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Arthropathy

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https://www.readbyqxmd.com/read/29338586/association-of-cxcl13-serum-level-and-ultrasonographic-findings-of-joints-in-patients-with-systemic-lupus-erythematosus-and-jaccoud-s-arthropathy
#1
D Sá Ribeiro, C F Lins, V Galvão, W G Dourado Santos, G Rosa, V Machicado, A L Pedreira, E P da Fonseca, A P Mota Duque Souza, C Baleeiro, L G Ferreira, I Silva de Oliveira, J P Cotrim Gama da Silva, A M Atta, M B Santiago
Objectives The objective of this paper is to perform an ultrasonography (US) analysis of hands and wrists in two groups of patients with systemic lupus erythematosus (SLE), with and without Jaccoud's arthropathy, matched by age and disease duration and to correlate them with levels of CXCL13 clinical features, laboratory tests and disease activity score. Methods Sixty-four patients with SLE were enrolled, 32 with and 32 without Jaccoud's arthropathy. Each patient underwent physical examination, laboratory tests (including CXCL13 by ELISA) and bilateral US...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29334517/the-effect-of-arthropathies-on-illness-perceptions-coping-strategies-outcomes-and-their-changes-over-time-in-patients-with-inflammatory-bowel-disease-a-12-month-follow-up-study
#2
Sanne J H van Erp, Mike van der Have, Herma H Fidder, Désirée van der Heijde, Ron Wolterbeek, Daniel W Hommes, Ad A Kaptein, Andrea E van der Meulen-de Jong
OBJECTIVES: Arthropathies are a common extraintestinal manifestation (EIM) in inflammatory bowel disease (IBD). This study evaluated the differences in illness perceptions, coping strategies, and illness outcomes between patients with IBD with and without arthropathies at baseline and examined changes at 12 months in these variables in patients with arthropathies. METHODS: In total, 204 patients with (n=123) and without (n=81) arthropathies completed questionnaires at baseline and after 1 year, assessing illness perceptions, coping strategies, quality of life, and work and activity impairment...
January 12, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29334292/safety-and-effectiveness-of-fascial-therapy-in-adult-patients-with-hemophilic-arthropathy-a-pilot-study
#3
Elena Donoso-Úbeda, Javier Meroño-Gallut, José Antonio López-Pina, Rubén Cuesta-Barriuso
BACKGROUND: The primary clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Fascial therapy is one of the most used physiotherapy techniques today to improve joint dysfunctions and chronic pain. OBJECTIVE: To assess the safety and efficacy of fascial therapy treatment in patients with hemophilic arthropathy of ankle and knee. DESIGN: Non-randomized, controlled clinical trial...
January 15, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29333789/physical-training-in-a-medical-fitness-room-for-patients-with-chronic-diseases-functional-and-metabolic-outcomes
#4
Oshrat E Tayer-Shifman, Yigal Bar-On, David Pereg, Alon Y Hershko
BACKGROUND: Physical inactivity is a pivotal factor in the development and progression of various chronic diseases. However, most fitness facilities exclude unhealthy individuals. Therefore, an exercise program that admits such patients is imperative. OBJECTIVES: To evaluate the effectiveness of a fitness facility that admits adult subjects with multiple chronic diseases. METHODS: We conducted a retrospective screening of patient records from the Medical Fitness Facility at Meir Medical Center, Israel...
January 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29328034/characteristics-of-articular-syndrome-in-systemic-vasculitis
#5
O Syniachenko, O Khaniukov, Ye Yehudina, H Taktashov, K Gashynova
The purpose of the study - investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as aspects of the arthritis pathogenesis in this category of patients. The study included 525 patients in the ratio of the examined with Henoch-Schonlen purpura, microscopic polyangiitis, cryoglobulinemic vasculitis, polyarteritis nodosa, Takayasu's arteritis, Wegener's granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis Churg-Strauss as a 7:4:3:1:1:1:1...
December 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29320534/the-endothelial-specific-isoform-of-type-xviii-collagen-correlates-to-annual-bleeding-rate-in-haemophilia-patients
#6
Nadja Gad Kjeld, Baolai Hua, Morten Asser Karsdal, Shu Sun, Tina Manon-Jensen
INTRODUCTION: The medical need in the haemophilic (HF) field to reduce bleeding incidents requires measurement of the annual bleeding rate (ABR) in haemophiliacs. Vascular rupture is associated with damage to the vascular endothelium causing exposure of the basement membrane. Endothelial cells and matrix impairment may be associated with joint bleeds and later development of HF arthropathy. Imbalanced extracellular matrix turnover is a central pathological feature in many diseases consequent to epithelial or endothelial cell damage...
2018: PloS One
https://www.readbyqxmd.com/read/29315787/metabolomic-serum-profiling-after-acl-injury-in-rats-a-pilot-study-implicating-inflammation-and-immune-dysregulation-in-post-traumatic-osteoarthritis
#7
Tristan Maerz, Eric Sherman, Michael Newton, Ali Yilmaz, Praveen Kumar, Stewart F Graham, Kevin C Baker
ACL rupture is a major risk factor for post-traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease development. 36 female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament rupture (ACLR) and to three post-injury time points: 72 hours, 4 weeks, 10 weeks (n = 6). Serum was collected and analyzed by 1 H nuclear magnetic resonance (NMR) spectroscopy and combined direct injection and liquid chromatography (LC)-mass spectrometry (MS)/MS (DI-MS)...
January 8, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29315262/intraarticularly-injected-mesenchymal-stem-cells-stimulate-anti-inflammatory-molecules-and-inhibit-pain-related-protein-and-chondrolytic-enzymes-in-a-monoiodoacetate-induced-rat-arthritis-model
#8
Toru Ichiseki, Miyako Shimazaki, Yoshimichi Ueda, Shusuke Ueda, Masanobu Tsuchiya, Daisuke Souma, Ayumi Kaneuji, Norio Kawahara
Persistent inflammation is well known to promote the progression of arthropathy. mesenchymal stem cells (MSCs) have been shown to possess anti-inflammatory properties and tissue differentiation potency. Although the experience so far with the intraarticular administration of mesenchymal stem cell (MSC) to induce cartilage regeneration has been disappointing, MSC implantation is now being attempted using various surgical techniques. Meanwhile, prevention of osteoarthritis (OA) progression and pain control remain important components of the treatment of early-stage OA...
January 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29306376/sonography-guided-lumbar-nerve-and-facet-blocks-the-first-report-of-clinical-outcome-from-iran
#9
H Sadeghian, R Motiei-Langroudi
INTRODUCTION: Nerve root block (NRB) and facet block (FB) are viable options for pain arising from facet and lumbar disc herniation (LDH) not responding to conservative therapy but still not suitable for surgery. Classically, they are performed under fluoroscopy and computed tomography (CT) guidance, which have the disadvantages of radiation exposure and limited accessibility. The aim of this study was to assess the effectiveness of US guided FB and NRB in patients suffering from facet arthropathy and LDH...
February 2018: Radiography
https://www.readbyqxmd.com/read/29299668/the-open-modified-bankart-procedure-long-term-follow-up-a-16-26-year-follow-up-study
#10
Thomas Berendes, Nina Mathijssen, Hennie Verburg, Gerald Kraan
INTRODUCTION: A Bankart procedure is a surgical technique for the repair of recurrent shoulder joint dislocations. This study reports the long-term results of the 'open'-modified Bankart procedure. METHODS: We performed a retrospective cohort study in which patients are studied who had open-modified Bankart surgery for instability problems in the absence of a substantial osseous glenoid defect after a traumatic shoulder dislocation, 16-26 years ago, in a large regional hospital...
January 3, 2018: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29290607/treatment-of-recurrent-anterior-shoulder-instability-with-the-latarjet-or-bristow-procedure-in-older-patients
#11
Philipp Moroder, Victoria Stefanitsch, Alexander Auffarth, Nicholas Matis, Herbert Resch, Fabian Plachel
BACKGROUND: The coracoid transfer procedure is commonly and successfully used to treat shoulder instability in young patients. However, there is concern that the outcome of this procedure might be inferior in older patients because of decreased bone graft quality and the potential concomitant presence of irreparable rotator cuff tears (RCTs). METHODS: All patients older than 40 years treated with a coracoid transfer procedure between 1998 and 2013 because of anterior shoulder instability were included...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29290606/isolated-loss-of-active-external-rotation-a-distinct-entity-and-results-of-l-episcopo-tendon-transfer
#12
Pascal Boileau, Mohammed Baba, Walter B McClelland, Charles-Édouard Thélu, Christophe Trojani, Nicolas Bronsard
BACKGROUND: The purpose of this study was to characterize a subgroup of cuff-deficient patients with isolated loss of active external rotation (ILER) but preserved active elevation and to evaluate the outcomes of the L'Episcopo procedure to restore horizontal muscle balance. METHODS: During a 10-year period, 26 patients (14 men, 12 women) were identified with ILER in the setting of massive irreparable posterosuperior cuff tears. A modified L'Episcopo tendon transfer was performed to restore active external rotation and to improve shoulder function...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29290604/grammont-humeral-design-versus-onlay-curved-stem-reverse-shoulder-arthroplasty-comparison-of-clinical-and-radiographic-outcomes-with-minimum-2-year-follow-up
#13
Giovanni Merolla, Gilles Walch, Francesco Ascione, Paolo Paladini, Elisabetta Fabbri, Antonio Padolino, Giuseppe Porcellini
BACKGROUND: There are few investigations comparing lateralized and medialized reverse total shoulder arthroplasty (RTSA) in patients with cuff tear arthropathy. This study assessed the outcomes of 2 RTSA designs. METHODS: Sixty-eight consecutive cuff tear arthropathy patients (74 shoulders) with a follow-up of at least 24 months received a Grammont or an onlay curved short-stem humeral component, with or without glenoid lateralization; a cementless humeral stem was implanted in >90%...
December 28, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29281739/lower-temperatures-reduce-type-i-interferon-activity-and-promote-alphaviral-arthritis
#14
Natalie A Prow, Bing Tang, Joy Gardner, Thuy T Le, Adam Taylor, Yee S Poo, Eri Nakayama, Thiago D C Hirata, Helder I Nakaya, Andrii Slonchak, Pamela Mukhopadhyay, Suresh Mahalingam, Wayne A Schroder, William Klimstra, Andreas Suhrbier
Chikungunya virus (CHIKV) belongs to a group of mosquito-borne alphaviruses associated with acute and chronic arthropathy, with peripheral and limb joints most commonly affected. Using a mouse model of CHIKV infection and arthritic disease, we show that CHIKV replication and the ensuing foot arthropathy were dramatically reduced when mice were housed at 30°C, rather than the conventional 22°C. The effect was not associated with a detectable fever, but was dependent on type I interferon responses. Bioinformatics analyses of RNA-Seq data after injection of poly(I:C)/jetPEI suggested the unfolded protein response and certain type I interferon responses are promoted when feet are slightly warmer...
December 27, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/29275432/aetiopathogenesis-of-cuff-tear-arthropathy-could-juvenile-joint-laxity-be-considered-a-predisposing-factor
#15
Stefano Gumina, Alessandro Castagna, Vittorio Candela, Teresa Venditto, Giuseppe Giannicola, Mario Borroni, Ciro Villani
PURPOSE: Although many hypotheses have been formulated, aetiopathogenesis of cuff-tear arthropathy (CTA) is still motive for discussion. Since prevalence of CTA is notoriously higher in women, as is joint hypermobility, we hypothesised a possible correlation between the two conditions. METHODS: One hundred thirty-three (n = 133) consecutive patients with glenohumeral osteoarthritis [48 men, 85 women; mean age (SD) 72.32 (7.05)] were divided into two groups: Groups 1 (CTA) and 2 (concentric shoulder arthropathy) comprised 71 (22 men, 49 women) and 62 (26 men, 36 women), respectively...
December 23, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29273388/assessing-glenosphere-position-superior-approach-versus-deltopectoral-for-reverse-shoulder-arthroplasty
#16
William R Aibinder, Nicholas J Clark, Bradley S Schoch, Scott P Steinmann
BACKGROUND: The anterosuperior (AS) approach for reverse total shoulder arthroplasty (RTSA) has been reported as a risk factor for baseplate malposition because of potential difficulty in glenoid exposure. The objective of this study was to compare glenoid baseplate position between the AS and deltopectoral (DP) approaches in relation to the surgeon's experience and to evaluate the effect of placement on clinical outcomes. METHODS: There were 109 shoulders that underwent RTSA for cuff tear arthropathy or osteoarthritis with cuff tearing by a single surgeon...
December 19, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29273131/association-between-atopic-dermatitis-and-serious-cutaneous-multiorgan-and-systemic-infections-in-us-adults
#17
Shanthi Narla, Jonathan I Silverberg
BACKGROUND: Atopic dermatitis (AD) is associated with barrier disruption, immune dysregulation, and immunosuppressing treatments that can increase the association with an unusual number of infections. OBJECTIVE: To determine whether adults with AD have an unusually large number of serious infections and related outcomes. METHODS: Data from the 2002 to 2012 National Inpatient Sample were analyzed, including an approximately 20% sample of all US hospitalizations (n = 72,108,077 adults)...
January 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29261533/intraarticular-triamcinolone-versus-hyaluronate-injections-for-low-back-pain-with-symptoms-suggestive-of-lumbar-zygapophyseal-joint-arthropathy-a-pragmatic-double-blind-randomized-controlled-trial
#18
Thiru M Annaswamy, Corey Armstead, Luke Carlson, Nicholas J Elkins, Denizen Kocak, Samuel M Bierner
OBJECTIVE: To compare hyaluronate to triamcinolone injections in treating chronic low back pain (CLBP) suggestive of lumbar zygopophyseal joint (ZJT) arthropathy. DESIGN: Prospective, double-blind, randomized controlled trial. 30 subjects were randomly assigned to receive bilateral L3-S1 ZJT injections with triamcinolone (KA) or Synvisc-One® (HA). Pain [Visual Analog Scale (VAS)] and Pain Disability Questionnaire (PDQ) scores at 1, 3, and 6-months were evaluated...
December 19, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29259162/type-i-interferon-mediated-autoinflammation-due-to-dnase-ii-deficiency
#19
Mathieu P Rodero, Alessandra Tesser, Eva Bartok, Gillian I Rice, Erika Della Mina, Marine Depp, Benoit Beitz, Vincent Bondet, Nicolas Cagnard, Darragh Duffy, Michael Dussiot, Marie-Louise Frémond, Marco Gattorno, Flavia Guillem, Naoki Kitabayashi, Fabrice Porcheray, Frederic Rieux-Laucat, Luis Seabra, Carolina Uggenti, Stefano Volpi, Leo A H Zeef, Marie-Alexandra Alyanakian, Jacques Beltrand, Anna Monica Bianco, Nathalie Boddaert, Chantal Brouzes, Sophie Candon, Roberta Caorsi, Marina Charbit, Monique Fabre, Flavio Faletra, Muriel Girard, Annie Harroche, Evelyn Hartmann, Dominique Lasne, Annalisa Marcuzzi, Bénédicte Neven, Patrick Nitschke, Tiffany Pascreau, Serena Pastore, Capucine Picard, Paolo Picco, Elisa Piscianz, Michel Polak, Pierre Quartier, Marion Rabant, Gabriele Stocco, Andrea Taddio, Florence Uettwiller, Erica Valencic, Diego Vozzi, Gunther Hartmann, Winfried Barchet, Olivier Hermine, Brigitte Bader-Meunier, Alberto Tommasini, Yanick J Crow
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response, implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the induction of autoinflammation. By systematic screening using a panel of interferon-stimulated genes we identify two siblings and a singleton variably demonstrating severe neonatal anemia, membranoproliferative glomerulonephritis, liver fibrosis, deforming arthropathy and increased anti-DNA antibodies. In both families we identify biallelic mutations in DNASE2, associated with a loss of DNase II endonuclease activity...
December 19, 2017: Nature Communications
https://www.readbyqxmd.com/read/29258867/oxidative-stress-consequences-and-ros-mediated-cellular-signaling-in-rheumatoid-arthritis
#20
REVIEW
Abdul-Rehman Phull, Bakht Nasir, Ihsan Ul Haq, Song Ja Kim
There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of rheumatoid arthritis...
December 16, 2017: Chemico-biological Interactions
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