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https://www.readbyqxmd.com/read/28224386/%C3%AE-bisabolol-inhibits-aspergillus-fumigatus-af239-growth-via-affecting-microsomal-%C3%A2-24-sterol-methyltransferase-as-a-crucial-enzyme-in-ergosterol-biosynthesis-pathway
#1
Zahra Jahanshiri, Masoomeh Shams-Ghahfarokhi, Farnoush Asghari-Paskiabi, Reza Saghiri, Mehdi Razzaghi-Abyaneh
Finding new compounds with antifungal properties is an important task due to the side effects of common antifungal drugs and emerging antifungal resistance in fungal strains. ∆(24)-sterol methyltransferase (24-SMT) is a crucial enzyme that plays important roles in fungal ergosterol biosynthesis pathway and is not found in humans. In the present study, the effects of α-bisabolol on Aspergillus fumigatus Af239 growth and ergosterol synthesis on the base of 24-SMT enzyme activity were studied; in addition, the expression of erg6, the gene encoded 24-SMT, was considered...
March 2017: World Journal of Microbiology & Biotechnology
https://www.readbyqxmd.com/read/28220958/contrast-enhanced-harmonic-endoscopic-ultrasonography-for-differential-diagnosis-of-submucosal-tumors-of-the-upper-gastrointestinal-tract
#2
Ken Kamata, Mamoru Takenaka, Masayuki Kitano, Shunsuke Omoto, Takeshi Miyata, Kosuke Minaga, Kentaro Yamao, Hajime Imai, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Takaaki Chikugo, Yasutaka Chiba, Haruhiko Imamoto, Takushi Yasuda, Andrea Lisotti, Pietro Fusaroli, Masatoshi Kudo
BACKGROUND AND AIMS: To evaluate contrast-enhanced harmonic endoscopic ultrasonography (CH-EUS) for the differential diagnosis of submucosal tumors (SMT) of the upper gastrointestinal tract. METHODS: Between June 2008 and May 2015, 157 consecutive patients with submucosal lesions of the upper gastrointestinal tract were evaluated by CH-EUS. This was a single-center retrospective analysis of prospectively collected data in a registry. The data from 73 patients who later underwent surgical resection were analyzed in this study...
February 21, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28209805/effects-of-photophase-illuminance-on-locomotor-activity-urine-production-and-urinary-6-sulfatoxymelatonin-in-nocturnal-and-diurnal-south-african-rodents
#3
Ingrid van der Merwe, Maria K Oosthuizen, Andre Ganswindt, Abraham Haim, Nigel C Bennett
Effects of photophase illuminance (1, 10, 100 and 330 lux of white incandescent lighting) on daily rhythms of locomotor activity, urine production and 6-sulfatoxymelatonin (6-SMT; 10 lux vs. 330 lux) were studied in nocturnal Namaqua rock mice (Micaelamys namaquensis) and diurnal four striped field mice (Rhabdomys pumilio). Micaelamys namaquensis was consistently nocturnal (∼90-94% nocturnal activity), whereas considerable individual variation marked activity profiles in R. pumilio, but with activity mostly pronounced around twilight (∼55-66% diurnal activity)...
February 16, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28199409/effect-of-chinese-patent-medicine-si-mo-tang-oral-liquid-for-functional-dyspepsia-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#4
Yunxia Hu, Yu Bai, Zhiyun Hua, Jie Yang, Huahui Yang, Wenjun Chen, Junwei Xu, Zhiqiang Zhao
BACKGROUND: Si-Mo-Tang oral liquid (SMT) has been widely used to treat functional dyspepsia (FD), but the effectiveness is still controversial. A systematic review and meta-analysis of randomized controlled trials (RCTs) were performed to assess the efficacy and adverse effects of SMT for FD. METHODS: Investigators searched for articles with publication dates to June 21, 2016, from 9 English and Chinese electronic databases. Comparisons were SMT alone or SMT in combination with western medicine as experimental intervention, and western medicine or placebo as the control...
2017: PloS One
https://www.readbyqxmd.com/read/28168751/easily-measurable-noninvasive-and-novel-finding-for-pulmonary-hypertension-hypertrophy-of-the-basal-segment-of-septomarginal-trabeculation-of-right-ventricle
#5
Gultekin Karakus, Ertugrul Zencirci, Aleks Degirmencioglu, Tolga Sinan Güvenc, Hale Unal Aksu, Aydin Yildirim
BACKGROUND: Effect of pulmonary hypertension (PH) on right ventricular (RV) geometry constitutes an ideal target to assess both pulmonary artery pressure (PAP) and its physiological importance. In this study, we evaluated the diagnostic power of the basal segment of septomarginal trabeculation (SMT) in predicting the PH and RV hypertrophy by cardiovascular magnetic resonance (CMR) in patients with idiopathic pulmonary arterial hypertension (IPAH) and Eisenmenger's syndrome (ES). METHODS: Eleven patients with IPAH, seven patients with ES, and 20 healthy controls were enrolled...
February 6, 2017: Echocardiography
https://www.readbyqxmd.com/read/28167971/glucose-metabolic-changes-in-the-brain-and-muscles-of-patients-with-nonspecific-neck-pain-treated-by-spinal-manipulation-therapy-a-18-f-fdg-pet-study
#6
Akie Inami, Takeshi Ogura, Shoichi Watanuki, Md Mehedi Masud, Katsuhiko Shibuya, Masayasu Miyake, Rin Matsuda, Kotaro Hiraoka, Masatoshi Itoh, Arlan W Fuhr, Kazuhiko Yanai, Manabu Tashiro
Objective. The aim of this study was to investigate changes in brain and muscle glucose metabolism that are not yet known, using positron emission tomography with [(18)F]fluorodeoxyglucose ([(18)F]FDG PET). Methods. Twenty-one male volunteers were recruited for the present study. [(18)F]FDG PET scanning was performed twice on each subject: once after the spinal manipulation therapy (SMT) intervention (treatment condition) and once after resting (control condition). We performed the SMT intervention using an adjustment device...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28156158/the-transition-from-day-to-night-activity-is-a-risk-factor-for-the-development-of-cns-oxygen-toxicity-in-the-diurnal-fat-sand-rat-psammomys-obesus
#7
Mirit Eynan, Adi Biram, Michael Mullokandov, Noga Kronfeld-Schor, Rotem Paz-Cohen, Dvir Menajem, Yehuda Arieli
Performance and safety are impaired in employees engaged in shift work. Combat divers who use closed-circuit oxygen diving apparatus undergo part of their training during the night hours. The greatest risk involved in diving with such apparatus is the development of central nervous system oxygen toxicity (CNS-OT). We investigated whether the switch from day-to-night activity may be a risk factor for the development of CNS-OT using a diurnal animal model, the fat sand rat (Psammomys obesus). Animals were kept on a 12:12 light-dark schedule (6 a...
February 3, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28146021/spinal-tissue-loading-created-by-different-methods-of-spinal-manipulative-therapy-smt-application
#8
Martha Funabashi, François Nougarou, Martin Descarreaux, Narasimha Prasad, Gregory N Kawchuk
STUDY DESIGN: Comparative study using robotic replication of SMT vertebral kinematics together with serial dissection. OBJECTIVE: To quantify loads created in cadaveric spinal tissues arising from three different forms of SMT application. SUMMARY OF BACKGROUND DATA: There exist many distinct methods by which to apply spinal manipulative therapy (SMT). It is not known presently if different forms of SMT application have different effects on spinal tissues...
January 31, 2017: Spine
https://www.readbyqxmd.com/read/28133329/-a-case-of-a-laparoscopically-resected-gastrointestinal-stromal-tumor-of-the-stomach
#9
Tomoki Hariu, Yoshihito Nako, Shigeki Yamasaki, Takashi Kitade, Motomi Wakasa, Teruhisa Sonoyama
During treatment for sigmoid colon diverticulitis, a 72-year-old man underwent abdominal computed tomography, which revealed a gastric tumor that was approximately 40mm in diameter. He then underwent a detailed examination after the remission of diverticulitis. The gastric mucosa was found to be unremarkable on gastrointestinal endoscopy. On ultrasonic endoscopy, however, a hypoechoic mass of approximately 40mm in diameter was detected in the fourth layer of the gastric fornix and was believed to be a gastric submucosal tumor(SMT)...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133260/-a-case-of-esophageal-submucosal-tumor-undiagnosed-preoperatively-and-treated-with-thoracoscopic-enucleation
#10
Akihiro Tokuhisa, Shigeru Takeda, Shinsuke Kanekiyo, Mitsuo Nishiyama, Masahiro Kitahara, Michihisa Iida, Kazuhiko Sakamoto, Nobuaki Suzuki, Tomio Ueno, Shigeru Yamamoto, Shigefumi Yoshino, Shoichi Hazama, Hiroaki Nagano
An asymptomatic 35-year-old man visited our hospital because of an esophageal abnormality identified on a medical check-up. Gastrointestinal endoscopic examination revealed a 4 cm diameter submucosal tumor(SMT)in the upper esophagus. endoscopic ultrasound fine-needle aspiration biopsy(EUS-FNAB)was performed. Histopathological examination showed that it was strongly positive for a-SMA and partially positive for c-kit. An esophageal leiomyoma was suspected but esophageal gastrointestinal stromal tumor(GIST)could not be completely ruled out...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133251/-a-giant-appendiceal-mucinous-neoplasm-treated-with-laparoscopic-surgery
#11
Yoshito Nako, Shigeki Yamazaki, Takashi Kitade, Tomoki Hariu, Motomi Wakasa, Masayoshi Nakanishi, Teruhisa Sonoyama
We encountered a case of giant appendiceal mucinous neoplasm that was treated with laparoscopic surgery. The patient was a 77-year-old man with constipation. Lower endoscopy demonstrated a giant SMT-like tumor in the cecum, and abdominal computed tomography revealed a giant appendiceal mucinous neoplasm and nearby lymph nodes swelling. Hematological examination showed an elevated serum CEA level. We performed laparoscopic ileocecal resection for a definite diagnosis and treatment. The postoperative course was uneventful...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28122640/rational-and-design-of-an-individual-participant-data-meta-analysis-of-spinal-manipulative-therapy-for-chronic-low-back-pain-a-protocol
#12
A de Zoete, M R de Boer, M W van Tulder, S M Rubinstein, M Underwood, J A Hayden, J Kalter, R Ostelo
BACKGROUND: Chronic low back pain (LBP) is the leading cause of pain and disability, resulting in a major socioeconomic impact. The Cochrane Review which examined the effect of spinal manipulative therapy (SMT) for chronic LBP concluded that SMT is moderately effective, but was based on conventional meta-analysis of aggregate data. The use of individual participant data (IPD) from trials allows for a more precise estimate of the treatment effect and has the potential to identify moderators and/or mediators...
January 26, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28120869/change-in-microbial-community-in-landfill-refuse-contaminated-with-antibiotics-facilitates-denitrification-more-than-the-increase-in-arg-over-long-term
#13
Dong Wu, Guanzhou Chen, Xiaojun Zhang, Kai Yang, Bing Xie
In this study, the addition of sulfamethazine (SMT) to landfill refuse decreased nitrogen intermediates (e.g. N2O and NO) and dinitrogen (N2) gas fluxes to <0.5 μg-N/kg-refuse·h(-1), while the N2O and N2 flux were at ~1.5 and 5.0 μg-N/kg-refuse·h(-1) respectively in samples to which oxytetracycline (OTC) had been added. The ARG (antibiotic resistance gene) levels in the refuse increased tenfold after long-term exposure to antibiotics, followed by a fourfold increase in the N2 flux, but SMT-amended samples with the largest resistome facilitated the denitrification (the nitrogen accumulated as NO gas at ~6 μg-N/kg-refuse·h(-1)) to a lesser extent than OTC-amended samples...
January 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28103654/rapid-on-site-evaluation-by-endosonographers-during-endoscopic-ultrasonography-guided-fine-needle-aspiration-for-diagnosis-of-gastrointestinal-stromal-tumors
#14
Takashi Tamura, Yasunobu Yamashita, Kazuki Ueda, Yuki Kawaji, Masahiro Itonaga, Shin-Ichi Murata, Kaori Yamamoto, Takeichi Yoshida, Hiroki Maeda, Takao Maekita, Mikitaka Iguchi, Hideyuki Tamai, Masao Ichinose, Jun Kato
Background/Aims: Endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) has been used to diagnose gastrointestinal submucosal tumors (SMTs). Although rapid on-site evaluation (ROSE) has been reported to improve the diagnostic accuracy of EUS-FNA for pancreatic lesions, on-site cytopathologists are not routinely available. Given this background, the usefulness of ROSE by endosonographers themselves for pancreatic tumors has also been reported. However, ROSE by endosonographers for diagnosis of SMT has not been reported...
January 20, 2017: Clinical Endoscopy
https://www.readbyqxmd.com/read/28098965/continuous-tuning-of-phase-transition-temperature-in-vo2-thin-films-on-c-cut-sapphire-substrates-via-strain-variation
#15
Jie Jian, Xuejing Wang, Leigang Li, Meng Fan, Wenrui Zhang, Jijie Huang, Zhimin Qi, Haiyan Wang
Vanadium dioxide (VO2) thin films with controlled thicknesses are deposited on c-cut sapphire substrates with Al-doped ZnO (AZO) buffer layers by pulsed laser deposition. The surface roughness of AZO buffer layers is varied by controlling oxygen pressure during growth. The strain in the VO2 lattice is found to be dependent on the VO2 thickness and the VO2/AZO interface roughness. The semiconductor-to-metal transition (SMT) properties of VO2 thin films are characterized and the transition temperature (Tc) is successfully tuned by the VO2 thickness as well as the VO2/AZO interface roughness...
February 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28092052/real-time-single-molecule-visualization-of-sh2-domain-membrane-recruitment-in-growth-factor-stimulated-cells
#16
Dongmyung Oh
In the last decade, single molecule tracking (SMT) techniques have emerged as a versatile tool for molecular cell biology research. This approach allows researchers to monitor the real-time behavior of individual molecules in living cells with nanometer and millisecond resolution. As a result, it is possible to visualize biological processes as they occur at a molecular level in real time. Here we describe a method for the real-time visualization of SH2 domain membrane recruitment from the cytoplasm to epidermal growth factor (EGF) induced phosphotyrosine sites on the EGF receptor...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28091655/probing-the-magnetic-relaxation-and-magnetic-moment-arrangement-in-a-series-of-dy4-squares
#17
Jianfeng Wu, Shuang-Yan Lin, Si Shen, Xiao-Lei Li, Lang Zhao, Li Zhang, Jinkui Tang
Three μ4-O bridged Dy4 squares, {[Dy4(μ4-O)(HL(1))4(H2O)4]2(NO3)3(OH)}·2H2O·2CH3OH (1), [Dy4(μ4-O)(HL(2))4(SCN)2]·2H2O·4CH3OH (2) and [Dy4(μ4-O)(H2L(3))2(SCN)2]·6H2O (3) were assembled by using a Schiff base ligand and its dimerized and reduced congener, respectively. These complexes share a similar μ4-O bridged Dy4 core, while, both the coordination geometry and metal-ligand interactions are slightly changed upon the modulation of the ligands, resulting in distinct single-molecular magnetic (SMM) and single-molecular toroic (SMT) properties...
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28058023/laparoscopic-and-endoscopic-co-operative-surgery-for-non-ampullary-duodenal-tumors
#18
Daisuke Ichikawa, Shuhei Komatsu, Osamu Dohi, Yuji Naito, Toshiyuki Kosuga, Kazuhiro Kamada, Kazuma Okamoto, Yoshito Itoh, Eigo Otsuji
AIM: To assess the safety and feasibility of laparoscopic and endoscopic co-operative surgery (LECS) for early non-ampullary duodenal tumors. METHODS: Twelve patients with a non-ampullary duodenal tumor underwent LECS at our hospital. One patient had two mucosal lesions in the duodenum. The indication for this procedure was the presence of duodenal tumors with a low risk for lymph node metastasis. In particular, the tumors included small (less than 10 mm) submucosal tumors (SMT) and epithelial mucosal tumors, such as mucosal cancers or large mucosal adenomas with malignant suspicion...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28017603/guideline-for-reporting-interventions-on-spinal-manipulative-therapy-consensus-on-interventions-reporting-criteria-list-for-spinal-manipulative-therapy-circle-smt
#19
Ruud Groeneweg, Sidney M Rubinstein, Rob A B Oostendorp, Raymond W J G Ostelo, Maurits W van Tulder
OBJECTIVE: The aim of the Consensus on Interventions Reporting Criteria List for Spinal Manipulative Therapy (CIRCLe SMT) study was to develop a criteria list for reporting spinal manipulative therapy (SMT). METHODS: A Delphi procedure was conducted from September 2011 to April 2013 and consisted of international experts in the field of SMT. The authors formed a steering committee and invited participants, selected initial items, structured the comments of the participants after each Delphi round, and formulated the feedback...
February 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/27997109/strain-effects-in-epitaxial-vo2-thin-films-on-columnar-buffer-layer-tio2-al2o3-virtual-substrates
#20
Eric Breckenfeld, Heungsoo Kim, Katherine Burgess, Nicholas Charipar, Shu-Fan Cheng, Rhonda Stroud, Alberto Piqué
Epitaxial VO2/TiO2 thin film heterostructures were grown on (100) (m-cut) Al2O3 substrates via pulsed laser deposition. We have demonstrated the ability to reduce the semiconductor-metal transition (SMT) temperature of VO2 to ∼44 °C while retaining a 4 order of magnitude SMT using the TiO2 buffer layer. A combination of electrical transport and X-ray diffraction reciprocal space mapping studies help examine the specific strain states of VO2/TiO2/Al2O3 heterostructures as a function of TiO2 film growth temperatures...
January 18, 2017: ACS Applied Materials & Interfaces
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