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https://www.readbyqxmd.com/read/28224182/parp-inhibition-ameliorates-nephropathy-in-an-animal-model-of-type-2-diabetes-focus-on-oxidative-stress-inflammation-and-fibrosis
#1
Esraa M Zakaria, Nabila N El-Maraghy, Ahmed F Ahmed, Abdelmonim A Ali, Hany M El-Bassossy
Poly(ADP-ribose) polymerase (PARP) enzyme contributes to nephropathy, a serious diabetic complication which may lead to end-stage renal disease. The study aims to investigate the effect of PARP over-activation on kidney functions in a type 2 diabetic rat model. The study also tests the therapeutic use of PARP inhibitors in diabetic nephropathy. Type 2 diabetes was induced in adult male rats by high-fructose/high-fat diet and low streptozotocin dose. Then, the PARP inhibitor 4-aminobenzamide (4-AB) was administered daily for 10 weeks...
February 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28213261/a-method-for-the-analysis-of-sugars-in-biological-systems-using-reductive-amination-in-combination-with-hydrophilic-interaction-chromatography-and-high-resolution-mass-spectrometry
#2
Sami Bawazeer, Ali Muhsen Ali, Aliyah Alhawiti, Abedawn Khalaf, Colin Gibson, Jonans Tusiimire, David G Watson
Separation of sugar isomers extracted from biological samples is challenging because of their natural occurrence as alpha and beta anomers and, in the case of hexoses, in their pyranose and furanose forms. A reductive amination method was developed for the tagging of sugars with the aim of it becoming part of a metabolomics work flow. The best separation of the common hexoses (glucose, fructose, mannose and galactose) was achieved when (2)H5-aniline was used as the tagging reagent in combination with separation on a ZICHILIC column...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28208306/highly-specific-bacteriophage-affinity-strategy-for-rapid-separation-and-sensitive-detection-of-viable-pseudomonas-aeruginosa
#3
Yong He, Mengyao Wang, Enci Fan, Hui Ouyang, Huan Yue, Xiaoxiao Su, Guojian Liao, Lin Wang, Shuguang Lu, Zhifeng Fu
A virulent bacteriophage highly specific to Pseudomonas aeruginosa (P. aeruginosa) was isolated from hospital sewage using a lambda bacteriophage isolation protocol. The bacteriophage, named as PAP1, was used to functionalize tosyl-activated magnetic beads to establish a bacteriophage-affinity strategy for separation and detection of viable P. aeruginosa. Recognition of the target bacteria by tail fibers and baseplate of the bacteriophage led to capture of P. aeruginosa onto the magnetic beads. After a replication cycle of about 100 min, the progenies lysed the target bacteria and released the intracellular adenosine triphosphate...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207721/clinical-anatomy-e-cases-a-five-year-follow-up-of-learning-analytics
#4
Geoffrey Braatvedt, Amelia Tekiteki, Holly Britton, John Wallace, Manish Khanolkar
AIMS: To examine the length of stay and need for intensive care of people admitted with diabetic ketoacidosis (DKA) to a single centre between 1988 and 2011. METHODS: Patients aged ≥15 years admitted for the first time with DKA (plasma glucose ≥ 10mmol/L and a bicarbonate concentration ≤15mmol/L and a pH <7.35, and raised plasma or urine ketones or anion gap) to Auckland City Hospital from 1988-2011 were identified retrospectively. The patients were divided into four cohorts (1988-1996; 1997-2001; 2002-2006; 2007-2011)...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28164667/albuminuria-is-suggested-as-a-potential-health-screening-biomarker-for-senior-citizens-and-general-population-with-hypertension-or-diabetes-in-china
#5
Dongmei Gu, Pengcheng Xu, Yuhua Yuan, Hongwei Fu
BACKGROUND: To evaluate the possibility of albuminuria as a screening biomarker for seniors or general population with hypertension and diabetes. METHODS: 478 health check-up individuals were enrolled. Albumin to creatinine ratio (ACR) was calculated by testing urinary albumin and creatinine of spot urine sample. Each urine sample was also analyzed by the routine urine test in parallel with ACR. Potential risk factors associated with the presence of albuminuria were analyzed using independent t-test or chi-square test...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164659/analysis-of-four-automated-urinalysis-systems-compared-to-reference-methods
#6
Kamila Bartosova, Zdenek Kubicek, Janka Franekova, Gustav Louzensky, Petra Lavrikova, Antonin Jabor
BACKGROUND: The aim of this study was to compare four automated urinalysis systems: the Iris iQ200 Sprint (Iris Diagnostics, U.S.A.) combined with the Arkray AUTION MAX AX 4030, Iris + AUTION, Arkray AU 4050 (Arkray Global Business, Inc., Japan), Dirui FUS 2000 (Dirui Industrial Co., P.R.C.), and Menarini sediMAX (Menarini, Italy). METHODS: Urine concentrations of protein and glucose (Iris, Dirui) were compared using reference quantitative analysis on an Abbott Architect c16000...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28153514/association-of-acute-toxic-encephalopathy-with-litchi-consumption-in-an-outbreak-in-muzaffarpur-india-2014-a-case-control-study
#7
Aakash Shrivastava, Anil Kumar, Jerry D Thomas, Kayla F Laserson, Gyan Bhushan, Melissa D Carter, Mala Chhabra, Veena Mittal, Shashi Khare, James J Sejvar, Mayank Dwivedi, Samantha L Isenberg, Rudolph Johnson, James L Pirkle, Jon D Sharer, Patricia L Hall, Rajesh Yadav, Anoop Velayudhan, Mohan Papanna, Pankaj Singh, D Somashekar, Arghya Pradhan, Kapil Goel, Rajesh Pandey, Mohan Kumar, Satish Kumar, Amit Chakrabarti, P Sivaperumal, A Ramesh Kumar, Joshua G Schier, Arthur Chang, Leigh Ann Graham, Thomas P Mathews, Darryl Johnson, Liza Valentin, Kathleen L Caldwell, Jeffery M Jarrett, Leslie A Harden, Gary R Takeoka, Suxiang Tong, Krista Queen, Clinton Paden, Anne Whitney, Dana L Haberling, Ram Singh, Ravi Shankar Singh, Kenneth C Earhart, A C Dhariwal, L S Chauhan, S Venkatesh, Padmini Srikantiah
BACKGROUND: Outbreaks of unexplained illness frequently remain under-investigated. In India, outbreaks of an acute neurological illness with high mortality among children occur annually in Muzaffarpur, the country's largest litchi cultivation region. In 2014, we aimed to investigate the cause and risk factors for this illness. METHODS: In this hospital-based surveillance and nested age-matched case-control study, we did laboratory investigations to assess potential infectious and non-infectious causes of this acute neurological illness...
January 30, 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28153291/highly-sensitive-detection-of-glucose-a-quantitative-approach-employing-nanorods-assembled-plasmonic-substrate
#8
Qiulan Chen, Yu Fu, Weihong Zhang, Suibo Ye, Hao Zhang, Fangyan Xie, Li Gong, Zhanxiao Wei, Haoyu Jin, Jian Chen
Sensitive glucose detection enables indirect blood glucose sensing through easily accessible biofluids such as saliva and sweat. In this work, silver coated gold nanorods (Au@Ag NRs) were synthesized and used to prepare plasmonic substrate for surface-enhanced Raman spectroscopy (SERS) to leverage highly sensitive detection of glucose for quantitative analysis. By synthetically manipulating of gold NRs and the outer silver shell, the size and aspect ratio of Au@Ag NRs were optimized, and the plasmon resonance wavelength was tuned to approximately the excitation wavelength...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28153193/low-gdp-solution-and-glucose-sparing-strategies-for-peritoneal-dialysis
#9
REVIEW
Cheuk Chun Szeto, David W Johnson
Long-term exposure to a high glucose concentration in conventional peritoneal dialysis (PD) solution has a number of direct and indirect (via glucose degradation products [GDP]) detrimental effects on the peritoneal membrane, as well as systemic metabolism. Glucose- or GDP-sparing strategies often are hypothesized to confer clinical benefits to PD patients. Icodextrin (glucose polymer) solution improves peritoneal ultrafiltration and reduces the risk of fluid overload, but these beneficial effects are probably the result of better fluid removal rather than being glucose sparing...
January 2017: Seminars in Nephrology
https://www.readbyqxmd.com/read/28138003/the-effects-of-liraglutide-in-mice-with-diet-induced-obesity-studied-by-metabolomics
#10
Martina Buganova, Helena Pelantova, Martina Holubova, Blanka Sediva, Lenka Maletinska, Blanka Zelezna, Jaroslav Kunes, Petr Kacer, Marek Kuzma, Martin Haluzik
Liraglutide is the glucagon-like peptide-1 receptor agonist widely used for the treatment of type 2 diabetes mellitus. Recently, it has been demonstrated to decrease cardiovascular morbidity and mortality in patients with type 2 diabetes and high cardiovascular risk. While the major modes of liraglutide action are well-known, its detailed action at the metabolic level has not been studied. To this end, we explored the effect of 2-week liraglutide treatment in C57BL/6 male mice with obesity and diabetes induced by 13 weeks of high-fat diet using NMR spectroscopy to capture the changes in urine metabolic profile induced by the therapy...
January 30, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28125810/insights-from-screening-a-racially-and-ethnically-diverse-population-for-chronic-kidney-disease
#11
Linda L Wong, Kamyar Kalantar-Zadeh, Victoria Page, Glen Hayashida, Amy S You, Connie M Rhee
BACKGROUND: The value of chronic kidney disease (CKD) screening in the general population remains unclear but may be beneficial in populations with high disease prevalence. We examined risk factors for albuminuria among participants in a state-wide CKD screening program in Hawaii. METHODS: The National Kidney Foundation of Hawaii Kidney Early Detection Screening (NKFH-KEDS) program held 19 CKD screening events from 2006 to 2012. Participants rotated through 5 stations during which sociodemographic, blood glucose, urine albumin-to-creatinine ratio (ACR), and spot urine albumin data were collected...
January 27, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28116093/inhibition-of-sglt2-alleviates-diabetic-nephropathy-by-suppressing-high-glucose-induced-oxidative-stress-in-type-1-diabetic-mice
#12
Takashi Hatanaka, Daisuke Ogawa, Hiromi Tachibana, Jun Eguchi, Tatsuyuki Inoue, Hiroshi Yamada, Kohji Takei, Hirofumi Makino, Jun Wada
It is unclear whether the improvement in diabetic nephropathy by sodium glucose cotransporter 2 (SGLT2) inhibitors is caused by a direct effect on SGLT2 or by the improvement in hyperglycemia. Here, we investigated the effect of dapagliflozin on early-stage diabetic nephropathy using a mouse model of type 1 diabetes and murine proximal tubular epithelial cells. Eight-week-old Akita mice were treated with dapagliflozin or insulin for 12 weeks. Body weight, urinary albumin excretion, blood pressure, as well as levels of blood glucose and hemoglobin A1c were measured...
August 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28114247/neuroendocrine-dysfunction-in-a-young-athlete-with-concussion-a-case-report
#13
David M Langelier, Gregory A Kline, Chantel T Debert
An 18-year-old female ringette and basketball player presented to our sport concussion clinic 27 months after concussion with fatigue, headache, exercise intolerance, polyuria, nocturia, and difficulties concentrating. Her history was remarkable for 4 previous concussions. Her neurologic examination was normal. Neuroendocrine screen including thyroid function, morning cortisol, glucose, and insulin-like growth factor-1 (screening test for growth hormone deficiency) were normal. Further testing for growth hormone deficiency with an insulin hypoglycemia test revealed severe growth hormone deficiency...
January 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28101123/regulatory-landscape-of-age-rage-oxidative-stress-axis-and-its-modulation-by-ppar%C3%AE-activation-in-high-fructose-diet-induced-metabolic-syndrome
#14
Luca Cannizzaro, Giuseppe Rossoni, Federica Savi, Alessandra Altomare, Cristina Marinello, Thammakorn Saethang, Marina Carini, D Michael Payne, Trairak Pisitkun, Giancarlo Aldini, Asada Leelahavanichkul
BACKGROUND: The AGE-RAGE-oxidative stress (AROS) axis is involved in the onset and progression of metabolic syndrome induced by a high-fructose diet (HFD). PPARγ activation is known to modulate metabolic syndrome; however a systems-level investigation looking at the protective effects of PPARγ activation as related to the AROS axis has not been performed. The aim of this work is to simultaneously characterize multiple molecular parameters within the AROS axis, using samples taken from different body fluids and tissues of a rat model of HFD-induced metabolic syndrome, in the presence or absence of a PPARγ agonist, Rosiglitazone (RGZ)...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/28095303/gd-dtpa-induced-dynamic-metabonomic-changes-in-rat-biofluids
#15
Chuanling Wan, Youyang Zhan, Rong Xue, Yijie Wu, Xiaojing Li, Fengkui Pei
OBJECTIVES: The purposes of this study were (1) to detect the dynamic metabonomic changes induced by gadopentetate dimeglumine (Gd-DTPA) and (2) to investigate the potential metabolic disturbances associated with the pathogenesis of nephrogenic systemic fibrosis (NSF) at the early stage. METHODS: A nuclear magnetic resonance (NMR)-based metabolomics approach was used to investigate the urinary and serum metabolic changes induced by a single tail vein injection of Gd-DTPA (dosed at 2 and 5mmol/kg body weight) in rats...
January 14, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28074323/changes-in-cerebral-metabolism-during-ketogenic-diet-in-patients-with-primary-brain-tumors-1-h-mrs-study
#16
Moran Artzi, Gilad Liberman, Nachum Vaisman, Felix Bokstein, Faina Vitinshtein, Orna Aizenstein, Dafna Ben Bashat
Normal brain cells depend on glucose metabolism, yet they have the flexibility to switch to the usage of ketone bodies during caloric restriction. In contrast, tumor cells lack genomic and metabolic flexibility and are largely dependent on glucose. Ketogenic-diet (KD) was suggested as a therapeutic option for malignant brain cancer. This study aimed to detect metabolic brain changes in patients with malignant brain gliomas on KD using proton magnetic-resonance-spectroscopy ((1)H-MRS). Fifty MR scans were performed longitudinally in nine patients: four patients with recurrent glioblastoma (GB) treated with KD in addition to bevacizumab; one patient with gliomatosis-cerebri treated with KD only; and four patients with recurrent GB who did not receive KD...
January 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28058588/the-hypoglycemic-hypolipidemic-and-anti-diabetic-nephritic-activities-of-zeaxanthin-in-diet-streptozotocin-induced-diabetic-sprague-dawley-rats
#17
Ling Kou, Mingzhao Du, Chaopu Zhang, Zhiyin Dai, Xuan Li, Baohai Zhang
Zeaxanthin (ZA), an important compound found in Lycium barbarum, shows various pharmacodynamic effects. In our present study, a high-fat, high-sucrose diet and streptozotocin (STZ)-induced diabetic rat model was used to investigate the antidiabetic activities of ZA. After a 4-week administration of 200 and 400 mg/kg of ZA and 100 mg/kg of metformin hydrochloride, various blood biochemical indexes were detected. ZA strongly normalized the reduced bodyweight and enhanced fasting blood glucose in diabetic rats...
January 5, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28046181/increases-in-duodenal-glutamic-acid-supply-linearly-increase-small-intestinal-starch-digestion-but-not-nitrogen-balance-in-cattle
#18
E J Blom, D E Anderson, D W Brake
Small intestinal starch digestion (SISD) in cattle is often limited; however, greater postruminal flow of high-quality protein (e.g., casein) can increase SISD, and Glu can mimic responses to casein for SISD. We evaluated effects of increasing Glu flows to the duodenum on SISD and N retention in cattle. Cattle received (DM basis) continuous duodenal infusion of raw cornstarch (1.5 ± 0.08 kg/d) and 0, 30.9 ± 0.6, 62.4 ± 1.2, or 120.4 ± 3.4 g/d Glu or 387.9 ± 17.5 g/d casein. As expected, the positive control (i...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28012599/blood-oxidative-stress-blos-is-a-secondary-host-defense-system-responding-normally-to-anaerobic-wound-infection-and-inadvertently-to-dietary-ultra-exogenous-sulfide-formation-usf
#19
Peter G Stroot
Blood oxidative stress (BLOS) is the presence of white blood cells and platelets that are generating high levels of reactive oxygen species (ROS). A mathematical model links the level of BLOS or BLOS# and plasma sulfide concentration. An increase in the BLOS# reduces the plasma sulfide concentration. The reported maximum plasma sulfide concentration for defined health conditions were used to calculate the minimum BLOS#. Elevated BLOS generates high plasma concentration of ROS, which triggers multiple responses in the body that protect the host...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28000719/association-between-low-grade-albuminuria-and-frailty-among-community-dwelling-middle-aged-and-older-people-a-cross-sectional-analysis-from-i-lan-longitudinal-aging-study
#20
Chun-Chin Chang, Chien-Yi Hsu, Ting-Yung Chang, Po-Hsun Huang, Li-Kuo Liu, Liang-Kung Chen, Jaw-Wen Chen, Shing-Jong Lin
Frailty is characterized by decreased physiological reserve and increased vulnerability to atherosclerosis and subsequent mortality. Recently, low-grade albuminuria has been proposed as an atherosclerotic risk factor. We aimed to investigate the relationship between low-grade albuminuria and frailty by using cross-sectional data among community-dwelling middle-aged and older people. Totally, 1,441 inhabitants of I-Lan County with normal urinary albumin excretion (urine albumin to urine creatinine ratio [UACR] <30 mg/g) were enrolled (677 men; mean age 63 ± 9 years, range from 50 to 91 years old)...
December 21, 2016: Scientific Reports
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