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Christian Guilleminault, Shehlanoor Huseni, Lauren Lo
A short lingual frenulum has been associated with difficulties in sucking, swallowing and speech. The oral dysfunction induced by a short lingual frenulum can lead to oral-facial dysmorphosis, which decreases the size of upper airway support. Such progressive change increases the risk of upper airway collapsibility during sleep. Clinical investigation of the oral cavity was conducted as a part of a clinical evaluation of children suspected of having sleep disordered breathing (SDB) based on complaints, symptoms and signs...
July 2016: ERJ Open Research
Alper N Erkan, Isilay Oz, Yunus K Terzi, Erdinc Aydin, Murat Ozkale, Seda Turkoglu Babakurban, Alper Koycu, Feride Iffet Sahin
OBJECTIVE: Ficolins are complement activating peptides that play a role in the initial host defense against infectious pathogens. In the present study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in the ficolin 2 gene (FCN2) and chronic adenotonsillitis in pediatric cases. STUDY DESIGN: Case-control study. METHODS: A total of 101 pediatric patients diagnosed with chronic adenotonsillitis and 100 healthy children were enrolled in the study...
August 2016: International Journal of Pediatric Otorhinolaryngology
Ajoy Mathew Varghese, P Naina, Alan T Cheng, Syed Kamran Asif, Mary Kurien
OBJECTIVES: To propose a novel endoscopic adenoid grading system using a rigid nasal endoscope and to study its correlation with the clinical diagnosis. METHODOLOGY: Prerecorded video clips of rigid nasal endoscopy taken during endoscopic adenoidectomy were retrieved. Otolaryngology consultants blinded to the clinical diagnosis of the child were presented these videos and asked to grade the adenoid hypertrophy as per the proposed endoscopic ACE (Airway/Choana/Eustachian tube) grading system...
April 2016: International Journal of Pediatric Otorhinolaryngology
A G Hirsch, X S Yan, A S Sundaresan, B K Tan, R P Schleimer, R C Kern, T L Kennedy, J S Greene, B S Schwartz
BACKGROUND: Chronic rhinosinusitis (CRS) has a broad range of comorbidities. Due to a lack of longitudinal studies, it is not known whether these comorbidities cause CRS, are promoted by CRS, or share a systemic disease process with CRS. OBJECTIVE: The objective of this study was to determine the risk of incident disease within 5 years after a new diagnosis of CRS with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP). METHODS: We conducted a case-control study nested within the longitudinal cohort of primary care patients in the Geisinger Clinic using electronic health record data...
December 2015: Allergy
Yung-An Tsou, Chia-Der Lin, Hui-Ying Hsu, Ming-Te Peng, Yu-Yi Kuo, Ni Tien, Ju-Pi Li, Chien-Kuo Wang, Hua-Shan Wu, Ming-Hsui Tsai, Chuan-Mu Chen, Chih-Ho Lai
BACKGROUND: Chronic adenoid infection by β-lactam-resistant Haemophilus influenzae type b (Hib) and biofilm formation contribute to adenoid hyperplasia. Middle ear disease consequently remains a critical issue in the pediatric population. The aim of this study was to investigate the correlation of Hib biofilm formation with middle ear effusion with adenoid hyperplasia (MEE-AH) and with pediatric obstructive sleep apnea (OSA). METHODS: A total of 384 patients with adenoidectomy from January 2008 to December 2012 were recruited in this investigation...
December 2015: Surgical Infections
Paola Pirelli, Maurizio Saponara, Christian Guilleminault
OBJECTIVE: The objective of this study was to prospectively evaluate the long-term efficacy of rapid maxillary expansion (RME) in a group of children with obstructive sleep apnea (OSA). MATERIAL AND METHOD: Thirty-one children diagnosed with OSA were involved in the study. These children had isolated maxillary narrowing and absence of enlarged adenotonsils at baseline. Twenty-three individuals (73% of the initial group) were followed up annually over a mean of 12 years after the completion of orthodontic treatment at a mean age of 8...
August 2015: Sleep Medicine
Hatem Badran, Mohamad Salah, Mohamed Fawzy, Amal Sayed, Doaa Ghaith
OBJECTIVE: To evaluate the role played by adenoids as a reservoir for infection in children assigned for adenoidectomy. METHODOLOGY: The study included 35 children with adenoid hypertrophy. All patients underwent clinical examination and adenoidectomy, adenotonsillectomy, or myringotomy with insertion of aeration tube according to indications. Surgical specimens were processed for conventional bacterial culture examination and to assay for biofilm formation. The obtained adherence values using spectrophotometer at 595 nm (OD595) was used to classify isolates according to its biofilm forming capacity...
July 2015: Annals of Otology, Rhinology, and Laryngology
Shima Javadi Nia, Vida Zarabi, Samileh Noorbakhsh, Mohammad Farhadi, Sahar Ghavidel Darestani
BACKGROUND: Since adenoids may act as a reservoir for bacteria, they can cause ear infection, recurrent otitis and recurrent adenotonsillitis. Therefore, adenotonsillectomy is an efficient method for reducing the number and severity of subsequent infections. OBJECTIVES: This study aimed to determine the Chlamydophila pneumonia infection by serological tests and performing PCR in the adenoid tissue, in children undergoing adenoid surgery and compare the results with normal children...
August 2014: Jundishapur Journal of Microbiology
Oğuz Güçlü, Alper Akçalı, Erkan Melih Sahin, Kazım Tekin, Ozan Barutçu, Müşerref Tatman Otkun, Fevzi Sefa Dereköy
BACKGROUND: There are insufficient data in the literature on the presence of Helicobacter pylori in tonsil and adenoid tissue of patients with only airway obstruction. This study examined the presence of H. pylori in surgical cases with airway obstruction or recurrent infection. AIMS: To investigate the relationship between H. pylori adenotonsillar colonisation and the frequency of adenotonsillitis and to compare paediatric and adult patients according to H. pylori tonsillar colonisation...
September 2013: Balkan Medical Journal
José Luiz Proença-Módena, Guilherme P Buzatto, Flávia E Paula, Tamara H Saturno, Luana S Delcaro, Mirela C Prates, Edwin Tamashiro, Fabiana C P Valera, Eurico Arruda, Wilma T Anselmo-Lima
OBJECTIVE: To evaluate the oscillations on the viral detection in adenotonsillar tissues from patients with chronic adenotonsillar diseases as an indicia of the presence of persistent viral infections or acute subclinical infections. STUDY DESIGN: Cross-sectional prospective study. SETTING: Tertiary hospital. METHODS: The fluctuations of respiratory virus detection were compared to the major climatic variables during a two-year period using adenoids and palatine tonsils from 172 children with adenotonsillar hypertrophy and clinical evidence of obstructive sleep apnoea syndrome or recurrent adenotonsillitis, without symptoms of acute respiratory infection (ARI), by TaqMan real-time PCR...
October 2014: International Journal of Pediatric Otorhinolaryngology
Iraj Aliakbari, Saeidollah Noohi, Seyed Abbas Safavi, Ali Goljanian Tabrizi, Mehdi Bolfion, Maryam Razaghi, Hossein Goudarzi, Hossein Dabiri
AIM: The aim of current study is to investigate whether tonsillar and/or adenoid tissue of patients with chronic adenotonsillitis plays a reservoir role for Helicobacter pylori (H. pylori) or Helicobacter hepaticus (H. hepaticus). BACKGROUND: Recently, there have been arguments ragarding Helicobacter pylori (H. pylori) being reserved in adenotonsillar tissue. PATIENTS AND METHODS: This study was performed with 90 patients with the diagnosis of chronic tonsillitis and adenoid hypertrophy, mean age 36 ± 22, 32 (36%) female and 58(64%) male...
2011: Gastroenterology and Hepatology From Bed to Bench
Abiodun Daud Olusesi, Nseobong Blessing Undie, Job Enema Amodu
BACKGROUND: Previous reports have established the association of allergy with adenoidal and tonsillar hypertrophy, and adenotonsillar hypertrophy is a well known co-morbid factor in patients with allergic rhinitis. Very little is known about the association of history of allergy with timing of first presentation in adenotonsillitis patients. SETTING: Tertiary care urban referral hospital. STUDY DESIGN: Descriptive analysis of prospectively collected data...
June 2013: International Journal of Pediatric Otorhinolaryngology
Aroor Rajeshwary, Sheethal Rai, Gangadhara Somayaji, Vidya Pai
BACKGROUND: Children with adenoid hypertrophy have been shown to harbor pathogenic bacteria in the nasopharynx despite antibiotics. Removal of the adenoid is associated with a reduction in the bacterial count. AIMS: The study was done to determine the bacteriology of the adenoid tissue in chronic adenotonsillitis and adenoid hypertrophy, and determine the antibiotic sensitivity of potential pathogens. MATERIALS AND METHODS: This is a descriptive study conducted on 100 patients aged between three and twelve years who underwent adenotonsillectomy/adenoidectomy...
February 2013: North American Journal of Medical Sciences
Bruce K Tan, Rakesh K Chandra, Jonathan Pollak, Atsushi Kato, David B Conley, Anju T Peters, Leslie C Grammer, Pedro C Avila, Robert C Kern, Walter F Stewart, Robert P Schleimer, Brian S Schwartz
BACKGROUND: Chronic rhinosinusitis (CRS) is a prevalent condition with underexplored risk factors. OBJECTIVES: We sought to determine CRS incidence and evaluate associations with a range of premorbid medical conditions for chronic rhinosinusitis without nasal polyps (CRSsNP) and chronic rhinosinusitis with nasal polyps (CRSwNP) using real-world clinical practice data. METHODS: Electronic health records data from 446,480 Geisinger Clinic primary care patients were used for a retrospective longitudinal cohort study for data from 2001-2010...
May 2013: Journal of Allergy and Clinical Immunology
Hulya Eyigor, Ustun Osma, Mete Eyigor, Mustafa Deniz Yilmaz, Berna Gultekin, Murat Telli, Atakan Ozturan, Meral Gultekin
BACKGROUND: The aim of this study was to investigate whether in children with middle ear effusions (MEE), adenoid and tonsil tissues are associated with human bocavirus (HBoV). MATERIALS AND METHODS: A total of 124 patients (56 females (45.2%) and 68 males (54.8%)) with chronic adenotonsillitis and serous otitis media under the age of 15 were recruited. Two hundered four samples (113 adenoid (55.4%), 68 tonsil (33.3%), and 23 middle ear effusion (11.3%)) were analyzed for the presence of HBoV using polymerase chain reaction (PCR)...
2013: Clinical Laboratory
Tiantian Ren, Dominique Ulrike Glatt, Tam Nhu Nguyen, Emma Kaitlynn Allen, Stephen V Early, Michele Sale, Birgit Winther, Martin Wu
Adenoid microbiota plays an important role in the development of various infectious and non-infectious diseases of the upper airways, such as otitis media, adenotonsillitis, rhinosinusitis and adenoid hypertrophy. Studies have suggested that adenoids could act as a potential reservoir of opportunistic pathogens. However, previous bacterial surveys of adenoids were mainly culture based and therefore might only provide an incomplete and potentially biased assessment of the microbial diversity. To develop an in-depth and comprehensive understanding of the adenoid microbial communities and test the 'pathogen reservoir hypothesis', we carried out a 16S rRNA based, culture-independent survey of bacterial communities on 67 human adenoids removed by surgery...
February 2013: Environmental Microbiology
Sema Koc, Metin Aytekin, Nihat Kalay, Mustafa Ozcetin, Turgay Burucu, Kerem Ozbek, Atac Celik, Hasan Kadi, Sefa Gulturk, Fatih Koc
OBJECTIVES: Adenotonsillar hypertrophy (ATH) is the most common cause of upper airway obstruction in children. Severe upper airway obstruction may have an effect on chronic alveolar hypoventilation, which consequently may lead to right ventricle (RV) dysfunction induced by hypoxemic pulmonary vasoconstriction. The investigators aimed to study RV function and mean pulmonary artery pressure (mPAP) in patients with ATH who were undergoing adenotonsillectomy by using tissue Doppler echocardiography (TDE)...
January 2012: International Journal of Pediatric Otorhinolaryngology
Sema Koc, Nurten Aksoy, Hasan Bilinc, Fazilet Duygu, Ismail Önder Uysal, Adnan Ekinci
OBJECTIVES: The aim of this study was to investigate serum paraoxonase, arylesterase activities along with determination of oxidative status via measurement of total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) in children with recurrent adenotonsillitis during pre- and post-adenotonsillectomy period and to compare results with data from healthy subjects. METHODS: We performed a prospective controlled trial on adenoidectomy and/or tonsillectomy patients...
November 2011: International Journal of Pediatric Otorhinolaryngology
Louise Amália de Moura, Ana Carolina D'Arelli de Oliveira, Gilberto de Araújo Pereira, Lílian Varanda Pereira
The objective of this study was to verify and describe, from a gender focus, the associations between gender and specific postoperative pain variables in pediatrics. This is a cross-sectional study of 77 children between 6 and 13 years of age (M=9 years; sd=2.2 years), ASA I and II, 77.9% from low-income classes, 68.8% boys and 32.8% girls. Data were collected on the first postoperative (1st PO) day through semi-structured interviews and four measurement scales. The main baseline diseases were adenotonsillitis and fractures...
August 2011: Revista da Escola de Enfermagem da U S P
Keehyun Park
Innate immunity involves the first line of the mucosal defense system. Homeostatic defense of the middle ear and Eustachian tube is maintained in part by molecules related to the innate immunity. The middle ear and tonsils are the organs related to the innate immunity. Recent attention has focused on the possibility that chronic otitis media and adenotonsillitis may represent a chronic infective state such as evidenced in conditions secondary to biofilms or small colony variants. The role of biofilms in the persistence of chronic mucosal-based ENT-related infections was first recognized in otitis media and adenotonsillitis...
2011: Advances in Oto-rhino-laryngology
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