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https://www.readbyqxmd.com/read/29352520/ipragliflozin-improves-mitochondrial-abnormalities-in-renal-tubules-induced-by-a-high-fat-diet
#1
Susumu Takagi, Jinpeng Li, Yuta Takagaki, Munehiro Kitada, Kyoko Nitta, Toshiyuki Takasu, Keizo Kanasaki, Daisuke Koya
OBJECTIVE: Complete mechanisms of reno-protective effects of SGLT2 inhibitors have not been elucidated yet. Mitochondrial biogenesis is regulated by membrane GTPases, such as Opa1 and Mfn2. Here, we investigated whether SGLT2 inhibition in mice fed with a high-fat diet (HFD) improved mitochondrial morphology and restored mitochondrial biogenesis-related molecules. MATERIALS AND METHODS: Mice were fed in control diet or HFD with or without ipragliflozin treatment...
January 20, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29343229/the-colombo-twin-and-singleton-follow-up-study-a-population-based-twin-study-of-psychiatric-disorders-and-metabolic-syndrome-in-sri-lanka
#2
Kaushalya Jayaweera, Lisa Aschan, Gayani Pannala, Anushka Adikari, Nicholas Glozier, Khalida Ismail, Carmine M Pariante, Fruhling Rijsdijk, Sisira Siribaddana, Helena M S Zavos, Patricia A Zunszain, Athula Sumathipala, Matthew Hotopf
BACKGROUND: The disease burden related to mental disorders and metabolic syndrome is growing in low-and middle-income countries (LMIC). The Colombo Twin and Singleton Study (COTASS) is a population-based sample of twins and singletons in Colombo, Sri Lanka. Here we present prevalence estimates for metabolic syndrome (metS) and mental disorders from a follow-up (COTASS-2) of the original study (COTASS-1), which was a mental health survey. METHODS: In COTASS-2, participants completed structured interviews, anthropometric measures and provided fasting blood and urine samples...
January 17, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29322544/role-of-bisphenol-a-as-environmental-factor-in-the-promotion-of-non-alcoholic-fatty-liver-disease-in%C3%A2-vitro-and-clinical-study
#3
M Dallio, M Masarone, S Errico, A G Gravina, C Nicolucci, R Di Sarno, L Gionti, C Tuccillo, M Persico, P Stiuso, N Diano, C Loguercio, A Federico
BACKGROUND: Bisphenol A is an endocrine disrupting chemical associated with type 2 diabetes mellitus (T2DM), cardiovascular disease and liver enzyme abnormalities. AIM: To evaluate bisphenol A plasma and urine levels in non-alcoholic fatty liver disease (NAFLD) patients compared to healthy subjects. Furthermore, we evaluated, in human HepG2 cells, the effects of exposure to different concentrations of bisphenol A on both oxidative stress induction and cell proliferation...
January 11, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29319179/muscle-derived-satellite-cells-for-treating-type-1-diabetes-in-rats-rattus-norvegicus
#4
Yu Ren, Hefei Wang, Si Ha, Xingsheng Zhao, Xiao Wang, Yu Lan, Xiaoling Liu
Diabetes mellitus(DM) is a complicated metabolic disease, with the fundamental treatment nowadays being diet control, insulin injections, slet or pancreas transplantation, which is limited because exogenous insulin injections fail to simulate normal insulin secretion in islet beta cells successfully and islet transplantation lacks organ donors. So far, stem cells with highly self-renewal and multi-directional differentiation potential have become a new hope for the treatment of diabetes. In this research, rat Muscle-derived satellite cells *MDSCs*were separated and cultivated in vitro and inducted into insulin-producing cells with observation and identification using dithizone staining and so on...
January 10, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29291105/nanostructured-carbon-electrode-modified-with-n-doped-graphene-quantum-dots-chitosan-nanocomposite-a-sensitive-electrochemical-dopamine-sensor
#5
Sami Ben Aoun
A highly selective and sensitive dopamine electrochemical sensor based on nitrogen-doped graphene quantum dots-chitosan nanocomposite-modified nanostructured screen printed carbon electrode is presented, for the first time. Graphene quantum dots were prepared via microwave-assisted hydrothermal reaction of glucose, and nitrogen doping was realized by introducing ammonia in the reaction mixture. Chitosan incorporation played a significant role towards the selectivity of the prepared sensor by hindering the ascorbic acid interference and enlarging the peak potential separation between dopamine and uric acid...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29249162/dietary-apostichopus-japonicus-alleviates-diabetes-symptoms-and-modulates-genes-expression-in-kidney-tissues-of-db-db-mice
#6
Lisha Dong, Yanyan Li, Dijun Zhang, Hongyan Zhang, Jiaojiao Han, Zhaoyang Wang, Jun Zhou, Chenyang Lu, Xiurong Su
The effects of Apostichopus japonicus enzymatic hydrolysate on the regulation of dyslipidemia, pathoglycemia, and transcription changes in kidney tissues of db/db mice were evaluated. In this study, the symptoms of diabetes in db/db mice were alleviated after 10 weeks of treatments with low (db/db + LD group) and high dose (db/db + HD group) of Apostichopus japonicus enzymatic hydrolysate, and the high dose treatment showed a better antidiabetic effect. Compared with the db/db group, the fasting blood glucose levels (36...
January 10, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29242971/effects-of-hydration-on-plasma-copeptin-glycemia-and-gluco-regulatory-hormones-a-water-intervention-in-humans
#7
Sofia Enhörning, Irina Tasevska, Ronan Roussel, Nadine Bouby, Margaretha Persson, Philippe Burri, Lise Bankir, Olle Melander
PURPOSE: High plasma copeptin, a marker of vasopressin, predicts diabetes mellitus. We tested if copeptin could be suppressed by increased water intake in healthy individuals, and if a water-induced change in copeptin was accompanied by altered concentrations of glucose, insulin or glucagon. METHODS: Thirty-nine healthy individuals underwent, in random order, 1 week of high water intake (3 L/day on top of habitual intake) and 1 week of normal (habitual) fluid intake (control)...
December 14, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/29242399/novel-functional-renal-imaging-with-18f-fds-pet-in-rat-models-of-kidney-diseases
#8
Rudolf Werner, Hiroshi Wakabayashi, Xinyu Chen, Mitsuru Hirano, Tetsuya Shinaji, Constantin Lapa, Steven P Rowe, Mehrbod S Javadi, Takahiro Higuchi
Background: Precise regional quantitative assessment of renal function is limited with conventional 99mTc-labeled renal radiotracers. A recent study reported that the positron emission tomography (PET) radiotracer 2-deoxy-2-18F-fluorosorbitol (18F-FDS) has ideal pharmacokinetics for functional renal imaging. Furthermore, 18F-FDS is available via simple reduction from routinely used 2-deoxy-2-18F-fluoro-D-glucose (18F-FDG). We aimed to further investigate the potential of 18F-FDS PET as a functional renal imaging agent using rat models of kidney diseases...
December 14, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29233709/metabolomics-analysis-of-alloxan-induced-diabetes-in-mice-using-uplc-q-tof-ms-after-crassostrea-gigas-polysaccharide-treatment
#9
Guanhua Zhao, Xilong Hou, Xingyao Li, Min Qu, Changqing Tong, Wei Li
Diabetes has become a global and serious health issues which causes a variety of complications. This study aims to explore the hypoglycemic effect of Crassostrea gigas polysaccharide (CGPS) and the dynamic changes in the endogenous small molecule metabolites of urine from normal group, model group and CGPS high dose group by metabolomic approach (UPLC-Q-TOF-MS). In our study, the CGPS treatment could reduce the fasting blood glucose levels and recover the triglycerides (TG), total cholesterol (TC) and glycosylated serum protein (GSP) levels in serum of diabetic mice...
December 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29214987/influence-of-c-reactive-protein-on-the-occurrence-and-assessing-of-albuminuria-severity-in-diabetics
#10
Lamija Pojskić, Sabaheta Hasić, Ema Tahto, Vildana Arnautović-Torlak, Belma Pojskić
Aim To asses relation of serum high sensitive C-reactive protein (hsCRP) level with albumin concentration in daily urine in patients with diabetes mellitus type 2 (T2DM). Methods The prospective study included 69 patients with T2DM, both sexes (24 males, 45 females), aged 30-82 years. They were divided into two groups: patients with T2DM and normoalbuminuria(T2DM-NA; n=40) and patients with T2DM and microalbuminuria (T2DM-MA; n=29). Patients were hospitalized at the Department of Internal Medicine, Cantonal Hospital Zenica, in the period January-April 2014...
February 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29209478/association-between-sarcopenia-and-dipstick-proteinuria-in-the-elderly-population-the-korea-national-health-and-nutrition-examination-surveys-2009-2011
#11
Duna Hwang, Mi-Ryung Cho, Minyong Choi, Sang Hyun Lee, Youngmin Park
Background: Sarcopenia and proteinuria are significant health difficulties in the elderly; however, few studies have investigated their relationship. In this study, we investigated the association between sarcopenia and proteinuria in Korean subjects over 60 years old. Methods: We included data from the Korean National Health and Nutrition Examination Survey, a cross-sectional, nationally representative survey conducted from 2009 to 2011 (n=4,008). Sarcopenia was defined using appendicular skeletal muscle mass as a percentage of body weight...
November 2017: Korean Journal of Family Medicine
https://www.readbyqxmd.com/read/29207691/a-comparative-study-of-high-sensitivity-c-reactive-protein-and-metabolic-variables-in-type-2-diabetes-mellitus-with-and-without-nephropathy
#12
Abid K Shaheer, Jithesh K Tharayil, Parvathi W Krishna
Introduction: Diabetic nephropathy is a serious chronic complication of Type 2 Diabetes Mellitus (T2DM) which impairs the quality of life, leading to increased morbidity and mortality. The high sensitivity C-reactive protein (hs-CRP) is an acute phase reactant which acts as a non-specific systemic marker of inflammation. Aim: To find out the relationship between serum hs-CRP and metabolic variables in Type 2 diabetic patients with and without nephropathy. Materials and Methods: The study group consists of 96 subjects that include non-diabetic healthy controls, Type 2 diabetic patients without any complications and patients with diabetic nephropathy...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29199440/annals-express-a-study-of-high-middle-and-low-molecular-weight-adiponectin-in-urine-as-a-surrogate-marker-for-early-diabetic-nephropathy-using-ultra-sensitive-ict-eia
#13
Mayumi Yamamoto, Yuki Hujimoto, Shino Hayashi, Seiichi Hashida
BACKGROUND: For the early identification of patients at risk of developing diabetic nephropathy, we have developed an ultra-sensitive immune complex transfer enzyme immunoassay (ICT-EIA) to measure adiponectin in urine. METHODS: We developed ICT-EIA for adiponectin and measured urinary adiponectin from 70 healthy subjects, 35 obese non-diabetic subjects and 20 patients with diabetes. RESULTS: The urinary adiponectin levels in patients with diabetes (3...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29193741/energy-expenditure-and-hormone-responses-in-humans-after-overeating-high-fructose-corn-syrup-versus-whole-wheat-foods
#14
Mostafa Ibrahim, Susan Bonfiglio, Mathias Schlögl, Karyne L Vinales, Paolo Piaggi, Colleen Venti, Mary Walter, Jonathan Krakoff, Marie S Thearle
OBJECTIVE: This study sought to understand how the dietary source of carbohydrates, either high-fructose corn syrup (HFCS) or complex carbohydrates, affects energy expenditure (EE) measures, appetitive sensations, and hormones during 24 hours of overfeeding. METHODS: Seventeen healthy participants with normal glucose regulation had 24-hour EE measures and fasting blood and 24-hour urine collection during four different 1-day diets, including an energy-balanced diet, fasting, and two 75% carbohydrate diets (5% fat) given at 200% of energy requirements with either HFCS or whole-wheat foods as the carbohydrate source...
January 2018: Obesity
https://www.readbyqxmd.com/read/29181745/salicylate-intoxication-in-an-infant-a-case-report
#15
Rita Espírito Santo, Sara Vaz, Filipa Jalles, Leonor Boto, Francisco Abecasis
In children, the most common cause of an elevated anion gap (AG) with ketonemia, ketonuria, hyperglycemia, and glycosuria is diabetic ketoacidosis. However, when the clinical history is not clear, other causes must be considered. A 9-month-old girl was transferred to our pediatric intensive care unit (PICU) because of severe metabolic acidosis. On admission, she presented with Kussmaul breathing, tachycardia, irritability, and fever. Blood gasses revealed metabolic acidosis with superimposed respiratory alkalosis and elevated AG...
November 27, 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/29176961/clinical-and-biochemical-associations-with-diabetic-retinopathy-in-male-patients-in-the-gaza-strip
#16
Ayman M AbuMustafa
Background: There are limited data on the prevalence and risk factors for diabetic retinopathy (DR) in the Gaza Strip. Objective: To assesses clinical and biochemical associated with DR in males with type 2 diabetes mellitus (T2DM) in the Gaza Strip. Methods: One hundred and fifty males with T2DM from the Gaza Strip underwent a questionnaire interview, serum biochemical analysis, and assessment of their previous urine and blood results. Results: The prevalence of DR was 24...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29151417/-effect-of-early-use-of-different-doses-of-enteral-nutrition-on-prognosis-of-patients-with-acute-respiratory-failure
#17
Jianting Gao, Qiuyan Wang
OBJECTIVE: To observe the impact of initial low-dose (trophic type) enteral nutrition (EN) support on mechanical ventilation (MV) time, the incidence of complications and survival rate in patients with acute respiratory failure (ARF). METHODS: A prospective study was conducted. Forty-four patients with ARF undergoing MV admitted to Department of Critical Care Medicine of Hangzhou Traditional Chinese Medical Hospital from September 2015 to February 2017 were enrolled, and they were divided into a trophic feeding group (n = 23, study group) and a standard-dose feeding group (n = 21, control group)...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29144608/the-relationship-between-urine-ph-and-abnormal-glucose-tolerance-in-a-community-based-study
#18
Sakiko Yoshida, Teruki Miyake, Shin Yamamoto, Shinya Furukawa, Tetsuji Niiya, Hidenori Senba, Sayaka Kanzaki, Osamu Yoshida, Toru Ishihara, Mitsuhito Koizumi, Masashi Hirooka, Teru Kumagi, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa
AIMS/INTRODUCTION: The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we conducted a community-based, cross-sectional study to investigate sex-specific associations between these values, possible indicators of prediabetes, and type 2 diabetes. MATERIALS AND METHODS: We enrolled 4,945 Japanese subjects (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, subjects were divided into three groups based on their fasting plasma glucose levels (<6...
November 16, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29129845/microalbuminuria-is-associated-with-lower-weight-and-taller-height-in-adolescence
#19
Myung Hyun Cho, Kyo Sun Kim, Sochung Chung
Microalbuminuria (MA) is a well-known predictor of cardiovascular disease and mortality in adults. However, these relationships remain unclear in adolescents. A few studies on association between MA and obesity have been conducted in adolescents. However, the association between MA and growth parameters such as height has not been studied, despite the fact that adolescence is a period of rapid physiological change. We, therefore, aimed to evaluate the association between MA and growth parameters, and the association between MA and obesity related cardiovascular risk factors after adjusting for growth...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29114945/hyperglycaemia-induced-by-chronic-i-p-and-oral-glucose-loading-leads-to-hypertension-through-increased-na-retention-in-proximal-tubule
#20
Selim Fakhruddin, Wael A Alanazi, Hussain N Alhamami, Karen P Briski, Keith E Jackson
What is the central question of the study? Chronic glucose feeding accompanied by glucose injection (i.p.) causes sustained hyperglycaemia and hypertension in rats. The exact reason for the hypertension is not known. We explore some molecular pathways of the renal proximal tubule that might promote Na+ retention. What is the main finding and its importance? Development of hypertension was mediated by upregulation of the renal renin-angiotensin system and oxidative stress, acting via the Na+ -K+ -ATPase α1 -subunit in the proximal tubule, which appears to pump intracellular Na+ into the extracellular space, increasing Na+ reabsorption and blood pressure...
November 7, 2017: Experimental Physiology
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