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https://www.readbyqxmd.com/read/28714181/involvement-of-adenosine-triphosphate-binding-cassette-subfamily-b-member-1-in-the-augmentation-of-triacylglycerol-excretion-by-propionibacterium-acnes-in-differentiated-hamster-sebocytes
#1
Koji Mizuno, Noriko Akimoto, Mina Kawamura, Keisuke Nakase, Norihisa Noguchi, Takashi Sato
An onset of acne, a common inflammatory skin disease, is associated with excess sebum production and secretion in sebaceous glands. Because Propionibacterium acnes has been reported to augment intracellular sebum accumulation in sebaceous glands in hamsters, it remains unclear whether P. acnes influences sebum secretion from differentiated sebocytes. Both P. acnes culture media (Acnes73-CM) and formalin-killed P. acnes (F-Acnes73) dose-dependently increased the extracellular levels of triacylglycerol (TG), a major sebum component, and Rhodamine 123, a substrate of adenosine triphosphate-binding cassette (ABC) transporter, from differentiated hamster sebocytes (DHS)...
July 17, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28713602/treatment-of-nonclassic-11-hydroxylase-deficiency-with-ashwagandha-root
#2
Daniel Powell, Taiga Inoue, Gül Bahtiyar, Gabriel Fenteany, Alan Sacerdote
An elderly woman presented with acne and male pattern alopecia, which upon diagnostic evaluation was found to be due to nonclassic 11-hydroxylase deficiency. We previously reported that Ashwagandha root ameliorates nonclassic 3-β-ol dehydrogenase and aldosterone synthase deficiencies. This is the first report of its use being associated with amelioration of nonclassic 11-hydroxylase deficiency, where its apparent effects appear to be dose-related.
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/28712269/acne-fulminans-following-isotretinoine-therapy
#3
Dario Didona, Giovanni Paolino, Carmen Cantisani, Giacomo Viti, Dante R Caposiena Caro, Biagio Didona
No abstract text is available yet for this article.
July 13, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28712017/the-distribution-of-infection-with-propionibacterium-acnes-is-equal-in-patients-with-cervical-and-lumbar-disc-herniation
#4
Naghmeh Javanshir, Firooz Salehpour, Javad Aghazadeh, Farhad Mirzaei, Seyed Ahmad Naseri Alavi
BACKGROUND: Cervical and back pains are important clinical problems affecting human populations globally. It is suggested that Propionibacterium acnes (P. acnes) is associated with disc herniation. The aim of this study is to evaluate the distribution of P. acnes infection in the cervical and lumbar disc material obtained from patients with disc herniation. METHODS AND MATERIAL: A total of 145 patients with mean age of 45.21 ± 11.24 years who underwent micro-discectomy in cervical and lumbar regions were enrolled into the study...
July 15, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28711608/do-anabolic-androgenic-steroids-have-performance-enhancing-effects-in-female-athletes
#5
REVIEW
Grace Huang, Shehzad Basaria
Doping with anabolic androgenic steroids (AAS) is common among both male and female athletes and is a growing public health problem. Review of historical data of systematic state-sponsored doping programs implemented by the German Democratic Republic in elite female athletes and from the clinical trials of testosterone administration in non-athlete women suggests that AAS have ergogenic effects in women. The use of AAS in female athletes has been associated with adverse effects that include acne, hirsutism, deepening of the voice and menstrual disturbances; life-threatening adverse effects such as cardiac arrhythmias and sudden death have also been reported...
July 12, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28710837/quality-of-life-anxiety-prevalence-depression-symptomatology-and-suicidal-ideation-among-acne-patients-in-lithuania
#6
L Lukaviciute, P Navickas, A Navickas, J Grigaitiene, R Ganceviciene, C C Zouboulis
BACKGROUND/OBJECTIVE: We aimed to determine the prevalence of anxiety, depression symptomatology and suicidal ideation among patients with acne and the impact of this skin condition on the quality of life in Lithuania. METHODS: The mental health of patients with acne was assessed using an adapted Hospital Anxiety and Depression Scale, the Dermatology Quality of Life Index, questions about characteristics of acne. The study was authorized by the Regional Biomedical Research Ethics Committee...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28709127/chemometrically-assisted-development-and-validation-of-lc-ms-ms-method-for-the-analysis-of-potential-genotoxic-impurities-in-meropenem-active-pharmaceutical-ingredient
#7
Katerina Grigori, Yannis L Loukas, Anđelija Malenović, Vicky Samara, Anastasia Kalaskani, Efi Dimovasili, Magda Kalovidouri, Yannis Dotsikas
A sensitive Liquid Chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated for the quantitative analysis of three potential genotoxic impurities (318BP, M9, S5) in meropenem Active Pharmaceutical Ingredient (API). Due to the requirement for LOD values in ppb range, a high concentration of meropenem API (30mg/mL) had to be injected. Therefore, efficient determination of meropenem from its impurities became a critical aim of this study, in order to divert meropenem to waste, via a switching valve...
June 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28707712/acne-prevalence-and-associations-with-lifestyle-a-cross-sectional-online-survey-of-adolescents-young-adults-in-7-european-countries
#8
P Wolkenstein, A Machovcová, J C Szepietowski, D Tennstedt, S Veraldi, A Delarue
BACKGROUND: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations. OBJECTIVE: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne. METHODS: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=10,521), identified by a quota sampling method based on age, geographic location, and socio-professional category...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28707651/chemical-environmental-factors-can-they-affect-acne
#9
Maria Mazioti
No abstract text is available yet for this article.
July 14, 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28705050/association-of-isotretinoin-with-depression-and-suicide-a-review-of-current-literature
#10
João Miguel Oliveira, Gonçalo Sobreira, Jorge Velosa, Diogo Telles Correia, Paulo Filipe
Acne vulgaris, a condition that can affect people at any age, is the most common cause of referral to a dermatologist. Isotretinoin (ITT) is the most effective treatment available, but serious adverse effects, including a possible association with depression and suicide, limit its use. We review the current literature regarding the association of ITT with depression and suicide. Case reports and database studies show a clear association, and this association is biologically plausible. Although prospective studies have opposite results, limitations make them unsuitable to identify a subgroup of patients who may be at risk of developing depression or suicidal ideation with ITT...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28704984/the-effect-of-personal-familial-and-enviroinmental-characteristics-on-acne-vulgaris-a-prospective-multicenter-case-controlled-study-from-turkey
#11
Ayşe S Karadağ, İlknur Balta, Hayriye Saricaoğlu, Selim Kiliç, Kıymet H Kelekçi, Mehmet Yildirim, Deniz A Arica, Savaş Öztürk, Göksun Karaman, Aslı A Çerman, Serap G Bilgili, Enver Turan, Mustafa M Demirci, Tuğba K Uzunçakmak, Serdar C Güvenç, Arzu Ataseven, Ayten Ferahbaş, Berna Aksoy, Emine Çölgeçen, Özlem Ekiz, Filiz Topaloğlu Demir, Özlem Bilgiç, Seray Çakmak, Derya Uçmak, Pınar Özuğuz, Yeşim Kaymak Konkuralp, Aylin T Ermertcan, Gonca Gökdemir, Emel Bülbül Başkan, Gökçen Alyamaç, Hatice Şanli
BACKGROUND: There are only a few studies about epidemiological features of acne vulgaris in the literature. The aim of this study was to analyze demographic, clinical, familial and environmental characteristics of acne, the role of diet and aggravating factors and association of these factors with acne severity. METHODS: Patients with a diagnosis of mild-moderate to severe acne were consecutively interviewed at the participating centers during the study period. RESULTS: A total of 3826 patients and 759 control patients were involved in this study...
July 11, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28703244/photoreactions-of-2-furan-2-yl-3-hydroxy-4h-chromen-4-one-and-3-hydroxy-2-thiophene-2-yl-4h-chromen-4-one-using-cyclohexane-and-acetonitrile-as-solvents
#12
Kulvir Kaur, Ranbir Kaur, Jyoti Tomar, Manisha Bansal
Photolysis of the titled chromenones was carried out at their longest absorption band (∼360 nm) using cyclohexane (CH) and acetonitrile (ACN) as solvents, in both aerated and de-aerated solutions. Different dimeric photoproducts were formed with both chromenones in aerated solutions. On photolysing 2-(furan-2-yl)-3-hydroxy-4H-chromen-4-one (FHC) in aerated cyclohexane, 2-(furan-2-yl)-2-{[2-(furan-2yl)-4-oxo-4H-chromen-3-yl]oxy}-2H-chromene-3,4-dione (a dehydrodimer) was formed, and on photolysing 3-hydroxy-2-(thiophene-2-yl)-4H-chromen-4-one (THC) in aerated ACN, a different dimeric product was isolated and identified...
July 13, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28701012/-diagnosis-of-periprosthetic-joint-infection-of-shoulder-arthroplasties
#13
Bernd Fink, Florian Sevelda
Periprosthetic joint infection of shoulder arthroplasties is one of the most frequent reasons for pain and revision surgery of shoulder arthroplasties. Propionibacterium acnes is one of the commonest microorganisms causing periprosthetic joint infection in shoulder arthroplasties. It is difficult to detect this slow growing microorganism. This paper gives an overview of the different diagnostic methods. A combination of unspecific and specific tests (detection of microorganism and sensitivity to antibiotics) is helpful in identifying a periprosthetic shoulder infection...
July 12, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28697465/combined-photodynamic-and-antibiotic-therapy-for-skin-disorder-via-lipase-sensitive-liposomes-with-enhanced-antimicrobial-performance
#14
Songhee Jeong, Jonghwan Lee, Byeong Nam Im, Hyung Park, Kun Na
A lipase-sensitive singlet oxygen-producible and erythromycin-loaded liposome (LSSPL) was developed for combination antibacterial therapy for skin disorder. The LSSPL was synthesized by coating pullulan-pheophorbide a (PU-Pheo A) conjugates onto erythromycin-loaded liposomes composed of 1,2-dipalmitoyl-sn-phosphatidylcholine (DPPC) and cholesterol. Lipase activity was chosen as the environmental-stimulus for the controlled release of erythromycin and Pheo A from LSSPL because skin inflammation-inducing Propionibacterium acnes (P...
July 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28696038/recognizing-syndromic-hidradenitis-suppurativa-a-review-of-the-literature
#15
REVIEW
J Gasparic, P Theut Riis, G B Jemec
BACKGROUND: Hidradenitis suppurativa (HS) is an inflammatory skin disease causing painful inflammation and suppuration. It may occur in rare syndromes: follicular occlusion, Bazex-Dupré-Christol, Down's, KID, PAPASH, PASS, PASH, and SAPHO syndromes, as well as Dowling-Degos disease. An overview of syndromic HS may inform the search for etiological factors in HS. METHODS: Pubmed, Ovid, and Web of Science were systematically searched using "(hidradenitis OR acne invers*) AND (syndrome OR KID OR PASS OR PAPA OR PASH OR SAPHO OR bazex-dupre OR "dowling degos" OR triad OR tetrad)" and Cochrane Library using "hidradenitis OR acne invers*"...
July 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28694086/an-outbreak-of-post-craniotomy-propionibacterium-acnes-infections-at-a-tertiary-hospital-england-2011-a-case-control-study-identifies-dural-implants-as-a-risk-factor-for-infection
#16
Caoimhe McKerr, Nic Coetzee, Obaghe Edeghere, Shakeel Suleman, Neville Q Verlander, Krishna Banavathi
BACKGROUND: In 2011, 15 deep-seated Propionibacterium acnes infections were identified in patients following craniotomies in a hospital in the UK. AIM: To describe the outbreak and report findings from the investigation undertaken in order to identify the source & risk factors and inform control measures. METHODS: Data were obtained from hospital clinical records and included patient and surgical variables. Cases were defined as patients with microbiologically confirmed deep or organ space surgical site infection (SSI) caused by P...
July 7, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28692353/fractional-carbon-dioxide-co2-laser-combined-with-topical-tretinoin-for-the-treatment-of-different-forms-of-cystic-acne
#17
Carmela Pestoni Porvén, Vanessa Vieira Dos Santos, Jesus Del Pozo Losada
Nodulocystic acne is prone to scarring and difficult to treat with treatments other than oral isotretinoin. The aim of this article is to discuss the role of a single session of a fractional CO2 laser combined with a topical treatment with a tretinoin and antibiotic gel for a month as a successful treatment to improve nodulocystic acne and chronic microcystic acne. Two cases were involved: the first with nodulocystic acne lesions that persisted after oral retinoids and the second with chronic microcystic acne resistant to topical treatments...
July 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28691291/eighth-annual-general-meeting-anzup-cancer-trials-group-ltd-anzup-acn-133-634-956
#18
(no author information available yet)
No abstract text is available yet for this article.
July 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28690466/propionibacterium-acnes-host-inflammatory-response-during-periprosthetic-infection-is-joint-specific
#19
Scott R Nodzo, K Keely Boyle, Samrath Bhimani, Thomas R Duquin, Andy O Miller, Geoffrey H Westrich
BACKGROUND: Propionibacterium acnes (P. acnes) has become increasingly recognized as a cause of periprosthetic joint infection (PJI). QUESTIONS/PURPOSES: It is not currently known if the clinical presentation of P. acnes varies depending on the joint being infected. METHODS: We retrospectively reviewed patients infected with P. acnes after total hip, knee, and shoulder arthroplasty from two institutions. Patients were classified as having a PJI based on the Musculoskeletal Infection Society criteria and were excluded if they had a polymicrobial culture...
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28690160/polymer-conjugated-retinoids-for-controlled-transdermal-delivery
#20
Steven A Castleberry, Mohiuddin A Quadir, Malak Abu Sharkh, Kevin E Shopsowitz, Paula T Hammond
All-trans retinoic acid (ATRA), a derivative of vitamin A, is a common component in cosmetics and commercial acne creams as well as being a first-line chemotherapeutic agent. Today, formulations for the topical application of ATRA rely on creams and emulsions to incorporate the highly hydrophobic ATRA drug. These strategies, when applied to the skin, deliver ATRA as a single bolus, which is immediately taken up into the skin and contributes to many of the known adverse side effects of ATRA treatment, including skin irritation and hair loss...
July 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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