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https://www.readbyqxmd.com/read/28531270/utilization-of-quantitative-susceptibility-mapping-for-direct-targeting-of-the-subthalamic-nucleus-during-deep-brain-stimulation-surgery
#1
Jonathan Rasouli, Ritesh Ramdhani, Fedor E Panov, Alexey Dimov, Yan Zhang, Catherine Cho, Yi Wang, Brian Harris Kopell
BACKGROUND: Deep brain stimulation of the subthalamic nucleus (STN) has demonstrated efficacy in improving motor disability in Parkinson's disease. The recently developed quantitative susceptibility mapping (QSM) technique, which can accurately map iron deposits in deep brain nuclei, promises precise targeting of the STN. OBJECTIVE: To demonstrate the use of QSM to target STN effectively by correlating with classical physiological-based targeting measures in a prospective study...
May 21, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28531237/burden-of-neurological-diseases-in-the-us-revealed-by-web-searches
#2
Ricardo Baeza-Yates, Puneet Mohan Sangal, Pablo Villoslada
BACKGROUND: Analyzing the disease-related web searches of Internet users provides insight into the interests of the general population as well as the healthcare industry, which can be used to shape health care policies. METHODS: We analyzed the searches related to neurological diseases and drugs used in neurology using the most popular search engines in the US, Google and Bing/Yahoo. RESULTS: We found that the most frequently searched diseases were common diseases such as dementia or Attention Deficit/Hyperactivity Disorder (ADHD), as well as medium frequency diseases with high social impact such as Parkinson's disease, MS and ALS...
2017: PloS One
https://www.readbyqxmd.com/read/28531191/exogenous-expression-of-drp1-plays-neuroprotective-roles-in-the-alzheimer-s-disease-in-the-a%C3%AE-42-transgenic-drosophila-model
#3
Fengshou Lv, Xiaopeng Yang, Chuanju Cui, Chunhe Su
BACKGROUND: Alzheimer's disease (AD) is one of the most common neurodegenerative disorders. Recent studies have shown that mitochondrial dysfunction is a causative factor of AD. Drp1 (Dynamin-related protein 1), a regulator of mitochondrial fission, shows neuroprotective effects on Parkinson's disease. In this study, we investigate the effect and mechanism of Drp1 on Aβ42 transgenic Drosophila. METHODS: Elav-gal4/UAS>Aβ42 transgenic Drosophila model was constructed using Elav-gal4 promoter...
2017: PloS One
https://www.readbyqxmd.com/read/28531171/no-relevant-association-of-kinematic-gait-parameters-with-health-related-quality-of-life-in-parkinson-s-disease
#4
Kristina Bettecken, Felix Bernhard, Jennifer Sartor, Markus A Hobert, Marc Hofmann, Till Gladow, Janet M T van Uem, Inga Liepelt-Scarfone, Walter Maetzler
BACKGROUND: Health-related Quality of Life (HrQoL) is probably the most important outcome parameter for the evaluation and management of chronic diseases. As this parameter is subjective and prone to bias, there is an urgent need to identify objective surrogate markers. Gait velocity has been shown to be associated with HrQoL in numerous chronic diseases, such as Parkinson's disease (PD). With the development and wide availability of simple-to-use wearable sensors and sophisticated gait algorithms, kinematic gait parameters may soon be implemented in clinical routine management...
2017: PloS One
https://www.readbyqxmd.com/read/28530779/predictive-factors-for-early-hospital-readmission-and-1-year-mortality-in-elder-patients-following-surgical-treatment-of-a-hip-fracture
#5
Hakan Sofu, Hanifi Üçpunar, Yalkın Çamurcu, Serda Duman, Mehmet Nuri Konya, Sarper Gürsu, Vedat Şahin
BACKGROUND: Early hospital readmission after surgically treated hip fracture is a common entity, often involving an adverse event and causing strains on an already overburdened healthcare system. The main purposes of the present study were to determine the 30-day readmission rate, analyze the predictive factors for early hospital readmissions, and assess 1-year mortality following surgical treatment of hip fracture in elderly patients. Retrospective case-control study. METHODS: In total, 517 patients with a mean age of 74 years were evaluated...
May 2017: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/28530089/use-of-low-frequency-repetitive-transcranial-magnetic-stimulation-to-reduce-context-dependent-learning-in-people-with-parkinson-s-disease
#6
Ya-Yun Lee, Beth E Fisher
BACKGROUND: Compared with age-matched non-disabled adults, people with Parkinson's disease (PD) demonstrated greater context-dependent learning, a phenomenon in which an individual shows inferior motor performance when the testing environmental context is different from the original practice context. Additionally, enhanced context- dependency has been shown to be associated with an increased activation of the dorsolateral prefrontal cortex (DLPFC). AIM: This study aimed to determine whether context-dependent learning in people with PD could be reduced by decreasing DLPFC activation with low frequency repetitive transcranial magnetic stimulation (rTMS)...
May 22, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28529891/biomonitorization-of-iron-accumulation-in-the-substantia-nigra-from-lewy-body-disease-patients
#7
Belén Fernández, Isidro Ferrer, Fernando Gil, Sabine Hilfiker
Iron levels in the healthy human brain are known to be high in certain areas such as the substantia nigra (SN), and increase further with age. In addition, there is some evidence for a further increase in iron load in the SN of Parkinson's disease (PD) patients as compared to controls, which correlates with motor disability. Here, we have analyzed total iron levels in cells as well as mouse and human brain samples by atomic absorption spectroscopy (AAS). Our data indicate that iron load is more pronounced in cells with dopaminergic features...
2017: Toxicology Reports
https://www.readbyqxmd.com/read/28529878/neuroimaging-in-pre-motor-parkinson-s-disease
#8
REVIEW
Thomas R Barber, Johannes C Klein, Clare E Mackay, Michele T M Hu
The process of neurodegeneration in Parkinson's disease begins long before the onset of clinical motor symptoms, resulting in substantial cell loss by the time a diagnosis can be made. The period between the onset of neurodegeneration and the development of motoric disease would be the ideal time to intervene with disease modifying therapies. This pre-motor phase can last many years, but the lack of a specific clinical phenotype means that objective biomarkers are needed to reliably detect prodromal disease...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28529829/connecting-ca-2-and-lysosomes-to-parkinson-disease
#9
Bethan S Kilpatrick
The neurodegenerative movement disorder Parkinson disease (PD) is prevalent in the aged population. However, the underlying mechanisms that trigger disease are unclear. Increasing work implicates both impaired Ca(2+) signalling and lysosomal dysfunction in neuronal demise. Here I aim to connect these distinct processes by exploring the evidence that lysosomal Ca(2+) signalling is disrupted in PD. In particular, I highlight defects in lysosomal Ca(2+) content and signalling through NAADP-regulated two-pore channels in patient fibroblasts harbouring mutations in the PD-linked genes, GBA1 and LRRK2...
June 1, 2016: Messenger
https://www.readbyqxmd.com/read/28529828/two-pore-channels-and-parkinson-s-disease-where-s-the-link
#10
Pilar Rivero-Ríos, Belén Fernández, Jesús Madero-Pérez, María Romo Lozano, Sabine Hilfiker
Two-pore channels are endolysosomal Ca(2+) release channels involved in proper trafficking to and from those organelles. They are the likely targets for the Ca(2+)-mobilizing messenger NAADP, and are further regulated by a variety of mechanisms including phosphoinositide levels and Rab proteins. As discussed here, recent studies highlight a role for these channels in the pathomechanism(s) underlying Parkinson's disease, with important implications for possible alternative treatment strategies.
June 1, 2016: Messenger
https://www.readbyqxmd.com/read/28529827/deviant-lysosomal-ca-2-signalling-in-neurodegeneration-an-introduction
#11
Sandip Patel
Lysosomes are key acidic Ca(2+) stores. The principle Ca(2+)-permeable channels of the lysosome are TRP mucolipins (TRPMLs) and NAADP-regulated two-pore channels (TPCs). Recent studies, reviewed in this collection, have linked numerous neurodegenerative diseases to both gain and loss of function of TRPMLs/TPCs, as well as to defects in acidic Ca(2+) store content. These diseases span rare lysosomal storage disorders such as Mucolipidosis Type IV and Niemann-Pick disease, type C, through to more common ones such as Alzheimer and Parkinson disease...
June 1, 2016: Messenger
https://www.readbyqxmd.com/read/28529730/effect-of-low-versus-high-frequency-stimulation-on-freezing-of-gait-and-other-axial-symptoms-in-parkinson-patients-with-bilateral-stn-dbs-a-mini-review
#12
REVIEW
Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman, Peter Warnke
Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on improving freezing of gait (FOG) and other axial symptoms, including speech and swallowing function, in Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN DBS). However, other studies failed to confirm this. It seems not clear what determines the difference in response to LFS...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28528896/clinical-effects-of-air-pollution-on-the-central-nervous-system-a-review
#13
REVIEW
Robin M Babadjouni, Drew M Hodis, Ryan Radwanski, Ramon Durazo, Arati Patel, Qinghai Liu, William J Mack
The purpose of this review is to describe recent clinical and epidemiological studies examining the adverse effects of urban air pollution on the central nervous system (CNS). Air pollution and particulate matter (PM) are associated with neuroinflammation and reactive oxygen species (ROS). These processes affect multiple CNS pathways. The conceptual framework of this review focuses on adverse effects of air pollution with respect to neurocognition, white matter disease, stroke, and carotid artery disease. Both children and older individuals exposed to air pollution exhibit signs of cognitive dysfunction...
May 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28528805/acute-response-of-non-motor-symptoms-to-subthalamic-deep-brain-stimulation-in-parkinson-s-disease
#14
Margherita Fabbri, Miguel Coelho, Leonor Correia Guedes, Mario M Rosa, Daisy Abreu, Nilza Gonçalves, Angelo Antonini, Joaquim J Ferreira
BACKGROUND: Subthalamic deep brain stimulation (STN-DBS) is an established treatment for the motor complications of Parkinson's disease (PD) and may have beneficial effects on non-motor symptoms (NMS). However, the acute effect of STN stimulation on NMS has only been explored in small PD cohorts with short post-surgical follow-up. OBJECTIVE: To study NMS response to an acute stimulation challenge in an STN-DBS PD population with a medium/long-term post-surgical follow-up...
May 8, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28528804/an-interactive-videogame-for-arm-and-hand-exercise-in-people-with-parkinson-s-disease-a-randomized-controlled-trial
#15
Natalie E Allen, Jooeun Song, Serene S Paul, Stuart Smith, Jonathan O'Duffy, Matthew Schmidt, Rachelle Love, Catherine Sherrington, Colleen G Canning
INTRODUCTION: People with Parkinson's disease (PD) have difficulty performing upper extremity (UE) activities. The aim of this study was to investigate if exergames targeting the UE improve arm and hand activities and impairments and to establish the acceptability and feasibility of these games in people with PD. METHODS: Two tablet-based exergames were developed which were controlled with finger movements or unimanual whole arm movements. Participants with PD were randomized to an exergame (n = 19) or control (n = 19) group...
May 15, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28528803/understanding-parkinson-disease-in-sub-saharan-africa-a-call-to-action-for-the-international-neurologic-community
#16
EDITORIAL
James H Bower
No abstract text is available yet for this article.
May 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28528366/cdk5-mediated-phosphorylation-dependent-ubiquitination-and-degradation-of-e3-ubiquitin-ligases-gp78-accelerates-neuronal-death-in-parkinson-s-disease
#17
Qingzhi Wang, Fengjuan Jiao, Pei Zhang, Jianguo Yan, Zheng Zhang, Feng He, Qian Zhang, Zexi Lv, Xiang Peng, Hongwei Cai, Bo Tian
The molecular mechanisms responsible for the loss of dopaminergic neurons in Parkinson's disease (PD) remain obscure. Loss of function of E3 ubiquitin ligases is associated with mitochondria dysfunction, dysfunction of protein degradation, and α-synuclein aggregation, which are major contributors to neurodegeneration in PD. Recent research has thus focused on E3 ubiquitin ligase glycoprotein 78 (GP78); however, the role of GP78 in PD pathogenesis remains unclear. Notably, cyclin-dependent kinase 5 (CDK5) controls multiple cellular events in postmitotic neurons, and CDK5 activity has been implicated in the pathogenesis of PD...
May 20, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28527958/treadmill-exercise-produces-neuroprotective-effects-in-a-murine-model-of-parkinson-s-disease-by-regulating-the-tlr2-myd88-nf-%C3%AE%C2%BAb-signaling-pathway
#18
Jung-Hoon Koo, Yong-Chul Jang, Dong-Ju Hwang, Hyun-Seob Um, Nam-Hee Lee, Jae-Hoon Jung, Joon-Yong Cho
Parkinson's disease (PD) is characterized by progressive dopamine depletion and a loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Treadmill exercise is a promising non-pharmacological approach for reducing the risk of PD and other neuroinflammatory disorders, such as Alzheimer's disease. The goal of this study was to investigate the effects of treadmill exercise on α-synuclein-induced neuroinflammation and neuronal cell death in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD...
May 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28527784/phrenic-and-hypoglossal-nerve-activity-during-respiratory-response-to-hypoxia-in-6-ohda-unilateral-model-of-parkinson-s-disease
#19
Kryspin Andrzejewski, Krystyna Budzińska, Katarzyna Kaczyńska
AIMS: Parkinson's disease (PD) patients apart from motor dysfunctions exhibit respiratory disturbances. Their mechanism is still unknown and requires investigation. Our research was designed to examine the activity of phrenic (PHR) and hypoglossal (HG) nerves activity during a hypoxic respiratory response in the 6-hydroxydopamine (6-OHDA) model of PD. MAIN METHODS: Male adult Wistar rats were injected unilaterally with 6-OHDA (20μg) or the vehicle into the right medial forebrain bundle (MFB)...
May 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/28527712/insulin-fibrillation-the-influence-and-coordination-of-zn-2
#20
Christian Grundahl Frankær, Pernille Sønderby, Maria Blanner Bang, Ramona Valentina Mateiu, Minna Groenning, Jens Bukrinski, Pernille Harris
Protein amyloid fibrillation is obtaining much focus because it is connected with amyloid-related human diseases such as Alzheimer's disease, diabetes mellitus type 2, or Parkinson's disease. The influence of metal ions on the fibrillation process and whether it is implemented in the amyloid fibrils has been debated for some years. We have therefore investigated the influence and binding geometry of zinc in fibrillated insulin using extended X-ray absorption fine-structure and X-ray absorption near-edge structure spectroscopy...
May 17, 2017: Journal of Structural Biology
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