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https://www.readbyqxmd.com/read/27894101/impact-of-hematological-inflammatory-markers-on-clinical-outcome-in-patients-with-salivary-duct-carcinoma-a-multi-institutional-study-in-japan
#1
Daisuke Kawakita, Yuichiro Tada, Yorihisa Imanishi, Shintaro Beppu, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Akira Shimizu, Yukiko Sato, Chihiro Fushimi, Soichiro Takase, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Tomotaka Shimura, Toyoyuki Hanazawa, Shingo Murakami, Toshitaka Nagao
The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27873100/the-pretreatment-systemic-inflammatory-response-is-an-important-determinant-of-poor-pathologic-response-for-patients-undergoing-neoadjuvant-therapy-for-rectal-cancer
#2
Stephan B Dreyer, Arfon G M T Powell, Stephen T McSorley, Ashita Waterston, James J Going, Joanne Edwards, Donald C McMillan, Paul G Horgan
BACKGROUND: Not all patients respond equally to neoadjuvant chemoradiotherapy (nCRT), with subsequent effects on survival. The systemic inflammatory response has been shown to predict long-term outcomes in colorectal cancer. The current study examined the association between systemic inflammation and nCRT in patients with rectal cancer. METHODS: Between 1999 and 2010, patients who underwent nCRT were identified. Serum measurements of hemoglobin, C-reactive protein, albumin, modified Glasgow prognostic score (mGPS), and differential white cell counts were obtained before and after nCRT...
November 21, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27866811/the-modified-glasgow-prognosis-score-predicts-for-overall-and-disease-free-survival-following-cytoreductive-surgery-and-hipec-in-patients-with-pseudomyxoma-peritonei-of-appendiceal-origin
#3
G H C Tan, C A Novo, S Dayal, K Chandrakumaran, F Mohamed, T Cecil, B J Moran
BACKGROUND: The modified Glasgow prognostic score (incorporating C-reactive protein and albumin) predicts survival in patients with gastro-intestinal tract cancer but has not been evaluated in patients with peritoneal malignancy. The aim was to evaluate the modified Glasgow score preoperatively in patients undergoing complete cytoreductive surgery (CCRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP) of appendiceal origin. METHODS: Prospectively collected data from patients with PMP of appendiceal origin following CCRS and HIPEC between January 2007 and December 2011 were analysed...
October 31, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27854304/a-novel-inflammation-based-stage-i-stage-predicts-overall-survival-of-patients-with-nasopharyngeal-carcinoma
#4
Jian-Pei Li, Shu-Lin Chen, Xiao-Min Liu, Xia He, Shan Xing, Yi-Jun Liu, Yue-Hao Lin, Wan-Li Liu
Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified GPS (mGPS) and C-reactive protein/Albumin (CRP/Alb) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC). In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted...
November 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27847731/c-reactive-protein-albumin-ratio-as-prognostic-score-in-oral-squamous-cell-carcinoma
#5
Heung-Chul Park, Moon-Young Kim, Chul-Hwan Kim
OBJECTIVES: Many studies have examined histopathological factors and various prognostic scores related to inflammation to predict outcomes. Here, we examined the prognostic value of the C-reactive protein/albumin (CRP/alb) ratio in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: This retrospective study included 40 patients with OSCC. Using univariate and multivariate analyses, we focused on the correlation of the CRP/alb ratio with clinicopathological characteristics and with overall survival...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27798927/inflammation-based-prognostic-score-in-patients-with-living-donor-liver-transplantation-for-hepatocellular-carcinoma
#6
Norifumi Harimoto, Tomoharu Yoshizumi, Tomonari Shimagaki, Akihisa Nagatsu, Takashi Motomura, Noboru Harada, Hirohisa Okabe, Shinji Itoh, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. PATIENTS AND METHODS: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27760948/-significance-of-perioperative-neutrophil-lymphocyte-ratio-nlr-in-gastric-cancer-and-colon-cancer
#7
Masano Sagawa, Hirokazu Yagawa, Souichi Konno, Atsuko Usuda, Hiroyuki Maeda, Kanu Kim, Toshifumi Watanabe, Emiko Yamaya, Takebumi Usui, Hajime Yokomizo, Kazuhiko Yoshimatsu, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
BACKGROUND: We examined the significance of neutrophil lymphocyte ratio(NLR)in gastric cancer and colon cancer in the perioperative period. METHOD: There were 46 patients(21 with gastric cancer and 25 with colon cancer). We examined the association between preoperative NLR and other indicators of nutritional status, as well as the relationship between preoperative NLR and the incidence of postoperative complications(all complications/infectious complications). RESULT: NLR was higher in those with zinc<65 mg, prognostic nutritional index(PNI)≤40, and modified Glasgow prognostic score(mGPS)of 2 (p<0...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27650825/prognostic-value-of-the-crp-alb-ratio-a-novel-inflammation-based-score-in-pancreatic-cancer
#8
Zuqiang Liu, Kaizhou Jin, Meng Guo, Jiang Long, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Guopei Luo, Xianjun Yu
BACKGROUND: The C-reactive protein/albumin (CRP/Alb) ratio is associated with outcome in septic patients. However, as an inflammation-based score, its prognostic value for cancer has scarcely been investigated. METHODS: Between February 2010 and January 2015, we enrolled 386 patients with pancreatic ductal adenocarcinoma. Univariate and multivariate survival analysis between the groups were evaluated. Receiver operating characteristics curves were generated and areas under the curve (AUC) were compared to evaluate the discriminatory ability of the inflammation-based prognostic scoring systems, including CRP/Alb ratio, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and modified Glasgow prognostic score (mGPS)...
September 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27630345/preoperative-systemic-inflammation-and-complications-affect-long-term-gallbladder-carcinoma-outcomes-following-surgery-with-curative-intent
#9
Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Shuji Yonehara, Tsuyoshi Kobayashi, Toshikatsu Fukuda, Masahiro Nakahara, Yoshinori Kuroda, Toshio Noriyuki
BACKGROUND/AIM: Gallbladder carcinoma (GBCA) has extremely poor outcomes. We aimed to investigate clinicopathological prognostic variables, including the modified Glasgow prognostic score (mGPS), for patients with resected GBCA. PATIENTS AND METHODS: This retrospective study included 54 patients with GBCA resected between 1996 and 2014. Univariate and multivariate analyses were performed to identify prognostic factors associated with overall and recurrence-free survival...
September 2016: Anticancer Research
https://www.readbyqxmd.com/read/27598002/the-glasgow-prognostic-score-and-its-variants-predict-mortality-in-living-donor-but-not-in-deceased-donor-liver-transplantation-for-hepatocellular-carcinoma-a-double-center-validation-study
#10
Alexander Kaltenborn, Harald Schrem, Benedikt Reichert, Felix Braun, Nikos Emmanouilidis, Jürgen Klempnauer, Thomas Becker, Nils Heits
AIM: This study aimed to evaluate whether the Glasgow Prognostic Score (GPS) and its variants are able to predict mortality in live donor and deceased donor liver transplantation for hepatocellular carcinoma. METHODS: Data of 29 live donor and 319 deceased donor transplantations from two German transplant centers was analyzed. The GPS, modified GPS, hepatic GPS, and Abe score were investigated. Receiver operating characteristic (ROC) curve analysis was carried out to calculate the sensitivity, specificity, and overall model correctness of the investigated scores as a predictive model...
September 6, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/27540301/a-new-prognostic-score-based-on-the-systemic-inflammatory-response-in-patients-with-inoperable-non-small-cell-lung-cancer
#11
Lizhen Zhu, Xiaofen Li, Yanwei Shen, Ying Cao, Xuefeng Fang, Jiaqi Chen, Ying Yuan
PURPOSE: Pretreatment systemic inflammatory response has been confirmed to have prognostic value in patients with inoperable non-small-cell lung cancer (NSCLC). Increasing studies show that the modified Glasgow prognostic score (mGPS), a prognostic score based on C-reactive protein (CRP) and albumin, is a prognostic factor in these patients. This study was aimed at recognizing possible prognostic factors and new prognostic scores of inoperable NSCLC based on pretreatment systemic inflammatory response...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27528228/the-preoperative-sensitive-modified-glasgow-prognostic-score-is-superior-to-the-modified-glasgow-prognostic-score-in-predicting-long-term-survival-for-esophageal-squamous-cell-carcinoma
#12
Rui Tian, Fei Zhang, Peng Sun, Jing Wu, Hong Yan, Ai-Ran Wu, Min Zhang, Yu-Lu Jiang, Yan-Hong Lu, Qiu-Yan Xu, Xiao-Hong Zhan, Rong-Xin Zhang, Li-Ting Qian, Jie He
The present study was designed to investigate the prognostic significance of the preoperative sensitive-modified Glasgow prognostic score (S-mGPS) and its superiority in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative albumin and C-reactive protein (CRP) levels were retrospectively collected in 442 patients who underwent transthoracic esophagectomy. The S-mGPS was calculated before surgery based on optimal cutoff values of 45.6 g/L for albumin and 10.0 mg/L for CRP...
August 12, 2016: Oncotarget
https://www.readbyqxmd.com/read/27517497/cumulative-score-based-on-preoperative-plasma-fibrinogen-and-serum-c-reactive-protein-could-predict-long-term-survival-for-esophageal-squamous-cell-carcinoma
#13
Rui Tian, Hong Yan, Fei Zhang, Peng Sun, Ai-Ran Wu, Min Zhang, Yu-Lu Jiang, Jing Wu, Yan-Hong Lu, Qiu-Yan Xu, Xiao-Hong Zhan, Rong-Xin Zhang, Li-Ting Qian, Jie He
The present study was to establish a prognostic indicator based on preoperative fibrinogen and C-reactive protein (CRP) (FC score) in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative plasma fibrinogen and serum CRP levels were reviewed in patients who underwent transthoracic esophagectomy. The optimal cut-off value for fibrinogen and CRP was defined as 4.0 g/dL and 10.0 mg/L according to previous reports. Patients with elevated fibrinogen and CRP levels were assigned a score of 2, those with only one of these two abnormalities were allocated a score of 1, and those with neither of the two abnormalities were assigned a score of 0...
August 9, 2016: Oncotarget
https://www.readbyqxmd.com/read/27474781/appraisal-of-inflammation-based-prognostic-scores-in-patients-with-unresectable-perihilar-cholangiocarcinoma
#14
Masataka Okuno, Tomoki Ebata, Yukihiro Yokoyama, Tsuyoshi Igami, Gen Sugawara, Takashi Mizuno, Junpei Yamaguchi, Masato Nagino
BACKGROUND: Inflammation-based prognostic scores are useful prognostic indicators for several types of cancer. The aim of this study was to evaluate whether the scores predict survival impact in unresectable perihilar cholangiocarcinoma. METHODS: The modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio, and Prognostic Nutritional Index, were retrospectively assessed in 219 patients with unresectable perihilar cholangiocarcinoma...
October 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27471556/exploration-and-validation-of-c-reactive-protein-albumin-ratio-as-a-novel-inflammation-based-prognostic-marker-in-nasopharyngeal-carcinoma
#15
Yuan Zhang, Guan-Qun Zhou, Xu Liu, Lei Chen, Wen-Fei Li, Ling-Long Tang, Qing Liu, Ying Sun, Jun Ma
BACKGROUND: The prognostic value of C-reactive protein/albumin ratio (CRP/Alb), a novel inflammation-based marker, remains unknown in nasopharyngeal carcinoma (NPC). METHODS: We conducted a retrospective review of 1572 consecutive patients with non-metastatic NPC. Patients were randomly divided into a training set (n = 514) and validation set (n = 1058). The prognostic value of the CRP/Alb ratio and the modified Glasgow prognostic score (mGPS; a well-recognized inflammation-based score) was assessed...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27461679/prognostic-impact-of-the-high-sensitivity-modified-glasgow-prognostic-score-in-patients-with-resectable-non-small-cell-lung-cancer
#16
Jun Osugi, Satoshi Muto, Yuki Matsumura, Mitsunori Higuchi, Hiroyuki Suzuki, Mitsukazu Gotoh
OBJECTIVE: The present study compared the prognostic value of the Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS (HS-mGPS), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), prognostic index (PI), and prognostic nutritional index (PNI) in patients with resectable non-small cell lung cancer (NSCLC). MATERIALS AND METHODS: This retrospective study included 327 consecutive patients with resectable NSCLC with a follow.-up period...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27354484/quality-of-life-in-patients-with-advanced-cancer-differential-association-with-performance-status-and-systemic-inflammatory-response
#17
Barry J A Laird, Marie Fallon, Marianne J Hjermstad, Sharon Tuck, Stein Kaasa, Pål Klepstad, Donald C McMillan
PURPOSE: Quality of life is a key component of cancer care; however, the factors that determine quality of life are not well understood. The aim of this study was to examine the relationship between quality of life parameters, performance status (PS), and the systemic inflammatory response in patients with advanced cancer. METHODS: An international biobank of patients with advanced cancer was analyzed. Quality of life was assessed at a single time point by using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C-30 (EORTC QLQ-C30)...
August 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27344157/the-c-reactive-protein-albumin-ratio-predicts-overall-survival-of-patients-with-advanced-pancreatic-cancer
#18
Mengwan Wu, Jing Guo, Lihong Guo, Qiang Zuo
Recent studies have demonstrated the prognostic value of the C-reactive protein/albumin (CRP/Alb) ratio in cancer. However, the role of the CRP/Alb ratio in advanced pancreatic cancer (PC) has not been examined. A retrospective study of 233 patients with advanced PC was conducted. We investigated the relationship between the CRP/Alb ratio, clinicopathological variables, and overall survival (OS). The optimal cutoff point of the CRP/Alb ratio was 0.54. A higher CRP/Alb ratio was significantly associated with an elevated neutrophil-lymphocyte ratio (NLR) (P < 0...
June 25, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27149710/-assessment-of-cachexia-in-head-and-neck-cancer-patients-based-on-a-modified-glasgow-prognostic-score
#19
Takashi Matsuzuka, Masahiro Suzuki, Satoshi Saijoh, Masakazu Ikeda, Mitsumasa Imaizumi, Yukio Nomoto, Takamichi Matsui, Yasuhiro Tada, Koichi Omori
We retrospectively analyzed 54 patients who died of head and neck squamous cell caricinoma regarding the process and duration of cachexia using the modified Glasgow Prognostic Score (mGPS). The patients were classified as having cachexia when the serum albumin level was less than 3.5 mg/dL and the C-reactive protein (CRP) level was more than 0.5 mg/dL. The number of patients with cachexia was eight (8%) at the first visit and 50 (93%) at the time of death. In the 50 patients, the median and average time of having cachexia was 59 and 95 days, respectively...
February 2016: Nihon Jibiinkoka Gakkai Kaiho
https://www.readbyqxmd.com/read/27149487/clinical-implication-of-inflammation-based-prognostic-score-in-pancreatic-cancer-glasgow-prognostic-score-is-the-most-reliable-parameter
#20
Suguru Yamada, Tsutomu Fujii, Norimitsu Yabusaki, Kenta Murotani, Naoki Iwata, Mitsuro Kanda, Chie Tanaka, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera
A variety of systemic inflammation-based prognostic scores have been explored; however, there has been no study to clarify which score could best reflect survival in resected pancreatic cancer patients.Between 2002 and 2014, 379 consecutive patients who underwent curative resection of pancreatic cancer were enrolled. The Glasgow Prognostic Score (GPS), modified GPS (mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), and prognostic nutritional index (PNI) scores for each patient were calculated...
May 2016: Medicine (Baltimore)
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