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Intestinal metaplasia

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https://www.readbyqxmd.com/read/29225268/two-cases-of-lanthanum-deposition-in-the-stomach-in-the-absence-of-helicobacter-pylori-infection
#1
Masaya Iwamuro, Haruo Urata, Takehiro Tanaka, Seiji Kawano, Yoshiro Kawahara, Katsuhiko Kimoto, Hiroyuki Okada
In this case report, we describe two patients who showed a diffusely whitish mucosa in the posterior wall and the lesser curvature of the gastric body. The patients were serologically- and histopathologically-negative for Helicobacter pylori. Random biopsy specimens from the stomach revealed no regenerative changes, intestinal metaplasia, and/or foveolar hyperplasia in either of the patients. Although lanthanum deposition in the gastric mucosa has been reported to occur in close association with H. pylori-associated gastritis, our patients tested negative for H...
December 8, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29218319/low-yield-for-non-targeted-biopsies-of-the-stomach-and-esophagus-during-elective-esophagogastroduodenoscopy
#2
Michael K Dougherty, Phillip P Santoiemma, Andrew T Weber, David C Metz, Yu-Xiao Yang
Background and study aims:  Biopsies of non-specific mucosal findings are often performed during esophagogastroduodenoscopy (EGD). We sought to determine the prevalence and clinical utility of non-targeted biopsies of the stomach and esophagus. Patients and methods:  We conducted a retrospective review of 949 outpatient EGDs performed at a US tertiary referral center. Non-targeted biopsies of the stomach were defined as either "normal" or "mild" to "moderate" "erythema" or "inflammation" without other endoscopic features...
December 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29215765/helicobacter-pylori-induces-cdx2-and-cox2-expression-by-modulating-micrornas-in-esophageal-epithelial-cells
#3
Guigen Teng, Yun Dai, Yunxiang Chu, Jing Li, Hongchen Zhang, Ting Wu, Xiaowei Shuai, Weihong Wang
Dysregulation of microRNAs (miRNAs) has been linked to virulence factors of Helicobacter pylori (H. pylori). The role of H. pylori in esophageal disease has not been clearly defined. We previously reported that H. pylori-esophageal colonization promotes the incidence of Barrett's esophagus and esophageal adenocarcinoma in vivo. Here, we studied the direct effects of H. pylori on the transformation of esophageal epithelial cells, with particular focus on whether H. pylori exerts its effects by modulating miRNAs and their downstream target genes...
December 7, 2017: Cancer Science
https://www.readbyqxmd.com/read/29212456/helicobacter-induced-gastric-inflammation-alters-the-properties-of-gastric-tissue-stem-progenitor-cells
#4
Wataru Shibata, Soichiro Sue, Sachiko Tsumura, Yasuaki Ishii, Takeshi Sato, Eri Kameta, Makoto Sugimori, Hiroaki Yamada, Hiroaki Kaneko, Tomohiko Sasaki, Tomohiro Ishii, Toshihide Tamura, Masaaki Kondo, Shin Maeda
BACKGROUND: Although Helicobacter-induced gastric inflammation is the major predisposing factor for gastric carcinogenesis, the precise mechanism by which chronic gastritis causes gastric cancer remains unclear. Intestinal and spasmolytic polypeptide-expressing metaplasia (SPEM) is considered as precancerous lesions, changes in epithelial tissue stem/progenitor cells after chronic inflammation has not been clarified yet. In this study, we utilized three-dimensional gastric epithelial cell culture systems that could form organoids, mimicking gastric epithelial layer, and characterized the changes in epithelial cells after chronic Helicobacter felis infection...
December 6, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29211875/the-safety-and-efficacy-of-radiofrequency-ablation-following-endoscopic-submucosal-dissection-for-barrett-s-neoplasia
#5
S Subramaniam, K Kandiah, F Chedgy, P Meredith, G Longcroft-Wheaton, P Bhandari
The current standard of treating early Barrett's neoplasia is resection of visible lesions using endoscopic mucosal resection (EMR) followed by ablative therapy to the Barrett's segment. There is increasing evidence to support the use of endoscopic submucosal dissection (ESD) where en-bloc resection and lower recurrence rates may be achieved. However, ESD is associated with deep submucosal dissection when compared to EMR. This may increase the risk of complications including stricture formation with subsequent radiofrequency ablation (RFA) therapy...
December 2, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29209116/gastric-xanthelasma-and-metabolic-disorders-a-large-retrospective-study-among-chinese-population
#6
Yi Chen, Xin-Jue He, Min-Jian Zhou, You-Ming Li
AIM: To gain knowledge of xanthelasma, a large population-based study was conducted. METHODS: Patients who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China during Jan 2009 to Nov 2016 were included. General characteristics as well as clinical data were collected, including blood routine, serum biochemical analysis, endoscopic findinds, histological evaluation and comorbiditie. Statistical analyses was performed using SPSS 20...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29209106/noncoding-rnas-as-drivers-of-the-phenotypic-plasticity-of-oesophageal-mucosa
#7
EDITORIAL
Matteo Fassan, Sonia Facchin, Giada Munari, Giuseppe Nicolò Fanelli, Greta Lorenzon, Edoardo Savarino
The histological commitment of the lower oesophageal mucosa largely depends on a complex molecular landscape. After extended inflammatory insult due to gastroesophageal reflux disease, squamous oesophageal mucosa may differentiate into columnar metaplastic mucosa. In this setting, the presence of intestinal metaplasia is considered the starting point of Barrett's carcinogenetic cascade. Aside from secondary prevention strategies for Barrett's mucosa (BM) patients, there are multiple endoscopic ablative therapies available for BM eradication and for the replacement of metaplastic epithelia with a neosquamous mucosa...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29199171/gastroesophageal-reflux-disease-and-the-relationship-with-helicobacter-pylori
#8
Zeynel Mungan, Binnur Pınarbaşı Şimşek
After Helicobacter pylori was identified, and its relationship with peptic ulcer disease was exactly shown, the relationship of this bacterium with gastroesophageal reflux disease (GERD) gained momentum and discussions continue to this day. We reviewed the literature for the relationship between H. pylori and GERD. According to the existing data, there is no relationship between GERD and H. pylori presence. Successful eradication therapy does not have an impact on the emergence or exacerbation of GERD. However Barrett's esophagus and esophageal adenocarcinoma are less frequent, especially in the presence of CagA positive H...
December 2017: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29193217/reversibility-of-atrophic-gastritis-and-intestinal-metaplasia-after-helicobacter-pylori-eradication-a-prospective-study-for-up-to-10-years
#9
Y-J Hwang, N Kim, H S Lee, J B Lee, Y J Choi, H Yoon, C M Shin, Y S Park, D H Lee
BACKGROUND: Atrophic gastritis and intestinal metaplasia are premalignant conditions for gastric cancer. Their reversibility by Helicobacter pylori eradication remains controversial. AIM: To evaluate the reversibility of atrophic gastritis and intestinal metaplasia by H. pylori eradication with long-term follow-up. METHODS: 598 subjects were prospectively enrolled and followed for up to 10 years. They were categorised as H. pylori-negative (n = 65), H...
November 29, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29181158/serum-pepsinogen-and-gastrin-17-as-potential-biomarkers-for-pre-malignant-lesions-in-the-gastric-corpus
#10
Tan Han Loong, Ngiu Chai Soon, Nik Ritza Kosai Nik Mahmud, Jeevinesh Naidu, Rafiz Abdul Rani, Nazefah Abdul Hamid, Marjanu Hikmah Elias, Isa Mohamed Rose, Azmi Tamil, Norfilza M Mokhtar, Raja Affendi Raja Ali
There is a lack of non-invasive screening modalities to diagnose chronic atrophic gastritis (CAG) and intestinal metaplasia (IM). Thus, the aim of the present study was to determine the sensitivity and specificity of serum pepsinogen I (PGI), PGI:II, the PGI:II ratio and gastrin-17 (G-17) in diagnosing CAG and IM, and the correlations between these serum biomarkers and pre-malignant gastric lesions. A cross-sectional study of 72 patients (82% of the calculated sample size) who underwent oesophageal-gastro-duodenoscopy for dyspepsia was performed in the present study...
November 2017: Biomedical Reports
https://www.readbyqxmd.com/read/29179204/clinical-significance-of-myeloid-zinc-finger-1-expression-in-the-progression-of-gastric-tumourigenesis
#11
Guo-Qiang Li, Qing He, Lang Yang, Shu-Bin Wang, De-Dong Yu, Yu-Qi He, Jiang Hu, Yuan-Ming Pan, Yun Wu
BACKGROUND/AIMS: To investigate the clinical significance of myeloid zinc finger 1 (MZF1) expression in various gastric mucosal lesions including chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), intestinal metaplasia (IM), dysplasia (DYS) and gastric cancer (GC) in comparison with normal tissues and gastric cell lines. METHODS: MZF1 protein expression was detected using immunohistochemical staining in 37 CSG, 88 CAG, 77 IM, 51 DYS, 165 GC and 8 normal tissue samples...
November 28, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29161901/long-term-outcomes-of-the-randomized-controlled-trial-comparing-5-aminolaevulinic-acid-and-photofrin-photodynamic-therapy-for-barrett-s-oesophagus-related-neoplasia
#12
Darina Kohoutova, Rehan Haidry, Matthew Banks, Mohammed Adil Butt, Jason Dunn, Sally Thorpe, Laurence Lovat
OBJECTIVE: Photodynamic therapy (PDT) was used as therapy for early neoplasia associated with Barrett's oesophagus (BE). This is 5-year follow-up of patients enrolled into randomised controlled trial of 5-aminolaevulinic acid (ALA) vs. Photofrin PDT. METHODS: Biopsies were taken from original Barrett's segment during endoscopic follow up using Seattle protocol. Endoscopic mucosal resection (EMR) ± radiofrequency ablation (RFA) was preferred therapy in patients who failed PDT and/or had recurrent neoplasia...
November 21, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29161756/factors-to-improve-the-interobserver-agreement-for-gastric-atrophy-and-intestinal-metaplasia-consensus-of-definition-and-criteria
#13
Sung Sun Kim, Myeong-Cherl Kook, Ok-Ran Shin, Hee Sung Kim, Han-Ik Bae, Anna Seo, Do Youn Park, Il Ju Choi, Young-Il Kim, Byung Ho Nam, Sohee Kim
AIMS: Intestinal metaplasia and atrophy of the gastric mucosa are associated with Helicobacter pylori infection and are considered premalignant lesions. The updated Sydney system is used to these parameters but experienced pathologists and consensus processes are required for interobserver agreement. We sought to determine the influence of consensus process on assessment of intestinal metaplasia and atrophy. METHODS AND RESULTS: Two study sets were used; consensus set and validation set...
November 21, 2017: Histopathology
https://www.readbyqxmd.com/read/29161426/family-history-of-gastric-mucosal-abnormality-and-the-risk-of-gastric-cancer-a-population-based-observational-study
#14
Huan Song, Isabella Guncha Ekheden, Alexander Ploner, Jan Ericsson, Olof Nyren, Weimin Ye
Background: An increased prevalence of gastric premalignant abnormalities was reported among relatives of gastric cancer (GC) patients, with rather unexplored clinical significance. Methods: In Swedish computerized pathology registers, we identified, as 'index' persons 232 681 patients who were born after 1931 and underwent endoscopic examination with stomach biopsy between 1979 and 2014. Through linkage with the Multi-Generation Register, we compiled a cohort consisting of 903 337 first-degree relatives of these biopsied patients...
November 17, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29159276/linked-color-imaging-lci-a-novel-image-enhanced-endoscopy-technology-emphasizes-the-color-of-early-gastric-cancer
#15
Hiromitsu Kanzaki, Ryuta Takenaka, Yoshiro Kawahara, Daisuke Kawai, Yuka Obayashi, Yuki Baba, Hiroyuki Sakae, Tatsuhiro Gotoda, Yoshiyasu Kono, Ko Miura, Masaya Iwamuro, Seiji Kawano, Takehiro Tanaka, Hiroyuki Okada
Background and study aims:  Linked color imaging (LCI) and blue laser imaging (BLI) are novel image-enhanced endoscopy technologies with strong, unique color enhancement. We investigated the efficacy of LCI and BLI-bright compared to conventional white light imaging (WLI) by measuring the color difference between early gastric cancer lesions and the surrounding mucosa. Patients and methods:  Images of early gastric cancer scheduled for endoscopic submucosal dissection were captured by LCI, BLI-bright, and WLI under the same conditions...
October 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29155519/quantitative-changes-of-gastric-mucosa-during-carcinogenesis-using-stereological-methods
#16
Zahra Heidari, Hamidreza Mahmoudzadeh-Sagheb, Mahdieh Narouei
PURPOSE: To investigate the effects of helicobacter pylori (H. pylori) infection on the quantitative changes of gastric mucosa in cancerous and precancerous lesions using stereological methods. METHODS: One hundred and twenty-two gastric samples were studied. After determination of H. pylori infection, 42 gastric tissues of intestinal metaplasia (IM) patients, 38 specimens from dysplasia (DYS), and 42 specimens from gastric cancer (GC) types were selected from the pathology archive of Imam Ali Hospital, Zahedan, Iran...
July 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29155082/association-of-gastric-intestinal-metaplasia-and-east-asian-ethnicity-with-the-risk-of-gastric-adenocarcinoma-in-a-u-s-population
#17
Alyssa Y Choi, Lisa L Strate, Matthew C Fix, Rodney A Schmidt, Alexander R Ende, Matthew M Yeh, John M Inadomi, Joo Ha Hwang
BACKGROUND AND AIMS: Although the incidence of gastric cancer is higher than esophageal cancer in the United States, no screening or surveillance guidelines exist. The aim of this study is to evaluate the association between gastric intestinal metaplasia and the risk of gastric cancer in a U.S. tertiary care system with a large immigrant population. METHODS: This is a retrospective case-control study with cases of biopsy-proven gastric cancer matched (by age and gender) to controls without gastric cancer who had undergone EGD...
November 16, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29154808/genetic-host-factors-in-helicobacter-pylori-induced-carcinogenesis-emerging-new-paradigms
#18
REVIEW
Michiel C Mommersteeg, Jun Yu, Maikel P Peppelenbosch, Gwenny M Fuhler
Helicobacter Pylori is a gram negative rod shaped microaerophilic bacterium that colonizes the stomach of approximately half the world's population. Infection with c may cause chronic gastritis which via a quite well described process known as Correas cascade can progress through sequential development of atrophic gastritis, intestinal metaplasia and dysplasia to gastric cancer. H. pylori is currently the only bacterium that is classified as a class 1 carcinogen by the WHO, although the exact mechanisms by which this bacterium contributes to gastric carcinogenesis are still poorly understood...
November 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29151240/rare-entities-of-histopathological-findings-in-755-sleeve-gastrectomy-cases-a-synopsis-of-preoperative-endoscopy-findings-and-histological-evaluation-of-the-specimen
#19
Erkan Yardimci, Suleyman Bozkurt, Lutfullah Baskoy, Huseyin Kazim Bektasoglu, Melin Ozgun Gecer, Samet Yigman, Huseyin Akbulut, Halil Coskun
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is the most preferred technique in morbidly obese patients for weight loss. There is a controversy about the routine preoperative evaluation of the stomach and the routine microscopic examination of all LSG specimens. Our aim is to analyze the results of both preoperative upper gastrointestinal endoscopy and endoscopic biopsies and also the results of histopathological examination of LSG specimens. MATERIALS AND METHODS: The data of patients who underwent LSG from January 2011 to November 2016 were analyzed retrospectively from a prospectively collected database...
November 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29138645/chinese-classical-formula-sijunzi-decoction-and-chronic-atrophic-gastritis-evidence-for-treatment-approach
#20
REVIEW
Danan Gan, Aili Xu, Hongbo Du, Yong'an Ye
Objective: This aim is to evaluate the effect of Sijunzi decoction (SJZD) treating chronic atrophic gastritis (CAG). Methods: We performed searches in seven databases. The randomized controlled trials (RCTs) comparing SJZD with standard medical care or inactive intervention for CAG were enrolled. Combined therapy of SJZD plus conventional therapies compared with conventional therapies alone was also retrieved. The primary outcome included the incidence of gastric cancer and the improvement of atrophy, intestinal metaplasia, and dysplasia based on the gastroscopy and pathology...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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