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Arthropathy

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https://www.readbyqxmd.com/read/28097249/application-of-a-3d-custom-printed-patient-specific-spinal-implant-for-c1-2-arthrodesis
#1
Kevin Phan, Alessandro Sgro, Monish M Maharaj, Paul D'Urso, Ralph J Mobbs
The study aims to describe a three-dimensional printed (3DP) posterior fixation implant used for C1/C2 fusion in a 65-year-old female. Spinal fusion remains a common intervention for a range of spinal pathologies including degenerative disc and facet disease when conservative methods are unsuccessful. However, fusion devices are not always entirely efficacious in providing the desired fixation, and surgeons rely on 'off the shelf' implants which may not provide an anatomical fit to address the particular pathology...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28091549/urinary-proteomics-can-define-distinct-diagnostic-inflammatory-arthritis-subgroups
#2
Stefan Siebert, Duncan Porter, Caron Paterson, Rosie Hampson, Daniel Gaya, Agnieszka Latosinska, Harald Mischak, Joost Schanstra, William Mullen, Iain McInnes
Current diagnostic tests applied to inflammatory arthritis lack the necessary specificity to appropriately categorise patients. There is a need for novel approaches to classify patients with these conditions. Herein we explored whether urinary proteomic biomarkers specific for different forms of arthritis (rheumatoid arthritis (RA), psoriatic arthritis (PsA), osteoarthritis (OA)) or chronic inflammatory conditions (inflammatory bowel disease (IBD)) can be identified. Fifty subjects per group with RA, PsA, OA or IBD and 50 healthy controls were included in the study...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091407/clinical-characteristics-of-patients-with-drug-induced-liver-injury
#3
Li-Xia Yang, Cheng-Yuan Liu, Lun-Li Zhang, Ling-Ling Lai, Ming Fang, Chong Zhang
BACKGROUND: Drug is an important cause of liver injury and accounts for up to 40% of instances of fulminant hepatic failure. Drug-induced liver injury (DILI) is increasing while the diagnosis becomes more difficult. Though many drugs may cause DILI, Chinese herbal medicines have recently emerged as a major cause due to their extensive use in China. We aimed to provide drug safety information to patients and health carers by analyzing the clinical and pathological characteristics of the DILI and the associated drug types...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28088248/the-spectrum-of-rheumatic-in-patient-diagnoses-at-a-pediatric-hospital-in-kenya
#4
Angela Migowa, Inés Colmegna, Carol Hitchon, Eugene Were, Evelyn Ng'ang'a, Thomas Ngwiri, John Wachira, Sasha Bernatsky, Rosie Scuccimarri
BACKGROUND: Pediatric rheumatic diseases are chronic illnesses that can cause considerable disease burden to children and their families. There is limited epidemiologic data on these diseases in East Africa. The aim of this study was to assess the spectrum of pediatric rheumatic diagnoses in an in-patient setting and determine the accuracy of ICD-10 codes in identifying these conditions. METHODS: Medical records from Gertrude's Children's Hospital in Kenya were reviewed for patients diagnosed with "diseases of the musculoskeletal system and connective tissue" as per ICD-10 diagnostic codes assigned at discharge between January and December 2011...
January 14, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28076600/use-of-cuff-tear-arthroplasty-head-prosthesis-for-rotator-cuff-arthropathy-treatment-in-elderly-patients-with-comorbidities
#5
Cassiano Diniz Carvalho, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman
Objective: To evaluate the clinical and functional behavior of patients undergoing cuff tear arthroplasty at different stages of the disease. Methods: Cuff tear arthroplasty hemiarthroplasties were performed in 34 patients with rotator cuff arthropathy and associated comorbidities, classified according to Seebauer. The mean age was 76.3 years, and the sample comprised 23 females (67.6%) and 11 males (32.4%). The mean follow-up period was 21.7 months, and evaluations were performed using the Visual Analog Scale for pain and the Constant scale...
October 2016: Einstein
https://www.readbyqxmd.com/read/28071847/hindfoot-fusion-in-haemophilic-arthropathy-6-year-mean-follow-up-of-41-procedures-performed-in-28-adult-patients
#6
M Brkljac, S Shah, C Hay, E C Rodriguez-Merchan
INTRODUCTION: Haemophilic arthropathy of the ankle is rare disorder caused by recurrent haemarthorses beginning in early adulthood. AIM: Our aim was to evaluate the fusion rate of various techniques of hindfoot fusion using internal fixation for the treatment of haemophilic arthropathy of the hindfoot. METHODS: We have evaluated the fusion rate of various techniques of hindfoot (tibiotalar and subtalar joints) fusion for the treatment of haemophilic arthropathy of the hindfoot...
March 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
https://www.readbyqxmd.com/read/28054948/rs657075-csf2-is-associated-with-the-disease-phenotype-bas-g-of-ankylosing-spondylitis
#7
Wei-Chiao Chen, James Cheng-Chung Wei, Hsing-Fang Lu, Henry Sung-Ching Wong, Peng Yeong Woon, Yu-Wen Hsu, Jin-Ding Huang, Wei-Chiao Chang
Ankylosing spondylitis (AS) is a systemic autoimmune disease mainly affecting the lumbar spine and sacroiliac joints, and exhibits peripheral inflammatory arthropathy. More than 25 loci have been identified as associated with AS. Because both AS and rheumatoid arthritis (RA) are autoimmune diseases that may share some common genetic factors, we therefore examined if the newly identified RA genetic polymorphisms were associated with AS in a Taiwanese population. In this study, we enrolled 475 AS patients and 11,301 healthy subjects from a Taiwanese biobank as controls...
January 3, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28031030/outcome-after-protected-full-weightbearing-treatment-in-an-orthopedic-device-in-diabetic-neuropathic-arthropathy-charcot-arthropathy-a-comparison-of-unilaterally-and-bilaterally-affected-patients
#8
Niklas Renner, Stephan Hermann Wirth, Georg Osterhoff, Thomas Böni, Martin Berli
BACKGROUND: Charcot neuropathic arthropathy (CN) is a chronic, progressive, destructive, non-infectious process that most frequently affects the bone architecture of the foot in patients with sensory neuropathy. We evaluated the outcome of protected weightbearing treatment of CN in unilaterally and bilaterally affected patients and secondarily compared outcomes in protected versus unprotected weightbearing treatment. METHODS: Patient records and radiographs from 2002 to 2012 were retrospectively analyzed...
December 29, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28028161/cartilage-biomarkers-in-the-osteoarthropathy-of-alkaptonuria-reveal-low-turnover-and-accelerated-ageing
#9
Adam M Taylor, Ming-Feng Hsueh, Lakshminarayan R Ranganath, James A Gallagher, Jane P Dillon, Janet L Huebner, Jon B Catterall, Virginia B Kraus
OBJECTIVE: Alkaptonuria (AKU) is a rare autosomal recessive disease resulting from a single enzyme deficiency in tyrosine metabolism. As a result, homogentisic acid cannot be metabolized, causing systemic increases. Over time, homogentisic acid polymerizes and deposits in collagenous tissues, leading to ochronosis. Typically, this occurs in joint cartilages, leading to an early onset, rapidly progressing osteoarthropathy. The aim of this study was to examine tissue turnover in cartilage affected by ochronosis and its role in disease initiation and progression...
January 2017: Rheumatology
https://www.readbyqxmd.com/read/28018094/a-rare-case-of-idiopathic-thumb-cmc-joint-neuropathic-arthropathy-complicated-by-blunt-trauma
#10
Manavdeep Singh, R R Butala, R G Khedekar, Manish Tripati
Neuropathic arthropathy (Charcot joints), which most frequently affects the weight-bearing joints of the body, is commonly associated with a variety of medical and neurological conditions, and is notoriously difficult to treat due to the nature of the underlying pathology. We present a case of idiopathic neuropathic arthropathy of the thumb CMC joint of an elderly female complicated by blunt trauma to the thumb. To our knowledge, this is the first reported case in the literature of this rare association.
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28005111/instability-after-reverse-total-shoulder-arthroplasty-which-patients-dislocate
#11
Eric M Padegimas, Benjamin M Zmistowski, Camilo Restrepo, Joseph A Abboud, Mark D Lazarus, Matthew L Ramsey, Gerald R Williams, Surena Namdari
Given the increasing use of reverse total shoulder arthroplasty (RTSA), it is important to study the complications associated with this procedure. We conducted a study of the incidence, predisposing factors, and treatment of RTSA dislocations. Using our institutional database, we retrospectively searched for RTSAs performed between September 27, 2010 and December 31, 2013 and identified postoperative dislocations. Four hundred eighty-seven patients underwent 510 RTSAs (393 primary, 117 revision). Fourteen patients had 15 dislocations (5 in primary RTSAs, 10 in revision RTSAs)...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/28002890/do-not-let-gout-apathy-lead-to-gouty-arthropathy
#12
EDITORIAL
John D FitzGerald, Tuhina Neogi, Hyon K Choi
No abstract text is available yet for this article.
December 21, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27994095/diffusion-weighted-imaging-is-a-sensitive-biomarker-of-response-to-biologic-therapy-in-enthesitis-related-arthritis
#13
Timothy J P Bray, Kanimozhi Vendhan, Nicola Ambrose, David Atkinson, Shonit Punwani, Corinne Fisher, Debajit Sen, Yiannis Ioannou, Margaret A Hall-Craggs
OBJECTIVE: The aim was to evaluate diffusion-weighted imaging (DWI) as a tool for measuring treatment response in adolescents with enthesitis-related arthropathy (ERA). METHODS: Twenty-two adolescents with ERA underwent routine MRI and DWI before and after TNF inhibitor therapy. Each patient's images were visually scored by two radiologists using the Spondyloarthritis Research Consortium of Canada system, and sacroiliac joint apparent diffusion coefficient (ADC) and normalized ADC (nADC) were measured for each patient...
December 19, 2016: Rheumatology
https://www.readbyqxmd.com/read/27992683/yearly-trends-in-elective-shoulder-arthroplasty-2005-through-2013
#14
Mark T Dillon, Priscilla H Chan, Maria C S Inacio, Anshuman Singh, Edward H Yian, Ronald A Navarro
OBJECTIVE: The purposes of this study were to evaluate the (1) change in incidence rate of shoulder arthroplasty, the (2) utilization of shoulder arthroplasty for specific indications, and the (3) surgeon volume trends associated with these procedures between 2005 and 2013. METHODS: A population based cohort study was conducted using the over 7 million members of an integrated healthcare system in California. Shoulder arthroplasty cases performed between 2005 and 2013 were identified using a Shoulder Arthroplasty Registry...
December 19, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27992070/exercise-for-haemophilia
#15
REVIEW
Karen Strike, Kathy Mulder, Rojer Michael
BACKGROUND: Haemophilia is a bleeding disorder associated with haemorrhaging into joints and muscles. Exercise is often used to aid recovery after bleeds, and to improve joint function in the presence of arthropathy. OBJECTIVES: Our objective was to systematically review the available evidence on the safety and effectiveness of exercise for people with haemophilia. SEARCH METHODS: We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Coagulopathies Trials Register and electronic databases PubMed, OVID-Embase, and CINAHL...
19, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27990383/biologics-use-in-indian-psoriasis-patients
#16
Murlidhar Rajagopalan, Asit Mital
The biologics currently in use for psoriasis in India are etanercept, infliximab and recently introduced itolizumab and secukinumab. Biosimilars, expected to play a significant role in psoriasis management in future, have also been available for the last few years. Patients with psoriasis may be considered eligible to receive treatment with any of the licensed biologic interventions when they fulfill the eligibility criteria. The decision to proceed with treatment must be made in collaboration with the patient and include a careful assessment of the associated risks and benefits...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27976591/efficacy-of-pulsed-high-intensity-laser-therapy-on-pain-functional-capacity-and-gait-in-children-with-haemophilic-arthropathy
#17
Shamekh Mohamed El-Shamy, Ashraf Abdelaal Mohamed Abdelaal
AIM: The aim of this study was to evaluate the effects of pulsed high-intensity laser therapy (HILT) on pain, functional capacity, and gait in children with haemophilia. METHODS: Thirty children with haemophilia type A with ages ranging from 9 to 13 years were selected for this study. They were assigned randomly, into two equal treatment groups. The laser group received the traditional physical therapy programme plus active laser (total energy of 1500 J through three phases/3 sessions/week), whereas the placebo group received the same physical therapy programme plus placebo laser over three consecutive months...
December 15, 2016: Disability and Rehabilitation
https://www.readbyqxmd.com/read/27974218/an-nlrp3-mutation-causes-arthropathy-and-osteoporosis-in-humanized-mice
#18
John N Snouwaert, MyTrang Nguyen, Peter W Repenning, Rebecca Dye, Eric W Livingston, Martina Kovarova, Sheryl S Moy, Brian E Brigman, Ted A Bateman, Jenny P-Y Ting, Beverly H Koller
The NLRP3 inflammasome plays a critical role in host defense by facilitating caspase I activation and maturation of IL-1β and IL-18, whereas dysregulation of inflammasome activity results in autoinflammatory disease. Factors regulating human NLRP3 activity that contribute to the phenotypic heterogeneity of NLRP3-related diseases have largely been inferred from the study of Nlrp3 mutant mice. By generating a mouse line in which the NLRP3 locus is humanized by syntenic replacement, we show the functioning of the human NLRP3 proteins in vivo, demonstrating the ability of the human inflammasome to orchestrate immune reactions in response to innate stimuli...
December 13, 2016: Cell Reports
https://www.readbyqxmd.com/read/27971502/clinical-and-economic-impact-of-the-use-of-infliximab-biosimilar-inflectra-in-rheumatoid-arthritis-psoriatic-arthropathy-and-ankylosing-spondylitis-patients
#19
J Borras Blasco, A Gracia-Pérez, D Casterá, D Rosique-Robles, J Abad, H Heskouri Benlemlih
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27943552/usefulness-of-a-simple-self-administered-joint-condition-assessment-sheet-to-predict-the-need-for-orthopaedic-intervention-in-the-management-of-haemophilic-arthropathy
#20
T Masaoka, K Amano, H Takedani, T Suzuki, M Otaki, I Seita, T Tateiwa, T Shishido, K Yamamoto, K Fukutake
INTRODUCTION: Detecting signs of joint deterioration is important for early effective orthopaedic intervention in managing haemophilic arthropathy. AIM: We developed a simple, patient self-administered sheet to evaluate the joint condition, and assessed the predictive ability of this assessment sheet for the need for an orthopaedic intervention. METHODS: This was a single-centre, cross-sectional study. The association between the score of each of the four items of the assessment sheet (bleeding, swelling, pain and physical impairment) and the results of radiological findings and physical examinations based on Haemophilia Joint Health Score 2...
December 11, 2016: Haemophilia: the Official Journal of the World Federation of Hemophilia
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