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Scaffold rapid prototyping

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https://www.readbyqxmd.com/read/29778901/3d-printed-drug-delivery-and-testing-systems-a-passing-fad-or-the-future
#1
Seng Han Lim, Himanshu Kathuria, Justin Jia Yao Tan, Lifeng Kang
The US Food and Drug Administration approval of the first 3D printed tablet in 2015 has ignited growing interest in 3D printing, or additive manufacturing (AM), for drug delivery and testing systems. Beyond just a novel method for rapid prototyping, AM provides key advantages over traditional manufacturing of drug delivery and testing systems. These includes the ability to fabricate complex geometries to achieve variable drug release kinetics; ease of personalising pharmacotherapy for patient and lowering the cost for fabricating personalised dosages...
May 17, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29679321/low-temperature-deposition-modeling-of-%C3%AE-tcp-scaffolds-with-controlled-bimodal-porosity
#2
E Papastavrou, P Breedon, D Fairhurst
Low-temperature deposition modeling (LDM), otherwise termed freeze-form extrusion fabrication or rapid freeze prototyping, involves dispensing an aqueous-based ceramic paste or polymeric hydrogel along predefined paths in subzero ambient temperatures, followed by freeze-drying. The solidification of the material after the deposition of each layer enables large parts to be built without the need for organic binders, which can often have cytotoxic effects. Freeze-dried parts obtained from LDM typically exhibit pores with openings that range in average between 1 and 40 μm...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29665336/degradable-3d-printed-hydrogels-based-on-star-shaped-copolypeptides
#3
Robert Murphy, David P Walsh, Charles A Hamilton, Sally-Ann Cryan, Marc In Het Panhuis, Andreas Heise
We present a star copolypeptide based hydrogel ink capable of structural microfabrication using 3D extrusion printing. The material comprises an amphiphilic block copolymer structure of poly(benzyl-L-glutamate-b-L-valine), which spontaneously form hydrogels through hydrophobic interaction. The chemical design allows the bulk phase of the hydrogel to remain intact after application of shear due to its self-recovery behavior. It is demonstrated that the composition of the materials is ideally suited for 3D printing; with scaffolds capable of maintaining structural cohesion after extrusion...
April 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29655516/plga-%C3%AE-tcp-composite-scaffold-incorporating-salvianolic-acid-b-promotes-bone-fusion-by-angiogenesis-and-osteogenesis-in-a-rat-spinal-fusion-model
#4
Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang, Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li, Bo Wei, Wayne Yuk Wai Lee
Spinal disorders often require surgical treatment called spinal fusion to restore a stabilized spine where bone grafts are implanted for the fusion of adjacent vertebras. In this study, we developed a bioactive composite scaffold incorporated with salvianolic acid B (SB), an active component extracted from Danshen. This study aimed to evaluate the effects of SB-incorporated porous scaffold on spinal fusion models. The composite scaffolds composed of poly (lactic-co-glycolic acid) and tricalcium phosphate (PLGA/β-TCP) were fabricated with low-temperature rapid prototyping technique, which incorporated SB at low (SB-L), middle (SB-M), high (SB-H) doses, and pure PLGA/β-TCP as blank control (Con)...
April 4, 2018: Biomaterials
https://www.readbyqxmd.com/read/29608960/update-on-the-main-use-of-biomaterials-and-techniques-associated-with-tissue-engineering
#5
REVIEW
Daniela Steffens, Daikelly I Braghirolli, Natasha Maurmann, Patricia Pranke
Regenerative medicine involves the study of cells, signaling cues and biomatrices to restore normal function of tissues and organs. To develop the matrices for use in tissue engineering there are three main groups of biomaterials: (i) naturally derived materials; (ii) synthetic polymers; and (iii) decellularized organ or tissue scaffolds. These biomaterials, in various forms such as hydrogels, nanofibers and 3D scaffolds, among others, have been employed for different tissue regeneration purposes, with several techniques involved in their production, including rapid prototyping, tissue decellularization and electrospinning...
March 30, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29520139/enhanced-biocompatibility-and-osteogenic-potential-of-mesoporous-magnesium-silicate-polycaprolactone-wheat-protein-composite-scaffolds
#6
Yun Gyeong Kang, Jie Wei, Ji Won Shin, Yan Ru Wu, Jiacan Su, Young Shik Park, Jung-Woog Shin
Background: Successful bone tissue engineering using scaffolds is primarily dependent on the properties of the scaffold, including biocompatibility, highly interconnected porosity, and mechanical integrity. Methods: In this study, we propose new composite scaffolds consisting of mesoporous magnesium silicate (m_MS), polycaprolactone (PCL), and wheat protein (WP) manufactured by a rapid prototyping technique to provide a micro/macro porous structure. Experimental groups were set based on the component ratio: (1) WP0% (m_MS:PCL:WP =30:70:0 weight per weight; w/w); (2) WP15% (m_MS:PCL:WP =30:55:15 w/w); (3) WP30% (m_MS:PCL:WP =30:40:30 w/w)...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29516869/an-antibody-based-approach-for-multi-coloring-osteogenic-and-chondrogenic-proteins-in-tissue-engineered-constructs
#7
Anne M Leferink, Diogo Santos Reis, Clemens A van Blitterswijk, Lorenzo Moroni
When tissue engineering strategies rely on the combination of three-dimensional (3D) polymeric or ceramic scaffolds with cells to culture implantable tissue constructs in vitro, it is desirable to monitor tissue growth and cell fate to be able to more rationally predict the quality and success of the construct upon implantation. Such a 3D construct is often referred to as a 'black-box' since the properties of the scaffolds material limit the applicability of most imaging modalities to assess important construct parameters...
April 11, 2018: Biomedical Materials
https://www.readbyqxmd.com/read/29401707/in-vivo-evaluation-of-3d-printed-polycaprolactone-scaffold-implantation-combined-with-%C3%AE-tcp-powder-for-alveolar-bone-augmentation-in-a-beagle-defect-model
#8
Su A Park, Hyo-Jung Lee, Keun-Suh Kim, Sang Jin Lee, Jung-Tae Lee, Sung-Yeol Kim, Na-Hee Chang, Shin-Young Park
Insufficient bone volume is one of the major challenges encountered by dentists after dental implant placement. This study aimed to evaluate the efficacy of a customized three-dimensional polycaprolactone (3D PCL) scaffold implant fabricated with a 3D bio-printing system to facilitate rapid alveolar bone regeneration. Saddle-type bone defects were surgically created on the healed site after extracting premolars from the mandibles of four beagle dogs. The defects were radiologically examined using computed tomography for designing a customized 3D PCL scaffold block to fit the defect site...
February 4, 2018: Materials
https://www.readbyqxmd.com/read/29316208/effect-of-bone-sialoprotein-coated-three-dimensional-printed-calcium-phosphate-scaffolds-on-primary-human-osteoblasts
#9
Anja Klein, Andreas Baranowski, Ulrike Ritz, Hermann Götz, Sascha Heinemann, Stefan Mattyasovszky, Pol M Rommens, Alexander Hofmann
The combination of the two techniques of rapid prototyping 3D-plotting and bioactive surface functionalization is presented, with emphasis on the in vitro effect of Bone Sialoprotein (BSP) on primary human osteoblasts (hOBs). Our primary objective was to demonstrate the BSP influence on the expression of distinctive osteoblast markers in hOBs. Secondary objectives included examinations of the scaffolds' surface and the stability of BSP-coating as well as investigations of cell viability and proliferation. 3D-plotted calcium phosphate cement (CPC) scaffolds were coated with BSP via physisorption...
January 9, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29225769/fabrication-of-low-cost-micropatterned-polydimethyl-siloxane-scaffolds-to-organise-cells-in-a-variety-of-two-dimensioanl-biomimetic-arrangements-for-lab-on-chip-culture-platforms
#10
Lidia Escutia-Guadarrama, Genaro Vázquez-Victorio, David Martínez-Pastor, Brenda Nieto-Rivera, Marcela Sosa-Garrocho, Marina Macías-Silva, Mathieu Hautefeuille
We present the rapid-prototyping of type I collagen micropatterns on poly-dimethylsiloxane substrates for the biomimetic confinement of cells using the combination of a surface oxidation treatment and 3-aminopropyl triethoxysilane silanisation followed by glutaraldehyde crosslinking. The aim of surface treatment is to stabilise microcontact printing transfer of this natural extracellular matrix protein that usually wears out easily from poly-dimethylsiloxane, which is not suitable for biomimetic cell culture platforms and lab-on-chip applications...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/29131300/engineered-scaffolds-and-cell-based-therapy-for-periodontal-regeneration
#11
REVIEW
Daniela Carmagnola, Mihai Tarce, Claudia Dellavia, Lia Rimondini, Elena M Varoni
BACKGROUND: The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. METHODS: A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies...
November 10, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29046717/designing-of-pla-scaffolds-for-bone-tissue-replacement-fabricated-by-ordinary-commercial-3d-printer
#12
Aleš Gregor, Eva Filová, Martin Novák, Jakub Kronek, Hynek Chlup, Matěj Buzgo, Veronika Blahnová, Věra Lukášová, Martin Bartoš, Alois Nečas, Jan Hošek
BACKGROUND: The primary objective of Tissue engineering is a regeneration or replacement of tissues or organs damaged by disease, injury, or congenital anomalies. At present, Tissue engineering repairs damaged tissues and organs with artificial supporting structures called scaffolds. These are used for attachment and subsequent growth of appropriate cells. During the cell growth gradual biodegradation of the scaffold occurs and the final product is a new tissue with the desired shape and properties...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/28992487/agnps-decorated-3d-printed-peek-implant-for-infection-control-and-bone-repair
#13
Lijun Deng, Yi Deng, Kenan Xie
Polyetheretherketone (PEEK) is an ideal substitute material for bone tissue engineering, which can avoid the stress shielding phenomenon due to its similar mechanical properties to natural human bone. Complex bone defect and postoperative infection are still two enormous challenges in orthopedic clinics. It's well-known that additive manufacturing possesses the merits of high-precision and rapid prototyping, thus it easily meets the needs of mold processing. In the present study, we developed a novel Ag-decorated 3D printed PEEK via catecholamine chemistry...
December 1, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28927930/biodegradable-and-adjustable-sol-gel-glass-based-hybrid-scaffolds-from-multi-armed-oligomeric-building-blocks
#14
Christian Kascholke, Stephan Hendrikx, Tobias Flath, Dzmitry Kuzmenka, Hans-Martin Dörfler, Dirk Schumann, Mathias Gressenbuch, F Peter Schulze, Michaela Schulz-Siegmund, Michael C Hacker
Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(d,l-lactide) domains was developed and characterized. A series of 18 oligomers (Mn: 1100-3200Da) with different degrees of ethoxylation and varying length of oligoester units was established and chemical composition was determined...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28875099/surface-functionalization-of-3d-printed-plastics-via-initiated-chemical-vapor-deposition
#15
Christine Cheng, Malancha Gupta
3D printing is a useful fabrication technique because it offers design flexibility and rapid prototyping. The ability to functionalize the surfaces of 3D-printed objects allows the bulk properties, such as material strength or printability, to be chosen separately from surface properties, which is critical to expanding the breadth of 3D printing applications. In this work, we studied the ability of the initiated chemical vapor deposition (iCVD) process to coat 3D-printed shapes composed of poly(lactic acid) and acrylonitrile butadiene styrene...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28707508/design-and-fabrication-of-porous-biodegradable-scaffolds-a-strategy-for-tissue-engineering
#16
Vahideh Raeisdasteh Hokmabad, Soodabeh Davaran, Ali Ramazani, Roya Salehi
Current strategies of tissue engineering are focused on the reconstruction and regeneration of damaged or deformed tissues by grafting of cells with scaffolds and biomolecules. Recently, much interest is given to scaffolds which are based on mimic the extracellular matrix that have induced the formation of new tissues. To return functionality of the organ, the presence of a scaffold is essential as a matrix for cell colonization, migration, growth, differentiation and extracellular matrix deposition, until the tissues are totally restored or regenerated...
July 24, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28703833/nanoparticle-cellular-uptake-by-dendritic-wedge-peptides-achieving-single-peptide-facilitated-delivery
#17
Joyce C Breger, Markus Muttenthaler, James B Delehanty, Darren A Thompson, Eunkeu Oh, Kimihiro Susumu, Jeffrey R Deschamps, George P Anderson, Lauren D Field, Scott A Walper, Philip E Dawson, Igor L Medintz
Significant efforts are being undertaken to optimize the cargo carrying capacity and especially the cellular delivery efficiency of functionalized nanoparticles for applications in biological research and pharmacological delivery. One approach to increasing nanoparticle surface cargo display capacity is to decrease the number of moieties required for mediating cellular delivery by improving their efficiency. We describe a series of multivalent cell penetrating peptide (CPP) dendrimers that facilitate rapid cellular delivery of prototypical nanoparticle-semiconductor quantum dots (QDs)...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28629025/polycaprolactone-and-polycaprolactone-ceramic-based-3d-bioplotted-porous-scaffolds-for-bone-regeneration-a-comparative-study
#18
COMPARATIVE STUDY
K K Gómez-Lizárraga, C Flores-Morales, M L Del Prado-Audelo, M A Álvarez-Pérez, M C Piña-Barba, C Escobedo
One of the critical challenges that scaffolding faces in the organ and tissue regeneration field lies in mimicking the structure, and the chemical and biological properties of natural tissue. A high-level control over the architecture, mechanical properties and composition of the materials in contact with cells is essential to overcome such challenge. Therefore, definition of the method, materials and parameters for the production of scaffolds during the fabrication stage is critical. With the recent emergence of rapid prototyping (RP), it is now possible to create three-dimensional (3D) scaffolds with the essential characteristics for the proliferation and regeneration of tissues, such as porosity, mechanical strength, pore size and pore interconnectivity, and biocompatibility...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575964/scaffolds-for-bone-tissue-engineering-state-of-the-art-and-new-perspectives
#19
REVIEW
Livia Roseti, Valentina Parisi, Mauro Petretta, Carola Cavallo, Giovanna Desando, Isabella Bartolotti, Brunella Grigolo
This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28554894/fam60a-defines-a-variant-sin3a-hdac-complex-in-embryonic-stem-cells-required-for-self-renewal
#20
Gundula Streubel, Darren J Fitzpatrick, Giorgio Oliviero, Andrea Scelfo, Bruce Moran, Sudipto Das, Nayla Munawar, Ariane Watson, Kieran Wynne, Gian Luca Negri, Eugene T Dillon, SriGanesh Jammula, Karsten Hokamp, Darran P O'Connor, Diego Pasini, Gerard Cagney, Adrian P Bracken
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we compare the composition of the Sin3a-Hdac complex between pluripotent embryonic stem (ES) and differentiated cells by establishing a method that couples two independent endogenous immunoprecipitations with quantitative mass spectrometry. We define the precise composition of the Sin3a complex in multiple cell types and identify the Fam60a subunit as a key defining feature of a variant Sin3a complex present in ES cells, which also contains Ogt and Tet1...
August 1, 2017: EMBO Journal
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