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Crohn's and TNF

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https://www.readbyqxmd.com/read/28202618/the-inflammatory-bowel-disease-associated-autophagy-gene-atg16l1t300a-acts-as-a-dominant-negative-variant-in-mice
#1
Ping Gao, Hongtao Liu, Huarong Huang, Qi Zhang, Warren Strober, Fuping Zhang
The basis of the increased risk for Crohn's disease conferred by the Atg16L1T300A polymorphism is incompletely understood. An important step forward came from the recent demonstration that the murine equivalent of Atg16L1T300A (Atg16L1T316A) exhibits increased susceptibility to caspase 3-mediated cleavage and resulting decreased levels of full-length Atg16L1 in macrophages. However, although this finding showed that this polymorphism is a loss-of-function abnormality, it did not address the possibility that this polymorphism also affects the function of a normal Atg16L1 allele in heterozygous mice...
February 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28191024/recent-trends-in-pharmacological-activity-of-alkaloids-in-animal-colitis-potential-use-for-inflammatory-bowel-disease
#2
REVIEW
Ana Cristina Alves de Almeida, Felipe Meira de-Faria, Ricardo José Dunder, Luis Paulo Bognoni Manzo, Alba Regina Monteiro Souza-Brito, Anderson Luiz-Ferreira
Inflammatory bowel disease (IBD) is a chronic and disrupted inflammation of the gastrointestinal tract. IBD have two main conditions, Crohn's disease and ulcerative colitis, and have been extensively investigated in recent years. Antibiotics derived from salicylates, steroids, immunosuppressors, and anti-TNF therapy are part of the therapeutic arsenal for IBD. However, very often patients stop responding to treatments over the time. In this context, searching for alternative agents is crucial for IBD clinical management...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28186172/appropriateness-of-reference-genes-for-normalizing-messenger-rna-in-mouse-2-4-dinitrobenzene-sulfonic-acid-dnbs-induced-colitis-using-quantitative-real-time-pcr
#3
Nour Eissa, Laëtitia Kermarrec, Hayam Hussein, Charles N Bernstein, Jean-Eric Ghia
2,4-Dinitrobenzene sulfonic acid (DNBS)-induced colitis is an experimental model that mimics Crohn's disease. Appropriateness of reference genes is crucial for RT-qPCR. This is the first study to determine the stability of reference gene expression (RGE) in mice treated with DNBS. DNBS experimental Colitis was induced in male C57BL/6 mice. RNA was extracted from colon tissue and comprehensive analysis of 13 RGE was performed according to predefined criteria. Relative colonic TNF-α and IL-1β mRNA levels were calculated...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28175186/p673-intra-abdominal-collections-in-crohn-s-disease-outcomes-following-anti-tnf-therapy
#4
K Subramaniam, M Tweedale, P Pavli
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175184/p628-anti-tnf-therapy-in-refractory-pouchitis-and-crohn-s-disease-like-complications-of-the-pouch-after-ileal-pouch-anal-anastomosis-following-colectomy-for-ulcerative-colitis-a-systematic-review-and-meta-analysis
#5
M Huguet, B Pereira, M Goutte, F Goutorbe, C Allimant, M Reymond, G Bommelaer, A Buisson
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175136/p419-concentrations-of-anti-tnf-agents-in-non-inflamed-intestinal-tissue-are-associated-with-the-long-term-outcome-of-patients-with-crohn-s-disease
#6
T Yoshihara, S Shinzaki, S Kawai, S Iwatani, T Yamaguchi, M Araki, S Hiyama, T Inoue, Y Hayashi, K Watabe, H Iijima, T Takehara
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175130/p462-long-term-outcomes-of-anti-tnf-therapy-discontinuation-in-patients-with-penetrating-crohn-s-disease
#7
M Gompertz, E Ricart, I Ordás, I Alfaro, A Lόpez, M Gallego, R Barastegui, A Giner, A Vara, M Masamunt, J Panés
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175124/p482-early-anti-tnf-immunomodulator-therapy-is-associated-with-better-clinical-outcomes-in-asian-patients-with-crohn-s-disease-with-poor-prognostic-factors
#8
E H Oh, K Oh, H Seo, K Chang, G-U Kim, E M Song, M Seo, H-S Lee, E J Kwon, S W Hwang, S H Park, D-H Yang, K-J Kim, J-S Byeon, S-J Myung, S-K Yang, B D Ye
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175106/p491-comparison-of-the-durability-of-response-to-subcutaneous-anti-tnf-therapy-between-ulcerative-colitis-and-crohn-s-disease
#9
G Mellotte, C McShane, J O'Connell, S Mc Kiernan, F Mac Carthy, D Kevans
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28175070/p401-anti-tnf-treatments-in-crohn-s-disease-and-improvement-in-work-productivity-and-quality-of-life-an-observational-study-from-turkey
#10
M Törüner, M Başaranoğlu, Ö Atuğ, Ö Şentürk, F Akyüz, B Ünsal, H Över Hamzaoğlu, F Tekin, O Sezgin, H Akpınar, A F Çelik, A Tezel, H S Göktürk, T Kav
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28174918/dop013-definition-of-therapeutic-response-criteria-using-mri-in-crohn-s-disease-patients-treated-with-anti-tnf-therapy-a-multicenter-prospective-study-the-irma-study
#11
A Buisson, L Messadeg, G Bouguen, F Goutorbe, J-M Reimund, M Goutte, C Sautel, C Duron, J Scanzi, M Reymond, C Allimant, M Dapoigny, G Bommelaer, B Pereira, C Hordonneau
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28173071/p636-reproducibility-of-the-main-prognostic-factors-for-postoperative-recurrence-in-a-cohort-of-patients-with-crohn-s-disease-under-anti-tnf-therapy
#12
S Raimundo Fernandes, L Correia, C Baldaia, P Moura Santos, A Rita Gonçalves, A Valente, J Velosa
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172874/p398-an-objective-measure-of-response-to-treatment-for-patients-with-crohn-s-perianal-fistulas-on-anti-tnf-treatment
#13
K Sahnan, P F Lung, S O Adegbola, D Burling, J Burn, P J Tozer, A Gupta, O D Faiz, R K Phillips, A L Hart
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172733/dop050-serum-proteomic-analysis-defines-novel-circulating-inflammatory-markers-for-crohn-s-disease-and-response-to-anti-tnf-therapy
#14
H Korf, J Sabino, V Ballet, M de Bruyn, G Van Assche, M Ferrante, S Vermeire
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172698/p425-biosimilar-infliximab-in-real-life-crohn-s-disease-treatment-in-anti-tnf-alpha-na%C3%A3-ve-and-non-na%C3%A3-ve-patients-in-comparison-to-biologic-originator-a%C3%A2-comparative-observational-cohort-study
#15
M Kaniewska, A Moniuszko, K Maciejewska, G Rydzewska
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172566/dop075-efficacy-of-filgotinib-a-selective-jak1-inhibitor-is-independent-of-prior-anti-tnf-exposure-subgroup-analysis-of-the-phase-2-fitzroy-study-in-moderate-to-severe-crohn-s-disease
#16
G D'Haens, S Schreiber, R Petryka, T Kuehbacher, X Hebuterne, X Roblin, M Klopocka, A Goldis, M Wisniewska-Jarosinska, A Baranovsky, R Sike, K Stoyanova, L Meuleners, C Tasset, A Van der Aa, P Harrison, S Vermeire
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172546/p588-ustekinumab-for-the-treatment-of-crohn-s-disease-patients-with-tnf-antagonist-induced-psoriasis-real-life-experience-from-a-tertiary-referral-center-through-week-54
#17
T Kuehbacher, R Abu Hashem, N Langel, S Schreiber, O Drvarov
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172537/p493-efficacy-of-anti-tnf-for-internal-fistula-in-crohn-s-disease-results-from-a-retrospective-multicenter-cohort-study
#18
T Kobayashi, A Hishida, H Tanaka, S Bamba, A Yamada, F Toshimitsu, S Shinichiro, N Kamata, T Yoshino, T Hibi
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172530/p076-il-26-genetic-polymorphisms-impair-cytokine-response-to-bacterial-dna-translocation-and-increase-anti-tnf-consumption-in-patients-with-crohn-s-disease
#19
P Piñero, O Juanola, A Gutiérrez, P Zapater, P Giménez, A Steinert, L Sempere, J M Gonzalez-Navajas, J Niess, R Francés
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172517/p420-anti-tnf-for-post-operative-prevention-in-crohn-s-disease-the-detection-of-anti-drug-antibodies-at-time-of-surgery-is-associated-with-an-increased-risk-of-endoscopic-recurrence
#20
C Auzolle, P Houze, M-L Tran-Minh, S Nancey, A Buisson, M Fumery, B Pariente, F Djenidi, P Marteau, Y Bouhnik, P Seksik, M Allez
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
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