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https://www.readbyqxmd.com/read/28937145/immunoreduction-of-ocular-surface-tumours-with-intralesional-interferon-alpha-2a
#1
S E Kim, S M Salvi
PurposeTo share our initial experience in the use of intralesional interferon alpha-2a at primary presentation in ocular surface tumours as a method of immunoreduction prior to definitive surgical management.MethodsCase series of patients referred to Sheffield Ocular Oncology Service with rapidly growing ocular surface tumours, treated with intralesional interferon alpha-2a at first presentation prior to definitive surgical management.ResultsAll three patients, two with conjunctival melanoma and one with ocular surface squamous neoplasia (OSSN) demonstrated immunoreduction of tumour without any adverse side effects...
September 22, 2017: Eye
https://www.readbyqxmd.com/read/28935400/adjuvant-sunitinib-in-high-risk-patients-with-uveal-melanoma-comparison-with-institutional-controls
#2
Matias E Valsecchi, Marlana Orloff, Rino Sato, Inna Chervoneva, Carol L Shields, Jerry A Shields, Michael J Mastrangelo, Takami Sato
PURPOSE: To compare overall survival in high-risk patients with primary uveal melanoma who received adjuvant sunitinib with institutional controls. DESIGN: Retrospective cohort. PARTICIPANTS: Selection criteria were (1) monosomy 3 and 8q amplification by cytogenetic or DecisionDx-UM Class 2 and (2) monosomy 3 and large tumor size (T3-4 by American Joint Committee on Cancer classification). Exclusion criteria were date of diagnosis before 2007 or after 2013 and age <18 years...
September 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28933276/cyclophosphamide-and-or-anthracyclines-induced-epiphora-in-breast-cancer-patients-a-rare-side-effect
#3
Ruchika Kalra, Bhavesh Chavada, Nishant R Madhani, Bhargav Purohit, C B Tripathi
Two female breast cancer patients developed epiphora after administration of Cyclophosphamide and/or anthracyclines based 2-day chemotherapy regimen. The ophthalmologist was consulted and no apparent cause was found. Both patients was managed by ciprofloxacin eye drops. Chemotherapy-induced ocular complications are not uncommon, but under-reported. Although epiphora is a mild reaction if severe can interfere with daily activities. Patients receiving anticancer drugs should have a thorough ocular evaluation, in order to prevent, early diagnose and efficiently treat established ocular complications of the chemotherapy treatment...
September 19, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28929046/application-of-three-dimensional-printing-for-colon-targeted-drug-delivery-systems
#4
REVIEW
Nitin B Charbe, Paul A McCarron, Majella E Lane, Murtaza M Tambuwala
Orally administered solid dosage forms currently dominate over all other dosage forms and routes of administrations. However, human gastrointestinal tract (GIT) poses a number of obstacles to delivery of the drugs to the site of interest and absorption in the GIT. Pharmaceutical scientists worldwide have been interested in colon drug delivery for several decades, not only for the delivery of the drugs for the treatment of colonic diseases such as ulcerative colitis and colon cancer but also for delivery of therapeutic proteins and peptides for systemic absorption...
April 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/28927532/beyond-mouse-cancer-models-three-dimensional-human-relevant-in-vitro-and-non-mammalian-in-vivo-models-for-photodynamic-therapy
#5
REVIEW
Malgorzata Kucinska, Marek Murias, Patrycja Nowak-Sliwinska
The proper design of experiments is a critical step for each study in order to obtain reproducible and reliable data. Taking into account constant competitiveness in the quickly developing biomedical sciences and the availability of sophisticated techniques, the choice and establishment of an experimental model system are essential for a successful research project. Currently, various sophisticated in vitro and in vivo models are being designed and developed in order to replace the use of mammalian models to investigate the mechanisms of action, activity and properties of novel compounds or treatment modalities...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28924679/psycho-oncology-a-patient-s-view
#6
Patricia Garcia-Prieto
Culturally the most important, valued, and less stigmatized part of cancer care is the medical part: The surgeon cutting the tumors out and the oncologist leading the strategic decision-making of the medical treatments available. The least valued and stigmatized part of cancer remains the psychosocial care. This chapter describes-through the eyes of an academic, psychologist, stage IV melanoma patient, and patient advocate-how one patient navigated changing psycho-oncological needs from early stage-to-stage IV through a whole range of psychological interventions available...
2018: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/28915706/the-role-of-autophagy-in-hepatocellular-carcinoma-friend-or-foe
#7
REVIEW
Lian Liu, Jia-Zhi Liao, Xing-Xing He, Pei-Yuan Li
Autophagy is an evolutionarily conserved lysosome-dependent catabolic process which degrades cell's components in order to recycle substrates to exert optimally and adapt to tough circumstances. It is a critical cellular homeostatic mechanism with stress resistance, immunity, antiaging, and pro-tumor or anti-tumor effects. Among these, the role of autophagy in cancer is the most eye-catching that is not immutable but dynamic and highly complex. Basal autophagy acts as a tumor suppressor by maintaining genomic stability in normal cells...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28912913/paraneoplastic-dermatomyositis-syndrome-presenting-as-dysphagia
#8
Emmanuel Ofori, Daryl Ramai, Mel Ona, Madhavi Reddy
Dermatomyositis (DM) is a rare autoimmune condition which predominantly affects females in the fifth and sixth decades of life. DM presents acutely or progressively as painless proximal skeletal muscle weakness and can be associated with a heliotropic rash around the eyes, and Gottron's papules on extensor surfaces of the hands. While the pathophysiology of DM is still unclear, abnormal T- and B-cell immune activity has been reported. DM has been associated with malignancy and has been shown to appear before, concurrently with, or after diagnosis of cancer...
August 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28911859/recent-development-of-signaling-pathways-inhibitors-of-melanogenesis
#9
REVIEW
Thanigaimalai Pillaiyar, Manoj Manickam, Sang-Hun Jung
Human skin, eye and hair color rely on the production of melanin, depending on its quantity, quality, and distribution, Melanin plays a monumental role in protecting the skin against the harmful effect of ultraviolet radiation and oxidative stress from various environmental pollutants. However, an excessive production of melanin causes serious dermatological problems such as freckles, solar lentigo (age spots), melasma, as well as cancer. Hence, the regulation of melanin production is important for controlling the hyper-pigmentation...
September 12, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28901379/eya2-overexpression-promotes-the-invasion-of-human-astrocytoma-through-the-regulation-of-erk-mmp9-signaling
#10
Zhifeng Wen, Chuansheng Liang, Qichen Pan, Yunjie Wang
The overexpression of eyes absent (Eya) 2 has been found in several human cancers. However, its biological roles and clinical significance in human astrocytoma have not yet been explored. This study investigated the clinical significance and biological roles of Eya2 in human astrocytoma tissues and cell lines. Using immunohistochemistry, we found Eya2 overexpression in 33 out of 90 (36.7%) astrocytoma specimens. The rate of Eya2 overexpression was higher in grade III-IV (48.1%) than in grade Ⅰ+Ⅱ astrocytomas (21...
September 13, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28892622/gold-loaded-nanoporous-ferric-oxide-nanocubes-with-peroxidase-mimicking-activity-for-electrocatalytic-and-colorimetric-detection-of-autoantibody
#11
Mostafa Kamal Masud, Sharda Yadav, Md Nazmul Islam, Nam-Trung Nguyen, Carlos Salomon, Richard Kline, Hatem R Alamri, Zeid Abdullah Alothman, Yusuke Yamauchi, Md Shahriar A Hossain, Muhammad J A Shiddiky
Enzyme-mimicking activity of iron oxide based nanostructures have provided a significant advantage in developing advanced molecular sensors for biomedical and environmental applications. Herein, we introduce the horseradish peroxidase (HRP)-like activity of gold loaded nanoporous ferric oxide nanocubes (Au-NPFe2O3NC) for the development of a molecular sensor with enhanced electrocatalytic and colorimetric (naked-eye) detection of autoantibodies. The results showed that Au-NPFe2O3NC exhibits enhanced peroxidase-like activity towards the catalytic oxidation of 3,3',5,5'-tertamethylbenzidine (TMB) in the presence of H2O2 at room temperature (25°C) and follows the typical Michaelis-Menten kinetics...
September 11, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28886798/enhancing-skin-cancer-diagnosis-with-dermoscopy
#12
REVIEW
Zachary J Wolner, Oriol Yélamos, Konstantinos Liopyris, Tova Rogers, Michael A Marchetti, Ashfaq A Marghoob
Dermoscopy increases the sensitivity for skin cancer detection, decreases the number of benign lesions biopsied for each malignant diagnosis, and enables the diagnosis of thinner melanomas compared with naked eye examination. Multiple meta-analyses have identified that dermoscopy improves the diagnostic accuracy for melanoma when compared with naked eye examination. In addition, studies have established that dermoscopy can aid in the detection of keratinocyte carcinomas. Dermoscopy triage algorithms have been developed to help novices decide when a biopsy or a referral is most appropriate...
October 2017: Dermatologic Clinics
https://www.readbyqxmd.com/read/28871434/cutaneous-and-mucosal-manifestations-of-sj%C3%A3-gren-s-syndrome
#13
REVIEW
Elena Generali, Antonio Costanzo, Carlo Mainetti, Carlo Selmi
Sjögren's syndrome is currently considered an "autoimmune epithelitis," as exocrine glands, especially salivary and lacrimal, are progressively destructed by an immune-mediated process associated with specific serum autoantibodies and local lymphocyte infiltrate. Xerostomia remains a key complain in patients with Sjögren's syndrome but should be evaluated also for other causes such as xerogenic medications, followed by radiation and chemotherapy for head and neck cancers, hormone disorders, infections, or other connective tissue diseases...
September 4, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28868283/uveal-ganglioneuroma-due-to-germline-pten-mutation-cowden-syndrome-presenting-as-unilateral-infantile-glaucoma
#14
Sarah W DeParis, Michele Bloomer, Ying Han, M Reza Vagefi, Joseph T C Shieh, David A Solomon, James Grenert, Alejandra G de Alba Campomanes
PURPOSE: Uveal ganglioneuroma is a rare tumor that usually occurs in association with neurofibromatosis type 1. Here, we present a rare case of a uveal ganglioneuroma leading to a diagnosis of the tumor predisposition condition Cowden syndrome. PROCEDURES: A 5-year-old girl with unilateral refractory glaucoma secondary to diffuse iris and choroidal thickening developed a blind, painful eye. Enucleation was performed, and histopathology revealed infiltration of the entire uveal tract by neoplastic spindle cells containing admixed ganglion cells diagnostic of uveal ganglioneuroma...
July 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/28861359/intraocular-lymphoma
#15
REVIEW
Li-Juan Tang, Chang-Lin Gu, Ping Zhang
Intraocular lymphoma (IOL) is a rare lymphocytic malignancy which contains two main distinct forms. Primary intraocular lymphoma (PIOL) is mainly a sub-type of primary central nervous system lymphoma (PCNSL). Alternatively, IOL can originate from outside the central nervous system (CNS) by metastasizing to the eye. These tumors are known as secondary intraocular lymphoma (SIOL). The IOL can arise in the retina, uvea, vitreous, Bruch's membrane and optic nerve. There are predominantly of B-cell origin; however there are also rare T-cell variants...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28856763/the-fly-eye-through-the-looking-glass
#16
REVIEW
Justin P Kumar
The developing eye-antennal disc of Drosophila melanogaster has been studied for more than a century and it has been used as a model system to study diverse processes such as tissue specification, organ growth, programmed cell death, compartment boundaries, pattern formation, cell fate specification, and planar cell polarity. The findings that have come out of these studies have informed our understanding of basic developmental processes as well as human disease. For example, the isolation of a white-eyed fly ultimately led to a greater appreciation of the role that sex chromosomes play in development, sex determination, and sex linked genetic disorders...
August 30, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28851495/intensity-modulated-radiotherapy-in-head-and-neck-cancer-an-update-for-oral-and-maxillofacial-surgeons
#17
REVIEW
P A Brennan, K L Bradley, M Brands
Intensity-modulated radiation therapy (IMRT), a relatively new method of delivering radiotherapy, can precisely target a point within a specific tumour and reduce the dose to nearby anatomical structures. This is particularly important in the head and neck where radiotherapy can easily and irreparably damage the salivary glands, spinal cord, and eyes, and where, with increasingly better outcomes and survival, late complications of conventional radiotherapy (including osteoradionecrosis of the cervical spine) can be difficult to manage...
August 26, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28844204/ocular-metastasis-from-breast-carcinoma-simulating-anterior-scleritis-a-case-report
#18
Ritesh Kumar Shah, Samir Lamichhane
BACKGROUND: Breast cancer is one of the commonest sources of ocular metastasis. Patients with ocular metastatic disease can present with a variable clinical picture. Patients with a history of breast cancer presenting with any eye symptom should be evaluated with consideration of ocular metastasis. CASE PRESENTATION: We report a case of ocular metastasis in a 46-year-old Brahmin woman presenting with right eye pain. She had been treated for stage IIIc left-sided breast cancer 2 years ago with six cycles of chemotherapy with docetaxel, adriamycin, and cyclophosphamide after undergoing modified radical mastectomy...
August 28, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28844049/pterygia-are-indicators-of-an-increased-risk-of-developing-cutaneous-melanomas
#19
Julie M Crewe, Tim Threlfall, Antony Clark, Paul G Sanfilippo, David A Mackey
AIM: To investigate whether pterygium is an indicator of an increased risk of cutaneous melanoma (CM). METHODS: A matched-cohort study, using linked health administrative data sets to identify all hospital-treated pterygium in Western Australia (WA) between 1979 and 2014. We identified pterygium cases from hospital diagnosis and/or procedure International Classification of Diseases 9th revision (ICD-9) and 10th revision (ICD-10) codes and matched cases by age, sex and residential postcode to WA Electoral Roll controls with no known history of pterygium...
August 26, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28836253/-effect-of-nano-carbon-tattooing-on-the-lesion-localization-in-the-early-colon-cancer-for-additional-surgical-procedure-after-endoscopic-resection
#20
Chen Lin, Zaizhong Zhang, Lie Wang, Nan Lin, Weijin Yang, Weihang Wu, Wen Wang, Rong Wang, Yu Wang
OBJECTIVE: To explore the effect of nano carbon tattooing on the lesion localization in the early colon cancer for additional surgical procedure after endoscopic resection. METHODS: Thirty-five patients with early colon cancer accepted additional surgical procedures after endoscopic resection in Fuzhou General Hospital of PLA from May 2014 to November 2016. All the patients underwent nano carbon tattooing before the end of endoscopic resection: 0.1 ml carbon nanoparticles suspension was respectively injected into the normal intestinal submucosa from 1 cm outside the 4 sites (upper, lower, left and right) of the lesion border by colonoscopy, marking the original lesion location and guiding the subsequent additional surgery...
August 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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