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https://www.readbyqxmd.com/read/28655059/association-of-autonomic-dysfunction-with-disease-progression-and-survival-in-parkinson-disease
#1
Eduardo De Pablo-Fernandez, Carmen Tur, Tamas Revesz, Andrew J Lees, Janice L Holton, Thomas T Warner
Importance: Evidence suggests that development of autonomic dysfunction (AutD) may negatively affect disease course and survival in patients with synucleinopathies. However, the few available studies on Parkinson disease (PD) have conflicting results, comprise a small number of patients, have short follow-up periods, and lack pathologic confirmation of the diagnosis. Objective: To examine the association of time of onset of AutD with disease progression and survival in PD...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28655041/game-based-augmented-visual-feedback-for-enlarging-speech-movements-in-parkinson-s-disease
#2
Yana Yunusova, Elaine Kearney, Madhura Kulkarni, Brandon Haworth, Melanie Baljko, Petros Faloutsos
Purpose: The purpose of this pilot study was to demonstrate the effect of augmented visual feedback on acquisition and short-term retention of a relatively simple instruction to increase movement amplitude during speaking tasks in patients with dysarthria due to Parkinson's disease (PD). Method: Nine patients diagnosed with PD, hypokinetic dysarthria, and impaired speech intelligibility participated in a training program aimed at increasing the size of their articulatory (tongue) movements during sentences...
June 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28655039/speech-motor-sequence-learning-effect-of-parkinson-disease-and-normal-aging-on-dual-task-performance
#3
Jason A Whitfield, Alexander M Goberman
Purpose: Everyday communication is carried out concurrently with other tasks. Therefore, determining how dual tasks interfere with newly learned speech motor skills can offer insight into the cognitive mechanisms underlying speech motor learning in Parkinson disease (PD). The current investigation examines a recently learned speech motor sequence under dual-task conditions. Method: A previously learned sequence of 6 monosyllabic nonwords was examined using a dual-task paradigm...
June 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28655027/zolpidem-for-the-treatment-of-neurologic-disorders-a-systematic-review
#4
Martin N Bomalaski, Edward S Claflin, Whitney Townsend, Mark D Peterson
Importance: Given its selective action on the ω1 subtype of the γ-aminobutyric acid A receptor, zolpidem tartrate presents a potential treatment mechanism for other neurologic disorders. Objective: To synthesize studies that used zolpidem to treat neurologic disorders. Evidence Review: Eligibility criteria included any published English-language article that examined the use of zolpidem for noninsomnia neurologic disorders in humans for all dates up to March 20, 2015...
June 26, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28654941/internally-versus-externally-cued-speech-in-parkinson-s-disease-and-cerebellar-disease
#5
Phil Weir-Mayta, Kristie A Spencer, Tanya L Eadie, Kathryn Yorkston, Sara Savaglio, Chris Woollcott
Purpose: The purpose of this study was to examine the effects of an internally versus externally cued speech task on perceived understandability and naturalness in speakers with Parkinson's disease (PD) and cerebellar disease (CD). Method: Sentences extracted from a covertly recorded conversation (internally cued) were compared to the same sentences read aloud (externally cued) by speakers with PD and a clinical comparison group of speakers with CD. Experienced listeners rated the speech samples using a visual analog scale for the perceptual dimensions of understandability and naturalness...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654940/consonant-acoustics-in-parkinson-s-disease-and-multiple-sclerosis-comparison-of-clear-and-loud-speaking-conditions
#6
Kris Tjaden, Vincent Martel-Sauvageau
Purpose: The impact of clear speech or an increased vocal intensity on consonant spectra was investigated for speakers with mild dysarthria secondary to multiple sclerosis or Parkinson's disease and healthy controls. Method: Sentences were read in habitual, clear, and loud conditions. Spectral moment coefficients were obtained for word-initial and word-medial /s/, /ʃ/, /t/, and /k/. Global production differences among conditions were confirmed with measures of vocal intensity and articulation rate...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654939/speech-versus-speaking-the-experiences-of-people-with-parkinson-s-disease-and-implications-for-intervention
#7
Kathryn Yorkston, Carolyn Baylor, Deanna Britton
Purpose: In this project, we explore the experiences of people who report speech changes associated with Parkinson's disease as they describe taking part in everyday communication situations and report impressions related to speech treatment. Method: Twenty-four community-dwelling adults with Parkinson's disease took part in face-to-face, semistructured interviews. Qualitative research methods were used to code and develop themes related to the interviews. Results: Two major themes emerged...
June 22, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28654017/does-vitamin-c-influence-neurodegenerative-diseases-and-psychiatric-disorders
#8
REVIEW
Joanna Kocot, Dorota Luchowska-Kocot, Małgorzata Kiełczykowska, Irena Musik, Jacek Kurzepa
Vitamin C (Vit C) is considered to be a vital antioxidant molecule in the brain. Intracellular Vit C helps maintain integrity and function of several processes in the central nervous system (CNS), including neuronal maturation and differentiation, myelin formation, synthesis of catecholamine, modulation of neurotransmission and antioxidant protection. The importance of Vit C for CNS function has been proven by the fact that targeted deletion of the sodium-vitamin C co-transporter in mice results in widespread cerebral hemorrhage and death on post-natal day one...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28653995/nutrinet-a-deep-learning-food-and-drink-image-recognition-system-for-dietary-assessment
#9
Simon Mezgec, Barbara Koroušić Seljak
Automatic food image recognition systems are alleviating the process of food-intake estimation and dietary assessment. However, due to the nature of food images, their recognition is a particularly challenging task, which is why traditional approaches in the field have achieved a low classification accuracy. Deep neural networks have outperformed such solutions, and we present a novel approach to the problem of food and drink image detection and recognition that uses a newly-defined deep convolutional neural network architecture, called NutriNet...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28653979/hypermethylation-of-synphilin-1-alpha-synuclein-interacting-protein-sncaip-gene-in-the-cerebral-cortex-of-patients-with-sporadic-parkinson-s-disease
#10
Khashayar Dashtipour, Ali Tafreshi, Charles Adler, Thomas Beach, Xin Chen, Geidy Serrano, Stephanie Tashiro, Charles Wang
OBJECTIVE: To determine and compare DNA methylation patterns between patients with Parkinson's disease (PD) and age- and sex-similar matched non-PD controls. BACKGROUND: Epigenetic regulation is one of the major mechanisms for an organism to respond to the environment through changes in gene expression and has been implicated in numerous disease processes. We would like to examine epigenetic modification patterns that may predispose or protect against PD. METHODS: Frozen tissue samples of the human cerebral cortex from 12 PD patients and 12 subjects without PD pathology were obtained...
June 27, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28653925/nsaids-ameliorate-cognitive-and-motor-impairment-in-a-model-of-parkinsonism-induced-by-chlorpromazine
#11
Sadaf Naeem, Rahila Ikram, Saira Saeed Khan, Sadia Saleem Rao
Parkinson's disease (PD) is a long-lasting neurodegenerative brain disease. It is characterized by a gradual decline in motor and non motor symptoms especially postural instability, tremors and memory impairment with localized loss of neurons mainly in the Substantia nigra. In the current research we evaluated the effects of Non-steroidal anti inflammatory drugs (NSAIDs) on motor coordination and memory in chlorpromazine (CPZ) induced Parkinson's experimental model. Intraperitoneal (i.p.) injection of CPZ (3 mg/kg) was given to all rats for 21 days to induce Parkinson like symptoms; ibuprofen (40mg/kg/day) and celecoxib (20mg/kg) were administered 30 minutes after CPZ injection...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28653647/advances-in-progressive-supranuclear-palsy-new-diagnostic-criteria-biomarkers-and-therapeutic-approaches
#12
REVIEW
Adam L Boxer, Jin-Tai Yu, Lawrence I Golbe, Irene Litvan, Anthony E Lang, Günter U Höglinger
Progressive supranuclear palsy (PSP), previously believed to be a common cause of atypical parkinsonism, is now recognised as a range of motor and behavioural syndromes that are associated with a characteristic 4-repeat tau neuropathology. New research criteria that recognise early presentations of PSP and operationalise diagnosis of the full spectrum of clinical phenotypes have been reported. The Movement Disorders Society PSP diagnostic criteria include syndromes with few or mild symptoms that are suggestive of underlying PSP pathology and could provide an opportunity for earlier therapeutic interventions in the future...
July 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28653552/the-agency-of-patients-and-carers-in-medical-care-and-self-care-technologies-for-interacting-with-doctors
#13
Francisco Nunes, Tariq Andersen, Geraldine Fitzpatrick
People living with Parkinson's disease engage in self-care for most of the time but, two or three times a year, they meet with doctors to re-evaluate the condition and adjust treatment. Patients and (informal) carers participate actively in these encounters, but their engagement might change as new patient-centred technologies are integrated into healthcare infrastructures. Drawing on a qualitative study that used observations and interviews to investigate consultations, and digital ethnography to understand interactions in an online community, we describe how patients and carers living with Parkinson's participate in the diagnosis and treatment decisions, engage in discussions to learn about certain topics, and address inappropriate medication...
June 1, 2017: Health Informatics Journal
https://www.readbyqxmd.com/read/28653373/association-between-parkinson-s-disease-and-diabetes-data-from-nedices-study
#14
E De Pablo-Fernandez, F Sierra-Hidalgo, J Benito-León, F Bermejo-Pareja
BACKGROUND: Despite growing evidence showing an association between Parkinson's disease (PD) and diabetes, epidemiological studies have shown conflicting results. AIMS OF THE STUDY: To evaluate the association between PD and diabetes and the impact of diabetes duration in this association in an elderly (≥65 years) Spanish population. METHODS: Data for this cross-sectional population-based analysis were obtained from NEDICES study. Subjects were identified from census list...
June 26, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28653213/external-input-for-gait-in-people-with-parkinson-s-disease-with-and-without-freezing-of-gait-one-size-does-not-fit-all
#15
Pieter Ginis, Elke Heremans, Alberto Ferrari, Esther M J Bekkers, Colleen G Canning, Alice Nieuwboer
Cueing or feedback provided when gait deviates from a predefined goal (intelligent input) can now be provided with wearable technology for Parkinson's disease (PD). As people with and without freezing of gait (FOG) have distinct cognitive profiles, they may respond differently to various types of input. This study compared the effects of four input modalities during prolonged walking and explored the relationship with cognition, subjective preference, and FOG. Participants (15 with and 13 without FOG) walked 30 min while exposed to continuous cueing; intelligent cueing; intelligent feedback; or no input...
June 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28653210/lateralized-microstructural-changes-in-early-stage-parkinson-s-disease-in-anterior-olfactory-structures-but-not-in-substantia-nigra
#16
N Joshi, T M Rolheiser, J D Fisk, J R McKelvey, K Schoffer, G Phillips, M Armstrong, M N Khan, R A Leslie, B Rusak, H A Robertson, K P Good
Parkinson's disease (PD) is a progressive neurological disorder characterized by motor symptoms as well as severe deficits in olfactory function and microstructural changes in olfactory brain regions. Because of the evidence of asymmetric neuropathological features in early-stage PD, we examined whether lateralized microstructural changes occur in olfactory brain regions and the substantia nigra in a group of early-stage PD patients. Using diffusion tensor imaging (DTI) and the University of Pennsylvania Smell Identification Test (UPSIT), we assessed 24 early-stage PD patients (Hoehn and Yahr stage 1 or 2) and 26 healthy controls (HC)...
June 26, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28652971/loss-of-integrity-and-atrophy-in-cingulate-structural-covariance-networks-in-parkinson-s-disease
#17
Laura J de Schipper, Jeroen van der Grond, Johan Marinus, Johanna M L Henselmans, Jacobus J van Hilten
BACKGROUND: In Parkinson's disease (PD), the relation between cortical brain atrophy on MRI and clinical progression is not straightforward. Determination of changes in structural covariance networks - patterns of covariance in grey matter density - has shown to be a valuable technique to detect subtle grey matter variations. We evaluated how structural network integrity in PD is related to clinical data. METHODS: 3 Tesla MRI was performed in 159 PD patients. We used nine standardized structural covariance networks identified in 370 healthy subjects as a template in the analysis of the PD data...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28652929/tnf-%C3%AE-and-beyond-rapid-mitochondrial-dysfunction-mediates-tnf-%C3%AE-induced-neurotoxicity
#18
Ashley E Russell, Danielle N Doll, Saumyendra N Sarkar, James W Simpkins
This short communication describes our research which demonstrates that TNF-α causes a rapid decline in mitochondrial function, leading to neuronal cell death. As such, this neurotoxic proinflammatory cytokine may play a role in brain damage from stroke and neurodegeneration in chronic conditions such as Alzheimer's disease (AD) and Parkinson's disease. We have extended this initial observation by demonstrating that TNF-α stimulates a microRNA (miR-34a) which we have shown reduces five key proteins in the mitochondrial electron transport chain through base-pair complementarity...
December 2016: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/28652749/sleep-apnea-leading-to-parkinson-s-disease-an-important-association
#19
COMMENT
Muhammad Nabeel Shafqat, Muhammad Aadil, Maria Shoaib
No abstract text is available yet for this article.
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28652714/the-safety-issues-and-hardware-related-complications-of-deep-brain-stimulation-therapy-a-single-center-retrospective-analysis-of-478-patients-with-parkinson-s-disease
#20
Jing Zhang, Tao Wang, Chen-Cheng Zhang, Kristina Zeljic, Shikun Zhan, Bo-Min Sun, Dian-You Li
INTRODUCTION: Deep brain stimulation (DBS) is a well-established therapy for the treatment of advanced Parkinson's disease (PD) in patients experiencing motor fluctuations and medication-refractory tremor. Despite the relative tolerability and safety of this procedure, associated complications and unnatural deaths are still unavoidable. METHODS: In this study, hardware-related complications and the causes of unnatural death were retrospectively analyzed in 478 patients with PD who were treated with DBS...
2017: Clinical Interventions in Aging
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