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https://www.readbyqxmd.com/read/29348549/preoperative-anemia-in-colorectal-cancer-relationships-with-tumor-characteristics-systemic-inflammation-and-survival
#1
Juha P Väyrynen, Anne Tuomisto, Sara A Väyrynen, Kai Klintrup, Toni Karhu, Jyrki Mäkelä, Karl-Heinz Herzig, Tuomo J Karttunen, Markus J Mäkinen
Anemia is common in colorectal cancer (CRC) but its relationships with tumor characteristics, systemic inflammation, and survival have not been well characterized. In this study, blood hemoglobin levels and erythrocyte mean corpuscular volume (MCV) levels were measured in two independent cohorts of 148 CRC patients and 208 CRC patients, and their correlation with patient and tumor characteristics, systemic inflammatory markers (modified Glasgow Prognostic Score: mGPS; serum levels of thirteen cytokines, C-reactive protein, albumin), and survival were analyzed...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29337962/the-relationship-between-right-sided-tumour-location-tumour-microenvironment-systemic-inflammation-adjuvant-therapy-and-survival-in-patients-undergoing-surgery-for-colon-and-rectal-cancer
#2
Meera Patel, Stephen T McSorley, James H Park, Campbell S D Roxburgh, Joann Edwards, Paul G Horgan, Donald C McMillan
BACKGROUND: There has been an increasing interest in the role of tumour location in the treatment and prognosis of patients with colorectal cancer (CRC), specifically in the adjuvant setting. Together with genomic data, this has led to the proposal that right-sided and left-sided tumours should be considered as distinct biological and clinical entities. The aim of the present study was to examine the relationship between tumour location, tumour microenvironment, systemic inflammatory response (SIR), adjuvant chemotherapy and survival in patients undergoing potentially curative surgery for stage I-III colon and rectal cancer...
January 16, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29335491/validation-and-optimization-of-the-systemic-inflammation-based-modified-glasgow-prognostic-score-in-predicting-postoperative-outcome-of-inflammatory-bowel-disease-preliminary-data
#3
Chenyan Zhao, Chao Ding, Tingbin Xie, Tenghui Zhang, Xujie Dai, Yao Wei, Yi Li, Jianfeng Gong, Weiming Zhu
Systemic Inflammation-Based modified Glasgow Prognostic Score (mGPS) was developed as an objective tool to grade state of inflammation. However, the association between mGPS and postoperative complications for inflammatory bowel disease (IBD) patients was still unknown. In our study, 270 IBD patients [Crohn's disease (CD), n = 186; Ulcerative colitis (UC), n = 84] from January 2013 and January 2016 who underwent elective bowel resection were retrospectively analyzed, and, the levels of preoperative C-reactive protein (CRP) and albumin were included as parameters of mGPS...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29303882/inflammation-based-prognostic-scores-predict-disease-severity-in-patients-with-acute-cholecystitis
#4
Noriko Sato, Akiyoshi Kinoshita, Nami Imai, Takafumi Akasu, Takeharu Yokota, Akira Iwaku, Kazuhiko Koike, Masayuki Saruta
BACKGROUND: Although several investigators have reported that inflammation-based prognostic scores can predict disease severity in patients with various inflammatory diseases, whether or not these scores are associated with disease severity in patients with acute cholecystitis (AC) has not yet been fully clarified. PATIENTS AND METHODS: Two hundred and sixty-two patients with AC were reviewed retrospectively. We evaluated the correlations between demographic or clinical variables, including the neutrophil-to-lymphocyte ratio (NLR), the Glasgow Prognostic Score (GPS), the modified Glasgow Prognostic Score (mGPS), and the C-reactive protein/albumin (CRP/Alb) ratio, as well as the disease severity grade on the basis of the revised Tokyo guidelines...
January 4, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29245945/high-sensitivity-modified-glasgow-prognostic-score-hs-mgps-is-superior-to-the-mgps-in-esophageal-cancer-patients-treated-with-chemoradiotherapy
#5
Peng Chen, Min Fang, Qiuyan Wan, Xuebang Zhang, Tao Song, Shixiu Wu
The present study compared the prognostic value of the modified Glasgow prognostic score (mGPS) and high-sensitivity mGPS (HS-mGPS) in unresectable locally advanced esophageal squamous cell carcimona (LAESCC) patients treated with concurrent chemoradiotherapy (CCRT). The baseline data of 163 eligible patients were retrospectively collected. Patients with a C-reactive protein (CRP) ≤ 10 mg/l and albumin ≥ 35 g/l were allocated to mGPS-0 group. Patients with only elevated CRP (> 10 mg/l) were assigned to mGPS-1 group...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29234999/prognostic-significance-of-serum-inflammatory-markers-in-gastric-cancer
#6
Arfon G M T Powell, Debora Parkinson, Neil Patel, David Chan, Adam Christian, Wyn G Lewis
BACKGROUND: The aim of this study was to assess the relative prognostic value of biomarkers to measure the systemic inflammatory response (SIR) and improve prognostic modeling in a cohort of patients undergoing potentially curative surgery for gastric adenocarcinoma. The hypothesis was that a single SIR biomarker would be associated with the most prognostic value. METHODS: Consecutive 331 patients undergoing surgery for gastric cancer between 2004 and 2016 within a regional UK cancer network were identified...
October 4, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29228679/prognostic-value-of-the-c-reactive-protein-albumin-ratio-car-in-patients-with-operable-soft-tissue-sarcoma
#7
Yao Liang, Wei Xiao, Yuan-Xiang Guan, Wei Wang, Huo Ying Chen, Cheng Fang, Xing Zhang, Zhi-Wei Zhou
Background: The preoperative C-reactive protein/Albumin ratio (CAR) is valuable for predicting the prognosis of patients with various types of cancers. The aim of the present study is to investigate the prognostic value of the preoperative CAR and compare it with other systemic inflammatory response markers in patients with soft tissue sarcoma (STS). Methods: This retrospective study included 206 patients with STS. The optimal cutoff value of the CAR was determined by receiver operating characteristic (ROC) analysis...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29196718/the-role-of-the-systemic-inflammatory-response-in-predicting-outcomes-in-patients-with-operable-cancer-systematic-review-and-meta-analysis
#8
Ross D Dolan, Jason Lim, Stephen T McSorley, Paul G Horgan, Donald C McMillan
Cancer remains a leading causes of death worldwide and an elevated systemic inflammatory response (SIR) is associated with reduced survival in patients with operable cancer. This review aims to examine the evidence for the role of systemic inflammation based prognostic scores in patients with operable cancers. A wide-ranging literature review using targeted medical subject headings for human studies in English was carried out in the MEDLINE, EMBASE, and CDSR databases until the end of 2016. The SIR has independent prognostic value, across tumour types and geographical locations...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192354/prognostic-implication-of-inflammation-based-prognostic-scores-in-patients-with-intrahepatic-cholangiocarcinoma-treated-with-first-line-gemcitabine-plus-cisplatin
#9
Hyungwoo Cho, Changhoon Yoo, Kyu-Pyo Kim, Jae Ho Jeong, Jihoon Kang, Heung-Moon Chang, Sang Soo Lee, Do Hyun Park, Tae Jun Song, Sung Koo Lee, Myung-Hwan Kim, Han Chu Lee, Young-Suk Lim, Kang Mo Kim, Ju Hyun Shim, Shin Hwang, Gi-Won Song, Deok-Bog Moon, Jae Hoon Lee, Young-Joo Lee, Baek-Yeol Ryoo
Background We aimed to comprehensively evaluate the prognostic value of inflammation-based prognostic scores, including the modified Glasgow Prognostic Score (mGPS), neutrophil-lymphocyte ratio (NLR), and platelet-lymphocyte ratio (PLR), exclusively in patients with advanced intrahepatic cholangiocarcinoma (iCCA). Methods Between May 2010 and April 2015, 305 patients with histologically documented unresectable or metastatic iCCA were treated with first-line gemcitabine plus cisplatin (GemCis). Among these, 257 patients had complete data for inflammation-based prognostic scores and were included...
December 1, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29178362/the-relationship-between-18f-fdg-petct-derived-markers-of-tumour-metabolism-and-systemic-inflammation-in-patients-with-recurrent-disease-following-surgery-for-colorectal-cancer
#10
Stephen T McSorley, Bo Y Khor, Kwong Tsang, David Colville, Sai Han, Paul G Horgan, Donald C McMillan
AIM: 18 F FDG-PETCT derived markers of tumour metabolism have been reported to have prognostic significance in a variety of tumours. Host inflammation is also recognised to have prognostic significance. The aim of the present study was to investigate the relationship between these markers and host systemic inflammation in patients undergoing elective surgery for colorectal cancer. METHODS: Patients with histologically confirmed colorectal cancer, who underwent elective surgery between 2008 and 2015, who also underwent 18 F FDG-PETCT, at a single centre were included (n =103)...
November 25, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29173768/c-reactive-protein-albumin-ratio-is-an-independent-prognostic-predictor-of-tumor-recurrence-in-stage-iiia-n2-lung-adenocarcinoma-patients
#11
Yoshikane Yamauchi, Seyer Safi, Thomas Muley, Arne Warth, Felix J F Herth, Hendrik Dienemann, Hans Hoffmann, Martin E Eichhorn
OBJECTIVE: To systematically evaluate the prognostic value of nutrition/inflammation-based markers for recurrence-free survival (RFS) in pN2-stage IIIA lung adenocarcinoma patients. MATERIALS AND METHODS: Data from 156 patients who had pathologically confirmed pN2-stage IIIA primary lung adenocarcinoma and received complete surgical resection from 2010 to 2014 were retrospectively analyzed. The data for Glasgow prognostic score (GPS), modified GPS (mGPS), high-sensitivity mGPS, C-reactive protein/albumin ratio (CAR), neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and prognostic nutritional index were analyzed...
December 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29142183/worse-preoperative-status-based-on-inflammation-and-host-immunity-is-a-risk-factor-for-surgical-site-infections-in-colorectal-cancer-surgery
#12
Masano Sagawa, Kazuhiko Yoshimatsu, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
OBJECTIVE: The modified Glasgow Prognostic Score (mGPS) is an inflammation-based measure of malnutrition that reflects a state of cachexia in cancer patients. We evaluated mGPS as an index to predict surgical site infection (SSI) incidence in patients undergoing colorectal cancer surgery. SUBJECTS AND METHODS: We retrospectively analyzed 351 patients who underwent colon cancer resection. Factors correlated with the incidence of SSIs were identified by logistic analysis and stepwise selection...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/29107348/validation-of-the-modified-glasgow-prognostic-score-mgps-in-recurrent-ovarian-cancer-roc-analysis-of-patients-enrolled-in-the-gcig-symptom-benefit-study-sbs
#13
Felicia T Roncolato, Dominique Berton-Rigaud, Rachel O'Connell, Anne Lanceley, Jalid Sehouli, Luke Buizen, Aikou Okamoto, Eriko Aotani, Domenica Lorusso, Paul Donnellan, Amit Oza, Elisabeth Avall-Lundqvist, Jonathan Berek, Felix Hilpert, Jonathan A Ledermann, Marie Christine Kaminsky, Martin R Stockler, Madeleine T King, Michael Friedlander
BACKGROUND: Modified Glasgow Prognostic Score (mGPS) is predictive of survival in many advanced cancers, but has not been evaluated in recurrent ovarian cancer (ROC). The aim was to determine validity of mGPS in ROC, investigate its associations with health related quality of life (HRQL) and ECOG performance status (PS). METHODS: mGPS is based on serum C reactive protein (CRP) and albumin, with scores ranging from 0 (least) to 2 (most). HRQL was measured with EORTC QLQ C-30 and OV-28...
October 26, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29066696/-relationship-between-surgical-site-infection-ssi-incidence-and-prognosis-in-colorectal-cancer-surgery
#14
Masano Sagawa, Hajime Yokomizo, Kazuhiko Yoshimatsu, Yuki Yano, Sachiyo Okayama, Akiko Sakuma, Masaya Satake, Yasufumi Yamada, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
We examined the relationship between risk factors for surgical site infections(SSIs)and prognosis in 440 patients who underwent colon cancer surgery. We evaluated factors related to SSIs(GradeB II)and compared survival rates by stage. SSIs were observed in 36 patients. An increased SSI incidence was associated with pulmonary dysfunction, mGPS=2, CONUT≥2, PNI≤40, NLR>4.3, location(rectum), depth of tumor invasion(Bsubserosa, SS), lymph node metastasis, laparotomy, resection of other organs, colostomy, blood loss(large), and operative time(long)...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066691/-a-prognostic-factor-based-on-inflammation-nutrition-and-immune-status-for-fstage-ii-iii-colorectal-cancer
#15
Kazuhiko Yoshimatsu, Masano Sagawa, Hajime Yokomizo, Yuki Yano, Sachiyo Okayama, Masaya Satake, Atsuo Matsumoto, Yasufumi Yamada, Shinichi Asaka, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Takeshi Shimakawa, Takao Katsube, Yoshihiko Naritaka
INTRODUCTION: We investigated whether the prognostic nutritional index(PNI), controlling nutritional status(CONUT), modified Glasgow prognostic score(mGPS), and the neutrophil count/lymphocyte number ratio(NLR)could be prognostic factors for fStage II/III colorectal cancer. SUBJECTS AND METHODS: The subjects were 115 patients with fStage II/III colorectal cancer who underwent curative resection. We studied the relationship with 3-year disease-free survival(DFS)and 5-year survival rate(OS)...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29066690/-preoperative-prognostic-nutrition-index-is-a-predictive-factor-of-complications-in-laparoscopic-colorectal-surgery
#16
Yuki Yano, Masano Sagawa, Hajime Yokomizo, Sachiyo Okayama, Yasufumi Yamada, Takebumi Usui, Kentaro Yamaguchi, Shunichi Shiozawa, Kazuhiko Yoshimatsu, Takeshi Shimakawa, Takao Katsube, Hiroyuki Kato, Yoshihiko Naritaka
Paitients and methods: We retrospectively reviewed a database of 188 patients who underwent resection for colorectal cancer with laparoscopic surgery between July 2007 and March 2015. The prognostic nutrition index(PNI), modified Glas- gow prognostic score(mGPS), controlling nutritional status(CONUT), and neutrophil/lymphocyte ratio(N/L)were measured in these patients. We examined the association between postoperative complications and clinicopathological factors. RESULTS: The study included 110 men and 78 women...
October 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29044941/clinical-significance-of-changes-in-systemic-inflammatory-markers-and-carcinoembryonic-antigen-levels-in-predicting-metastatic-colorectal-cancer-prognosis-and-chemotherapy-response
#17
In-Ho Kim, Ji Eun Lee, Ji Hyun Yang, Joon Won Jeong, Sangmi Ro, Myung Ah Lee
AIM: Metastatic colorectal cancer (mCRC) is associated with poor prognosis, and biomarkers are required for predicting survival and chemotherapy response. This study aimed to evaluate the significance of changes in systemic inflammatory markers and carcinoembryonic antigen (CEA) levels in predicting mCRC prognosis and chemotherapy response. METHODS: In this retrospective study, 503 patients who received first-line palliative chemotherapy for mCRC between 2008 and 2014 at a tertiary hospital in Korea were evaluated...
October 18, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28982904/clinical-significance-of-c-reactive-protein-to-albumin-ratio-with-rectal-cancer-patient-undergoing-chemoradiotherapy-followed-by-surgery
#18
Shozo Ide, Yuji Toiyama, Yoshinaga Okugawa, Satoshi Oki, Hiromi Yasuda, Hiroyuki Fujikawa, Shigeyuki Yoshiyama, Junitiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Masato Kusunoki
BACKGROUND/AIM: This study was designed to evaluate the clinical significance of the C-reactive protein-to-albumin ratio (CAR) in patients with rectal cancer undergoing preoperative chemoradiotherapy (CRT) followed by surgery. PATIENTS AND METHODS: This retrospective study evaluated the correlation between CAR and prognosis in 115 patients with locally advanced rectal cancer. We also carried out subgroup analyses limited to patients with low modified Glasgow prognosis score (mGPS) (score 0) or pathological TNM stage I-II [ypN(-)]...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28967380/staging-the-tumor-and-staging-the-host-a-two-centre-two-country-comparison-of-systemic-inflammatory-responses-of-patients-undergoing-resection-of-primary-operable-colorectal-cancer
#19
James H Park, Mitsuru Ishizuka, Stephen T McSorley, Keiichi Kubota, Campbell S D Roxburgh, Hitoshi Nagata, Kazutoshi Takagi, Yoshimi Iwasaki, Taku Aoki, Paul G Horgan, Donald C McMillan
BACKGROUND: How systemic inflammation-based prognostic scores such as the modified Glasgow Prognostic Score (mGPS) and neutrophil:lymphocyte ratio (NLR) differ across populations of patients with colorectal cancer (CRC) remains unknown. The present study examined the mGPS and NLR in patients from United Kingdom (UK) and Japan. METHODS: Patients undergoing resection of TNM I-III CRC in two centres in the UK and Japan were included. Differences in clinicopathological characteristics and mGPS (0-CRP≤10 mg/L, 1-CRP>10 mg/L, 2-CRP>10 mg/L, albumin<35 g/L) and NLR (≤5/>5) were examined...
September 20, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28959185/mediating-role-of-the-reward-network-in-the-relationship-between-the-dopamine-multilocus-genetic-profile-and-depression
#20
Liang Gong, Cancan He, Yingying Yin, Hui Wang, Qing Ye, Feng Bai, Yonggui Yuan, Haisan Zhang, Luxian Lv, Hongxing Zhang, Zhijun Zhang, Chunming Xie
Multiple genetic loci in the dopamine (DA) pathway have been associated with depression symptoms in patients with major depressive disorder (MDD). However, the neural mechanisms underlying the polygenic effects of the DA pathway on depression remain unclear. We used an imaging genetic approach to investigate the polygenic effects of the DA pathway on the reward network in MDD. Fifty-three patients and 37 cognitively normal (CN) subjects were recruited and underwent resting-state functional magnetic resonance imaging (R-fMRI) scans...
2017: Frontiers in Molecular Neuroscience
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