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Tracheal papillomatosis

Helena Ribeiro Fortes, Felipe Mussi von Ranke, Dante Luiz Escuissato, Cesar Augusto Araujo Neto, Gláucia Zanetti, Bruno Hochhegger, Klaus Loureiro Irion, Carolina Althoff Souza, Edson Marchiori
To evaluate the findings on chest CTs in 16 patients (8 men and 8 women) with laryngotracheobronchial papillomatosis. This was a retrospective study involving patients ranging from 2 to 72 years of age. The evaluation of the CT scans was independently performed by two observers, and discordant results were resolved by consensus. The inclusion criteria were presence of abnormalities on the CT scans, and the diagnosis was confirmed by anatomopathological examination of the papillomatous lesions. The most common symptoms were hoarseness, cough, dyspnea, and recurrent respiratory infections...
July 2017: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Q W Yang, W Xu, W Guo, W X Cui, Y R Li, X Y Wang, J Yang, X Y Li
Objective: Juvenile on-set recurrent respiratory papillomatosis (JORRP) can be an aggressive and potentially life-threatening disease. To emphasize the importance of complication prevention in local excision surgery, the single-center experience of RRP treatment in a group of patients with relatively short recurrence-free-interval (>4 times/yrs) was reported. Methods: Data of 49 patients underwent papilloma resection during 2002-2013 were retrospectively analyzed. Combined techniques of laser microsurgery and microdebriders were used to remove papillomas, prevent the formation of scar tissue and improve respiratory distress...
October 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
Simon R Best, Michael Mohr, Karen B Zur
OBJECTIVES/HYPOTHESIS: Aggressive laryngeal, tracheal, and pulmonary papilloma is an extremely challenging clinical problem without proven treatment options. A recent German report documented promising results with systemic bevacizumab. The objective of this study is to report the initial experience of this novel treatment in the United States for recurrent respiratory papillomatosis (RRP). STUDY DESIGN: Cases series. METHODS: Electronic survey of the RRP Task Force of the American Society of Pediatric Otolaryngology, American Broncho-Esophagological Association, and physicians known to the authors to have used systemic bevacizumab for RRP...
October 2017: Laryngoscope
Y F Ding, L Chen, H D Huang, Y C Dong, X P Yao, Y Huang, Q Wang, W Zhang, Q Li, C Bai
Objective: To analyze the clinical features in adults with tracheal neoplasm and to evaluate the efficacy of interventional bronchoscopic treatment. Methods: We retrospectively analyzed the clinical features of 43 adults undergoing therapeutic bronchoscopy for tracheal neoplasm diagnosed in Changhai Hospital affiliated to the Second Military Medical University from January 2004 to July 2014.The degree of stenosis, the grade of dyspnea, and Karnofsky performance status scale were evaluated before and after the last procedure...
June 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
Karen B Zur, Elizabeth Fox
Recurrent laryngeal papillomatosis (RRP) can be a devastating condition for a child to endure, and pulmonary involvement may have terminal consequences. Adjuvant therapies have been trialed and reported over the years; however, these chemotherapy options have not been successful. Bevacizumab (Avastin, Genetech Inc., South San Francisco, CA) is a vascular endothelial factor (VEGF) inhibitor that has shown promise in the management of papillomatosis. Most research has focused on intralesional injections of this antiangiogenic drug...
July 2017: Laryngoscope
Karan Madan, Ashesh Dhungana, Neha Kawatra Madan, Anant Mohan, Vijay Hadda, Rakesh Garg, Deepali Jain, Randeep Guleria
A 30-year-old woman presented with a history of progressive shortness of breath, cough, and hoarseness. Stridor was audible on examination. Chest X-ray showed normal lung fields and contrast-enhanced computed tomography thorax showed lower tracheal occlusion with endoluminal growth. Diagnostic flexible bronchoscopy demonstrated multiple whitish glistening nodules over both vocal cords and lower tracheal occlusion by whitish nodular growth. In view of critical central airway obstruction, rigid bronchoscopy and excision of the lower tracheal growth were performed...
November 2016: Lung India: Official Organ of Indian Chest Society
Satish Kalanjeri, Steve Hoffman, Carol Farver, Francisco Aécio Almeida
No abstract text is available yet for this article.
January 1, 2017: American Journal of Respiratory and Critical Care Medicine
Stalin Vinayagam, Mvs Satya Prakash, Pankaj Kundra, Surianarayana Gopalakrishnan
Endotracheal intubation was successfully accomplished with 70° rigid nasendoscope under video guidance in two patients in whom repeated attempts to secure airway with flexible fibreoptic bronchoscope were unsuccessful. Both patients had compromised airway (laryngeal papillomatosis and a huge thyroid swelling) and were uncooperative. Frova intubating introducer was used along with 70° rigid nasendoscope to accomplish tracheal intubation under video guidance.
July 2016: Indian Journal of Anaesthesia
E S Korovkina, O O Magarshak
A thorough collection of complaints and history data, physical examination, and lung function tests are necessary to confirm the diagnosis of asthma. The latter must be differentiated from different diseases in the majority of patients according to age. Recurrent respiratory papillomatosis is caused by human papillomavirus and involves mainly the upper respiratory tract. The paper describes a case of tracheal papillomatosis concurrent with atopic asthma.
2016: Terapevticheskiĭ Arkhiv
Selmin Karatayli-Ozgursoy, Justin Avery Bishop, Alexander Hillel, Lee Akst, Simon R A Best
AIM: Recurrent respiratory papillomatosis (RRP) is classically described as a benign neoplasm of the larynx caused by the low-risk human papillomavirus (HPV) viral subtypes. Nevertheless, transformation to dysplasia and invasive carcinoma can occur. We aimed to assess the prevalence of dysplasia and carcinoma-ex-papilloma in both adult-onset and juvenile-onset RRP and identify patient risk factors for this dysplastic transformation. MATERIAL AND METHODS: Ten-year retrospective chart review of a tertiary otolaryngology referral center...
March 2016: Annals of Otology, Rhinology, and Laryngology
Chuqin Zhang, Bobei Chen, Benyu Nan, Yingying Chen, Jinjian Gao, Saiyu Huang, Haijie Xiang, Xiao Yu, Xuejun Liu, Baozhen Luo
OBJECTIVE: This study was designed to explore the risk factors associated with severity of juvenile onset recurrent respiratory papillomatosis. METHOD: A retrospective study was conducted to study determinants of severe forms of juvenile recurrent onset respiratory papillomatosis. The patients were separated into different groups based on the onset age, the first recurrence of age, the first recurrence of period, gender and incision of tracheal respectively. The relationship among the lesion severity score,the involvement of the subregion, operation period and the next operation period were also explored...
December 2014: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Fatma Yıldırım, Murat Türk, Sedat Demircan, Nalan Akyürek, Ahmet Selim Yurdakul
Tracheal papilloma (TP) is characterized by papillomatous growth of the bronchial epithelium that involves the trachea as a response to Human Papilloma Virus (HPV) infection. A 40-year-old male, with 3-month history of progressive dyspnea was admitted to our hospital, and there were no any other respiratory symptoms. Physical examination was unremarkable. Chest computed tomography (CT) showed that there was a papillomatous mass at the distal trachea. The lesion occupied 80% of tracheal lumen. This patient received cryotherapy and mechanical debridement under general anesthesia and postoperative pathology showed endotracheal papillomatosis...
2015: Case Reports in Pulmonology
Yang Xiao, Jun Wang, Demin Han, Lijing Ma
OBJECTIVES: To describe an individual with recurrent respiratory papillomatosis that extended into the lung parenchyma and underwent malignant transformation and to discuss the characteristic imaging findings associated with this condition. METHODS: The clinical presentation of an individual with this unusual malignant transformation was reviewed. A literature search was performed to characterize the epidemiology, imaging findings and management of this condition...
July 2015: American Journal of the Medical Sciences
Julie Ahn, Justin A Bishop, Belinda Akpeng, Sara I Pai, Simon R A Best
OBJECTIVE: Identifying effective treatment for papillomatosis is limited by a lack of animal models, and there is currently no preclinical model for testing potential therapeutic agents. We hypothesized that xenografting of papilloma may facilitate in vivo drug testing to identify novel treatment options. METHODS: A biopsy of fresh tracheal papilloma was xenografted into a NOD-scid-IL2Rgamma(null) (NSG) mouse. RESULTS: The xenograft began growing after 5 weeks and was serially passaged over multiple generations...
February 2015: Annals of Otology, Rhinology, and Laryngology
Lamia Jamjoom, Emmanuel C Obusez, Jacobo Kirsch, Thomas Gildea, Tan-Lucien Mohammed
This pictorial essay illustrates, describes, and correlates computed tomographic findings of tracheal neoplasms with fiberoptic bronchoscopy findings. Corresponding computed tomography (CT) and bronchoscopy findings of common primary tracheal neoplasms; squamous cell papilloma, papillomatosis, squamous cell carcinoma, adenoid cystic adenoma, non-Hodgkin׳s lymphoma, and a secondary malignant neoplasm of the trachea; and renal cell carcinoma were correlated.
September 2014: Current Problems in Diagnostic Radiology
Emmanuel C Obusez, Lamia Jamjoom, Jacobo Kirsch, Thomas Gildea, Tan-Lucien Mohammed
To illustrate and describe computed tomographic large airway pathology and correlate with fiberoptic bronchoscopy findings. Commonly encountered diseases of the large airway include tracheobronchial amyloidosis, tracheobronchopathia osteochondroplastica, tracheobronchomegaly, laryngotracheobronchial papillomatosis, relapsing polychondritis, Wegener granulomatosis, sarcoidosis, and tracheal stenosis. Computed tomography manifestations and bronchoscopic findings of these selected large airway diseases are discussed...
September 2014: Current Problems in Diagnostic Radiology
M Grasso, M Remacle, V Bachy, S Van Der Vorst, G Lawson
Recurrent respiratory papillomatosis is a viral-induced disease, associated with exophytic epithelial lesions affecting the upper airways. Problem of treatment is the high recurrence of papilloma growth after surgical removal; therefore, adjuvant therapy schemes have been established. We used cidofovir, 7.5 mg/ml, in adjuvant therapy in the past years. Out of 31 adult patients treated with the drug, 26 (83.9 %) are at the moment in complete response. 19 (73 % of pts with CR) of those 26 patients were cured with a number of injections between 1 and 4 (mean 2...
November 2014: European Archives of Oto-rhino-laryngology
Jagdish Chaturvedi, V Sreenivas, V Hemanth, R Nandakumar
To demonstrate the role of oral acyclovir in monthly regimes after microdebrider assisted excision in 3 patients with adult recurrent respiratory papillomatosis (ARRP). Three patients with ARRP who presented to a tertiary referral hospital in stridor were initially treated with a tracheostomy in order to secure airway. On further evaluation by videolaryngoscopy extensive bilateral laryngeal papillomatosis was noted with history of similar conditions in the past for which they were repeatedly operated. They were admitted and underwent Microlaryngeal surgery and laryngeal microdebrider assisted surgery under general anesthesia...
January 2014: Indian Journal of Otolaryngology and Head and Neck Surgery
Abdul Hamid Alraiyes, Michael S Machuzak, Thomas R Gildea
Respiratory tract infection with human papillomavirus has been associated with major airway complications, including tracheal stenosis. We report a case of recurrent respiratory papillomatosis infection complicated with iatrogenic airway fire injury causing airway stenosis. This was treated with reconstruction and a silicone Y stent placement. Three years after the stent placement, the patient presented with wheezing and shortness of breath. Bronchoscopy revealed tracheal narrowing proximal to the tracheal limb of the Y stent...
October 2013: Journal of Bronchology & Interventional Pulmonology
Zhonglin Hao, Thomas Dillard, Paul Biddinger, Vijay Patel
A 52-year-old non-smoker and renal transplant recipient developed an incessant cough. A CT scan of the thorax revealed ill-defined hazy opacities in the right upper lung. He was diagnosed with non-tuberculosis Mycobacterium chelonae/abscessus infection based on sputum culture results. A trial of antibiotics initially resulted in some clinical improvement. A subsequent CT of the thorax documented worsening of the lesions in the right lung and new lesions on the left. An intratracheal growth was noted. Bronchoscopy with biopsy of the tracheal lesions documented respiratory papillomatosis with transformation to squamous cell cancer...
August 28, 2013: BMJ Case Reports
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