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https://www.readbyqxmd.com/read/29781217/uhplc-q-tof-ms-based-screening-and-identification-of-main-flavonoids-and-their-metabolites-in-rats-after-oral-administration-of-cirsium-japonicum-dc-extract
#1
Xia Zhang, Man Liao, Xiaoye Cheng, Caijuan Liang, Xinpeng Diao, Lantong Zhang
RATIONALE: Cirsium japonicum DC., a traditional Chinese medicine, has been shown to have antihemorrhagic and antitumour effects. Pharmacological studies have demonstrated that this curative effect may be related to flavonoids. The present work aims to screen and identify the main flavonoids and their corresponding metabolites in rats after oral administration of Cirsium japonicum DC. extract. METHODS: A rapid and simple ultra-high-performance liquid chromatography coupled with triple quadrupole and time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS) method was developed for the identification of the primary absorbing components and metabolites of the principal flavonoids...
May 20, 2018: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/29781038/downregulation-of-lncrna-malat1-contributes-to-renal-functional-improvement-after-duodenal-jejunal-bypass-in-a-diabetic-rat-model
#2
Dong Wu, Yu-Gang Cheng, Xin Huang, Ming-Wei Zhong, Shao-Zhuang Liu, San-Yuan Hu
Ameliorated renal function has been reported after bariatric surgery, but the mechanisms underlying this phenomenon are not well-studied. To investigate whether the long non-coding RNA (lncRNA) MALAT1 mediates the amelioration of diabetic nephropathy after duodenal-jejunal bypass (DJB) surgery, rats were assigned randomly into four groups: diabetic (DM) group, DM with DJB surgery group, DM with sham surgery group, and healthy control group. Food intake, body weight, oral glucose tolerance test (OGTT), urine albumin excretion rate (UAER), and glomerular filtration rate (GFR) were measured and histological examination of renal sections was performed...
May 21, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29766441/metabolomic-analysis-and-biochemical-changes-in-the-urine-and-serum-of-streptozotocin-induced-normal-and-obese-diabetic-rats
#3
Ahmed Mediani, Faridah Abas, M Maulidiani, Azliana Abu Bakar Sajak, Alfi Khatib, Chin Ping Tan, Intan Safinar Ismail, Khozirah Shaari, Amin Ismail, N H Lajis
Diabetes mellitus (DM) is a chronic disease that can affect metabolism of glucose and other metabolites. In this study, the normal- and obese-diabetic rats were compared to understand the diabetes disorders of type 1 and 2 diabetes mellitus. This was done by evaluating their urine metabolites using proton nuclear magnetic resonance (1 H NMR)-based metabolomics and comparing with controls at different time points, considering the induction periods of obesity and diabetes. The biochemical parameters of the serum were also investigated...
May 15, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29766170/design-of-a-wearable-device-for-real-time-screening-of-urinary-tract-infection-and-kidney-disease-based-on-smartphone
#4
Jianyu Zhou, Tao Dong
In this study, we developed a novel wearable and low-cost device for qualitative screening of glucose (GLU), leukocytes (LEU), and nitrite (NIT) and for semi-quantitative analysis of blood (BLD) and proteins (PRO) in the urine samples. The device can be attached to a diaper, and the results can be read by an app. The main functions of the device can be divided into sample collection, valve closing, and pad saturation; the recorded times for valve closing and pad saturation at four corners and pad saturation at the central parts are pseudo-medians (Hodges-Lehmann estimator) of 3...
May 16, 2018: Analyst
https://www.readbyqxmd.com/read/29753982/does-urinary-bisphenol-a-change-after-bariatric-surgery
#5
Carl L Dambkowski, Luis Garcia, Natalia Leva, John M Morton
BACKGROUND: One of the world's highest volume chemicals is bisphenol-A (BPA), an organic compound with a high solubility in fat. An emerging body of literature has suggested a link between BPA and obesity and insulin resistance. The study aim is to determine if surgical weight loss is associated with changes in BPA levels. METHODS: Demographic, preoperative, and 3, 6, and 12 month postoperative urine and laboratory data were prospectively collected on 22 bariatric surgery patients at a single academic institution...
May 10, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29752082/pvc-membrane-coated-wire-and-carbon-paste-ion-selective-electrodes-for-potentiometric-determination-of-galantamine-hydrobromide-in-physiological-fluids
#6
Fatehy M Abdel-Haleem, Mohamed Saad, Ahmed Barhoum, Mikhael Bechelany, Mahmoud S Rizk
We report on highly-sensitive ion-selective electrodes (ISEs) for potentiometric determining of galantamine hydrobromide (GB) in physiological fluids. Galantamine hydrobromide (GB) was selected for this study due to its previous medical importance for treating Alzheimer's disease. Three different types of ISEs were investigated: PVC membrane electrode (PVCE), carbon-paste electrode (CPE), and coated-wire electrode (CWE). In the construction of these electrodes, galantaminium-reineckate (GR) ion-pair was used as a sensing species for GB in solutions...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29744365/high-salt-intake-ameliorates-hyperglycemia-and-insulin-resistance-in-wbn-kob-lepr-fa-fa-rats-a-new-model-of-type-2-diabetes-mellitus
#7
Yoshiichi Takagi, Taichi Sugimoto, Masaya Kobayashi, Mitsuyuki Shirai, Fumitoshi Asai
High-salt intake is a major risk factor for developing hypertension in type 2 diabetes mellitus, but its effects on glucose homeostasis are controversial. We previously found that high-salt intake induces severe hypertension in WBN/Kob diabetic fatty (WBKDF) rats. In the present study, we examined the effects of a high-salt intake on glucose homeostasis in WBKDF rats. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided into two groups and fed either a normal-sodium (NS, 0.26%) diet or high-sodium (HS, 8%) diet for 7 weeks...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29736297/anti-diabetic-activity-of-quercetin-extracted-from-phyllanthus-emblica-l-fruit-in-silico-and-in-vivo-approaches
#8
Prabhu Srinivasan, S Vijayakumar, Swaminathan Kothandaraman, Manogar Palani
In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferator-activated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin (STZ)-induced diabetic rats was examined...
April 2018: Journal of Pharmaceutical Analysis
https://www.readbyqxmd.com/read/29691708/generation-of-insulin-deficient-piglets-by-disrupting-ins-gene-using-crispr-cas9-system
#9
Bumrae Cho, Su Jin Kim, Eun-Jin Lee, Sun Mi Ahn, Jin Seok Lee, Dal-Young Ji, Kiho Lee, Jung-Taek Kang
Diabetes mellitus is a chronic disease with accompanying severe complications. Various animal models, mostly rodents due to availability of genetically modified lines, have been used to investigate the pathophysiology of diabetes. Using pigs for diabetic research can be beneficial because of their similarity in size, pathogenesis pathway, physiology, and metabolism with human. However, the use of pigs for diabetes research has been hampered due to only few pig models presenting diabetes symptoms. In this study, we have successfully generated insulin-deficient pigs by generating the indels of the porcine INS gene in somatic cells using CRISPR/Cas9 system followed by somatic cell nuclear transfer...
April 24, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29675567/human-urine-derived-stem-cells-play-a-novel-role-in-the-treatment-of-stz-induced-diabetic-mice
#10
Tianxue Zhao, Deng Luo, Yun Sun, Xin Niu, Yang Wang, Chen Wang, Weiping Jia
Human urine-derived stem cells (hUSCs) are a potential stem cell source for cell therapy. However, the effect of hUSCs on glucose metabolism regulation in type 1 diabetes was not clear. Therefore, the aim of the study was to evaluate whether hUSCs have protective effect on streptozotocin (STZ)-induced diabetes. hUSCs were extracted and cultivated with a special culture medium. Flow cytometry analysis was applied to detect cell surface markers. BALB/c male nude mice were either injected with high-dose STZ (HD-STZ) or multiple low-dose STZ (MLD-STZ)...
April 19, 2018: Journal of Molecular Histology
https://www.readbyqxmd.com/read/29672270/role-of-atrial-natriuretic-peptide-in-controlling-diabetic-nephropathy-in-rats
#11
Lakhwinder Singh, Atul Arya, Sumeet Gupta
BACKGROUND: Diabetes is a downregulator of atrial natriuretic peptide (ANP), resulting in reduced nitric oxide level and low expression of endothelial nitric oxide synthase by which nitric oxide level get reduced. In the present study, we examined the role of ANP in reduced nitric oxide level, which may be responsible in controlling diabetic nephropathy in rats. METHODS: Serum nitrite/nitrate ratio, blood urea nitrogen, protein in urine, urinary output, serum creatinine, serum cholesterol, kidney weight, kidney hypertrophy, renal cortical collagen content, thiobarbituric acid level, and antioxidant enzymatic activities were assessed...
April 19, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29659678/test-cost-and-test-accuracy-in-clinical-laboratories-in-kampala-uganda
#12
Timothy K Amukele, Robert Jones, Ali Elbireer
Objectives: To assess the accuracy and costs of laboratory tests in Kampala, Uganda. Methods: A random selection of 78 laboratories tested external quality assurance samples at market rates. There were 40 moderate- to high-complexity and 38 low-complexity laboratories. Four percent (3/78) of these laboratories were accredited and 94% (73/78) were private. The 40 moderate- to high-complexity laboratories performed malaria blood smear, urine human chorionic gonadotropin (hCG), human immunodeficiency virus (HIV), syphilis, glucose, and three-panel tests: CBC, liver function tests, and kidney function tests...
April 5, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29622755/effects-of-pharmacological-reversal-of-hyperuricemia-on-features-of-the-metabolic-syndrome-in-patients-with-gouty-arthritis
#13
Mariana Marin, Naim M Maalouf
Hyperuricemia has been associated in epidemiological studies with the development of obesity, hypertension, insulin resistance and type 2 diabetes. Nevertheless, it remains unclear whether lowering of serum uric acid (UA) alters any of the features of the metabolic syndrome. In this prospective study (ClinicalTrials.gov identifier: NCT01654276), 24 patients with gouty arthritis and hyperuricemia were treated for 6 months with the xanthine oxidase inhibitor febuxostat to lower serum UA to <6 mg/dL. Measurements of 24 hours ambulatory blood pressure (ABP) and serum and urine markers of the metabolic syndrome were measured at baseline and at the end of 6 months of febuxostat...
April 4, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29604956/berberine-ameliorates-diabetic-nephropathy-by-inhibiting-tlr4-nf-%C3%AE%C2%BAb-pathway
#14
Liping Zhu, Jiakai Han, Rongrong Yuan, Lei Xue, Wuyan Pang
BACKGROUND: Diabetic nephropathy (DN) is the leading cause of end-stage renal failure, contributing to severe morbidity and mortality in diabetic patients. Berberine (BBR) has been well characterized to exert renoprotective effects in DN progression. However, the action mechanism of BBR in DN remains to be fully understood. METHODS: The DN rat model was generated by intraperitoneal injection of streptozotocin (STZ, 65 mg/kg body weight) while 30 mM high glucose (HG)-treated podocytes were used as an in vitro DN model...
March 31, 2018: Biological Research
https://www.readbyqxmd.com/read/29575530/novel-application-of-the-two-period-microtracer-approach-to-determine-absolute-oral-bioavailability-and-fraction-absorbed-of-ertugliflozin
#15
Sangeeta Raje, Ernesto Callegari, Vaishali Sahasrabudhe, Alfin Vaz, Haihong Shi, Eric Fluhler, Eric J Woolf, Klaas Schildknegt, Kyle Matschke, Christine Alvey, Susan Zhou, Dimitris Papadopoulos, Robert Fountaine, Didier Saur, Steven G Terra, Lloyd Stevens, Daniel Gaunt, David L Cutler
Ertugliflozin, a sodium glucose cotransporter-2 inhibitor, is approved in the United States for treatment of type 2 diabetes mellitus. A novel two-period study design with14 C microtracer dosing in each period was used to determine absolute oral bioavailability (F) and fraction absorbed (Fa ) of ertugliflozin. Eight healthy adult men received 100-μg i.v.14 C-ertugliflozin (400 nCi) dose 1 h after a 15-mg oral unlabeled ertugliflozin dose (period 1), followed by 100 μg14 C-ertugliflozin orally along with 15 mg oral unlabeled ertugliflozin (period 2)...
March 25, 2018: Clinical and Translational Science
https://www.readbyqxmd.com/read/29574249/nanostructured-silver-fabric-as-a-free-standing-nanozyme-for-colorimetric-detection-of-glucose-in-urine
#16
Md N Karim, Samuel R Anderson, Sanjay Singh, Rajesh Ramanathan, Vipul Bansal
Enzyme-mimicking catalytic nanoparticles, more commonly known as NanoZymes, have been at the forefront for the development of new sensing platforms for the detection of a range of molecules. Although solution-based NanoZymes have shown promise in glucose detection, the ability to immobilize NanoZymes on highly absorbent surfaces, particularly on free-standing substrates that can be feasibly exposed and removed from the reaction medium, can offer significant benefits for a range of biosensing and catalysis applications...
March 13, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29574005/prevalence-and-risk-factors-associated-with-chronic-kidney-disease-in-adults-living-in-3-different-altitude-regions-in-the-tibetan-plateau
#17
Linfeng Zhang, Zengwu Wang, Yundai Chen, Xin Wang, Zuo Chen, Bin Feng, Qinglei Zhu, Jingyu Nie, Ying Dong, Shanshan Zhou, Ye Tian, Lan Shao, Manlu Zhu
BACKGROUND: Living at high altitude may have undesirable effects on the kidney. We explored the chronic kidney disease (CKD) prevalence and risk factors among the residents living at different altitude in Tibetan Plateau. METHODS: A cross-sectional study was carried out in 2014 to 2016 in Linzhi (2900 m altitude), Lhasa (3650 m) and Anduo (4700 m). Information on the cardiovascular risk factors was collected and blood and urine samples were measured. RESULTS: The data of 1707 subjects aged ≥35 y were analyzed...
June 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29523776/combination-of-luteolin-and-solifenacin-improves-urinary-dysfunction-induced-by-diabetic-cystopathy-in-rats
#18
Jing Xu, Hong Xu, Yang Yu, Yi He, Qi Liu, Bo Yang
BACKGROUND The purpose of the present study was to assess the effect of luteolin and solifenacin on diabetic cystopathy (DCP) and to investigate the mechanism of action. A novel link between the overexpression of c-Kit in the bladder and voiding dysfunction was identified in rats with DCP. MATERIAL AND METHODS A rat model of DCP was successfully established by intraperitoneal injection of streptozotocin and a diet high in glucose and lipids, and animals were treated with luteolin and solifenacin. The effect of luteolin and solifenacin on urinary dysfunction in DCP rats was investigated by assessing bladder pressure and performing a volume test...
March 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29519756/effects-of-cannabis-use-on-body-mass-fasting-glucose-and-lipids-during-the-first-12-months-of-treatment-in-schizophrenia-spectrum-disorders
#19
F Scheffler, S Kilian, B Chiliza, L Asmal, L Phahladira, S du Plessis, M Kidd, R M Murray, M Di Forti, S Seedat, R Emsley
While acute cannabis use stimulates appetite, general population studies suggest that chronic use is associated with reduced risk of obesity and other cardiometabolic risk factors. In this study we investigated changes in body mass index (BMI), fasting blood glucose and lipids, and rates of metabolic syndrome risk factors in cannabis users vs. non-users in 109 minimally treated patients with first-episode schizophrenia, schizophreniform or schizo-affective disorder who were treated according to a standardized treatment regime with depot antipsychotic medication over 12 months...
March 6, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29519318/kidney-protection-effects-of-dihydroquercetin-on-diabetic-nephropathy-through-suppressing-ros-and-nlrp3-inflammasome
#20
Tao Ding, Shaofei Wang, Xuyao Zhang, Wenjing Zai, Jiajun Fan, Wei Chen, Qi Bian, Jingyun Luan, Yilan Shen, Yanda Zhang, Dianwen Ju, Xiaobin Mei
BACKGROUND: Diabetic nephropathy (DN), the leading cause of end-stage renal disease, is acknowledged as an independent risk factor for cardiovascular disease, which underlines the urgent need for new medications to DN. Dihydroquercetin (DHQ), an important natural dihydroflavone, exerts significant antioxidant, anti-inflammatory, and antifibrotic properties, but its effects on DN have not been investigated yet. PURPOSE: We aimed to explore the kidney protection effects of DHQ on DN rats induced by high-fat diet/streptozotocin in vivo and the underlying mechanisms of DHQ on renal cells including HBZY-1 and HK2 exposed to high glucose in vitro...
March 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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