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https://www.readbyqxmd.com/read/28444102/pet-mri-a-novel-hybrid-imaging-technique-major-clinical-indications-and-preliminary-experience-in-brazil
#1
Taise Vitor, Karine Minaif Martins, Tudor Mihai Ionescu, Marcelo Livorsi da Cunha, Ronaldo Hueb Baroni, Marcio Ricardo Taveira Garcia, Jairo Wagner, Guilherme de Carvalho Campos, Solange Amorim Nogueira, Elaine Gonçalves Guerra, Edson Amaro
In recent years, medical imaging with hybrid techniques has widely accepted and employed in clinical routine. PET/MRI offers significant advantages, including excellent contrast and resolution and reduced ionizing radiation, as compared to well-established PET/CT. Therefore, PET/MRI is a promising modality for oncologic imaging of some regions, such as brain, head and neck, liver and pelvis. This article set out to analyze clinical conditions that could benefit from PET/MRI imaging based on our caseload. The potential of PET/MRI to become the imaging modality of choice for assessment of neurologic and oncologic conditions associated with soft tissues is highlighted...
January 2017: Einstein
https://www.readbyqxmd.com/read/28443931/the-effect-of-temperature-composition-and-alcohols-on-the-microstructures-of-catanionic-mixtures-of-sodium-dodecylsulfate-and-cetyltrimethylammonium-bromide-in-water
#2
S Rajkhowa, S Mahiuddin, J Dey, S Kumar, V K Aswal, R Biswas, J Kohlbrecher, K Ismail
The influence of mixing protocol, composition, temperature, ageing and added alcohols on the characteristics of the microstructures of sodium dodecylsulfate (SDS) + cetyltrimethylammonium bromide (CTAB) mixtures has been investigated in this paper. In this catanionic mixture (1 weight% total surfactant content) temperature induced microstructural transition occurs, which is (i) a micelle-to-vesicle transition (MVT) if αSDS (mole fraction of SDS) = 0.7, 0.8 or 0.9 and (ii) a vesicle-to-micelle transition (VMT) if αSDS = 0...
April 26, 2017: Soft Matter
https://www.readbyqxmd.com/read/28443862/a-small-bandgap-semiconductor-p-type-mnv2o6-active-for-photocatalytic-hydrogen-and-oxygen-production
#3
Brandon Zoellner, Elijah Gordon, Paul A Maggard
Extensive research has been conducted with the goal to find a single bandgap material that can absorb visible light and efficiently drive the catalysis of water to both hydrogen and oxygen. The p-type MnV2O6 (C2/m, Z = 2, a = 9.289 Å, b = 3.535 Å, and c = 6.763 Å, β = 112.64°), synthesized via solid-state techniques, was investigated for its potential use in the visible-light photocatalysis of water. Mott-Schottky analysis was used to experimentally determine the energetic positions of the valence and conduction bands as +0...
April 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28442628/papers-of-note-in-science356-6335
#4
Annalisa M VanHook
This week's articles highlight a peptide that controls myoblast fusion; a metabolic adaptation that enables naked mole-rats to resist the detrimental effects of anoxia; a transcription factor that coordinates signaling in the mammary epithelial stem cell niche; and transgenerational epigenetic inheritance of the response to an environmental stimulus.
April 25, 2017: Science Signaling
https://www.readbyqxmd.com/read/28440618/design-of-antibacterial-polyethersulfone-membranes-via-covalently-attaching-hydrogel-thin-layers-loaded-with-ag-nanoparticles
#5
Min He, Qian Wang, Rui Wang, Yi Xie, Weifeng Zhao, Changsheng Zhao
In order to inhibit the bacteria attachment and the subsequent formation of bio-films on polyethersulfone (PES) membranes, poly(sulfobetaine methacrylate) (PSBMA)/poly(sodium acrylate) (PAANa) antibacterial hydrogel thin layers were covalently attached onto the membranes, followed by loading Ag nanoparticles. In our strategy, double bonds were firstly introduced onto PES membrane surfaces to provide anchoring sites, and then the hydrogel layers were synthesized on the membrane surfaces via UV light initiated cross-linking copolymerization...
April 25, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28436027/production-and-characterization-of-active-recombinant-human-factor-ii-with-consistent-sialylation
#6
Jeong H Lee, Jason Reier, Kelley M Heffner, Christopher Barton, David Spencer, Albert E Schmelzer, Raghavan Venkat
Coagulation factor II (prothrombin; FII) is the pre-proteolyzed precursor to thrombin in the coagulation cascade. It has ten sites of gamma-carboxylation, which are required for its bioactivity, and is N-glycosylated at three of four putative sites. Production of recombinant human FII (rhFII) using a platform fed-batch process designed for monoclonal antibody production resulted in low levels of gamma-carboxylation and sialylation. There have not been any prior reports of successful process development and clinical manufacture of rhFII with optimal, consistent gamma-carboxylation and sialylation...
April 24, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28433900/production-of-new-human-milk-fat-substitutes-by-enzymatic-acidolysis-of-microalgae-oils-from-nannochloropsis-oculata-and-isochrysis-galbana
#7
Yongjin He, Changyang Qiu, Zheng Guo, Jian Huang, Mingzi Wang, Bilian Chen
Human milk fat substitutes (HMFs) with four kinds of n-3 fatty acid for infant formula were firstly synthesized using triacylglycerols (TAGs) from Nannochloropsis oculata rich in PA at the sn-2 position and free fatty acids (FFAs) from Isochrysis galbana rich in n-3 polyunsaturated fatty acids (n-3 PUFAs-ALA/SDA/DHA) via solvent-free acidolysis with Novozym 435, Lipozyme 435, TL-IM and RM-IM as biocatalysts. The results show that the resulting HMFs contain total n-3 PUFA of 13.92-17.12% and PA of 59.38-68.13% at the sn-2 position under the optimal conditions (mole ratio FFAs/TAG 3:1, 60°C (Novozym 435 and Lipozyme TL-IM) and 50°C (Lipozyme 435 and RM-IM), lipase loading 10%, reaction time 24h)...
April 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28433040/predicting-miscibility-of-binary-liquids-from-small-cluster-qce-calculations
#8
Johannes Ingenmey, Michael von Domaros, Barbara Kirchner
The quantum cluster equilibrium method is applied to model binary systems of molecular solvents. We minimize the computational effort as well as the experimental input and present the results obtained for the completely miscible acetonitrile/acetone, benzene/acetone, and water/acetone systems, as well as for the hardly miscible water/benzene system. Only clusters of sizes up to n = 3 are applied and these are optimized employing the low-cost functional PBEh-3c. The thermodynamic functions of the pure liquids are in reasonable agreement with experiments...
April 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28428943/pathogenic-variant-in-nlrp7-19q13-42-associated-with-recurrent-gestational-trophoblastic-disease-data-from-early-embryo-development-observed-during-in-vitro-fertilization
#9
E Scott Sills, Alexandra J Obregon-Tito, Harry Gao, Thomas K McWilliams, Anthony T Gordon, Catharine A Adams, Rima Slim
OBJECTIVE: To describe in vitro development of human embryos derived from an individual with a homozygous pathogenic variant in NLRP7 (19q13.42) and recurrent hydatidiform mole (HM), an autosomal recessive condition thought to occur secondary to an oocyte defect. METHODS: A patient with five consecutive HM pregnancies was genomically evaluated via next generation sequencing followed by controlled ovarian hyperstimulation, in vitro fertilization (IVF) with intracytoplasmic sperm injection, embryo culture, and preimplantation genetic screening...
March 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28428423/fructose-driven-glycolysis-supports-anoxia-resistance-in-the-naked-mole-rat
#10
Thomas J Park, Jane Reznick, Bethany L Peterson, Gregory Blass, Damir Omerbašić, Nigel C Bennett, P Henning J L Kuich, Christin Zasada, Brigitte M Browe, Wiebke Hamann, Daniel T Applegate, Michael H Radke, Tetiana Kosten, Heike Lutermann, Victoria Gavaghan, Ole Eigenbrod, Valérie Bégay, Vince G Amoroso, Vidya Govind, Richard D Minshall, Ewan St J Smith, John Larson, Michael Gotthardt, Stefan Kempa, Gary R Lewin
The African naked mole-rat's (Heterocephalus glaber) social and subterranean lifestyle generates a hypoxic niche. Under experimental conditions, naked mole-rats tolerate hours of extreme hypoxia and survive 18 minutes of total oxygen deprivation (anoxia) without apparent injury. During anoxia, the naked mole-rat switches to anaerobic metabolism fueled by fructose, which is actively accumulated and metabolized to lactate in the brain. Global expression of the GLUT5 fructose transporter and high levels of ketohexokinase were identified as molecular signatures of fructose metabolism...
April 21, 2017: Science
https://www.readbyqxmd.com/read/28428421/low-temperature-activation-of-methane-on-the-iro2-110-surface
#11
Zhu Liang, Tao Li, Minkyu Kim, Aravind Asthagiri, Jason F Weaver
Methane undergoes highly facile C-H bond cleavage on the stoichiometric IrO2(110) surface. From temperature-programmed reaction spectroscopy experiments, we found that methane molecularly adsorbed as a strongly bound σ complex on IrO2(110) and that a large fraction of the adsorbed complexes underwent C-H bond cleavage at temperatures as low as 150 kelvin (K). The initial dissociation probability of methane on IrO2(110) decreased from 80 to 20% with increasing surface temperature from 175 to 300 K. We estimate that the activation energy for methane C-H bond cleavage is 9...
April 21, 2017: Science
https://www.readbyqxmd.com/read/28426257/facial-eschar-following-a-single-application-of-black-salve
#12
Dayne Laskey, Midori Tran
A previously healthy 86-year-old male was transported by ambulance to the trauma bay of the emergency department (ED) for profuse bleeding from the left temple. The ambulance crew raised concern that the volume and force of the bleed may suggest arterial involvement. The patient reported having applied a natural topical remedy to a mole two weeks prior at the recommendation of a naturopath. The patient described progressive blackening and swelling of the area in the days following the single application of the product...
April 20, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28425710/solvation-structure-of-1-3-butanediol-in-aqueous-binary-solvents-with-acetonitrile-1-4-dioxane-and-dimethyl-sulfoxide-studied-by-ir-nmr-and-molecular-dynamics-simulation
#13
Toshiyuki Takamuku, Yasuhito Higuma, Masaru Matsugami, Takahiro To, Tatsuya Umecky
The solvation structure of 1,3-butanediol (1,3-BD) in aqueous binary solvents of acetonitrile (AN), 1,4-dioxane (DIO), and dimethyl sulfoxide (DMSO) at various mole fractions of organic solvent xOS has been clarified by means of infrared (IR) and (1)H and (13)C NMR. The change in the wavenumber of O-H stretching vibration of 1,3-BD in the three systems suggested that water molecules which are initially hydrogen-bonded with the 1,3-BD hydroxyl groups in the water solvent (xOS = 0) are more significantly replaced by organic solvent molecules in the order of DMSO ≫ DIO > AN...
April 26, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28425035/a-new-ascaridid-nematode-mammalakis-zambiensis-n-sp-heterakoidea-kiwinematidae-from-the-mole-rat-fukomys-anselli-burda-zima-scharff-machol%C3%A3-n-kawalika-rodentia-bathyergidae-in-zambia
#14
Kerstin Junker, Heike Lutermann, Yasen Mutafchiev
Mammalakis zambiensis n. sp. is described from the large intestine and caecum of Fukomys anselli (Burda, Zima, Scharff, Macholán & Kawalika), a bathyergid rodent endemic to Zambia. Morphological data for comparison with its three congeners, M. macrospiculum (Ortlepp, 1939), M. spalacis (Marcu, 1930) and M. spalaxi (Kozlov & Jangolenko, 1962) are provided. Based on studies of the type-material, observations of hitherto undescribed morphological characters of M. macrospiculum, a parasite of Bathyergus suillus (Schreber) (Hystricomorpha: Bathyergidae) in South Africa, are presented...
April 19, 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28420522/successful-treatment-of-gestational-trophoblastic-neoplasia-in-the-uterine-cornus-with-laparoscopic-cornuostomy-and-postoperative-methotrexate-injection
#15
Pei-Ling Chen, Jie-Yang Jhuang, Ho-Hsiung Lin, Sheng-Mou Hsiao
OBJECTIVE: Management of cornual gestational trophoblastic neoplasia (GTN) has never been reported. Here, we describe the first case of cornual GTN. CASE REPORT: A 32-year-old woman was diagnosed with left cornual GTN after evacuation of a complete mole. Laparoscopic cornuostomy was performed with intramural vasopression injection and barbed sutures. Histopathology revealed hydropic chorionic villi. Complete hydatidiform mole was diagnosed, and treated with adjuvant methotrexate, to address the poor decline of β-human chorionic gonadotropin levels during follow-up...
April 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28414339/coherent-anti-stokes-raman-spectroscopy-measurement-of-ethylene-in-combustion
#16
Andrew D Cutler, Emanuela C A Gallo, Luca M L Cantu
Width-increased dual-pump enhanced coherent anti-Stokes Raman spectroscopy (WIDECARS) has been developed for spatially and temporally resolved simultaneous measurement of temperature and mole fraction of most major species in ethylene-air flames. This paper describes a method to infer coherent anti-Stokes Raman spectroscopy complex susceptibility distributions of the ν<sub>3</sub> band of ethylene from WIDECARS spectra measured in heated mixtures of ethylene and air, and to use such distributions to fit experimental WIDECARS spectra in an ethylene-air flame...
April 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/28412694/the-sting
#17
Mole
No abstract text is available yet for this article.
April 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28411623/hemoptysis-as-primary-manifestation-in-three-women-with-choriocarcinoma-with-pulmonary-metastasis-a-case-series
#18
Wenping Zhang, Bao Liu, Jizhen Wu, Beibei Sun
BACKGROUND: Gestational choriocarcinoma is the most common gestational trophoblastic neoplasia; it is often secondary to hydatidiform mole, as well as to abortion, ectopic pregnancy, premature delivery, or term delivery. Approximately 60% of patients with choriocarcinoma develop pulmonary metastases, but for patients with a respiratory condition, choriocarcinoma with lung metastasis is a relatively rare lung cancer diagnosis. Three cases of choriocarcinoma with pulmonary metastasis who had the primary symptom of hemoptysis are described...
April 16, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28409694/immunohistochemical-localization-of-irisin-in-mole-rats-spalax-leucodon
#19
F M Gür, S Timurkaan, M H Yalcin, A Girgin, B Gençer Tarakçı
Irisin was first identified in skeletal muscle cells. It is an exercise protein that is secreted into the circulation; it causes conversion of white adipose tissue to brown adipose tissue. We investigated irisin immunoreactivity in mole rat (Spalax leucodon) tissues. We examined cerebellum, pituitary, heart, liver, pancreas, spleen, uterus, kidney and striated muscle in female adult mole rats. Tissues were processed, embedded in paraffin, sectioned at 5 μm and stained immunohistochemically for irisin. Irisin immunostaining was detected in the cytoplasm of stained cells; the cytoplasm of Purkinje cells was unstained...
April 14, 2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28407893/h2o2-oxidative-preparation-characterization-and-antiradical-activity-of-a-novel-oligosaccharide-derived-from-flaxseed-gum
#20
Shan Liang, Wenzhen Liao, Xiang Ma, Xiaofeng Li, Yong Wang
In this present study, a novel flaxseed gum oligosaccharide (FGOS) was prepared by H2O2 oxidative degradation method followed by physicochemical properties characterization and antiradical activity evaluation. Results indicated that the degradation rate of flaxseed gum is 37.81% under the optimum conditions (i.e., reaction temperature of 120°C, H2O2 concentration of 0.2M and reaction time of 2.0h) and FGOS as a reddish brown semisolid was obtained. Physicochemical properties identification showed that FGOS has a molecular weight of 1047Da and is a typical oligosaccharide which contains uronic acid...
September 1, 2017: Food Chemistry
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