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https://www.readbyqxmd.com/read/28536161/correction-for-evans-et-al-informing-antibiotic-treatment-decisions-evaluating-rapid-molecular-diagnostics-to-identify-susceptibility-and-resistance-to-carbapenems-against-acinetobacter-spp-in-primers-iii
#1
Scott R Evans, Andrea M Hujer, Hongyu Jiang, Carol B Hill, Kristine M Hujer, Jose R Mediavilla, Claudia Manca, Thuy Tien T Tran, T Nicholas Domitrovic, Paul G Higgins, Harald Seifert, Barry N Kreiswirth, Robin Patel, Michael R Jacobs, Liang Chen, Rangarajan Sampath, Thomas Hall, Christine Marzan, Vance G Fowler, Henry F Chambers, Robert A Bonomo
No abstract text is available yet for this article.
June 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28529090/continued-expansion-of-usa300-like-methicillin-resistant-staphylococcus-aureus-mrsa-among-hospitalized-patients-in-the-united-states
#2
Isabella A Tickler, Richard V Goering, Jose R Mediavilla, Barry N Kreiswirth, Fred C Tenover
We characterized spa types, SCCmec types, and antimicrobial resistance patterns of 516 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between 2011 and 2014 from nares and blood cultures of United States patients. Among nares isolates, 45 spa types were observed; 29.9% were t002/SCCmec II and 30.9% were t008/SCCmec IV. Among blood isolates, 40 spa types were identified; 24.4% were t002/SCCmec II and 39.9% were type t008/SCCmec IV. Compared to data from our 2009-2010 survey, the percentage of t008/SCCmec IV isolates from nares increased significantly (20...
May 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28520983/genomic-epidemiology-of-global-vim-producing-enterobacteriaceae
#3
Yasufumi Matsumura, Gisele Peirano, Rebekah Devinney, Patricia A Bradford, Mary R Motyl, Mark D Adams, Liang Chen, Barry Kreiswirth, Johann D D Pitout
Background: : International data on the molecular epidemiology of Enterobacteriaceae with VIM carbapenemases are limited. Methods: We performed short read (Illumina) WGS on a global collection of 89 VIM-producing clinical Enterobacteriaceae (2008-14). Results: VIM-producing (11 varieties within 21 different integrons) isolates were mostly obtained from Europe. Certain integrons with bla VIM were specific to a country in different species and clonal complexes (CCs) (In 87 , In 624 , In 916 and In 1323 ), while others had spread globally among various Enterobacteriaceae species (In 110 and In 1209 )...
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28507118/colistin-resistance-in-carbapenem-resistant-klebsiella-pneumoniae-mediated-by-chromosomal-integration-of-plasmid-dna
#4
Astrid V Cienfuegos-Gallet, Liang Chen, Barry N Kreiswirth, J Natalia Jiménez
Here we describe the spread of colistin resistance in clinical isolates of carbapenem-resistant-K. pneumoniae in Medellín, Colombia. Among 32 isolates collected between 2012 and 2014, 24 showed genetic alterations in mgrB Nineteen isolates belonged to ST512 (or its SLV) and harbored a novel 8.1-Kb hsdMSR insertion, indicating a clonal expansion of the resistant strain. The insertion region showed 100% identity to several plasmids, suggesting the colistin resistance is mediated by chromosomal integration of plasmid DNA...
May 15, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28482960/tuberculosis-disease-among-mexico-born-individuals-living-in-new-york-city-2001-2014
#5
N L Stennis, J S Meissner, D Bhavnani, B Kreiswirth, S Desai Ahuja
SETTING: Tuberculosis (TB) has decreased substantially in New York City (NYC), but progress has slowed in recent years. Continued declines will require novel approaches tailored to foreign-born populations. OBJECTIVE: To describe TB epidemiology among the Mexico-born population of NYC to inform interventions in this community. DESIGN: The study included NYC patients with TB disease identified from 2001 to 2014. Incidence rates were compared by country of birth groupings...
June 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28454653/strains-of-mycobacterium-tuberculosis-transmitting-infection-in-brazilian-households-and-those-associated-with-community-transmission-of-tuberculosis
#6
Solange Alves Vinhas, Edward C Jones-López, Rodrigo Ribeiro Rodrigues, Mary Gaeddert, Renata Lyrio Peres, Patricia Marques-Rodrigues, Paola Poloni Lobo de Aguiar, Laura Forsberg White, David Alland, Padmini Salgame, David Hom, Jerrold J Ellner, Reynaldo Dietze, Lauren F Collins, Elena Shashkina, Barry Kreiswirth, Moisés Palaci
Molecular epidemiologic studies have shown that the dynamics of tuberculosis transmission varies geographically. We sought to determine which strains of Mycobacterium tuberculosis (MTB) were infecting household contacts (HHC), and which were causing clusters of tuberculosis (TB) disease in Vitoria-ES, Brazil. A total of 741 households contacts (445 TST +) and 139 index cases were characterized according to the proportion of contacts in each household that had a tuberculin skin test positive: low (LT) (≤40% TST+), high (HT) (≥70% TST+) and (40-70% TST+) intermediate (IT) transmission...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28444224/pharmacodynamics-of-colistin-and-fosfomycin-a-treasure-trove-combination-combats-kpc-producing-klebsiella-pneumoniae
#7
Miao Zhao, Zackery P Bulman, Justin R Lenhard, Michael J Satlin, Barry N Kreiswirth, Thomas J Walsh, Amanda Marrocco, Phillip J Bergen, Roger L Nation, Jian Li, Jing Zhang, Brian T Tsuji
Objectives: KPC-producing Klebsiella pneumoniae are an emerging public health problem around the globe. We defined the combinatorial pharmacodynamics and ability to suppress resistance of two 'old' antibiotics, fosfomycin and colistin, in time-kill experiments and hollow-fibre infection models (HFIM). Methods: Two KPC-2-producing K. pneumoniae isolates were used: one susceptible to both colistin and fosfomycin (KPC 9A: MIC colistin 0.25 mg/L and MIC fosfomycin ≤8 mg/L) and the other resistant to colistin and susceptible to fosfomycin (KPC 5A: MIC colistin 64 mg/L and MIC fosfomycin 32 mg/L)...
April 21, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28428984/a-comparison-of-molecular-typing-methods-applied-to-enterobacter-cloacae-complex-hsp60-sequencing-rep-pcr-and-mlst
#8
Roberto A Viau, Lee M Kiedrowski, Barry N Kreiswirth, Mark Adams, Federico Perez, Dror Marchaim, Dubert M Guerrero, Keith S Kaye, Latania K Logan, Maria Virginia Villegas, Robert A Bonomo
Molecular typing using repetitive sequenced-based PCR (rep-PCR) and hsp60 sequencing were applied to a collection of diverse Enterobacter cloacae complex isolates. To determine the most practical method for reference laboratories, we analyzed 71 E. cloacae complex isolates from sporadic and outbreak occurrences originating from 4 geographic areas. While rep-PCR was more discriminating, hsp60 sequencing provided a broader and a more objective geographical tracking method similar to multilocus sequence typing (MLST)...
2017: Pathogens & Immunity
https://www.readbyqxmd.com/read/28409124/hospital-dissemination-of-tst-1-positive-clonal-complex-5-cc5-methicillin-resistant-staphylococcus-aureus
#9
Min Wang, Yi Zheng, Jose R Mediavilla, Liang Chen, Barry N Kreiswirth, Yajun Song, Ruifu Yang, Hong Du
Methicillin-resistant Staphylococcus aureus (MRSA), is one of the most prevalent clinical pathogens isolated from hospital settings, and has increasingly identified in community settings. In China, the SCCmecIII-ST239 strains are disseminated in different geographic regions, accounting for >75% of all MRSA isolates in some national studies. Here we characterized 150 non-duplicate MRSA isolates collected from February 2012 to May 2013 in a tertiary hospital in Suzhou, Eastern China, to explore the molecular epidemiology...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28350903/advancing-diagnostics-to-address-antibacterial-resistance-the-diagnostics-and-devices-committee-of-the-antibacterial-resistance-leadership-group
#10
Ephraim L Tsalik, Elizabeth Petzold, Barry N Kreiswirth, Robert A Bonomo, Ritu Banerjee, Ebbing Lautenbach, Scott R Evans, Kimberly E Hanson, Jeffrey D Klausner, Robin Patel
Diagnostics are a cornerstone of the practice of infectious diseases. However, various limitations frequently lead to unmet clinical needs. In most other domains, diagnostics focus on narrowly defined questions, provide readily interpretable answers, and use true gold standards for development. In contrast, infectious diseases diagnostics must contend with scores of potential pathogens, dozens of clinical syndromes, emerging pathogens, rapid evolution of existing pathogens and their associated resistance mechanisms, and the absence of gold standards in many situations...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28350898/leading-antibacterial-laboratory-research-by-integrating-conventional-and-innovative-approaches-the-laboratory-center-of-the-antibacterial-resistance-leadership-group
#11
Claudia Manca, Carol Hill, Andrea M Hujer, Robin Patel, Scott R Evans, Robert A Bonomo, Barry N Kreiswirth
The Antibacterial Resistance Leadership Group (ARLG) Laboratory Center (LC) leads the evaluation, development, and implementation of laboratory-based research by providing scientific leadership and supporting standard/specialized laboratory services. The LC has developed a physical biorepository and a virtual biorepository. The physical biorepository contains bacterial isolates from ARLG-funded studies located in a centralized laboratory and they are available to ARLG investigators. The Web-based virtual biorepository strain catalogue includes well-characterized gram-positive and gram-negative bacterial strains published by ARLG investigators...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28350896/the-antibacterial-resistance-leadership-group-progress-report-and-work-in-progress
#12
Henry F Chip Chambers, Heather R Cross, Scott R Evans, Barry N Kreiswirth, Vance G Fowler
The Antibacterial Resistance Leadership Group (ARLG), with funding from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, was created in June 2013. Its mission is to develop, prioritize, and implement a clinical research agenda that addresses the public health threat of antibacterial resistance. This article reports on the progress that the ARLG has made to date in fulfilling its mission. Since inception, the ARLG has received and reviewed >70 study proposals, initiated >30 studies, executed >300 agreements, included data from >7000 subjects, published >45 manuscripts, and provided opportunities for 26 mentees...
March 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28242667/in-vitro-selection-of-meropenem-resistance-among-ceftazidime-avibactam-resistant-meropenem-susceptible-klebsiella-pneumoniae-isolates-with-variant-kpc-3-carbapenemases
#13
Ryan K Shields, M Hong Nguyen, Ellen G Press, Liang Chen, Barry N Kreiswirth, Cornelius J Clancy
Ceftazidime-avibactam resistance is mediated by blaKPC-3 mutations, which restore carbapenem susceptibility. We subjected Klebsiella pneumoniae isolates with different blaKPC-3 mutations (n = 5) or wild-type blaKPC-3 (n = 2) to serial passages with meropenem. The meropenem MIC against each isolate increased. Mutations in the ompK36 porin gene evolved in 5 isolates. Among isolates with D179Y substitutions in KPC-3, blaKPC-3 mutations reverted to wild type, were replaced by new mutations, or were retained. Carbapenem treatment of ceftazidime-avibactam-resistant K...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28221115/mycobacterium-tuberculosis-infection-among-asian-elephants-in-captivity
#14
Gary Simpson, Ralph Zimmerman, Elena Shashkina, Liang Chen, Michael Richard, Carol M Bradford, Gwen A Dragoo, Rhonda L Saiers, Charles A Peloquin, Charles L Daley, Paul Planet, Apurva Narachenia, Barun Mathema, Barry N Kreiswirth
Although awareness of tuberculosis among captive elephants is increasing, antituberculosis therapy for these animals is not standardized. We describe Mycobacterium tuberculosis transmission between captive elephants based on whole genome analysis and report a successful combination treatment. Infection control protocols and careful monitoring of treatment of captive elephants with tuberculosis are warranted.
March 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28203549/microbiological-and-clinical-characteristics-of-hypermucoviscous-klebsiella-pneumoniae-isolates-associated-with-invasive-infections-in-china
#15
Yinjuan Guo, Shanshan Wang, Lingling Zhan, Ye Jin, Jingjing Duan, Zhihao Hao, Jingnan Lv, Xiuqin Qi, Liang Chen, Barry N Kreiswirth, Liangxing Wang, Fangyou Yu
A distinctive syndrome caused by hypermucoviscous Klebsiella pneumoniae (HMKP) including pyogenic liver abscess (PLA) is now becoming a globally emerging disease. In the present study, 22.8% (84/369) of K. pneumoniae clinical isolates associated with various types of invasive infections were identified as HMKP, with 45.2% associated with PLA. Multivariate regression analysis showed that male patients with 41-50 years, PLA, diabetes mellitus, and hypertension were independent risk factors for HMKP infections...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28167556/importance-of-clonal-complex-258-and-incfk2-like-plasmids-among-a-global-collection-of-klebsiella-pneumoniae-with-blakpc
#16
Gisele Peirano, Patricia A Bradford, Krystyna M Kazmierczak, Liang Chen, Barry N Kreiswirth, Johann D D Pitout
This study was designed to determine the global distribution of clonal complex (CC) 258 and IncFIIK2-like plasmids with blaKPC among 522 global Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae isolates. CC258 (i.e., ST258 [clades I and II], ST11, ST340, and ST512) and ST147 were statistically associated with IncFIIK2-like KPC-containing plasmids and may possess an epidemiological advantage over isolates that harbored non-IncF KPC-harboring plasmids.
April 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167555/global-molecular-epidemiology-of-imp-producing-enterobacteriaceae
#17
Yasufumi Matsumura, Gisele Peirano, Mary R Motyl, Mark D Adams, Liang Chen, Barry Kreiswirth, Rebekah DeVinney, Johann D D Pitout
International data on the molecular epidemiology of Enterobacteriaceae with IMP carbapenemases are lacking. We performed short-read (Illumina) whole-genome sequencing on a global collection of 38 IMP-producing clinical Enterobacteriaceae (2008 to 2014). IMP-producing Enterobacteriaceae (7 varieties within 11 class 1 integrons) were mainly present in the South Pacific and Asia. Specific blaIMP-containing integrons (In809 with blaIMP-4, In722 with blaIMP-6, and In687 with blaIMP-14) were circulating among different bacteria in countries such as Australia, Japan, and Thailand...
April 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167551/genomic-characterization-of-two-kpc-producing-klebsiella-isolates-collected-in-1997-in-new-york-city
#18
Brandon Eilertson, Liang Chen, Kalyan D Chavda, Barry N Kreiswirth
Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae have now become a global public health threat. However, the origin of this pandemic and the characterization of pre-2003 blaKPC-harboring plasmids remain unknown. Here we used next-generation sequencing to characterize two KPC-2-producing K. pneumoniae and Kmichiganensis isolates collected from a New York City hospital in 1997. Although identified in two different Klebsiella species, the blaKPC-2 gene was harbored by Tn4401b transposons on two highly similar IncN plasmids...
April 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167549/new-polymyxin-b-dosing-strategies-to-fortify-old-allies-in-the-war-against-kpc-2-producing-klebsiella-pneumoniae
#19
Zackery P Bulman, Michael J Satlin, Liang Chen, Barry N Kreiswirth, Beom Soo Shin, Thomas J Walsh, Patricia N Holden, Alan Forrest, Roger L Nation, Jian Li, Brian T Tsuji
Pharmacodynamics of a polymyxin B, meropenem, and rifampin triple combination were examined against Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae (KPC-Kp) ST258. In time-kill experiments against three KPC-Kp isolates, triple combination generated 8.14, 8.19, and 8.29 log10 CFU/ml reductions within 24 h. In the hollow-fiber infection model, the triple combination caused maximal killing of 5.16 log10 CFU/ml at 78 h and the time required for regrowth was more than doubled versus the 2-drug combinations...
April 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28167547/multicenter-clinical-and-molecular-epidemiological-analysis-of-bacteremia-due-to-carbapenem-resistant-enterobacteriaceae-cre-in-the-cre-epicenter-of-the-united-states
#20
Michael J Satlin, Liang Chen, Gopi Patel, Angela Gomez-Simmonds, Gregory Weston, Angela C Kim, Susan K Seo, Marnie E Rosenthal, Steven J Sperber, Stephen G Jenkins, Camille L Hamula, Anne-Catrin Uhlemann, Michael H Levi, Bettina C Fries, Yi-Wei Tang, Stefan Juretschko, Albert D Rojtman, Tao Hong, Barun Mathema, Michael R Jacobs, Thomas J Walsh, Robert A Bonomo, Barry N Kreiswirth
Although the New York/New Jersey (NY/NJ) area is an epicenter for carbapenem-resistant Enterobacteriaceae (CRE), there are few multicenter studies of CRE from this region. We characterized patients with CRE bacteremia in 2013 at eight NY/NJ medical centers and determined the prevalence of carbapenem resistance among Enterobacteriaceae bloodstream isolates and CRE resistance mechanisms, genetic backgrounds, capsular types (cps), and antimicrobial susceptibilities. Of 121 patients with CRE bacteremia, 50% had cancer or had undergone transplantation...
April 2017: Antimicrobial Agents and Chemotherapy
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