Read by QxMD icon Read

Changing moles

Val A Fajardo, John S Mikhaeil, Cameron F Leveille, A Russell Tupling, Paul J LeBlanc
BACKGROUND: An increase in phosphatidylcholine:phosphatidylethanolamine (PC:PE) and a decrease in fatty acyl chain length, monounsaturated:polyunsaturated (MUFA:PUFA) fatty acyl ratio reduces SERCA activity in liposomes and in mouse models of obesity and muscular dystrophy. We have previously shown that maximal SERCA activity is significantly reduced in mechanically overloaded (OVL) plantaris, however, whether changes in PC:PE ratio or fatty acyl composition may contribute to the alterations in maximal SERCA activity remain unknown...
March 13, 2018: Lipids in Health and Disease
Logan E Mitchell, John C Lin, David R Bowling, Diane E Pataki, Courtenay Strong, Andrew J Schauer, Ryan Bares, Susan E Bush, Britton B Stephens, Daniel Mendoza, Derek Mallia, Lacey Holland, Kevin R Gurney, James R Ehleringer
Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's metropolitan Salt Lake Valley. We examine "excess" CO2 above background conditions resulting from local emissions and meteorological conditions. We ascribe CO2 trends to changes in emissions, since we did not find long-term trends in atmospheric mixing proxies...
March 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
V N Manskikh, O A Averina, A I Nikiforova
The naked mole rat (Heterocephalus glaber, Rüppell, 1842) is a unique eusocial rodent with unusually long lifespan. Therefore, the study of spontaneous and experimentally induced pathologies in these animals is one of the most important tasks of gerontology. Various infections, noninfectious pathologies (including age-dependent changes), and tumors have been described in the naked mole rat. The most frequent pathologies are traumas (bite wounds), purulent and septic complications of traumatic injuries, renal tubular calcinosis, chronic progressive nephropathy, hepatic hemosiderosis, testicular interstitial cell hyperplasia, calcinosis cutis, cardiomyopathy, and dysbiosis-related infectious lesions of the digestive system...
December 2017: Biochemistry. Biokhimii︠a︡
M V Skulachev, V P Skulachev
(i) In 2015-2017 we compared possible reasons for longevity of two mammalian highly social species, i.e. naked mole rats and humans. We proposed that in both cases longevity is a result of neoteny, prolongation of youth by deceleration of late ontogeny (Skulachev, V. P. (2015) Abst. 11th Conf. on Mitochondrial Physiology (MiP2015), Lucni Bouda, Czech Republic, pp. 64-66; Skulachev, V. P., Holtze, S., Vyssokikh, M. Y., Bakeeva, L. E., Skulachev, M. V., Markov, A. V., Hildebrandt, T. B., and Sadovnichii, V. A...
December 2017: Biochemistry. Biokhimii︠a︡
Nadezhda Palkina, Olga Sergeeva, Tatiana Ruksha, Ivan Artyukhov
Objective: The Melanoma Screening Day Campaign started in the Russian Federation in 2006. In the present study, we analyzed the 2015-2016 survey questionnaire data acquired from screened individuals in the city of Krasnoyarsk in eastern Siberia, which has a population of one million, in order to understand the level of awareness regarding melanoma/ skin cancer prevention and early diagnosis. Methods: Individuals were enrolled in the screening campaign by mass media advertising. Free whole-body examinations were provided by the doctors, and the standardized questionnaire forms (n=444) were completed to obtain relevant demographic, epidemiological, and clinical data...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Pei-Gao Duan, Shi-Chang Li, Jia-Li Jiao, Feng Wang, Yu-Ping Xu
Supercritical water gasification (SCWG) of the microalga Chlorella pyrenoidosa was examined with a catalyst mixture of Ru/C and Rh/C in a mass ratio of 1:1. The influences of temperature (380-600°C), water density (0-0.197g/cm3 ), and catalyst loading (0-20wt%) on the yields and composition of the gaseous products and the gasification efficiency were examined. The temperature and water density significantly affected the SCWG of the microalgae. The hydrogen gasification efficiency was more dependent on the temperature, while the carbon gasification efficiency was more dependent on the water density...
February 22, 2018: Science of the Total Environment
Urika Joneborg, Yasin Folkvaljon, Nikos Papadogiannakis, Mats Lambe, Lena Marions
BACKGROUND: Reported incidence rates of hydatidiform mole (HM) show wide geographic and temporal variations, making reliable international comparisons difficult. The aim of the current study was to examine temporal trends in the incidence of HM and post-molar gestational trophoblastic neoplasia (GTN) in Stockholm County. MATERIAL AND METHODS: Data of all women with a diagnosis of HM in Stockholm County 1991-2010 was collected. The incidence of HM was assessed both in relation to number of births and viable conceptions (births and pregnancy terminations)...
February 16, 2018: Acta Oncologica
Jae Hyeon Park, Tae Whan Kim
Self-heating effect (SHE) on the electrical characteristics of fin field-effect transistors (FinFETs) model with a strained Si channel was investigated by using a three-dimensional simulation tool. Strain was applied from 0.1 to 2.0 GPa by changing Si mole fraction of the Si1-xGex. Simulation results showed that the drain current of the strained Si FinFETs increased with increasing applied strain from 0.5 to 2.0 GPa. The drain current of the FinFETs under strain of 2.0 GPa increased up to 20.59 μA. While the drain current of the FinFETs without a SHE increased with increasing strain, the increase of the drain current generating from the strain interrupted the applications for the practical device operation due to a large SHE...
March 1, 2018: Journal of Nanoscience and Nanotechnology
Yang Zhao, Alexander Tyshkovskiy, Daniel Muñoz-Espín, Xiao Tian, Manuel Serrano, Joao Pedro de Magalhaes, Eviatar Nevo, Vadim N Gladyshev, Andrei Seluanov, Vera Gorbunova
Cellular senescence is an important anticancer mechanism that restricts proliferation of damaged or premalignant cells. Cellular senescence also plays an important role in tissue remodeling during development. However, there is a trade-off associated with cellular senescence as senescent cells contribute to aging pathologies. The naked mole rat (NMR) ( Heterocephalus glaber ) is the longest-lived rodent that is resistant to a variety of age-related diseases. Remarkably, NMRs do not show aging phenotypes until very late stages of their lives...
February 5, 2018: Proceedings of the National Academy of Sciences of the United States of America
Basilius Thalmann, Urs von Gunten, Ralf Kaegi
Ozonation can be applied to mitigate the discharge of organic micropollutants from municipal wastewater treatment plants (WWTPs) to the aquatic environment. The toxicity of metals also present in WWTP effluents strongly depends on their speciation. Therefore, knowledge on the change of the metal speciation during ozonation of a WWTP effluent is essential to assess possible negative impacts. The kinetics and the stoichiometries of the reactions of ozone with three metal sulfides (ZnS, CuS and CdS) and metal-ethylenediaminetetraacetate (EDTA)/nitriloriacetic acid (NTA) complexes of Cu(II), Cd(II), Ni(II), Zn(II), Mg(II) and Pb(II) were investigated...
February 6, 2018: Water Research
Quan Chi, Zhixiong Li, Juan Huang, Jieyao Ma, Xian Wang
The binding information of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) with bovine and human serum albumins was investigated and characterized in details by using a combination method of electrospray ionization mass spectrometry (ESI-MS), fluorescence, circular dichroism (CD) and molecular docking (MD). The ESI-MS analysis revealed that maximally eight PFOA or PFOS molecules could bind to serum albumins at high mole ratios of PFOA/PFOS. Association constants were measured by ESI-MS and suggested that PFOS had a better binding affinity than PFOA...
February 3, 2018: Chemosphere
Eric Jauniaux, Maria Memtsa, Jemma Johns, Jackie A Ross, Davor Jurkovic
OBJECTIVE: The majority of complete hydatidiform moles (CHM) are detected on ultrasound examination by the end of the first trimester when they present as multiple sonolucent cysts. To better understand the pathophysiology of this unique placental pathology and improve its prenatal diagnosis and management we have reviewed the ultrasound features of CHM before the appearance of cystic changes. STUDY DESIGN: We searched our database to identify all women diagnosed with a complete hydatidiform mole confirmed by histopathology who had an ultrasound examination before 9 weeks' gestation...
February 2018: Placenta
Yuyuan Zhang, Kimberly de La Harpe, Mahesh Hariharan, Bern Kohler
The photophysics of several mono- and oligonucleotides were investigated in a deep eutectic solvent for the first time. The solvent glyceline, prepared as a 1 : 2 mole ratio mixture of choline chloride and glycerol, was used to study excited-state deactivation in a non-aqueous solvent by the use of steady-state and time-resolved spectroscopy. DNA strands in glyceline retain the secondary structures that are present in aqueous solution to some degree, thus enabling a study of the effects of solvent properties on the excited states of stacked bases and stacked base pairs...
January 31, 2018: Faraday Discussions
Matthew E Pamenter, Gigi Y Lau, Jeffrey G Richards, William K Milsom
Mitochondrial respiration and ATP production are compromised by hypoxia. Naked mole rats (NMRs) are among the most hypoxia-tolerant mammals and reduce metabolic rate in hypoxic environments; however, little is known regarding mitochondrial function during in vivo hypoxia exposure in this species. To address this knowledge gap, we asked whether the function of NMR brain mitochondria exhibits metabolic plasticity during acute hypoxia. Respirometry was utilized to assess whole-animal oxygen consumption rates and high-resolution respirometry and was utilized to assess electron transport system (ETS) function in saponin-permeabilized NMR brain...
December 28, 2017: Journal of Experimental Biology
Samuel C R Sherratt, R Preston Mason
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) differentially influence lipid oxidation, signal transduction, fluidity, and cholesterol domain formation, potentially due in part to distinct membrane interactions. We used small angle x-ray diffraction to evaluate the EPA and DHA effects on membrane structure. Membrane vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and cholesterol (C) (0.3C:POPC mole ratio) were prepared and treated with vehicle, EPA, or DHA (1:10 mole ratio to POPC)...
January 17, 2018: Chemistry and Physics of Lipids
Soheil S Dadras, Jun Lu, Artur Zembowicz, Thomas J Flotte, Martin C Mihm
The presence of enlarged epithelioid/spindled nests located deep in the reticular dermis of a biphasic melanocytic neoplasm can mimic melanoma arising in a preexisting nevus, causing over-interpretation of malignancy. We aimed to define the clinicopathologic significance of epithelioid/spindled nests in melanocytic nevi. Retrospectively using clinical and histologic information, we characterized 121 patients with a single lesion showing epithelioid/spindled melanocytes in the reticular dermis or subcutaneous fat, surrounded by melanophages, sometimes blending in with the adnexa...
January 17, 2018: Journal of Cutaneous Pathology
Biswajit Bhattacharyya, Kushagra Gahlot, Ranjani Viswanatha, Anshu Pandey
We study the optical properties of copper containing II-VI alloy quantum dots (CuxZn¬yCd1-x-ySe). Copper mole fractions within the host are varied from 0.001 to 0.35. No impurity phases are observed over this composition range and the formation of secondary phases of copper selenide are observed only at xCu > 0.45. The optical absorption and emission spectra of these materials are observed to be a strong function of xCu, and provide information regarding composition induced impurity-impurity interactions...
January 16, 2018: Journal of Physical Chemistry Letters
Bang Xiao, Shiyong Wang, Guoshi Yang, Xiaoxi Sun, Shanmin Zhao, Lifang Lin, Jishuai Cheng, Wenjing Yang, Wei Cong, Wei Sun, Guanghan Kan, Shufang Cui
Background/Aims: Naked mole rats (NMRs) spend their lives in burrow systems containing very low levels of oxygen, indicating long-term hypoxic exposure, and suggesting that pathological changes caused by hypoxia are attenuated or absent in this hypoxia-tolerant species. The mechanisms underlying NMRs hypoxia tolerance remain poorly understood. In this study, we explored whether hypoxia inducible factor 1α (HIF-1α), and vascular endothelial growth factor A (VEGFA) play a role in NMRs adaption to hypoxia...
December 15, 2017: Oncotarget
Weimin Wang, Randilynn Christensen, Brittany Curtis, Steve W Martin, John Kieffer
Glasses are promising candidate materials for all-solid-state electrolytes for rechargeable batteries due to their outstanding mechanical stability, wide electrochemical stability range, and open structure for potentially high conductivity. Mechanical stiffness and ionic conductivity are two key parameters for solid-state electrolytes. In this study, we investigate two mixed-network former glass systems, sodium borosilicate 0.2Na2O + 0.8[xBO1.5 + (1 - x)SiO2] and sodium borogermanate 0.2Na2O + 0.8[xBO1.5 + (1 - x)GeO2] glasses...
December 20, 2017: Physical Chemistry Chemical Physics: PCCP
A K Rzepecki, N Jain, Y Ali, L Chavez, J Choi, B Schlosser, E Liko-Hazizi, S M Friedewald, J K Robinson
Background: Invasive melanoma, a lethal form of skin cancer, is the seventh most common cancer in women. Factors such as a history of indoor tanning or sunburn and a personal or family history of skin cancer increase a woman's risk of developing a melanoma. Objective: Because the majority of melanomas occur in patients age 40 years or older, which is the age that is recommended for women to begin screening mammograms, the mammogram experience could be used to promote early detection of melanoma by introducing skin self-examinations (SSE) to a population of women who are already invested in preventive health...
December 2017: International Journal of Women's Dermatology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"