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Scaffold rapid prototyping

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https://www.readbyqxmd.com/read/29131300/engineered-scaffolds-and-cell-based-therapy-for-periodontal-regeneration
#1
Daniela Carmagnola, Mihai Tarce, Claudia Dellavia, Lia Rimondini, Elena M Varoni
BACKGROUND: The main objective of regenerative periodontal therapy is to completely restore the periodontal tissues lost. This review summarizes the most recent evidence in support of scaffold- and cell-based tissue engineering, which are expected to play a relevant role in next-generation periodontal regenerative therapy. METHODS: A literature search (PubMed database) was performed to analyze more recently updated articles regarding periodontal regeneration, scaffolds and cell-based technologies...
November 10, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29046717/designing-of-pla-scaffolds-for-bone-tissue-replacement-fabricated-by-ordinary-commercial-3d-printer
#2
Aleš Gregor, Eva Filová, Martin Novák, Jakub Kronek, Hynek Chlup, Matěj Buzgo, Veronika Blahnová, Věra Lukášová, Martin Bartoš, Alois Nečas, Jan Hošek
BACKGROUND: The primary objective of Tissue engineering is a regeneration or replacement of tissues or organs damaged by disease, injury, or congenital anomalies. At present, Tissue engineering repairs damaged tissues and organs with artificial supporting structures called scaffolds. These are used for attachment and subsequent growth of appropriate cells. During the cell growth gradual biodegradation of the scaffold occurs and the final product is a new tissue with the desired shape and properties...
2017: Journal of Biological Engineering
https://www.readbyqxmd.com/read/28992487/agnps-decorated-3d-printed-peek-implant-for-infection-control-and-bone-repair
#3
Lijun Deng, Yi Deng, Kenan Xie
Polyetheretherketone (PEEK) is an ideal substitute material for bone tissue engineering, which can avoid the stress shielding phenomenon due to its similar mechanical properties to natural human bone. Complex bone defect and postoperative infection are still two enormous challenges in orthopedic clinics. It's well-known that additive manufacturing possesses the merits of high-precision and rapid prototyping, thus it easily meets the needs of mold processing. In the present study, we developed a novel Ag-decorated 3D printed PEEK via catecholamine chemistry...
October 2, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28927930/biodegradable-and-adjustable-sol-gel-glass-based-hybrid-scaffolds-from-multi-armed-oligomeric-building-blocks
#4
Christian Kascholke, Stephan Hendrikx, Tobias Flath, Dzmitry Kuzmenka, Hans-Martin Dörfler, Dirk Schumann, Mathias Gressenbuch, F Peter Schulze, Michaela Schulz-Siegmund, Michael C Hacker
Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(d,l-lactide) domains was developed and characterized. A series of 18 oligomers (Mn: 1100-3200Da) with different degrees of ethoxylation and varying length of oligoester units was established and chemical composition was determined...
November 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28875099/surface-functionalization-of-3d-printed-plastics-via-initiated-chemical-vapor-deposition
#5
Christine Cheng, Malancha Gupta
3D printing is a useful fabrication technique because it offers design flexibility and rapid prototyping. The ability to functionalize the surfaces of 3D-printed objects allows the bulk properties, such as material strength or printability, to be chosen separately from surface properties, which is critical to expanding the breadth of 3D printing applications. In this work, we studied the ability of the initiated chemical vapor deposition (iCVD) process to coat 3D-printed shapes composed of poly(lactic acid) and acrylonitrile butadiene styrene...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28707508/design-and-fabrication-of-porous-biodegradable-scaffolds-a-strategy-for-tissue-engineering
#6
Vahideh Raeisdasteh Hokmabad, Soodabeh Davaran, Ali Ramazani, Roya Salehi
Current strategies of tissue engineering are focused on the reconstruction and regeneration of damaged or deformed tissues by grafting of cells with scaffolds and biomolecules. Recently, much interest is given to scaffolds which are based on mimic the extracellular matrix that have induced the formation of new tissues. To return functionality of the organ, the presence of a scaffold is essential as a matrix for cell colonization, migration, growth, differentiation and extracellular matrix deposition, until the tissues are totally restored or regenerated...
July 24, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28703833/nanoparticle-cellular-uptake-by-dendritic-wedge-peptides-achieving-single-peptide-facilitated-delivery
#7
Joyce C Breger, Markus Muttenthaler, James B Delehanty, Darren A Thompson, Eunkeu Oh, Kimihiro Susumu, Jeffrey R Deschamps, George P Anderson, Lauren D Field, Scott A Walper, Philip E Dawson, Igor L Medintz
Significant efforts are being undertaken to optimize the cargo carrying capacity and especially the cellular delivery efficiency of functionalized nanoparticles for applications in biological research and pharmacological delivery. One approach to increasing nanoparticle surface cargo display capacity is to decrease the number of moieties required for mediating cellular delivery by improving their efficiency. We describe a series of multivalent cell penetrating peptide (CPP) dendrimers that facilitate rapid cellular delivery of prototypical nanoparticle-semiconductor quantum dots (QDs)...
July 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28629025/polycaprolactone-and-polycaprolactone-ceramic-based-3d-bioplotted-porous-scaffolds-for-bone-regeneration-a-comparative-study
#8
K K Gómez-Lizárraga, C Flores-Morales, M L Del Prado-Audelo, M A Álvarez-Pérez, M C Piña-Barba, C Escobedo
One of the critical challenges that scaffolding faces in the organ and tissue regeneration field lies in mimicking the structure, and the chemical and biological properties of natural tissue. A high-level control over the architecture, mechanical properties and composition of the materials in contact with cells is essential to overcome such challenge. Therefore, definition of the method, materials and parameters for the production of scaffolds during the fabrication stage is critical. With the recent emergence of rapid prototyping (RP), it is now possible to create three-dimensional (3D) scaffolds with the essential characteristics for the proliferation and regeneration of tissues, such as porosity, mechanical strength, pore size and pore interconnectivity, and biocompatibility...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28575964/scaffolds-for-bone-tissue-engineering-state-of-the-art-and-new-perspectives
#9
REVIEW
Livia Roseti, Valentina Parisi, Mauro Petretta, Carola Cavallo, Giovanna Desando, Isabella Bartolotti, Brunella Grigolo
This review is intended to give a state of the art description of scaffold-based strategies utilized in Bone Tissue Engineering. Numerous scaffolds have been tested in the orthopedic field with the aim of improving cell viability, attachment, proliferation and homing, osteogenic differentiation, vascularization, host integration and load bearing. The main traits that characterize a scaffold suitable for bone regeneration concerning its biological requirements, structural features, composition, and types of fabrication are described in detail...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28554894/fam60a-defines-a-variant-sin3a-hdac-complex-in-embryonic-stem-cells-required-for-self-renewal
#10
Gundula Streubel, Darren J Fitzpatrick, Giorgio Oliviero, Andrea Scelfo, Bruce Moran, Sudipto Das, Nayla Munawar, Ariane Watson, Kieran Wynne, Gian Luca Negri, Eugene T Dillon, SriGanesh Jammula, Karsten Hokamp, Darran P O'Connor, Diego Pasini, Gerard Cagney, Adrian P Bracken
Sin3a is the central scaffold protein of the prototypical Hdac1/2 chromatin repressor complex, crucially required during early embryonic development for the growth of pluripotent cells of the inner cell mass. Here, we compare the composition of the Sin3a-Hdac complex between pluripotent embryonic stem (ES) and differentiated cells by establishing a method that couples two independent endogenous immunoprecipitations with quantitative mass spectrometry. We define the precise composition of the Sin3a complex in multiple cell types and identify the Fam60a subunit as a key defining feature of a variant Sin3a complex present in ES cells, which also contains Ogt and Tet1...
August 1, 2017: EMBO Journal
https://www.readbyqxmd.com/read/28488350/cranial-reconstruction-using-allogeneic-mesenchymal-stromal-cells-a-phase-1-first-in-human-trial
#11
David Anthony Morrison, Alan Matthew Kop, Anastasia Nilasaroya, Marian Sturm, Kathryn Shaw, Stephen Honeybul
Cranioplasty is necessary for patients that have undergone craniectomy following trauma, stroke or other causes of elevated intracranial pressure. This study assessed the effectiveness of treating cranial defects with a combination of allogeneic mesenchymal stromal cells (MSC) on a ceramic carrier and polymer scaffold, to produce viable bone and healing of a cranial void. Patients underwent a baseline CT scan for construct design. Two sets of interlocking moulds were 3D-printed to enable shaping of two polymer meshes which formed the boundaries of the construct corresponding to restoration of the skull interna and externa...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28486746/collagen-density-gradient-on-three-dimensional-printed-poly-%C3%AE%C2%B5-caprolactone-scaffolds-for-interface-tissue-engineering
#12
Ugo D'Amora, Matteo D'Este, David Eglin, Fatemeh Safari, Christoph M Sprecher, Antonio Gloria, Roberto De Santis, Mauro Alini, Luigi Ambrosio
The ability to engineer scaffolds that resemble the transition between tissues would be beneficial to improve repair of complex organs, but has yet to be achieved. In order to mimic tissue organization, such constructs should present continuous gradients of geometry, stiffness and biochemical composition. Although the introduction of rapid prototyping or additive manufacturing techniques allows deposition of heterogeneous layers and shape control, the creation of surface chemical gradients has not been explored on three-dimensional (3D) scaffolds obtained through fused deposition modelling technique...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28457187/laser-etched-designs-for-molding-hydrogel-based-engineered-tissues
#13
Fabiola Munarin, Nicholas J Kaiser, Tae Yun Kim, Bum-Rak Choi, Kareen L K Coulombe
Rapid prototyping and fabrication of elastomeric molds for sterile culture of engineered tissues allow for the development of tissue geometries that can be tailored to different in vitro applications and customized as implantable scaffolds for regenerative medicine. Commercially available molds offer minimal capabilities for adaptation to unique conditions or applications versus those for which they are specifically designed. Here we describe a replica molding method for the design and fabrication of poly(dimethylsiloxane) (PDMS) molds from laser-etched acrylic negative masters with ∼0...
May 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28378568/rapid-prototyping-technology-and-its-application-in-bone-tissue-engineering
#14
REVIEW
Bo Yuan, Sheng-Yuan Zhou, Xiong-Sheng Chen
Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. Rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies...
2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28229424/three-dimensional-printed-scaffolds-with-multipotent-mesenchymal-stromal-cells-for-rabbit-mandibular-reconstruction-and-engineering
#15
Dongdong Fang, Michael Roskies, Mohamed-Nur Abdallah, Mohammed Bakkar, Jack Jordan, Li-Chieh Lin, Faleh Tamimi, Simon D Tran
Multipotent mesenchymal stromal cells (MSC) derived from both the bone marrow and adipose tissue possess the ability to differentiate into multiple cell lineages, regulate the immune function by secreting numerous bioactive paracrine factors, and hold great potential in cell therapy and tissue engineering. When combined with three-dimensional (3D) scaffolds, MSC can be used for bone defect reconstruction and engineering. This protocol describes the isolation of bone marrow mesenchymal stromal cells (BMMSC) and adipose-tissue derived stem cells (ADSC) from rabbits for subsequent seeding on tissue-engineered 3D-printed scaffolds and transplantation into a rabbit-model with the goal of repairing large osseous mandibular defects (one quarter of the lower jaw is removed surgically)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28105891/friction-of-sodium-alginate-hydrogel-scaffold-fabricated-by-3-d-printing
#16
Qian Yang, Jian Li, Heng Xu, Shijun Long, Xuefeng Li
A rapid prototyping technology, formed by three-dimensional (3-D) printing and then crosslinked by spraying Ca(2+) solution, is developed to fabricate a sodium alginate (SA) hydrogel scaffold. The porosity, swelling ratio, and compression modulus of the scaffold are investigated. A friction mechanism is developed by studying the reproducible friction behavior. Our results show that the scaffold can have 3-D structure with a porosity of 52%. The degree of swelling of the SA hydrogel scaffold is 8.5, which is nearly the same as bulk SA hydrogel...
January 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28076291/individual-construction-of-freeform-fabricated-polycaprolactone-scaffolds-for-osteogenesis
#17
Lu Liu, Guixin Shi, Ying Cui, Hui Li, Zhengchao Li, Qiangcheng Zeng, Yong Guo
The construction of engineered bone mostly focuses on simulating the extracellular matrix (ECM) for proper biological activity. However, the complexity of architecture and the variability of the mechanical properties of natural bones are related to individual differences in age, nutritional state, mechanical loading and disease status. Defect substitutions should be normed with the host natural bone, balancing architectural and mechanical adaption, as well as biological activity. Using a freeform fabrication (FFF) method, we prepared polycaprolactone (PCL) scaffolds with different architectures...
October 26, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28024607/robust-formulation-for-the-design-of-tissue-engineering-scaffolds-a-comprehensive-study-on-structural-anisotropy-viscoelasticity-and-degradation-of-3d-scaffolds-fabricated-with-customized-desktop-robot-based-rapid-prototyping-drbrp-system
#18
M Enamul Hoque
This study investigates the scaffolds' structural anisotropy (i.e. the effect of loading direction), viscoelasticity (i.e. the effect of cross head speed or strain rate), and the influence of simulated physiological environment (PBS solution at 37°C) on the mechanical properties. Besides, the in vitro degradation study has also been performed that evaluates the effect of variation in material and lay-down pattern on the scaffolds' degradation kinetics in terms of mass loss, and change in morphological and mechanical properties...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28005746/customized-orbital-wall-reconstruction-using-three-dimensionally-printed-rapid-prototype-model-in-patients-with-orbital-wall-fracture
#19
Tae Suk Oh, Woo Shik Jeong, Taik Jin Chang, Kyung S Koh, Jong-Woo Choi
BACKGROUND: It is difficult to restore original orbital contours because of their complex 3-dimensional structure. Moreover, slight implant malpositioning can result in enophthalmos or other complications. The authors describe our experience of using individualized prebent titanium-Medpor mesh implants and stereolithographic modeling in a series of patients who underwent orbital wall reconstruction. METHODS: A consecutive series of 104 patients with orbital fractures received computer simulation-designed prebent titanium-Medpor mesh implants insertion...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27966916/injectable-and-3d-bioprinted-polysaccharide-hydrogels-from-cartilage-to-osteochondral-tissue-engineering
#20
REVIEW
Janani Radhakrishnan, Anuradha Subramanian, Uma Maheswari Krishnan, Swaminathan Sethuraman
Biomechanical performance of functional cartilage is executed by the exclusive anisotropic composition and spatially varying intricate architecture in articulating ends of diarthrodial joint. Osteochondral tissue constituting the articulating ends comprise superfical soft cartilage over hard subchondral bone sandwiching interfacial soft-hard tissue. The shock-absorbent, lubricating property of cartilage and mechanical stability of subchondral bone regions are rendered by extended chemical structure of glycosaminoglycans and mineral deposition, respectively...
January 9, 2017: Biomacromolecules
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