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https://www.readbyqxmd.com/read/29161317/evaluating-architecture-impact-on-system-energy-efficiency
#1
Shijie Yu, Hailong Yang, Rui Wang, Zhongzhi Luan, Depei Qian
As the energy consumption has been surging in an unsustainable way, it is important to understand the impact of existing architecture designs from energy efficiency perspective, which is especially valuable for High Performance Computing (HPC) and datacenter environment hosting tens of thousands of servers. One obstacle hindering the advance of comprehensive evaluation on energy efficiency is the deficient power measuring approach. Most of the energy study relies on either external power meters or power models, both of these two methods contain intrinsic drawbacks in their practical adoption and measuring accuracy...
2017: PloS One
https://www.readbyqxmd.com/read/29154836/a-new-promising-simultaneous-approach-for-attenuating-type-ii-diabetes-mellitus-induced-neuropathic-pain-in-rats-inos-inhibition-and-neuroregeneration
#2
Abhilasha Ahlawat, Saurabh Sharma
In view of the pathologic basis for the treatment of diabetic neuropathy, it is important to enhance nerve regeneration as well as prevent nerve degeneration. So, in the present study, we have investigated the effect of S-Methylisothiourea Sulfate (selective iNOS inhibitor) and Citicoline, alone and in combination, on Type II Diabetes Mellitus induced neuropathic pain in wistar rats. Type II diabetes was induced by providing high fat diet and low dose of Streptozotocin for 35 days in rats. Type II Diabetes Mellitus was assessed in terms of increased glucose, triglycerides, cholesterol, LDL levels, glucose tolerance and decrease in HDL levels...
November 14, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29150384/the-effect-of-sensory-motor-training-on-hand-and-upper-extremity-sensory-and-motor-function-in-patients-with-idiopathic-parkinson-disease
#3
Ghorban Taghizadeh, Akram Azad, Sepiede Kashefi, Soheila Fallah, Fatemeh Daneshjoo
STUDY DESIGN: Blinded randomized controlled trial. INTRODUCTION: Patients with Parkinson disease (PD) have sensory problems, but there is still no accurate understanding of the effects of sensory-motor interventions on PD. PURPOSE OF THE STUDY: To investigate the effects of sensory-motor training (SMT) on hand and upper extremity sensory and motor function in patients with PD. METHODS: Forty patients with PD were allocated to the SMT group or the control group (CG) (mean ages ± standard deviation: SMT, 61...
November 14, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/29128557/the-effect-of-diet-adiposity-and-weight-loss-on-the-secretion-of-incretin-hormones-in-cats
#4
K E McCool, A J Rudinsky, V J Parker, C O Herbert, C Gilor
Degree of adiposity and dietary macronutrient composition affect incretin hormone secretion in humans and mice, but little is known about their effect in cats. In this study, 7 overweight cats were fed a maintenance diet (MD) for at least 2 wk followed by a reduced calorie diet (RCD), which was lower in fat and higher in carbohydrates and fiber. Cats were fed ad libitum initially, and then, food was restricted to achieve 1%-2% loss of body weight weekly (11 wk). When lean, cats were fed MD for 2 wk. A standardized meal test (SMT) using a third diet was performed after at least 7 d on each diet, before and after weight loss (four SMT's total)...
October 20, 2017: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29122147/physical-activity-and-psychosocial-function-following-cardiac-rehabilitation-one-year-follow-up-of-the-enhanced-study
#5
Patrick J Smith, Andrew Sherwood, Stephanie Mabe, Lana Watkins, Alan Hinderliter, James A Blumenthal
OBJECTIVE: To examine the long-term association between physical activity (PA) and psychosocial functioning following completion of cardiac rehabilitation (CR) among participants in the ENHANCED study. METHOD: ENHANCED was a 3-month clinical trial examining standard CR with and without stress management training (SMT). Participants completed the Leisure-Time Exercise Questionnaire (LTEQ), Beck Depression Inventory-II (BDI-II), and the Spielberger State-Trait Anxiety Inventory (STAI) at baseline, 3- and 12-months after randomization...
November 2017: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29119499/an-integrative-approach-toward-biology-organisms-and-cancer
#6
Carlos Sonnenschein, Ana M Soto
Over the last two decades, we have challenged the hegemony of the somatic mutation theory of carcinogenesis (SMT) based on the lack of theoretical coherence of the premises adopted by its followers. We offered instead a theoretical alternative, the tissue organization field theory (TOFT), that is based on the premises that cancer is a tissue-based disease and that proliferation and motility is the default state of all cells. We went on to use a theory-neutral experimental protocol that simultaneously tested the TOFT and the SMT...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29111463/diagnostic-validity-of-combining-history-elements-and-physical-examination-tests-for-traumatic-and-degenerative-symptomatic-meniscal-tears
#7
Simon Décary, Michel Fallaha, Pierre Frémont, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Debbie Feldman, Marie-Pierre Sylvestre, Pascal-André Vendittoli, François Desmeules
BACKGROUND: Current approach to the clinical diagnosis of traumatic and degenerative symptomatic meniscal tears (SMT) propose combining history elements and physical examination tests without systematic prescription of imaging investigations, yet the evidence to support this diagnostic approach is scarce. OBJECTIVE: To assess the validity of diagnostic clusters combining history elements and physical examination tests to diagnose or exclude traumatic and degenerative SMT compared to other knee disorders...
October 27, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29106753/salvage-endoscopic-resection-after-chemoradiotherapy-for-esophageal-squamous-cell-carcinoma-what-are-the-risk-factors-for-recurrence-after-salvage-er
#8
Takuya Hombu, Tomonori Yano, Ken Hatogai, Takashi Kojima, Tomohiro Kadota, Masakatsu Onozawa, Yusuke Yoda, Keisuke Hori, Yasuhiro Oono, Hiroaki Ikematsu, Satoshi Fujii
BACKGROUND AND AIMS: Salvage endoscopic resection (ER) is among the curative treatments for superficial local failure after chemoradiotherapy (CRT) for esophageal squamous cell carcinoma (ESCC). This study aimed to clarify risk factors for recurrence after salvage ER. METHODS: This study enrolled consecutive ESCC patients treated with salvage ER for local failure after CRT between 1998 and 2013. Recurrences after salvage ER included locoregional recurrences and distant metastases...
November 6, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29078625/laparoscopic-techniques-and-strategies-for-gastrointestinal-gists
#9
REVIEW
Chang Min Lee, Sungsoo Park
The laparoscopic approach is widely accepted surgical treatment for gastrointestinal submucosal tumors (SMTs). In this chapter, we will introduce laparoscopic techniques and strategy for gastrointestinal SMTs, in accordance with those for gastrointestinal stromal tumors (GISTs). The indication for a laparoscopic approach has been related to tumor size. The upper limit of tumor size has increased, according to recent trends, and there is no established guideline for a lower limit. All patients undergoing laparoscopic surgery receive preoperative examinations including gastrofiberscopy, upper gastrointestinal radiography, computed tomography (CT), and endoscopic ultrasonography (EUS)...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29071866/-antiasthmatic-effects-of-different-tonifying-kidney-yin-formulas-and-their-effects-on-airway-remodeling-in-chronic-asthma
#10
Lei Tong, Lin-Lin Sun, Jin-Li Liu, Yue-Juan Gao
Both of Zuogui Wan(ZGW) and Liuwei Dihuang Wan(LWDHW) contain ingredients of Sanbufang(SBF), which have been proven to have antiasthmatic effects. In order to study the antiasthmatic effects of the three tonifying kidney-Yin formulas and their mechanisms, BALB/c mice were randomly divided into 5 groups. Chronic asthma was induced by ovalbumin. Mice in treated groups were respectively given 49.0 g•kg⁻¹ZGW, 35.0 g•kg⁻¹LWDHW and 22.4 g•kg⁻¹SBF by gavage. Those in normal and model group were given normal saline...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29060149/estimates-of-peak-electric-fields-induced-by-transcranial-magnetic-stimulation-in-pregnant-women-as-patients-using-an-fem-full-body-model
#11
J Yanamadala, G M Noetscher, S N Makarov, A Pascual-Leone
Transcranial magnetic stimulation (TMS) for treatment of depression during pregnancy is an appealing alternative to fetus-threatening drugs. However, no studies to date have been performed that evaluate the safety of TMS for a pregnant mother patient and her fetus. A full-body FEM model of a pregnant woman with about 100 tissue parts has been developed specifically for the present study. This model allows accurate computations of induced electric field in every tissue given different locations of a shape-eight coil, a biphasic pulse, common TMS pulse durations, and using different values of the TMS intensity measured in SMT (Standard Motor Threshold) units...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053486/retrospective-analysis-of-sinus-membrane-thickening-profile-causal-factors-and-its-influence-on-complications
#12
Hyun-Chang Lim, Ji-Yeon Nam, Jae-Kook Cha, Jung-Seok Lee, Dong-Woon Lee, Ui-Won Jung, Seong-Ho Choi
PURPOSE: To retrospectively determine the profile of the sinus membrane (SM), potential factors affecting SM thickening (SMT), and the correlation between SMT and sinus augmentation (SA) complications. MATERIALS AND METHODS: In the patients who received lateral SA, SMT was classified in sagittal sections of cone-beam computed tomography according to its thickness and morphology. The correlation between SMT and the following factors was analyzed: age, sex, endodontic and periodontic statuses of neighboring teeth, and shape of the sinus inferior border...
October 17, 2017: Implant Dentistry
https://www.readbyqxmd.com/read/29044466/massage-therapy-decreases-cancer-related-fatigue-results-from-a-randomized-early-phase-trial
#13
Becky Kinkead, Pamela J Schettler, Erika R Larson, Dedric Carroll, Margaret Sharenko, James Nettles, Sherry A Edwards, Andrew H Miller, Mylin A Torres, Boadie W Dunlop, Jeffrey J Rakofsky, Mark Hyman Rapaport
BACKGROUND: Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, yet treatment options for CRF are limited. In this study, we evaluated the efficacy of weekly Swedish massage therapy (SMT) versus an active control condition (light touch [LT]) and waitlist control (WLC) on persistent CRF in breast cancer survivors. METHODS: This early phase, randomized, single-masked, 6-week investigation of SMT, LT, and WLC enrolled 66 female stage 0-III breast cancer survivors (age range, 32-72 years) who had received surgery plus radiation and/or chemotherapy/chemoprevention with CRF (Brief Fatigue Inventory > 25)...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29042405/sterol-methyltransferase-a-target-for-anti-amoeba-therapy-towards-transition-state-analog-and-suicide-substrate-drug-design
#14
Medhanie E Kidane, Boden H Vanderloop, Wenxu Zhou, Crista D Thomas, Emilio Ramos, Ujjal Singha, Minu Chaudhuri, W David Nes
Ergosterol biosynthesis pathways essential to pathogenic protozoa growth (Haubrich, B. A. et al. 2015. J. Lipid Res. 56: 331-341) and absent from the human host offer new chokepoint targets. Here, we present characterization and cell-based interference of Acanthamoeba spp sterol 24/28methylases (SMT) that catalyze the committed step in C28- and C29-sterol synthesis. Intriguingly, our kinetic analyses suggest 24SMT prefers plant cycloartenol while 28SMT prefers 24(28)methylene lophenol in similar fashion to the substrate preferences of land plant SMT1 and SMT2...
October 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28994703/a-straight-skeleton-based-connectivity-restoration-strategy-in-the-presence-of-obstacles-for-wsns
#15
Xiaoding Wang, Li Xu, Shuming Zhou
Connectivity has significance in both of data collection and aggregation for Wireless Sensor Networks (WSNs). Once the connectivity is lost, relay nodes are deployed to build a Steiner Minimal Tree (SMT) such that the inter-component connection is reestablished. In recent years, there has been a growing interest in connectivity restoration problems. In previous works, the deployment area of a WSN is assumed to be flat without obstacles. However, such an assumption is not realistic. In addition, most of the existing strategies chose the representative of each component, which serves as the starting point of relay node deployment during the connectivity restoration, either in a random way or in the shortest-distance based manner...
October 10, 2017: Sensors
https://www.readbyqxmd.com/read/28964258/measuring-ex-vivo-drug-susceptibility-in-plasmodium-vivax-isolates-from-cambodia
#16
Suwanna Chaorattanakawee, Chanthap Lon, Soklyda Chann, Kheang Heng Thay, Nareth Kong, Yom You, Siratchana Sundrakes, Chatchadaporn Thamnurak, Sorayut Chattrakarn, Chantida Praditpol, Kritsanai Yingyuen, Mariusz Wojnarski, Rekol Huy, Michele D Spring, Douglas S Walsh, Jaymin C Patel, Jessica Lin, Jonathan J Juliano, Charlotte A Lanteri, David L Saunders
BACKGROUND: While intensive Plasmodium falciparum multidrug resistance surveillance continues in Cambodia, relatively little is known about Plasmodium vivax drug resistance in Cambodia or elsewhere. To investigate P. vivax anti-malarial susceptibility in Cambodia, 76 fresh P. vivax isolates collected from Oddar Meanchey (northern Cambodia) in 2013-2015 were assessed for ex vivo drug susceptibility using the microscopy-based schizont maturation test (SMT) and a Plasmodium pan-species lactate dehydrogenase (pLDH) ELISA...
September 30, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28959682/an-emergence-framework-of-carcinogenesis
#17
Elizabeth A W Sigston, Bryan R G Williams
Experimental paradigms provide the framework for the understanding of cancer, and drive research and treatment, but are rarely considered by clinicians. The somatic mutation theory (SMT), in which cancer is considered a genetic disease, has been the predominant traditional model of cancer for over 50 years. More recently, alternative theories have been proposed, such as tissue organization field theory (TOFT), evolutionary models, and inflammatory models. Key concepts within the various models have led to them being difficult to reconcile...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28930438/supported-planar-mammalian-membranes-as-models-of-in-vivo-cell-surface-architectures
#18
Han-Yuan Liu, Hannah Grant, Hung-Lun Hsu, Raya Sorkin, Filip Bošković, Gijs Wuite, Susan Daniel
Emerging technologies use cell plasma membrane vesicles or "blebs" as an intermediate to form molecularly complete, planar cell surface mimetics that are compatible with a variety of characterization tools and microscopy methods. This approach enables direct incorporation of membrane proteins into supported lipid bilayers without using detergents and reconstitution and preserves native lipids and membrane species. Such a system can be advantageous as in vitro models of in vivo cell surfaces for study of the roles of membrane proteins as drug targets in drug delivery, host-pathogen interactions, tissue engineering, and many other bioanalytical and sensing applications...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28924697/chiropractic-spinal-manipulation-and-the-risk-for-acute-lumbar-disc-herniation-a-belief-elicitation-study
#19
Cesar A Hincapié, J David Cassidy, Pierre Côté, Y Raja Rampersaud, Alejandro R Jadad, George A Tomlinson
PURPOSE: Chiropractic spinal manipulation treatment (SMT) is common for back pain and has been reported to increase the risk for lumbar disc herniation (LDH), but there is no high quality evidence about this. In the absence of good evidence, clinicians can have knowledge and beliefs about the risk. Our purpose was to determine clinicians' beliefs regarding the risk for acute LDH associated with chiropractic SMT. METHODS: Using a belief elicitation design, 47 clinicians (16 chiropractors, 15 family physicians and 16 spine surgeons) that treat patients with back pain from primary and tertiary care practices were interviewed...
September 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28924554/molecular-cloning-and-functional-identification-of-sterol-c24-methyltransferase-gene-from-tripterygium-wilfordii
#20
Hongyu Guan, Yujun Zhao, Ping Su, Yuru Tong, Yujia Liu, Tianyuan Hu, Yifeng Zhang, Xianan Zhang, Jia Li, Xiaoyi Wu, Luqi Huang, Wei Gao
Sterol C24-methyltransferase (SMT) plays multiple important roles in plant growth and development. SMT1, which belongs to the family of transferases and transforms cycloartenol into 24-methylene cycloartenol, is involved in the biosynthesis of 24-methyl sterols. Here, we report the cloning and characterization of a cDNA encoding a sterol C24-methyltransferase from Tripterygium wilfordii (TwSMT1). TwSMT1 (GenBank access number KU885950) is a 1530 bp cDNA with a 1041 bp open reading frame predicted to encode a 346-amino acid, 38...
September 2017: Acta Pharmaceutica Sinica. B
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