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Bracca 1

DarĂ­o A Bianchi, Guillermo Schmeda Hirschmann, Cristina Theoduloz, Andrea B J Bracca, Teodoro S Kaufman
The synthesis of simplified analogs of the novel isoquinoline alkaloid stephaoxocanidine, carrying the oxazaphenalene ABC-ring system of the natural product, and their activity as inhibitors of the enzyme acetylcholinesterase, are reported. 5,6-Dimethoxy-7H -8-oxa-1-aza-phenalen-9-one (5) was as active as a Narcissus extract enriched in galantamine.
June 2, 2005: Bioorganic & Medicinal Chemistry Letters
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