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https://www.readbyqxmd.com/read/28916103/controlled-synchronized-actuation-of-microdroplets-by-gravity-in-a-superhydrophobic-3d-printed-device
#1
P E Oomen, J P S H Mulder, E Verpoorte, R D Oleschuk
Droplet manipulation over open surfaces allows one to perform assays with a large degree of control and high throughput, making them appealing for applications in drug screening or (bio)analysis. However, the design, manufacturing and operation of these systems comes with high technical requirements. In this study we employ a commercial, low-friction, superhydrophobic coating, Ultra-Ever Dry(®), on a 3D-printed microfluidic device. The device features individual droplet compartments, which allow the manipulation of discrete droplets (10-50 μL) actuated by gravity alone...
October 2, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28911684/a-randomized-double-blind-clinical-study-to-determine-the-effect-of-ankascin-568-plus-on-blood-glucose-regulation
#2
Yin-Ruei Wang, Sheng-Fu Liu, You-Cheng Shen, Chien-Li Chen, Chine-Ning Huang, Tzu-Ming Pan, Chin-Kun Wang
Diabetes is the fourth major cause of death in Taiwan. High blood glucose can lead to macrovascular diseases, small vessel diseases (retinopathy, kidney disease), and neuropathy. This study aimed to investigate whether Monascus-fermented products (ANKASCIN 568 plus) can regulate blood glucose and blood lipids. This study enrolled 39 patients with a fasting blood glucose level between 100 mg/dL and 180 mg/dL, and a glycated hemoglobin (HbA1c) level of <9%. All patients were randomly divided into placebo (n=20) and experimental (n=19) groups...
April 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28875002/prevalence-of-g6pd-deficiency-in-children-with-hepatitis-a
#3
Ghasem Miri-Aliabad, Ali Khajeh, Tooran Shahraki
Introduction: Hepatitis A virus is the most prevalent viral hepatitis. It is globally a major public health problem with different clinical symptoms. This study aimed at investigating the clinical findings and prevalence of glucose 6-phosphate dehydrogenase (G6PD) deficiency in children with hepatitis A. Materials and Methods: In this prospective study, demographical information, clinical findings, and G6PD level of hepatitis A patients, who were visited at Pediatric Hematology clinic, were entered into the database...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28868127/mori-cortex-prevents-kidney-damage-through-inhibiting-expression-of-inflammatory-factors-in-the-glomerulus-in-streptozocin-induced-diabetic-rats
#4
Lili Ma, Hailai Ni, Xinrong Zou, Yanyan Yuan, Chun Luo, Bingyang Liu, Fuyan Wang, Yang Xi, Yudong Chu, Pangjie Xu, Xiaohui Qiu, Song Li, Shizhong Bu
OBJECTIVES: It has been widely reported that Mori cortex extract (MCE) is used for the treatment of diabetes mellitus in traditional medicine. The present study was designed to investigate its mechanism of action in the treatment of diabetic nephropathy (DN). We assessed whether MCE preventive treatment ameliorates kidney damage in high-fat diet and streptozotocin (STZ)-induced type 2 diabetic rats. MATERIALS AND METHODS: Rats were fed a high-fat diet and injected with STZ...
June 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28861867/urine-glucose-levels-are-disordered-before-blood-glucose-level-increase-was-observed-in-zucker-diabetic-fatty-rats
#5
Wei Yin, Weiwei Qin, Youhe Gao
Many patients with diabetes are not diagnosed at all or are diagnosed too late to be effectively treated, resulting in nonspecific symptoms and a long period of incubation of the disease. Pre-diabetes is an early warning signal of diabetes, and the change of urine glucose in this period has been ignored even though urine has long been related with diabetes. In this study, Zucker diabetic fatty (ZDF) rats were used to test if there were changes in urine glucose before blood glucose increases. Six 8-week-old male ZDF rats (fa/fa) and Zucker lean (ZL) rats (fa/+) were fed with Purina 5008 high-fat diet and tested for fasting blood glucose and urine glucose...
August 29, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28855892/albuminuria-reduction-after-high-dose-of-vitamin-d-in-patients-with-type-1-diabetes-mellitus-a-pilot-study
#6
João Soares Felício, Alana Ferreira de Oliveira, Amanda Soares Peixoto, Ana Carolina Contente Braga de Souza, João Felício Abrahão Neto, Franciane Trindade Cunha de Melo, Carolina Tavares Carvalho, Manuela Nascimento de Lemos, Sávio Diego Nascimento Cavalcante, Fabricio de Souza Resende, Márcia Costa Dos Santos, Ana Regina Motta, Luísa Corrêa Janaú, Elizabeth Sumi Yamada, Karem Miléo Felício
BACKGROUND: Some studies suggest an association between diabetic kidney disease (DKD) and vitamin D (VD), but there is no data about the effect of high dose of VD on DKD in type 1 diabetes mellitus (T1DM). Our pilot study aims to evaluate albuminuria reduction in patients with T1DM supplemented with high dose of VD. METHODS: 22 patients received doses of 4,000 and 10,000 IU/day of cholecalciferol for 12 weeks according to patient's previous VD levels. They were submitted to continuous glucose monitoring system, 24 hours ambulatory blood pressure monitoring and urine albumin-to-creatinine ratio before and after VD supplementation...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28840540/a-more-tubulocentric-view-of-diabetic-kidney-disease
#7
REVIEW
Letizia Zeni, Anthony G W Norden, Giovanni Cancarini, Robert J Unwin
Diabetic nephropathy (DN) is a common complication of Diabetes Mellitus (DM) Types 1 and 2, and prevention of end stage renal disease (ESRD) remains a major challenge. Despite its high prevalence, the pathogenesis of DN is still controversial. Initial glomerular disease manifested by hyperfiltration and loss of glomerular size and charge permselectivity may initiate a cascade of injuries, including tubulo-interstitial disease. Clinically, 'microalbuminuria' is still accepted as an early biomarker of glomerular damage, despite mounting evidence that its predictive value for DN is questionable, and findings that suggest the proximal tubule is an important link in the development of DN...
August 24, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28836175/canagliflozin-a-review-in-type-2-diabetes
#8
Emma D Deeks, André J Scheen
Canagliflozin (Invokana(®)) is a sodium-glucose co-transporter-2 (SGLT2) inhibitor indicated in various countries worldwide for the once-daily oral treatment of type 2 diabetes (T2D). Canagliflozin lowers blood glucose levels independently of insulin, with the inhibition of SGLT2 reducing renal reabsorption of glucose and increasing excretion of glucose in the urine. In well-designed clinical trials, canagliflozin (as first-line monotherapy or add-on therapy to other antihyperglycaemic agents) improved glycaemic control in adults with T2D, including those of older age and/or at high cardiovascular (CV) risk, and also had beneficial effects on their bodyweight and blood pressure (BP)...
August 23, 2017: Drugs
https://www.readbyqxmd.com/read/28833382/bayesian-hierarchical-joint-modeling-of-repeatedly-measured-continuous-and-ordinal-markers-of-disease-severity-application-to-ugandan-diabetes-data
#9
O D Buhule, A S Wahed, A O Youk
Modeling of correlated biomarkers jointly has been shown to improve the efficiency of parameter estimates, leading to better clinical decisions. In this paper, we employ a joint modeling approach to a unique diabetes dataset, where blood glucose (continuous) and urine glucose (ordinal) measures of disease severity for diabetes are known to be correlated. The postulated joint model assumes that the outcomes are from distributions that are in the exponential family and hence modeled as multivariate generalized linear mixed effects model associated through correlated and/or shared random effects...
August 22, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28798909/analysis-of-urine-composition-in-type-ii-diabetic-mice-after-intervention-therapy-using-holothurian-polypeptides
#10
Yanyan Li, Jiajie Xu, Xiurong Su
Hydrolysates and peptide fractions (PF) obtained from sea cucumber with commercial enzyme were studied on the hyperglycemic and renal protective effects on db/db rats using urine metabolomics. Compared with the control group the polypeptides from the two species could significantly reduce the urine glucose and urea. We also tried to address the compositions of highly expressed urinary proteins using a proteomics approach. They were serum albumins, AMBP proteins, negative trypsin, elastase, and urinary protein, GAPDH, a receptor of urokinase-type plasminogen activator (uPAR), and Ig kappa chain C region...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28771440/association-between-urinary-phthalates-and-metabolic-abnormalities-in-obese-thai-children-and-adolescents
#11
Tansit Saengkaew, Chutima Jantarat, Wichit Nosoognoen, Vichit Supornsilchai
BACKGROUND: Several endocrine disruptors (including phthalates) are considered to be a cause of obesity. However, the current evidence has not conclusively established an association between phthalates and metabolic abnormalities, especially in children. The objective of the study was to evaluate the association between urinary phthalate metabolites and metabolic abnormalities in obese Thai children and adolescents. METHODS: This cross-sectional case-control study was conducted in participants aged 7-18 years and divided into two groups: normal weight and overweight/obesity...
August 28, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28770952/an-effective-indicator-in-predicting-cardiovascular-events-urine-albumin-to-creatinine-ratio
#12
H Zhao, Y-F Jiang, X-C Zhou, L Yao, J Chen, D Wang, D-Y Fu
OBJECTIVE: To study elderly hypertensive patients with trace albuminuria (urine albumin to creatinine ratio (UACR)) and the relationship between the occurrence of new cardiovascular events, to provide a basis for early prevention in elderly patients with high blood pressure. PATIENTS AND METHODS: A total of 3564 elderly patients with high blood pressure were enrolled in the study. Based on UACR, patients were divided into four groups (group A: 0.05-3.20 mg/g; group B:3...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28767064/psoralea-corylifolia-l-seed-extract-attenuates-diabetic-nephropathy-by-inhibiting-renal-fibrosis-and-apoptosis-in-streptozotocin-induced-diabetic-mice
#13
Eunhui Seo, Hwansu Kang, Yoon Sin Oh, Hee-Sook Jun
The Psoralea corylifolia L. seed (PCS) is a widely used herbal medicine, but its possible effect against diabetic nephropathy has not been studied. To investigate the anti-nephropathic effect of PCS extracts, we performed experiments using a diabetic mouse model and high glucose-treated mesangial cells. Streptozotocin (STZ)-induced diabetic mice were orally administered PCS extract for 8 weeks (500 mg/kg/day). Increased creatinine clearance, urine volume, urine microalbumin, and mesangial expansion were observed in STZ-induced diabetic mice; these were significantly reduced by PCS extract administration...
August 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28751823/global-autorecognition-and-activation-of-complement-by-mannan-binding-lectin-in-a-mouse-model-of-type-1-diabetes
#14
Esben Axelgaard, Jakob Appel Østergaard, Saranda Haxha, Steffen Thiel, Troels Krarup Hansen
Increasing evidence links mannan-binding lectin (MBL) to late vascular complications of diabetes. MBL is a complement-activating pattern recognition molecule of the innate immune system that can mediate an inflammation response through activation of the lectin pathway. In two recent animal studies, we have shown that autoreactivity of MBL is increased in the kidney in diabetic nephropathy. We hypothesize that long-term exposure to uncontrolled high blood glucose in diabetes may mediate formation of neoepitopes in several tissues and that MBL is able to recognize these structures and thus activate the lectin pathway...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28728079/probucol-ameliorates-renal-injury-in-diabetic-nephropathy-by-inhibiting-the-expression-of-the-redox-enzyme-p66shc
#15
Shikun Yang, Li Zhao, Yachun Han, Yu Liu, Chao Chen, Ming Zhan, Xiaofen Xiong, Xuejing Zhu, Li Xiao, Chun Hu, Fuyou Liu, Zhiguang Zhou, Yashpal S Kanwar, Lin Sun
AIMS: Probucol is an anti-hyperlipidemic agent and a potent antioxidant drug that can delay progression of diabetic nephropathy (DN) and reverses renal oxidative stress in diabetic animal models; however, the mechanisms underlying these effects remain unclear. p66Shc is a newly recognized mediator of mitochondrial ROS production in renal cells under high-glucose (HG) ambience. We previously showed that p66Shc can serve as a biomarker for renal oxidative injury in DN patients and that p66Shc up-regulation is correlated with renal damage in vivo and in vitro...
July 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28719195/fluorinated-boronic-acid-appended-pyridinium-salts-and-19-f-nmr-spectroscopy-for-diol-sensing
#16
Jörg Axthelm, Sven H C Askes, Martin Elstner, Upendar Reddy G, Helmar Görls, Peter Bellstedt, Alexander Schiller
The identification and discrimination of diols is of fundamental importance in medical diagnostics, such as measuring the contents of glucose in the urine of diabetes patients. Diol sensors are often based on fluorophore-appended boronic acids, but these severely lack discriminatory power and their response is one-dimensional. As an alternative strategy, we present the use of fluorinated boronic acid-appended pyridinium salts in combination with (19)F NMR spectroscopy. A pool of 59 (bio)analytes was screened, containing monosaccharides, phosphorylated and N-acetylated sugars, polyols, carboxylic acids, nucleotides, and amines...
August 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28711247/ratio-of-dietary-rumen-degradable-protein-to-rumen-undegradable-protein-affects-nitrogen-partitioning-but-does-not-affect-the-bovine-milk-proteome-produced-by-mid-lactation-holstein-dairy-cows
#17
R Tacoma, J Fields, D B Ebenstein, Y-W Lam, S L Greenwood
Little is known about the bovine milk proteome or whether it can be affected by diet. The objective of this study was to determine if the dietary rumen degradable protein (RDP):rumen undegradable protein (RUP) ratio could alter the bovine milk proteome. Six Holstein cows (parity: 2.5 ± 0.8) in mid lactation were blocked by days in milk (80 ± 43 d in milk) and milk yield (57.5 ± 6.0 kg) and randomly assigned to treatment groups. The experiment was conducted as a double-crossover design consisting of three 21-d periods...
September 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28703316/the-effect-of-renal-impairment-on-the-pharmacokinetics-and-pharmacodynamics-of-ertugliflozin-in-subjects-with-type-2-diabetes-mellitus
#18
V Sahasrabudhe, S G Terra, A Hickman, D Saur, H Shi, M O'Gorman, Z Zhou, D L Cutler
Ertugliflozin is a highly selective and potent inhibitor of the sodium-glucose cotransporter 2 in development for the treatment of type 2 diabetes mellitus. The glycemic efficacy of sodium-glucose cotransporter 2 inhibitors such as ertugliflozin depends on glucose filtration through the kidney. This phase 1, open-label study evaluated the effect of renal impairment on the pharmacokinetics, pharmacodynamics, and tolerability of ertugliflozin (15 mg) in type 2 diabetes mellitus and healthy subjects with normal renal function (estimated glomerular filtration rate not normalized for body surface area ≥90 mL/min) and type 2 diabetes mellitus subjects with mild (60-89 mL/min), moderate (30-59 mL/min), or severe (<30 mL/min) renal impairment (n = 36)...
July 13, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28692847/microbial-metabolites-are-associated-with-a-high-adherence-to-a-mediterranean-dietary-pattern-using-a-1-h-nmr-based-untargeted-metabolomics-approach
#19
Enrique Almanza-Aguilera, Mireia Urpi-Sarda, Rafael Llorach, Rosa Vázquez-Fresno, Mar Garcia-Aloy, Francesc Carmona, Alex Sanchez, Francisco Madrid-Gambin, Ramon Estruch, Dolores Corella, Cristina Andres-Lacueva
The study of biomarkers of dietary patterns including the Mediterranean diet (MedDiet) is scarce and could improve the assessment of these patterns. Moreover, it could provide a better understanding of health benefits of dietary patterns in nutritional epidemiology. We aimed to determine a robust and accurate biomarker associated with a high adherence to a MedDiet pattern that included dietary assessment and its biological effect. In this cross-sectional study, we included 56 and 63 individuals with high (H-MDA) and low (L-MDA) MedDiet adherence categories, respectively, all from the Prevención con Dieta Mediterránea trial...
October 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28688111/vasopressin-and-metabolic-disorders-translation-from-experimental-models-to-clinical-use
#20
Kazuaki Nakamura, Gilberto Velho, Nadine Bouby
Vasopressin has many physiological actions in addition to its well-defined role in the control of fluid homeostasis and urine concentration. An increasing body of evidence suggests that the vasopressin-hydration axis plays a role in glucose homeostasis. This review summarizes the knowledge accumulated over the last decades about the influence of vasopressin in the short-term regulation of glycemia. It describes the possible role of this hormone through activation of V1a and V1b receptors on liver and pancreas functions and on the hypothalamic-pituitary-adrenal axis...
July 8, 2017: Journal of Internal Medicine
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