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https://www.readbyqxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet, Julian Marsden, Kendall Ho, Christina Krause, James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: BC medical journal: BCMJ
https://www.readbyqxmd.com/read/28822244/new-insights-into-the-enhanced-performance-of-high-solid-anaerobic-digestion-with-dewatered-sludge-by-thermal-hydrolysis-organic-matter-degradation-and-methanogenic-pathways
#2
Sisi Chen, Ning Li, Bin Dong, Wentao Zhao, Lingling Dai, Xiaohu Dai
Two lab-scale high solid anaerobic digesters fed with untreated sludge (R1) and thermally hydrolyzed sludge (R2) were operated to investigate the influence of thermal hydrolysis pretreatment (THP) on the degradation of individual macromolecular organic components (MOCs), as well as the functional and metabolic responses of microbes during anaerobic digestion (AD). The degradation of MOCs was improved by THP at different rates, in which improved degradation of proteins (by 49.0%) and hemicelluloses (by 25.0%) were the main factors contributing to the increase in volatile solids (VS) reduction...
August 8, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28821648/bilingual-language-switching-in-the-lab-vs-in-the-wild-the-spatio-temporal-dynamics-of-adaptive-language-control
#3
Esti Blanco-Elorrieta, Liina Pylkkänen
For a bilingual human, every utterance requires a choice about which language to use. This choice is commonly regarded as part of general executive control, engaging prefrontal and anterior cingulate cortices similarly to many types of effortful task-switching. However, while language control within artificial switching paradigms has been heavily studied, the neurobiology of natural switching within socially cued situations has not been characterized. Additionally, although theoretical models address how language control mechanisms adapt to the distinct demands of different interactional contexts, these predictions have not been empirically tested...
August 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28821570/juvenile-hormone-but-not-nutrition-or-social-cues-affects-reproductive-maturation-in-solitary-alkali-bees-nomia-melanderi
#4
Karen M Kapheim, Makenna M Johnson
Eusocial insect colonies are defined by extreme variation in reproductive activity among castes, but the ancestral conditions from which this variation arose are unknown. Investigating the factors that contribute to variation in reproductive physiology among solitary insects that are closely related to social species can help to fill this gap. We experimentally tested the role of nutrition, juvenile hormone, and social cues on reproductive maturation in solitary alkali bees (Halictidae: Nomia melanderi). We find that alkali bee females emerge from overwintering with small Dufour's glands and small ovaries, containing oocytes in the early stages of development...
August 18, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28820998/photosynthesis-of-alfalfa-medicago-sativa-in-response-to-landfill-leachate-contamination
#5
Lie Yang, Tiantian Sun, Yanli Liu, Houqing Guo, Lixin Lv, Jie Zhang, Chang Liu
Thousands of unlined landfills and open dumpsites have put great threat on the security of soil and ground water due to leachate leakage. Alfalfa is believed potential as a phytoremediation plant for leachate contamination based on strong root system and the excellent capacity of removing various kinds of pollutants. A lab-scale investigation was conducted to figure out the sensitiveness of alfalfa photosynthesis in response to leachate contamination. The results demonstrated that both of the maximum photosynthetic efficiency (Fv/Fm) and net photosynthetic rate (Pn) were slightly inhibited in the high-dosage group...
August 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28820754/sleep-apps-what-role-do-they-play-in-clinical-medicine
#6
Christopher P Lorenz, Adrian J Williams
PURPOSE OF REVIEW: Today's smartphones boast more computing power than the Apollo Guidance Computer. Given the ubiquity and popularity of smartphones, are we already carrying around miniaturized sleep labs in our pockets? RECENT FINDINGS: There is still a lack of validation studies for consumer sleep technologies in general and apps for monitoring sleep in particular. To overcome this gap, multidisciplinary teams are needed that focus on feasibility work at the intersection of software engineering, data science and clinical sleep medicine...
August 17, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28820751/importance-of-pcr-based-tumor-testing-in-the-evaluation-of-lynch-syndrome-associated-endometrial-cancer
#7
Amanda S Bruegl, Annessa Kernberg, Russell R Broaddus
Lynch syndrome (LS) is a hereditary cancer syndrome caused by a germline mutation in a DNA mismatch repair gene, usually MLH1, MSH2, MSH6, or PMS2. The most common cancers associated with LS are colorectal adenocarcinoma and endometrial carcinoma. Identification of women with LS-associated endometrial cancer is important, as these women and their affected siblings and children are at-risk of developing these same cancers. Germline testing of all endometrial cancer patients is not cost effective, and screening using young age of cancer diagnosis and/or presence of family history of syndrome-associated is underutilized and ineffective...
August 17, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28820423/-risk-factors-and-special-aspects-forgenital-tuberculosis-diagnostics
#8
G Lortkipanidze, N Kintraia, K Vacharadze, F Tsaava
Was examined 453 women, who applied to National Center for Tuberculosis and Lung Diseases for genital tuberculosis diagnostics. GTB was detected in 289 cases, in 164 cases GTB results was negative (control group). In 10 cases GTB was combined with pulmonary tuberculosis (OR-1,13). Risk factors are previous diseases of female reproductive organs- intracellular infection (OR-1,08), sexually transmitted diseases (OR-1,25), nonspecific inflammatory diseases (OR-1,009), interruption of pregnancy (OR-1,26), artificial abortions (OR-1,11), the most specific signs of Genital Tuberculosis is a pain in the stomach area (P-0,023), dysmenorrhoea (P-0,00001), intestinal obstruction (P-0,0006), heat (P-0,00001), liquid presence in posterior vault (P-0,007), hydrosalpinx (P-0,00001), Fallopian tubes deformation (P-0,000003), oophoritic cyst (P-0,067), adhesive process in small pelvis (P-0,0006)...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28818795/mitigating-inhibition-of-undissociated-volatile-fatty-acids-vfas-for-enhanced-sludge-rice-bran-composting-with-ferric-nitrate-amendment
#9
Zongqi Shou, Haiping Yuan, Yanwen Shen, Jiayun Liang, Nanwen Zhu, Lin Gu
This study investigated the effect of ferric nitrate on mitigating the inhibition of volatile fatty acids (VFAs) during the initial phase of sewage sludge composting amended with rice bran. During the 34-day lab-scale composting, the supplementation of ferric nitrate enhanced the degradation of VFAs by up to 3 times as compared to the control. The organic matters loss (OML) rate in the treatment reactor was almost doubled with supplementation of ferric nitrate as compared to the control reactor during the initial phase...
August 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28818774/a-quantum-dot-based-fluoroassay-for-detection-of-food-borne-pathogens
#10
Elaheh Mohamadi, Mohammadali Moghaddasi, Afshin Farahbakhsh, Abbass Kazemi
Evaluation of the distribution capability of food-borne pathogens existing in food products by taking the advantage of quantum dots (QDs) for their photoluminescence properties was carried out. Bacteria namely Escherichia coli (E. coli) labelled with CdSe-QDs were examined both on an Agar nutrient and ground fish substrates in order to observe their growth rate in different environments in the Lab. A sample with an appropriate concentration ratio 10(7)CFU/mL of bacteria/CdSe-QDs was empirically selected from the samples which were grown on the Agar containing plates...
August 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28818653/robust-and-thermal-healing-superhydrophobic-surfaces-by-spin-coating-of-polydimethylsiloxane
#11
Mengying Long, Shan Peng, Wanshun Deng, Xiaojun Yang, Kai Miao, Ni Wen, Xinrui Miao, Wenli Deng
HYPOTHESIS: Superhydrophobic surfaces easily lose their excellent water-repellency after damages, which limit their broad applications in practice. Thus, the fabrication of superhydrophobic surfaces with excellent durability and thermal healing should be taken into consideration. EXPERIMENTS: In this work, robust superhydrophobic surfaces with thermal healing were successfully fabricated by spin-coating method. To achieve superhydrophobicity, cost-less and fluoride-free polydimethylsiloxane (PDMS) was spin-coated on rough aluminum substrates...
August 10, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28818590/emerging-and-legacy-flame-retardants-in-indoor-dust-from-east-china
#12
Changfeng Peng, Hongli Tan, Ying Guo, Yan Wu, Da Chen
To understand human exposure to dust-associated flame retardants in the biggest metropolitan area (city of Shanghai) of East China, our study determined a suite of legacy and emerging flame retardants in dust from dwellings, cars, and university computer labs. The results exhibited a consistent dominance of organophosphate flame retardants (OPFRs) over polybrominated diphenyl ethers (PBDEs) and other alternative flame retardants (AFRs) regardless of microenvironments. In addition to OPFRs, some alternative flame retardants, such as decabromodiphenyl ethane (DBDPE), 2-ethylhexyltetrabromobenzoate (EH-TBB), bis(2-ethylhexyl)-3,4,5,6-tetrabromobenzoate (BEH-TEBP), and 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), were also frequently detected...
August 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28818539/playing-a-rigged-game-inequality-s-effect-on-physiological-stress-responses
#13
Martin S Shapiro, Rhanda Rylant, Amanda de Lima, Andrea Vidaurri, Herman van de Werfhorst
High income and wealth inequality corresponds with high rates of various health and social problems. One possible factor that could be contributing to this correlation is stress experienced by those being treated unfairly in an unequal society. The present experiment attempted to simulate aspects of income inequality in a lab setting while recording several measures of stress. Participants (n=96) were assigned to one of four groups and played a memory game against a confederate opponent to earn "money" to spend in a lab market...
August 14, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28818424/interlaboratory-study-for-the-establishment-of-brazilian-bothrops-reference-venom-and-antivenom-for-potency-evaluation-of-bothrops-antivenom
#14
Humberto Pinheiro de Araújo, Elizabeth Porto Reis Lucas, Wlamir Corrêa de Moura, Celia de Fátima Barbosa, Raquel Joane Rodrigues, Josefina Farina Morais, Joseana Zaja Almada, Barbara Carino Guimarães, Antonio Eugenio Castro Cardoso de Almeida, Maria Aparecida Affonso Boller
A collaborative study was performed for the establishment of the 5th lot of Brazilian Bothrops Reference Venom and the 1st lot of Brazilian Bothrops Reference Antivenom. All Brazilian manufacturers of Antibothrops Immunoglobulins and the National Control Laboratory participated of the study. The declared potency of the 5th lot of the Bothrops Reference Venom is 40.29 μg/0.5 ml, and the potency of the 1st lot of Bothrops Reference Antivenom is 6.51 mg/ml. For the potency evaluation of Bothrops Reference Venom the inter assay precision (gCV) was 3...
August 14, 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28817927/identification-of-biosynthetic-gene-clusters-from-metagenomic-libraries-using-pptase-complementation-in-a-streptomyces-host
#15
J Kipchirchir Bitok, Christophe Lemetre, Melinda A Ternei, Sean F Brady
The majority of environmental bacteria are not readily cultured in the lab, leaving the natural products they make inaccessible using culture-dependent discovery methods. Cloning and heterologous expression of DNA extracted from environmental samples (environmental DNA, eDNA) provides a means of circumventing this discovery bottleneck. To facilitate the identification of clones containing biosynthetic gene clusters, we developed a model heterologous expression reporter strain Streptomyces albus::bpsA ΔPPTase...
September 1, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28817258/synthesis-of-complex-glycolates-by-enantioconvergent-addition-reactions
#16
Samuel L Bartlett, Jeffrey S Johnson
The unique role that stereochemistry plays in molecular recognition events continues to provide a driving force for synthesizing organic compounds in enantioenriched form. The tendency of enantioenriched organic compounds to revert to an entropically favored racemic state in the presence of viable racemization pathways (e.g., the enolization of stereogenic carbonyl derivatives) can sometimes interfere with this objective; however, beginning with Noyori's foundational disclosure of a dynamic kinetic transfer hydrogenation, the ability to channel racemic, configurationally labile starting materials through stereoconvergent reaction pathways has been recognized as a powerful strategy in asymmetric synthesis...
August 17, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28816309/reply-to-the-comment-on-towards-a-personalized-approach-to-aromatase-inhibitor-therapy-a-digital-microfluidic-platform-for-rapid-analysis-of-estradiol-in-core-needle-biopsies-by-p-e-l%C3%A3-nning-lab-chip-2017-17-doi-10-1039-c7lc00617a
#17
Robert F Casper, Aaron R Wheeler
This article provides our response to a comment on our article that appeared in Lab on a Chip (S. Abdulwahab, A. H. C. Ng, M. D. Chamberlain, H. Ahmado, L.-A. Behan, H. Gomaa, R. F. Casper and A. R. Wheeler, Lab Chip, 2017, 17, 1594).
August 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28816306/comment-on-towards-a-personalized-approach-to-aromatase-inhibitor-therapy-a-digital-microfluidic-platform-for-rapid-analysis-of-estradiol-in-core-needle-biopsies-by-s-abdulwahab-a-h-c-ng-m-d-chamberlain-h-ahmado-l-a-behan-h-gomaa-r-f-casper-and-a-r-wheeler
#18
Per E Lønning
This comment on an article that appeared in Lab on a Chip (Abdulwahab et al., Lab Chip, 2017, 17, 1594) highlights the need for further validation of the proposed method.
August 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28816259/why-14-ecology-labs-teamed-up-to-watch-grass-grow
#19
Ewen Callaway
No abstract text is available yet for this article.
August 15, 2017: Nature
https://www.readbyqxmd.com/read/28815602/efficacy-and-safety-of-amphotericin-b-formulations-a-network-meta-analysis-and-a-multicriteria-decision-analysis
#20
Fernanda S Tonin, Laiza M Steimbach, Helena H Borba, Andreia C Sanches, Astrid Wiens, Roberto Pontarolo, Fernando Fernandez-Llimos
OBJECTIVES: Despite its broad spectrum, conventional amphotericin B (AB) is associated with serious adverse events. Lipid-based formulations may offer safer options. We aimed to synthesize the evidence of efficacy and safety of AB formulations. METHODS: We performed a systematic review and network meta-analysis (NMA) to compare all available formulations: conventional AB; lipid complex or ABLC; colloidal dispersion or ABCD; liposomal or LAB; AB in Intralipid. Randomized controlled trials were searched in four databases...
August 17, 2017: Journal of Pharmacy and Pharmacology
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