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https://www.readbyqxmd.com/read/29342074/characterization-of-an-additive-manufactured-tial-alloy-steel-joint-produced-by-electron-beam-welding
#1
Gloria Basile, Giorgio Baudana, Giulio Marchese, Massimo Lorusso, Mariangela Lombardi, Daniele Ugues, Paolo Fino, Sara Biamino
In this work, the characterization of the assembly of a steel shaft into a γ-TiAl part for turbocharger application, obtained using Electron Beam Welding (EBW) technology with a Ni-based filler, was carried out. The Ti-48Al-2Nb-0.7Cr-0.3Si (at %) alloy part was produced by Electron Beam Melting (EBM). This additive manufacturing technology allows the production of a lightweight part with complex shapes. The replacement of Nickel-based superalloys with TiAl alloys in turbocharger automotive applications will lead to an improvement of the engine performance and a substantial reduction in fuel consumption and emission...
January 17, 2018: Materials
https://www.readbyqxmd.com/read/29338713/lncrna-dancr-involved-osteolysis-after-total-hip-arthroplasty-by-regulating-foxo1-expression-to-inhibit-osteoblast-differentiation
#2
Zhenyu Tang, Zongming Gong, Xiaoliang Sun
BACKGROUND: Aseptic loosening of artificial hip joint is a major complication affecting the long-term use of the artificial hip joint, and is the main cause of joint replacement failure. However, the mechanism of aseptic loosening of THR has not yet cleared. The aim of this study was to investigate the underlying mechanism of DANCR in osteoblast differentiation (OD). METHODS: We detected the expressions of DANCR and FOXO1 in clinical samples and mesenchymal stem cells (MSCs) by qRT-PCR and western blotting...
January 16, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/29334560/proposed-modification-of-the-8th-edition-of-the-ajcc-staging-system-for-pancreatic-ductal-adenocarcinoma
#3
Si Shi, Jie Hua, Chen Liang, Qingcai Meng, Dingkong Liang, Jin Xu, Quanxing Ni, Xianjun Yu
OBJECTIVE: The aim of this study was to improve the 8th edition (8th) of the American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC). BACKGROUND: The new 8th AJCC staging system for PDAC was released in October, 2016, and will be applied in clinical practice in 2018. METHODS: Two large cohorts were included in this analysis. One consisted of 45,856 PDAC patients in the Surveillance, Epidemiology, and End Results (SEER) database (2004-2014), and the other consisted of 3166 PDAC patients in the Fudan University Shanghai Cancer Center (FUSCC) database (2005-2015)...
January 12, 2018: Annals of Surgery
https://www.readbyqxmd.com/read/29329443/bone-formation-in-ankylosing-spondylitis-during-anti-tumour-necrosis-factor-therapy-imaged-by-18f-fluoride-positron-emission-tomography
#4
Stefan T G Bruijnen, Nicki J F Verweij, Leonie M van Duivenvoorden, Nathalie Bravenboer, Dominique L P Baeten, Christiaan J van Denderen, Irene E van der Horst-Bruinsma, Alexandre E Voskuyl, Martijn Custers, Peter M van de Ven, Joost C J Bot, Bouke J H Boden, Adriaan A Lammertsma, Otto S H Hoekstra, Pieter G H M Raijmakers, Conny J van der Laken
Objectives: Excessive bone formation is an important hallmark of AS. Recently it has been demonstrated that axial bony lesions in AS patients can be visualized using 18F-fluoride PET-CT. The aim of this study was to assess whether 18F-fluoride uptake in clinically active AS patients is related to focal bone formation in spine biopsies and is sensitive to change during anti-TNF treatment. Methods: Twelve anti-TNF-naïve AS patients [female 7/12; age 39 years (SD 11); BASDAI 5...
January 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29321799/independent-and-combined-effects-of-environmental-factors-and-mir-126-mir-143-and-mir-145-on-the-risk-of-coronary-heart-disease
#5
Da-Cen Lin, Jia-Bing Lin, Zhou Chen, Rong Chen, Chun-Yu Wan, Shao-Wei Lin, Qi-Shuang Ruan, Huang-Yuan Li, Si-Ying Wu
Objective: To evaluate the effects of environmental factors and microRNAs (miRNAs) (miR-126, miR-143, and miR-145) on the risk of coronary heart disease (CHD). Methods: A frequency-matched case-control study (450 patients, 450 controls) was conducted from April 2014 to December 2016 in Fuzhou City, China. Environmental factors were investigated using a self-administered questionnaire, and the expression levels of miR-126, miR-143, and miR-145 were determined by quantitative real-time Polymerase Chain Reaction (PCR) in peripheral blood mononuclear cells...
November 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29303472/biomechanics-of-unilateral-and-bilateral-sacroiliac-joint-stabilization-laboratory-investigation
#6
Derek P Lindsey, Robin Parrish, Mukund Gundanna, Jeremi Leasure, Scott A Yerby, Dimitriy Kondrashov
OBJECTIVE Bilateral symptoms have been reported in 8%-35% of patients with sacroiliac (SI) joint dysfunction. Stabilization of a single SI joint may significantly alter the stresses on the contralateral SI joint. If the contralateral SI joint stresses are significantly increased, degeneration may occur; alternatively, if the stresses are significantly reduced, bilateral stabilization may be unnecessary for patients with bilateral symptoms. The biomechanical effects of 1) unilateral stabilization on the contralateral SI joint and 2) bilateral stabilization on both SI joints are currently unknown...
January 5, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29302376/clinicopathological-significance-of-large-tumor-suppressor-lats-expression-in-gastric-cancer
#7
Myoung Won Son, Geum Jong Song, Si-Hyong Jang, Soon Auck Hong, Mee-Hye Oh, Ji-Hye Lee, Moo Jun Baek, Moon Soo Lee
Purpose: The aims of this study were to evaluate the expression of the large tumor suppressor (LATS) genes LATS1 and LATS2 by immunohistochemical staining of gastric cancer, and to evaluate the clinicopathological significance of LATS expression and its correlation with overall survival (OS). Materials and Methods: LATS1 and LATS2 expression in a tissue microarray was detected by immunohistochemistry, using 264 gastric cancer specimens surgically resected between July 2006 and December 2009...
December 2017: Journal of Gastric Cancer
https://www.readbyqxmd.com/read/29284539/prognostic-values-of-the-integrated-model-incorporating-the-volume-of-metastatic-regional-cervical-lymph-node-and-pretreatment-serum-epstein-barr-virus-dna-copy-number-in-predicting-distant-metastasis-in-patients-with-n1-nasopharyngeal-carcinoma
#8
Ji-Jin Yao, Guan-Qun Zhou, Ya-Qin Wang, Si-Yang Wang, Wang-Jian Zhang, Ya-Nan Jin, Fan Zhang, Li Li, Li-Zhi Liu, Zhi-Bin Cheng, Jun Ma, Zhen-Yu Qi, Ying Sun
BACKGROUND: According to the 7th edition of the American Joint Committee on Cancer (AJCC) staging system, over 50% of patients with nasopharyngeal carcinoma (NPC) have N1 disease at initial diagnosis. However, patients with N1 NPC are relatively under-researched, and the metastasis risk of this group is not well-stratified. This study aimed to evaluate the prognostic values of gross tumor volume of metastatic regional lymph node (GTVnd) and pretreatment serum copy number of Epstein-Barr virus (EBV) DNA in predicting distant metastasis of patients with N1 NPC, and to develop an integrated prognostic model that incorporates GTVnd and EBV DNA copy number for this group of patients...
December 29, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/29249953/learning-peri-saccadic-remapping-of-receptive-field-from-experience-in-lateral-intraparietal-area
#9
Xiao Wang, Yan Wu, Mingsha Zhang, Si Wu
Our eyes move constantly at a frequency of 3-5 times per second. These movements, called saccades, induce the sweeping of visual images on the retina, yet we perceive the world as stable. It has been suggested that the brain achieves this visual stability via predictive remapping of neuronal receptive field (RF). A recent experimental study disclosed details of this remapping process in the lateral intraparietal area (LIP), that is, about the time of the saccade, the neuronal RF expands along the saccadic trajectory temporally, covering the current RF (CRF), the future RF (FRF), and the region the eye will sweep through during the saccade...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29240523/injectable-platelet-rich-fibrin-using-the-low-speed-centrifugation-concept-improves-cartilage-regeneration-when-compared-to-platelet-rich-plasma
#10
Mustafa Abd El Raouf, Xuzhu Wang, Si Miusi, Jihua Chai, Abdel Basit Mohamed AbdEl-Aal, Mekkawy M Nefissa Helmy, Shahram Ghanaati, Joseph Choukroun, Elisa Choukroun, Yufeng Zhang, Richard J Miron
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit's knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits...
December 14, 2017: Platelets
https://www.readbyqxmd.com/read/29233110/accounting-for-misclassification-bias-of-binary-outcomes-due-to-underscreening-a-sensitivity-analysis
#11
Nanhua Zhang, Si Cheng, Lilliam Ambroggio, Todd A Florin, Maurizio Macaluso
BACKGROUND: Diagnostic tests are performed in a subset of the population who are at higher risk, resulting in undiagnosed cases among those who do not receive the test. This poses a challenge for estimating the prevalence of the disease in the study population, and also for studying the risk factors for the disease. METHODS: We formulate this problem as a missing data problem because the disease status is unknown for those who do not receive the test. We propose a Bayesian selection model which models the joint distribution of the disease outcome and whether testing was received...
December 12, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29218932/-research-progress-of-bixie
#12
REVIEW
Chong Chen, Chen-Hong Zeng, Si-Qi Zhang, Li Wei
The Dioscorea hypoglauca rhizome and D. spongiosa rhizome in "China Pharmacopoeia" are often used as Bixie in clinically, with the function of removing dampness, clearing away turbidness and dispelling wind to remove pain, and has been widely used in stranguria marked by chyluria, joint stiffness and rheumatic arthralgia. It has obvious curative effect and broad application prospect. However, in recent years the progress of research is slow for its miscellaneous sources, chaotic varieties and lack of relevant quality assessment...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29185771/centimeter-long-single-crystalline-si-nanowires
#13
Bing-Chang Zhang, Hui Wang, Le He, Cai-Jun Zheng, Jiansheng Jie, Yeshayahu Lifshitz, Shuit-Tong Lee, Xiao-Hong Zhang
The elongation of free-standing one-dimensional (1D) functional nanostructures into lengths above the millimeter range has brought new practical applications as they combine the remarkable properties of nanostructured materials with macroscopic lengths. However, it remains a big challenge to prepare 1D silicon nanostructures, one of the most important 1D nanostructures, with lengths above the millimeter range. Here we report the unprecedented preparation of ultra-long single-crystalline Si nanowires with length up to 2 cm, which can function as the smallest active material to facilitate the miniaturization of macroscopic devices...
November 29, 2017: Nano Letters
https://www.readbyqxmd.com/read/29179754/quantitative-evaluation-of-subchondral-bone-microarchitecture-in-knee-osteoarthritis-using-3t-mri
#14
Chenglei Liu, Chang Liu, Xvhua Ren, Liping Si, Hao Shen, Qian Wang, Weiwu Yao
BACKGROUND: Osteoarthritis (OA) is now increasingly recognized as being related to the whole joint instead of the cartilage alone. In particular, the importance of subchondral bone in OA pathogenesis has drawn a lot of interest. The aim of this study is to investigate subchondral bone microstructural features in two femoral condyles of human knee osteoarthritis. METHODS: Eighty subjects were enrolled in our study and divided into three groups: without OA (group 0), mild OA (group 1), and severe OA (group 2)...
November 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29179748/quantifying-bone-marrow-inflammatory-edema-in-the-spine-and-sacroiliac-joints-with-thresholding
#15
Ioanna Chronaiou, Ruth S Thomsen, Else M Huuse, Leslie R Euceda, Susanne J Pedersen, Mari Hoff, Beathe Sitter
BACKGROUND: Psoriatic Arthritis (PsA) is a chronic inflammatory arthritis that develops in patients with psoriasis. Inflammatory edema in the spine may reflect subclinical disease activity and be a predictor of radiographic progression. A semi-quantitative method established by the spondyloarthritis research consortium of Canada (SPARCC) is commonly used to assess the disease activity in MR images of the spine. This study aims to evaluate thresholding for quantification of subtle bone marrow inflammation in the spine and the sacroiliac (SI) joints of patients with PsA and compare it with the SPARCC scoring system...
November 28, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29176772/symphyseal-fixation-in-open-book-injuries-cannot-fully-compensate-anterior-si-joint-injury-a-biomechanical-study-in-a-two-leg-alternating-load-model
#16
Fabian M Stuby, Mark Lenz, Stefan Doebele, Yash Agarwal, Hristo Skulev, Björn G Ochs, Jörn Zwingmann, Boyko Gueorguiev
INTRODUCTION: In open book injuries type Tile B1.1 or B1.2 also classified as APC II (anteroposterior compression), it remains controversial, if a fixation of the anterior ring provides sufficient stability or a fixation of the posterior ring should be included. Therefore the relative motion at the sacroiliac joint was quantified in a two-leg alternating load biomechanical pelvis model in the intact, the injured and the restored pelvis. METHODS: Fresh-frozen intact (I) pelvises (n = 6) were subjected to a non-destructive cyclic test under sinosuidal axial two-leg alternating load with progressively increasing amplitude...
2017: PloS One
https://www.readbyqxmd.com/read/29175641/effect-of-tibia-marker-placement-on-knee-joint-kinematic-analysis
#17
Yuhui Wen, Hongshi Huang, Yuanyuan Yu, Si Zhang, Jie Yang, Yingfang Ao, Shihong Xia
Variability of kinematic measures determined by different marker sets among sites participating in a collaborative study is necessary for determining the reliability of a multi-site gait analysis research. We compared knee kinematics based on different marker sets on the tibia, calculating by segmental optimization (SO) and multi-body optimization (MBO) methods respectively, in order to assess the effect of marker locations on the methods. 11 healthy subjects participated in the study with 33 markers attached to the lower extremity segments, and 4 groups were identified according to markers on the tibia...
November 22, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29159672/patellar-tracking-should-be-taken-into-account-when-measuring-radiographic-parameters-for-recurrent-patellar-instability
#18
Si Heng Sharon Tan, Mazen M Ibrahim, Zhaojie Joel Lee, Yen Kit Michael Chee, James H Hui
PURPOSE: To date, many radiographic parameters on patellar instability have their measurements taken statically, and have not been studied in various degrees of flexion according to the patellar tracking. There are also limited data regarding the use of these parameters in predicting recurrent patellar dislocation. The current study aims to review the radiographic parameters of the patellofemoral joint in different degrees of knee flexion and to correlate them with the presence of recurrent instability...
November 20, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29143041/joint-experimental-and-theoretical-studies-of-the-surprising-stability-of-the-aryl-pentazole-upon-noncovalent-binding-to-%C3%AE-cyclodextrin
#19
Yu-Zhang Yang, Xiao-Feng Liu, Ru-Bo Zhang, Si-Ping Pang
Herein, binding of the β-cyclodextrin (β-CD) host to the unstable aryl pentazole guest has been confirmed experimentally and theoretically. After the confinement of aryl pentazole, electron density reorganization was studied by M06-2X dispersion-corrected DFT and further reflected in the characteristic shift in the NMR spectra. Among the host-guest complexes, the inclusion complex is favored with the phenyl ring expectedly encapsulated within the cavity through noncovalent interactions such as hydrogen bonding, C-Hπ, and the special Csp(2)-HH-Csp(3) bonding discovered by the NBO, QTAIM, and NCI-RDG theories...
November 16, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29119479/utility-of-ct-imaging-in-differentiating-sacroiliitis-associated-with-spondyloarthritis-from-gouty-sacroiliitis-a-retrospective-study
#20
Jyoti Panwar, Pulukool Sandhya, Madhavi Kandagaddala, Aswin Nair, Visalakshi Jeyaseelan, Debashish Danda
Sacroiliitis is one of the criteria for classification as spondyloarthritis (SpA), though not unique to SpA. Other conditions including gout may be erroneously diagnosed as SpA due to sacroiliitis. The objective was to identify specific CT findings in sacroiliitis associated with SpA and gout. In this retrospective study, CT images of patients with sacroiliitis and clinical diagnosis of gout or SpA from 2010 to 2015 were independently reviewed by two radiologists, blinded to diagnosis. Axial and coronal oblique images were analyzed for characteristics of erosions...
November 8, 2017: Clinical Rheumatology
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