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David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
Seyed Nezamedin Hosseini, Parisa Ghaisari, Shahram Sharifnia, Maryam Khatami, Amin Javidanbardan
In the downstream process of recombinant hepatitis B surface antigen (rHBsAg), nano-colloidal silica adsorbent (Aerosil-380) is one of the possible methods to separate the antigen from other main impurities partially. The current study aimed to maximize the adsorptive capacity of Aerosil-380 as well as rHBsAg recovery for large-scale production of recombinant hepatitis B vaccine. The experimental design methodology was used to optimize the eight critical parameters influencing the efficiency, rHBsAg recovery, of the adsorption-desorption process in the lab-scale...
June 22, 2018: Preparative Biochemistry & Biotechnology
Jessica Keim-Malpass, Kyle B Enfield, James Forrest Calland, Douglas E Lake, Matthew T Clark
Predictive analytics monitoring that informs clinicians of the risk for failed extubation would help minimize both the duration of mechanical ventilation and the risk of emergency re-intubation in ICU patients. We hypothesized that dynamic monitoring of cardiorespiratory data, vital signs, and lab test results would add information to standard clinical risk factors. To develop predictive analytic models for patients who failed extubation in critical care settings in an academic medical center using standard and novel risk factors...
June 22, 2018: Physiological Measurement
Marie-Ève Daspe, Reout Arbel, Michelle C Ramos, Lauren A S Shapiro, Gayla Margolin
This study examines whether nonverbal displays of parents' warmth during an in-lab conflict discussion mitigate the links between affiliation with deviant peers and risky behaviors. A sample of 107 youth and their parents participated in a study spanning from mid-adolescence (T1) to late adolescence (T2). At T1, family members discussed a contentious issue, which was coded for parents' nonverbal warmth. At T1 and T2, youth reported on their friends' and their own risky behaviors. Fathers' warmth moderated each prospective association between deviant peers and risky behaviors...
June 22, 2018: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
Kolter B Grigsby, Gregory N Ruegsegger, Thomas E Childs, Frank W Booth
A gene was sought that could reverse low voluntary running distances in a model of low voluntary wheel-running behavior. In order to confirm the low motivation to wheel-run in our model does not result from defects in reward valuation, we employed sucrose preference and conditioned place preference for voluntary wheel-access. We observed no differences between our model and wild-type rats regarding the aforementioned behavioral testing. Instead, low voluntary runners seemed to require less running to obtain similar rewards for low voluntary running levels compared to wild-type rats...
June 21, 2018: Molecular Neurobiology
Zhaojuan Zheng, Meijuan Xia, Xuchao Fang, Ting Jiang, Jia Ouyang
Phenyllactic acid (PLA) is a high-value compound, which was usually produced by lactic acid bacteria (LAB) as biocatalysts and glucose or phenylpyruvic acid (PPA) as starting materials for PLA synthesis in previous studies. However, the PLA produced using LAB is a racemic mixture. Besides, both glucose and PPA were unsatisfactory substrates, as the former could not produce high concentrations of PLA while the latter is not a renewable and green substrate. To overcome these drawbacks, in this study, a new biotransformation process was developed for chiral PLA production from L-phenylalanine via the intermediate PPA using recombinant Escherichia coli co-expressing L-amino acid deaminase, NAD-dependent L-lactate dehydrogenase or NAD-dependent D-lactate dehydrogenase, and formate dehydrogenase...
June 22, 2018: Bioprocess and Biosystems Engineering
Yuri S Tokarev, Katy M Peat, Julia M Malysh, Igor V Senderskiy
A microsporidium was found in a Mediterranean cricket Gryllus bimaculatus from a pet market in the UK and a lab stock at the Moscow Zoo (originating from London Zoo). The spores were ovoid, uninucleate, 6.3 × 3.7 μm in size (unfixed), in packets by of 8, 16, or 32. The spores were easily discharged upon dessication or slight mechanical pressure. The polar tube was isofilar, with 15-16 coils arranged in 1-2 rows. The polaroplast was composed of thin lamellae and occupied about one third of the spore volume...
June 21, 2018: Parasitology Research
Jack Hanson, Kuldip Paliwal, Thomas Litfin, Yuedong Yang, Yaoqi Zhou
Motivation: Accurate prediction of a protein contact map depends greatly on capturing as much contextual information as possible from surrounding residues for a target residue pair. Recently, ultra-deep residual convolutional networks were found to be state-of-the-art in the latest Critical Assessment of Structure Prediction techniques (CASP12, (Schaarschmidt et al., 2018)) for protein contact map prediction by attempting to provide a protein-wide context at each residue pair. Recurrent neural networks have seen great success in recent protein residue classification problems due to their ability to propagate information through long protein sequences, especially Long Short-Term Memory (LSTM) cells...
June 19, 2018: Bioinformatics
Florian Erhard
Motivation: Fold changes from count based high-throughput experiments such as RNA-seq suffer from a zero-frequency problem. To circumvent division by zero, so-called pseudocounts are added to make all observed counts strictly positive. The magnitude of pseudocounts for digital expression measurements and on which stage of the analysis they are introduced remained an arbitrary choice. Moreover, in the strict sense, fold changes are not quantities that can be computed. Instead, due to the stochasticity involved in the experiments, they must be estimated by statistical inference...
June 19, 2018: Bioinformatics
Georgy Derevyanko, Sergei Grudinin, Yoshua Bengio, Guillaume Lamoureux
Motivation: The computational prediction of a protein structure from its sequence generally relies on a method to assess the quality of protein models. Most assessment methods rank candidate models using heavily engineered structural features, defined as complex functions of the atomic coordinates. However, very few methods have attempted to learn these features directly from the data. Results: We show that deep convolutional networks can be used to predict the ranking of model structures solely on the basis of their raw three-dimensional atomic densities, without any feature tuning...
June 19, 2018: Bioinformatics
Nicole T Lopez, Sean K McCoy, Christine Carroll, Ellen Jones, Joel A Miller
Background: Two studies by Bledsoe et al and Anand et al reported limited efficacy of the Supraglottic Airway Laryngeal Tube (SALT), which is a supraglottic airway (SGA) specifically designed for blind endotracheal intubation. Miller et al reported a 50% success rate using an Eschmann introducer as an adjunct for blind airway exchange via the laryngeal mask airway (LMA) classic. Another study by Ueki et al found that endotracheal tube (ETT) intubation was faster and less damaging to the airway when the Aintree intubating catheter was used in conjunction with a fiberoptic bronchoscope...
June 19, 2018: Military Medicine
Neeraj Ganju, Sachin Sondhi, Arvind Kandoria
A 45-year-old man without previous comorbidity presented to us with acute onset right-sided flank pain for last 14 hours. His general physical and systemic examination was unremarkable, and there were no clinical signs of peritonitis. The ultrasonography did not reveal any evidence of nephrolithiasis or hydronephrosis. His contrast-enhanced CT scan revealed hypoattenuated areas of right kidney and evidence of right renal artery thrombosis. He was immediately shifted to cardiac catheterisation lab, and his renal angiography showed thrombotic occlusion of right renal artery...
June 21, 2018: BMJ Case Reports
Melody Allensworth-James, Angela Odle, Anessa Haney, Melanie MacNicol, Angus MacNicol, Gwen V Childs
The developing pituitary is a rapidly changing environment that is constantly meeting the physiological demands of the growing organism. During early postnatal development, the anterior pituitary is refining patterns of anterior hormone secretion in response to numerous genetic factors. Our lab previously developed a somatotrope leptin receptor (LEPR) deletion mouse model that had decreased lean body mass, disrupted metabolism, decreased GH stores and was GH deficient as an adult. To understand how deletion of LEPR in somatotropes altered GH, we turned our attention to postnatal development...
June 21, 2018: Journal of Endocrinology
Jingjing Du, Lei Zhang, QingBang Han
A novel included angle based weighting method is proposed for multi-linear model predictive control (MPC) of Hammerstein systems. It makes full use of the special structure of the Hammerstein models, and thus it is intuitive and simple. Moreover, there is only one tuning parameter and the weights can be calculated offline and stored in a look-up table. Therefore, online computational load is largely reduced. Most important of all, it schedules local controllers properly and effectively. A Lab-tank system which can be modeled into a Hammerstein model is investigated...
June 18, 2018: ISA Transactions
Somjot S Brar
No abstract text is available yet for this article.
June 26, 2018: Journal of the American College of Cardiology
Muhammad Arslan Kamal Hashmi, Beate I Escher, Martin Krauss, Ivana Teodorovic, Werner Brack
The release of a multitude of pollutants from untreated municipal wastewater (UMWW) to surface waters may have adverse effects on aquatic wildlife including endocrine disruption. For effect-directed analysis (EDA), a Danube river water sample downstream of emission of UMWW in Novi Sad, Serbia was extracted on-site and after processing in the lab was subjected to reporter gene assays which revealed pronounced estrogenic (ERα), androgenic (AR) and oxidative stress response (OSR). The sample was fractionated with reversed-phase high performance liquid chromatography (RP-HPLC) collecting thirty fractions at two-minute intervals...
May 15, 2018: Science of the Total Environment
Joseph R Iacona, Nicholas J Monteleone, Carol S Lutz
Arachidonic acid (AA) can be converted into prostaglandins (PGs) or leukotrienes (LTs) by the enzymatic actions of cyclooxygenases (COX-1 and COX-2) or 5-lipoxygenase (5-LO), respectively. PGs and LTs are lipid signaling molecules that have been implicated in various diseases, including multiple cancers. 5-LO and its activating protein (FLAP) work together in the first two conversion steps of LT production. Previous work has suggested a role for LTs in cancer development and progression. MicroRNAs (miRNAs) are small RNA molecules that negatively regulate gene expression post-transcriptionally, and have previously been shown to be involved in cancer...
June 1, 2018: Oncotarget
Bahaa Alshawaf, Hans-Peter Weber, Matthew Finkelman, Khaled El Rafie, Yukio Kudara, Panos Papaspyridakos
OBJECTIVES: The aim of this in vitro study was to compare the accuracy of printed implant casts from digital impressions with two intra-oral scanners (IOS) to stone casts from conventional impressions. The hypothesis was that printed casts would be more accurate than stone casts from conventional impressions. MATERIALS AND METHODS: A mandibular stone cast with Kennedy class II edentulism was fabricated using two internal connection tissue-level implants at 30 degrees to each other (Replace Select RP, Nobel Biocare) to serve as master...
June 21, 2018: Clinical Oral Implants Research
Carlos R Picanço, François Tonneau
Tracking eye movements is being increasingly recognized as a valuable source of information about stimulus control. So far, however, eye-tracking research has suffered from accessibility issues, with expensive hardware and closed-source software. In this article we review Pupil©, an eye-tracking platform developed by Pupil Labs and that combines open-source software with low-cost hardware components. We offer concrete recommendations about Pupil use in stimulus-control research and we show how the software can be extended to automatize the analysis of gaze data...
June 21, 2018: Journal of the Experimental Analysis of Behavior
Chuan Qin, Wen-Hao Zhang, De-Gang Yang, Ming-Liang Yang, Liang-Jie Du, Jian-Jun Li
Objective: To investigate the effects of myelotomy on locomotor recovery in rats subjected to spinal cord injury. Data Sources: Electronic databases including PubMed, Science Citation Index, Cochrane Library, China National Knowledge Infrastructure, Chinese Journals Full-text Database, China Biology Medicine disc, and Wanfang Database were searched to retrieve related studies published before September 2017. The MeSH terms (the Medical Subject Headings) such as "myelotomy", "spinal cord injuries", "rats", "randomized controlled trial" and all related entry terms were searched...
June 2018: Neural Regeneration Research
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