16
Adam Martin, Rupert Payne, Edward Cf Wilson
BACKGROUND: The National Health Service (NHS) in England spends over £9 billion on prescription medicines dispensed in primary care, of which over two-thirds is accounted for by repeat prescriptions. Recently, GPs in England have been urged to limit the duration of repeat prescriptions, where clinically appropriate, to 28 days to reduce wastage and hence contain costs. However, shorter prescriptions will increase transaction costs and thus may not be cost saving. Furthermore, there is evidence to suggest that shorter prescriptions are associated with lower adherence, which would be expected to lead to lower clinical benefit...
June 2018: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/29527221/convergent-evolution-of-slick-coat-in-cattle-through-truncation-mutations-in-the-prolactin-receptor
#17
Laercio R Porto-Neto, Derek M Bickhart, Antonio J Landaeta-Hernandez, Yuri T Utsunomiya, Melvin Pagan, Esbal Jimenez, Peter J Hansen, Serdal Dikmen, Steven G Schroeder, Eui-Soo Kim, Jiajie Sun, Edward Crespo, Norman Amati, John B Cole, Daniel J Null, Jose F Garcia, Antonio Reverter, William Barendse, Tad S Sonstegard
Evolutionary adaptations are occasionally convergent solutions to the same problem. A mutation contributing to a heat tolerance adaptation in Senepol cattle, a New World breed of mostly European descent, results in the distinct phenotype known as slick, where an animal has shorter hair and lower follicle density across its coat than wild type animals. The causal variant, located in the 11th exon of prolactin receptor , produces a frameshift that results in a truncated protein. However, this mutation does not explain all cases of slick coats found in criollo breeds...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29521718/clinical-efficacy-and-safety-profile-of-micropulse-transscleral-cyclophotocoagulation-in-refractory-glaucoma
#18
Alice L Williams, Marlene R Moster, Kamran Rahmatnejad, Arthur F Resende, Teresa Horan, Michael Reynolds, Edward Yung, Benjamin Abramowitz, Sarah Kuchar, Michael Waisbourd
PURPOSE: To investigate the clinical efficacy and safety profile of micropulse transscleral cyclophotocoagulation (MP-CPC) in patients with refractory glaucoma. MATERIALS AND METHODS: Retrospective case series of 79 consecutive patients who underwent MP-CPC at the Wills Eye Hospital from March 23, 2014 to June 23, 2016 and who had at least 3 months of follow-up. Treatment success was defined as an intraocular pressure (IOP) of 6 to 21 mm Hg or a reduction of IOP by 20%...
May 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29518274/trait-differentiation-and-adaptation-of-plants-along-elevation-gradients
#19
REVIEW
Aud H Halbritter, Simone Fior, Irene Keller, Regula Billeter, Peter J Edwards, Rolf Holderegger, Sophie Karrenberg, Andrea R Pluess, Alex Widmer, Jake M Alexander
Studies of genetic adaptation in plant populations along elevation gradients in mountains have a long history, but there has until now been neither a synthesis of how frequently plant populations exhibit adaptation to elevation nor an evaluation of how consistent underlying trait differences across species are. We reviewed studies of adaptation along elevation gradients (i) from a meta-analysis of phenotypic differentiation of three traits (height, biomass and phenology) from plants growing in 70 common garden experiments; (ii) by testing elevation adaptation using three fitness proxies (survival, reproductive output and biomass) from 14 reciprocal transplant experiments; (iii) by qualitatively assessing information at the molecular level, from 10 genomewide surveys and candidate gene approaches...
March 8, 2018: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/29501736/effects-of-refractory-gradients-and-ablation-on-fibrillatory-activity
#20
Edward J Ciaccio, Nicholas S Peters, Hasan Garan
BACKGROUND: The mechanisms involved in onset, maintenance, and termination of atrial fibrillation are not well understood. A biophysical model could be useful to determine how the events unfold. METHOD: A two-dimensional cellular automaton consisting of 576 × 576 grid nodes was implemented to demonstrate the types of electrical activity that may occur in compromised atrial substrate. Electrical activation between nodes was made anisotropic (2:1), and the refractory period (RP) was adjusted from 74 to 192 ms in the spatial domain...
April 1, 2018: Computers in Biology and Medicine
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