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https://www.readbyqxmd.com/read/29664617/expanded-theory-of-h-and-j-molecular-aggregates-the-effects-of-vibronic-coupling-and-intermolecular-charge-transfer
#1
Nicholas J Hestand, Frank C Spano
The electronic excited states of molecular aggregates and their photophysical signatures have long fascinated spectroscopists and theoreticians alike since the advent of Frenkel exciton theory almost 90 years ago. The influence of molecular packing on basic optical probes like absorption and photoluminescence was originally worked out by Kasha for aggregates dominated by Coulombic intermolecular interactions, eventually leading to the classification of J- and H-aggregates. This review outlines advances made in understanding the relationship between aggregate structure and photophysics when vibronic coupling and intermolecular charge transfer are incorporated...
April 17, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29652406/individual-importance-weighting-of-domain-satisfaction-ratings-does-not-increase-validity
#2
Julia M Rohrer, Stefan C Schmukle
Bottom-up models of life satisfaction are based on the assumption that individuals judge the overall quality of their lives by aggregating information across various life domains, such as health, family, and income. This aggregation supposedly involves a weighting procedure because individuals care about different parts of their lives to varying degrees. Thus, composite measures of well-being should be more accurate if domain satisfaction scores are weighted by the importance that respondents assign to the respective domains...
2018: Collabra. Psychology
https://www.readbyqxmd.com/read/29624171/the-humble-case-report-bottom-of-the-evidence-based-medical-pyramid-or-the-foundation-of-clinical-research
#3
Darren Mylotte
No abstract text is available yet for this article.
April 6, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29608141/senescent-cells-a-therapeutic-target-for-cardiovascular-disease
#4
Bennett G Childs, Hu Li, Jan M van Deursen
Cellular senescence, a major tumor-suppressive cell fate, has emerged from humble beginnings as an in vitro phenomenon into recognition as a fundamental mechanism of aging. In the process, senescent cells have attracted attention as a therapeutic target for age-related diseases, including cardiovascular disease (CVD), the leading cause of morbidity and mortality in the elderly. Given the aging global population and the inadequacy of current medical management, attenuating the health care burden of CVD would be transformative to clinical practice...
April 2, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29588030/the-mouse-as-a-model-organism-for-assessing-anesthetic-sensitivity
#5
Andrzej Z Wasilczuk, Kaitlyn L Maier, Max B Kelz
The mouse has been used in many medical fields as a powerful model to reveal the genetic basis of human physiology and disease. The past two decades have witnessed an enormous wealth of genetic and informatic resources dedicated to this humble organism. With the ongoing revolution in mapping neural circuitry governing behavior, the mouse is an ideal model organism poised to unravel the mysteries of general anesthetic action. This chapter will describe and provide guidelines for anesthetic phenotyping in the mouse including both motor-dependent and motor-independent assessments...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29579406/a-life-in-food-a-grain-of-salt-and-some-humble-pie
#6
Michael J Gibney
From my senior school days, I had wanted to pursue a career in food. In quite what capacity I was not too sure. So my starting points were within the fields of animal nutrition before moving for the major part of my career to medical schools to study human nutrition and health. My career scientific achievements lie within the Kuhnian spectrum of normal science, but within that normality, I was always one to challenge conventional wisdom. An academic career is about more than just research. It is about teaching and not just the minutiae of nutrition, but about life and living, about challenges and failures...
March 26, 2018: Annual Review of Nutrition
https://www.readbyqxmd.com/read/29555257/biomedical-waste-management-in-ayurveda-hospitals-current-practices-future-prospectives
#7
REVIEW
Renju Rajan, Delvin T Robin, Vandanarani M
Biomedical waste management is an integral part of traditional and contemporary system of health care. The paper focuses on the identification and classification of biomedical wastes in Ayurvedic hospitals, current practices of its management in Ayurveda hospitals and its future prospective. Databases like PubMed (1975-2017 Feb), Scopus (1960-2017), AYUSH Portal, DOAJ, DHARA and Google scholar were searched. We used the medical subject headings 'biomedical waste' and 'health care waste' for identification and classification...
March 16, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29553987/chronic-postsurgical-pain-and-cancer-the-catch-of-surviving-the-unsurvivable
#8
Stephen R Humble, Nicolas Varela, Asantha Jayaweera, Arun Bhaskar
PURPOSE OF REVIEW: Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer. Unfortunately, general consensus is lacking as to how best reduce the risk of developing CPSP. RECENT FINDINGS: Cancer is now not always a short-lived, fatal disease and is now moving towards a chronic illness. Poorly managed perioperative pain is the greatest risk factor for CPSP...
March 16, 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29550644/a-web-based-resource-for-promoting-equity-in-midwifery-education-and-training-towards-meaningful-diversity-and-inclusion
#9
Kristin J Effland, Karen Hays
Increasing the midwifery workforce requires that aspiring midwives complete education and training, but structural racism and microaggressions impact the lives of underrepresented midwifery students and apprentices, adding stressors and disparities to the usual demanding educational challenges. In order to be resilient, students rely on preceptors, faculty, administrators and institutions to promote equity. Equity-focused learning environments improve student experiences and success rates, and better prepare all students to provide culturally humble and sensitive care to diverse childbearing persons and other essential competencies outlined by the International Confederation of Midwives...
February 15, 2018: Midwifery
https://www.readbyqxmd.com/read/29541573/spontaneous-resolution-of-a-confounding-insular-lesion
#10
Ali S Haider, Christopher S Graffeo, Avital Perry, Lucas P Carlstrom, Terry C Burns
Insular gliomas were previously considered inoperable lesions and were typically treated via biopsy, chemotherapy and/or radiation, if not observation alone. Stereotactic biopsies of low grade insular gliomas can underestimate tumor grade or fail to establish malignancy. Moreover, the survival advantages of maximal safe resection for insular lesions are increasingly being recognized. As such, early surgical resection is increasingly being performed. As with most lesions, a differential diagnosis exists for apparent insular gliomas, with definitive diagnosis generally obtained upon resection...
January 11, 2018: Curēus
https://www.readbyqxmd.com/read/29517051/ode-to-the-humble-southern-blot-in-the-era-of-exomes
#11
EDITORIAL
Alex R Paciorkowski
No abstract text is available yet for this article.
February 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29503281/from-syrian-refugee-to-dishwasher-to-heart-doctor-the-inspirational-story-of-hero-and-humanitarian-dr-heval-kelli
#12
Meira Mahmoud Yasin
It has been said that those with the least are often the ones with the most to give. This proved to be true for a Syrian refugee turned cardiologist who provides care in communities that are poor and underserved including refugees, immigrants, minorities, those of low socioeconomic status, and other vulnerable populations. Dr. Heval Kelli is the epitome of a kind-hearted, humble, genuine hero, through his dedication to serving humanity. Between providing health care to those in need, educating future generations of doctors, mentoring high school students, and advocating for the less fortunate, his life is truly his message to the world...
2018: Journal of Health Care for the Poor and Underserved
https://www.readbyqxmd.com/read/29495075/vacuolar-protein-sorting-26c-encodes-an-evolutionarily-conserved-large-retromer-subunit-in-eukaryotes-that-is-important-for-root-hair-growth-in-arabidopsis-thaliana
#13
Suryatapa Ghosh Jha, Emily R Larson, Jordan Humble, David S Domozych, David S Barrington, Mary L Tierney
The large retromer complex participates in diverse endosomal trafficking pathways and is essential for plant developmental programs including cell polarity, programmed cell death, and shoot gravitropism in Arabidopsis. Here we demonstrate that an evolutionarily conserved VPS26 protein (VPS26C; At1G48550) functions in a complex with VPS35A and VPS29 necessary for root hair growth in Arabidopsis. Bimolecular Fluorescence Complementation showed that VPS26C forms a complex with VPS35A in the presence of VPS29 and this is supported by genetic studies showing that vps29 and vps35a mutants exhibit altered root hair growth...
March 1, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29484023/integrative-dermatology-the-use-of-herbals-and-nutritional-supplements-to-treat-dermatological-conditions
#14
REVIEW
Michael Tirant, Torello Lotti, Serena Gianfaldoni, Georgi Tchernev, Uwe Wollina, Philip Bayer
From humble beginnings at the dawn of time to it's advanced and successful status today, this essay traces the history of natural medicine and the development of integrated dermatology to what it is today. Some of the most well-known natural (international and Australian) products with an application in dermatology are discussed. The history and functions of the Psoriasis Eczema Clinic and the products developed by its founder, Prof. Michael Tirant, are explained.
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29462087/prognosis-of-diffuse-axonal-injury-with-traumatic-brain-injury
#15
Stephen S Humble, Laura D Wilson, Li Wang, Drew A Long, Miya A Smith, Jonathan C Siktberg, Mina F Mirhoseini, Aashim Bhatia, Sumit Pruthi, Matthew A Day, Susanne Muehlschlegel, Mayur B Patel
BACKGROUND: Determine the prognostic impact of MRI-defined DAI after TBI on functional outcomes, quality of life, and 3-year mortality. METHODS: This retrospective single center cohort included adult trauma patients (age>17y) admitted from 2006-2012 with TBI. Inclusion criteria were positive head CT with brain MRI within 2 weeks of admission. Exclusion criteria included penetrating TBI or prior neurologic condition. Separate ordinal logistic models assessed DAI's prognostic value for following scores: 1)hospital-discharge Functional Independence Measure (FIM); 2)long-term Glasgow Outcome Scale-Extended (GOSE); and 3)long-term Quality of Life after Brain Injury-Overall Scale (QOLIBRI-OS)...
February 17, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29436817/protective-layer-development-for-enhancing-stability-and-drug-delivery-capabilities-of-des-surface-crystallized-coatings
#16
Shady Farah
Carrier-free drug eluting stents (DES) based crystalline coatings are gaining prominence due to their function, skipping many limitations and clinical complications of the currently marketed DES. However, their usage has been humbled by crystalline coating inflexibility, limited mechanical and physical properties. This study reports for the first time a protective top coating development for enhancing crystalline coating merits and delivery capabilities. Flexible and water soluble polysaccharide top coating was developed and applied onto Rapamycin (RM) crystalline carpet...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29430197/profile-of-buparlisib-and-its-potential-in-the-treatment-of-breast-cancer-evidence-to-date
#17
REVIEW
Carmen Criscitiello, Giulia Viale, Giuseppe Curigliano, Aron Goldhirsch
Alteration of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin signaling pathway is key for the growth and survival of several cancers, including breast cancer. In addition, dysregulation of PI3K signaling may contribute to resistance to several anticancer agents. PI3K inhibitors may, therefore, be effective as antineoplastic therapy. Buparlisib is a potent and highly specific oral inhibitor of the pan-class I PI3K family. Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase signaling pathway in an ATP-competitive manner, thus inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate and activation of the PI3K signaling pathway...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29428011/ren%C3%A3-ger%C3%A3-nimo-favaloro-1923-2000-a-man-who-struggled-with-matters-of-the-heart
#18
Robyn Rubenstein, Scott W Cowan, Charles J Yeo, John W Entwistle
René Gerónimo Favaloro prided himself on being a "simple country doctor." Born in La Plata, Argentina, Dr. Favaloro had an interest in Argentina's sociopolitical and healthcare systems beginning at a young age. He began his medical education at La Universidad Nacional de La Plata, graduating in 1949 with plans to continue his medical education in the field of surgery; however, in 1950, Dr. Favaloro temporarily resigned from his position as a surgeon to work as a country doctor in a small province of La Pampa, Argentina...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29416864/a-national-survey-of-pain-clinics-within-the-united-kingdom-and-ireland-focusing-on-the-multidisciplinary-team-and-the-incorporation-of-the-extended-nursing-role
#19
Pungavi Kailainathan, Stephen Humble, Helen Dawson, Fiona Cameron, Shyam Gokani, Gursimren Lidder
Inconsistencies in the availability and quality of pain service provision have been noted nationally, as have lengthy waiting times for appointments and lack of awareness of the Pain Clinic role. The 2013 NHS England report stated that specialist pain services must offer multispecialty and multidisciplinary pain clinics. This national survey of multidisciplinary pain service provision in the United Kingdom and Ireland provides a snapshot of pain service provision in order to review and highlight what variations exist in multidisciplinary team (MDT) provision and working patterns...
February 2018: British Journal of Pain
https://www.readbyqxmd.com/read/29381087/the-evolution-of-coronary-stents
#20
Peter McKavanagh, George Zawadowski, Naveed Ahmed, Michael Kutryk
Percutaneous coronary intervention (PCI) is 40 years old this year. From its humble beginnings of experimental work, PCI has transitioned over years with coronary artery stenting now a standard medical procedure performed throughout the world. Areas covered: The conversion from plain old balloon angioplasty (POBA) to the present era of drug eluting stents (DES) has been driven by many technological advances and large bodies of clinical trial evidence. The journey to present day practice has seen many setbacks, such as acute vessel closure with POBA; rates of instant restenosis with bare metal stents (BMS) and more recently, high rates of stent thrombosis with bioabsorbable platforms...
January 30, 2018: Expert Review of Cardiovascular Therapy
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