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https://www.readbyqxmd.com/read/29436817/protective-layer-development-for-enhancing-stability-and-drug-delivery-capabilities-of-des-surface-crystallized-coatings
#1
Shady Farah
Carrier-free drug eluting stents (DES) based crystalline coatings are gaining prominence due to their function, skipping many limitations and clinical complications of the currently marketed DES. However, their usage has been humbled by crystalline coating inflexibility, limited mechanical and physical properties. This study reports for the first time a protective top coating development for enhancing crystalline coating merits and delivery capabilities. Flexible and water soluble polysaccharide top coating was developed and applied onto Rapamycin (RM) crystalline carpet...
February 13, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29430197/profile-of-buparlisib-and-its-potential-in-the-treatment-of-breast-cancer-evidence-to-date
#2
REVIEW
Carmen Criscitiello, Giulia Viale, Giuseppe Curigliano, Aron Goldhirsch
Alteration of the phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin signaling pathway is key for the growth and survival of several cancers, including breast cancer. In addition, dysregulation of PI3K signaling may contribute to resistance to several anticancer agents. PI3K inhibitors may, therefore, be effective as antineoplastic therapy. Buparlisib is a potent and highly specific oral inhibitor of the pan-class I PI3K family. Buparlisib specifically inhibits class I PIK3 in the PI3K/AKT kinase signaling pathway in an ATP-competitive manner, thus inhibiting the production of the secondary messenger phosphatidylinositol (3,4,5)-trisphosphate and activation of the PI3K signaling pathway...
2018: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/29428011/ren%C3%A3-ger%C3%A3-nimo-favaloro-1923-2000-a-man-who-struggled-with-matters-of-the-heart
#3
Robyn Rubenstein, Scott W Cowan, Charles J Yeo, John W Entwistle
René Gerónimo Favaloro prided himself on being a "simple country doctor." Born in La Plata, Argentina, Dr. Favaloro had an interest in Argentina's sociopolitical and healthcare systems beginning at a young age. He began his medical education at La Universidad Nacional de La Plata, graduating in 1949 with plans to continue his medical education in the field of surgery; however, in 1950, Dr. Favaloro temporarily resigned from his position as a surgeon to work as a country doctor in a small province of La Pampa, Argentina...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29416864/a-national-survey-of-pain-clinics-within-the-united-kingdom-and-ireland-focusing-on-the-multidisciplinary-team-and-the-incorporation-of-the-extended-nursing-role
#4
Pungavi Kailainathan, Stephen Humble, Helen Dawson, Fiona Cameron, Shyam Gokani, Gursimren Lidder
Inconsistencies in the availability and quality of pain service provision have been noted nationally, as have lengthy waiting times for appointments and lack of awareness of the Pain Clinic role. The 2013 NHS England report stated that specialist pain services must offer multispecialty and multidisciplinary pain clinics. This national survey of multidisciplinary pain service provision in the United Kingdom and Ireland provides a snapshot of pain service provision in order to review and highlight what variations exist in multidisciplinary team (MDT) provision and working patterns...
February 2018: British Journal of Pain
https://www.readbyqxmd.com/read/29381087/the-evolution-of-coronary-stents
#5
Peter McKavanagh, George Zawadowski, Naveed Ahmed, Michael Kutryk
Percutaneous coronary intervention (PCI) is 40 years old this year. From its humble beginnings of experimental work, PCI has transitioned over years with coronary artery stenting now a standard medical procedure performed throughout the world. Areas covered: The conversion from plain old balloon angioplasty (POBA) to the present era of drug eluting stents (DES) has been driven by many technological advances and large bodies of clinical trial evidence. The journey to present day practice has seen many setbacks, such as acute vessel closure with POBA; rates of instant restenosis with bare metal stents (BMS) and more recently, high rates of stent thrombosis with bioabsorbable platforms...
January 30, 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29355705/a-brief-history-of-modern-ageing-research
#6
REVIEW
Kayvan Zainabadi
Over the last few decades, ageing research has emerged as a vibrant area of rigorous scientific study. With its humble beginnings in yeast and worms, the field has progressed so dramatically that scientists are now able to extend the lifespan of mice with use of small molecule drugs. However, it was not too long ago that answering the more basic question, whether ageing itself was amenable to scientific study, was itself a topic of contentious debate. To begin to understand how a field that was initially thought of as pseudoscience has come so far, it is instructive to understand its roots in both theory and practice...
January 17, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29349812/drug-promotion-practices-a-review
#7
Nilan T Jacob
Over the years, the pharmaceutical industry has been at the forefront of research and innovation in drug discovery and development. The process of drug discovery extending from pre-clinical studies to multi-centric clinical trials and post-marketing phase is a costly affair running into billions of dollars. On the flip side, not all investigational molecules clear the trial phases and get approved; which puts pressure on the manufacturers to maximise the profit from approved drugs. It is in this key area, the practice of drug promotion plays its role...
January 18, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29306368/spotlight-on-the-humble-chest-x-ray
#8
EDITORIAL
J Nightingale
No abstract text is available yet for this article.
February 2018: Radiography
https://www.readbyqxmd.com/read/29305803/lead-bioaccumulation-in-texas-harvester-ants-pogonomyrmex-barbatus-and-toxicological-implications-for-texas-horned-lizard-phrynosoma-cornutum-populations-of-bexar-county-texas
#9
Robert Burgess, Robert Davis, Deborah Edwards
Uptake of lead from soil was examined in order to establish a site-specific ecological protective concentration level for the Texas Horned Lizard (Phrynosoma cornutum) at the Former Humble Refinery in San Antonio, Texas. Soils, harvester ants, and rinse water from the ants were analyzed at 11 Texas Harvester Ant (Pogonomyrmex barbatus) mounds. Soil concentrations at the harvester ant mounds ranged from 13 to 7474 mg/kg of lead dry weight. Ant tissue sample concentrations ranged from < 0.82 to 21.17 mg/kg dry weight...
January 5, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29243719/event-report-a-heart-warming-and-truly-humbling-experience
#10
(no author information available yet)
No abstract text is available yet for this article.
December 15, 2017: British Dental Journal
https://www.readbyqxmd.com/read/29225749/humble-foley-s-catheter-to-the-rescue-in-a-case-of-t-tube-insertion-a-case-report
#11
Upasana Goswami, Praneet Singh
The Montgomery T-tube poses a challenge to anesthesiologists because of loss of anesthetic gases through the open proximal end of the vertical limb and lack of standard anesthesia circuit connectors. Here, we present a case of a 25-year-old woman with a reported history of accidental strangulation 18 months previously. The patient had a metallic tracheostomy tube in situ due to the development of tracheal stenosis. Computed tomography showed significant narrowing in a 7-8-mm segment, 2 cm proximal to the tracheostomy tube in situ...
December 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29154640/when-saying-i-m-best-is-benign-developmental-shifts-in-perceptions-of-boasting
#12
Kristi L Lockhart, Mariel K Goddu, Frank C Keil
Four studies explored developmental changes in attitudes toward boasting. Overall, 5- to 7-year-olds (N = 130) were more likely than 8- to 11-year-olds (N = 126) and adults (N = 263) to view characters who boasted about valued traits as likable. In Study 1, younger children, unlike the older participants, liked and morally valued boasters who were accurate about their boasts. Justifications suggested the 5- to 7-year-olds perceived the boaster as sharing knowledge and being potentially helpful. No age group liked boasters who misrepresented themselves...
November 20, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/29153155/a-100-year-review-fat-feeding-of-dairy-cows
#13
D L Palmquist, T C Jenkins
Over 100 years, the Journal of Dairy Science has recorded incredible changes in the utilization of fat for dairy cattle. Fat has progressed from nothing more than a contaminant in some protein supplements to a valuable high-energy substitute for cereal grains, a valuable energy source in its own right, and a modifier of cellular metabolism that is under active investigation in the 21st century. Milestones in the use of fats for dairy cattle from 1917 to 2017 result from the combined efforts of noted scientists and industry personnel worldwide, with much of the research published in Journal of Dairy Science...
December 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29134858/ancel-benjamin-keys-1904-2004-his-early-works-and-the-legacy-of-the-modern-mediterranean-diet
#14
Basil H Aboul-Enein, William C Puddy, Joshua Bernstein
Culturally congruent dietary patterns have evolved with geographic and societal traditions and can be traced as far back as pre-Hellenistic Greece. Today, the modern Mediterranean diet (MDiet) is recognized internationally as an anti-obesogenic cardioprotective dietary model consisting of plant-based foods native to the Mediterranean basin, fish, olive oil, and an active lifestyle. With the assumption that obesity and heart disease rates adversely affected life expectancy, the MDiet was identified by Dr Ancel Keys as a primary characteristic among people-groups largely immune to these trends...
January 1, 2017: Journal of Medical Biography
https://www.readbyqxmd.com/read/29114436/preferred-names-preferred-pronouns-and-gender-identity-in-the-electronic-medical-record-and-laboratory-information-system-is-pathology-ready
#15
Katherine L Imborek, Nicole L Nisly, Michael J Hesseltine, Jana Grienke, Todd A Zikmund, Nicholas R Dreyer, John L Blau, Maia Hightower, Robert M Humble, Matthew D Krasowski
Background: Electronic medical records (EMRs) and laboratory information systems (LISs) commonly utilize patient identifiers such as legal name, sex, medical record number, and date of birth. There have been recommendations from some EMR working groups (e.g., the World Professional Association for Transgender Health) to include preferred name, pronoun preference, assigned sex at birth, and gender identity in the EMR. These practices are currently uncommon in the United States. There has been little published on the potential impact of these changes on pathology and LISs...
2017: Journal of Pathology Informatics
https://www.readbyqxmd.com/read/29105250/improved-enantioselectivity-of-subtilisin-carlsberg-towards-secondary-alcohols-by-protein-engineering
#16
Robin Dorau, Tamás Görbe, Maria Svedendahl Humble
Generally, the catalytic activity of subtilisin Carlsberg (SC) for transacylation reactions using secondary alcohols in organic solvent is low. Enzyme immobilization and protein engineering was performed to improve the enantioselectivity of SC towards secondary alcohols. Possible amino acid residues for mutagenesis were found by combining available literature data with molecular modeling. SC variants were created by site-directed mutagenesis and evaluated for a model transacylation reaction containing 1-phenylethanol in THF...
November 4, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29102012/editorial-commentary-you-may-not-have-seen-it-but-it-has-seen-you-diagnosis-of-long-head-biceps-tendon-and-subscapularis-pathology-in-association-with-shoulder-rotator-cuff-pathology-can-be-challenging
#17
EDITORIAL
Dan Guttmann
The shoulder can humble you. It is often challenging in determining the extent of pathology even when there is an adequate magnetic resonance imaging performed preoperatively and even during the so-called diagnostic portion of the arthroscopy. Abnormalities of the long head of the biceps tendon and the rotator cuff especially the subscapularis can be difficult to diagnose definitively. Experience can be very helpful in predicting pathology based on patterns seen before and knowing certain pearls that can make diagnosis and ultimately treatment more accurate...
November 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29094960/overconfidence-among-beginners-is-a-little-learning-a-dangerous-thing
#18
Carmen Sanchez, David Dunning
Across 6 studies we investigated the development of overconfidence among beginners. In 4 of the studies, participants completed multicue probabilistic learning tasks (e.g., learning to diagnose "zombie diseases" from physical symptoms). Although beginners did not start out overconfident in their judgments, they rapidly surged to a "beginner's bubble" of overconfidence. This bubble was traced to exuberant and error-filled theorizing about how to approach the task formed after just a few learning experiences...
November 2, 2017: Journal of Personality and Social Psychology
https://www.readbyqxmd.com/read/29073471/prediction-of-sub-surface-37-ar-concentrations-at-locations-in-the-northwestern-united-states
#19
Bradley G Fritz, Craig E Aalseth, Henning O Back, James C Hayes, Paul H Humble, Pavlo Ivanusa, Emily K Mace
The Comprehensive Nuclear-Test-Ban Treaty, which is intended to prevent nuclear weapon test explosions and any other nuclear explosions, includes a verification regime, which provides monitoring to identify potential nuclear explosions. The presence of elevated (37)Ar is one way to identify subsurface nuclear explosive testing. However, the naturally occurring formation of (37)Ar in the subsurface adds a complicating factor. Prediction of the naturally occurring concentration of (37)Ar can help to determine if a measured (37)Ar concentration is elevated relative to background...
October 23, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29065813/enter-as-an-outsider-teaching-organizational-humility
#20
John F Clabby
The concept of cultural humility acknowledges the enormous task of becoming culturally competent by encouraging curiosity about the context within which others live. For physicians, this includes curiosity about the organizations in which they work as Outsiders in settings such as a new hospital or patients' homes. However, efforts to train healthcare professionals in cultural competence are often de-emphasized due to the pressure learners feel to acquire Medical Knowledge and clinical skills. Little time is devoted to address the significance of cultural humility for fully appreciating the experiences of others...
May 2017: International Journal of Psychiatry in Medicine
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