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https://www.readbyqxmd.com/read/29761518/the-value-of-inflammation-based-prognostic-scores-in-patients-undergoing-surgical-resection-for-oesophageal-and-gastric-carcinoma
#1
Jiaxin Wen, Matthew Bedford, Ruksana Begum, Harriet Mitchell, James Hodson, John Whiting, Ewen Griffiths
BACKGROUND AND OBJECTIVES: Surgical interventions for oesophagogastric cancer carry a significant burden of morbidity and mortality. A range of inflammation based prognostic scores have been proposed in an attempt to predict outcome. This study evaluated five such prognostic scores in oesophageal and gastric carcinoma patients. METHODS: The modified Glasgow Prognostic Score (mGPS), Neutrophil Lymphocyte Ratio (NLR), Platelet Lymphocyte Ratio (PLR), Prognostic Index (PI), and Prognostic Nutrition Index (PNI) were calculated for 723 consecutive patients undergoing oesophagectomy or gastrectomy at a single center...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29742685/the-plasma-levels-of-12-cytokines-and-growth-factors-in-patients-with-gastric-cancer
#2
Zhengyun Zou, Lianjun Zhao, Shu Su, Qin Liu, Lixia Yu, Jia Wei, Yang Yang, Juan Du, Jie Shen, Xiaoping Qian, Xiangshan Fan, Wenxian Guan, Baorui Liu
To assess the association of plasma cytokines and growth factor levels with clinical characteristics and inflammatory indices in patients with gastric cancer.Plasma samples derived from 99 gastric cancer patients were used for analysis. Levels of interferon (IFN)-γ, tumor growth factor (TGF)-β1, tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p40, IL-12p70, and vascular endothelial growth factor (VEGF) were measured by Luminex suspension array technology. The association between cytokine/growth factor levels and demographic/clinical characteristics was assessed...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29722249/the-neutrophil-to-lymphocyte-ratio-prechemotherapy-and-postchemotherapy-as-a-prognostic-marker-in-metastatic-gastric-cancer
#3
Hyunho Kim, Sang Mi Ro, Ji Hyun Yang, Joon Won Jeong, Ji Eun Lee, Sang Young Roh, In-Ho Kim
Background/Aims: Markers of inflammation have been associated with outcomes in various cancers. The purpose of this study was to evaluate whether systemic inf lammatory markers and their f luctuations can predict survival and chemotherapy response in patients with metastatic gastric cancer (mGC). Methods: We retrospectively reviewed the records of 502 patients who received first-line palliative chemotherapy for mGC between 2007 and 2013. The neutrophil-to-lymphocyte ratio (NLR) and modified Glasgow prognostic score (mGPS) were assessed before and after chemotherapy to evaluate their association with survival...
May 4, 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29681434/a-placebo-controlled-phase-ii-study-of-ruxolitinib-in-combination-with-pemetrexed-and-cisplatin-for-first-line-treatment-of-patients-with-advanced-nonsquamous-non-small-cell-lung-cancer-and-systemic-inflammation
#4
Giuseppe Giaccone, Rachel E Sanborn, Saiama N Waqar, Alex Martinez-Marti, Santiago Ponce, Huiling Zhen, Gerard Kennealey, Susan Erickson-Viitanen, Eric Schaefer
BACKGROUND: Dysregulation of the Janus kinase (JAK)/signal transducers and activators of transcription pathway contributes to abnormal inflammatory responses and poor prognosis in non-small-cell lung cancer (NSCLC). We evaluated the JAK1/JAK2 inhibitor ruxolitinib plus pemetrexed/cisplatin first-line in patients with stage IIIB/IV or recurrent nonsquamous NSCLC with systemic inflammation (modified Glasgow prognostic score [mGPS] 1/2). PATIENTS AND METHODS: Part 1 was an open-label, safety run-in, in which we assessed ruxolitinib (15 mg twice daily [b...
March 23, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29675680/a-randomized-double-blind-phase-2-study-of-ruxolitinib-or-placebo-in-combination-with-capecitabine-in-patients-with-advanced-her2-negative-breast-cancer-and-elevated-c-reactive-protein-a-marker-of-systemic-inflammation
#5
Joyce O'Shaughnessy, Angela DeMichele, Cynthia X Ma, Paul Richards, Denise A Yardley, Gail Shaw Wright, Kevin Kalinsky, Ronald Steis, Sami Diab, Gerard Kennealey, Ryan Geschwindt, Wei Jiang, Hope S Rugo
PURPOSE: The Janus-associated kinase (JAK)/signal transducer and activator of transcription pathway is a key regulator of inflammatory signaling, associated with tumorigenesis, cell survival, and progression. This randomized phase 2 trial evaluated the efficacy and safety of the addition of ruxolitinib, a JAK1/JAK2 inhibitor, to capecitabine in patients with HER2-negative advanced breast cancer and high systemic inflammation (modified Glasgow Prognostic Score [mGPS] ≥ 1). METHODS: Patients with ≤ 2 prior chemotherapy regimens for advanced or metastatic disease or hormone receptor-positive patients with disease progression on prior hormonal therapies were randomized 1:1 to 21-day cycles of ruxolitinib (n = 76) or placebo (n = 73) plus capecitabine...
April 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29643631/safety-of-the-medical-gas-pipeline-system
#6
Sushmita Sarangi, Savita Babbar, Dipali Taneja
Medical gases are nowadays being used for a number of diverse clinical applications and its piped delivery is a landmark achievement in the field of patient care. Patient safety is of paramount importance in the design, installation, commissioning, and operation of medical gas pipeline systems (MGPS). The system has to be operational round the clock, with practically zero downtime and its failure can be fatal if not restored at the earliest. There is a lack of awareness among the clinicians regarding the medico-legal aspect involved with the MGPS...
January 2018: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/29625409/relationship-of-nutritional-status-and-inflammation-with-survival-in-patients-with-advanced-cancer-in-palliative-care
#7
Marcela Souza Cunha, Emanuelly Varea Maria Wiegert, Larissa Calixto-Lima, Livia Costa Oliveira
OBJECTIVE: This study aimed to evaluate the prognostic value of nutritional and inflammatory status in patients with advanced cancer receiving palliative care. METHODS: The systemic inflammatory response was assessed using the modified Glasgow Prognostic Score (mGPS), and nutritional status was evaluated according to the Patient-Generated Subjective Global Assessment (PG-SGA) in 172 patients evaluated on their first visit in the Palliative Care Unit at the National Cancer Institute in Brazil...
February 8, 2018: Nutrition
https://www.readbyqxmd.com/read/29595652/determinants-of-lymph-node-count-and-positivity-in-patients-undergoing-surgery-for-colon-cancer
#8
Ross D Dolan, Stephen T McSorley, Paul G Horgan, Donald C McMillan
Prognosis in colon cancer is based on pathological criteria including TNM staging. However, there are deficiencies in this approach, and the lymph node ratio (LNR) has been proposed to improve the prediction of outcomes. LNR is dependent on optimal retrieval of lymph nodes-lymph node count (LNC). Recent studies have suggested that an elevated preoperative systemic inflammatory response (SIR) was associated with a lower LNC and a higher LNR. However, there are a number of potential confounding factors. The aim of the present study was to examine, in detail, these relationships in a large cohort of patients...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29581811/lymphocyte-to-monocyte-ratio-and-modified-glasgow-prognostic-score-predict-prognosis-of-lung-adenocarcinoma-without-driver-mutation
#9
Seigo Minami, Shouichi Ihara, Sung-Ho Kim, Suguru Yamamoto, Kiyoshi Komuta
Background: Neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR) and modified Glasgow prognostic score (mGPS) are useful prognostic markers based on host-related systemic inflammatory response. They have been shown as independent prognostic biomarkers in various cancers, including non-small cell lung cancer. However, there has been little evidence for a specific population of pulmonary adenocarcinoma without active epidermal growth factor receptor (EGFR) mutation. Methods: We retrospectively reviewed 159 patients who met the following criteria: histologically or cytologically diagnosed adenocarcinoma, confirmed wild-type EGFR, started first-line cytotoxic chemotherapy between July 2007 and March 2017 at our hospital, and c-stage IIIB or IV...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29574423/palliative-stenting-for-oesophagogastric-cancer-tumour-and-host-factors-and-prognosis
#10
James Hugh Park, Niall Woodley, Donald C McMillan, Paul Glen
OBJECTIVES: Palliative self-expandable metallic stent (SEMS) insertion is common in patients not suitable for resection of oesophagogastric (OG) cancer. Factors which may determine survival, however, are not clear. The present study examined the relationship between tumour and host factors, including the systemic inflammatory response and survival of patients undergoing palliative SEMS insertion. METHODS: Patients with a diagnosis of OG cancer who were considered suitable for palliative SEMS only without systemic therapy were identified...
March 23, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29530345/inflammation-and-cancer-what-a-surgical-oncologist-should-know
#11
REVIEW
Aurélien Dupré, Hassan Z Malik
Chronic inflammation is an aberrantly prolonged form of a protective response to a loss of tissue homeostasis and it is involved in several steps of the carcinogenesis process. As a result, many cancers are inflammation-related. The systemic inflammatory response is associated with survival in advanced and localized cancers. Two categories of scores have been proposed to monitor the systemic inflammatory response, those derived from protein measurement and those based on counting inflammatory cells. This review aims to provide a critical appraisal of these 2 categories of surrogate markers...
May 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29491113/the-modified-glasgow-prognostic-score-in-patients-with-gemcitabine-refractory-biliary-tract-cancer
#12
Naohiro Okano, Akiyoshi Kasuga, Kirio Kawai, Yoshiya Yamauchi, Takaaki Kobayashi, Daisuke Naruge, Fumio Nagashima, Junji Furuse
BACKGROUND: No standard second-line chemotherapy has been yet established for gemcitabine-refractory biliary tract cancer (BTC). PATIENTS AND METHODS: We conducted multivariable Cox regression analysis to examine the prognostic factors for overall survival (OS) in patients who had received gemcitabine-based treatment. RESULTS: Forty-six patients received second-line chemotherapy. The median serum carbohydrate antigen 19-9 (CA 19-9) value was 487 U/ml...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29491091/clinical-burden-of-modified-glasgow-prognostic-scale-in-colorectal-cancer
#13
Yoshinaga Okugawa, Yumiko Shirai, Yuji Toiyama, Susumu Saigusa, Asahi Hishida, Takeshi Yokoe, Koji Tanaka, Motoyoshi Tanaka, Hiromi Yasuda, Hiroyuki Fujikawa, Junichiro Hiro, Minako Kobayashi, Toshimitsu Araki, Yasuhiro Inoue, Donald C McMillan, Masato Kusunoki, Chikao Miki
BACKGROUND/AIM: This study aimed to clarify the potential of modified Glasgow Prognostic Score (mGPS) as a prognostic biomarker and reveal the significance of fish oil (FO)-enriched nutrition in colorectal cancer (CRC). PATIENTS AND METHODS: A total of 738 CRC patients from three different patient cohorts, including 670 patients in the biomarker study and 68 patients in the nutrition-intervention study, were analyzed. RESULTS: High preoperative mGPS was significantly correlated with well-recognized disease progression factors and advanced UICC stage classification...
March 2018: Anticancer Research
https://www.readbyqxmd.com/read/29467943/the-modified-glasgow-prognostic-score-is-an-independent-prognostic-indicator-in-neoadjuvantly-treated-adenocarcinoma-of-the-esophagogastric-junction
#14
Gerd Jomrich, Marlene Hollenstein, Maximilian John, Andreas Baierl, Matthias Paireder, Ivan Kristo, Aysegül Ilhan-Mutlu, Reza Asari, Matthias Preusser, Sebastian F Schoppmann
The modified Glasgow Prognostic Score (mGPS) combines the indicators of decreased plasma albumin and elevated CRP. In a number of malignancies, elevated mGPS is associated with poor survival. Aim of this study was to investigate the prognostic role of mGPS in patients with neoadjuvantly treated adenocarcinomas of the esophagogastric junction 256 patients from a prospective database undergoing surgical resection after neoadjuvant treatment between 2003 and 2014 were evaluated. mGPS was scored as 0, 1, or 2 based on CRP (>1...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29390358/prognostic-value-of-postdiagnostic-inflammation-based-scores-in-short-term-overall-survival-of-advanced-pancreatic-ductal-adenocarcinoma-patients
#15
Yuanyuan Xiao, Zhihui Xie, Zhenyi Shao, Wen Chen, Hua Xie, Guoyou Qin, Naiqing Zhao
The prognostic relevance of commonly used composite inflammation-based scores remains severely underdiscussed in pancreatic cancer (PC), especially for advanced PC. In this retrospective cohort study, we aimed to discuss the association between multiple inflammatory scores and the short-term overall survival (OS) of advanced pancreatic ductal adenocarcinoma (PDAC) patients. A total of 66 histologically confirmed PDAC patients were retrospectively analyzed. A multivariate Cox proportional hazards model was used to explore the association between 6 commonly used inflammatory scores measured right after diagnosis, Glasgow Prognostic Score (GPS), Modified Glasgow Prognostic Score (mGPS), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and the short-term OS of advanced PDAC...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29381018/prognostic-value-of-preoperative-systemic-inflammation-markers-in-localized-upper-tract-urothelial-cell-carcinoma-a-large-multicenter-cohort-analysis
#16
Sumin Son, Eu C Hwang, Seung I Jung, Dong D Kwon, Seock H Choi, Tae G Kwon, Joon H Noh, Myung K Kim, Ill Y Seo, Chul-Sung Kim, Sung G Kang, Jun Cheon, Hong K Ha, Chang W Jeong, Ja H Ku, Cheol Kwak
BACKGROUND: To investigate the prognostic value of preoperative systemic inflammation markers in upper tract urothelial carcinoma (UTUC). METHODS: A total of 1137 patients who underwent radical nephroureterectomy with bladder cuff excision at 9 institutions from 2004 to 2015, were retrospectively reviewed. The Glasgow prognostic score (GPS), modified GPS (mGPS), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) for each patient were calculated...
January 29, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29348549/preoperative-anemia-in-colorectal-cancer-relationships-with-tumor-characteristics-systemic-inflammation-and-survival
#17
Juha P Väyrynen, Anne Tuomisto, Sara A Väyrynen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J Karttunen, Markus J Mäkinen
Anemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels and erythrocyte mean corpuscular volume (MCV) levels were measured in two independent cohorts of 148 CRC patients and 208 CRC patients, and their correlation with patient and tumor characteristics, systemic inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum levels of thirteen cytokines, C-reactive protein, albumin), and survival were analyzed...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337962/the-relationship-between-right-sided-tumour-location-tumour-microenvironment-systemic-inflammation-adjuvant-therapy-and-survival-in-patients-undergoing-surgery-for-colon-and-rectal-cancer
#18
Meera Patel, Stephen T McSorley, James H Park, Campbell S D Roxburgh, Joann Edwards, Paul G Horgan, Donald C McMillan
BACKGROUND: There has been an increasing interest in the role of tumour location in the treatment and prognosis of patients with colorectal cancer (CRC), specifically in the adjuvant setting. Together with genomic data, this has led to the proposal that right-sided and left-sided tumours should be considered as distinct biological and clinical entities. The aim of the present study was to examine the relationship between tumour location, tumour microenvironment, systemic inflammatory response (SIR), adjuvant chemotherapy and survival in patients undergoing potentially curative surgery for stage I-III colon and rectal cancer...
March 6, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29335491/validation-and-optimization-of-the-systemic-inflammation-based-modified-glasgow-prognostic-score-in-predicting-postoperative-outcome-of-inflammatory-bowel-disease-preliminary-data
#19
Chenyan Zhao, Chao Ding, Tingbin Xie, Tenghui Zhang, Xujie Dai, Yao Wei, Yi Li, Jianfeng Gong, Weiming Zhu
Systemic Inflammation-Based modified Glasgow Prognostic Score (mGPS) was developed as an objective tool to grade state of inflammation. However, the association between mGPS and postoperative complications for inflammatory bowel disease (IBD) patients was still unknown. In our study, 270 IBD patients [Crohn's disease (CD), n = 186; Ulcerative colitis (UC), n = 84] from January 2013 and January 2016 who underwent elective bowel resection were retrospectively analyzed, and, the levels of preoperative C-reactive protein (CRP) and albumin were included as parameters of mGPS...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303882/inflammation-based-prognostic-scores-predict-disease-severity-in-patients-with-acute-cholecystitis
#20
Noriko Sato, Akiyoshi Kinoshita, Nami Imai, Takafumi Akasu, Takeharu Yokota, Akira Iwaku, Kazuhiko Koike, Masayuki Saruta
BACKGROUND: Although several investigators have reported that inflammation-based prognostic scores can predict disease severity in patients with various inflammatory diseases, whether or not these scores are associated with disease severity in patients with acute cholecystitis (AC) has not yet been fully clarified. PATIENTS AND METHODS: Two hundred and sixty-two patients with AC were reviewed retrospectively. We evaluated the correlations between demographic or clinical variables, including the neutrophil-to-lymphocyte ratio (NLR), the Glasgow Prognostic Score (GPS), the modified Glasgow Prognostic Score (mGPS), and the C-reactive protein/albumin (CRP/Alb) ratio, as well as the disease severity grade on the basis of the revised Tokyo guidelines...
April 2018: European Journal of Gastroenterology & Hepatology
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