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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/29222941/characterization-of-the-spoilage-potential-of-pure-and-mixed-cultures-of-bacterial-species-isolated-from-tropical-yellowfin-tuna-thunnus-albacares
#2
Adèle Silbande, Josiane Cornet, Mireille Cardinal, Frédérique Chevalier, Katia Rochefort, Juliette Smith-Ravin, Sandra Adenet, Françoise Leroi
AIM: The spoilage potential of 28 bacterial strains isolated from spoiled raw yellowfin tuna was evaluated. METHODS AND RESULTS: Bacterial species were inoculated in irradiated tuna matrix. Chemical changes, bacterial growth and sensory quality were monitored during aerobic storage at 8°C. Pseudomonas spp., Enterobacter spp. and Escherichia hermanii had no spoiling effect. Brochothrix thermosphacta and Carnobacterium divergens/maltaromaticum developed moderate unpleasant odors...
December 9, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29220998/characterization-and-control-of-a-multi-primary-led-light-lab
#3
Michael J Murdoch
A new light lab facility has been commissioned at Rochester Institute of Technology with the research goal of studying human visual adaptation under temporally dynamic lighting. The lab uses five-channel LED luminaires with 16 bits of addressable depth per channel, addressed via DMX. Based on spectral measurements, a very accurate multi-primary additive color model has been built that can be used to provide "colorimetric plus" multi-primary channel intensity solutions optimized for spectral accuracy, color fidelity, color gamut, or other attributes...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220991/assessing-uncertainties-in-scattering-correction-algorithms-for-reflective-tube-absorption-measurements-made-with-a-wet-labs-ac-9
#4
Nicole D Stockley, Rüdiger Röttgers, David McKee, Ina Lefering, James M Sullivan, Michael S Twardowski
In situ absorption measurements collected with a WET Labs ac-9 employing a reflective tube approach were scatter corrected using several possible methods and compared to reference measurements made by a PSICAM to assess performance. Overall, two correction methods performed best for the stations sampled: one using an empirical relationship between the ac-9 and PSICAM to derive the scattering error (ε) in the near-infrared (NIR), and one where ε was independently derived from concurrent measurements of the volume scattering function (VSF)...
November 27, 2017: Optics Express
https://www.readbyqxmd.com/read/29220087/dual-energy-based-metal-segmentation-for-metal-artifact-reduction-in-dental-computed-tomography
#5
Mohamed A A Hegazy, Mohamed Elsayed Eldib, Daniel Hernandez, Myung Hye Cho, Min Hyoung Cho, Soo Yeol Lee
PURPOSE: In a dental CT scan, the presence of dental fillings or dental implants generates severe metal artifacts that often compromise readability of the CT images. Many metal artifact reduction (MAR) techniques have been introduced, but dental CT scans still suffer from severe metal artifacts particularly when multiple dental fillings or implants exist around the region of interest. The high attenuation coefficient of teeth often causes erroneous metal segmentation, compromising the MAR performance...
December 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/29220011/the-labs-that-forge-distant-planets-here-on-earth
#6
Shannon Hall
No abstract text is available yet for this article.
December 7, 2017: Nature
https://www.readbyqxmd.com/read/29219971/a-celebration-of-spain-s-exemplary-lab-leaders
#7
Alison Abbott
No abstract text is available yet for this article.
December 7, 2017: Nature
https://www.readbyqxmd.com/read/29219761/the-fate-of-nitrite-and-nitrate-during-anaerobic-digestion
#8
K Ghyselbrecht, A Monballiu, M H Somers, I Sigurnjak, E Meers, L Appels, B Meesschaert
Anaerobic digestion is widely used to produce renewable energy. However, the main drawback is the limited conversion efficiency of organic matter. Applying an advanced oxidation process (AOP) as a digestate post-treatment is able to increase this conversion efficiency but will also lead to the oxidation of ammonium to nitrite or nitrate. In this lab scale study, the fate of the latter in the digester was investigated. Nitrite and nitrate were therefore added in concentrations that could arise from rate limiting ammonium concentrations (1...
December 8, 2017: Environmental Technology
https://www.readbyqxmd.com/read/29218886/clingen-cancer-somatic-working-group-standardizing-and-democratizing-access-to-cancer-molecular-diagnostic-data-to-drive-translational-research
#9
Subha Madhavan, Deborah Ritter, Christine Micheel, Shruti Rao, Angshumoy Roy, Dmitriy Sonkin, Matthew Mccoy, Malachi Griffith, Obi L Griffith, Peter Mcgarvey, Shashikant Kulkarni
A growing number of academic and community clinics are conducting genomic testing to inform treatment decisions for cancer patients (1). In the last 3-5 years, there has been a rapid increase in clinical use of next generation sequencing (NGS) based cancer molecular diagnostic (MolDx) testing (2). The increasing availability and decreasing cost of tumor genomic profiling means that physicians can now make treatment decisions armed with patient-specific genetic information. Accumulating research in the cancer biology field indicates that there is significant potential to improve cancer patient outcomes by effectively leveraging this rich source of genomic data in treatment planning (3)...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29218506/in-silico-discovery-of-novel-ligands-for-antimicrobial-lipopeptides-for-computer-aided-drug-design
#10
REVIEW
Satya Eswari Jujjavarapu, Swasti Dhagat
The increase in antibiotic-resistant strains of pathogens has created havoc worldwide. These antibiotic-resistant pathogens require potent drugs for their inhibition. Lipopeptides, which are produced as secondary metabolites by many microorganisms, have the ability to act as potent safe drugs. Lipopeptides are amphiphilic molecules containing a lipid chain bound to the peptide. They exhibit broad-spectrum activities against both bacteria and fungi. Other than their antimicrobial properties, they have displayed anti-cancer properties as well, but their mechanism of action is not understood...
December 7, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29217152/advanced-cardiopulmonary-resuscitation-cpr-in-the-catheterization-laboratory-consensus-document-of-the-working-groups-of-1-cardiopulmonary-resuscitation-acute-cardiac-care-and-2-hemodynamic-and-interventional-cardiology-hellenic-cardiological-society
#11
George Latsios, George Mpompotis, Kostas Tsioufis, Kostas Toutouzas, Emmanouil Skalidis, Andreas Synetos, Dimosthenis Avramidis, Dimitris Tousoulis
The incidence of Cardiac (Cardio-Pulmonary) Arrest (CA) in the Catheterization Laboratory is not common. However, not only does it happen occasionally but its frequency tends to increase due to the increase in the overall number and complexity of interventions performed by interventional cardiologists. Therefore, certified knowledge and application of the ALS (Advanced Life Support) protocols by trained Catheterization Laboratory staff is imperative in many countries, by local Hospital standards and also by Law...
December 4, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29216185/a-cyber-linked-undergraduate-research-experience-in-computational-biomolecular-structure-prediction-and-design
#12
Rebecca F Alford, Andrew Leaver-Fay, Lynda Gonzales, Erin L Dolan, Jeffrey J Gray
Computational biology is an interdisciplinary field, and many computational biology research projects involve distributed teams of scientists. To accomplish their work, these teams must overcome both disciplinary and geographic barriers. Introducing new training paradigms is one way to facilitate research progress in computational biology. Here, we describe a new undergraduate program in biomolecular structure prediction and design in which students conduct research at labs located at geographically-distributed institutions while remaining connected through an online community...
December 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29216150/two-dimensional-microbend-sensor-based-on-long-period-fiber-gratings-in-an-isosceles-triangle-arrangement-three-core-fiber
#13
Song Wang, Weigang Zhang, Lei Chen, Yanxin Zhang, Pengcheng Geng, Yunshan Zhang, Tieyi Yan, Lin Yu, Wei Hu, Yanping Li
To realize the 2D microbend sensor, we design and fabricate two non-orthogonal long-period fiber gratings (LPFGs) in an isosceles triangle arrangement three-core optical fiber which is made in our lab, making an isosceles triangle arrangement three-core optical fiber. To mark two directions without crosstalk, we write two different periods of LPFG in each of the two external cores and the central core, which induces a strong asymmetric refractive index arrangement in the fiber cross section. Theoretical analysis and experimental results verify that the resonant wavelength originates from the tunneling between the LP01 core mode in the center core and the external core...
December 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/29215768/from-a-metastable-layer-to-a-stable-ring-a-kinetic-study-for-transformation-reactions-of-li2mo3teo12-to-polyoxometalates
#14
Seung-Jin Oh, Seong-Ji Lim, Tae-Soo You, Kang Min Ok
A metastable tellurite, Li2Mo3TeO12, revealing a corrugated layered structure in an extremely strained coordination environment was hydrothermally synthesized in high yield. Li2Mo3TeO12 undergoes Li+-exchange-driven facile structural transformation reactions to polyoxometalates. The kinetic data for the transformation reactions at various conditions were successfully obtained by simple lab-source powder X-ray diffraction. The investigation suggests that the solid-state transformation reactions may occur through the substitution, decomposition, recombination, and precipitation steps in order...
December 7, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29215764/an-evaluation-of-the-challenges-to-developing-tumour-brca1-and-brca2-testing-methodologies-for-clinical-practice
#15
Gillian Ellison, Miika Ahdesmäki, Sally Luke, Paul M Waring, Andrew Wallace, Ronnie Wright, Benno Röthlisberger, Katja Ludin, Sabine Merkelbach-Bruse, Carina Heydt, Marjolijn J L Ligtenberg, Arjen R Mensenkamp, David Gonzalez Castro, Thomas Jones, Ana Vivancos, Olga Kondrashova, Patrick Pauwels, Christine Weyn, Eric Hahnen, Jan Hauke, Richie Soong, Zhongwu Lai, Brian Dougherty, T Hedley Carr, Justin Johnson, John Mills, J Carl Barrett
Ovarian cancer patients with germline or somatic pathogenic variants benefit from treatment with PARP inhibitors. Tumour BRCA1/2 testing is more challenging than germline testing as the majority of samples are formalin fixed paraffin embedded (FFPE), the tumour genome is complex and the allelic fraction of somatic variants can be low. We collaborated with 10 laboratories testing BRCA1/2 in tumours to compare different approaches to identify clinically important variants within FFPE tumour DNA samples. This was not a proficiency study but an inter-laboratory comparison to identify common issues...
December 7, 2017: Human Mutation
https://www.readbyqxmd.com/read/29215547/hypnosis-as-an-effective-and-inexpensive-option-to-control-pain-in-transcatheter-ablation-of-cardiac-arrhythmias
#16
Umberto Barbero, Federico Ferraris, Milena Muro, Carlo Budano, Matteo Anselmino, Fiorenzo Gaita
: Supportive care for pain relief and back discomfort during electrophysiology interventions is usually needed in the electrophysiology lab, especially in long-lasting procedures like atrial fibrillation ablation. Although this is usually achieved with conventional pharmacologic anesthesia, hypnosis has recently aroused interest as a reliable tool to complement and possibly enhance conscious sedation. We collected five case of percutaneous arrhythmia ablation in which, after informed consent, hypnosis was performed by nurse anesthetists in the cath lab...
January 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29215284/molecular-scale-description-of-span80-desorption-from-a-squalane-water-interface
#17
Liang Tan, Lawrence R Pratt, Mangesh I Chaudhari
Extensive all-atom molecular dynamics calculations on the water-squalane interface for nine different loadings with sorbitan monooleate (SPAN80), at T=300K, are analyzed for the surface tension equation of state, desorption free energy profiles as they depend on loading, and to evaluate escape times for adsorbed SPAN80 into the bulk phases. These results suggest that loading only weakly affects accommodation of a SPAN80 molecule by this squalane-water interface. Specifically, the surface tension equation of state is simple through the range of high tension to high loading studied, and the desorption free energy profiles are weakly dependent on loading here...
December 7, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29215197/enrichment-of-gamma-aminobutyric-acid-in-bean-sprouts-exploring-biosynthesis-of-plant-metabolite-using-common-household-reagents
#18
Theerasak Rojanarata, Samarwadee Plianwong, Praneet Opanasopit, Tanasait Ngawhirunpat
The enrichment of plant foods with gamma-aminobutyric acid (GABA) is currently an interesting issue in the field of nutraceuticals and can be used as an experiment for upper-division undergraduate students. Here, an interdisciplinary hands-on experiment to produce GABA-enriched mung bean sprouts using common household reagents is described. Based on the GABA biosynthesis pathways, two key factors, being the availability of l-glutamic acid and the acidification of the germination environment, were chosen for the study of the effects on the enhancement of GABA levels...
December 7, 2017: Biochemistry and Molecular Biology Education
https://www.readbyqxmd.com/read/29214545/daily-activity-patterns-and-thermal-tolerance-of-three-sympatric-dung-beetle-species-scarabaeidae-scarabaeinae-eucraniini-from-the-monte-desert-argentina
#19
V C Giménez Gómez, S B Lomáscolo, G A Zurita, F Ocampo
Tolerance to extreme temperatures, thermal limits, and the mechanisms of thermoregulation are related to internal functions of insects and partly define their ecological niche. We study the association between daily activity of dung beetles from the Monte Desert in Argentina and their tolerance to high temperatures. Results indicate that for all three sympatric species studied, Eucranium belenae Ocampo, Anomiopsoides cavifrons (Burmeister), and Anomiopsoides fedemariai Ocampo, daily activity is associated to ground temperature...
December 6, 2017: Neotropical Entomology
https://www.readbyqxmd.com/read/29214425/can-smartphones-be-used-to-bring-computer-based-tasks-from-the-lab-to-the-field-a-mobile-experience-sampling-method-study-about-the-pace-of-life
#20
Stefan Stieger, David Lewetz, Ulf-Dietrich Reips
Researchers are increasingly using smartphones to collect scientific data. To date, most smartphone studies have collected questionnaire data or data from the built-in sensors. So far, few studies have analyzed whether smartphones can also be used to conduct computer-based tasks (CBTs). Using a mobile experience-sampling method study and a computer-based tapping task as examples (N = 246; twice a day for three weeks, 6,000+ measurements), we analyzed how well smartphones can be used to conduct a CBT. We assessed methodological aspects such as potential technologically induced problems, dropout, task noncompliance, and the accuracy of millisecond measurements...
December 6, 2017: Behavior Research Methods
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