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https://www.readbyqxmd.com/read/28547033/assessing-colorectal-cancer-knowledge-among-puerto-rican-hispanics-implications-for-cancer-prevention-and-control
#1
Reinaldo Ramírez-Amill, Marievelisse Soto-Salgado, Carla Vázquez-Santos, Mónica Corzo-Pedrosa, Marcia Cruz-Correa
In Puerto Rico, colorectal cancer (CRC) incidence and mortality rates are increasing. Moreover, adherence rates to CRC screening (52.2%) are still below the goals (70.5%) established by Healthy People 2020. Lack of knowledge is described as a significant barrier to adherence to CRC screening. The aim of this study was to assess CRC knowledge and screening rates among Puerto Rican Hispanics. Participants aged 40-85 years were recruited from the internal medicine outpatient clinics at the University of Puerto Rico...
May 25, 2017: Journal of Community Health
https://www.readbyqxmd.com/read/28545429/awareness-knowledge-perceptions-and-attitudes-towards-genetic-testing-for-cancer-risk-among-ethnic-minority-groups-a-systematic-review
#2
Katie E J Hann, Madeleine Freeman, Lindsay Fraser, Jo Waller, Saskia C Sanderson, Belinda Rahman, Lucy Side, Sue Gessler, Anne Lanceley
BACKGROUND: Genetic testing for risk of hereditary cancer can help patients to make important decisions about prevention or early detection. US and UK studies show that people from ethnic minority groups are less likely to receive genetic testing. It is important to understand various groups' awareness of genetic testing and its acceptability to avoid further disparities in health care. This review aims to identify and detail awareness, knowledge, perceptions, and attitudes towards genetic counselling/testing for cancer risk prediction in ethnic minority groups...
May 25, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28545182/breast-cancer-in-australian-indigenous-women-incidence-mortality-and-risk-factors
#3
Kriscia A Tapia, Gail Garvey, Mark Mc Entee, Mary Rickard, Patrick Brennan
The Indigenous people of Australia face significant health gaps compared with the general population, with lower life expectancies, higher rates of death, and chronic illness occurring more often than in non-indigenous Australians. Cancer is the second largest contributor to the burden of disease with breast cancer being the most common invasive cancer diagnosed for females. Despite a lower breast cancer incidence compared with non-indigenous women, fatalities occur at an elevated rate and breast cancers have an earlier age of onset...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28542894/risk-factors-of-falls-among-inpatients-with-cancer
#4
M D Jun, K M Lee, S A Park
AIM: To investigate the risk factors and predictors of falls according to the general characteristics, conscious state, physical condition and treatment of hospitalized patients with cancer. BACKGROUND: Inpatients with cancer experience falls more frequently than those without cancer, and the degree of injuries is more severe among inpatients with cancer. A specific fall prevention strategy is needed for each patient. Prevention of falls in patients with cancer is very important for improving the quality of nursing care...
May 25, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28542283/shared-susceptibility-loci-at-2q33-region-for-lung-and-esophageal-cancers-in-high-incidence-areas-of-esophageal-cancer-in-northern-china
#5
Xue Ke Zhao, Yi Min Mao, Hui Meng, Xin Song, Shou Jia Hu, Shuang Lv, Rang Cheng, Tang Juan Zhang, Xue Na Han, Jing Li Ren, Yi Jun Qi, Li Dong Wang
BACKGROUND: Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population. METHODS: A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China...
2017: PloS One
https://www.readbyqxmd.com/read/28542165/subtypes-of-native-american-ancestry-and-leading-causes-of-death-mapuche-ancestry-specific-associations-with-gallbladder-cancer-risk-in-chile
#6
Justo Lorenzo Bermejo, Felix Boekstegers, Rosa González Silos, Katherine Marcelain, Pablo Baez Benavides, Carol Barahona Ponce, Bettina Müller, Catterina Ferreccio, Jill Koshiol, Christine Fischer, Barbara Peil, Janet Sinsheimer, Macarena Fuentes Guajardo, Olga Barajas, Rolando Gonzalez-Jose, Gabriel Bedoya, Maria Cátira Bortolini, Samuel Canizales-Quinteros, Carla Gallo, Andres Ruiz Linares, Francisco Rothhammer
Latin Americans are highly heterogeneous regarding the type of Native American ancestry. Consideration of specific associations with common diseases may lead to substantial advances in unraveling of disease etiology and disease prevention. Here we investigate possible associations between the type of Native American ancestry and leading causes of death. After an aggregate-data study based on genome-wide genotype data from 1805 admixed Chileans and 639,789 deaths, we validate an identified association with gallbladder cancer relying on individual data from 64 gallbladder cancer patients, with and without a family history, and 170 healthy controls...
May 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28541788/addressing-hereditary-cancer-risk-at-the-end-of-life
#7
Eric J Roeland, Alexandra D Dullea, Chelsea H Hagmann, Lisa Madlensky
Oncology guidelines clearly outline evidence-based recommendations for patients with newly diagnosed cancer to help oncologists determine which patients are appropriate for a genetic assessment. Ideally, patients with newly diagnosed cancer, who have personal or family histories suggestive of hereditary cancer predisposition, are referred for genetics work up in the nonurgent setting. However, in some cases, a genetics work up is delayed until the end of life. This is a time of heightened stress and additional obstacles, including discordance between family members regarding the obtainment of genetic information, paying for testing, selecting a surrogate to receive and disperse information in the case of a patient's death, and the use of DNA banking for future evaluation...
May 25, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28539467/b7-h3-expression-in-nsclc-and-its-association-with-b7-h4-pd-l1-and-tumor-infiltrating-lymphocytes
#8
Mehmet Altan, Vasiliki Pelekanou, Kurt A Schalper, Maria I Toki, Patricia Gaule, Konstantinos N Syrigos, Roy S Herbst, David L Rimm
Background and Purpose: <p>The immune checkpoint PD-1 and its receptor B7-H1 (PD-L1) are successful therapeutic targets in cancer but less is known about other B7 family members.  Here, we determined the expression level of B7-H3 protein in non-small cell lung cancer (NSCLC) and evaluated its association with tumor infiltrating lymphocytes (TILs), PD-L1, B7-H4 and major clinico-pathological characteristics is in 3 NSCLC cohorts.</p> <p>Experimental design:</p> <p>We used multiplexed automated quantitative immunofluorescence (QIF) to assess the levels of B7-H3, PD-L1, B7-H4 and TILs in 634 NSCLC cases with validated antibodies...
May 24, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28539293/-comparison-of-risk-factors-for-serrated-polyps-and-conventional-adenoma-and-the-suitable-age-to-start-colorectal-cancer-screening
#9
Qian Dai, Jiang Liu, Mu-Xiao Zhong, Wei Zhu, Ya-Li Zhang
OBJECTIVE: To compare the risk factors associated with serrated polyps (SPs) and conventional adenoma (CA). METHODS: One hundred and three healthy control subjects, 100 patients with pathologically confirmed SPs and 115 with CA were randomly selected from individuals undergoing colonoscopy in Nanfang Hospital from 2012 to 2015. The demographic and clinical data were collected from the subjects, including age, gender, height, weight, hypertension, diabetes, smoking status, alcohol use, family history of colorectal cancer (CRC) and blood lipids...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28539235/multi-institutional-evaluation-of-women-at-high-risk-of-developing-breast-cancer
#10
David J Hermel, Marie E Wood, Jennifer Chun, Tiffany Rounds, Melissa Sands, Shira Schwartz, Freya R Schnabel
INTRODUCTION: We performed the present study to better understand the practices and preferences of women with an elevated risk of breast cancer by merging the registries from 2 separate institutions and comparing the clinical characteristics and outcomes. MATERIALS AND METHODS: The data from women enrolled in institutional review board-approved registries from 2003 to 2015 at the New York University Langone Medical Center and University of Vermont Medical Center were evaluated...
April 14, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/28532339/mediators-of-a-physical-activity-intervention-among-women-with-a-family-history-of-breast-cancer
#11
Catherine R Marinac, Shira I Dunsiger, Bess H Marcus, Rochelle K Rosen, Kim M Gans, Sheri J Hartman
The current study examined mediators of an efficacious physical activity intervention. Women with a mean age of 46.2 (range 23-61) years and a family history of breast cancer were randomized to either an Internet-based physical activity intervention (n = 28) or an active control condition (n = 27) for three months. Data were collected between November 2010 and August 2011. Hypothesized mediators were examined using a product of coefficients model with bootstrapped standard errors. Significant mediation was observed for both self-efficacy and behavioral processes...
May 22, 2017: Women & Health
https://www.readbyqxmd.com/read/28529023/clinical-efficacy-of-transrectal-ultrasound-guided-prostate-biopsy-in-men-younger-than-50-years-old-with-an-elevated-prostate-specific-antigen-concentration-4-0%C3%A2-ng-ml
#12
Chin-Heng Lu, Tzu-Ping Lin, She Huei Shen, Yi-Hsiu Huang, Hsiao-Jen Chung, Junne-Yih Kuo, William J S Huang, Howard H H Wu, Yen-Hwa Chang, Alex T L Lin, Kuang-Kuo Chen
BACKGROUND: Prostate cancer (PCa) is not commonly found in men younger than 50 years of age. However, serum prostate-specific antigen (PSA) concentration has been examined more frequently at a younger age in Asia partially due to an increased awareness of prostate cancer. The purpose of our study was to investigate the efficacy and complication of PSA-triggered transrectal ultrasonography-guided prostate (TRUSP) biopsies. We retrospectively reviewed TRUSP biopsies in young men with elevated PSA concentration in Taipei Veterans General Hospital...
May 18, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28529006/validation-of-a-next-generation-sequencing-pipeline-for-the-molecular-diagnosis-of-multiple-inherited-cancer-predisposing-syndromes
#13
Paula Paulo, Pedro Pinto, Ana Peixoto, Catarina Santos, Carla Pinto, Patrícia Rocha, Isabel Veiga, Gabriela Soares, Catarina Machado, Fabiana Ramos, Manuel R Teixeira
Despite the growing knowledge of the genetic background behind the cancers that occur in a context of hereditary predisposition, personal or family cancer history may not be clear enough to support directional gene testing. Defined targeted next-generation sequencing gene panels allow identification of the causative disease mutations of multigene syndromes and differential diagnosis for syndromes with phenotypically overlapping characteristics. Herein, we established a next-generation sequencing analysis pipeline for the molecular diagnosis of multiple inherited cancer predisposing syndromes using the commercially available target sequencing panel TruSight Cancer...
May 18, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28528517/loss-of-msh2-and-msh6-due-to-heterozygous-germline-defects-in-msh3-and-msh6
#14
Monika Morak, Sarah Käsbauer, Martina Kerscher, Andreas Laner, Anke M Nissen, Anna Benet-Pagès, Hans K Schackert, Gisela Keller, Trisari Massdorf, Elke Holinski-Feder
Lynch Syndrome (LS) is the most common dominantly inherited colorectal cancer (CRC) predisposition and is caused by a heterozygous germline defect in one of the DNA mismatch repair (MMR) genes MLH1, MSH2, MSH6, or PMS2. High microsatellite instability (MSI-H) and loss of MMR protein expression in tumours reflecting a defective MMR are indicators for LS, as well as a positive family history of early onset CRC. MSH2 and MSH6 form a major functional heterodimer, and MSH3 is an alternative binding partner for MSH2...
May 20, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28528448/prostate-cancer-related-anxiety-in-long-term-survivors-after-radical-prostatectomy
#15
Valentin H Meissner, Kathleen Herkommer, Birgitt Marten-Mittag, Jürgen E Gschwend, Andreas Dinkel
PURPOSE: Knowledge of the psychological distress of long- and very long-term (>10 years) prostate cancer (PC) survivors is limited. This study intended to examine the parameters influencing anxiety related to prostate-specific antigen (PSA) and PC in long-term survivors after radical prostatectomy. METHODS: We surveyed 4719 PC survivors from the German multicenter prospective database "Familial Prostate Cancer." We evaluated the association of PC-related anxiety (MAX-PC) with sociodemographic characteristics, family history of PC, global health status/quality of life (EORTC QLQ-C30), depression and anxiety (PHQ-2; GAD-2), latest PSA level, time since radical prostatectomy, and current therapy...
May 21, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28527397/mri-surveillance-for-women-with-dense-breasts-and-a-previous-breast-cancer-and-or-high-risk-lesion
#16
Michelle Nadler, Hyder Al-Attar, Ellen Warner, Anne L Martel, Sharmila Balasingham, Liying Zhang, Joseph H Lipton, Belinda Curpen
BACKGROUND: The role of surveillance breast MRI for women with mammographically dense breasts, a personal history of breast cancer (BC), atypical hyperplasia (AH), or lobular carcinoma in situ (LCIS) is unclear. We estimated the performance of annual surveillance MRI in women with a combination of these risk factors. METHODS: We performed a retrospective review of the clinical, radiological, and pathological parameters of women who received annual concurrent surveillance breast MRI and mammography between 04/2013 and 12/2015 and fulfilled all of the following criteria: 1) age <70; 2) prior diagnosis of AH, LCIS or BC; 3) heterogeneously or extremely dense breast(s); and 4) did not qualify for our provincial breast MRI high risk screening program...
May 17, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28526031/breast-cancer-relatives-physical-activity-intervention-needs-and-preferences-qualitative-results
#17
Sheri J Hartman, Rochelle K Rosen
BACKGROUND: While many risk factors for breast cancer, such as family history, are not modifiable, some, however, can be modified. The study used formative qualitative research to learn about the physical activity intervention preferences and needs of first-degree female relatives (FDFRs) of breast cancer patients; that information was then used to develop a targeted physical activity intervention. METHODS: Twenty FDFRs first completed a 12-week physical activity intervention and then attended two sequential focus groups (7 groups total)...
May 19, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28523262/case-report-of-menopausal-woman-diagnosed-with-endometrial-cancer-after-colon-cancer-with-germline-mutation-in-msh6-in-korea
#18
Hyun Jung Lee, Min Hee Lee, Min Chul Choi, Sang Geun Jung, Won Duk Joo, Tae Hoen Kim, Chan Lee, Ja-Hyun Jang
We present a case of an endometrial cancer patient with germline mutation in MutS homolog 6 (MSH6), associated with Lynch syndrome. A 60-year-old Korean woman had a personal history of colon cancer 23 years ago. She also had a family history of endometrial cancer and colon cancer of her sisters and brothers. Immunohistochemistry was negative for MutL homolog 1 (MLH1) and positive for MutS homolog 2 (MSH2). Based on these findings, she underwent genetic counseling and testing that revealed a frameshift germline mutation at MSH6 (c...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28522950/red-flag-symptoms-detailed-account-of-clinicopathological-features-in-young-onset-colorectal-cancer
#19
Ramish Riaz, Nosheen Masood, Arfa Benish
BACKGROUND/AIMS: Colorectal cancer has long been considered disease of the West, typically occurring in old age; however, the incidence is rising in Asia. The pattern of disease is quite different in Asia, occurring at a younger age and at an advanced stage. Recognition of disease at an early stage is still a challenge for physicians. Few data are available regarding young-onset colorectal cancer in Pakistan. We conducted this study to fill this gap and provide deeper insight into clinical symptoms and histopathological features of young-onset colorectal cancer...
April 2017: Intestinal Research
https://www.readbyqxmd.com/read/28521362/association-of-common-genetic-variants-with-contralateral-breast-cancer-risk-in-the-wecare-study
#20
Mark E Robson, Anne S Reiner, Jennifer D Brooks, Patrick J Concannon, Esther M John, Lene Mellemkjaer, Leslie Bernstein, Kathleen E Malone, Julia A Knight, Charles F Lynch, Meghan Woods, Xiaolin Liang, Robert W Haile, David J Duggan, Roy E Shore, Susan A Smith, Duncan C Thomas, Daniel O Stram, Jonine L Bernstein
Background: Women with unilateral breast cancer (UBC) are at risk of developing a subsequent contralateral breast cancer (CBC). Common variants are associated with breast cancer risk. Whether these influence CBC risk is unknown. Methods: Participants were breast cancer cases from the population-based Women's Environmental Cancer and Radiation Epidemiology (WECARE) Study. Sixty-seven established breast cancer risk loci were genotyped directly or by imputation in 1459 case subjects with CBC and 2126 UBC control subjects...
October 1, 2017: Journal of the National Cancer Institute
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