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https://www.readbyqxmd.com/read/29245173/patient-perception-of-disease-related-symptoms-and-complications-in-relapsing-polychondritis
#1
Marcela A Ferrada, Peter C Grayson, Shubhasree Banerjee, Keith Sikora, Robert Colbert, Ninet Sinaii, James D Katz
OBJECTIVE: To assess patient-reported symptoms and burden of disease in relapsing polychondritis (RP). METHODS: Patients with RP completed a disease-specific online survey to identify symptoms attributed to illness. Patients were divided into subgroups based upon presence or absence of ear/nose, airway, or joint involvement. Pathway to diagnosis, treatment, and disease-related complications were assessed within each subgroup. RESULTS: Data from 304 respondents were included in this analysis...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245040/characterising-the-online-weapons-trafficking-on-cryptomarkets
#2
Damien Rhumorbarbe, Denis Werner, Quentin Gilliéron, Ludovic Staehli, Julian Broséus, Quentin Rossy
Weapons related webpages from nine cryptomarkets were manually duplicated in February 2016. Information about the listings (i.e. sales proposals) and vendors' profiles were extracted to draw an overview of the actual online trafficking of weapons. Relationships between vendors were also inferred through the analysis of online digital traces and content similarities. Weapons trafficking is mainly concentrated on two major cryptomarkets. Besides, it accounts for a very small proportion of the illicit trafficking on cryptomarkets compared to the illicit drugs trafficking...
December 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29245021/google-and-suicides-what-can-we-learn-about-the-use-of-internet-to-prevent-suicides
#3
V Chandler
OBJECTIVES: This article studies the statistical relationship between the search propensity of suicide-related terms on Google and the number of suicides. STUDY DESIGN: Suicide mortality data from all American states from January 2006 to November 2014 (n = 5372) and data on Google search intensity for the same period was collected. METHODS: Regression analysis with dynamic components was performed to determine the relationship between search intensity and the number of suicides...
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29244902/feasibility-of-predicting-tumor-motion-using-online-data-acquired-during-treatment-and-a-generalized-neural-network-optimized-with-offline-patient-tumor-trajectories
#4
Troy Teo, Syed Bilal Ahmed, Nadia Alayoubi, Neil Bruce, Ethan Lyn, Stephen Pistorius
PURPOSE: The accurate prediction of intra-fraction lung tumor motion is required to compensate for system latency in image-guided adaptive radiotherapy systems. The goal of this study was to identify an optimal prediction model that has a short learning period so that prediction and adaptation can commence soon after treatment begins, and requires minimal re-optimization for individual patients. Specifically, the feasibility of predicting tumor position using a combination of a generalized (i...
December 15, 2017: Medical Physics
https://www.readbyqxmd.com/read/29244803/changes-in-brain-morphology-and-microstructure-in-relation-to-early-brain-activity-in-extremely-preterm-infants
#5
Maria Luisa Tataranno, Nathalie H P Claessens, Pim Moeskops, Mona C Toet, Karina J Kersbergen, Giuseppe Buonocore, Ivana Išgum, Alexander Leemans, Serena Counsell, Floris Groenendaal, Linda S de Vries, Manon J N L Benders
OBJECTIVE: To investigate the relation of early brain activity with structural (growth of the cortex and cerebellum) and white matter microstructural brain development. METHODS: 33 preterm neonates (gestational age 26±1 weeks) without major brain abnormalities were continuously monitored with electroencephalography (EEG) during the first 48 h of life. Rate of spontaneous activity transients per minute (SAT rate) and interSAT interval (ISI) in seconds per minute were calculated...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244802/elevations-of-inflammatory-proteins-in-neonatal-blood-are-associated-with-obesity-and-overweight-among-2-year-old-children-born-extremely-premature
#6
Eliana M Perrin, T Michael O'Shea, Asheley Cockrell Skinner, Carl Bose, Elizabeth N Allred, Raina N Fichorova, Jelske W van der Burg, Alan Leviton
BACKGROUND: Childhood obesity is associated with elevated blood concentrations of inflammation markers. It is not known to what extent inflammation precedes the development of obesity. METHODS: In a cohort of 882 infants born before 28 weeks of gestation, we examined relationships between concentrations of 25 inflammation-related proteins in blood obtained during the first two postnatal weeks and body mass index at 2 years of age. RESULTS: Among children delivered for spontaneous indications (n=734), obesity was associated with elevated concentrations of four proteins (IL-1β, IL-6, TNF-R1, and MCP-1) on the first postnatal day; one protein (IL-6) on postnatal day 7; and two proteins (ICAM-3 and VEGF-R1) on postnatal day 14...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244801/hope-vs-caution-ethical-and-regulatory-considerations-for-neonatal-stem-cell-therapies
#7
Naomi Laventhal, Scott Rivkees, Valerie Opipari
Pediatric Research accepted article preview online, 15 December 2017. doi:10.1038/pr.2017.320.
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244800/hla-dq-genetics-in-children-with-celiac-disease-a-meta-analysis-suggesting-a-two-step-genetic-screening-procedure-starting-with-hla-dq-%C3%AE-chains
#8
Annalisa De Silvestri, Cristina Capittini, Dimitri Poddighe, Chiara Valsecchi, Gianluigi Marseglia, Sara Carlotta Tagliacarne, Valeria Scotti, Chiara Rebuffi, Annamaria Pasi, Miryam Martinetti, Carmine Tinelli
OBJECTIVES: through a meta-analysis, evaluating the distribution of the predisposing HLA genotype to Celiac Disease (CD) in children and providing insights for potential widened screening strategy. STUDY DESIGN: After a systematic search on the association between HLA class II and CD in children, 46 publications were obtained and assessed for eligibility. 13 eligible studies were submitted to data extraction and analysis (10 studies case-control and 3 cohort studies)...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244799/prenatal-and-early-postnatal-measures-of-brain-development-and-childhood-sleep-patterns
#9
Desana Kocevska, Maria E Verhoeff, Selma Meinderts, Vincent W Jaddoe, Frank C Verhulst, Sabine J Roza, Maartje P C M Luijk, Henning Tiemeier
BACKGROUND: Brain development underlies maturation of sleep patterns throughout childhood. Intrauterine head growth -marker of early neurodevelopment- has not been associated with childhood sleep characteristics. We explored associations between ultrasonographic measures of prenatal and early postnatal neurodevelopment and childhood sleep. METHODS: Six-thousand-five-hundred-twenty-eight children from a population-based birth cohort (Generation R) were included. Head circumference (HC) and lateral ventricles size were assessed with mid- and late-pregnancy fetal ultrasounds, and with cranial ultrasound 3-20 weeks postnatally...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244798/amplitude-integrated-electroencephalography-during-the-first-72-hours-after-birth-in-neonates-diagnosed-prenatally-with-congenital-heart-disease
#10
Mirthe J Mebius, Nathalie J E Oostdijk, Sara J Kuik, Arend F Bos, Rolf M F Berger, Caterina M Bilardo, Elisabeth M W Kooi, Hendrik J Ter Horst
BACKGROUND: Little is known on amplitude-integrated electroencephalography (aEEG) during the first days after birth in neonates with CHD. Our aim was, therefore, to assess electro-cortical activity using aEEG within the first 72 h after birth in neonates diagnosed prenatally with CHD, and to define independent prenatal and postnatal predictors for abnormal aEEG. METHODS: Neonates with CHD that were admitted to the neonatal intensive care unit between 2010 and 2017 were retrospectively included...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244797/association-between-maternal-hypothyroidism-and-autism-spectrum-disorders-in-the-children
#11
Darios Getahun, Steven J Jacobsen, Michael J Fassett, Deborah A Wing, Anny H Xiang, Vicki Chiu, Morgan R Peltier
OBJECTIVE: To determine if hypothyroidism is associated with ASD and how this association is influenced by race-ethnicity, sex, and timing of exposure. METHODS: A retrospective cohort study was conducted using records from 397201 children who were delivered from 1991-2011 and remained health plan members from 1993-2014. RESULTS: Children of hypothyroid women had higher ASD rates than children of women without the diagnosis (2.14 vs. 1.62/1000 person-years; and adjusted hazard ratios [adj...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244796/rsv-bronchiolitis-versus-rhinovirus-difference-in-nasal-airway-microrna-profiles-and-nf%C3%AE%C2%BAb-signaling
#12
Kohei Hasegawa, Marcos Pérez-Losada, Claire E Hoptay, Samuel Epstein, Jonathan M Mansbach, Stephen J Teach, Pedro A Piedra, Carlos A Camargo, Robert J Freishtat
BACKGROUND: Although rhinovirus infection is associated with increased risks of acute and chronic respiratory outcomes during childhood compared with respiratory syncytial virus (RSV), the underlying mechanisms remain unclear. We aimed to determine differences in nasal airway microRNA profiles and their downstream effects between infants with rhinovirus and RSV bronchiolitis. METHODS: As part of multicenter cohort study of infants hospitalized for bronchiolitis, we examined nasal samples obtained from 16 infants with rhinovirus and 16 infants with RSV...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244795/jack-widness-the-importance-of-connections
#13
Steven J McElroy
Pediatric Research accepted article preview online, 15 December 2017. doi:10.1038/pr.2017.317.
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244794/health-implications-of-dietary-habits-in-transition-countries-a-life-course-perspective
#14
Carlo Agostoni, Marco Silano, Giovanni Fattore
Pediatric Research accepted article preview online, 15 December 2017. doi:10.1038/pr.2017.319.
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244793/effects-of-epinephrine-on-hemodynamic-changes-during-cardiopulmonary-resuscitation-in-a-neonatal-piglet-model
#15
Michael Wagner, Po-Yin Cheung, Elliott S Li, Tze-Fun Lee, Min Lu, Megan O'Reilly, Monika Olischar, Georg M Schmölzer
BACKGROUND: Asphyxia is the most common reason for newborns to fail to make a successful fetal to neonatal transition. There is currently a lack of data evaluating hemodynamic effects of epinephrine during neonatal cardiopulmonary resuscitation. METHODS: Twenty-four newborn piglets were exposed to asphyxia. Thereafter, positive pressure ventilation was commenced for 30 s, followed by chest compressions (CC). Piglets were randomized into three experimental groups: 3:1 compression:ventilation ratio; CC during sustained inflation (SI) at a rate of 90 CC per minute, or CC during SI at a rate of 120 CC per minute...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244792/tight-glycemic-control-in-critically-ill-pediatric-patients-a-meta-analysis-and-systematic-review-of-randomized-controlled-trials
#16
Yiyang Zhao, Yang Wu, Bo Xiang
BACKGROUND: There still are controversies in the impact of tight glycemic control (TGC) in critically ill children. The aim of this study was to assess the benefits and risks of TGC compared with conventional glycemic control (CGC) in critically ill pediatric patients admitted to the pediatric intensive care unit (PICU) by using data retrieved from randomized controlled trials (RCTs). METHOD: EMBASE, CNKI, PubMed and the Cochrane Database were searched for RCTs comparing TGC with CGC in critically ill children in PICU...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244791/management-and-outcomes-of-childhood-goodpasture-s-disease
#17
Carmela P Menzi, Barbara S Bucher, Mario G Bianchetti, Gianluigi Ardissino, Giacomo D Simonetti
BACKGROUND: In an attempt to improve knowledge about childhood Goodpasture's disease, we performed a retrospective analysis of patients with Goodpasture's disease from several pediatric nephrology centers. METHODS: We analyzed the responses to 27 questions that elicited information about the following: incidence, demographics, patient history and clinical presentation, diagnostics performed, acute and chronic therapy, course of disease and outcome. RESULTS: Goodpasture's disease, which is extremely rare in this age group, may manifest in 2-year-old toddlers and does not typically present with pulmonary findings before puberty...
December 15, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29244723/an-online-mfl-sensing-method-for-steel-pipe-based-on-the-magnetic-guiding-effect
#18
Jianbo Wu, Hui Fang, Xiaoming Huang, Hui Xia, Yihua Kang, Chaoqing Tang
In order to improve the sensitivity of online magnetic flux leakage (MFL) testing for steel pipe, a sensing method based on the magnetic guiding effect is proposed and investigated in this paper. Compared to the conventional contact sensing method using a non-ferromagnetic support, the proposed method creatively utilizes a ferromagnetic one to guide more magnetic flux to leak out. Based on Hopkinson's law, the principle of the magnetic guiding effect of the ferromagnetic support is theoretically illustrated...
December 15, 2017: Sensors
https://www.readbyqxmd.com/read/29244632/delivery-of-global-cancer-care-an-international-study-of-medical-oncology-workload
#19
Adam Fundytus, Richard Sullivan, Verna Vanderpuye, Bostjan Seruga, Gilberto Lopes, Nazik Hammad, Manju Sengar, Wilma M Hopman, Michael D Brundage, Christopher M Booth
Background To our knowledge, there is no literature that has described medical oncology (MO) workload in the global context. Here, we report results of an international study of global MO workload. Methods An online survey was distributed through a snowball method via national oncology societies to chemotherapy-prescribing physicians in 65 countries. Countries were classified into low- or low-middle-income countries (LMICs), upper-middle-income countries (UMICs), and high-income countries (HICs) on the basis of World Bank criteria...
December 15, 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/29244617/differentiation-of-high-grade-from-low-grade-astrocytoma-improvement-in-diagnostic-accuracy-and-reliability-of-pharmacokinetic-parameters-from-dce-mr-imaging-by-using-arterial-input-functions-obtained-from-dsc-mr-imaging
#20
Sung-Hye You, Seung Hong Choi, Tae Min Kim, Chul-Kee Park, Sung-Hye Park, Jae-Kyung Won, Il Han Kim, Soon Tae Lee, Hye Jeong Choi, Roh-Eul Yoo, Koung Mi Kang, Tae Jin Yun, Ji-Hoon Kim, Chul-Ho Sohn
Purpose To evaluate whether arterial input functions (AIFs) derived from dynamic susceptibility-contrast (DSC) magnetic resonance (MR) imaging, or AIFDSC values, improve diagnostic accuracy and reliability of the pharmacokinetic (PK) parameters of dynamic contrast material-enhanced (DCE) MR imaging for differentiating high-grade from low-grade astrocytomas, compared with AIFs obtained from DCE MR imaging (AIFDCE). Materials and Methods This retrospective study included 226 patients (138 men, 88 women; mean age, 52...
December 15, 2017: Radiology
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