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Intestinal metaplasia

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https://www.readbyqxmd.com/read/29453233/distinct-chemopreventive-effects-of-aspirin-in-diffuse-and-intestinal-type-gastric-cancer
#1
Ryota Niikura, Yoku Hayakawa, Yoshihiro Hirata, Mitsuru Konishi, Nobumi Suzuki, Sozaburo Ihara, Atsuo Yamada, Tetsuo Ushiku, Mitsuhiro Fujishiro, Masashi Fukayama, Kazuhiko Koike
INTRODUCTION: Although aspirin/NSAIDs may have potential preventive effects on several cancers, it remains unclear on gastric cancer. The purpose of this study was to compare the risk of developing gastric cancer and the histological changes of intestinal metaplasia and neutrophil infiltration, between aspirin/NSAIDs users and non-users. METHODS: Using an electronic endoscopy database in two hospitals from 1996 to 2017, we analyzed the data from patients with chronic gastritis who received aspirin or NSAIDs prior to upper gastrointestinal endoscopy...
February 16, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29449092/efficacy-of-narrow-band-imaging-for-detecting-intestinal-metaplasia-in-adult-patients-with-symptoms-of-dyspepsia
#2
S Sobrino-Cossío, J M Abdo Francis, F Emura, E S Galvis-García, M L Márquez Rocha, G Mateos-Pérez, C B González-Sánchez, N Uedo
INTRODUCTION AND OBJECTIVE: Atrophy and intestinal metaplasia are early phenotypic markers in gastric carcinogenesis. White light endoscopy does not allow direct biopsy of intestinal metaplasia due to a lack of contrast of the mucosa. Narrow-band imaging is known to enhance the visibility of intestinal metaplasia, to reduce sampling error, and to increase the diagnostic yield of endoscopy for intestinal metaplasia in Asian patients. The aim of our study was to validate the diagnostic performance of narrow-band imaging using 1...
February 12, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29427515/injury-repair-inflammation-and-metaplasia-in-the-stomach
#3
Anne R Meyer, James R Goldenring
The development of intestinal-type gastric cancer is preceded by the emergence of metaplastic cell lineages in the gastric mucosa. In particular, intestinal metaplasia and spasmolytic polypeptide-expressing metaplasia (SPEM) have been associated with the pathological progression to intestinal-type gastric cancer. The development of SPEM represents a physiological response to damage that recruits reparative cells to sites of mucosal injury. Metaplastic cell lineages are characterized by mucus secretion, adding a protective barrier to the epithelium...
February 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29417867/bioinformatic-analyses-of-microrna-targeted-genes-and-microarray-identified-genes-correlated-with-barrett-s-esophagus
#4
Jing Lv, Jijun Liu, Lei Guo, Jun Zhang, Yan Cheng, Chu Chen, Heping Zhao, Jihan Wang
Barrett's esophagus (BE) is defined as a metaplasia condition in the distal esophagus, in which the native squamous epithelium lining is replaced by a columnar epithelium with or without intestinal metaplasia. It is commonly accepted that BE is a precancerous lesion for esophageal adenocarcinoma. The aim of this study was to investigate the aberrant microRNAs (miRNAs) and differentially expressed genes (DEGs) associated with BE based on online microarray datasets. One miRNA and five gene expression profiling datasets were retrieved from the Gene Expression Omnibus Database...
February 8, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29403459/-helicobacter-pylori-and-gastric-cancer-adaptive-cellular-mechanisms-involved-in-disease-progression
#5
REVIEW
Paula Díaz, Manuel Valenzuela Valderrama, Jimena Bravo, Andrew F G Quest
Helicobacter pylori ( H. pylori ) infection is the major risk factor associated with the development of gastric cancer. The transition from normal mucosa to non-atrophic gastritis, triggered primarily by H. pylori infection, initiates precancerous lesions which may then progress to atrophic gastritis and intestinal metaplasia. Further progression to dysplasia and gastric cancer is generally believed to be attributable to processes that no longer require the presence of H. pylori . The responses that develop upon H...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29399610/deep-learning-analyzes-helicobacter-pylori-infection-by-upper-gastrointestinal-endoscopy-images
#6
Takumi Itoh, Hiroshi Kawahira, Hirotaka Nakashima, Noriko Yata
Background and study aims : Helicobacter pylori (HP)-associated chronic gastritis can cause mucosal atrophy and intestinal metaplasia, both of which increase the risk of gastric cancer. The accurate diagnosis of HP infection during routine medical checks is important. We aimed to develop a convolutional neural network (CNN), which is a machine-learning algorithm similar to deep learning, capable of recognizing specific features of gastric endoscopy images. The goal behind developing such a system was to detect HP infection early, thus preventing gastric cancer...
February 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29373557/autoimmunity-and-gastric-cancer
#7
REVIEW
Nicola Bizzaro, Antonio Antico, Danilo Villalta
Alterations in the immune response of patients with autoimmune diseases may predispose to malignancies, and a link between chronic autoimmune gastritis and gastric cancer has been reported in many studies. Intestinal metaplasia with dysplasia of the gastric corpus-fundus mucosa and hyperplasia of chromaffin cells, which are typical features of late-stage autoimmune gastritis, are considered precursor lesions. Autoimmune gastritis has been associated with the development of two types of gastric neoplasms: intestinal type and type I gastric carcinoid...
January 26, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29369216/helicobacter-pylori-eradication-may-influence-timing-of-endoscopic-surveillance-for-gastric-cancer-in-patients-with-gastric-precancerous-lesions-a-retrospective-study
#8
Maria Pina Dore, Alice Cipolli, Matteo Walter Ruggiu, Alessandra Manca, Gabrio Bassotti, Giovanni Mario Pes
Chronic atrophic gastritis and intestinal metaplasia related to Helicobacter pylori infection, are major risk factors for gastric adenocarcinoma. Eradication of H pylori and endoscopy surveillance of precancerous lesions may reduce the risk and/or lead to early detection of gastric cancer improving survival. In this study, the progression of precancerous lesions after H pylori treatment was evaluated.Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29350665/laparoscopic-gastric-bypass-with-remnant-gastrectomy-in-a-super-super-obese-patient-with-gastric-metaplasia-a-surgical-hazard
#9
Francesco Tartamella, Gabriele Petracca, Andrea Romboli, Federico Marchesi
The endoscopic inaccessibility of the gastric remnant after Roux-en-Y gastric bypass (RYGBP) for morbid obesity represents an important issue for patients with familiar history of gastric cancer (GC) or affected by premalignant lesions, such as intestinal metaplasia. If a different bariatric procedure is contraindicated, RYGBP with remnant gastrectomy represents a reasonable alternative, significantly reducing the risk of GC but potentially increasing postoperative morbidity. For this reason, only few cases have been reported in the recent Literature and none regarding a super-super obese patient...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29345968/mature-gastric-chief-cells-are-not-required-for-the-development-of-metaplasia
#10
Hiroto Kinoshita, Yoku Hayakawa, Zhengchuan Niu, Mitsuru Konishi, Masahiro Hata, Mayo Tsuboi, Yuki Hayata, Yohko Hikiba, Sozaburo Ihara, Hayato Nakagawa, Yoshihiro Hirata, Timothy C Wang, K Koike
During human gastric carcinogenesis, intestinal metaplasia (IM) is frequently seen in the atrophic stomach. In mice, a distinct type of metaplasia known as spasmolytic polypeptide-expressing metaplasia (SPEM) is found in several inflammatory and genetically engineered models. Given the diversity of long- and short-term models of mouse SPEM, it remains unclear whether all models have a shared or distinct molecular mechanism. The origin of SPEM in mice is currently under debate. It is postulated that stem or progenitor cells acquire genetic alterations that then supply metaplastic cell clones, while the possibility of transdifferentiation or dedifferentiation from mature gastric chief cells has also been suggested...
January 18, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29334683/epigenetic-silencing-of-the-mlh1-promoter-in-relation-to-the-development-of-gastric-cancer-and-its-use-as-a-biomarker-for-patients-with-microsatellite-instability-a-systematic-analysis
#11
Guimei Hu, Lijun Qin, Xinjun Zhang, Guoliang Ye, Tao Huang
BACKGROUND/AIMS: Human mutL homolog 1 (MLH1) promoter methylation was reported in gastric cancer (GC). This study determined the clinicopathological, prognostic, and diagnostic effects of MLH1 promoter methylation in GC. METHODS: The combined odds ratio (OR) or hazard ratio (HR) and their corresponding 95% confidence intervals (95% CI) were calculated. The pooled sensitivity, specificity, and area under the curve (AUC) were analyzed. RESULTS: A total of 4654 GC patients and 3669 non-malignant controls were identified in this systematic analysis...
January 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29327262/risk-of-neoplastic-progression-among-patients-with-an-irregular-z-line-on-long-term-follow-up
#12
David Itskoviz, Zohar Levi, Doron Boltin, Alex Vilkin, Yifat Snir, Rachel Gingold-Belfer, Yaron Niv, Iris Dotan, Ram Dickman
BACKGROUND: Barrett's esophagus (BE) is a known complication of gastroesophageal reflux disease. In a previous study, we described a high prevalence of intestinal metaplasia (IM) in patients with an irregular Z line. However, the clinical importance of this finding is unclear. GOALS: To evaluate the long-term development of BE and relevant complications in patients diagnosed with an irregular Z line, with or without IM, on routine esophago-gastro-duodenoscopy (EGD)...
January 11, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29317709/increased-abundance-of-clostridium-and-fusobacterium-in-gastric-microbiota-of-patients-with-gastric-cancer-in-taiwan
#13
Yung-Yu Hsieh, Shui-Yi Tung, Hung-Yu Pan, Chih-Wei Yen, Huang-Wei Xu, Ying-Jhen Lin, Yi-Fang Deng, Wan-Ting Hsu, Cheng-Shyong Wu, Chin Li
Helicobacter pylori is recognised as a main risk factor for gastric cancer. However, approximately half of the patients with gastritis are negative for H. pylori infection, and the abundance of H. pylori decreases in patients with cancer. In the current study, we profiled gastric epithelium-associated bacterial species in patients with gastritis, intestinal metaplasia, and gastric cancer to identify additional potential pathogenic bacteria. The overall composition of the microbiota was similar between the patients with gastritis and those with intestinal metaplasia...
January 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29316435/molecular-predictors-of-gastric-neoplastic-progression
#14
Paul Lochhead, Emad M El-Omar
In this issue of Cancer Cell, Huang et al. describe comprehensive genetic and epigenetic profiling of gastric intestinal metaplasia lesions from a longitudinal cohort in which outcome data allowed for identification of potential markers of gastric neoplastic progression.
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29315971/levels-of-malondialdehyde-in-the-gastric-juice-its-association-with-helicobacter-pylori-infection-and-stomach-diseases
#15
Yao-Kuang Wang, Wei-Chih Chiang, Fu-Chen Kuo, Meng-Chieh Wu, Hsiang-Yao Shih, Sophie S W Wang, Chung-Jung Liu, Yen-Hsu Chen, Deng-Chyang Wu, Wei-Wen Su, Yeou-Lih Huang
BACKGROUND: Helicobacter pylori (H. pylori) infection causes elevation of lipid peroxidation product malondialdehyde (MDA) and this association may be due to the bacterium causing reactive oxygen species-mediated damage to DNA in the gastric epithelium. The aim of this study was to investigate the gastric juice MDA levels in relation to H. pylori infection and associated gastric diseases. METHODS: Gastric juice samples were obtained from 117 patients undergoing endoscopy, and gastric juice MDA levels were determined by high-performance liquid chromatography (HPLC) system...
January 5, 2018: Helicobacter
https://www.readbyqxmd.com/read/29305814/histopathology-findings-in-patients-undergoing-laparoscopic-sleeve-gastrectomy
#16
Ammiel Martínez Canil, Angelo Iossa, Pietro Termine, Daniela Caporilli, Vincenzo Petrozza, Gianfranco Silecchia
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) has gained popularity in the last 10 years for its good results in weight loss and comorbidity control. However, guidelines on the pathological examination of the specimen are lacking. The aim of this retrospective study was to determine the usefulness of the routine specimen examination when presurgery endoscopy (upper gastrointestinal endoscopy, UGIE) and multiple gastric biopsies are part of the preoperative work-up. METHODS: A retrospective review of records of the patients submitted to LSG between January 2012 and August 2017 was carried out...
January 5, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29302869/lanthanum-induced-mucosal-alterations-in-the-stomach-lanthanum-gastropathy-a-comparative-study-using-an-animal-model
#17
Kei Yabuki, Joji Haratake, Yojiro Tsuda, Eisuke Shiba, Hiroshi Harada, Kenji Yorita, Kazuyoshi Uchihashi, Atsuji Matsuyama, Keiji Hirata, Masanori Hisaoka
Lanthanum (La) carbonate (LC) is one of the most potent phosphate binders that prevents the elevation of serum phosphate levels in patients with end-stage renal diseases undergoing dialysis. LC binds strongly to dietary phosphate and forms insoluble complexes that pass through the gastrointestinal tract. La deposition in patients treated with LC is a recently documented finding particularly observed in gastric mucosa. We herein describe the detailed gastric mucosal lesions in 45 LC-treated patients and address the potential underlying pathologic mechanism using oral LC administration in rats...
January 4, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29290541/genomic-and-epigenomic-profiling-of-high-risk-intestinal-metaplasia-reveals-molecular-determinants-of-progression-to-gastric-cancer
#18
Kie Kyon Huang, Kalpana Ramnarayanan, Feng Zhu, Supriya Srivastava, Chang Xu, Angie Lay Keng Tan, Minghui Lee, Suting Tay, Kakoli Das, Manjie Xing, Aliya Fatehullah, Syed Muhammad Fahmy Alkaff, Tony Kiat Hon Lim, Jonathan Lee, Khek Yu Ho, Steven George Rozen, Bin Tean Teh, Nick Barker, Chung King Chia, Christopher Khor, Choon Jin Ooi, Kwong Ming Fock, Jimmy So, Wee Chian Lim, Khoon Lin Ling, Tiing Leong Ang, Andrew Wong, Jaideepraj Rao, Andrea Rajnakova, Lee Guan Lim, Wai Ming Yap, Ming Teh, Khay Guan Yeoh, Patrick Tan
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with increased gastric cancer (GC) risk. We performed (epi)genomic profiling of 138 IMs from 148 cancer-free patients, recruited through a 10-year prospective study. Compared with GCs, IMs exhibit low mutational burdens, recurrent mutations in certain tumor suppressors (FBXW7) but not others (TP53, ARID1A), chromosome 8q amplification, and shortened telomeres. Sequencing identified more IM patients with active Helicobacter pylori infection compared with histopathology (11%-27%)...
December 26, 2017: Cancer Cell
https://www.readbyqxmd.com/read/29273468/systematic-gastric-biopsy-in-iron-deficiency-anaemia
#19
Hela Elloumi, Meriam Sabbah, Achraf Debbiche, Asma Ouakaa, Norsaf Bibani, Dorra Trad, Dalila Gargouri, Jamel Kharrat
BACKGROUND AND STUDY AIMS: Gastric biopsies are recommended in patients with iron deficiency anaemia to identify atrophic gastritis. However, in practice, only duodenal biopsies are routinely performed. The aim of our study was to determine the value of gastric biopsies in iron deficiency anaemia. PATIENTS AND METHODS: A prospective study including all patients referred for gastrointestinal endoscopy for iron deficiency anaemia from May 2008 to September 2014 was performed...
December 19, 2017: Arab Journal of Gastroenterology: the Official Publication of the Pan-Arab Association of Gastroenterology
https://www.readbyqxmd.com/read/29273452/development-and-validation-of-a-model-to-determine-risk-of-progression-of-barrett-s-esophagus-to-neoplasia
#20
Sravanthi Parasa, Sreekar Vennalaganti, Srinivas Gaddam, Prashanth Vennalaganti, Patrick Young, Neil Gupta, Prashanthi Thota, Brooks Cash, Sharad Mathur, Richard Sampliner, Fouad Moawad, David Lieberman, Ajay Bansal, Kevin F Kennedy, John Vargo, Gary Falk, Manon Spaander, Marco Bruno, Prateek Sharma
BACKGROUND & AIMS: A system is needed to determine the risk of patients with Barrett's esophagus for progression to high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC). We developed and validated a model to determine of progression to HGD or EAC in patients with BE, based on demographic data and endoscopic and histologic findings at the time of index endoscopy. METHODS: We performed a longitudinal study of patients with BE at 5 centers in United States and 1 center in Netherlands enrolled in the Barrett's Esophagus Study database from 1985 through 2014...
December 19, 2017: Gastroenterology
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