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https://www.readbyqxmd.com/read/27911959/barriers-to-timely-and-safe-blood-transfusion-for-pph-patients-evidence-from-a-qualitative-study-in-dhaka-bangladesh
#1
Sadika Akhter, Iqbal Anwar, Rashida Akter, Feroza Akhter Kumkum, Monjura Khatun Nisha, Fatema Ashraf, Ferdousi Islam, Nazneen Begum, Mahbub Elahi Chowdhury, Anne Austin, Syed Shariful Islam, Aminur Rahman
BACKGROUND AND OBJECTIVES: In Bangladesh, postpartum hemorrhage (PPH) is the leading cause of maternal mortality accounting for 31% of all blood transfusions in the country. Although safe blood transfusion is one of the 8 signal functions of Comprehensive Emergency Obstetric Care (CEmOC) strategy, most of the designated public sector CEmOC facilities do not have on-site blood storage system. Emergent blood is mainly available from external blood banks. As a result, emergent patients are to rely on an unregulated network of brokers for blood which may raise question about blood safety...
2016: PloS One
https://www.readbyqxmd.com/read/27904454/red-blood-cell-transfusion-and-skeletal-muscle-tissue-oxygenation-in-anaemic-haematologic-outpatients
#2
Matej Podbregar, Ana Ursula Gavric, Eva Podbregar, Hugon Mozina, Sebastian Stefanovic
BACKGROUND: Stored red blood cells (RBCs) accumulate biochemical and biophysical changes, known as storage lesion. The aim of this study was to re-challenge current data that anaemia in chronically anaemic haematology patients is not associated with low skeletal muscle tissue oxygen (StO2), and that RBC storage age does not influence the tissue response after ischaemic provocation, using near-infrared spectroscopy. PATIENTS AND METHODS: Twenty-four chronic anaemic haematology patients were included...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27899173/procoagulant-role-of-microparticles-in-routine-storage-of-packed-red-blood-cells-potential-risk-for-prothrombotic-post-transfusion-complications
#3
Htet Htet Aung, John-Paul Tung, Melinda M Dean, Robert L Flower, Natalie M Pecheniuk
During routine storage, packed red blood cells (PRBC) undergo biochemical and morphological changes including loss of red blood cell (RBC) membrane asymmetry and release of microparticles (MPs) bearing phosphatidylserine (PS), a procoagulant phospholipid. This study investigated the association between PRBC storage duration, MP profile and procoagulant activity. Leukodepleted PRBC-supernatant (PRBC-SN; n=13) was prepared at weekly intervals throughout storage. Phospholipid-dependent procoagulant activity, assessed using a factor X-activated clotting time (XACT) assay, decreased throughout storage (p<0...
November 26, 2016: Pathology
https://www.readbyqxmd.com/read/27896765/blood-bio-sampling-procedures-for-multiplex-biomarkers-studies
#4
Paul C Guest, Hassan Rahmoune
A major challenge in single or panel of biomarker discovery and validation is the inherent biological complexity underlying disease heterogeneity and inconsistent responses to treatment. Moreover, the lack of standardization in the sampling, processing, and storage of biological fluids such as plasma and serum disrupts the discovery and validation of blood-based biomarker tests in preclinical and clinical settings. This chapter presents a reproducible sample collection and handling procedure that aims to enhance analyte stability and ensure compatibility with the corresponding multiplex biomarker profiling platforms...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27896132/divergent-clinical-outcomes-of-alpha-glucosidase-enzyme-replacement-therapy-in-two-siblings-with-infantile-onset-pompe-disease-treated-in-the-symptomatic-or-pre-symptomatic-state
#5
Takashi Matsuoka, Yoshiyuki Miwa, Makiko Tajika, Madoka Sawada, Koichiro Fujimaki, Takashi Soga, Hideshi Tomita, Shigeru Uemura, Ichizo Nishino, Tokiko Fukuda, Hideo Sugie, Motomichi Kosuga, Torayuki Okuyama, Yoh Umeda
Pompe disease is an autosomal recessive, lysosomal glycogen storage disease caused by acid α-glucosidase deficiency. Infantile-onset Pompe disease (IOPD) is the most severe form and is characterized by cardiomyopathy, respiratory distress, hepatomegaly, and skeletal muscle weakness. Untreated, IOPD generally results in death within the first year of life. Enzyme replacement therapy (ERT) with recombinant human acid alpha glucosidase (rhGAA) has been shown to markedly improve the life expectancy of patients with IOPD...
December 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27893349/platelet-leucocyte-and-red-cell-derived-microparticles-in-stored-whole-blood-with-and-without-leucofiltration-with-and-without-ionising-radiation
#6
Shunnichi Saito, Kenneth E Nollet, Alain M Ngoma, Takako Ono, Hitoshi Ohto
BACKGROUND: Storage lesion, including microparticle formation, has been partially characterised in whole blood, but not in all combinations of pre-storage leucofiltration and/or irradiation. MATERIALS AND METHODS: Single-donor whole blood products were processed into four subunits: with and without leucofiltration, with and without X-irradiation (25 Gy). Platelet-, leucocyte-, and erythrocyte-derived microparticles and free haemoglobin were measured periodically throughout 42 days of storage...
November 7, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27889868/biobanking-of-different-body-fluids-within-the-frame-of-ivf-a-standard-operating-procedure-to-improve-reproductive-biology-research
#7
Michael Schenk, Berthold Huppertz, Barbara Obermayer-Pietsch, Darja Kastelic, Martina Hörmann-Kröpfl, Gregor Weiss
PURPOSE: The aim of the present study was to develop a standard operating procedure (SOP) for the collection, transport, and storage of human cumulus cells, follicular fluid, blood serum, seminal plasma, embryo culture supernatant, and embryo culture supernatant control obtained within the IVF process under approved protocols and written informed consent from participating patients. The SOP was developed at the Kinderwunsch Institut Schenk, Dobl, Austria, together with Biobank Graz of the Medical University of Graz, Austria...
November 26, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27884852/diagnostic-and-prognostic-biomarkers-in-the-rational-assessment-of-mesothelioma-diaphragm-study-protocol-of-a-prospective-multicentre-observational-study
#8
Selina Tsim, Caroline Kelly, Laura Alexander, Carol McCormick, Fiona Thomson, Rosie Woodward, John E Foster, David B Stobo, Jim Paul, Nick A Maskell, Anthony Chalmers, Kevin G Blyth
INTRODUCTION: Malignant pleural mesothelioma (MPM) is an asbestos-related cancer, which is difficult to diagnose. Thoracoscopy is frequently required but is not widely available. An accurate, non-invasive diagnostic biomarker would allow early specialist referral, limit diagnostic delays and maximise clinical trial access. Current markers offer insufficient sensitivity and are not routinely used. The SOMAmer proteomic classifier and fibulin-3 have recently demonstrated sensitivity and specificity exceeding 90% in retrospective studies...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27882555/a-randomized-controlled-pilot-study-of-vo2-max-testing-a-potential-model-for-measuring-relative-in-vivo-efficacy-of-different-red-blood-cell-products
#9
Elliott Bennett-Guerrero, Evelyn L Lockhart, Nicholas Bandarenko, Mary L Campbell, Michael J Natoli, Veronika K Jamnik, Timothy R Carter, Richard E Moon
BACKGROUND: Randomized trials, for example, RECESS, comparing "young" (median, 7-day) versus "middle-aged" (median, 28-day) red blood cells (RBCs), showed no difference in outcome. These data are important; however, they do not inform us about the safety and effectiveness of the oldest RBCs, which some patients receive. It may not be feasible to conduct a clinical trial randomizing patients to receive the oldest blood. Therefore, we propose strenuous exercise (VO2 max testing) as a model to study the relative efficacy to increase oxygen delivery to tissue of different RBC products, for example, extremes of storage duration...
November 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27881826/a-soft-wearable-microfluidic-device-for-the-capture-storage-and-colorimetric-sensing-of-sweat
#10
Ahyeon Koh, Daeshik Kang, Yeguang Xue, Seungmin Lee, Rafal M Pielak, Jeonghyun Kim, Taehwan Hwang, Seunghwan Min, Anthony Banks, Philippe Bastien, Megan C Manco, Liang Wang, Kaitlyn R Ammann, Kyung-In Jang, Phillip Won, Seungyong Han, Roozbeh Ghaffari, Ungyu Paik, Marvin J Slepian, Guive Balooch, Yonggang Huang, John A Rogers
Capabilities in health monitoring enabled by capture and quantitative chemical analysis of sweat could complement, or potentially obviate the need for, approaches based on sporadic assessment of blood samples. Established sweat monitoring technologies use simple fabric swatches and are limited to basic analysis in controlled laboratory or hospital settings. We present a collection of materials and device designs for soft, flexible, and stretchable microfluidic systems, including embodiments that integrate wireless communication electronics, which can intimately and robustly bond to the surface of the skin without chemical and mechanical irritation...
November 23, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27879483/comparison-of-ex-vivo-stability-of-copeptin-and-vasopressin
#11
Judith E Heida, Lianne S M Boesten, Esmée M Ettema, Anneke C Muller Kobold, Casper F M Franssen, Ron T Gansevoort, Debbie Zittema
BACKGROUND: Copeptin, part of the vasopressin precursor, is increasingly used as marker for vasopressin and is claimed to have better ex vivo stability. However, no study has directly compared the ex vivo stability of copeptin and vasopressin. METHODS: Blood of ten healthy volunteers was collected in EDTA tubes. Next, we studied the effect of various pre-analytical conditions on measured vasopressin and copeptin levels: centrifugation speed, short-term storage temperature and differences between whole blood and plasma, long-term storage temperature and repeated freezing and thawing...
November 23, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27877170/comparison-of-s-stercoralis-serology-performed-on-dried-blood-spots-and-on-conventional-serum-samples
#12
Fabio Formenti, Dora Buonfrate, Rosanna Prandi, Monica Marquez, Cintia Caicedo, Eleonora Rizzi, Angel G Guevara, Yosselin Vicuña, Francisco R Huerlo, Francesca Perandin, Zeno Bisoffi, Mariella Anselmi
Background: Dried blood spots (DBS) are used for epidemiological surveys on infectious diseases in settings where limited resources are available. In fact, DBS can help to overcome logistic difficulties for the collection, transport and storage of biological specimens. Objective: To evaluate the accuracy of Strongyloides stercoralis serology performed on DBS. Methods: A survey was proposed to children attending a school in the village of Borbon, Ecuador, and to their parents/guardians. Each participant gave consent to the collection of both serum and DBS specimens...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27875933/comparison-between-protein-repulsions-by-diblock-pla-peo-and-albumin-nanocoatings-using-owls
#13
Laurent Leclercq, Michel Vert
A previous investigation suggested that a surface bearing a rinsing-resistant depot (nanocoating) of albumin is more protein-repulsive than the same surface physically pegylated by a poly(D,L-lactic acid)-poly(ethylene oxide) diblock copolymer. To complement the study, Optical Waveguide Lightmode Spectroscopy was used to compare the mass and the thickness of protein depots from different systems, namely albumin alone at different concentrations, a mixture of albumin + fibrinogen + γ-globulin at their physiological concentrations, and sheep serum...
November 30, 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27872636/analyzing-brain-functions-by-subject-classification-of-functional-near-infrared-spectroscopy-data-using-convolutional-neural-networks-analysis
#14
Satoru Hiwa, Kenya Hanawa, Ryota Tamura, Keisuke Hachisuka, Tomoyuki Hiroyasu
Functional near-infrared spectroscopy (fNIRS) is suitable for noninvasive mapping of relative changes in regional cortical activity but is limited for quantitative comparisons among cortical sites, subjects, and populations. We have developed a convolutional neural network (CNN) analysis method that learns feature vectors for accurate identification of group differences in fNIRS responses. In this study, subject gender was classified using CNN analysis of fNIRS data. fNIRS data were acquired from male and female subjects during a visual number memory task performed in a white noise environment because previous studies had revealed that the pattern of cortical blood flow during the task differed between males and females...
2016: Computational Intelligence and Neuroscience
https://www.readbyqxmd.com/read/27872015/self-hardening-and-thermoresponsive-alpha-tricalcium-phosphate-pluronic-pastes
#15
Yassine Maazouz, Edgar B Montufar, Julien Malbert, Montserrat Espanol, Maria-Pau Ginebra
: Although calcium phosphate cements (CPCs) are used for bone regeneration in a wide range of clinical applications, various physicochemical phenomena are known to hinder their potential use in minimally invasive surgery or in highly vascularized surgical sites, mainly because of their lack of injectability or their low washout resistance. The present work shows that the combination of CPCs with an inverse-thermoresponsive hydrogel is a good strategy for finely tuning the cohesive and rheological properties of CPCs to achieve clinical acceptable injectability to prevent phase separation during implantation and cohesion to avoid washout of the paste...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27866271/paediatric-biobanking-dutch-experts-reflecting-on-appropriate-legal-standards-for-practice
#16
Elcke J Kranendonk, Raoul C Hennekam, M Corrette Ploem
: Large sets of data and human specimens, such as blood, tumour tissue and DNA, are deposited in biobanks for research purposes, preferably for long periods of time and with broadly defined research aims. Our research focuses on the retention of data and biological materials obtained from children. However important such paediatric biobanks may be, the privacy interests of the children involved and the related risks may not be ignored. The privacy issues arising from paediatric biobanks are the central focus of this article...
November 19, 2016: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27865649/extracellular-vesicles-in-transfusion-related-immunomodulation-and-the-role-of-blood-component-manufacturing
#17
REVIEW
Ruqayyah J Almizraq, Jerard Seghatchian, Jason P Acker
There is an emerging interest in the risks posed by the ability of blood transfusion to modulate the immune system of recipients. Observational trials suggest that RBC transfusions may be associated with increased morbidity and mortality, however studies demonstrating the deleterious consequences of transfusion-related immunomodulation have had conflicting results. Efforts to understand the biological mechanisms responsible for TRIM are under way, and are focusing on the role that the extracellular vesicles (EVs) that accumulate in a red cell concentrate (RCC) during storage may play...
October 28, 2016: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/27864142/glycogen-storage-disease-type-ib-neutrophils-exhibit-impaired-cell-adhesion-and-migration
#18
Goo-Young Kim, Young Mok Lee, Joon Hyun Kwon, Hyun Sik Jun, Janice Chou
Glycogen storage disease type Ib (GSD-Ib), characterized by impaired glucose homeostasis, neutropenia, and neutrophil dysfunction, is an inherited autosomal recessive disorder caused by a deficiency in the glucose-6-phosphate transporter (G6PT). Neutrophils play an essential role in the defense against invading pathogens. The recruitment of neutrophils towards the inflammation sites in response to inflammatory stimuli is a tightly regulated process involving rolling, adhesion, and transmigration. In this study, we investigated the role of G6PT in neutrophil adhesion and migration using in vivo and in vitro models...
November 15, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27852635/how-to-use%C3%A2-white-blood-cell-enzyme-assays
#19
James Davison
White blood cell (leucocyte) enzyme assays are an important part of the investigation of potential metabolic disorders, in particular, lysosomal storage disorders. It is imperative that appropriate tests are selected, and that knowledge of the limitations of these assays is applied to avoid erroneous conclusions about confirmation or exclusion of diagnoses.
November 15, 2016: Archives of Disease in Childhood. Education and Practice Edition
https://www.readbyqxmd.com/read/27847340/relevance-of-pre-analytical-blood-management-on-the-emerging-cardiovascular-protein-biomarkers-tweak-and-hmgb1-and-on-mirna-serum-and-plasma-profiling
#20
Daniela Basso, Andrea Padoan, Thomas Laufer, Vittorio Aneloni, Stefania Moz, Hannah Schroers, Michela Pelloso, Anna Saiz, Medea Krapp, Paola Fogar, Paola Cornoldi, Carlo-Federico Zambon, Elisa Rossi, Marco La Malfa, Alberto Marotti, Thomas Brefort, Tanja M Weis, Hugo A Katus, Mario Plebani
BACKGROUND: Disease-independent sources of biomarker variability include pre-analytical, analytical and biological variance. The aim of the present study was to evaluate whether the pre-analytical phase has any impact on the emerging heart disease TWEAK and HMGB1 protein markers and miRNA biomarkers, and whether peptidome profiling allows the identification of pre-analytical quality markers. METHODS: An assessment was made of sample type (serum, EDTA-Plasma, Citrate-Plasma, ACD-plasma, Heparin-plasma), temperature of sample storage (room temperature or refrigerated), time of sample storage (0...
November 12, 2016: Clinical Biochemistry
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