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https://www.readbyqxmd.com/read/28733522/abi3-a-component-of-the-wave2-complex-is-potentially-regulated-by-pi3k-akt-pathway
#1
Lais Moraes, Nilson I T Zanchin, Janete M Cerutti
We previously reported that ABI3 expression is lost in follicular thyroid carcinomas and its restoration significantly inhibited cell growth, invasiveness, migration, and reduced tumor growth in vivo. The mechanistic basis by which ABI3 exerts its tumor suppressive effects is not fully understood. In this study, we show that ABI3 is a phosphoprotein. Using proteomic array analysis, we showed that ABI3 modulated distinct cancer-related pathways in thyroid cancer cells. The KEA analysis found that PI3K substrates were enriched and forced expression of ABI3 markedly decreased the phosphorylation of AKT and the downstream-targeted protein pGSK3β...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28731531/solitary-splenic-metastasis-from-lung-adenocarcinoma-a-case-report
#2
Kantaro Hara, Nobuhiro Izumi, Takuma Tsukioka, Hiroaki Komatsu, Michihito Toda, Hikaru Miyamoto, Satoshi Suzuki, Takuya Kimura, Toshihiko Shibata, Noritoshi Nishiyama
Solitary splenic metastasis is extremely rare, with only 27 reported cases in the literature. An 81-year-old woman was referred to our hospital for treatment of pulmonary and splenic lesions. Chest computed tomography showed a small lung nodule in the right upper lobe, abdominal computed tomography showed an 8 cm splenic mass with abnormal accumulation, and positron emission tomography revealed a maximum standardized uptake value of 7.9. She had elevated serum cancer antigen 19-9 (1847 U/mL) and carcinoembryonic antigen concentrations (17...
July 21, 2017: Thoracic Cancer
https://www.readbyqxmd.com/read/28726134/non-functioning-parathyroid-carcinoma-a-case-report
#3
Nobuyasu Suganuma, Hiroyuki Iwasaki, Satoru Shimizu, Tatsuya Yoshida, Takashi Yamanaka, Izumi Kojima, Haruhiko Yamazaki, Soji Toda, Hirotaka Nakayama, Katsuhiko Masudo, Yasushi Rino, Kae Kawachi, Yohei Miyagi, Akio Miyake, Kenichi Ohashi, Munetaka Masuda
BACKGROUND: Non-functioning parathyroid carcinoma is a rare disease that is difficult to distinguish from other diseases based on the lack of hyperparathyroidism. This is a report of non-functioning parathyroid carcinoma diagnosed by reverse transcription polymerase chain reaction (RT-PCR) targeting parathyroid hormone (PTH) messenger RNA. CASE PRESENTATION: The patient is a 67-year-old male who visited our hospital for the chief complaint of hoarseness. A 5-cm mass was observed in the right lobe of the thyroid gland, and poorly differentiated thyroid carcinoma was suspected according to the fine-needle biopsy results...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28724570/childhood-thyroid-function-body-composition-and-cardiovascular-function
#4
Mirjana Barjaktarovic, Tim Korevaar, Romy Gaillard, Yolanda B de Rijke, Theo J Visser, Vincent Wv Jaddoe, Robin P Peeters
OBJECTIVE: The cardiovascular system is a known target for thyroid hormone. Early-life cardiovascular alterations may lead to a higher risk of cardiovascular disease in adulthood. Little is known about the effects of thyroid hormone on cardiovascular function during childhood, including the role of body composition in this association. DESIGN: Population-based prospective cohort of children (N=4251, median age 6 years, 95% range 5.7-8.0 years). METHODS: Thyroid stimulating hormone (TSH) and free thyroxine (FT4) concentrations were measured to assess thyroid function...
July 19, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28720678/standardization-of-free-thyroxine-measurements-allows-the-adoption-of-a-more-uniform-reference-interval
#5
Linde A C De Grande, Katleen Van Uytfanghe, Dries Reynders, Barnali Das, James D Faix, Finlay MacKenzie, Brigitte Decallonne, Akira Hishinuma, Bruno Lapauw, Paul Taelman, Paul Van Crombrugge, Annick Van den Bruel, Brigitte Velkeniers, Paul Williams, Linda M Thienpont
BACKGROUND: The IFCC Committee for Standardization of Thyroid Function Tests intended to standardize free thyroxine (FT4) immunoassays. We developed a Système International d'Unités traceable conventional reference measurement procedure (RMP) based on equilibrium dialysis and mass spectrometry. We describe here the latest studies intended to recalibrate against the RMP and supply a proof of concept, which should allow continued standardization efforts. METHODS: We used the RMP to target the standardization and reference interval (RI) panels, which were also measured by 13 manufacturers...
July 18, 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28719612/renal-osteodystrophy-in-the-obesity-era-is-metabolic-syndrome-relevant
#6
Janaina Da Silva Martins, João Henrique Castro, Nestor A Sainz Rueda, Luciene Machado Dos Reis, Vanda Jorgetti, Rosa Maria Affonso Moysés, Jacqueline Teixeira Caramori
BACKGROUND: Observational studies have shown a beneficial effect of obesity on bone health; however, most of those studies were not based on bone biopsies. Metabolic syndrome (MetS) could have an effect on bone remodeling. However, there are no data on the effects of MetS in the presence of renal osteodystrophy. OBJECTIVE: The aim of this study was to investigate associations between MetS and renal osteodystrophy using the bone histomorphometric turnover-mineralization-volume (TMV) classification...
2017: PloS One
https://www.readbyqxmd.com/read/28717364/serum-free-thyroxine-levels-were-associated-with-pulmonary-hypertension-and-pulmonary-artery-systolic-pressure-in-euthyroid-patients-with-coronary-artery-disease
#7
Bingjie Wu, Jingjing Jiang, Minghui Gui, Lin Liu, Qiqige Aleteng, Shanshan Wang, Xiaojing Liu, Yan Ling, Xin Gao
The aim of this study was to evaluate the association between thyroid hormone levels, pulmonary hypertension (PH), and pulmonary artery systolic pressure (PASP) in euthyroid patients with coronary artery disease (CAD). A cross-sectional study was conducted in individuals who underwent coronary angiography and were diagnosed as CAD from March 2013 to November 2013. 811 subjects (185 women and 626 men) were included in this study. PASP was measured by transthoracic Doppler echocardiography. 86 patients were diagnosed as PH and had significantly higher free thyroxine (FT4) levels than those without PH...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28713695/robotic-modified-radical-neck-dissection-with-bilateral-axillo-breast-approach
#8
REVIEW
June Young Choi, Kyung Ho Kang
Bilateral axillo-breast approach (BABA) robotic thyroidectomy has been performed since 2008, and the indications of the BABA robotic operation has been widened to the robotic modified radical neck dissection (MRND). The indication for BABA robotic MRND is suspicious lateral neck metastasis of well-differentiated thyroid carcinoma, and the contraindication is far advanced carcinoma such as encasement of common carotid artery. Surgical procedures start from flap formation as a routine BABA robotic thyroidectomy and the lateral neck dissection is performed from level IV and Vb to level III and IIA...
June 2017: Gland Surgery
https://www.readbyqxmd.com/read/28709933/identification-of-novel-biomarker-and-therapeutic-target-candidates-for-diagnosis-and-treatment-of-follicular-carcinoma
#9
Xianyin Lai, Christopher B Umbricht, Kurt Fisher, Justin Bishop, Qiuying Shi, Shaoxiong Chen
Distinguishing follicular carcinoma from follicular adenoma, based on cytomorphological features, has always been challenging to cytopathologists. Identification of biomarkers for improving diagnostic accuracy is important for clinical management. Meanwhile, it is critical to identify therapeutic target candidates for treatment of follicular carcinoma. Currently, no reliable diagnostic protein biomarkers and therapeutic targets are available. To explore novel protein biomarker and therapeutic target candidates, a liquid chromatography-tandem mass spectrometry approach was applied to analyze control, follicular adenoma, and follicular carcinoma using formalin-fixed, paraffin-embedded tissue samples...
July 11, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28705849/anaplastic-carcinoma-of-thyroid-gland-with-widespread-soft-tissue-metastasis-an-unusual-presentation
#10
Muhammad Hassan, Taimoor Khalid Janjua, Hira Khan Afridi, Naila Anjum Zahid
Anaplastic thyroid cancer is the rarest tumour of the thyroid gland, representing only 2% of clinically recognised thyroid cancers. The most common metastatic sites are lungs, followed by the intrathoracic and neck lymph nodes. We report the case of a 62-year-old woman who presented to our setting with multiple soft tissue nodules, thyroid mass, head swelling and weight loss. Radiological investigation showed a large thyroid mass with widespread metastasis in subcutaneous tissues of both upper limbs, chest and abdomen...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28705700/incidental-primary-intradural-carcinoid-tumor-in-a-patient-with-lumbar-radiculopathy
#11
Stavros Koustais, Philip O'Halloran, Alfrazdaq Hassan, Francesca Brett, Steven Young
BACKGROUND: Carcinoid tumors are neuroendocrine neoplasms derived from enterochromaffin cells. Central nervous system involvement is rare. The reported cases include metastases to brain or spinal cord, as well as primary skeletal or extradural disease resulting in compressive myelo-radiculopathy. There are two previously reported cases of primary intradural extramedullary carcinoid tumor, presenting with compressive symptoms. We report the first case of primary incidental intradural extramedullary carcinoid tumor...
July 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28702266/papillary-thyroid-carcinoma-ectopic-malignancy-versus-metastatic-disease
#12
Yanery's Agosto-Vargas, Madeleine Gutiérrez, José Hernán Martínez, Michelle Mangual-Garcia, Coromoto Palermo, Sharon Vélez-Maymi, Luis Hernández-Vázquez, Samayra Miranda-Rodríguez, Alex González-Bossolo, Ernesto Solá-Sánchez, Marianne Hernández-Negrón
Papillary thyroid carcinoma frequently metastasizes to regional lymph nodes. However, cervical lymph node metastasis as a sole manifestation of occult papillary thyroid carcinoma is rarely observed. Ectopic thyroid is an uncommon condition defined as the presence of thyroid tissue at a site other than pretracheal area. Approximately 1-3% of all ectopic thyroid tissue is located in the lateral neck. This entity may represent the only functional thyroid tissue in the body. Malignant transformation of ectopic thyroid is uncommon; but even rarer is the development of papillary carcinoma on it...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28701285/association-of-divalent-cations-and-insulin-resistance-with-thyroid-hormones-in-patients-with-type-2-diabetes-mellitus
#13
Rajendran Jayanthi, Abu Raghavan Srinivasan, Niranjan Gopal, Ramesh Ramaswamy
AIM: The study was primarily aimed at investigating the association of Magnesium and Zinc levels in the serum of adult Non- obese and Obese type 2 diabetic patients, with particular reference to thyroid comorbidity. METHODS: 108 patients with T2DM of both genders (24 Non obese and 84 Obese) were enrolled from a tertiary health care unit in Puducherry. The cardio-metabolic risk factors were assessed through body mass index, Waist hip ratio, blood pressure, fasting blood glucose, lipid profile and glycated haemoglobin...
July 3, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28699306/strategies-for-building-a-successful-ultrasound-guided-fna-practice-in-department-of-pathology-experience-at-a-university-hospital
#14
Maoxin Wu, Kenneth R Shroyer
INTRODUCTION: Although pathology services focused on fine needle aspiration (FNA) biopsy of superficial palpable masses with on-site cytological evaluation are available in a wide range of clinical and academic settings, the addition of ultrasound (US) guidance into FNA practice by a cytopathologist group can be challenging. An US-FNA service provided by a cytopathologist in the department of Pathology is a relatively new practice in the field of medicine. This report summarizes our experience and strategies in achieving this objective and our successful preliminary results...
July 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28696174/bilateral-lateral-ventricular-subependymoma-with-extensive-multiplicity-presenting-with-hemorrhage
#15
F M Moinuddin, Novita Ikbar Khairunnisa, Hirofumi Hirano, Tomoko Hanada, Tsubasa Hiraki, Mari Kirishima, Kiyohisa Kamimura, Kazunori Arita
This 48-year-old-man who had undergone right thyroid lobectomy for undifferentiated thyroid carcinoma nine years earlier developed generalized seizures. His cerebrospinal fluid was xanthochromic with elevation of total protein. Computed tomography (CT) showed mixed-density bilateral ventricular masses. Magnetic resonance imaging (MRI) revealed multiple nodules in both lateral ventricles; they were heterogeneously enhanced by gadolinium. Diffuse hyperintensity in the right medial temporal lobe and bilateral subependymal area was noted on fluid-attenuated inversion recovery images...
January 1, 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28694837/metastatic-neoplasms-to-the-thyroid-diagnosed-by-fine-needle-aspiration-core-needle-biopsy-clinicopathologic-and-cytomorphologic-correlation
#16
Mobeen Rahman, Ashley Rae Okada, Kevin Guan, Pamela Tauchi-Nishi
BACKGROUND: Although thyroid fine-needle aspiration (FNA) and core needle biopsy (CNB) are commonly utilized modalities in the evaluation of thyroid nodules, metastatic tumors to the thyroid are only rarely encountered. We aspired to determine the incidence and primary origin of metastases to the thyroid at our institution and to examine their clinicopathologic and cytomorphologic features. MATERIALS AND METHODS: A search of our database was undertaken to review all thyroid FNA and/or CNB examined between January 2004 and December 2013...
2017: CytoJournal
https://www.readbyqxmd.com/read/28694701/high-levels-of-nesfatin-1-in-relation-to-the-dysfunction-of-the-hypothalamic-pituitary-adrenal-and-hypothalamus-pituitary-thyroid-axes-in-depressed-patients-with-subclinical-hypothyroidism
#17
Ya-Yun Xu, Jun Liang, Yin Cao, Feng Shan, Yang Liu, Qing-Rong Xia
Despite the increasing amount of evidence suggesting a relationship between depression and subclinical hypothyroidism (SCH), the exact mechanism underlying this relationship remains unclear. The main purpose of this study was to investigate the roles of plasma Nesfatin-1 levels and dysfunction of the hypothalamic-pituitary-adrenal (HPA) and hypothalamus-pituitary-thyroid (HPT) axes in the comorbidity of depression and SCH. Dysfunctions of the HPA and HPT axes were detected by measuring plasma corticosterone and thyroid-stimulating hormone (TSH) concentrations, respectively...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28693723/determination-of-formylated-dna-and-rna-by-chemical-labeling-combined-with-mass-spectrometry-analysis
#18
Han-Peng Jiang, Ting Liu, Ning Guo, Lei Yu, Bi-Feng Yuan, Yu-Qi Feng
Nucleic acids carry diverse chemical modifications that exert critical influences in a variety of cellular processes in living organisms. In addition to methylation, the emerging DNA and RNA formylation has been reported to play functional roles in various physiological processes. However, the amounts of formylated DNA and RNA are extremely low and detection of DNA and RNA formylation is therefore a challenging task. To address this issue, we developed a strategy by chemical labeling combined with in-tube solid-phase microextraction - ultra high performance liquid chromatography - electrospray ionization - tandem mass spectrometry (in-tube SPME-UPLC-ESI-MS/MS) analysis for the sensitive determination of DNA and RNA formylation...
August 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28693115/assessment-of-insulin-like-growth-factor-1-and-igf-binding-protein-3-in-healthy-indian-girls-from-delhi-and-their-correlation-with-age-pubertal-status-obesity-and-thyroid-hormonal-status
#19
Raman K Marwaha, M K Garg, Sushil Gupta, A K Khurana, Archna Narang, Manoj Shukla, Preeti Arora, Aditi Chadha, Deb Datta Nayak, R K Manchanda
BACKGROUND: Population specific data and influence of sub-clinical hypothyroidism on insulin like growth factor-1 (IGF-1) and its binding protein-3 (IGFBP-3) in Indian children is lacking. This study was undertaken to evaluate serum IGF-1 and IGFBP-3 and their correlation with age, gender, pubertal status and thyroid functions. METHODS: A total of 840 apparently healthy school girls aged 6-18 years, were recruited for the study and underwent assessment of height, weight, body mass index, pubertal status and serum T3, T4, TSH, IGF-1, IGFBP-3 and IGF-1/IGFBP-3 molar ratio...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28691976/distinct-lipoprotein-curves-in-normal-weight-overweight-and-obese-children-and-adolescents
#20
Hagar Interator, Yael Lebenthal, Moshe Hoshen, Inbar Safra, Ran Balicer, Moshe Leshno, Raanan Shamir
OBJECTIVES: Pediatric lipoprotein curves are based on population-based samples. As obesity, may alter lipoprotein levels, cut-offs not adjusted for body mass index (BMI) are potentially inappropriate. We aimed to develop distinct serum lipid curves based on sex and BMI-percentiles for children and adolescents. METHODS: Cross-sectional analysis included all healthy children and adolescents (age range 2-17 years) with available serum lipid concentrations (n = 152,820 of approximately 1...
July 6, 2017: Journal of Pediatric Gastroenterology and Nutrition
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