Read by QxMD icon Read

Scaffold rapid prototyping

Tae Suk Oh, Woo Shik Jeong, Taik Jin Chang, Kyung S Koh, Jong Woo Choi
BACKGROUND: It is difficult to restore original orbital contours because of their complex 3-dimensional structure. Moreover, slight implant malpositioning can result in enophthalmos or other complications. The authors describe our experience of using individualized prebent titanium-Medpor mesh implants and stereolithographic modeling in a series of patients who underwent orbital wall reconstruction. METHODS: A consecutive series of 104 patients with orbital fractures received computer simulation-designed prebent titanium-Medpor mesh implants insertion...
October 14, 2016: Journal of Craniofacial Surgery
Mercedes Vila, Ana García, Alessandra Girotti, Matilde Alonso, Jose Carlos Rodríguez-Cabello, Arlyng González-Vázquez, Josep A Planell, Elisabeth Engel, Julia Buján, Natalio García-Honduvilla, María Vallet-Regí
: The current study reports on the manufacturing by rapid prototyping technique of three-dimensional (3D) scaffolds based on silicon substituted hydroxyapatite with Elastin-like Recombinamers (ELRs) functionalized surfaces. Silicon doped hydroxyapatite (Si-HA), with Ca10(PO4)5.7(SiO4)0.3(OH)1.7h0.3 nominal formula, was surface functionalized with two different types of polymers designed by genetic engineering: ELR-RGD that contain cell attachment specific sequences and ELR-SNA15/RGD with both hydroxyapatite and cells domains that interact with the inorganic phase and with the cells, respectively...
November 2016: Acta Biomaterialia
Jaroslav Čapek, Markéta Machová, Michaela Fousová, Jiří Kubásek, Dalibor Vojtěch, Jaroslav Fojt, Eva Jablonská, Jan Lipov, Tomáš Ruml
Recently, porous metallic materials have been extensively studied as candidates for use in the fabrication of scaffolds and augmentations to repair trabecular bone defects, e.g. in surroundings of joint replacements. Fabricating these complex structures by using common approaches (e.g., casting and machining) is very challenging. Therefore, rapid prototyping techniques, such as selective laser melting (SLM), have been investigated for these applications. In this study, we characterized a highly porous (87 vol...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Wei Xiao, Mohsen Asle Zaeem, B Sonny Bal, Mohamed N Rahaman
There is a clinical need for synthetic bioactive materials that can reliably repair intercalary skeletal tissue loss in load-bearing bones. Bioactive glasses have been investigated as one such material but their mechanical response has been a concern. Previously, we created bioactive silicate glass (13-93) scaffolds with a uniform grid-like microstructure which showed a compressive strength comparable to human cortical bone but a much lower flexural strength. In the present study, finite element modeling (FEM) was used to re-design the scaffold microstructure to improve its flexural strength without significantly lowering its compressive strength and ability to support bone infiltration in vivo...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
N Gómez-Cerezo, S Sánchez-Salcedo, I Izquierdo-Barba, D Arcos, M Vallet-Regí
UNLABELLED: Mesoporous bioactive glass-polycaprolactone (MBG-PCL) scaffolds have been prepared by robocasting, a layer by layer rapid prototyping method, by stacking of individual strati. Each stratus was independently analyzed during the cell culture tests with MC3T3-E1 preosteblast-like cells. The presence of MBG stimulates the colonization of the scaffolds by increasing the cell proliferation and differentiation. MBG-PCL composites not only enhanced pre-osteoblast functions but also allowed cell movement along its surface, reaching the upper stratus faster than in pure PCL scaffolds...
October 15, 2016: Acta Biomaterialia
Heinz C Schröder, Vlad A Grebenjuk, Xiaohong Wang, Werner E G Müller
Since the first description of the silicateins, a group of enzymes that mediate the formation of the amorphous, hydrated biosilica of the skeleton of the siliceous sponges, much progress has been achieved in the understanding of this biomineralization process. These discoveries include, beside the proof of the enzymatic nature of the sponge biosilica formation, the dual property of the enzyme, to act both as a structure-forming and structure-guiding protein, and the demonstration that the initial product of silicatein is a soft, gel-like material that has to undergo a maturation process during which it achieves its favorable physical-chemical properties allowing the development of various technological or medical applications...
2016: Bioinspiration & Biomimetics
Tiago R Correia, Daniela R Figueira, Kevin D de Sá, Sónia P Miguel, Ricardo G Fradique, António G Mendonça, Ilídio J Correia
Nowadays, the incidence of bone disorders has steeply ascended and it is expected to double in the next decade, especially due to the ageing of the worldwide population. Bone defects and fractures lead to reduced patient's quality of life. Autografts, allografts and xenografts have been used to overcome different types of bone injuries, although limited availability, immune rejection or implant failure demand the development of new bone replacements. Moreover, the bacterial colonization of bone substitutes is the main cause of implant rejection...
June 3, 2016: International Journal of Biological Macromolecules
Xi Weihong, Wang Zhen, Zhu Hong-shui, Li Xiaofeng, Xiong Yuanfei
UNLABELLED: OBJECTIVE This study aims to construct a chitosan (CS)-polycaprolactone (PCL)-hydroxyapatite (HA) composite biomimetic scaffold to replace condyle and to explore the tissue engineering applications of condylar. METHODS: A resin mold of the mandibular condyle was prepared by using rapid prototyping techniques. A mandibular condylar integrated biomimetic scaffold model was prepared by solution casting-ice Lek. PCL and CS were mixed at a ratio of 4:1. HA at quality ratios of 40%, 50%, 60%, and 70% was added to groups a, b, c, and d, respectively...
February 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Bon Kang Gu, Dong Jin Choi, Sang Jun Park, Min Sup Kim, Chang Mo Kang, Chun-Ho Kim
The 3-dimensional (3D) printing technologies, referred to as additive manufacturing (AM) or rapid prototyping (RP), have acquired reputation over the past few years for art, architectural modeling, lightweight machines, and tissue engineering applications. Among these applications, tissue engineering field using 3D printing has attracted the attention from many researchers. 3D bioprinting has an advantage in the manufacture of a scaffold for tissue engineering applications, because of rapid-fabrication, high-precision, and customized-production, etc...
2016: Biomaterials Research
Elena Canciani, Claudia Dellavia, Lorena Maria Ferreira, Chiara Giannasi, Daniela Carmagnola, Antonio Carrassi, Anna Teresa Brini
In the study, we assess a rapid prototyped scaffold composed of 30/70 hydroxyapatite (HA) and beta-tricalcium-phosphate (β-TCP) loaded with human adipose-derived stem cells (hASCs) to determine cell proliferation, differentiation toward osteogenic lineage, adhesion and penetration on/into the scaffold.In this in vitro study, hASCs isolated from fat tissue discarded after plastic surgery were expanded, characterized, and then loaded onto the scaffold. Cells were tested for: viability assay (Alamar Blue at days 3, 7 and Live/Dead at day 32), differentiation index (alkaline phosphatase activity at day 14), scaffold adhesion (standard error of the mean analysis at days 5 and 18), and penetration (ground sections at day 32)...
May 2016: Journal of Craniofacial Surgery
Annemie Houben, Jasper Van Hoorick, Jürgen Van Erps, Hugo Thienpont, Sandra Van Vlierberghe, Peter Dubruel
Over the past decades, solid freeform fabrication (SFF) has emerged as the main technology for the production of scaffolds for tissue engineering applications as a result of the architectural versatility. However, certain limitations have also arisen, primarily associated with the available, rather limited range of materials suitable for processing. To overcome these limitations, several research groups have been exploring novel methodologies through which a construct, generated via SFF, is applied as a sacrificial mould for production of the final construct...
April 14, 2016: Annals of Biomedical Engineering
Stephan Hendrikx, Christian Kascholke, Tobias Flath, Dirk Schumann, Mathias Gressenbuch, F Peter Schulze, Michael C Hacker, Michaela Schulz-Siegmund
UNLABELLED: We present a series of organic/inorganic hybrid sol-gel derived glasses, made from a tetraethoxysilane-derived silica sol (100% SiO2) and oligovalent organic crosslinkers functionalized with 3-isocyanatopropyltriethoxysilane. The material was susceptible to heat sterilization. The hybrids were processed into pore-interconnected scaffolds by an indirect rapid prototyping method, described here for the first time for sol-gel glass materials. A large panel of polyethylene oxide-derived 2- to 4-armed crosslinkers of molecular weights ranging between 170 and 8000Da were incorporated and their effect on scaffold mechanical properties was investigated...
April 15, 2016: Acta Biomaterialia
R Fradique, T R Correia, S P Miguel, K D de Sá, D R Figueira, A G Mendonça, I J Correia
The incidence of bone disorders, whether due to trauma or pathology, has been trending upward with the aging of the worldwide population. The currently available treatments for bone injuries are rather limited, involving mainly bone grafts and implants. A particularly promising approach for bone regeneration uses rapid prototyping (RP) technologies to produce 3D scaffolds with highly controlled structure and orientation, based on computer-aided design models or medical data. Herein, tricalcium phosphate (TCP)/alginate scaffolds were produced using RP and subsequently their physicochemical, mechanical and biological properties were characterized...
April 2016: Journal of Materials Science. Materials in Medicine
Sang Jin Lee, Donghyun Lee, Taek Rim Yoon, Hyung Keun Kim, Ha Hyeon Jo, Ji Sun Park, Jun Hee Lee, Wan Doo Kim, Il Keun Kwon, Su A Park
UNLABELLED: For tissue engineering, a bio-porous scaffold which is applied to bone-tissue regeneration should provide the hydrophilicity for cell attachment as well as provide for the capability to bind a bioactive molecule such as a growth factor in order to improve cell differentiation. In this work, we prepared a three-dimensional (3D) printed polycaprolactone scaffold (PCLS) grafted with recombinant human bone morphogenic protein-2 (rhBMP2) attached via polydopamine (DOPA) chemistry...
August 2016: Acta Biomaterialia
G López-Calzada, A R Hernandez-Martínez, M Cruz-Soto, M Ramírez-Cardona, D Rangel, G A Molina, G Luna-Barcenas, M Estevez
Despite the significant advances in the meniscus tissue engineering field, it is difficult to recreate the complex structure and organization of the collagenous matrix of the meniscus. In this work, we developed a meniscus prototype to be used as substitute or scaffold for the regeneration of the meniscal matrix, recreating the differential morphology of the meniscus by electrospinning. Synthetic biocompatible polymers were combined with the extracellular matrix component, collagen and used to replicate the meniscus...
April 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Bibi Safia Haq, Hidayat Ullah Khan, Khan Alam, Shahnaz Attaullah, Mamoona Sultan
Two-photon polymerization (TPP) has been employed to generate deep structures using the biocompatible and optically transparent monomer ethoxylated bisphenol A dimethacrylate (EO=6) (EBPADMA) and 4, 4'-Bis(diethylamino)benzophenon as the photoinitiator. The two-photon absorption cross section of the initiator was measured to be 1 GM (1  GM=1×10(-50)  cm(4) s photon(-1)) in EBPADMA. Here we have explored a weak absorption regime whereby deep structures (∼300  μm) can be generated in a single pass...
January 10, 2016: Applied Optics
Daniela Steffens, Rodrigo Alvarenga Rezende, Bruna Santi, Frederico David Alencar de Sena Pereira, Paulo Inforçatti Neto, Jorge Vicente Lopes da Silva, Patricia Pranke
INTRODUCTION: Tissue engineering is a field which is currently under a great deal of investigation for the development and/or restoration of tissue and organs, through the combination of cell therapy with biomaterials. Rapid prototyping or additive manufacturing is a versatile technology which makes possible the fabrication of three dimensional (3D) structures from a wide range of materials with complex geometry and accuracy, such as scaffolds. AIM: The aim of this study has been to investigate the interaction between mesenchymal stem cells with poly (ε-caprolactone) (PCL) biomaterials used for obtaining scaffolds through additive manufacturing...
January 2016: Journal of Applied Biomaterials & Functional Materials
Ana I Gonçalves, Márcia T Rodrigues, Pedro P Carvalho, Manuel Bañobre-López, Elvira Paz, Paulo Freitas, Manuela E Gomes
The application of magnetic nanoparticles (MNPs) in tissue engineering (TE) approaches opens several new research possibilities in this field, enabling a new generation of multifunctional constructs for tissue regeneration. This study describes the development of sophisticated magnetic polymer scaffolds with aligned structural features aimed at applications in tendon tissue engineering (TTE). Tissue engineering magnetic scaffolds are prepared by incorporating iron oxide MNPs into a 3D structure of aligned SPCL (starch and polycaprolactone) fibers fabricated by rapid prototyping (RP) technology...
January 21, 2016: Advanced Healthcare Materials
Artem B Kutikov, Kevin A Reyer, Jie Song
Biodegradable polymer/hydroxyapatite (HA) composites are desired for skeletal tissue engineering. When engineered with thermal-responsive shape memory properties, they may be delivered in a minimally invasive temporary shape and subsequently triggered to conform to a tissue defect. Here we report the shape memory properties of thermoplastic amphiphilic poly(D,L-lactic acid-co-ethylene glycol-co-D,L-lactic acid) (PELA, 120 kDa) and HA-PELA composites. These materials can be cold-deformed and stably fixed into temporary shapes at room temperature and undergo rapid shape recovery (< 3 s) at 50 °C...
December 2014: Macromolecular Chemistry and Physics
Jianghong Huang, Jianyi Xiong, Jianquan Liu, Weimin Zhu, Jielin Chen, Li Duan, Jufeng Zhang, Daping Wang
To determine the optimal ratio of nano-hydroxyapatite (n-HA) to polylactic acid (PLLA) in the novel three-dimensional porous PLLA/n-HA composite scaffolds, low-temperature rapid prototyping technology was employed to fabricate the composite materials with different n-HA contents. Mechanical properties and degradation behaviors of the composites were examined, and the scaffold microstructure and n-HA dispersion were observed by scanning electron microscope (SEM). Mechanical tests demonstrated that the tensile strength of the composite material gradually decreased with an increase in n-HA content...
2015: Bio-medical Materials and Engineering
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"