keyword
https://read.qxmd.com/read/38417917/tgf%C3%AE-specific-t-cells-induced-by-a-tgf%C3%AE-derived-immune-modulatory-vaccine-both-directly-and-indirectly-modulate-the-phenotype-of-tumor-associated-macrophages-and-fibroblasts
#21
JOURNAL ARTICLE
Maria Perez-Penco, Lucia Lara de la Torre, Inés Lecoq, Evelina Martinenaite, Mads Hald Andersen
The tumor microenvironment (TME) of pancreatic cancer is highly immunosuppressive. We recently developed a transforming growth factor (TGF)β-based immune modulatory vaccine that controlled tumor growth in a murine model of pancreatic cancer by targeting immunosuppression and desmoplasia in the TME. We found that treatment with the TGFβ vaccine not only reduced the percentage of M2-like tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) in the tumor but polarized CAFs away from the myofibroblast-like phenotype...
February 27, 2024: Journal for Immunotherapy of Cancer
https://read.qxmd.com/read/38414615/association-between-visceral-fat-area-and-diabetic-retinopathy-among-people-with-type-2-diabetes-mellitus-a-cross-sectional-study-in-ningbo-zhejiang-province-china
#22
JOURNAL ARTICLE
Shanshan Hua, Dongwei Yao, Siteng Wu, Miao Chen, Li Li, Bo Li
AIM: The objective of this study is to investigate the relationship between visceral fat area (VFA) and diabetic retinopathy (DR) in the context of type 2 diabetes mellitus (T2DM) within Ningbo, China. METHODS: The data of a total of 3,707 subjects with T2DM treated at The First Affiliated Hospital of Ningbo University were enrolled. The existence and severity of diabetic retinopathy were assessed by employing the 45° two-field stereoscopic digital photography...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38410271/graphene-based-functional-electrochemical-sensors-for-the-detection-of-chlorpyrifos-in-water-and-food-samples-a-review
#23
REVIEW
Pitchurajan Krishna Perumal, Chiu-Wen Chen, Balendu Shekher Giri, Reeta Rani Singhania, Anil Kumar Patel, Cheng-Di Dong
Prolonged and excessive use of chlorpyrifos (CPS) has caused severe pollution, particularly in crops, vegetables, fruits, and water sources. As a result, CPS is detected in various food and water samples using conventional methods. However, its applications are limited due to size, portability, cost, etc. In this regard, electrochemical sensors are preferred for CPS detection due to their high sensitivity, reliability, rapid, on-site detection, and user-friendly. Notably, graphene-based electrochemical sensors have gained more attention due to their unique physiochemical and electrochemical properties...
April 2024: Journal of Food Science and Technology
https://read.qxmd.com/read/38408001/a-bioimpedance-spectroscopy-interface-for-eim-based-on-if-sampling-and-pseudo-2-path-sc-bandpass-%C3%AE-%C3%AE-adc
#24
JOURNAL ARTICLE
Alejandro D Fernandez Schrunder, Yu-Kai Huang, Saul Rodriguez, Ana Rusu
This paper presents a low-noise bioimpedance (bio-Z) spectroscopy interface for electrical impedance myography (EIM) over the 1 kHz to 2 MHz frequency range. The proposed interface employs a sinusoidal signal generator based on direct-digital-synthesis (DDS) to improve the accuracy of the bio-Z reading, and a quadrature low-intermediate frequency (IF) readout to achieve a good noise-to-power efficiency and the required data throughput to detect muscle contractions. The readout is able to measure baseline and time-varying bio-Z by employing robust and power-efficient low-gain IAs and sixth-order single-bit bandpass (BP) ΔΣ ADCs...
February 26, 2024: IEEE Transactions on Biomedical Circuits and Systems
https://read.qxmd.com/read/38401280/sensing-of-gene-expression-in-live-cells-using-electrical-impedance-spectroscopy-and-dna-functionalized-gold-nanoparticles
#25
JOURNAL ARTICLE
Kian Kadan-Jamal, Aakash Jog, Marios Sophocleous, Tali Dotan, Polina Frumin, Tamar Kuperberg Goshen, Silvia Schuster, Adi Avni, Yosi Shacham-Diamand
A novel electrical impedance spectroscopy-based method for non-destructive sensing of gene expression in living cells is presented. The approach used takes advantage of the robustness and responsiveness of electrical impedance spectroscopy and the highly specific and selective nature of DNA hybridization. The technique uses electrical impedance spectroscopy and gold nanoparticles functionalized with single-stranded DNA complementary to an mRNA of interest to provide reliable, real-time, and quantifiable data on gene expression in live cells...
January 16, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38400474/wearable-technology-for-monitoring-electrocardiograms-ecgs-in-adults-a-scoping-review
#26
REVIEW
Ekta Singh Dahiya, Anubha Manju Kalra, Andrew Lowe, Gautam Anand
In the rapidly evolving landscape of continuous electrocardiogram (ECG) monitoring systems, there is a heightened demand for non-invasive sensors capable of measuring ECGs and detecting heart rate variability (HRV) in diverse populations, ranging from cardiovascular patients to sports enthusiasts. Challenges like device accuracy, patient privacy, signal noise, and long-term safety impede the use of wearable devices in clinical practice. This scoping review aims to assess the performance and safety of novel multi-channel, sensor-based biopotential wearable devices in adults...
February 18, 2024: Sensors
https://read.qxmd.com/read/38400007/saikosaponin-b2-punicalin-and-punicalagin-in-vitro-block-cellular-entry-of-feline-herpesvirus-1
#27
JOURNAL ARTICLE
Bin Liu, Xiao-Qian Jiao, Xu-Feng Dong, Pei Guo, Shu-Bai Wang, Zhi-Hua Qin
In the realm of clinical practice, nucleoside analogs are the prevailing antiviral drugs employed to combat feline herpesvirus-1 (FHV-1) infections. However, these drugs, initially formulated for herpes simplex virus (HSV) infections, operate through a singular mechanism and are susceptible to the emergence of drug resistance. These challenges underscore the imperative to innovate and develop alternative antiviral medications featuring unique mechanisms of action, such as viral entry inhibitors. This research endeavors to address this pressing need...
February 1, 2024: Viruses
https://read.qxmd.com/read/38396265/surface-bio-engineered-polymeric-nanoparticles
#28
REVIEW
Laura Libnan Haidar, Marcela Bilek, Behnam Akhavan
Surface bio-engineering of polymeric nanoparticles (PNPs) has emerged as a cornerstone in contemporary biomedical research, presenting a transformative avenue that can revolutionize diagnostics, therapies, and drug delivery systems. The approach involves integrating bioactive elements on the surfaces of PNPs, aiming to provide them with functionalities to enable precise, targeted, and favorable interactions with biological components within cellular environments. However, the full potential of surface bio-engineered PNPs in biomedicine is hampered by obstacles, including precise control over surface modifications, stability in biological environments, and lasting targeted interactions with cells or tissues...
February 23, 2024: Small
https://read.qxmd.com/read/38394704/novel-high-dense-microelectrode-array-based-multimodal-bioelectronic-monitoring-system-for-cardiac-arrhythmia-re-entry-analysis
#29
JOURNAL ARTICLE
Sabine Schmidt, Wener Li, Mario Schubert, Björn Binnewerg, Christoph Prönnecke, Franziska D Zitzmann, Martin Bulst, Sebastian Wegner, Matthias Meier, Kaomei Guan, Heinz-Georg Jahnke
In recent decades, significant progress has been made in the treatment of heart diseases, particularly in the field of personalized medicine. Despite the development of genetic tests, phenotyping and risk stratification are performed based on clinical findings and invasive in vivo techniques, such as stimulation conduction mapping techniques and programmed ventricular pacing. Consequently, label-free non-invasive in vitro functional analysis systems are urgently needed for more accurate and effective in vitro risk stratification, model-based therapy planning, and clinical safety profile evaluation of drugs...
February 14, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38392636/leveraging-machine-learning-for-personalized-wearable-biomedical-devices-a-review
#30
REVIEW
Ali Olyanasab, Mohsen Annabestani
This review investigates the convergence of artificial intelligence (AI) and personalized health monitoring through wearable devices, classifying them into three distinct categories: bio-electrical, bio-impedance and electro-chemical, and electro-mechanical. Wearable devices have emerged as promising tools for personalized health monitoring, utilizing machine learning to distill meaningful insights from the expansive datasets they capture. Within the bio-electrical category, these devices employ biosignal data, such as electrocardiograms (ECGs), electromyograms (EMGs), electroencephalograms (EEGs), etc...
February 13, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38391996/impedimetric-detection-of-cancer-markers-based-on-nanofiber-copolymers
#31
JOURNAL ARTICLE
Noha Elnagar, Nada Elgiddawy, Waleed M A El Rouby, Ahmed A Farghali, Hafsa Korri-Youssoufi
The sensitive determination of folate receptors (FRs) in the early stages of cancer is of great significance for controlling the progression of cancerous cells. Many folic acid (FA)-based electrochemical biosensors have been utilized to detect FRs with promising performances, but most were complicated, non-reproducible, non-biocompatible, and time and cost consuming. Here, we developed an environmentally friendly and sensitive biosensor for FR detection. We proposed an electrochemical impedimetric biosensor formed by nanofibers (NFs) of bio-copolymers prepared by electrospinning...
January 31, 2024: Biosensors
https://read.qxmd.com/read/38370455/sensitive-electrochemical-gold-nanoparticle-based-immunosensor-for-norovirus-detection-in-food-samples
#32
JOURNAL ARTICLE
Paulina Janicka, Sylwia Baluta, Juliusz Winiarski, Kinga Halicka-Stępień, Aleksandra Pogorzelska, Joanna Cabaj, Katarzyna Pala, Barbara Bażanów
Norovirus (NoV) infection is one of the most common non-bacterial causes of gastroenteritis among the population worldwide. From the point of view of medical diagnostics, it is important to develop a system that would sensitively and selectively detect norovirus from a patient's sample in order to control and limit its spread. In this paper, we present a stable and sensitive NoV (mouse model) detection matrix in infected food samples. The bio-platform was made of a modified gold electrode with a self-assembled l-cysteine monolayer, covered with gold nanoparticles, a linker and an antibody specific to the VP1 surface protein of the virus...
February 14, 2024: RSC Advances
https://read.qxmd.com/read/38362813/engineered-bio-based-hydrogels-for-cancer-immunotherapy
#33
REVIEW
Yuxuan Peng, Shuang Liang, Qian-Fang Meng, Dan Liu, Kongshuo Ma, Mengli Zhou, Kaiqing Yun, Lang Rao, Zhaohui Wang
Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy and severe immune-related side effects are frequently encountered, especially in solid tumors. Hydrogels, a class of versatile materials featuring well-hydrated structures widely used in biomedicine, offer a promising platform for encapsulating and releasing small molecule drugs, biomacromolecules, and cells in a controlled manner...
February 16, 2024: Advanced Materials
https://read.qxmd.com/read/38356406/rhizobacteria-bacillus-spp-mitigate-osmotic-stress-and-improve-seed-germination-in-mustard-by-regulating-osmolyte-and-plant-hormone-signaling
#34
JOURNAL ARTICLE
Nagarajan Nivetha, Arambam Devi Asha, Gopinathan Kumar Krishna, Viswanathan Chinnusamy, Sangeeta Paul
Drought, a widespread abiotic stressor, exerts a profound impact on agriculture, impeding germination and plant growth, and reducing crop yields. In the present investigation, the osmotolerant rhizobacteria Bacillus casamancensis strain MKS-6 and Bacillus sp. strain MRD-17 were assessed for their effects on molecular processes involved in mustard germination under osmotic stress conditions. Enhancement in germination was evidenced by improved germination percentages, plumule and radicle lengths, and seedling vigor upon rhizobacterial inoculation under no stress and osmotic stress conditions...
2024: Physiologia Plantarum
https://read.qxmd.com/read/38350124/soft-electrodes-for-simultaneous-bio-potential-and-bio-impedance-study-of-the-face
#35
JOURNAL ARTICLE
Bara Levit, Paul F Funk, Yael Hanein
The human body's vascular system is a finely regulated network: Blood vessels can change in shape (i.e. constrict, or dilate), their elastic response may shift and they may undergo temporary and partial blockages due to pressure applied by skeletal muscles in their immediate vicinity. Simultaneous measurement
of muscle activation and the corresponding changes in vessel diameter, in particular in regions such as the face, is challenging, and the manner by which muscle activation constricts blood vessels has been experimentally largely overlooked...
February 13, 2024: Biomedical Physics & Engineering Express
https://read.qxmd.com/read/38346008/blood-brain-barrier-penetrating-and-lesion-targeting-nanoplatforms-inspired-by-the-pathophysiological-features-for-synergistic-ischemic-stroke-therapy
#36
JOURNAL ARTICLE
Lu Tang, Yue Yin, Hening Liu, Mengliang Zhu, Yuqi Cao, Jingwen Feng, Cong Fu, Zixuan Li, Weijie Shu, Jifan Gao, Xing-Jie Liang, Wei Wang
Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public health. Due to its complicated pathophysiological features, current treatment options after ischemic stroke attack remains unsatisfactory. Insufficient drug delivery to ischemic lesions impeded by the blood-brain barrier (BBB) largely limits the therapeutic efficacy of most anti-stroke agents. Herein, inspired by the rapid BBB penetrability of 4T1 tumor cells upon their brain metastasis and natural roles of platelet in targeting injured vasculatures, a bio-derived nanojacket was developed by fusing 4T1 tumor cell membrane with platelet membrane, which further clothed on the surface of paeonol and polymetformin-loaded liposome to obtain biomimetic nanoplatforms (PP@PCL) for ischemic stroke treatment...
February 12, 2024: Advanced Materials
https://read.qxmd.com/read/38339574/pathogen-detection-via-impedance-spectroscopy-based-biosensor
#37
JOURNAL ARTICLE
Tharun Reddy Kandukuri, Ioannis Prattis, Pelumi Oluwasanya, Luigi G Occhipinti
This paper presents the development of a miniaturized sensor device for selective detection of pathogens, specifically Influenza A Influenza virus, as an enveloped virus is relatively vulnerable to damaging environmental impacts. In consideration of environmental factors such as humidity and temperature, this particular pathogen proves to be an ideal choice for our study. It falls into the category of pathogens that pose greater challenges due to their susceptibility. An impedance biosensor was integrated into an existing platform and effectively separated and detected high concentrations of airborne pathogens...
January 28, 2024: Sensors
https://read.qxmd.com/read/38339372/pre-operative-malnutrition-in-patients-with-ovarian-cancer-what-are-the-clinical-implications-results-of-a-prospective-study
#38
JOURNAL ARTICLE
Sara Nasser, Esra Bilir, Xezal Derin, Rolf Richter, Jacek P Grabowski, Paulina Ali, Hagen Kulbe, Radoslav Chekerov, Elena Braicu, Jalid Sehouli
BACKGROUND: Malnutrition was associated with worse survival outcomes, impaired quality of life, and deteriorated performance status across various cancer types. We aimed to identify risk factors for malnutrition in patients with epithelial ovarian cancer (EOC) and impact on survival. METHODS: In our prospective observational monocentric study, we included the patients with primary and recurrent EOC, tubal or peritoneal cancer conducted. We assessed serum laboratory parameters, body mass index, nutritional risk index, nutritional risk screening score (NRS-2002), and bio-electrical impedance analysis...
January 31, 2024: Cancers
https://read.qxmd.com/read/38326107/biodegradable-solid-polymer-electrolytes-from-the-discarded-cataractous-eye-protein-isolate
#39
JOURNAL ARTICLE
Prasun Chowdhury, Abhijit Lincon, Shishir Bhowmik, Atul Kumar Ojha, Sreshtha Chaki, Tridib Samanta, Atri Sen, Swagata Dasgupta
The protein extracted from the discarded eye lenses postcataract surgery, referred to as the cataractous eye protein isolate (CEPI), is employed as a polymer matrix for the construction of solid polymer electrolyte species (SPEs). SPEs are expected to be inexpensive, conductive, and mechanically stable in order to be economically and commercially viable. Environmentally, these materials should be biodegradable and nontoxic. Taking these factors into account, we investigated the possibility of using a discarded protein as a polymer matrix for SPEs...
February 7, 2024: ACS Applied Bio Materials
https://read.qxmd.com/read/38320257/nutritional-physiology-and-body-composition-changes-during-a-rapid-ascent-to-high-altitude
#40
JOURNAL ARTICLE
Carmen Santangelo, Vittore Verratti, Simona Mrakic-Sposta, Federica Ciampini, Sofia Bonan, Pamela Pignatelli, Tiziana Pietrangelo, Serena Pilato, Samanta Moffa, Antonella Fontana, Raffaela Piccinelli, Cinzia Le Donne, Lucio Lobefalo, Matteo Beccatelli, Pierluigi Lodi Rizzini, Davide Seletti, Rocco Mecca, Tommaso Beccatelli, Danilo Bondi
Exposure to high altitude might cause the body to adapt with negative energy and fluid balance that compromise body composition and physical performance. In this field study involving 12 healthy adults, sex-balanced, aged 29±4 years with a body mass index 21.6±1.8 kg/m2, we investigated the effects fo a 4-day trekking up to 4556 m a.s.l. on Monte Rosa (Alps, Italy). The food intake was recorded using food diaries and nutrients averages were calculated. The bio-impedance analysis was performed at low and high altitude, and a wearable biosensor (Swemax) was used to track hydro-saline losses in 2 participants...
February 6, 2024: Applied Physiology Nutrition and Metabolism
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