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Shortened cervix

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https://www.readbyqxmd.com/read/29889751/outpatient-foley-catheter-for-induction-of-labor-in-parous-women-a-randomized-controlled-trial
#1
Spencer G Kuper, Victoria C Jauk, David M George, Rodney K Edwards, Jeff M Szychowski, Sara E Mazzoni, Michelle J Wang, Pamela Files, Alan T Tita, Akila Subramaniam, Lorie M Harper
OBJECTIVE: To assess whether outpatient cervical ripening with a transcervical Foley catheter in parous women undergoing elective induction of labor shortens the total duration of time from admission to the labor ward until delivery. METHODS: We performed an open-label randomized controlled trial at a single academic center in parous women at 39 weeks of gestation or greater with a cervix 3 cm or less dilated, or, if 2-3 cm dilated, less than 80% effaced and reassuring fetal heart rate monitoring (defined as moderate variability with a normal baseline and absence of decelerations)...
June 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29712877/characterization-of-collagen-microstructural-organization-of-human-cervical-tissue
#2
Jia Hao, Wang Yao, William-Barton Ryan Harris, Joy Y Vink, Kristin Myers, Eve Donnelly
The cervix shortens and softens as its collagen microstructure remodels in preparation for birth. Altered cervical tissue collagen microstructure can contribute to a mechanically weak cervix and premature cervical dilation and delivery. To investigate the local microstructural changes associated with anatomic location and pregnancy, we used second harmonic generation microscopy to quantify the orientation and spatial distribution of collagen throughout cervical tissue from 4 pregnant and 14 non-pregnant women...
April 30, 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29663469/quantitative-ultrasound-analysis-of-proximal-and-distal-cervical-tissue-echogenicity-in-premature-cervical-remodeling
#3
Matthew J Blitz, Sleiman R Ghorayeb, Sarah L Pachtman, Megan Murphy, Zara Rahman, Lakha Prasannan, Cristina P Sison, Nidhi Vohra, Burton Rochelson
OBJECTIVES: To determine whether a novel, noninvasive quantitative ultrasound (US) technique can detect differences in proximal and distal cervical tissue echogenicity in women with and without a shortened cervical length (CL). METHODS: We conducted a retrospective case-control study of singleton pregnancies at 16 to 26 weeks' gestation in which a transvaginal US examination was performed to measure CL from 2013 to 2015. Initial CLs in cases and controls were less than 2...
April 16, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29606552/sexual-activity-recommendations-in-high-risk-pregnancies-what-is-the-evidence
#4
REVIEW
Sally E MacPhedran
BACKGROUND: While sexual activity in normal, healthy pregnant women is safe, concern regarding elements of the sexual act have led to restrictions in pregnancies experiencing complications that are frequently insufficiently addressed in clinical practice. AIM: To comprehensively review the literature for evidence that supports or refutes specific sexual activity restrictions in high-risk pregnancy conditions. METHODS: A search of PubMed, MEDLINE, Ovid, UpToDate, Google Scholar, and Google for relevant publications related to any aspect of sexual activity affecting high-risk pregnancies complicated by history of pre-term delivery, shortened cervix, presence of cerclage, pre-mature rupture of membranes, placenta abruption, placenta previa, multiple gestation, or history of classical cesarean section was performed...
March 29, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29566658/punch-biopsies-shorten-time-to-clearance-of-high-risk-human-papillomavirus-infections-of-the-uterine-cervix
#5
K U Petry, J Horn, A Luyten, R T Mikolajczyk
BACKGROUND: The primary objective was to determine human papilloma virus (HPV) clearance rate after cervical biopsy among women with persistent high-risk HPV infection compared with spontaneous HPV clearance rate in the absence of biopsy. METHODS: We collected data from a dedicated screening program of women aged 30-70 years old. Inclusion criteria for the baseline non-interventional cohort were a positive HPV test (hybrid capture 2, HC2) and normal cytology. In the baseline cohort women were followed with approximately yearly HPV-tests and cytology until HPV regressed (one negative HPV test) or interventions in the form of diagnostic biopsies or therapy...
March 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29566564/association-between-preterm-labour-and-pelvic-floor-muscle-function
#6
Turhan Aran, Ipek Pekgöz, Hasan Bozkaya, Mehmet A Osmanagaoglu
We hypothesised that the pressure on the cervix increases with advancing gestation and it may lead to a cervical shortening and cause preterm labour in women with weak pelvic floor muscles. The aim of this prospective study was to measure vaginal resting pressure and pelvic floor muscle strength in the first trimester of pregnancy and to investigate their effects on labour. A study was conducted on the pregnant women with a low risk for preterm birth. The pelvic floor muscle strength and vaginal resting pressure were assessed in 320 pregnant women at their first trimester with a vaginal pressure measurement device...
March 23, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29446813/ultrasound-monitoring-of-cervical-length-in-twin-pregnancies
#7
Kaouther Dimassi, Ines Bouriel, Amel Triki, Ali Mrabet, Mohamed Faouzi Gara
BACKGROUND: Preterm delivery is the major cause of adverse outcomes in twin pregnancy.  A shortened cervix at 20-24 weeks of amenorrhea is a good predictor of preterm birth in asymptomatic patients. However, there are no recommendations for serial cervical length measurements for these high risk pregnancies. OBJECTIVES: To evaluate the benefits from monthly cervical length monitoring in asymptomatic twin pregnancies. METHODS: This was a prospective study...
March 2017: La Tunisie Médicale
https://www.readbyqxmd.com/read/28915136/laparoscopic-mesh-less-cervicosacropexy-for-uterovaginal-prolapse
#8
Renato Seracchioli, Diego Raimondo, Alessandro Arena, Giulia Gava, Clara Parmeggiani, Valentina Martelli, Elisa Moro, Margherita Zanello, Roberto Paradisi, Mohamed Mabrouk
OBJECTIVES: This study aimed to evaluate surgical and clinical outcomes of laparoscopic mesh-less cervicosacropexy for the treatment of uterovaginal prolapse. METHODS: This single institutional review board-approved prospective cohort study enrolled 46 consecutive, sexually active symptomatic women requiring surgical correction of uterovaginal prolapse, from July 2013 to March 2016. After supracervical laparoscopic hysterectomy, the cervix was suspended to the anterior longitudinal ligament of the sacral promontory through a continuous suture with plication and shortening of the right uterosacral ligament...
September 14, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28901007/pharmacological-and-mechanical-interventions-for-labour-induction-in-outpatient-settings
#9
REVIEW
Joshua P Vogel, Alfred O Osoti, Anthony J Kelly, Stefania Livio, Jane E Norman, Zarko Alfirevic
BACKGROUND: Induction of labour is carried out for a variety of indications and using a range of methods. For women at low risk of pregnancy complications, some methods of induction of labour or cervical ripening may be suitable for use in outpatient settings. OBJECTIVES: To examine pharmacological and mechanical interventions to induce labour or ripen the cervix in outpatient settings in terms of effectiveness, maternal satisfaction, healthcare costs and, where information is available, safety...
September 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28861041/programmed-fetal-membrane-senescence-and-exosome-mediated-signaling-a-mechanism-associated-with-timing-of-human-parturition
#10
REVIEW
Ramkumar Menon, Sam Mesiano, Robert N Taylor
Human parturition is an inflammatory process that involves both fetal and maternal compartments. The precise immune cell interactions have not been well delineated in human uterine tissues during parturition, but insights into human labor initiation have been informed by studies in animal models. Unfortunately, the timing of parturition relative to fetal maturation varies among viviparous species-indicative of different phylogenetic clocks and alarms-but what is clear is that important common pathways must converge to control the birth process...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28778109/reference-ranges-for-ultrasonographic-measurements-of-the-uterine-cervix-in-low-risk-pregnant-women
#11
Kleber Cursino Andrade, Thaísa Guedes Bortoletto, Cristiane Martins Almeida, Renan Antonio Daniel, Heloísa Avo, Rodolfo Carvalho Pacagnella, José Guilherme Cecatti
Objective To define transvaginal ultrasound reference ranges for uterine cervix measurements according to gestational age (GA) in low-risk pregnancies. Methods Cohort of low-risk pregnant women undergoing transvaginal ultrasound exams every 4 weeks, comprising measurements of the cervical length and volume, the transverse and anteroposterior diameters of the cervix, and distance from the entrance of the uterine artery into the cervix until the internal os. The inter- and intraobserver variabilities were assessed with the linear correlation coefficient and the Student t-test...
September 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28729911/vaginal-progesterone-to-reduce-preterm-birth-among-hiv-infected-pregnant-women-in-zambia-a-feasibility-study-protocol
#12
Joan T Price, Katie R Mollan, Nurain M Fuseini, Bethany L Freeman, Helen B Mulenga, Amanda H Corbett, Bellington Vwalika, Jeffrey S A Stringer
BACKGROUND: Women infected with HIV have a risk of preterm birth (PTB) that is twice that among uninfected women, and treatment with antiretroviral therapy (ART) may further increase this risk. Progesterone supplementation reduces the risk of preterm delivery in women who have a shortened cervix in the midtrimester. We propose to study the feasibility of a trial of vaginal progesterone (VP) to prevent PTB among HIV-infected women receiving ART in pregnancy. Given low adherence among women self-administering vaginal study product in recent microbicide trials, we plan to investigate whether adequate adherence to VP can be achieved prior to launching a full-scale efficacy trial...
2018: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/28673792/cervical-cerclage-placement-decreases-local-levels-of-proinflammatory-cytokines-in-patients-with-cervical-insufficiency
#13
Stephany P Monsanto, Silvia Daher, Erika Ono, Karen Priscilla Tezotto Pendeloski, Évelyn Trainá, Rosiane Mattar, Chandrakant Tayade
BACKGROUND: Cervical insufficiency is characterized by premature, progressive dilation and shortening of the cervix during pregnancy. If left unattended, this can lead to the prolapse and rupture of the amniotic membrane, which usually results in midtrimester pregnancy loss or preterm birth. Previous studies have shown that proinflammatory cytokines such as interleukin-1β, interleukin-6, interleukin-8, and tumor necrosis factor alpha are up-regulated in normal parturition but are also associated with preterm birth...
October 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28651447/the-association-between-fetal-fibronectin-and-spontaneous-preterm-birth-in-twin-pregnancies-with-a-shortened-cervical-length
#14
Kathy C Matthews, Simi Gupta, Jennifer Lam-Rachlin, Daniel H Saltzman, Andrei Rebarber, Nathan S Fox
OBJECTIVE: To estimate the association between a positive fetal fibronectin (fFN) and spontaneous preterm birth (SPTB) in twin pregnancies with a shortened cervical length (CL). STUDY DESIGN: Retrospective cohort study of asymptomatic twin pregnancies managed by a single MFM practice from 2005 to 2016. We included all women with a shortened CL ≤25 mm at 22-28 weeks, and compared outcomes between women with a positive and negative fFN result. RESULTS: One hundred fifty-five patients were included, 129 (83...
July 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28585708/the-cytokine-network-in-women-with-an-asymptomatic-short-cervix-and-the-risk-of-preterm-delivery
#15
Adi L Tarca, Wendy Fitzgerald, Piya Chaemsaithong, Zhonghui Xu, Sonia S Hassan, Jean-Charles Grivel, Nardhy Gomez-Lopez, Bogdan Panaitescu, Percy Pacora, Eli Maymon, Offer Erez, Leonid Margolis, Roberto Romero
PROBLEM: To characterize the amniotic fluid (AF) inflammatory-related protein (IRP) network in patients with a sonographic short cervix (SCx) and to determine its relation to early preterm delivery (ePTD). METHOD OF STUDY: A retrospective cohort study included women with a SCx (≤25 mm; n=223) who had amniocentesis and were classified according to gestational age (GA) at diagnosis and delivery (ePTD <32 weeks of gestation). RESULTS: (i) In women with a SCx ≤ 22 1/7 weeks, the concentration of most IRPs increased as the cervix shortened; those with ePTD had a higher rate of increase in MIP-1α, MCP-1, and IL-6 concentrations than those delivering later; and (ii) the concentration of most IRPs and the correlation between several IRP pairs were higher in the ePTD group than for those delivering later...
September 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28570639/cerclage-position-cervical-length-and-preterm-delivery-in-women-undergoing-ultrasound-indicated-cervical-cerclage-a-retrospective-cohort-study
#16
Joanna R Cook, Susan Chatfield, Manju Chandiramani, Lindsay Kindinger, Stefano Cacciatore, Lynne Sykes, Tiong Teoh, Andrew Shennan, Vasso Terzidou, Phillip R Bennett
OBJECTIVE: The objectives were to assess whether anatomical location of ultrasound (USS) indicated cervical cerclage and/or the degree of cervical shortening (cervical length; CL) prior to and following cerclage affects the risk of preterm birth (PTB). METHOD: A retrospective cohort study of 179 women receiving cerclage for short cervix (≤25mm) was performed. Demographic data, CL before and after cerclage insertion, height of cerclage (distance from external os) and gestation at delivery were collected...
2017: PloS One
https://www.readbyqxmd.com/read/28535404/placental-inflammation-and-its-relationship-to-cervicovaginal-fetal-fibronectin-in-preterm-birth
#17
Laura van der Krogt, Alexandra E Ridout, Paul T Seed, Andrew H Shennan
OBJECTIVE: Late miscarriage and preterm birth are frequently thought to be associated with inflammation and infection, although in most cases the underlying cause of early delivery remains unknown. The placenta is the organ that links mother and fetus during pregnancy, and postnatal examination may provide useful information about pathophysiology. The relationship between placental pathological lesions and predictive markers of early delivery has not been explored. We sought to characterize preterm deliveries according to placental pathology and relate these to the performance of reliable predictive markers, fetal fibronectin and cervical length...
July 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28481445/optimising-fertility-outcomes-for-women-with-early-stage-cervical-cancer-when-less-is-more
#18
E Tingi, E J Crosbie, G Owens
No abstract text is available yet for this article.
October 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28475099/vaginal-examination-vs-cervical-length-which-is-superior-in-predicting-preterm-birth
#19
Merav Sharvit, Reut Weiss, Yael Ganor Paz, Keren Tzadikevitch Geffen, Netanella Danielli Miller, Tal Biron-Shental
OBJECTIVE: To compare the predictive value of preterm birth (PTB) by transvaginal sonographic cervical length (CL) measurement to digital examination of the cervix (Bishop score - BS), in patients with premature contractions (PC) and intact membranes. DESIGN: A retrospective case-control study. SETTING: Meir Medical Center, Kfar Saba, Israel. POPULATION: Women at 24-34 weeks of gestation who were hospitalized with PC and intact membranes...
November 27, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28409530/digital-stretching-of-cervix-in-the-active-phase-of-labour-to-shorten-its-duration-a-randomised-control-trial
#20
RANDOMIZED CONTROLLED TRIAL
Deepti Pinto Rosario, Anuja Abraham, Swati Rathore, Santosh Joseph Benjamin, Visalakshi Jeyaseelan, Jiji Elizabeth Mathews
An assessment of the efficacy and satisfaction of women in active labour having digital cervical stretching compared to women who did not have this intervention. Ours was a randomised controlled trial at a tertiary centre in India. Low-risk women at term with vertex presentation in active labour with ruptured membranes and cervical dilation of 4-6 cm were included. Stretching to delivery interval was 247.5 ± 158.2 min in the intervention group and 265.5 ± 158.4 in the control group. The mode of delivery, incidence of cervical tear, and maternal, fetal and neonatal complications were similar in both groups...
October 2017: Tropical Doctor
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