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https://www.readbyqxmd.com/read/29786460/counterexample-driven-genetic-programming-heuristic-program-synthesis-from-formal-specifications
#1
Iwo Błądek, Krzysztof Krawiec, Jerry Swan
Conventional genetic programming (GP) can only guarantee that synthesized programs pass tests given by the provided input-output examples. The alternative to such test-based approach is synthesizing programs by formal specification, typically realized with exact, non-heuristic algorithms. In this paper, we build on our earlier study on Counterexample-Based Genetic Programming (CDGP), an evolutionary heuristic that synthesizes programs from formal specifications. The candidate programs in CDGP undergo formal verification with a Satisfiability Modulo Theory (SMT) solver, which results in counterexamples that are subsequently turned into tests and used to calculate fitness...
May 22, 2018: Evolutionary Computation
https://www.readbyqxmd.com/read/29775985/sensorimotor-exercises-and-enhanced-trunk-function-a-randomized-controlled-trial
#2
Steffen Mueller, Tilman Engel, Juliane Mueller, Josefine Stoll, Heiner Baur, Frank Mayer
The aim of this study was to investigate the effect of a 6-week sensorimotor or resistance training on maximum trunk strength and response to sudden, high-intensity loading in athletes.Forty-three healthy, well-trained participants were randomized into sensorimotor (SMT; n=11), resistance training (RT; n=16) and control groups (CG; n=16). Treatment groups received either sensorimotor training (SMT) or resistance training (RT) for 6 weeks, 3 times a week. At baseline and after 6 weeks of intervention, participants' maximum isokinetic strength in trunk rotation and extension was tested (concentric/eccentric 30°/s)...
May 18, 2018: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29775570/rapid-non-classical-effects-of-steroids-on-the-membrane-receptor-dynamics-and-downstream-signaling-in-neurons
#3
REVIEW
Klaudia Barabás, Soma Godó, Ferenc Lengyel, Dávid Ernszt, József Pál, István M Ábrahám
Although rapid effects of steroid hormones on membrane receptors and intracellular signaling molecules have been extensively studied in neurons, we are only beginning to understand the molecular mechanisms behind these non-classical steroid actions. Single molecule tracking (SMT) studies on live cells demonstrated that surface trafficking of membrane receptors determines their ligand binding properties and downstream signaling events. Recent findings suggest that one of the underlying mechanisms of non-classical steroid actions is the alteration of receptor movements on the membrane surface...
May 15, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29774595/long-term-schneiderian-membrane-thickness-changes-following-zygomatic-implant-placement-a-retrospective-radiographic-analysis-using-cone-beam-computed-tomography
#4
Kai Zhao, Meifei Lian, Shengchi Fan, Wei Huang, Feng Wang, Yiqun Wu
OBJECTIVES: The purpose of this retrospective study was to evaluate the long-term changes in the thickness of Schneiderian membranes after zygomatic implant placement using cone beam computed tomography (CBCT). MATERIAL AND METHODS: Twenty-five consecutive patients were included in this study. All the patients underwent bilateral zygomatic implant placement. Schneiderian membrane thickness (SMT) in 49 maxillary sinuses (one sinus was not included because of early loss of the zygomatic implants) was measured using CBCT before and at least 1 year after zygomatic implant placement...
May 17, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29727380/human-mesenchymal-stem-cells-for-hepatitis-b-virus-related-acute-on-chronic-liver-failure-a-systematic-review-with-meta-analysis
#5
Bin Chen, Yong-Hong Wang, Jin-Qin Qian, Dong-Bo Wu, En-Qiang Chen, Hong Tang
BACKGROUND AND AIM: Acute-on-chronic liver failure (ACLF) is a condition with high mortality. New strategies are urgently required. The present review aims to provide a comprehensive understanding of the efficacy and safety of mesenchymal stem cells (MSC) treatment in patients with ACLF associated with hepatitis B virus infection. MATERIALS AND METHODS: The MEDLINE, Embase, and Cochrane Library databases were searched for the relevant publications. If appropriate, a meta-analysis was carried out for the following outcomes: survival rate, model for end-stage liver disease score, and liver function...
May 3, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29719284/characterization-of-helicobacter-pylori-na%C3%A3-ve-early-gastric-cancers
#6
Akihiro Yamada, Mitsuru Kaise, Naoko Inoshita, Takahito Toba, Kosuke Nomura, Yasutaka Kuribayashi, Satoshi Yamashita, Tsukasa Furuhata, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Osamu Ogawa, Toshiro Iizuka, Shu Hoteya
AIM: Helicobacter pylori-naïve gastric cancers(GCs) have not been well documented. We aimed to characterize early H. pylori-naïve GCs. SUBJECTS AND METHODS: Of 666 patients with GC resected by endoscopic submucosal dissection, H. pylori-naïve patients were extracted according to the definition: no H. pylori eradication history, negative for serum H. pylori-antibody and current H. pylori-infection tests, and no gastric atrophy by pepsinogen (PG) test, endoscopy, and histology...
May 2, 2018: Digestion
https://www.readbyqxmd.com/read/29704228/a-prospective-randomized-controlled-trial-of-the-metabolic-effects-of-sleeve-gastrectomy-with-transit-bipartition
#7
Fernanda R Azevedo, Sergio Santoro, Maria L Correa-Giannella, Marcos T Toyoshima, Daniel Giannella-Neto, Daniela Calderaro, Danielle M Gualandro, Pai C Yu, Bruno Caramelli
PURPOSE: To compare the effects of the sleeve gastrectomy with transit bipartition (SG + TB) procedure with standard medical therapy (SMT) in mildly obese patients with type II diabetes (T2D). METHODS: This is a prospective, randomized, controlled trial. Twenty male adults, ≤ 65 years old, with T2D, body mass index (BMI) > 28 kg/m2 and < 35 kg/m2 , and HbA1c level > 8% were randomized to SG + TB or to SMT. Outcomes were the remission in the metabolic and cardiovascular risk variables up to 24 months...
April 27, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29697401/implementation-of-drug-addicts-right-to-health-protection-separate-aspects
#8
O Shevchuk, O Rzhevska, O Korop, L Pyliuha
The purpose of the research is to analyze specific problems of the realization of the right to protect the health of people who take narcotic drugs or psychotropic substances. To achieve this goal, statistics have been analyzed on the number of people using narcotic drugs or psychotropic substances (including drug-addicted children) placed on medical records and the number of their applications for medical care. It has been found out that people in this category often face a denial of medical care that causes extremely strong physical and mental suffering...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29689531/genomic-and-transcriptomic-alterations-in-leishmania-donovani-lines-experimentally-resistant-to-antileishmanial-drugs
#9
Alberto Rastrojo, Raquel García-Hernández, Paola Vargas, Esther Camacho, Laura Corvo, Hideo Imamura, Jean-Claude Dujardin, Santiago Castanys, Begoña Aguado, Francisco Gamarro, Jose M Requena
Leishmaniasis is a serious medical issue in many countries around the World, but it remains largely neglected in terms of research investment for developing new control and treatment measures. No vaccines exist for human use, and the chemotherapeutic agents currently used are scanty. Furthermore, for some drugs, resistance and treatment failure are increasing to alarming levels. The aim of this work was to identify genomic and trancriptomic alterations associated with experimental resistance against the common drugs used against VL: trivalent antimony (SbIII , S line), amphotericin B (AmB, A line), miltefosine (MIL, M line) and paromomycin (PMM, P line)...
April 13, 2018: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29687809/the-facile-synthesis-of-a-single-atom-dispersed-silver-modified-ultrathin-g-c-3-n-4-hybrid-for-the-enhanced-visible-light-photocatalytic-degradation-of-sulfamethazine-with-peroxymonosulfate
#10
Fengliang Wang, Yingfei Wang, Yanyan Li, Xuhui Cui, Qianxin Zhang, Zhijie Xie, Haijin Liu, Yiping Feng, Wenying Lv, Guoguang Liu
Enabling the optimal usage of solar energy is considered to be one of the most pressing challenges in the photocatalytic remediation of water resident contaminants. Herein, a single-atom dispersed Ag loaded ultrathin g-C3N4 hybrid (AgTCM/UCN) was prepared through a facile co-polymerization of dicyandiamide with silver tricyanomethanide (AgTCM) and NH4Cl, and used as a visible light driven photocatalyst for the degradation of sulfamethazine (SMT) in the presence of peroxymonosulfate (PMS). Under UV light, visible light and simulated sunlight irradiation, the AgTCM/UCN/PMS process showed higher efficiency for SMT degradation than AgTCM/UCN, UCN/PMS, and g-C3N4/PMS systems...
April 24, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29672996/aqueous-chlorination-of-sulfamethazine-and-sulfamethoxypyridazine-kinetics-and-transformation-products-identification
#11
Rania Nassar, Ahmad Rifai, Aurélien Trivella, Patrick Mazellier, Samia Mokh, Mohamad Al-Iskandarani
Sulfonamides (SNs) are synthetic antimicrobial agents. These substances are continually introduced into the environment and they may spread and maintain bacterial resistance in the different compartments. The chlorination of two sulfonamides, namely sulfamethazine (SMT) and sulfamethoxypyridazine (SMP), was investigated in order to study their reactivity with chlorine at typical concentrations for water treatment conditions. Experiments conducted in purified water show an acceleration of SMT and SMP degradation of a factor 1...
April 19, 2018: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/29658656/comparison-between-endoscopic-and-laparoscopic-removal-of-gastric-submucosal-tumor
#12
REVIEW
Nobutsugu Abe, Hirohisa Takeuchi, Atsuko Ohki, Yoshikazu Hashimoto, Toshiyuki Mori, Masanori Sugiyama
BACKGROUND AND AIM: A retrospective study was conducted to compare two resection methods, namely, endoscopic resection (ER) procedures (endoscopic submucosal dissection [ESD], endoscopic muscularis dissection [EMD], and endoscopic full-thickness resection [EFTR]) and laparoscopic resections (LR) (laparoscopic endoscopic cooperative surgery [LECS] and laparoscopic wedge resection). METHODS: Seventy-three patients who underwent ER (N = 33: ESD, N = 4; EMD, N = 15; EFTR, N = 14) or LR (N = 39: LECS, N = 16; wedge resection, N = 23) for gastric submucosal tumor (G-SMT) smaller than 50 mm were included in this study...
April 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29621650/what-matters-more-common-or-specific-factors-in-cognitive-behavioral-therapy-for-ocd-therapeutic-alliance-and-expectations-as-predictors-of-treatment-outcome
#13
Asher Y Strauss, Jonathan D Huppert, H Blair Simpson, Edna B Foa
CBT for obsessive-compulsive disorder (OCD) is a strong challenge to the contention that common factors explain most of the variance in outcomes in all therapies and all disorders, given that the treatment is focused and placebo response is low. In this study, the relative contributions of expectancy and therapeutic alliance as predictors of outcome in the treatment of OCD are examined and compared to the contribution of specific treatment effects. One hundred and eight patients with OCD were randomly assigned to two forms of CBT: exposure and response prevention (EX/RP) or stress management training (SMT)...
March 27, 2018: Behaviour Research and Therapy
https://www.readbyqxmd.com/read/29617120/metal-organic-framework-with-coordinatively-unsaturated-sites-as-efficient-fenton-like-catalyst-for-enhanced-degradation-of-sulfamethazine
#14
Juntao Tang, Jianlong Wang
In this paper, a novel Fenton-like catalyst, metal organic framework MIL-100(Fe) with FeII/FeIII mixed-valence coordinatively unsaturated iron center (CUS-MIL-100(Fe)), was synthesized, characterized and used for the degradation of sulfamethazine (SMT). The catalytic performance of CUS-MIL-100(Fe) was investigated on the basis of various parameters, including initial pH, H2O2 concentration, catalyst dosage and initial SMT concentration. The results showed that CUS-MIL-100(Fe) could effectively degrade SMT, with almost 100% removal efficiency within 180 min (52...
April 4, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29610485/super-long-single-molecule-tracking-reveals-dynamic-anchorage-induced-integrin-function
#15
Taka A Tsunoyama, Yusuke Watanabe, Junri Goto, Kazuma Naito, Rinshi S Kasai, Kenichi G N Suzuki, Takahiro K Fujiwara, Akihiro Kusumi
Single-fluorescent-molecule imaging tracking (SMT) is becoming an important tool to study living cells. However, photobleaching and photoblinking (hereafter referred to as photobleaching/photoblinking) of the probe molecules strongly hamper SMT studies of living cells, making it difficult to observe in vivo molecular events and to evaluate their lifetimes (e.g., off rates). The methods used to suppress photobleaching/photoblinking in vitro are difficult to apply to living cells because of their toxicities. Here using 13 organic fluorophores we found that, by combining low concentrations of dissolved oxygen with a reducing-plus-oxidizing system, photobleaching/photoblinking could be strongly suppressed with only minor effects on cells, which enabled SMT for as long as 12,000 frames (~7 min at video rate, as compared to the general 10-s-order durations) with ~22-nm single-molecule localization precisions...
April 2, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29606335/spinal-manipulative-therapy-and-other-conservative-treatments-for-low-back-pain-a-guideline-from-the-canadian-chiropractic-guideline-initiative
#16
André E Bussières, Gregory Stewart, Fadi Al-Zoubi, Philip Decina, Martin Descarreaux, Danielle Haskett, Cesar Hincapié, Isabelle Pagé, Steven Passmore, John Srbely, Maja Stupar, Joel Weisberg, Joseph Ornelas
OBJECTIVE: The objective of this study was to develop a clinical practice guideline on the management of acute and chronic low back pain (LBP) in adults. The aim was to develop a guideline to provide best practice recommendations on the initial assessment and monitoring of people with low back pain and address the use of spinal manipulation therapy (SMT) compared with other commonly used conservative treatments. METHODS: The topic areas were chosen based on an Agency for Healthcare Research and Quality comparative effectiveness review, specific to spinal manipulation as a nonpharmacological intervention...
March 29, 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29605901/right-ventricular-septomarginal-trabeculation-hypertrophy-is-associated-with-disease-severity-in-patients-with-pulmonary-arterial-hypertension
#17
Yang Dong, Jiayu Sun, Dan Yang, Juan He, Wei Cheng, Ke Wan, Hong Liu, Andreas Greiser, Xiaoyue Zhou, Yuchi Han, Yucheng Chen
To characterize the morphological change in the right ventricle (RV) of patients with pulmonary artery hypertension (PAH) and further explore the correlation between septomarginal trabeculation (SMT) and right ventricular (RV) function, myocardial fibrosis, and exercise capacity in patients with PAH. Sixty untreated PAH patients were prospectively included from May 2016 to April 2017. All patients underwent comprehensive clinical evaluation and cardiac magnetic resonance (CMR). The area and diameter of the basal segment of SMT, and the mass of SMT were measured on cine SSFP images...
March 31, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29604418/biodegradation-of-typical-pharmaceutical-compounds-by-a-novel-strain-acinetobacter-sp
#18
Shizong Wang, Yuming Hu, Jianlong Wang
A novel sulfamethoxazole (SMX)-degrading strain, Acinetobacter sp., was used to degrade other pharmaceutical compounds, including sulfadiazine (SD), sulfamethazine (SMT), trimethoprim (THM), triclosan (TCS), diclofenac (DFC) and carbamazepine (CBZ). The experimental results showed that Acinetobacter sp. can completely degrade SMX, SD and SMT, but with different mineralization efficiency. Acinetobacter sp. can mineralize 98.8% of SMX, while only 17.5% and 20.5% for SD and SMT, respectively. The intermediate products of SMX, SD and SMT degradation were tentatively identified...
March 28, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29596158/spinal-manipulation-and-exercise-for-low-back-pain-in-adolescents-a-randomized-trial
#19
Roni Evans, Mitchell Haas, Craig Schulz, Brent Leininger, Linda Hanson, Gert Bronfort
Low back pain (LBP) is common in adolescence but there is a paucity of high quality research to inform care. We conducted a multicenter randomized trial comparing 12 weeks of spinal manipulative therapy (SMT) combined with exercise therapy (ET) to ET alone.Participants were 185 adolescents aged 12-18 years with chronic LBP.The primary outcome was LBP severity at 12, 26, and 52 weeks. Secondary outcomes included disability, quality of life, medication use, patient and caregiver-rated improvement and satisfaction...
March 27, 2018: Pain
https://www.readbyqxmd.com/read/29558035/the-structure-of-the-vascular-system-of-the-septomarginal-trabecula-in-the-heart-of-an-adult
#20
Miłosz Zajączkowski, Adam Kosiński, Marek Grzybiak, Rafał Kamiński, Agata Kaczyńska, Stanisław Zajączkowski, Ewa Nowicka
BACKGROUND: In cardiology, the paths of the arteries penetrating the septomarginal trabecula (SMT) are especially important. They provide blood supply to the apparatus of the right atrioventricular orifice and often form anastomoses with the system of the right coronary artery. Despite this, only a few publications discuss the morphological aspect of the septomarginal trabecula, and available histological analyses seldom deal with its blood supply. OBJECTIVES: The aim of this study was to analyze the vessel structure of the septomarginal trabecula in terms of the variability of the area of the cross-section of the lumen and the muscular layer of the artery...
March 20, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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