Tyler Quinn, Jill M Cholette, Matthew G Pinto, Hilary Schreiber, Maureen A Madden, Erin Bennett, Amanda Kolmar, Alan Poole, Cicero T Silva, Lauren Ehrlich, Oscar M Navarro, E Vincent S Faustino
BACKGROUND: Normalization of antithrombin activity may prevent catheter-associated thrombosis in critically ill children at high risk of bleeding. OBJECTIVES: To characterize the temporal pattern of antithrombin activity, assess its association with catheter-associated thrombosis and clinically relevant bleeding, and evaluate its relationship with thrombin generation in these children. PATIENTS/METHODS: In this prospective cohort study, critically ill children <18 years old at high risk of bleeding with central venous catheter were eligible...
October 3, 2023: Journal of Thrombosis and Haemostasis: JTH