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https://www.readbyqxmd.com/read/28078310/polg2-deficiency-causes-adult-onset-syndromic-sensory-neuropathy-ataxia-and-parkinsonism
#1
Lionel Van Maldergem, Arnaud Besse, Boel De Paepe, Emma L Blakely, Vivek Appadurai, Margaret M Humble, Juliette Piard, Kate Craig, Langping He, Pierre Hella, François-Guillaume Debray, Jean-Jacques Martin, Marion Gaussen, Patrice Laloux, Giovanni Stevanin, Rudy Van Coster, Robert W Taylor, William C Copeland, Eric Mormont, Penelope E Bonnen
OBJECTIVE: Mitochondrial dysfunction plays a key role in the pathophysiology of neurodegenerative disorders such as ataxia and Parkinson's disease. We describe an extended Belgian pedigree where seven individuals presented with adult-onset cerebellar ataxia, axonal peripheral ataxic neuropathy, and tremor, in variable combination with parkinsonism, seizures, cognitive decline, and ophthalmoplegia. We sought to identify the underlying molecular etiology and characterize the mitochondrial pathophysiology of this neurological syndrome...
January 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28068894/strain-differences-in-a-murine-model-of-air-pollutant-induced-nonatopic-asthma-and-rhinitis
#2
Jack R Harkema, Lucas A Hotchkiss, Nicholas A Vetter, Daven N Jackson-Humbles, Ryan P Lewandowski, James G Wagner
Ozone is an irritating gas found in photochemical smog. Epidemiological associations have been made between the onset of asthma and childhood exposures to increasing levels of ambient ozone (i.e., air pollutant-induced nonatopic asthma). Individuals, however, vary in their susceptibility to this outdoor air pollutant, which may be due, in part, to their genetic makeup. The present study was designed to test the hypothesis that there are murine strain-dependent differences in pulmonary and nasal pathologic responses to repeated ozone exposures...
January 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28068228/humbling-advances-in-technology-protons-brainstem-necrosis-and-the-self-driving-car
#3
Shannon M MacDonald, Nadia N Laack, Stephanie Terezakis
No abstract text is available yet for this article.
February 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28039648/leadership-development-in-a-professional-medical-society-using-360-degree-survey-feedback-to-assess-emotional-intelligence
#4
Paul J Gregory, Benjamin Robbins, Steven D Schwaitzberg, Larry Harmon
BACKGROUND: The current research evaluated the potential utility of a 360-degree survey feedback program for measuring leadership quality in potential committee leaders of a professional medical association (PMA). Emotional intelligence as measured by the extent to which self-other agreement existed in the 360-degree survey ratings was explored as a key predictor of leadership quality in the potential leaders. STUDY DESIGN: A non-experimental correlational survey design was implemented to assess the variation in leadership quality scores across the sample of potential leaders...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28039405/role-of-baff-in-pulmonary-autoantibody-responses-induced-by-chronic-cigarette-smoke-exposure-in-mice
#5
Mathieu C Morissette, Yang Gao, Pamela Shen, Danya Thayaparan, Jean-Christophe Bérubé, Peter D Paré, Corry-Anke Brandsma, Ke Hao, Yohan Bossé, Rachel Ettinger, Ronald Herbst, Alison A Humbles, Roland Kolbeck, Nanshan Zhong, Rongchang Chen, Martin R Stämpfli
Emerging evidence suggests that autoimmune processes are implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD). In this study, we assessed the expression of B-cell activating factor (BAFF) in smokers, and investigated the functional importance of BAFF in the induction and maintenance of cigarette smoke-induced pulmonary antinuclear antibodies (ANA) and tertiary lymphoid tissues (TLTs) using a preclinical mouse model. We observed that BAFF levels were elevated in smokers and mice exposed to cigarette smoke...
December 2016: Physiological Reports
https://www.readbyqxmd.com/read/28034577/10-lessons-learned-by-a-misguided-physician
#6
REVIEW
Barry E Levin
It was a great and humbling honor to receive the 2016 Distinguished Career Award from my SSIB colleagues. This paper summarizes the major points of my DCA talk at the 2016 annual meeting. It is a reflection on my 50year medical and research career and 10 lessons I have learned over those years which might be of help to young investigators near the beginning of their own research careers. These lessons include: the value of being receptive to the opportunities provided you; how clinician-scientists can serve as critical role models for young investigators like me and a history of how my career developed as a result of their influence; the importance of carefully examining your own data, particularly when it doesn't agree with your preconceived ideas; the critical role that students, postdocs and PhD (and even veterinarian) colleagues can play in developing one's career; the likelihood that your career path will have many interesting twists and turns determined by changes in your own scientific interests and how rewarding various areas of research focus are to you; the importance of building a close-knit laboratory staff family; the fact that science and romance can mix...
December 26, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28033179/a-simple-hug-and-a-humble-heart
#7
David A Smith
No abstract text is available yet for this article.
January 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28017500/methods-for-using-argon-39-to-age-date-groundwater-using-ultra-low-background-proportional-counting
#8
Emily Mace, Craig Aalseth, Jill Brandenberger, Anthony Day, Eric Hoppe, Paul Humble, Martin Keillor, Justin Kulongoski, Cory Overman, Mark Panisko, Allen Seifert, Signe White, Eric Wilcox Freeburg, Richard Williams
Argon-39 can be used as a tracer for age-dating glaciers, oceans, and more recently, groundwater. With a half-life of 269 years, (39)Ar fills an intermediate age range gap (50-1,000 years) not currently covered by other common groundwater tracers. Therefore, adding this tracer to the data suite for groundwater studies provides an important tool for improving our understanding of groundwater systems. We present the methods employed for arriving at an age-date for a given sample of argon degassed from groundwater...
December 21, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/27957621/efficacy-feasibility-and-acceptability-of-a-novel-technology-based-intervention-to-support-physical-activity-in-cancer-survivors
#9
Nancy M Gell, Kristin W Grover, Morgan Humble, Michelle Sexton, Kim Dittus
PURPOSE: Physical activity is known to minimize the long-term side effects of cancer treatment. Yet, rates of physical activity participation by cancer survivors are significantly lower compared to the general population. The purpose of this pilot study was to examine the efficacy, feasibility, and acceptability of a technology-based intervention to promote maintenance of physical activity after completing an exercise-based oncology rehabilitation program. METHODS: The pre-post 4-week intervention included support delivered through tailored text messages, Fitbit® self-monitoring, and brief health coaching sessions...
December 13, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27938030/a-humble-letter-to-a-very-sick-friend-a-suggestive-missive
#10
Paul J Moon
No abstract text is available yet for this article.
October 2016: Journal of Social Work in End-of-life & Palliative Care
https://www.readbyqxmd.com/read/27917586/a-qualitative-perspectival-review-of-the-australian-and-new-zealand-urology-education-and-training-program
#11
Prem Rashid
OBJECTIVES: To conduct a prospective, qualitative review to explore the challenges associated with the delivery of current and future high-quality urological training, and to report the reflective considerations and opinions of leaders in the Australian and New Zealand (ANZ) urological surgical training programme. METHODS: Ethics-approved semi-structured, template-based, qualitative interview techniques were used to evaluate key aspects of the current urology training programme...
December 5, 2016: BJU International
https://www.readbyqxmd.com/read/27887970/production-and-release-rate-of-37-ar-from-the-ut-triga-mark-ii-research-reactor
#12
Christine Johnson, Steven R Biegalski, Edward J Artnak, Ethan Moll, Derek A Haas, Justin D Lowrey, Craig E Aalseth, Allen Seifert, Emily K Mace, Vincent T Woods, Paul Humble
Air samples were taken at various locations around The University of Texas at Austin's TRIGA Mark II research reactor and analyzed to determine the concentrations of (37)Ar, (41)Ar, and (133)Xe present. The measured ratio of (37)Ar/(41)Ar and historical records of (41)Ar releases were then utilized to estimate an annual average release rate of (37)Ar from the reactor facility. Using the calculated release rate, atmospheric transport modeling was performed in order to determine the potential impact of research reactor operations on nearby treaty verification activities...
February 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/27862941/a-century-of-heparin-past-present-and-future
#13
H C Hemker
Heparin was discovered around 1922 by Howell (Baltimore) and was further developed by the teams of Best (Toronto) and Jorpes (Stockholm). Kakkar (London) propagated its routine use for the prevention of postoperative thrombosis from 1971 onwards. The discovery of low molecular weight heparins (1976, Johnson, London) and their development in the subsequent years led to the present arsenal of clinically useful drugs. In 1976, three teams independently found that a specific structure in heparin binds tightly to antithrombin...
December 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27820611/the-rainbow-of-extra-blood-tubes-useful-or-wasteful-practice
#14
Robert M Humble, Hermann G Hounkponou, Matthew D Krasowski
No abstract text is available yet for this article.
January 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27812230/time-to-response-toxicity-analysis-as-a-method-for-drug-susceptibility-assessment-in-salmon-lice
#15
Greta Carmona-Antoñanzas, Joseph L Humble, Stephen N Carmichael, Jan Heumann, Hayden R L Christie, Darren M Green, David I Bassett, James E Bron, Armin Sturm
: The salmon louse Lepeophtheirus salmonis (Krøyer, 1837) is an ectoparasite causing infections of wild and farmed Atlantic salmon (Salmo salar L.) in the Northern hemisphere. While L. salmonis control at commercial mariculture sites increasingly employs non-medicinal approaches, such as cage designs reducing infection rates and biological control through cleaner fish, anti-parasitic drugs are still a requirement for effective fish health care. With only a limited range of salmon delousing agents available, all of which have been in use for more than a decade, drug resistance formation has been reported for different products...
November 1, 2016: Aquaculture
https://www.readbyqxmd.com/read/27791309/a-very-human-being-sister-marie-simone-roach-1922-2016
#16
Michael J Villeneuve, Verena Tschudin, Janet Storch, Marsha D M Fowler, Elizabeth Peter
Sister (Sr.) Marie Simone Roach, of the Sisters of St. Martha of Antigonish, Nova Scotia, died at the Motherhouse on 2 July 2016 at the age of 93, leaving behind a rich legacy of theoretical and practical work in the areas of care, caring and nursing ethics. She was a humble soul whose deep and scholarly thinking thrust her onto the global nursing stage where she will forever be tied to a central concept in nursing, caring, through her Six Cs of Caring model. In Canada, she was the lead architect of the Canadian Nurses Association's first code of ethics, and her influence on revisions to it is still profound more than 35 years later...
October 28, 2016: Nursing Inquiry
https://www.readbyqxmd.com/read/27764821/sesquicentennial-tribute-to-emil-redlich-1866-1930-the-embodied-conscience-of-neurology
#17
Nicolina E Savvaidou, Lazaros C Triarhou
Professor Emil Redlich (1866-1930) of the University of Vienna was born 150 years ago. Raised in a humble environment, he became an eminent researcher and neurology scholar, and succeeded in laying some of the key foundations of neuroanatomy and neuropathology. His name is linked to medical eponyms that define the dorsal root entry zone into the spinal cord, epidemic disseminated encephalomyelitis, narcolepsy, senile plaques and dementia. As its first director, he managed to organize the Maria-Theresien-Schlössel into a first-class neuropsychiatric hospital...
2016: European Neurology
https://www.readbyqxmd.com/read/27746897/proximal-hypospadias-we-aren-t-always-keeping-our-promises
#18
Christopher J Long, Douglas A Canning
Hypospadias surgery is a humbling art form. The evolution of surgical techniques has made distal hypospadias outcomes favorable, but recent publications suggest that our complication rates for proximal hypospadias are much higher than previously reported. To explain these shortcomings, we examine the literature and focus on the lack of standardized documentation, the subsequent inability to objectify the severity of the phenotype, and the underestimation of complications due to lack of long-term follow up. The variability in surgical technique and the fact that the literature abounds with small case series from single institutions also limits our ability to compare outcomes...
2016: F1000Research
https://www.readbyqxmd.com/read/27740854/tracheostomy-risk-factors-and-outcomes-after-severe-traumatic-brain-injury
#19
Stephen S Humble, Laura D Wilson, John W McKenna, Taylor C Leath, Yanna Song, Mario A Davidson, Jesse M Ehrenfeld, Oscar D Guillamondegui, Pratik P Pandharipande, Mayur B Patel
OBJECTIVE: To determine risk factors associated with tracheostomy placement after severe traumatic brain injury (TBI) and subsequent outcomes among those who did and did not receive a tracheostomy. METHODS: This retrospective cohort study compared adult trauma patients with severe TBI (n = 583) who did and did not receive tracheostomy. A multivariable logistic regression model assessed the associations between age, sex, race, insurance status, admission GCS, AIS (Head, Face, Chest) and tracheostomy placement...
2016: Brain Injury: [BI]
https://www.readbyqxmd.com/read/27719698/spain-s-magic-mountain-narrating-prehistory-at-atapuerca
#20
Oliver Hochadel
The Sierra de Atapuerca in northern Spain is ranked among the most important excavation sites in human origins research worldwide. The project boasts not only spectacular hominid fossils, among them the 'oldest European', but also a fully fledged 'popularization industry'. This article interprets this multimedia industry as a generator of different narratives about the researchers as well as about the prehistoric hominids of Atapuerca. It focuses on the popular works of the three co-directors of the project...
September 2016: British Journal for the History of Science
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