keyword
MENU ▼
Read by QxMD icon Read
search

mGPS

keyword
https://www.readbyqxmd.com/read/28316218/-predictive-and-prognostic-significance-of-high-sensitivity-modified-glasgow-prognostic-score-hs-mgps-in-advanced-gastric-cancer-patients-treated-with-neoadjuvant-chemotherapy
#1
Y Cui, J Li, Y H Cao, M Y Liu, Z X Shi, T H Gao
Objective: To study the predictive and prognostic significance of high-sensitivity modified Glasgow Prognostic Score (HS-mGPS) on the effect of neoadjuvant chemotherapy for advanced gastric cancer. Methods: 117 patients with advanced gastric cancer received neoadjuvant chemotherapy with SOX (oxaliplatin+ S1) or mFOLFOX 6(oxaliplatin+ CF+ 5-FU) regimen. HS-mGPS was calculated according to blood C-reactive protein (CRP) concentration and serum albumin (ALB) level. The correlation between HS-mGPS and clinicopathological characteristics was determined and the predictors of survival were analyzed...
March 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28301959/utility-of-clinico-biological-data-for-long-term-prognosis-of-head-and-neck-terminal-cancer
#2
Taiji Kawasaki, Koichiro Wasano, Sayuri Yamamoto, Shuta Tomisato, Kaoru Ogawa
OBJECTIVE: The prognosis of terminal head and neck cancer is traditionally determined using indices such as the palliative prognosis index. We aimed to develop an alternative prognosis index using clinico-biological data. METHODS: This retrospective case-series study included 33 head and neck cancer patients whose cancer recurred despite receiving radiation therapy between April 2010 and April 2014. Clinico-biological data were collected the day patients were diagnosed as terminal...
March 16, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28299463/inflammation-based-prognostic-scores-as-indicators-to-select-candidates-for-primary-site-resection-followed-by-multimodal-therapy-among-colorectal-cancer-patients-with-multiple-metastases
#3
Tadanobu Shimura, Yuji Toiyama, Susumu Saigusa, Hiroki Imaoka, Masato Okigami, Hiroyuki Fujikawa, Junichiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Yasuhiro Inoue, Keiichi Uchida, Yasuhiko Mohri, Masato Kusunoki
BACKGROUND: Although patients with metastatic colorectal cancer (CRC) are often unable to undergo treatment after resection of primary tumors, identifying such patients before surgery is not easy. In this study, we evaluated the association among clinicopathological findings, survival outcomes, and ability to undergo multimodal therapy after primary tumor resection in patients with Stage IV CRC. METHODS: We collected clinicopathological findings and preoperative laboratory data, including carcinoembryonic antigen (CEA) and systemic inflammatory response markers for 92 patients who were treated for Stage IV CRC between 2005 and 2014...
March 15, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28213742/comparison-of-systemic-inflammatory-and-nutritional-scores-in-colorectal-cancer-patients-who-underwent-potentially-curative-resection
#4
Ryuma Tokunaga, Yasuo Sakamoto, Shigeki Nakagawa, Daisuke Izumi, Keisuke Kosumi, Katsunobu Taki, Takaaki Higashi, Tatsunori Miyata, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
BACKGROUND: Various systemic inflammatory and nutritional scores have been reported to predict postoperative outcomes. This study aimed to investigate the best systemic inflammatory and nutritional scores in colorectal cancer (CRC) patients who underwent potentially curative resection. METHOD: We evaluated 468 consecutive CRC patients in this study. Comparisons of systemic inflammatory and nutritional scores, including the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), prognostic index (PI), prognostic nutritional index (PNI), and modified Glasgow prognostic score (mGPS), were performed using univariate/multivariate analyses for patient survival...
February 17, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28150446/evaluation-of-the-modified-glasgow-prognostic-score-to-predict-outcome-in-dogs-with-newly-diagnosed-lymphoma
#5
S J Fontaine, E McCulloch, P D Eckersall, H Haining, J C Patterson Kane, J S Morris
The modified Glasgow Prognostic Score (mGPS) assigns a numerical value (0-2) from pre-treatment serum concentrations of C-reactive protein (CRP) and albumin to predict patient outcome. CRP and albumin were evaluated in 77 untreated dogs with lymphoma to determine the relationship of mGPS to clinicopathological parameters and whether it could predict progression-free (PFS) and overall survival (OS) in treated dogs. mGPS distribution was significantly associated with clinical stage, substage b, weight loss, gastrointestinal disturbances and lethargy at presentation...
February 2, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28133062/-surgical-outcome-of-palliative-surgery-for-gastric-cancer-patients-with-bowel-obstruction-due-to-peritoneal-dissemination
#6
Ryohei Kawabata, Masato Yoshikawa, Chizu Kameda, Akihiro Takata, Akinobu Yasuyama, Tae Matsumura, Chikato Koga, Masahiro Murakami, Masaki Hirota, Shingo Noura, Junzo Shimizu, Junichi Hasegawa
A retrospective cohort analysis was performed for 21 consecutive patients who underwent palliative surgery for bowel obstruction due to peritoneal metastasis from gastric cancer. Surgical site infection occurred in 5 of 21 patients, but there were no severe(Clavien-Dindo Grade III or higher)complications, and symptoms of bowel obstruction were improved in 20 of 21 patients. The median survival time was 6.6 months. The survival rate was significantly worse for patients in modified Glasgow prognostic score(mGPS)group D compared with those in mGPS group non-D(p=0...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130773/identification-of-substandard-medicines-via-disproportionality-analysis-of-individual-case-safety-reports
#7
Zahra Anita Trippe, Bruno Brendani, Christoph Meier, David Lewis
INTRODUCTION: The distribution and use of substandard medicines (SSMs) is a public health concern worldwide. The detection of SSMs is currently limited to expensive large-scale assay techniques such as high-performance liquid chromatography (HPLC). Since 2013, the Pharmacovigilance Department at Novartis Pharma AG has been analyzing drug-associated adverse events related to 'product quality issues' with the aim of detecting defective medicines using spontaneous reporting. The method of identifying SSMs with spontaneous reporting was pioneered by the Monitoring Medicines project in 2011...
January 28, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28031011/dephossitepred-a-high-accuracy-predictor-for-protein-dephosphorylation-sites
#8
Cangzhi Jia, Wenying He, Quan Zou
Many oncogenes encode proteins with a tyrosine kinase activity that appears to be directly involved in the process of transformation. Because these kinases are themselves activated for transformation by tyrosine phosphorylation, proteins that remove phosphate from tyrosine residues, protein tyrosine phosphatases (PTPs), are intuitive candidate transformation suppressors. In this study, we developed a novel PTP site prediction model, DephosSitePred, based on bi-profile sequence features. Weight parameters in the support vector machine were applied to improve the low sensitivity due to extremelyimbalanced datasets...
December 28, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28001023/modified-glasgow-prognostic-score-might-be-a-prognostic-factor-for-hepatocellular-carcinoma-a-meta-analysis
#9
Hong Chen, Nan Hu, Peng Chang, Tao Kang, Song Han, Yaoliang Lu, Maoquan Li
INTRODUCTION: Hepatocellular carcinoma (HCC) is the fifth-most common cancer. Recent studies have demonstrated that there was a relationship between modified Glasgow prognostic score (mGPS) and survival of HCC. However, the results were inconsistent. EVIDENCE ACQUISITION: The following databases were searched for relevant articles published up until June 2016: PubMed; EMBASE; Web of Science and the China National Knowledge Infrastructure. The strength of association between mGPS and OS of HCC was estimated by pooled HRs with corresponding 95% CIs...
December 21, 2016: Panminerva Medica
https://www.readbyqxmd.com/read/27987828/structural-characterization-and-antioxidant-activity-of-a-glucan-from-meripilus-giganteus
#10
Prasenjit Maity, Ashis K Nandi, Dilip K Manna, Manabendra Pattanayak, Ipsita K Sen, Sunil K Bhanja, Surajit Samanta, Bibhash C Panda, Soumitra Paloi, Krishnendu Acharya, Syed S Islam
A new water soluble glucan (MGPS), with a molecular weight ∼1.48×10(5)Da, was isolated from the fruit bodies of Meripilus giganteus by hot water extraction followed by purification through dialysis tubing cellulose membrane and sepharose 6B column chromatography. Its structural characteristics were investigated by acid hydrolysis, methylation analysis, Smith degradation and 1D/2D NMR experiments. The monosaccharide composition analysis showed that MGPS contain only glucose. The backbone of MGPS was composed of two (1→3)-β-d-glucopyranosyl, two (1→6)-β-d-glucopyranosyl, two (1→6)-α-d-glucopyranosyl, and one (1→4)-α-d-glucopyranosyl residues, out of which one (1→3)-β-d-glucopyranosyl residue was branched at O-6 position with terminal α-d-glucopyranosyl residue and one (1→4)-α-d-glucopyranosyl residue branched at O-6 position with terminal β-d-glucopyranosyl residue...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27984214/comparison-of-preoperative-inflammation-based-prognostic-scores-in-patients-with-colorectal-cancer
#11
Yoshiyuki Suzuki, Koji Okabayashi, Hirotoshi Hasegawa, Masashi Tsuruta, Kohei Shigeta, Takayuki Kondo, Yuko Kitagawa
OBJECTIVE: To evaluate the prognostic impact of the systemic inflammation score (SIS) in colorectal cancer (CRC) patients in comparison with a conventional inflammation-based score, the modified Glasgow Prognostic Score (mGPS). SUMMARY BACKGROUND DATA: The SIS, which is calculated based on the preoperative serum albumin level and lymphocyte-to-monocyte ratio, is a reported prognostic marker in clear-cell renal cell carcinoma. However, the utility of the SIS in CRC remains unclear...
December 15, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27894101/impact-of-hematological-inflammatory-markers-on-clinical-outcome-in-patients-with-salivary-duct-carcinoma-a-multi-institutional-study-in-japan
#12
Daisuke Kawakita, Yuichiro Tada, Yorihisa Imanishi, Shintaro Beppu, Kiyoaki Tsukahara, Satoshi Kano, Hiroyuki Ozawa, Kenji Okami, Yuichiro Sato, Akira Shimizu, Yukiko Sato, Chihiro Fushimi, Soichiro Takase, Takuro Okada, Hiroki Sato, Kuninori Otsuka, Yoshihiro Watanabe, Akihiro Sakai, Koji Ebisumoto, Takafumi Togashi, Yushi Ueki, Hisayuki Ota, Tomotaka Shimura, Toyoyuki Hanazawa, Shingo Murakami, Toshitaka Nagao
The prognostic role of modified Glasgow Prognostic Score (mGPS), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with salivary duct carcinoma (SDC) remains unclear. We conducted a multi-institutional retrospective cohort study of 140 SDC patients. The survival impact of these hematological markers was evaluated using multivariate proportional hazard models.High mGPS (≥1) was significantly associated with worse survival (3-year overall survival (OS): 16.7% vs 66.1%, p-value=0...
January 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/27873100/the-pretreatment-systemic-inflammatory-response-is-an-important-determinant-of-poor-pathologic-response-for-patients-undergoing-neoadjuvant-therapy-for-rectal-cancer
#13
Stephan B Dreyer, Arfon G M T Powell, Stephen T McSorley, Ashita Waterston, James J Going, Joanne Edwards, Donald C McMillan, Paul G Horgan
BACKGROUND: Not all patients respond equally to neoadjuvant chemoradiotherapy (nCRT), with subsequent effects on survival. The systemic inflammatory response has been shown to predict long-term outcomes in colorectal cancer. The current study examined the association between systemic inflammation and nCRT in patients with rectal cancer. METHODS: Between 1999 and 2010, patients who underwent nCRT were identified. Serum measurements of hemoglobin, C-reactive protein, albumin, modified Glasgow prognostic score (mGPS), and differential white cell counts were obtained before and after nCRT...
November 21, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27866811/the-modified-glasgow-prognosis-score-predicts-for-overall-and-disease-free-survival-following-cytoreductive-surgery-and-hipec-in-patients-with-pseudomyxoma-peritonei-of-appendiceal-origin
#14
G H C Tan, C A Novo, S Dayal, K Chandrakumaran, F Mohamed, T Cecil, B J Moran
BACKGROUND: The modified Glasgow prognostic score (incorporating C-reactive protein and albumin) predicts survival in patients with gastro-intestinal tract cancer but has not been evaluated in patients with peritoneal malignancy. The aim was to evaluate the modified Glasgow score preoperatively in patients undergoing complete cytoreductive surgery (CCRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP) of appendiceal origin. METHODS: Prospectively collected data from patients with PMP of appendiceal origin following CCRS and HIPEC between January 2007 and December 2011 were analysed...
February 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27854304/a-novel-inflammation-based-stage-i-stage-predicts-overall-survival-of-patients-with-nasopharyngeal-carcinoma
#15
Jian-Pei Li, Shu-Lin Chen, Xiao-Min Liu, Xia He, Shan Xing, Yi-Jun Liu, Yue-Hao Lin, Wan-Li Liu
Recent studies have indicated that inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), modified GPS (mGPS) and C-reactive protein/Albumin (CRP/Alb) ratio, platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR), have been reported to have prognostic value in patients with many types of cancer, including nasopharyngeal carcinoma (NPC). In this study, we proposed a novel inflammation-based stage, named I stage, for patients with NPC. A retrospective study of 409 newly-diagnosed cases of NPC was conducted...
November 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27847731/c-reactive-protein-albumin-ratio-as-prognostic-score-in-oral-squamous-cell-carcinoma
#16
Heung-Chul Park, Moon-Young Kim, Chul-Hwan Kim
OBJECTIVES: Many studies have examined histopathological factors and various prognostic scores related to inflammation to predict outcomes. Here, we examined the prognostic value of the C-reactive protein/albumin (CRP/alb) ratio in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS: This retrospective study included 40 patients with OSCC. Using univariate and multivariate analyses, we focused on the correlation of the CRP/alb ratio with clinicopathological characteristics and with overall survival...
October 2016: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/27798927/inflammation-based-prognostic-score-in-patients-with-living-donor-liver-transplantation-for-hepatocellular-carcinoma
#17
Norifumi Harimoto, Tomoharu Yoshizumi, Tomonari Shimagaki, Akihisa Nagatsu, Takashi Motomura, Noboru Harada, Hirohisa Okabe, Shinji Itoh, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: Inflammation-besed prognostic score including neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), modified Glasgow prognostic score (mGPS) and prognostic nutritional index (PNI) have prognostic value in various malignancies. PATIENTS AND METHODS: We retrospectively investigated their prognostic value in 213 patients with living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC). Disease-free survival (DFS) following LDLT was calculated; NLR, PLR, PNI and mGPS values in patients with and without recurrence were compared...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27760948/-significance-of-perioperative-neutrophil-lymphocyte-ratio-nlr-in-gastric-cancer-and-colon-cancer
#18
Masano Sagawa, Hirokazu Yagawa, Souichi Konno, Atsuko Usuda, Hiroyuki Maeda, Kanu Kim, Toshifumi Watanabe, Emiko Yamaya, Takebumi Usui, Hajime Yokomizo, Kazuhiko Yoshimatsu, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
BACKGROUND: We examined the significance of neutrophil lymphocyte ratio(NLR)in gastric cancer and colon cancer in the perioperative period. METHOD: There were 46 patients(21 with gastric cancer and 25 with colon cancer). We examined the association between preoperative NLR and other indicators of nutritional status, as well as the relationship between preoperative NLR and the incidence of postoperative complications(all complications/infectious complications). RESULT: NLR was higher in those with zinc<65 mg, prognostic nutritional index(PNI)≤40, and modified Glasgow prognostic score(mGPS)of 2 (p<0...
October 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27650825/prognostic-value-of-the-crp-alb-ratio-a-novel-inflammation-based-score-in-pancreatic-cancer
#19
Zuqiang Liu, Kaizhou Jin, Meng Guo, Jiang Long, Liang Liu, Chen Liu, Jin Xu, Quanxing Ni, Guopei Luo, Xianjun Yu
BACKGROUND: The C-reactive protein/albumin (CRP/Alb) ratio is associated with outcome in septic patients. However, as an inflammation-based score, its prognostic value for cancer has scarcely been investigated. METHODS: Between February 2010 and January 2015, we enrolled 386 patients with pancreatic ductal adenocarcinoma. Univariate and multivariate survival analysis between the groups were evaluated. Receiver operating characteristics curves were generated and areas under the curve (AUC) were compared to evaluate the discriminatory ability of the inflammation-based prognostic scoring systems, including CRP/Alb ratio, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and modified Glasgow prognostic score (mGPS)...
September 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27630345/preoperative-systemic-inflammation-and-complications-affect-long-term-gallbladder-carcinoma-outcomes-following-surgery-with-curative-intent
#20
Tomoyuki Abe, Hironobu Amano, Keiji Hanada, Shuji Yonehara, Tsuyoshi Kobayashi, Toshikatsu Fukuda, Masahiro Nakahara, Yoshinori Kuroda, Toshio Noriyuki
BACKGROUND/AIM: Gallbladder carcinoma (GBCA) has extremely poor outcomes. We aimed to investigate clinicopathological prognostic variables, including the modified Glasgow prognostic score (mGPS), for patients with resected GBCA. PATIENTS AND METHODS: This retrospective study included 54 patients with GBCA resected between 1996 and 2014. Univariate and multivariate analyses were performed to identify prognostic factors associated with overall and recurrence-free survival...
2016: Anticancer Research
keyword
keyword
24147
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"