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https://www.readbyqxmd.com/read/28230863/oncogenic-role-of-rab-escort-protein-1-through-egfr-and-stat3-pathway
#1
Un-Jung Yun, Jee Young Sung, Seog-Yun Park, Sang-Kyu Ye, Jaegal Shim, Jae-Seon Lee, Masahiko Hibi, Young-Ki Bae, Yong-Nyun Kim
Rab escort protein-1 (REP1) is linked to choroideremia (CHM), an X-linked degenerative disorder caused by mutations of the gene encoding REP1 (CHM). REP1 mutant zebrafish showed excessive cell death throughout the body, including the eyes, indicating that REP1 is critical for cell survival, a hallmark of cancer. In the present study, we found that REP1 is overexpressed in human tumor tissues from cervical, lung, and colorectal cancer patients, whereas it is expressed at relatively low levels in the normal tissue counterparts...
February 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28229253/the-biology-of-uveal-melanoma
#2
Adriana Amaro, Rosaria Gangemi, Francesca Piaggio, Giovanna Angelini, Gaia Barisione, Silvano Ferrini, Ulrich Pfeffer
Uveal melanoma (UM), a rare cancer of the eye, is distinct from cutaneous melanoma by its etiology, the mutation frequency and profile, and its clinical behavior including resistance to targeted therapy and immune checkpoint blockers. Primary disease is efficiently controlled by surgery or radiation therapy, but about half of UMs develop distant metastasis mostly to the liver. Survival of patients with metastasis is below 1 year and has not improved in decades. Recent years have brought a deep understanding of UM biology characterized by initiating mutations in the G proteins GNAQ and GNA11...
February 22, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28224562/solitary-choroidal-metastasis-from-gastric-adenocarcinoma-a-case-report
#3
Masanari Shimada, Susumu Amaya, Hiroaki Sugita, Yuichiro Furutani, Yoshinori Munemoto, Takeshi Mitsui, Toshiro Tanahashi, Yuzo Kikuchi
BACKGROUND: Metastatic choroidal carcinomas that originated from the gastrointestinal tract are extremely rare. We report a case of suspected solitary choroidal metastasis from gastric adenocarcinoma. CASE PRESENTATION: The patient was a 60-year-old man who had undergone laparoscopic distal gastrectomy with D1+ lymphadenecetomy for gastric cancer. The clinical stage was T1bN0M0 (TNM classification), but the pathological stage was T4aN0M0 beyond expectation. Adjuvant chemotherapy with oral Tegafur, Gimeracil, Oteracil potassium (TS-1(®)) was initiated...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28221296/long-term-outcomes-of-eye-sparing-surgery-for-adenoid-cystic-carcinoma-of-lacrimal-gland
#4
Jisang Han, Yoon-Duck Kim, Kyung In Woo, Deepak Sobti
PURPOSE: This study's primary purpose is to assess the long-term outcomes of patients who have undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland. METHODS: In this retrospective analysis, clinical records were reviewed of all patients diagnosed with adenoid cystic carcinoma of the lacrimal gland, at a single institution, between March 1998 and November 2012. Ten patients were identified as having undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland...
February 17, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28219351/positive-bacterial-culture-in-conjunctival-sac-before-cataract-surgery-with-night-stay-is-related-to-diabetes-mellitus
#5
Tetsuhiro Kawata, Toshihiko Matsuo
BACKGROUND: The aim of this study is to elucidate background clinical factors in patients with positive bacterial culture for the conjunctival sac before cataract surgery in Japan. METHODS: Retrospective review was made on medical records of 576 consecutive patients who underwent conjunctival sac culture before cataract surgery with night stay at a hospital in 2 years from January 2013 to December 2014. In the patients with sequential bilateral surgeries, the data were chosen for bacterial culture in the eye which had earlier surgery...
February 20, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28215809/topological-data-analysis-tda-applied-to-reveal-pedogenetic-principles-of-european-topsoil-system
#6
Aleksandar Savic, Gergely Toth, Ludovic Duponchel
Recent developments in applied mathematics are bringing new tools that are capable to synthesize knowledge in various disciplines, and help in finding hidden relationships between variables. One such technique is topological data analysis (TDA), a fusion of classical exploration techniques such as principal component analysis (PCA), and a topological point of view applied to clustering of results. Various phenomena have already received new interpretations thanks to TDA, from the proper choice of sport teams to cancer treatments...
February 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28213097/self-assembled-tumor-targeting-hyaluronic-acid-nanoparticles-for-photothermal-ablation-in-orthotopic-bladder-cancer
#7
Tingsheng Lin, Ahu Yuan, Xiaozhi Zhao, Huibo Lian, Junlong Zhuang, Wei Chen, Qing Zhang, Guangxiang Liu, Shiwei Zhang, Wei Chen, Wenmin Cao, Chengwei Zhang, Jinhui Wu, Yiqiao Hu, Hongqian Guo
: Bladder cancer is one of the most frequent malignancies in the urinary system. Radical cystectomy is inevitable when bladder cancer progresses to a muscle-invasive disease. However, cystectomy still causes a high risk of death and a low quality of life (such as ureter-abdomen ostomy, uroclepsia for ileal-colon neobladder). Therefore, more effective treatments as well as bladder preservation are needed. We developed self-assembled tumor-targeting hyaluronic acid-IR-780 nanoparticles for photothermal ablation in over-expressing CD44 (the receptor for HA) bladder cancer, which show high tumor selectivity, high treatment efficacy, good bioavailability, and excellent biocompatibility...
February 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28209503/lymphoma-of-the-eyelid-an-international-multicenter-retrospective-study
#8
Frederik Holm Svendsen, Peter Kristian Rasmussen, Sarah E Coupland, Bita Esmaeli, Paul T Finger, Gerardo F Graue, Hans E Grossniklaus, Santosh G Honavar, Jwu Jin Khong, Penelope A McKelvie, Kaustubh Mulay, Elisabeth Ralfkiaer, Lene Dissing Sjö, Geeta K Vemuganti, Bradley A Thuro, Jeremy Curtin, Steffen Heegaard
PURPOSE: To document subtype-specific clinical features of lymphoma of the eyelid, and their effect on patient outcome. DESIGN: Retrospective observational case series. METHODS: Patient data were collected from 7 international eye cancer centers from January 1st 1980 through December 31st 2015. The cases included primary and secondary lymphomas affecting the eyelid. Overall survival, disease-specific survival (DSS), and progression-free survival were the primary end points...
February 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28205307/segmentation-of-organs-at-risks-in-head-and-neck-ct-images-using-convolutional-neural-networks
#9
Bulat Ibragimov, Lei Xing
PURPOSE: Accurate segmentation of organs-at-risks (OARs) is the key step for efficient planning of radiation therapy for head and neck (HaN) cancer treatment. In the work, we proposed the first deep learning-based algorithm, for segmentation of OARs in HaN CT images, and compared its performance against state-of-the-art automated segmentation algorithms, commercial software, and interobserver variability. METHODS: Convolutional neural networks (CNNs)-a concept from the field of deep learning-were used to study consistent intensity patterns of OARs from training CT images and to segment the OAR in a previously unseen test CT image...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28203192/docetaxel-retinopathy-a-case-report
#10
Sylvia Nghiem-Buffet, Salomon Yves Cohen, Audrey Giocanti-Auregan
BACKGROUND: To report the use of En-face optical coherence tomography (OCT) in a patient treated with docetaxel and tamoxifen for breast cancer for the detection of macular edema (ME) without evidence of leakage on fluorescein angiography (FA). CASE PRESENTATION: A 52-year-old woman treated for breast cancer presented with bilateral visual loss for 2 months. FA showed no significant leakage while spectral-domain OCT scans of both eyes showed foveolar and parafoveolar cystic spaces in a moderately thickened macula...
January 2017: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/28181367/periocular-breast-carcinoma-metastases-correlation-of-clinical-radiologic-and-histopathologic-features
#11
Natalie Homer, Frederick A Jakobiec, Anna Stagner, Mary Elizabeth Cunnane, Suzanne K Freitag, Aaron Fay, Michael K Yoon
IMPORTANCE: To describe presenting patterns of breast cancer metastases to the orbit and eyelids BACKGROUND: To provide clinical, radiographic, and pathologic correlations of breast metastases to the orbit or eyelids and evaluate radiographic volumetric orbital changes DESIGN: Retrospective review in an academic center PARTICIPANTS: Ten female patients with periocular metastatic breast carcinoma who were seen at the Massachusetts Eye and Ear Infirmary Oculoplastics Clinic METHODS: Retrospective review of patient records, imaging and pathology findings...
February 9, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28176669/effects-of-carotenoids-on-health-are-all-the-same-results-from-clinical-trials
#12
Arrigo F G Cicero, Alessandro Colletti
BACKGROUND: Oxidative stress is implicated in the pathogenesis of a lot of age-related pathologies and some types of cancers. Carotenoids have shown antioxidant properties, due to the ability to quench singlet oxygen and to scavenge free radicals that may prevent and treat a wide range of chronic diseases. The aim of this review is to discuss the clinical evidence present in literature about the effects of carotenoids on human health and to evaluate their effectiveness in the prevention and treatment of many chronic diseases...
February 6, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28167415/a-visible-and-colorimetric-aptasensor-based-on-dna-capped-single-walled-carbon-nanotubes-for-detection-of-exosomes
#13
Yaokun Xia, Mengmeng Liu, Liangliang Wang, An Yan, Wenhui He, Mei Chen, Jianming Lan, Jiaoxing Xu, Lunhui Guan, Jinghua Chen
Recently, many studies have shown the potential use of circulating exosomes as novel biomarkers for monitoring and predicting a number of complex diseases, including cancer. However, reliable and cost-effective detection of exosomes in routine clinical settings, still remain a difficult task, mainly due to the lack of adequately easy and fast assay platforms. Therefore, we demonstrate here the development of a visible and simple method for the detection of exosomes by integrating single-walled carbon nanotubes that being excellent water solubility (s-SWCNTs) and aptamer...
January 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28165837/endoscopic-dacryocystorhinostomy-following-head-and-neck-radiation-therapy
#14
Adam R Sweeney, Greg E Davis, Shu-Hong Chang, Arash Jian-Amadi
This article determines the efficacy of endoscopic dacryocystorhinostomy (endoDCR) in patients who have undergone adjuvant external beam radiation therapy (XRT) following head and neck cancer resection. A retrospective chart review was performed on all patients who underwent endoDCR between 2006 and 2014 at a tertiary referral center. Cases were reviewed and selected for the following inclusion criteria: history of adjuvant sinonasal XRT following head and neck cancer resection, preoperative probing and irrigation demonstrating nasolacrimal duct obstruction (NLDO), postoperative probing and irrigation following silicone tube extubation...
February 6, 2017: Orbit
https://www.readbyqxmd.com/read/28156544/equity-in-patient-provider-communication-regarding-treatment-related-symptoms-and-health-related-quality-of-life-hrqol-among-breast-cancer-survivors
#15
Jennifer Schaal, Linda Robertson, Eugenia Eng, Jemeia G Kollie, Christina Yongue, Karen Foley, Beth Smith, Mellissa K Yee, Kristin Black, Katrina Ellis, Lucretia Hoffman, Alexandra Lightfoot, Claire Morse, Neda Padilla, Sam Cykert
: 127 Background: Compared with white breast cancer patients, black patients more often report inadequate symptom control and decrements in health-related quality of life (HRQOL). Racial differences in patient-provider communication (PPC) are well-documented and linked to worse health outcomes for minorities; however, less is known about inequities in symptom and HRQOL discussions among cancer patients and providers. As part of an NCI-funded systems change intervention to improve racial equity in treatment completion among Black and White cancer patients, we assessed racial differences in PPC regarding treatment-related symptoms, HRQOL issues (e...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156467/association-between-tobacco-use-pain-expression-and-maladaptive-coping-among-patients-with-advanced-cancer
#16
Yu Jung Kim, Akhila Sunkepally Reddy, David Hui, Kimberson Cochien Tanco, Diane D Liu, Minjeong Park, Janet L Williams, Cindy L Carmack, Eduardo Bruera
: 65 Background: Cancer patients who smoke have been reported to have higher pain expression and increased risk for opioid abuse. The purpose of our study is to evaluate the association between tobacco use, symptom expression, and maladaptive coping in advanced cancer patients. METHODS: We prospectively enrolled advanced cancer patients evaluated in an outpatient Supportive Care Center and collected data on patient demographics, cancer diagnosis, morphine equivalent daily dose (MEDD), cigarette smoking status using Behavioral Risk Factor Surveillance System, symptom expression as measured by Edmonton Symptom Assessment Scale, Cut down/Annoyed/Guilty/Eye opener (CAGE alcoholism questionnaire), short form Screener and Opioid Assessment for Patients with Pain (SOAP-SF) survey, and Brief COPE Questionnaire...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28150210/an-ultrasensitive-biosensing-platform-employing-acetylcholinesterase-and-gold-nanoparticles
#17
Dingbin Liu, Xiaoyuan Chen
Enzyme-linked immunosorbent assay (ELISA) is a well-known strategy for biomarker detection with a color change, which can be seen by the naked eyes. However, the moderate sensitivity of conventional ELISA limits its applications in many cases where the concentrations of biomarker are very low, such as cancer diagnosis. Here we describe an ultrasensitive colorimetric assay based on acetylcholinesterase (AChE)-catalyzed hydrolysis reaction, whose products trigger the aggregation of gold nanoparticles (AuNPs), causing a distinct color change of the solution from red to purple...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28149156/patient-radiation-biological-risk-in-computed-tomography-angiography-procedure
#18
M Alkhorayef, E Babikir, A Alrushoud, H Al-Mohammed, A Sulieman
Computed tomography angiography (CTA) has become the most valuable imaging modality for the diagnosis of blood vessel diseases; however, patients are exposed to high radiation doses and the probability of cancer and other biological effects is increased. The objectives of this study were to measure the patient radiation dose during a CTA procedure and to estimate the radiation dose and biological effects. The study was conducted in two radiology departments equipped with 64-slice CT machines (Aquilion) calibrated according to international protocols...
February 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28146039/a-rare-ocular-presentation-of-metastatic-lung-cancer-unilateral-anterior-chamber-angle-bilateral-choroidal-and-multiple-intracranial-metastases
#19
Amber Hoang, Kay T Khine, O'Rese J Knight, Rachel A Tesser, David A Chesnutt
A 64-year-old man who presented with photopsia was found to have elevated intraocular pressure in one eye and optic disc swelling in the other eye. He was initially diagnosed with neurocysticercosis and later metastatic lung adenocarcinoma. The purpose of this paper is to report a rare case of bilateral glare as the first sign of diffusely metastatic cancer and to raise clinical suspicion for systemic malignancy in the presence of multiple ocular manifestations.
February 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28133189/-eye-disorders-associated-with-s-1-chemotherapy-in-gastric-cancer-patients
#20
Chika Fujii, Yutaka Kimura, Yoichi Makari, Jota Mikami, Junya Fujita, Shunji Kamigaki, Hitoshi Hayashi, Yukiko Yanagishita, Yukako Yasui, Toshihiko Ishizaka
Eye disorders are one of the characteristic adverse events associated with S-1 chemotherapy. In this retrospective study, we investigated the frequency and outcome of eye disorders associated with S-1 chemotherapy in gastric cancer patients. This retrospective study included 75 advanced gastric cancer patients who received S-1 monotherapy between January 2014 and December 2015. We retrospectively evaluated the frequency, Grade, and treatment of eye disorders. Eye disorders were observed in 16 patients(21%)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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