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Zuqiang Liu, Kaizhou Jin, Meng Guo, Jiang Long, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Guopei Luo, Xianjun Yu
BACKGROUND: The C-reactive protein/albumin (CRP/Alb) ratio is associated with outcome in septic patients. However, as an inflammation-based score, its prognostic value for cancer has scarcely been investigated. METHODS: Between February 2010 and January 2015, we enrolled 386 patients with pancreatic ductal adenocarcinoma. Univariate and multivariate survival analysis between the groups were evaluated. Receiver operating characteristics curves were generated and areas under the curve (AUC) were compared to evaluate the discriminatory ability of the inflammation-based prognostic scoring systems, including CRP/Alb ratio, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and modified Glasgow prognostic score (mGPS)...
September 20, 2016: Annals of Surgical Oncology
Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Shuji Yonehara, Tsuyoshi Kobayashi, Toshikatsu Fukuda, Masahiro Nakahara, Yoshinori Kuroda, Toshio Noriyuki
BACKGROUND/AIM: Gallbladder carcinoma (GBCA) has extremely poor outcomes. We aimed to investigate clinicopathological prognostic variables, including the modified Glasgow prognostic score (mGPS), for patients with resected GBCA. PATIENTS AND METHODS: This retrospective study included 54 patients with GBCA resected between 1996 and 2014. Univariate and multivariate analyses were performed to identify prognostic factors associated with overall and recurrence-free survival...
September 2016: Anticancer Research
Alexander Kaltenborn, Harald Schrem, Benedikt Reichert, Felix Braun, Nikos Emmanouilidis, Jürgen Klempnauer, Thomas Becker, Nils Heits
AIM: This study aimed to evaluate whether the Glasgow Prognostic Score (GPS) and its variants are able to predict mortality in live donor and deceased donor liver transplantation for hepatocellular carcinoma. METHODS: Data of 29 live donor and 319 deceased donor transplantations from two German transplant centers was analyzed. The GPS, modified GPS, hepatic GPS, and Abe score were investigated. Receiver operating characteristic (ROC) curve analysis was carried out to calculate the sensitivity, specificity, and overall model correctness of the investigated scores as a predictive model...
September 6, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Lizhen Zhu, Xiaofen Li, Yanwei Shen, Ying Cao, Xuefeng Fang, Jiaqi Chen, Ying Yuan
PURPOSE: Pretreatment systemic inflammatory response has been confirmed to have prognostic value in patients with inoperable non-small-cell lung cancer (NSCLC). Increasing studies show that the modified Glasgow prognostic score (mGPS), a prognostic score based on C-reactive protein (CRP) and albumin, is a prognostic factor in these patients. This study was aimed at recognizing possible prognostic factors and new prognostic scores of inoperable NSCLC based on pretreatment systemic inflammatory response...
2016: OncoTargets and Therapy
Rui Tian, Fei Zhang, Peng Sun, Jing Wu, Hong Yan, Ai-Ran Wu, Min Zhang, Yu-Lu Jiang, Yan-Hong Lu, Qiu-Yan Xu, Xiao-Hong Zhan, Rong-Xin Zhang, Li-Ting Qian, Jie He
The present study was designed to investigate the prognostic significance of the preoperative sensitive-modified Glasgow prognostic score (S-mGPS) and its superiority in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative albumin and C-reactive protein (CRP) levels were retrospectively collected in 442 patients who underwent transthoracic esophagectomy. The S-mGPS was calculated before surgery based on optimal cutoff values of 45.6 g/L for albumin and 10.0 mg/L for CRP...
August 12, 2016: Oncotarget
Rui Tian, Hong Yan, Fei Zhang, Peng Sun, Ai-Ran Wu, Min Zhang, Yu-Lu Jiang, Jing Wu, Yan-Hong Lu, Qiu-Yan Xu, Xiao-Hong Zhan, Rong-Xin Zhang, Li-Ting Qian, Jie He
The present study was to establish a prognostic indicator based on preoperative fibrinogen and C-reactive protein (CRP) (FC score) in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative plasma fibrinogen and serum CRP levels were reviewed in patients who underwent transthoracic esophagectomy. The optimal cut-off value for fibrinogen and CRP was defined as 4.0 g/dL and 10.0 mg/L according to previous reports. Patients with elevated fibrinogen and CRP levels were assigned a score of 2, those with only one of these two abnormalities were allocated a score of 1, and those with neither of the two abnormalities were assigned a score of 0...
August 9, 2016: Oncotarget
Masataka Okuno, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: Inflammation-based prognostic scores are useful prognostic indicators for several types of cancer. The aim of this study was to evaluate whether the scores predict survival impact in unresectable perihilar cholangiocarcinoma. METHODS: The modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio, and Prognostic Nutritional Index, were retrospectively assessed in 219 patients with unresectable perihilar cholangiocarcinoma...
October 2016: Journal of Hepato-biliary-pancreatic Sciences
Yuan Zhang, Guan-Qun Zhou, Xu Liu, Lei Chen, Wen-Fei Li, Ling-Long Tang, Qing Liu, Ying Sun, Jun Ma
BACKGROUND: The prognostic value of C-reactive protein/albumin ratio (CRP/Alb), a novel inflammation-based marker, remains unknown in nasopharyngeal carcinoma (NPC). METHODS: We conducted a retrospective review of 1572 consecutive patients with non-metastatic NPC. Patients were randomly divided into a training set (n = 514) and validation set (n = 1058). The prognostic value of the CRP/Alb ratio and the modified Glasgow prognostic score (mGPS; a well-recognized inflammation-based score) was assessed...
2016: Journal of Cancer
Jun Osugi, Satoshi Muto, Yuki Matsumura, Mitsunori Higuchi, Hiroyuki Suzuki, Mitsukazu Gotoh
OBJECTIVE: The present study compared the prognostic value of the Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS (HS-mGPS), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), prognostic index (PI), and prognostic nutritional index (PNI) in patients with resectable non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: This retrospective study included 327 consecutive patients with resectable NSCLC with a follow.-up period...
April 2016: Journal of Cancer Research and Therapeutics
Barry J A Laird, Marie Fallon, Marianne J Hjermstad, Sharon Tuck, Stein Kaasa, Pål Klepstad, Donald C McMillan
PURPOSE: Quality of life is a key component of cancer care; however, the factors that determine quality of life are not well understood. The aim of this study was to examine the relationship between quality of life parameters, performance status (PS), and the systemic inflammatory response in patients with advanced cancer. METHODS: An international biobank of patients with advanced cancer was analyzed. Quality of life was assessed at a single time point by using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C-30 (EORTC QLQ-C30)...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
Mengwan Wu, Jing Guo, Lihong Guo, Qiang Zuo
Recent studies have demonstrated the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in cancer. However, the role of the CRP/Alb ratio in advanced pancreatic cancer (PC) has not been examined. A retrospective study of 233 patients with advanced PC was conducted. We investigated the relationship between the CRP/Alb ratio, clinicopathological variables, and overall survival (OS). The optimal cutoff point of the CRP/Alb ratio was 0.54. A higher CRP/Alb ratio was significantly associated with an elevated neutrophil-lymphocyte ratio (NLR) (P < 0...
June 25, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Takashi Matsuzuka, Masahiro Suzuki, Satoshi Saijoh, Masakazu Ikeda, Mitsumasa Imaizumi, Yukio Nomoto, Takamichi Matsui, Yasuhiro Tada, Koichi Omori
We retrospectively analyzed 54 patients who died of head and neck squamous cell caricinoma regarding the process and duration of cachexia using the modified Glasgow Prognostic Score (mGPS). The patients were classified as having cachexia when the serum albumin level was less than 3.5 mg/dL and the C-reactive protein (CRP) level was more than 0.5 mg/dL. The number of patients with cachexia was eight (8%) at the first visit and 50 (93%) at the time of death. In the 50 patients, the median and average time of having cachexia was 59 and 95 days, respectively...
February 2016: Nihon Jibiinkoka Gakkai Kaiho
Suguru Yamada, Tsutomu Fujii, Norimitsu Yabusaki, Kenta Murotani, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
A variety of systemic inflammation-based prognostic scores have been explored; however, there has been no study to clarify which score could best reflect survival in resected pancreatic cancer patients.Between 2002 and 2014, 379 consecutive patients who underwent curative resection of pancreatic cancer were enrolled. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), and prognostic nutritional index (PNI) scores for each patient were calculated...
May 2016: Medicine (Baltimore)
Meng-Che Hsieh, Shih-Hor Wang, Seng-Kee Chuah, Yu-Hung Lin, Jui Lan, Kun-Ming Rau
The outcomes of patients with metastatic gastric cancer (mGC) are poor. Recent studies have identified the prognostic impact of inflammatory response and nutritional status on survival for patients with gastric cancer. This study aims to create a prognostic model using inflammatory- and nutrition-based scores to predict survival in patients with mGC treated with chemotherapy.After institutional review board approval, patients who had mGC and were treated with chemotherapy from 2007 to 2012 at Kaohsiung Chang Gung Memorial Hospital were retrospectively reviewed...
April 2016: Medicine (Baltimore)
Asta Bye, Nima Wesseltoft-Rao, Per Ole Iversen, Grete Skjegstad, Kirsten B Holven, Stine Ulven, Marianne J Hjermstad
Chronic systemic inflammatory response is proposed as an underlying mechanism for development of cancer cachexia. We conducted a prospective study to examine changes in inflammatory biomarkers during the disease course and the relationship between inflammatory biomarkers and cachexia in patients with inoperable pancreatic cancer. Twenty patients, median (range) age 67.5 (35-79) years, 5 females, were followed for median 5.5 (1-12) months. Cachexia was diagnosed according to the 2011 consensus-based classification system (weight loss >5 % past six months, BMI < 20 kg/m(2) and weight loss >2 %, or sarcopenia) and the modified Glasgow Prognostic score (mGPS) that combines CRP and albumin levels...
June 2016: Medical Oncology
Joseph C Y Chan, David L Chan, Connie I Diakos, Alexander Engel, Nick Pavlakis, Anthony Gill, Stephen J Clarke
OBJECTIVE: The study aims to investigate the prognostic value of the lymphocyte-to-monocyte ratio (LMR) in patients with colorectal cancer (CRC) undergoing curative resection and to compare it to established biomarkers including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS), and combined BRAF-mismatch repair (MMR) status. BACKGROUND: The prognostic significance of systemic inflammatory markers in CRC such as the NLR, PLR, and mGPS has been well defined...
April 8, 2016: Annals of Surgery
Wataru Saburi
Carbohydrate isomerases/epimerases are essential in carbohydrate metabolism, and have great potential in industrial carbohydrate conversion. Cellobiose 2-epimerase (CE) reversibly epimerizes the reducing end d-glucose residue of β-(1→4)-linked disaccharides to d-mannose residue. CE shares catalytic machinery with monosaccharide isomerases and epimerases having an (α/α)6-barrel catalytic domain. Two histidine residues act as general acid and base catalysts in the proton abstraction and addition mechanism...
July 2016: Bioscience, Biotechnology, and Biochemistry
Hiroki Ishihara, Tsunenori Kondo, Kenji Omae, Toshio Takagi, Jumpei Iizuka, Hirohito Kobayashi, Kazunari Tanabe
BACKGROUND: Cancer cachexia is associated with patient outcomes. OBJECTIVE: The objective was to evaluate the effect of cachexia on survival among patients with metastatic renal cell carcinoma (mRCC) who had received first-line sunitinib treatment. PATIENTS AND METHODS: Seventy-one patients were retrospectively evaluated. Sarcopenia was diagnosed using sex-specific cut-offs for skeletal muscle index (measured using pre-treatment computed tomography) that were adjusted for body mass index...
March 29, 2016: Targeted Oncology
J Gorham, L Ameye, M Paesmans, T Berghmans, J P Sculier, A-P Meert
INTRODUCTION: In a first study, we found predictive factors for hospital admission in lung cancer patients consulting at the emergency department. Knowing that systemic inflammation is a prognostic factor in cancer patients, the goal of our study was to determine whether systemic inflammation measured using the modified Glasgow prognostic score can improve the predictive value of our previous model. METHODS: We conducted a retrospective study including all patients with lung cancer consulting at the emergency department of an oncology hospital between January 1st 2008 and December 31st 2010...
March 23, 2016: Revue des Maladies Respiratoires
Siun M Walsh, Sarah Casey, Raymond Kennedy, Narayanasamy Ravi, John V Reynolds
BACKGROUND: The modified Glasgow Prognostic Score (mGPS), which combines indices of decreased plasma albumin and elevated CRP, has reported independent prognostic significance in colorectal cancer, but its value in upper gastrointestinal cancer is unclear. The aim of this study was to assess the prognostic significance of mGPS in patients with operable esophageal malignancy. METHODS: Patients undergoing resection with curative intent between January 2008 and June 2013 were included...
June 2016: Journal of Surgical Oncology
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