Jeroen T Buijs, Robin van Beijnum, Rayna J S Anijs, El Houari Laghmani, Lily Sensuk, Cas Minderhoud, Betül Ünlü, Frederikus A Klok, Peter J K Kuppen, Suzanne C Cannegieter, Henri H Versteeg
Novel biomarkers are needed to improve current imperfect risk prediction models for cancer-associated thrombosis (CAT). We recently identified an RNA-sequencing profile that associates with CAT in colorectal cancer (CRC) patients, with REG4, SPINK4, and SERPINA1 as the top-3 upregulated genes at mRNA level. In the current study, we investigated whether protein expression of REG4, SPINK4 and alpha-1 antitrypsin (A1AT, encoded by SERPINA1) in the tumor associated with CAT in an independent cohort of CRC patients...
December 8, 2023: Journal of Thrombosis and Thrombolysis