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Intestinal metaplasia

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https://www.readbyqxmd.com/read/29666402/expression-of-kk-lc-1-a-cancer-testis-antigen-at-non-tumour-sites-of-the-stomach-carrying-a-tumour
#1
Takashi Fukuyama, Nobue Futawatari, Rui Yamamura, Taiga Yamazaki, Yoshinobu Ichiki, Akira Ema, Hideki Ushiku, Yatsushi Nishi, Yoshihito Takahashi, Toshikazu Otsuka, Hitoshi Yamazaki, Wasaburo Koizumi, Kosei Yasumoto, Noritada Kobayashi
Kita-Kyushu lung cancer antigen-1 (KK-LC-1) is a cancer/testis antigen (CTA) and predominant target for cancer immunotherapy. Our previous study indicated that KK-LC-1 was expressed in 82% of gastric cancers, and also in 79% of early stage of gastric cancers, with a correlation to Helicobacter pylori (H. pylori) infection. In addition, we found that KK-LC-1 was occasionally expressed at non-tumour sites of stomachs carrying tumours. Here, we investigated the characteristics of KK-LC-1 expression at non-tumour sites and the clinical utility of these phenomena...
April 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29663251/histopathological-findings-in-morbid-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-does-h-pylori-infection-effective-on-pathological-changes
#2
Ramazan İlyas Öner, Sabri Özdaş
AıM: To determine the prevalence of histopathological findings requiring clinical follow-up in morbidly obese patients undergoing laparoscopic sleeve gastrectomy (LSG) and evaluate the relationship between these findings and Helicobacter pylori as well as to add more data to the published literature in this regard. MATERıAL AND METHODS: Overall, 161 morbidly obese patients with body mass index (BMI) > 40 kg/m2 who underwent LSG between May 1, 2014 and May 31, 2017 were retrospectively included in the study...
April 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29656498/helicobacter-pylori-infection-induced-h3ser10-phosphorylation-in-stepwise-gastric-carcinogenesis-and-its-clinical-implications
#3
Tao-Tao Yang, Na Cao, Hai-Hui Zhang, Jian-Bo Wei, Xiao-Xia Song, Dong-Min Yi, Shuai-Heng Chao, Li-Da Zhang, Ling-Fei Kong, Shuang-Yin Han, Yu-Xiu Yang, Song-Ze Ding
BACKGROUND: Our previous works have demonstrated that Helicobacter pylori (Hp) infection can alter histone H3 serine 10 phosphorylation status in gastric epithelial cells. However, whether Helicobacter pylori-induced histone H3 serine 10 phosphorylation participates in gastric carcinogenesis is unknown. We investigate the expression of histone H3 serine 10 phosphorylation in various stages of gastric disease and explore its clinical implication. MATERIALS AND METHODS: Stomach biopsy samples from 129 patients were collected and stained with histone H3 serine 10 phosphorylation, Ki67, and Helicobacter pylori by immunohistochemistry staining, expressed as labeling index...
April 15, 2018: Helicobacter
https://www.readbyqxmd.com/read/29655833/development-of-evidence-based-surveillance-intervals-following-radiofrequency-ablation-of-barrett-s-esophagus
#4
Cary C Cotton, Rehan Haidry, Aaron P Thrift, Laurence Lovat, Nicholas J Shaheen
BACKGROUND AND AIMS: Barrett's esophagus (BE) recurs in 25% or more of patients treated successfully with radiofrequency ablation (RFA), so surveillance endoscopy is recommended after complete eradication of intestinal metaplasia (CEIM). The frequency of surveillance is informed only by expert opinion. We aimed to model the incidence of neoplastic recurrence, validate the model in an independent cohort, and propose evidence-based surveillance intervals. METHODS: We collected data from the United States Radiofrequency Ablation Registry (US RFA, 2004-2013) and the United Kingdom National Halo Registry (UK NHR, 2007-2015) to build and validate models to predict the incidence of neoplasia recurrence following initially successful RFA...
April 12, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29648578/gastric-adenocarcinoma-of-the-fundic-gland-type-update-and-literature-review
#5
Mark A Benedict, Gregory Y Lauwers, Dhanpat Jain
Objectives: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described entity with a lack of awareness amongst general surgical pathologists and this review highlights the key features and controversies associated with this uncommon neoplasm. Methods: A literature search through PubMed using synonyms for GA-FG was conducted to obtain 111 cases. Results: GA-FG is a well-differentiated neoplasm of oxyntic mucosa, that is comprised of chief cells and parietal cells...
April 10, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29626424/multifocal-nitrous-oxide-cryoballoon-ablation-with-or-without-emr-for-treatment-of-neoplastic-barrett-s-esophagus
#6
Marcia Irene Canto, Nicholas J Shaheen, Jose Alejandro Almario, Lysandra Voltaggio, Elizabeth Montgomery, Charles J Lightdale
BACKGROUND AND AIMS: Endoscopic cryotherapy can eradicate neoplastic Barrett's esophagus (BE). A new contact cryoballoon focal ablation system (CbFAS)) freezes esophageal mucosa with nitrous oxide. We studied the safety and efficacy of CbFAS for complete eradication of neoplastic Barrett's esophagus. METHODS: In a prospective clinical trial, consecutive BE patients with confirmed neoplasia (low-grade dysplasia LGD, high-grade dysplasia HGD, and/or intramucosal adenocarcinoma ImCA), at least 1 cm of BE, with or without prior ablation, were treated with a dose 10 seconds of spray per site...
April 4, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29625925/pancreatic-and-gastric-heterotopic-tissue-presenting-as-a-symptomatic-gallbladder-mass-a-case-report-and-literature-review
#7
M Kantor, S Eiseler, J Lai, X Liu, S Hughes, A Schiller
Pancreatic and gastric heterotopia is an uncommon congenital anomaly in which gastric and/or pancreatic tissue is found outside of its anatomic location. In the majority of patients, lesions are found incidentally because they tend to be asymptomatic. However, lesions may become symptomatic when inflammation, obstruction, and bleeding occurs. Depending on tissue size and location they can harvest a landscape of nonspecific symptoms, causing a delay in diagnosis. Heterotopic tissue of either gastric or pancreatic origin have been reported in literature, however the presence of combined gastric and pancreatic heterotopic tissue is exceedingly rare...
April 3, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29616129/line-1-hypomethylation-is-inversely-correlated-with-uhrf1-overexpression-in-gastric-cancer
#8
Jang Hee Hong, Eun-Heui Jin, Soyeon Kim, Kyu-Sang Song, Jae Kyu Sung
DNA methylation is an important epigenetic modification that alters gene expression; DNA hypomethylation contributes to tumorigenesis through multiple processes. In the present study, the methylation of long interspersed element-1 (LINE-1) in 95 gastric cancer (GC) tissues and matched adjacent normal tissues was investigated by pyrosequencing. LINE-1 methylation was compared with the expression of ubiquitin-like with PHD and ring-finger protein 1 (UHRF1), an essential regulator of DNA methylation, using reverse transcription-quantitative polymerase chain reaction...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29606921/overview-of-current-concepts-in-gastric-intestinal-metaplasia-and-gastric-cancer
#9
David S Jencks, Jason D Adam, Marie L Borum, Joyce M Koh, Sindu Stephen, David B Doman
Gastric intestinal metaplasia is a precancerous change of the mucosa of the stomach with intestinal epithelium, and is associated with an increased risk of dysplasia and cancer. The pathogenesis to gastric cancer is proposed by the Correa hypothesis as the transition from normal gastric epithelium to invasive cancer via inflammation followed by intramucosal cancer and invasion. Multiple risk factors have been associated with the development of gastric intestinal metaplasia interplay, including Helicobacter pylori infection and associated genomics, host genetic factors, environmental milieu, rheumatologic disorders, diet, and intestinal microbiota...
February 2018: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29599357/gastric-cancer-of-crawling-type-detected-by-additional-gastrectomy-after-endoscopic-submucosal-resection
#10
Yasuhiro Haruta, Ryota Nakanishi, Tomoko Jogo, Yuichiro Nakashima, Hiroshi Saeki, Eiji Oki, Minako Fujiwara, Yoshinao Oda, Yoshihiko Maehara
"Crawling type" gastric cancer (GC) is known as a rare variant of early GCs, which is difficult to diagnose at an early stage because of low-grade nuclear atypia and a morphology mimicking intestinal metaplasia. This is a case report of a 69-year-old woman who was diagnosed with early-stage gastric cancer. She had endoscopic submucosal resection (ESD) and histologically, both horizontal and vertical margins were negative. Seven months after ESD, a new lesion of the stomach was detected by follow-up gastroscopy...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29596454/classification-of-atrophic-mucosal-patterns-on-blue-laser-imaging-for-endoscopic-diagnosis-of-helicobacter-pylori-related-gastritis-a-retrospective-observational-study
#11
Yoshiyuki Nishikawa, Yoshio Ikeda, Hidehiro Murakami, Shin-Ichiro Hori, Kaori Hino, Chise Sasaki, Megumi Nishikawa
BACKGROUND: Atrophic gastritis can be classified according to characteristic mucosal patterns observed by Blue LASER Imaging (BLI) in a medium-range to distant view. AIMS: To facilitate the endoscopic diagnosis of Helicobacter pylori (HP)-related gastritis, we investigated whether atrophic mucosal patterns correlated with HP infection based on the image interpretations of three endoscopists blinded to clinical features. METHODS: This study included 441 patients diagnosed as having atrophic gastritis by upper gastrointestinal endoscopy at Nishikawa Gastrointestinal Clinic between April 1, 2015 and March 31, 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29573173/chinese-consensus-on-chronic-gastritis-2017-shanghai
#12
Jing-Yuan Fang
Since the Chinese Consensus on Chronic Gastritis1 was established at the National Chronic Gastritis Symposium in Shanghai in November 2012, the Kyoto global consensus report on Helicobacter pylori gastritis2 (hereinafter referred to as the Kyoto consensus), which emphasizes both the role of Helicobacter pylori (H. pylori) and the classification and staging system for chronic gastritis based on the operative link for gastritis assessment (OLGA)3,4 and even the operative link for gastric intestinal metaplasia assessment (OLGIM), was internationally promulgated, as well as the ABC classification, the Maastricht V consensus,5 and the fifth Chinese national consensus report on management of Helicobacter pylori infection6 ...
March 23, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29555575/acot1-expression-is-associated-with-poor-prognosis-in-gastric-adenocarcinoma
#13
Fang Wang, Jingyi Wu, Zhichao Qiu, Xiaosong Ge, Xingxiang Liu, Chun Zhang, Wenhuan Xu, Fengming Wang, Dong Hua, Xiaowei Qi, Yong Mao
Acyl-CoA thioesterase 1 (ACOT1) is an important isoform of the ACOT family that catalyzes the reaction of fatty acyl-CoAs to CoA-SH and free fatty acids. Recent studies of gastrointestinal tumor metabolism suggest that there is abnormal metabolism of lipids and fatty acids during tumor progression. However, the function and contribution of ACOT1 in gastric cancer development are still poorly understood. Additionally, GLI3 is a major transcription factor in the regulation of hedgehog (Hh) signaling. GLI3 mutations induce glandular expansion and intestinal metaplasia in gastric cancer, which indicates a role for GLI3 in the preneoplastic process...
March 16, 2018: Human Pathology
https://www.readbyqxmd.com/read/29552386/spectrum-and-time-resolved-endogenous-multiphoton-signals-reveal-quantitative-differentiation-of-premalignant-and-malignant-gastric-mucosa
#14
Xi Li, Hui Li, Xingzhen He, Tingai Chen, Xianyuan Xia, Chunxia Yang, Wei Zheng
Early identification of premalignant and malignant gastric mucosa is crucial to decrease the incidence and mortality of stomach cancer. Spectrum- and time-resolved multiphoton microscopy are capable of providing not only structural but also biochemical information at the subcellular level. Based on this multidimensional imaging technique, we performed a systematic investigation on fresh human tissue specimens at the typical stages of gastric carcinogenesis, including normal, chronic gastritis with erosion, chronic gastritis with intestinal metaplasia, and intestinal-type adenocarcinoma...
February 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29543676/phyllodes-tumor-of-the-prostate-with-epithelial-intestinal-metaplasia
#15
Andrea D Olivas, Jerome Taxy, Rebecca Wolsky, Tatjana Antic
Phyllodes tumor of the prostate is a rare mesenchymal tumor conventionally regarded as a stromal tumor of undetermined malignant potential. While the initial presentation is that of urinary obstruction and/or hematuria, the subsequent clinical behavior is thought to be a function of stromal cellularity and cytologic changes of malignancy. Of histologic interest, the epithelial component of this tumor varies, including intestinal metaplasia, as seen in the present case.
March 14, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29542263/how-are-the-expression-patterns-of-gut-antimicrobial-peptides-modulated-by-human-gastrointestinal-diseases-a-bridge-between-infectious-inflammatory-and-malignant-diseases
#16
REVIEW
Paulo André Dias Bastos, Lúcio Lara Santos, Rui Miguel Pinheiro Vitorino
The human gut barrier is the tissue exposed to the highest load of microorganisms, harbouring 100 trillion bacteria. In addition, the gut's renewal rate outruns that of any other human tissue. Antimicrobial peptides (AMPs) are highly optimized defense molecules in the intestinal barrier optimized to maintain gastrointestinal homeostasis. Alterations in AMPs activity can lead to or result from human gastrointestinal diseases. In this review, unique, conserved, or otherwise regular alterations in the expression patterns of human AMPs across gastrointestinal inflammatory and infectious diseases were analyzed for pattern elucidation...
March 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29536297/diagnostic-accuracy-of-demarcation-using-magnifying-endoscopy-with-narrow-band-imaging-for-helicobacter-pylori-uninfected-undifferentiated-type-early-gastric-cancer
#17
Yusuke Horiuchi, Junko Fujisaki, Noriko Yamamoto, Shoichi Yoshimizu, Akiyoshi Ishiyama, Toshiyuki Yoshio, Toshiaki Hirasawa, Yorimasa Yamamoto, Masatsugu Nagahama, Hiroshi Takahashi, Tomohiro Tsuchida
BACKGROUND: It is unknown how the accuracy rate of diagnostic demarcation of undifferentiated-type early gastric cancers (UD-type EGCs) differs between patients uninfected with Helicobacter pylori (H. pylori) and patients with and without H. pylori eradication. This study assessed and compared the diagnostic accuracy rate in the H. pylori-uninfected group and the non-H. pylori eradication and H. pylori eradication groups. METHODS: Subjects were 81 patients with 81 lesions who underwent endoscopic submucosal dissection between January 2010 and January 2015...
March 13, 2018: Gastric Cancer
https://www.readbyqxmd.com/read/29535809/circulating-microrna-196a-is-an-early-gastric-cancer-biomarker
#18
Tsung-Hsing Chen, Chieh Lee, Cheng-Tang Chiu, Yin-Yi Chu, Hao-Tsai Cheng, Jun-Te Hsu, Yung-Kuan Tsou, Ren-Chin Wu, Tse-Ching Chen, Nien-Chen Chang, Ta-Sen Yeh, Kwang-Huei Lin
MicroRNA-196a (miRNA-196a) is associated with the development of gastric cancer and metastasis. Intestinal metaplasia and low- or high-grade dysplasia are considered to be precursors of intestinal type gastric cancer. Accordingly, we investigated the expression of plasma miRNA-196a as an early detection biomarker in precancerous gastric lesions and early cancer (pT1a/b), which is otherwise treated with endoscopic submucosal dissection. Our data showed that levels of circulating (plasma) miRNA-196a were higher in patients with precancerous lesions/early gastric adenocarcinoma than in healthy controls...
February 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29529279/nonclinical-safety-assessment-of-the-%C3%AE-secretase-inhibitor-avagacestat
#19
Frank J Simutis, Thomas P Sanderson, Gary D Pilcher, Michael J Graziano
The toxicity of avagacestat, a sulfonamide-based gamma (γ)-secretase inhibitor that was in development as a treatment for Alzheimer's disease, was evaluated in a comprehensive nonclinical toxicology program that included 6-month and 1-year repeat-dose toxicity studies in rats and dogs, respectively. There was a spectrum of mechanism-based changes attributed to inhibition of Notch signaling that regulates the differentiation and proliferation of cells throughout development and in adult tissues. In both rats and dogs, ovarian follicular degeneration and atrophy and a low incidence of granulosa cell hyperplasia and benign granulosa-thecal cell tumors were observed...
February 24, 2018: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29526386/systematic-alphanumeric-coded-endoscopy-versus-chromoendoscopy-for-the-detection-of-precancerous-gastric-lesions-and-early-gastric-cancer-in-subjects-at-average-risk-for-gastric-cancer
#20
A Pérez-Mendoza, Á M Zárate-Guzmán, E S Galvis García, S Sobrino Cossío, J Djamus Birch
INTRODUCTION AND AIMS: Gastric cancer is one of the main causes of cancer worldwide, but there is currently no global screening strategy for the disease. Endoscopy is the screening method of choice in some Asian countries, but no standardized technique has been recognized. Systematic alphanumeric-coded endoscopy can increase gastric lesion detection. The aim of the present article was to compare the usefulness of systematic alphanumeric-coded endoscopy with conventional endoscopy for the detection of premalignant lesions and early gastric cancer in subjects at average risk for gastric cancer...
March 8, 2018: Revista de Gastroenterología de México
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