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https://www.readbyqxmd.com/read/29056848/syntheses-and-pdt-activity-of-new-mono-and-di-conjugated-derivatives-of-chlorin-e6
#1
Hui Chen, Stewart W Humble, R G Waruna Jinadasa, Zehua Zhou, Alex L Nguyen, M Graça H Vicente, Kevin M Smith
Syntheses of three new chlorin e6 conjugates for PDT of tumors are reported. One of the new compounds 17 is conjugated with lysine at the 13(1)-position, but the others are mono-conjugated 14 or diconjugated 15 with the non-amino acid species ethanolamine. Cellular experiments with the three new compounds and previously synthesized non-amino acid 15(2)-conjugates (7-10), 13(1)-monoconjugates 14, 16, and a 13(1),15(2)-diconjugate 12 are reported. In vitro cytotoxicity experiments show that the 13(1)-conjugates are more toxic than the 15(2)-conjugates, and the most toxic derivative (dark- and photo-toxicity) is the 13(1)-ethylenediamine conjugate 11...
April 2017: Journal of Porphyrins and Phthalocyanines
https://www.readbyqxmd.com/read/28994471/god-of-the-hinge-treating-lgbtqia-patients
#2
Annie Boland
This paper looks at systems of gender within the context of analysis. It explores the unique challenges of individuation faced by transsexual, transgender, gender queer, gender non-conforming, cross-dressing and intersex patients. To receive patients generously we need to learn how a binary culture produces profound and chronic trauma. These patients wrestle with being who they are whilst simultaneously receiving negative projections and feeling invisible. While often presenting with the struggles of gender conforming individuals, understanding the specifically gendered aspect of their identity is imperative...
November 2017: Journal of Analytical Psychology
https://www.readbyqxmd.com/read/28987153/shaping-the-dental-team-of-the-future
#3
Stephen Lambert Humble
No abstract text is available yet for this article.
August 31, 2017: Primary Dental Journal
https://www.readbyqxmd.com/read/28970458/current-status-and-future-suggestions-for-improving-the-pharm-d-curriculum-towards-clinical-pharmacy-practice-in-pakistan
#4
Saima Mahmood Malhi, Hassan Raza, Kiran Ajmal, Sumbul Shamim, Saniya Ata, Salman Farooq, Syed Muhammad Sharib, Sidrat-Ul Muntaha
Objectives & Background: Good curriculum is reflected as the backbone for standard universities to develop competitive professionals having great potential. Pharmacy education in Pakistan has gone through the same developmental stages as in other countries, but is still striving for improvement. In the present study, we want (i) to know the opinion on whether the current pharmacy curriculum requires any improvement in order to meet the training needs of pharmacy professionals regarding clinical knowledge and pharmacy practice; and (ii) to present some humble suggestions to decision-making authorities in order to improve it with respect to patient-focused programs (PFP)...
August 17, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28961978/cold-tolerance-of-mountain-pine-beetle-coleoptera-curculionidae-eggs-from-the-historic-and-expanded-ranges
#5
K P Bleiker, G D Smith, L M Humble
Winter mortality is expected to be a key factor determining the ability of mountain pine beetle, Dendroctonus ponderosae Hopkins (Coleoptera: Curculionidae), to expand its range in Canada. We determined the mortality rate and supercooling points of eggs from the beetle's historic range in southern British Columbia as well as the recently expanded range in north-central Alberta and tested if eggs require an extended period of chilling to reach their maximum cold tolerance. We found no effect of population source or acclimation time on egg cold tolerance...
July 26, 2017: Environmental Entomology
https://www.readbyqxmd.com/read/28959454/generalised-joint-hypermobility-and-neurodevelopmental-traits-in-a-non-clinical-adult-population
#6
Martin Glans, Susanne Bejerot, Mats B Humble
BACKGROUND: Generalised joint hypermobility (GJH) is reportedly overrepresented among clinical cases of attention deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and developmental coordination disorder (DCD). It is unknown if these associations are dimensional and, therefore, also relevant among non-clinical populations. AIMS: To investigate if GJH correlates with sub-syndromal neurodevelopmental symptoms in a normal population. METHOD: Hakim-Grahame's 5-part questionnaire (5PQ) on GJH, neuropsychiatric screening scales measuring ADHD and ASD traits, and a DCD-related question concerning clumsiness were distributed to a non-clinical, adult, Swedish population (n=1039)...
September 2017: BJPsych Open
https://www.readbyqxmd.com/read/28916260/primary-facial-reanimation-in-head-and-neck-cancer
#7
REVIEW
Axel Sahovaler, David Yeh, John Yoo
Facial Paralysis (FP) profoundly impairs the life of individuals, both functionally and psychosocially. Surgical approaches to treat this condition are myriad, but the ultimate goal is to restore symmetry and movement. Ablative surgery for tumors of the head and neck region are amongst the most common etiologies causing FP and this group of patients represents unique challenges. Surgical defects may have multiple competing reconstructive requirements and addressing the FP must be considered in this context...
September 12, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28891433/innate-lymphoid-cells-mediate-pulmonary-eosinophilic-inflammation-airway-mucous-cell-metaplasia-and-type-2-immunity-in-mice-exposed-to-ozone
#8
Kazuyoshi Kumagai, Ryan P Lewandowski, Daven N Jackson-Humbles, Nicholas Buglak, Ning Li, Kaylin White, Steven J Van Dyken, James G Wagner, Jack R Harkema
Exposure to elevated levels of ambient ozone in photochemical smog is associated with eosinophilic airway inflammation and nonatopic asthma in children. In the present study, we determined the role of innate lymphoid cells (ILCs) in the pathogenesis of ozone-induced nonatopic asthma by using lymphoid cell-sufficient C57BL/6 mice, ILC-sufficient Rag2(-/-) mice (devoid of T and B cells), and ILC-deficient Rag2(-/-)Il2rg(-/-) mice (depleted of all lymphoid cells including ILCs). Mice were exposed to 0 or 0.8 parts per million ozone for 1 day or 9 consecutive weekdays (4 hr/day)...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28882797/modification-of-the-plasma-complement-protein-profile-by-exogenous-estrogens-is-indicative-of-a-compromised-immune-competence-in-marine-medaka-oryzias-melastigma
#9
Miao Dong, Frauke Seemann, Joseph L Humble, Yimin Liang, Drew R Peterson, Rui Ye, Honglin Ren, Hui-Su Kim, Jae-Seong Lee, Doris W T Au, Yun Wah Lam
Growing evidence suggests that the immune system of teleost is vulnerable to xenoestrogens, which are ubiquitous in the marine environment. This study detected and identified the major circulatory immune proteins deregulated by 17α-ethinylestradiol (EE2), which may be linked to fish susceptibility to pathogens in the marine medaka, Oryzias melastigma. Fish immune competence was determined using a host resistance assay to pathogenic bacteria Edwardsiella tarda. Females were consistently more susceptible to infection-induced mortality than males...
September 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28857578/awe-and-humility
#10
Jennifer E Stellar, Amie Gordon, Craig L Anderson, Paul K Piff, Galen D McNeil, Dacher Keltner
Humility is a foundational virtue that counters selfish inclinations such as entitlement, arrogance, and narcissism (Tangney, 2000). We hypothesize that experiences of awe promote greater humility. Guided by an appraisal-tendency framework of emotion, we propose that when individuals encounter an entity that is vast and challenges their worldview, they feel awe, which leads to self-diminishment and subsequently humility. In support of these claims, awe-prone individuals were rated as more humble by friends (Study 1) and reported greater humility across a 2-week period (Study 2), controlling for other positive emotions...
August 31, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/28847119/in-reply-to-small-stories-in-defense-of-the-humble-case-report
#11
LETTER
Hussam Abou-Al-Shaar, Abdulrahman J Sabbagh
No abstract text is available yet for this article.
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28847118/small-stories-in-defense-of-the-humble-case-report
#12
LETTER
Christopher S Graffeo, Avital Perry, Lucas P Carlstrom, William R Copeland, Kathryn M Van Abel, Michael J Link
No abstract text is available yet for this article.
September 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28831545/how-the-humble-insect-brain-became-a-powerful-experimental-model-system
#13
REVIEW
Heinrich Reichert
In the 21st century, neurobiological studies focused on the insect brain are revealing unprecedented insight into the molecular, cellular, developmental, and circuit aspects of brain organization and function, notably in the genetic model system of Drosophila melanogaster. Underlying this accelerating progress in understanding the insect brain is a century-long history of ground breaking experimental investigation, methodological advance, and conceptual insight catalyzed by the integration of two emerging research fields, neuroscience and genetics...
November 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28829441/nk-cells-join-the-plasticity-party
#14
Jonathan S Silver, Alison A Humbles
No abstract text is available yet for this article.
August 22, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28792579/-a-new-challenge-of-working-together-psychiatry-and-heraing-voices
#15
Christian Laval
Recovery model, as the hearing voices movement, promotes the users discourse among the health workers. This interference of users in the expertise considering the meaning of their voices is faced with the vision of advocating health workers, particularly the psychiatrists supporting the psychiatric users movement. On the field, this association seems challenging. On the experimental site in Marseille, professionals through various tensions and practical difficulties tend to reconsider their power / knowledge...
2017: Santé Mentale Au Québec
https://www.readbyqxmd.com/read/28782216/temporal-changes-in-neutropenic-blood-culture-isolates-and-disease-associations-a-single-centre-series-of-1139-episodes
#16
Nathanael Lucas, Michael Humble, Dalice Sim, Michelle Balm, John Carter, Robert Weinkove
Neutropenic infections are life-threatening and require empiric antibiotic treatment. We examined 1139 blood culture isolates from our institution over a 36-year period from neutropenic patients to examine temporal trends and disease associations. Positive associations were found between viridans streptococci and acute myeloid leukaemia, coagulase negative staphylococci and acute lymphoblastic leukaemia and Pseudomonas aeruginosa and indolent B-cell malignancies.
August 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28764950/prognosis-after-cardiac-arrest-vindication-of-the-humble-ct-scan
#17
EDITORIAL
G Bryan Young
No abstract text is available yet for this article.
July 29, 2017: Resuscitation
https://www.readbyqxmd.com/read/28755564/measurements-of-argon-39-at-the-u20az-underground-nuclear-explosion-site
#18
J I McIntyre, C E Aalseth, T R Alexander, H O Back, B J Bellgraph, T W Bowyer, V Chipman, M W Cooper, A R Day, S Drellack, M P Foxe, B G Fritz, J C Hayes, P Humble, M E Keillor, R R Kirkham, E J Krogstad, J D Lowrey, E K Mace, M F Mayer, B D Milbrath, A Misner, S M Morley, M E Panisko, K B Olsen, M D Ripplinger, A Seifert, R Suarez
Pacific Northwest National Laboratory reports on the detection of (39)Ar at the location of an underground nuclear explosion on the Nevada Nuclear Security Site. The presence of (39)Ar was not anticipated at the outset of the experimental campaign but results from this work demonstrated that it is present, along with (37)Ar and (85)Kr in the subsurface at the site of an underground nuclear explosion. Our analysis showed that by using state-of-the-art technology optimized for radioargon measurements, it was difficult to distinguish (39)Ar from the fission product (85)Kr...
July 26, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28746485/an-interview-with-steven-j-lindauer
#19
Steven J Lindauer
There are so many compliments to Dr. Steven Lindauer that is hard for one to figure where to start from… Well, travelling backwards in time, all the way to the year 2000, I went to Virginia to study English at Virginia Commonwealth University (VCU), in Richmond, Virginia, USA. During my daily walks to the English school, I used to pass by the School of Dentistry, where the Department of Orthodontics was. That was the place where my very first "contact" with the VCU happened. In 2015, 15 years later, I had the pleasure to go back to the VCU and spend two days with Dr...
May 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/28710948/brainstem-auditory-evoked-potentials-for-diagnosing-autism-spectrum-disorder-adhd-and-schizophrenia-spectrum-disorders-in-adults-a-blinded-study
#20
Irina Manouilenko, Mats B Humble, Jeanette Georgieva, Susanne Bejerot
The aim of the present study was to examine the clinical utility of complex auditory brainstem response (c-ABR) and investigate if c-ABR is helpful in the diagnostic procedure. Thirty-one adult psychiatric patients, thoroughly diagnosed with autism spectrum disorder (ASD) (n=16), ADHD (n=8), or schizophrenia spectrum disorder (SSD) (n=7) and 15 healthy controls (HC), were blindly assessed with SensoDetect BERA. This c-ABR correctly identified psychiatric diagnoses in 4 patients (13%) and provided partially correct diagnoses in 11 more patients...
July 6, 2017: Psychiatry Research
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