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https://www.readbyqxmd.com/read/28934731/fasting-spot-urine-ph-is-associated-with-metabolic-syndrome-in-the-japanese-population
#1
Masanori Shimodaira, Shinji Okaniwa, Tomohiro Nakayama
OBJECTIVE: To investigate the relationship between urine pH and metabolic syndrome (MetS) and its components while controlling for covariates. SUBJECTS AND METHODS: This cross-sectional study was conducted on 5,430 Japanese subjects (4691 without MetS; 739 with MetS) undergoing health assessments. Partial correlation analysis and analysis of covariance were used for controlling confounding parameters (age, gender, serum uric acid (UA) levels, high sensitivity C-reactive protein, estimated glomerular filtration rate, and smoking and drinking statuses)...
September 19, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28934718/urinary-bpa-and-phthalate-metabolite-concentrations-and-plasma-vitamin-d-levels-in-pregnant-women-a-repeated-measures-analysis
#2
Lauren E Johns, Kelly K Ferguson, David E Cantonwine, Thomas F McElrath, Bhramar Mukherjee, John D Meeker
BACKGROUND: In addition to its well-established role in maintaining skeletal health, vitamin D has essential regulatory functions in female reproductive and pregnancy outcomes. Phthalates and bisphenol A (BPA) are endocrine disruptors, and previous research has suggested that these chemical agents may disrupt circulating levels of total 25(OH)D in adults. OBJECTIVES: We investigated the relationships between repeated measures of urinary phthalate metabolites and BPA and circulating total 25(OH)D in a prospective cohort of pregnant women...
August 31, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934031/simultaneous-detection-of-15-antibiotic-growth-promoters-in-bovine-muscle%C3%AF-blood-and-urine-by-uplc-ms-ms
#3
Zhi Wang, Zongwei Shi, Cunxian Xi, Guomin Wang, Shurui Cao, Lei Zhang, Bobin Tang, Zhaode Mu
An analytical method was established for the rapid detection of antibiotic growth promoters (AGPs) in bovine muscle, and bovine blood and bovine urine, using ultra high performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). After the addition of an aqueous solution of EDTA-Na2, the pH of bovine urine samples was directly adjusted to 5.2 by acetic acid-ammonium acetate and purified by HLB solid-phase extraction cartridge; bovine muscle and bovine blood samples processing were extracted with acetonitrile (ACN) and ACN-water (90:10; v/v) without any purification step...
September 21, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28933159/hemoglobin-adducts-and-urinary-metabolites-of-arylamines-and-nitroarenes
#4
Gabriele Sabbioni
Arylamines and nitroarenes are intermediates in the production of pharmaceuticals, dyes, pesticides, and plastics and are important environmental and occupational pollutants. N-Hydroxyarylamines are the toxic common intermediates of arylamines and nitroarenes. N-Hydroxyarylamines and their derivatives can form adducts with hemoglobin (Hb-adducts), albumin, DNA, and tissue proteins in a dose-dependent manner. Most of the arylamine Hb-adducts are labile and undergo hydrolysis in vitro, by mild acid or base, to form the arylamines...
September 21, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28932928/a-phase-i-study-to-assess-the-mass-balance-excretion-and-pharmacokinetics-of-14-c-ixazomib-an-oral-proteasome-inhibitor-in-patients-with-advanced-solid-tumors
#5
Neeraj Gupta, Steven Zhang, Sandeepraj Pusalkar, Mihaela Plesescu, Swapan Chowdhury, Michael J Hanley, Bingxia Wang, Cindy Xia, Xiaoquan Zhang, Karthik Venkatakrishnan, Dale R Shepard
This two-part, phase I study evaluated the mass balance, excretion, pharmacokinetics (PK), and safety of ixazomib in patients with advanced solid tumors. In Part A of the study, patients received a single 4.1 mg oral solution dose of [(14)C]-ixazomib containing ~500 nCi total radioactivity (TRA), followed by non-radiolabeled ixazomib (4 mg capsule) on days 14 and 21 of the 35-day PK cycle. Patients were confined to the clinic for the first 168 h post dose and returned for 24 h overnight clinic visits on days 14, 21, 28, and 35...
September 21, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28932401/practical-approach-to-detection-and-management-of-acute-kidney-injury-in-critically-ill-patient
#6
REVIEW
Vahid Mohsenin
BACKGROUND: Acute kidney injury (AKI) is a common complication in critically ill patients and is associated with high morbidity and mortality. This paper provides a critical review of the etiologies of AKI and a systematic approach toward its diagnosis and management with emphasis on fluid volume assessment and the use of urine biochemical profile and microscopy in identifying the nature and the site of kidney injury. MATERIALS AND METHODS: The search of PubMed and selection of papers had employed observational designs or randomized control trials relevant to AKI...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28932363/cadmium-toxicity-and-treatment-an-update
#7
REVIEW
Mehrdad Rafati Rahimzadeh, Mehravar Rafati Rahimzadeh, Sohrab Kazemi, Ali-Akbar Moghadamnia
Cadmium poisoning has been reported from many parts of the world. It is one of the global health problems that affect many organs and in some cases it can cause deaths annually. Long-term exposure to cadmium through air, water, soil, and food leads to cancer and organ system toxicity such as skeletal, urinary, reproductive, cardiovascular, central and peripheral nervous, and respiratory systems. Cadmium levels can be measured in the blood, urine, hair, nail and saliva samples. Patients with cadmium toxicity need gastrointestinal tract irrigation, supportive care, and chemical decontamination traditional-based chelation therapy with appropriate new chelating agents and nanoparticle-based antidotes...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28932301/melatonin-level-variations-with-different-behavioural-risk-factors-in-obese-female-patients
#8
Ana Malazonia, Tamar Zerekidze, Elen Giorgadze, Natia Chkheidze, Ketevan Asatiani
AIM: The role of behavioural factors and sleep duration and quality is important in the pathogenesis of obesity. The aim of our study was to evaluate the effects of behavioural risk factors on melatonin secretion in women. SUBJECTS AND METHODS: In total, 120 female patients were enrolled in the study and divided into two groups according to the body mass index. Detailed history, anthropometric measurements, urine and blood samples were evaluated for each patient...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28932120/natural-reduced-water-suppressed-anxiety-and-protected-the-heightened-oxidative-stress-in-rats
#9
Koji Masuda, Yoshihiro Tanaka, Masayuki Kanehisa, Taiga Ninomiya, Ayako Inoue, Haruka Higuma, Chiwa Kawashima, Mari Nakanishi, Kana Okamoto, Jotaro Akiyoshi
BACKGROUND: In Japan, the effects of reduced water, such as hydrogen-rich electrolyzed reduced water and natural reduced water, like Hita Tenryosui water(®), have been examined. The purpose of the present study was to identify the role of natural reduced water in anxiety and blood biochemical analysis. MATERIALS AND METHODS: Natural reduced water and distilled water were administered to rats for 180 consecutive days, and their effect on anxiety-like behavior and depression was examined by using elevated plus maze, light/dark, forced swimming, and conditioned fear tests...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28931470/free-light-chains-eclectic-multipurpose-biomarker
#10
REVIEW
Umberto Basile, Francesca Gulli, Laura Gragnani, Cecilia Napodano, Krizia Pocino, Gian Ludovico Rapaccini, Michele Mussap, Anna Linda Zignego
The production of antibodies is accompanied by a slight excess of synthesis of κ and λ immunoglobulin light chains; small amounts of them are released in the peripheral blood and can also be found in various body fluids, such as synovial fluid, cerebrospinal fluid, urine and saliva. They are rapidly filtered by the glomerulus and >99% are reabsorbed from the cells of the proximal convoluted tubule, making them present in the urine in only trace amounts. The production of an excess of protein without a reason or a specific function in a biological system is rare...
September 17, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28930879/repeat-effort-performance-is-reduced-24-h-following-acute-dehydration-in-mixed-martial-arts-athletes
#11
Oliver R Barley, Fiona Iredale, Dale W Chapman, Amanda Hopper, Chris Abbiss
This study sought to determine the influence of acute dehydration on physical performance and physiology in Mixed Martial Arts (MMA). MMA athletes (n=14; age: 23±4 years), completed in a randomised counterbalanced order a dehydration protocol, (DHY: 3 h cycling at 60 W in 40°C to induce 5% dehydration) or thermoneutral control (25°C: CONT) exercise, followed by ad libitum fluid/food intake. Performance testing (a repeat sled push test, medicine ball chest throw and vertical jump) was completed 3 and 24 h following the intervention, while urine and blood samples were collected before, 20 min, 3 and 24 h following the intervention...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930715/cigarette-smoking-attenuates-kidney-protection-by-angiotensin-converting-enzyme-inhibition-in-nondiabetic-chronic-kidney-disease
#12
Bethany Roehm, Jan Simoni, Jessica Pruszynski, Donald E Wesson
BACKGROUND: Cigarette smoking exacerbates the estimated glomerular filtration rate (eGFR) decline in nondiabetic chronic kidney disease (CKD) despite the kidney protection that is achieved by angiotensin converting enzyme inhibition (ACEI). Whether smoking cessation restores ACEI-related kidney protection is not known. METHODS: This 5-year, prospective, prevention trial recruited 108 smokers and 108 nonsmokers with stage-2 nondiabetic CKD with primary hypertension and urine albumin-to-creatinine ratio (Ualb) >200 mg/g...
September 21, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28929299/the-t-plasty-as-therapy-for-recurrent-bladder-neck-stenosis-success-rate-functional-outcome-and-patient-satisfaction
#13
Clemens M Rosenbaum, Roland Dahlem, Valentin Maurer, Luis A Kluth, Malte W Vetterlein, Margit Fisch, Victor Schuettfort, C Philip Reiss
PURPOSE: To determine success rate (SR), functional outcome, and patient satisfaction of a modified YV-plasty for reconstruction of the bladder neck in case of recurrent bladder neck stenosis (BNS) after transurethral surgery of the prostate: the T-plasty. PATIENTS AND METHODS: We identified all patients who underwent T-plasty at our center between December 2008 and July 2016. Patients' charts were reviewed. Patients were queried by telephone and by mail at time of follow-up (FU)...
September 19, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28929116/the-diagnostic-value-of-nuclear-matrix-proteins-in-bladder-cancer-in-the-aspect-of-environmental-risk-from-carcinogens
#14
Beata Szymańska, Ewa Sawicka, Anna Guzik, Romuald Zdrojowy, Anna Długosz
BACKGROUND: The interaction of environmental factors with genetic susceptibility and detoxification level seems to be an important causative factor in bladder cancer (BC). The aim of this study was to look for a BC marker panel which reflects the environmental risk. The nuclear matrix protein 22 (NMP22), bladder cancer-4 (BLCA-4), and total level proteins NMP22 and BLCA-4 (NMBL) in BC patients with genetic predisposition NAT2 (classified as slow acetylators, SA), DNA damage (8-OHdG), and detoxification by isoenzyme GSTπ activity were measured...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28929104/increased-serum-and-urinary-oxytocin-concentrations-after-nasal-administration-in-beagle-dogs
#15
Andrea Temesi, Julianna Thuróczy, Lajos Balogh, Ádám Miklósi
In recent years more and more studies have revealed the effect of extraneous oxytocin on the social behavior of dogs. The distribution of administered oxytocin in different physiologically relevant compartments is important because this knowledge forms the basis for the timing of behavior tests after the administration. Most behavioral studies rely on the non-invasive intranasal application of oxytocin. The aim of this study was to determine the time course of intranasal administered oxytocin secretion into blood and urine and also establish a connection between intranasal received oxytocin and urinary cortisol in dogs...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28928059/garlic-extract-increases-non-clipped-kidney-tubular-natriuresis-and-diuresis-in-the-2-kidney-1-clip-rat-model-significance-in-hypertension
#16
Khaled K Al-Qattan, Martha Thomson, Muslim Ali
BACKGROUND: Angiotensin II (AngII) is a potent modulator of vascular tone and renal clearance function. Raw garlic aqueous extract (RGAE) inhibits angiotensin I converting enzyme (ACE) dipeptidase activity and therefore AngII generation in the 2-kidney, 1-clip rat model (2K-1Cr). OBJECTIVE: This study investigated the effect of RGAE on the non-clipped kidney clearance function and blood pressure (BP) in the 2 K-1Cr. METHOD: 2K-1Cr were anesthetized, cannulated and instrumentalized and the acute effect during the first hour post-administration of a single intravenous dose of RGAE (30mg/100gb...
September 12, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28927454/extended-spectrum-beta-lactamase-and-metallo-beta-lactamase-production-among-escherichia-coli-and-klebsiella-pneumoniae-isolated-from-different-clinical-samples-in-a-tertiary-care-hospital-in-kathmandu-nepal
#17
Krishus Nepal, Narayan Dutt Pant, Bibhusan Neupane, Ankit Belbase, Rikesh Baidhya, Ram Krishna Shrestha, Binod Lekhak, Dwij Raj Bhatta, Bharat Jha
BACKGROUND: Extended spectrum beta-lactamase (ESBL) and metallo beta-lactamase (MBL) production in Klebsiella pneumoniae and Escherichia coli are the commonest modes of drug resistance among these commonly isolated bacteria from clinical specimens. So the main purpose of our study was to determine the burden of ESBL and MBL production in E. coli and K. pneumoniae isolated from clinical samples. Further, the antimicrobial susceptibility patterns of E. coli and K. pneumoniae were also determined...
September 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28927277/benchmark-dose-modeling-estimates-of-the-concentrations-of-inorganic-arsenic-that-induce-changes-to-the-neonatal-transcriptome-proteome-and-epigenome-in-a-pregnancy-cohort
#18
Julia Rager, Scott S Auerbach, Grace A Chappell, Elizabeth Martin, Chad Thompson, Rebecca C Fry
Prenatal inorganic arsenic (iAs) exposure influences the expression of critical genes and proteins associated with adverse outcomes in newborns, in part through epigenetic mediators. The doses at which these genomic and epigenomic changes occur have yet to be evaluated in the context of dose-response modeling. The goal of the present study was to estimate iAs doses that correspond to changes in transcriptomic, proteomic, epigenomic, and integrated multi-omic signatures in human cord blood through benchmark dose (BMD) modeling...
September 19, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28927237/augmented-association-between-blood-pressure-and-proteinuria-in-hyperuricemic-patients-with-non-nephrotic-chronic-kidney-disease
#19
K Kohagura, M Kochi, T Miyagi, R Zamami, K Nagahama, K Yonemoto, Y Ohya
Background: Hyperuricemia (HU) may enhance susceptibility to hypertensive renal damage via disrupted autoregulation of glomerular hemodynamics. The effect of HU on the association between blood pressure (BP) and proteinuria remains unknown in patients with chronic kidney disease (CKD). Methods: In total, 109 patients with non-nephrotic CKD (55 men and 54 females) who underwent renal biopsy were recruited. Arteriolar hyalinosis was semiquantitatively assessed via arteriole grading...
September 13, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28925888/a-self-nanoemulsifying-drug-delivery-system-for-poorly-water-soluble-tolbutamide-development-optimization-and-pharmacodynamic-studies
#20
Deepti Pandita, Neelam Kumari, Viney Lather
The current investigation involves the development of a thermodynamically stable and dilutable self-nanoemulsifying drug delivery system (SNEDDS) for tolbutamide, a poorly water soluble hypoglycemic drug, in order to achieve higher water solubility and enhanced dissolution rate which in turn improves its oral bioavailability. Pseudo-ternary phase diagrams suggested the suitability of oleic acid (lipid), Tween 20 (surfactant) and PEG 400 (co-surfactant) for developing the SNEEDS formulations. The optimal SNEDDS formulation having mean globule diameter, viscosity, polydispersity value of 58...
September 15, 2017: Pharmaceutical Nanotechnology
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