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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/29053610/lab-on-chip-surface-enhanced-raman-analysis-by-aerosol-jet-printing-and-roll-to-roll-hot-embossing
#2
Anne Habermehl, Noah Strobel, Ralph Eckstein, Nico Bolse, Adrian Mertens, Gerardo Hernandez-Sosa, Carsten Eschenbaum, Uli Lemmer
Surface-enhanced Raman spectroscopy (SERS) combines the high specificity of Raman scattering with high sensitivity due to an enhancement of the electromagnetic field by metallic nanostructures. However, the tyical fabrication methods of SERS substrates suffer from low throughput and therefore high costs. Furthermore, point-of-care applications require the investigation of liquid solutions and thus the integration of the SERS substrate in a microfluidic chip. We present a roll-to-roll fabrication approach for microfluidics with integrated, highly efficient, surface-enhanced Raman scattering structures...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053454/a-dataset-for-camera-independent-color-constancy
#3
Caglar Aytekin, Jarno Nikkanen, Moncef Gabbouj
In this paper, we provide a novel dataset designed for camera independent color constancy research. Camera independence corresponds to the robustness of an algorithm's performance when run on images of the same scene taken by different cameras. Accordingly, the images in our database correspond to several lab and field scenes each of which is captured by three different cameras with minimal registration errors. The lab scenes are also captured under five different illuminations. The spectral responses of cameras and the spectral power distributions of the lab light sources are also provided, as they may prove beneficial for training future algorithms to achieve color constancy...
October 17, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/29053450/two-dimensional-isoelectric-focusing-offgel-micro-fluidic-lab-on-chip-electrophoresis-and-ftir-for-assessment-of-long-term-stability-of-rhg-csf-formulation
#4
H Kraiem, F Zouari, R Ben Abderrazek, Y Manon, M El Ayeb, L Fillaudeau, J Bedoui, B Bouhaouala-Zahar
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) has been increasingly recognized from among one of the most abundant families of biosimilars. Upon long-term storage, rhG-CSF is subject to subtle chemical modifications that rapidly occur and, in particular, produce deaminated variants with divergent charge. Indeed, changes in charge from glutamine deamination may alter the way rhG-SCF will refold and the structure of resulting molecule. To assess this charge heterogeneity, 2D gel electrophoresis has limited application...
October 16, 2017: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/29053103/ultrasound-functional-imaging-in-an-i-ex-vivo-i-beating-porcine-heart-platform
#5
Niels J Petterson, Louis S Fixsen, Marcel C M Rutten, Nico H J Pijls, Frans N van de Vosse, Richard G P Lopata
In recent years, novel ultrasound functional imaging (UFI) techniques have been introduced to assess cardiac function by measuring, e.g., cardiac output (CO) and/or myocardial strain. Verification and reproducibility assessment in a realistic setting remain major issues. Simulations and phantoms are often unrealistic, whereas in vivo measurements often lack crucial hemodynamic parameters or ground truth data, or suffer from the large physiological and clinical variation between patients when attempting clinical validation...
October 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29053003/detoxification-of-cancerogenic-compounds-by-lactic-acid-bacteria-strains
#6
Zhao Lili, Wei Junyan, Zhao Hongfei, Zhu Baoqing, Zhang Bolin
Carcinogens in food are an important issue that threat people's health right now. Lactic acid bacteria (LAB) strains as well-known probiotics have shown numerous perspectives in being used as a good food additive to confront cancerogenic compounds in recent years. Some LAB strains can remove cancerogenic compounds from medium environment via direct physical binding and avoid re-pollution of poisonous secondary metabolites which are generated from degradation of cancerogenic compounds. This article presents a whole overview of the physical-binding of LAB strains to such common cancerogenic compounds existed in food and feed environments as mycotoxins, polycyclic aromatic hydrocarbons (PAHs), heterocyclic amines (HAs) and pthalic acid esters (PAEs)...
October 20, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29052740/short-term-effects-of-the-anti-sea-lice-therapeutant-emamectin-benzoate-on-clam-worms-nereis-virens
#7
G J McBriarty, K A Kidd, L E Burridge
The polychaete Nereis virens occurs commonly in marine sediments, is widely distributed, and is a popular bait species, as well as a potential replacement for wild-caught fish in commercial fish feed preparations. It is being considered as a potential co-extractive species for culture in integrated multi-trophic aquaculture operations. However, it is not known whether pesticides or drugs used to treat sea lice on farmed salmon, such as emamectin benzoate (EB), would adversely affect cultured or wild worms, because these compounds may persist in the environment...
October 20, 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29052459/paradoxical-thinking-as-a-conflict-resolution-intervention-comparison-to-alternative-interventions-and-examination-of-psychological-mechanisms
#8
Boaz Hameiri, Eden Nabet, Daniel Bar-Tal, Eran Halperin
Conflict-resolution interventions based on the paradoxical thinking principles, that is, expressing amplified, exaggerated, or even absurd ideas that are congruent with the held conflict-supporting societal beliefs, have been shown to be an effective avenue of intervention, especially among individuals who are adamant in their views. However, the question as to why these interventions have been effective has remained unanswered. In the present research, we have examined possible underlying psychological mechanisms, focusing on identity threat, surprise, and general disagreement...
October 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29052183/profiling-dna-methylation-using-bisulfite-sequencing-bs-seq
#9
Yun-Ru Chen, Sheng Yu, Silin Zhong
DNA cytosine methylation is one of the most abundant epigenetic marks found in the plant nuclear genome. Bisulfite sequencing (BS-Seq) is the method of choice for profiling DNA cytosine methylation genome-wide at a single nucleotide resolution. The basis of this technique is that the unmethylated cytosine can be deaminated to uracil by sodium bisulfite, while the methylated cytosine is resistant to the treatment. By deep sequencing of the bisulfite converted genomic DNA, the methylation level of each mappable cytosine position in the genome could be measured...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29051933/peptide-based-fibrin-targeting-probes-for-thrombus-imaging
#10
Bruno L Oliveira, Peter Caravan
The development of new methods to image the onset and progression of thrombosis is an unmet need. Non-invasive molecular imaging techniques targeting specific key structures involved in the formation of thrombosis have demonstrated the ability to detect thrombus in different disease state models and in patients. Due to its high concentration in the thrombus and its essential role in thrombus formation, the detection of fibrin is an attractive strategy for identification of thrombosis. Herein we provide an overview of recent and selected fibrin-targeted probes for molecular imaging of thrombosis by magnetic resonance imaging (MRI), positron emission tomography (PET), single photon emission computed tomography (SPECT), and optical techniques...
October 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29051929/fully-chip-embedded-automation-of-a-multi-step-lab-on-a-chip-process-using-a-modularized-timer-circuit
#11
Junsu Kang, Donghyeon Lee, Young Jin Heo, Wan Kyun Chung
For highly-integrated microfluidic systems, an actuation system is necessary to control the flow; however, the bulk of actuation devices including pumps or valves has impeded the broad application of integrated microfluidic systems. Here, we suggest a microfluidic process control method based on built-in microfluidic circuits. The circuit is composed of a fluidic timer circuit and a pneumatic logic circuit. The fluidic timer circuit is a serial connection of modularized timer units, which sequentially pass high pressure to the pneumatic logic circuit...
October 20, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/29051616/effects-of-inoculants-lactobacillus-brevis-and-lactobacillus-parafarraginis-on-the-fermentation-characteristics-and-microbial-communities-of-corn-stover-silage
#12
Zhenshang Xu, Huiying He, Susu Zhang, Jian Kong
To improve silage quality of crop forages, bacterial inoculants are often employed. In this study, Lactobacillus brevis SDMCC050297 and Lactobacillus parafarraginis SDMCC050300 were used as inoculants to corn stover in lab silos for ensiling. At the initial stage of ensiling, the pH value of the inoculated silages reduced more drastically, and the inoculated silages had higher lactic acid and acetic acid contents. After 20 days of ensiling, a reduction in lactic acid content coupled with an increase in acetic acid and 1,2-propanediol contents was observed in inoculated silages...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051378/quantum-control-of-molecular-collisions-at-1-kelvin
#13
William E Perreault, Nandini Mukherjee, Richard N Zare
Measurement of vector correlations in molecular scattering is an indispensable tool for mapping out interaction potentials. In a coexpanded supersonic beam, we have studied the rotationally inelastic process wherein deuterium hydride (HD) (v = 1, j = 2) collides with molecular deuterium (D2) to form HD (v = 1, j = 1), where v and j are the vibrational and rotational quantum numbers, respectively. HD (v = 1, j = 2) was prepared by Stark-induced adiabatic Raman passage, with its bond axis aligned preferentially parallel or perpendicular to the lab-fixed relative velocity...
October 20, 2017: Science
https://www.readbyqxmd.com/read/29051028/social-touch-interacts-with-infants-learning-of-auditory-patterns
#14
Casey Lew-Williams, Brock Ferguson, Rana Abu-Zhaya, Amanda Seidl
Infants' experiences are defined by the presence of concurrent streams of perceptual information in social environments. Touch from caregivers is an especially pervasive feature of early development. Using three lab experiments and a corpus of naturalistic caregiver-infant interactions, we examined the relevance of touch in supporting infants' learning of structure in an altogether different modality: audition. In each experiment, infants listened to sequences of sine-wave tones following the same abstract pattern (e...
September 29, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/29049565/a-low-cost-bioprosthetic-semilunar-valve-for-research-disease-modelling-and-surgical-training-applications
#15
Benoit Rosa, Zurab Machaidze, Borami Shin, Sunil Manjila, David W Brown, Christopher W Baird, John E Mayer, Pierre E Dupont
OBJECTIVES: This paper provides detailed instructions for constructing low-cost bioprosthetic semilunar valves for animal research and clinical training. This work fills an important gap between existing simulator training valves and clinical valves by providing fully functioning designs that can be employed in ex vivo and in vivo experiments and can also be modified to model valvular disease. METHODS: Valves are constructed in 4 steps consisting of creating a metal frame, covering it with fabric and attaching a suture ring and leaflets...
August 2, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29049280/ethoscopes-an-open-platform-for-high-throughput-ethomics
#16
Quentin Geissmann, Luis Garcia Rodriguez, Esteban J Beckwith, Alice S French, Arian R Jamasb, Giorgio F Gilestro
Here, we present the use of ethoscopes, which are machines for high-throughput analysis of behavior in Drosophila and other animals. Ethoscopes provide a software and hardware solution that is reproducible and easily scalable. They perform, in real-time, tracking and profiling of behavior by using a supervised machine learning algorithm, are able to deliver behaviorally triggered stimuli to flies in a feedback-loop mode, and are highly customizable and open source. Ethoscopes can be built easily by using 3D printing technology and rely on Raspberry Pi microcomputers and Arduino boards to provide affordable and flexible hardware...
October 2017: PLoS Biology
https://www.readbyqxmd.com/read/29048923/protocol-design-for-large-scale-cross-sectional-studies-of-surveillance-of-risk-factors-of-non-communicable-diseases-in-iran-steps-2016
#17
Shirin Djalalinia, Mitra Modirian, Ali Sheidaei, Moein Yoosefi, Hossein Zokaiee, Bahman Damirchilu, Zohreh Mahmoudi, Negar Mahmoudi, Mohammad Javad Hajipour, Niloofar Peykari, Nazila Rezaei, Rosa Haghshenas, Mohammad Hossein Mohammadi, Alireza Delavari, Mohammad Mehdi Gouya, Shohreh Naderimagham, Ahmad Kousha, Alireza Moghisi, Alireza Mahdavihezaveh, Kambiz Abachizadeh, Reza Majdzadeh, Ali Akbar Sayyari, Reza Malekzadeh, Bagher Larijani, Farshad Farzadfar
INTRODUCTION: The rise in non-communicable diseases (NCDs) has gained increasing attention. There is a great need for reliable data to address such problems. Here, we describe the development of a comprehensive set of executive and scientific protocols and instructions of STEPs 2016. METHODS/DESIGN: This is a large-scale cross-sectional study of Surveillance of Risk Factors of NCDs in Iran. Through systematic proportional to size cluster random sampling, 31,050 participants enrolled in three sequential processes, of completing questionnaires; physical measurements, and lab assessment...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29048855/-determination-of-strobilurin-fungicides-in-fruits-and-their-mass-fragmentation-routes-by-ultra-performance-liquid-chromatography-tandem-mass-spectrometry
#18
Yao Zhou, Huiqin Yang, Yiyin Shi, Jiaxian Chen, Jian Zhu, Xiaojun Deng, Dehua Guo
A method was developed for the simultaneous determination of six strobilurin fungicide (E-metominostrobin, azoxystrobin, kresoxim-methyl, picoxystrobin, pyraclostrobin and trifloxystrobin) residues in orange, banana, apple and pineapple samples by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). The fragmentation routes of all the compounds were explained by the aid of a fragment predicting software ACD Lab/MS Fragmenter. The samples were extracted by acetonitrile, then cleaned up by amino solid phase extraction cartridges (SupelClean LC-NH2)...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048533/parallel-sequencing-lives-or-what-makes-large-sequencing-projects-successful
#19
Javier Quilez, Enrique Vidal, François Le Dily, François Serra, Yasmina Cuartero, Ralph Stadhouders, Thomas Graf, Marc A Marti-Renom, Miguel Beato, Guillaume Filion
T47D_rep2 and b1913e6c1_51720e9cf were two Hi-C samples. They were born and processed at the same time, yet their fates were very different. The life of b1913e6c1_51720e9cf was simple and fruitful, while that of T47D_rep2 was full of accidents and sorrow. At the heart of these differences lies the fact that b1913e6c1_51720e9cf was born under a lab culture of Documentation, Automation, Traceability, Autonomy and compliance with the FAIR Principles. Their lives are a lesson for those who wish to embark on the journey of managing high throughput sequencing data...
October 18, 2017: GigaScience
https://www.readbyqxmd.com/read/29048467/identification-of-copy-number-variations-and-translocations-in-cancer-cells-from-hi-c-data
#20
Abhijit Chakraborty, Ferhat Ay
Motivation: Eukaryotic chromosomes adapt a complex and highly dynamic three-dimensional (3D) structure, which profoundly affects different cellular functions and outcomes including changes in epigenetic landscape and in gene expression. Making the scenario even more complex, cancer cells harbor chromosomal abnormalities (e.g., copy number variations (CNVs) and translocations) altering their genomes both at the sequence level and at the level of 3D organization. High-throughput chromosome conformation capture techniques (e...
October 18, 2017: Bioinformatics
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