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https://www.readbyqxmd.com/read/29773800/x-ray-structure-of-a-carpet-like-antimicrobial-defensin-phospholipid-membrane-disruption-complex
#1
Michael Järvå, Fung T Lay, Thanh Kha Phan, Cassandra Humble, Ivan K H Poon, Mark R Bleackley, Marilyn A Anderson, Mark D Hulett, Marc Kvansakul
Defensins are cationic antimicrobial peptides expressed throughout the plant and animal kingdoms as a first line of defense against pathogens. Membrane targeting and disruption is a crucial function of many defensins, however the precise mechanism remains unclear. Certain plant defensins form dimers that specifically bind the membrane phospholipids phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate, thereby triggering the assembly of defensin-lipid oligomers that permeabilize cell membranes. To understand this permeabilization mechanism, here we determine the crystal structure of the plant defensin NaD1 bound to PA...
May 17, 2018: Nature Communications
https://www.readbyqxmd.com/read/29750507/directed-atom-by-atom-assembly-of-dopants-in-silicon
#2
Bethany M Hudak, Jiaming Song, Hunter Sims, M Claudia Troparevsky, Travis S Humble, Sokrates T Pantelides, Paul C Snijders, Andrew R Lupini
The ability to controllably position single atoms inside materials is key for the ultimate fabrication of devices with functionalities governed by atomic-scale properties. Single bismuth dopant atoms in silicon provide an ideal case study in view of proposals for single-dopant quantum bits. However, bismuth is the least soluble pnictogen in silicon, meaning that the dopant atoms tend to migrate out of position during sample growth. Here we demonstrate epitaxial growth of thin silicon films doped with bismuth...
May 11, 2018: ACS Nano
https://www.readbyqxmd.com/read/29725719/understanding-the-tolerance-of-the-industrial-yeast-saccharomyces-cerevisiae-against-a-major-class-of-toxic-aldehyde-compounds
#3
REVIEW
ZongLin Lewis Liu
Development of the next-generation biocatalyst is vital for fermentation-based industrial applications and a sustainable bio-based economy. Overcoming the major class of toxic compounds associated with lignocellulose-to-biofuels conversion is one of the significant challenges for new strain development. A significant number of investigations have been made to understand mechanisms of the tolerance for industrial yeast. It is humbling to learn how complicated the cell's response to the toxic chemicals is and how little we have known about yeast tolerance in the universe of the living cell...
May 3, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29724148/medical-response-to-the-declaration-of-the-first-world-war-the-case-of-edwin-seaborn
#4
Alexandra C Istl, Vivian C McAlister
At the turn of the 20th century, Dr Edwin Seaborn was starting his surgical and academic career at Western University in Ontario. When war was declared in 1914, Seaborn prevailed upon the university's president to offer the Canadian government a fully staffed hospital for deployment overseas. Initially declined by the War Office in Ottawa, the university's offer was later accepted after mounting casualties stretched the capacity of the Canadian Army Medical Corps, and Seaborn was granted command of the new No...
January 1, 2018: Journal of Medical Biography
https://www.readbyqxmd.com/read/29720531/improving-on-the-humble-spud
#5
Scott Hayes
No abstract text is available yet for this article.
May 2018: Plant Physiology
https://www.readbyqxmd.com/read/29710340/health-insurance-for-asian-americans-native-hawaiians-and-pacific-islanders-under-the-affordable-care-act
#6
John J Park, Sarah Humble, Benjamin D Sommers, Graham A Colditz, Arnold M Epstein, Howard K Koh
No abstract text is available yet for this article.
April 30, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29706125/uterine-paramesonephric-cysts-in-sprague-dawley-rats-from-national-toxicology-program-studies
#7
Daven N Jackson-Humbles, John Curtis Seely, Ronald A Herbert, David E Malarkey, Barry S McIntyre, Paul M Foster, Darlene Dixon
Congenital uterine wall cysts arising from paramesonephric (Müllerian) and mesonephric (Wolffian) ducts are typically incidental findings in most species. We used immunohistochemistry to characterize and determine the origin of uterine cysts in Sprague-Dawley (SD) rats from multigeneration studies conducted by the National Toxicology Program. Subserosal uterine cysts were observed in 20 of the 2,400 SD rats evaluated in five studies, and 10 cysts were characterized for this study. Single cysts were unilocular, fluid-filled, and occurred throughout the uterus...
January 1, 2018: Toxicologic Pathology
https://www.readbyqxmd.com/read/29693472/single-piece-fronto-temporo-orbito-zygomatic-craniotomy-a-personal-experience-and-review-of-surgical-technique
#8
Manish Sharma, Sridhar Shastri
BACKGROUND: Fronto-Temporo-Orbito-Zygomatic (FTOZ) craniotomy has progressed from its humble beginnings. Numerous variations including one piece, two piece and even three piece FTOZ craniotomies have been described. The ideal technique still remains elusive and its use remains restricted to a few specialised centres even when benefits far outweigh the surgical difficulties. OBJECTIVE: To analyse 11 cases in which single piece FTOZ craniotomy was used and to review the steps of surgery along with its advantages...
April 25, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29664617/expanded-theory-of-h-and-j-molecular-aggregates-the-effects-of-vibronic-coupling-and-intermolecular-charge-transfer
#9
Nicholas J Hestand, Frank C Spano
The electronic excited states of molecular aggregates and their photophysical signatures have long fascinated spectroscopists and theoreticians alike since the advent of Frenkel exciton theory almost 90 years ago. The influence of molecular packing on basic optical probes like absorption and photoluminescence was originally worked out by Kasha for aggregates dominated by Coulombic intermolecular interactions, eventually leading to the classification of J- and H-aggregates. This review outlines advances made in understanding the relationship between aggregate structure and photophysics when vibronic coupling and intermolecular charge transfer are incorporated...
April 17, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29652406/individual-importance-weighting-of-domain-satisfaction-ratings-does-not-increase-validity
#10
Julia M Rohrer, Stefan C Schmukle
Bottom-up models of life satisfaction are based on the assumption that individuals judge the overall quality of their lives by aggregating information across various life domains, such as health, family, and income. This aggregation supposedly involves a weighting procedure because individuals care about different parts of their lives to varying degrees. Thus, composite measures of well-being should be more accurate if domain satisfaction scores are weighted by the importance that respondents assign to the respective domains...
2018: Collabra. Psychology
https://www.readbyqxmd.com/read/29624171/the-humble-case-report-bottom-of-the-evidence-based-medical-pyramid-or-the-foundation-of-clinical-research
#11
Darren Mylotte
No abstract text is available yet for this article.
April 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29608141/senescent-cells-a-therapeutic-target-for-cardiovascular-disease
#12
Bennett G Childs, Hu Li, Jan M van Deursen
Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the process, senescent cells have attracted attention as a therapeutic target for age-related diseases, including cardiovascular disease (CVD), the leading cause of morbidity and mortality in the elderly. Given the aging global population and the inadequacy of current medical management, attenuating the health care burden of CVD would be transformative to clinical practice...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29588030/the-mouse-as-a-model-organism-for-assessing-anesthetic-sensitivity
#13
Andrzej Z Wasilczuk, Kaitlyn L Maier, Max B Kelz
The mouse has been used in many medical fields as a powerful model to reveal the genetic basis of human physiology and disease. The past two decades have witnessed an enormous wealth of genetic and informatic resources dedicated to this humble organism. With the ongoing revolution in mapping neural circuitry governing behavior, the mouse is an ideal model organism poised to unravel the mysteries of general anesthetic action. This chapter will describe and provide guidelines for anesthetic phenotyping in the mouse including both motor-dependent and motor-independent assessments...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29579406/a-life-in-food-a-grain-of-salt-and-some-humble-pie
#14
Michael J Gibney
From my senior school days, I had wanted to pursue a career in food. In quite what capacity I was not too sure. So my starting points were within the fields of animal nutrition before moving for the major part of my career to medical schools to study human nutrition and health. My career scientific achievements lie within the Kuhnian spectrum of normal science, but within that normality, I was always one to challenge conventional wisdom. An academic career is about more than just research. It is about teaching and not just the minutiae of nutrition, but about life and living, about challenges and failures...
March 26, 2018: Annual Review of Nutrition
https://www.readbyqxmd.com/read/29555257/biomedical-waste-management-in-ayurveda-hospitals-current-practices-future-prospectives
#15
REVIEW
Renju Rajan, Delvin T Robin, Vandanarani M
Biomedical waste management is an integral part of traditional and contemporary system of health care. The paper focuses on the identification and classification of biomedical wastes in Ayurvedic hospitals, current practices of its management in Ayurveda hospitals and its future prospective. Databases like PubMed (1975-2017 Feb), Scopus (1960-2017), AYUSH Portal, DOAJ, DHARA and Google scholar were searched. We used the medical subject headings 'biomedical waste' and 'health care waste' for identification and classification...
March 16, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29553987/chronic-postsurgical-pain-and-cancer-the-catch-of-surviving-the-unsurvivable
#16
Stephen R Humble, Nicolas Varela, Asantha Jayaweera, Arun Bhaskar
PURPOSE OF REVIEW: Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer. Unfortunately, general consensus is lacking as to how best reduce the risk of developing CPSP. RECENT FINDINGS: Cancer is now not always a short-lived, fatal disease and is now moving towards a chronic illness. Poorly managed perioperative pain is the greatest risk factor for CPSP...
March 16, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29550644/a-web-based-resource-for-promoting-equity-in-midwifery-education-and-training-towards-meaningful-diversity-and-inclusion
#17
Kristin J Effland, Karen Hays
Increasing the midwifery workforce requires that aspiring midwives complete education and training, but structural racism and microaggressions impact the lives of underrepresented midwifery students and apprentices, adding stressors and disparities to the usual demanding educational challenges. In order to be resilient, students rely on preceptors, faculty, administrators and institutions to promote equity. Equity-focused learning environments improve student experiences and success rates, and better prepare all students to provide culturally humble and sensitive care to diverse childbearing persons and other essential competencies outlined by the International Confederation of Midwives...
February 15, 2018: Midwifery
https://www.readbyqxmd.com/read/29541573/spontaneous-resolution-of-a-confounding-insular-lesion
#18
Ali S Haider, Christopher S Graffeo, Avital Perry, Lucas P Carlstrom, Terry C Burns
Insular gliomas were previously considered inoperable lesions and were typically treated via biopsy, chemotherapy and/or radiation, if not observation alone. Stereotactic biopsies of low grade insular gliomas can underestimate tumor grade or fail to establish malignancy. Moreover, the survival advantages of maximal safe resection for insular lesions are increasingly being recognized. As such, early surgical resection is increasingly being performed. As with most lesions, a differential diagnosis exists for apparent insular gliomas, with definitive diagnosis generally obtained upon resection...
January 11, 2018: Curēus
https://www.readbyqxmd.com/read/29517051/ode-to-the-humble-southern-blot-in-the-era-of-exomes
#19
EDITORIAL
Alex R Paciorkowski
No abstract text is available yet for this article.
February 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29503281/from-syrian-refugee-to-dishwasher-to-heart-doctor-the-inspirational-story-of-hero-and-humanitarian-dr-heval-kelli
#20
Meira Mahmoud Yasin
It has been said that those with the least are often the ones with the most to give. This proved to be true for a Syrian refugee turned cardiologist who provides care in communities that are poor and underserved including refugees, immigrants, minorities, those of low socioeconomic status, and other vulnerable populations. Dr. Heval Kelli is the epitome of a kind-hearted, humble, genuine hero, through his dedication to serving humanity. Between providing health care to those in need, educating future generations of doctors, mentoring high school students, and advocating for the less fortunate, his life is truly his message to the world...
2018: Journal of Health Care for the Poor and Underserved
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