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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/28227960/automated-volumetry-for-unilateral-hippocampal-sclerosis-detection-in-patients-with-temporal-lobe-epilepsy
#2
Cristina Martins, Nadia Moreira da Silva, Guilherme Silva, Verena E Rozanski, Joao Paulo Silva Cunha, Cristina Martins, Nadia Moreira da Silva, Guilherme Silva, Verena E Rozanski, Joao Paulo Silva Cunha, Joao Paulo Silva Cunha, Guilherme Silva, Verena E Rozanski, Nadia Moreira da Silva, Cristina Martins
Hippocampal sclerosis (HS) is the most common cause of temporal lobe epilepsy (TLE) and can be identified in magnetic resonance imaging as hippocampal atrophy and subsequent volume loss. Detecting this kind of abnormalities through simple radiological assessment could be difficult, even for experienced radiologists. For that reason, hippocampal volumetry is generally used to support this kind of diagnosis. Manual volumetry is the traditional approach but it is time consuming and requires the physician to be familiar with neuroimaging software tools...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227950/designing-and-testing-a-wearable-wireless-fnirs-patch
#3
Mohammadreza Abtahi, Gozde Cay, Manob Jyoti Saikia, Kunal Mankodiya, Mohammadreza Abtahi, Gozde Cay, Manob Jyoti Saikia, Kunal Mankodiya, Manob Jyoti Saikia, Kunal Mankodiya, Gozde Cay, Mohammadreza Abtahi
Optical brain monitoring using near infrared (NIR) light has got a lot of attention in order to study the complexity of the brain due to several advantages as oppose to other methods such as EEG, fMRI and PET. There are a few commercially available functional NIR spectroscopy (fNIRS) brain monitoring systems, but they are still non-wearable and pose difficulties in scanning the brain while the participants are in motion. In this work, we present our endeavors to design and test a low-cost, wireless fNIRS patch using NIR light sources at wavelengths of 770 and 830nm, photodetectors and a microcontroller to trigger the light sources, read photodetector's output and transfer data wirelessly (via Bluetooth) to a smart-phone...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227877/a-wearable-computing-platform-for-developing-cloud-based-machine-learning-models-for-health-monitoring-applications
#4
Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari, Shyamal Patel, Ryan S McGinnis, Ikaro Silva, Steve DiCristofaro, Nikhil Mahadevan, Elise Jortberg, Jaime Franco, Albert Martin, Joseph Lust, Milan Raj, Bryan McGrane, Paolo DePetrillo, A J Aranyosi, Melissa Ceruolo, Jesus Pindado, Roozbeh Ghaffari
Wearable sensors have the potential to enable clinical-grade ambulatory health monitoring outside the clinic. Technological advances have enabled development of devices that can measure vital signs with great precision and significant progress has been made towards extracting clinically meaningful information from these devices in research studies. However, translating measurement accuracies achieved in the controlled settings such as the lab and clinic to unconstrained environments such as the home remains a challenge...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227820/evaluating-respiratory-muscle-activity-using-a-wireless-sensor-platform
#5
Luis Estrada, Abel Torres, Leonardo Sarlabous, Raimon Jane, Luis Estrada, Abel Torres, Leonardo Sarlabous, Raimon Jane, Raimon Jane, Luis Estrada, Leonardo Sarlabous, Abel Torres
Wireless sensors are an emerging technology that allows to assist physicians in the monitoring of patients health status. This approach can be used for the non-invasive recording of the electrical respiratory muscle activity of the diaphragm (EMGdi). In this work, we acquired the EMGdi signal of a healthy subject performing an inspiratory load test. To this end, the EMGdi activity was captured from a single channel of electromyography using a wireless platform which was compared with the EMGdi and the inspiratory mouth pressure (Pmouth) recorded with a conventional lab equipment...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227815/lab-on-chips-for-manipulation-of-small-scale-organisms-to-facilitate-imaging-of-neurons-and-organs
#6
Ramtin Ardeshiri, Pouya Rezai, Ramtin Ardeshiri, Pouya Rezai, Ramtin Ardeshiri, Pouya Rezai
Caenorhabditis elegans (C. elegans) and Drosophila melanogaster (D. melanogaster) are widely-used model organisms for neurological and cardiac studies due to their simple neuronal (302 neurons in C. elegans) and cardiac (simple tubular organ in D. melanogaster) systems. However, their small sizes and continuous mobility impede their precise and timely manipulation, hence, limiting the assays that can be done using conventional manual methods. This has resulted in a need for technologies that allow multidirectional manipulation of model organisms to enable studies on target neurons and organs throughout the body...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227805/modular-multipin-electrodes-for-comfortable-dry-eeg
#7
P Fiedler, D Strohmeier, A Hunold, S Griebel, R Muhle, M Schreiber, P Pedrosa, B Vasconcelos, C Fonseca, F Vaz, J Haueisen, P Fiedler, D Strohmeier, A Hunold, S Griebel, R Muhle, M Schreiber, P Pedrosa, B Vasconcelos, C Fonseca, F Vaz, J Haueisen, P Pedrosa, F Vaz, P Fiedler, B Vasconcelos, J Haueisen, M Schreiber, R Muhle, C Fonseca, S Griebel, D Strohmeier, A Hunold
Electrode and cap concepts for continuous and ubiquitous monitoring of brain activity will open up new fields of application and contribute to increased use of electroencephalography (EEG) in clinical routine, neurosciences, brain-computer-interfacing and out-of-the-lab monitoring. However, mobile and unobtrusive applications are currently hindered by the lack of applicable convenient and reliable electrode and cap systems. We propose a novel modular electrode concept based on a flexible polymer substrate, coated with electrically conductive metallic films...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227794/a-numerical-and-experimental-study-of-acoustic-micromixing-in-3d-microchannels-for-lab-on-a-chip-devices
#8
Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Susana O Catarino, Vania C Pinto, Paulo J Sousa, Rui Lima, Joao M Miranda, Graca Minas, Joao M Miranda, Paulo J Sousa, Susana O Catarino, Rui Lima, Vania C Pinto, Graca Minas
This paper reports a numerical and experimental study of acoustic streaming and micromixing in polydimethylsiloxane microchannels. The mixing between two fluids flowing in microchannels was evaluated through the following conditions: (1) using a 28 μm thick β-poly(vinylidene fluoride) (β-PVDF) as a piezoelectric transducer actuated with a 24 Vpp and 40 MHz sinusoidal voltage; (2) using different flow rates. The results suggest that the mixing length increases as the flow rate increases and that the acoustic streaming phenomenon leads to a reduction on the mixing length...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227244/towards-development-of-a-mobile-rf-doppler-sensor-for-continuous-heart-rate-variability-and-blood-pressure-monitoring
#9
Insoo Kim, Yusuf A Bhagat, Insoo Kim, Yusuf A Bhagat, Insoo Kim, Yusuf A Bhagat
The standard in noninvasive blood pressure (BP) measurement is an inflatable cuff device based on the oscillometric method, which poses several practical challenges for continuous BP monitoring. Here, we present a novel ultra-wide band RF Doppler radar sensor for next-generation mobile interface for the purpose of characterizing fluid flow speeds, and for ultimately measuring cuffless blood flow in the human wrist. The system takes advantage of the 7.1~10.5 GHz ultra-wide band signals which can reduce transceiver complexity and power consumption overhead...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227146/power-management-design-for-lab-on-chip-biosensors
#10
Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Xiaojian Yu, Kambiz Moez, I-Chyn Wey, Jie Chen, Kambiz Moez, Xiaojian Yu, I-Chyn Wey, Jie Chen
Over the past decades, we have witnessed the growth demands of portable lab-on-chip biosensors. These lab-on-chip devices are mostly powered by battery, and intelligent power management systems are required to provide supply voltage for different functional units on biosensors (e.g. a microfluidic control system might require higher voltage than the rest working units of biosensors). In this paper, a fully integrated multiple-stage voltage multiplier is proposed to provide high-voltage power needs. The proposed design was implemented with the IBM's 0...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227109/probabilistic-characterization-of-sleep-architecture-home-based-study-on-healthy-volunteers
#11
Gary Garcia-Molina, Sreeram Vissapragada, Anandi Mahadevan, Robert Goodpaster, Brady Riedner, Michele Bellesi, Giulio Tononi, Gary Garcia-Molina, Sreeram Vissapragada, Anandi Mahadevan, Robert Goodpaster, Brady Riedner, Michele Bellesi, Giulio Tononi, Robert Goodpaster, Brady Riedner, Michele Bellesi, Giulio Tononi, Gary Garcia-Molina, Sreeram Vissapragada, Anandi Mahadevan
The quantification of sleep architecture has high clinical value for diagnostic purposes. While the clinical standard to assess sleep architecture is in-lab based polysomnography, higher ecological validity can be obtained with multiple sleep recordings at home. In this paper, we use a dataset composed of fifty sleep EEG recordings at home (10 per study participant for five participants) to analyze the sleep stage transition dynamics using Markov chain based modeling. The statistical analysis of the duration of continuous sleep stage bouts is also analyzed to identify the speed of transition between sleep stages...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227009/a-machine-learning-framework-for-auto-classification-of-imaging-system-exams-in-hospital-setting-for-utilization-optimization
#12
Meru A Patil, Ravindra B Patil, P Krishnamoorthy, Jacob John, Meru A Patil, Ravindra B Patil, P Krishnamoorthy, Jacob John, Meru A Patil, Jacob John, Ravindra B Patil, P Krishnamoorthy
In clinical environment, Interventional X-Ray (IXR) system is used on various anatomies and for various types of the procedures. It is important to classify correctly each exam of IXR system into respective procedures and/or assign to correct anatomy. This classification enhances productivity of the system in terms of better scheduling of the Cath lab, also provides means to perform device usage/revenue forecast of the system by hospital management and focus on targeted treatment planning for a disease/anatomy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226890/stability-of-the-microdroplets-for-portable-biosensor
#13
Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Koki Kamiya, Satoshi Fujii, Norihisa Miki, Shoji Takeuchi, Yusuke Izawa, Toshihisa Osaki
This paper highlights the behavior of microdroplets used for portable biosensors. Microdroplets have been applied for various Lab-on-a-chip applications, in which portability/wearable is becoming a trend word. However, the resonance (sloshing phenomena) of the microdroplets could be an issue. For example, bilayer lipid membrane, fragile characteristics due to its thickness of 5 nm, easily ruptures by jiggling. We therefore prepared various dimensions of droplets by changing the well shape, and examined the resulting waves depending on the vibration frequency between 20 and 100 Hz, including daily life frequencies...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226746/artery-vein-classification-of-retinal-blood-vessels-using-feature-selection
#14
Vishal Vijayakumar, Dara D Koozekanani, Robert White, James Kohler, Sohini Roychowdhury, Keshab K Parhi, Vishal Vijayakumar, Dara D Koozekanani, Robert White, James Kohler, Sohini Roychowdhury, Keshab K Parhi, James Kohler, Keshab K Parhi, Vishal Vijayakumar, Sohini Roychowdhury, Robert White, Dara D Koozekanani
Automated classification of retinal vessels in fundus images is the first step towards measurement of retinal characteristics that can be used to screen and diagnose vessel abnormalities for cardiovascular and retinal disorders. This paper presents a novel approach to vessel classification to compute the artery/vein ratio (AVR) for all blood vessel segments in the fundus image. The features extracted are then subjected to a selection procedure using Random Forests (RF) where the features that contribute most to classification accuracy are chosen as input to a polynomial kernel Support Vector Machine (SVM) classifier...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226537/automated-transepithelial-electrical-resistance-measurements-of-the-epiderm-reconstructed-human-epidermis-model
#15
Frank A Alexander, Joachim Wiest, Frank A Alexander, Joachim Wiest, Joachim Wiest, Frank A Alexander
Understanding the effect of exogenous substances on human skin is critical for toxicology assessment. To address this, numerous artificial models of the topmost layer of human skin, so-called reconstructed human epidermis (RhE), have been created in an attempt to produce a clear analogue for testing. Unfortunately, current testing modalities still rely on endpoint assays and are not capable of monitoring time-resolved changes in barrier function without using numerous redundant samples. In this work, a novel, time-resolved approach is realized by monitoring the transepithelial electrical resistance (TEER) of MatTek EpiDerm® reconstructed human epidermis model, utilizing an automated protocol with the Intelligent Mobile Lab for in vitro diagnostics (IMOLA-IVD)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226426/physiological-mechanisms-for-stabilizing-the-limb-when-acting-against-physical-constraints
#16
P Senot, L Damm, M Tagliabue, J McIntyre, P Senot, L Damm, M Tagliabue, J McIntyre, P Senot, L Damm, M Tagliabue, J McIntyre
Smooth physical interaction with our environment, such as when working with tools, requires adaptability to unpredictable perturbations that can be achieved through impedance control of multi-joint limbs. Modulation of arm stiffness can be achieved either increasing co-contraction of antagonistic muscles or by increasing the gain of spinal reflex loops. According to the "automatic gain scaling" principle, the spinal reflex gain, as measured via the H-reflex, scales with muscle activation. A previous experiment from our labs suggested, however, that reflex gains might instead be scaled to the force exerted by the limb, perhaps as a means to counteract destabilizing external forces...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226250/improved-performance-of-gravity-driven-membrane-filtration-for-seawater-pretreatment-implications-of-membrane-module-configuration
#17
Bing Wu, Tino Christen, Hwee Sin Tan, Florian Hochstrasser, Stanislaus Raditya Suwarno, Xin Liu, Tzyy Haur Chong, Michael Burkhardt, Wouter Pronk, Anthony G Fane
As a low energy and chemical free process, gravity-driven membrane (GDM) filtration has shown a potential for seawater pretreatment in our previous studies. In this study, a pilot submerged GDM reactor (effective volume of 720 L) was operated over 250 days and the permeate flux stabilized at 18.6 ± 1.4 L/m(2)h at a hydrostatic pressure of 40 mbar. This flux was higher than those in the lab-scale GDM reactor (16.3 ± 0.2 L/m(2)h; effective volume of 8.4 L) and in the filtration cell system (2.7 ± 0...
February 16, 2017: Water Research
https://www.readbyqxmd.com/read/28225823/a-novel-approach-to-eliminate-detection-of-contaminating-staphylococcal-species-introduced-during-clinical-testing
#18
Wanyuan Ao, Adrianne Clifford, Maylene Corpuz, Robert Jenison
We describe here a strategy that can distinguish between Staphylococcus species truly present in a clinical sample from contaminating Staphylococcus species introduced during the testing process. Contaminating Staphylococcus species are present at low levels in PCR reagents and colonize lab personnel. To eliminate detection of contaminants, we describe an approach that utilizes addition of sufficient quantities of either non-target Staphylococcal cells (Staphylococcus succinus or Staphylococcus muscae) or synthetic oligonucleotide templates to helicase dependent isothermal amplification reactions to consume Staphylococcus-specific tuf and mecA gene primers such that contaminating Staphylococcus amplification is suppressed to below assay limits of detection...
2017: PloS One
https://www.readbyqxmd.com/read/28225124/electrowetting-without-external-voltage-using-paint-on-electrodes
#19
Collin B Eaker, Ishan D Joshipura, Logan R Maxwell, Jason Heikenfeld, Michael D Dickey
Electrowetting uses voltage to manipulate small volumes of fluid for applications including lab-on-a-chip and optical devices. To avoid electrochemical reactions, a dielectric often separates the fluid from the electrode, which has the undesired effect of adding processing steps while increasing the voltage necessary for electrowetting. We present a new method to dramatically reduce the complexity of electrode and dielectric fabrication while enabling multiple performance advances. This method relies on a self-oxidizing paint-on liquid-metal electrode that can be fabricated in minutes on rigid, rough, or even elastic substrates, enabling low operation voltages (<1 V), and self-healing upon dielectric breakdown...
February 22, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28224905/emerging-trends-in-biosensing-using-stripping-voltammetric-detection-of-metal-containing-nanolabels-a-review
#20
REVIEW
Christos Kokkinos, Anastasios Economou
Over the last years, nanomaterials have found many applications in the development of electrochemical biosensors. Among other functions, metal nanoparticles (NPs) and quantum dots (QDs) (semiconducting nanocrystals composed of metal salts) are increasingly being used as voltammetric labels in affinity biosensing. Labeling is based on the attachment of the label(s) on the target biomolecules or on a biorecognition reporting probe. After an appropriate specific affinity interaction between the target and the reporting probe, the metallic nanolabels are converted to the respective cations which are quantified by a voltammetric technique...
April 8, 2017: Analytica Chimica Acta
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