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Colorectal polyps

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https://www.readbyqxmd.com/read/29353151/the-association-between-recreational-physical-activity-sedentary-time-and-colorectal-polyps-in-a-population-screened-for-colorectal-cancer
#1
Darren R Brenner, Eileen Shaw, Demetra H Yannitsos, Matthew T Warkentin, Nigel T Brockton, S Elizabeth McGregor, Susanna Town, Robert J Hilsden
PURPOSE: Regular recreational moderate to vigorous physical activity (rMVPA) has been previously associated with a reduced risk of colorectal cancer (CRC), however, few studies have examined the association of rMVPA with colorectal polyps, the pre-malignant precursor lesions. The objective of this study was to examine the associations between physical activity and sitting time and polyps at the time of screening. METHODS: We conducted a cross-sectional study of 2496 individuals undergoing screening-related colonoscopy in Calgary, Alberta, Canada...
January 17, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29351808/clinicopathologic-features-of-colorectal-carcinoma-features-predicting-higher-t-stage-and-nodal-metastasis
#2
Atif Ali Hashmi, Shumaila Kanwal Hashmi, Navaira Ali, Komal Thara, Rabia Ali, Muhammad Muzzammil Edhi, Naveen Faridi, Amir Khan
OBJECTIVES: A rising frequency of colorectal carcinoma has been noted in recent years in Pakistan. In the present study, we aimed to evaluate clinicopathologic features of colorectal carcinoma in our population so that protocols could be developed to stratify patients that may require further biomarker/molecular testing. Furthermore, histological features which predict higher T and N stage were also evaluated. RESULTS: Median age at diagnosis was 54.5 (19-85) years...
January 19, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29344790/prospective-analysis-of-delayed-colorectal-post-polypectomy-bleeding
#3
Soo-Kyung Park, Jeong Yeon Seo, Min-Gu Lee, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Hungdai Kim, Hyung Ook Kim, Kyung Uk Jung, Ho-Kyung Chun, Dong Il Park
BACKGROUNDS/AIMS: Although post-polypectomy bleeding is the most frequent complication after colonoscopic polypectomy, only few studies have investigated the incidence of bleeding prospectively. The aim of this study was to investigate the incidence of delayed post-polypectomy bleeding and its associated risk factors prospectively. METHODS: Patients who underwent colonoscopic polypectomy at Kangbuk Samsung Hospital from January 2013 to December 2014 were prospectively enrolled in this study...
January 17, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29344228/expression-and-clinical-significance-of-atm-and-puma-gene-in-patients-with-colorectal-cancer
#4
Hui Xiong, Jiangnan Zhang
The expression of ataxia-telangiectasia mutated (ATM) and p53 upregulated modulator of apoptosis (PUMA) genes in patients with colorectal cancer were investigated, to explore the correlation between the expression of ATM and PUMA and tumor development, to evaluate the clinical significance of ATM and PUMA in the treatment of colorectal cancer. Quantitative real-time PCR was used to detect the expression of ATM and PUMA in tumor tissue and adjacent healthy tissue of 67 patients with colorectal cancer and in normal colorectal tissue of 33 patients with colorectal polyps at mRNA level...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29339485/elevated-d-2-hydroxyglutarate-during-colitis-drives-progression-to-colorectal-cancer
#5
Jie Han, Dakota Jackson, Janette Holm, Kevin Turner, Paula Ashcraft, Xuan Wang, Beth Cook, Erland Arning, Robert M Genta, K Venuprasad, Rhonda F Souza, Lawrence Sweetman, Arianne L Theiss
d-2-hydroxyglutarate (D2HG) is produced in the tricarboxylic acid cycle and is quickly converted to α-ketoglutarate by d-2-hydroxyglutarate dehydrogenase (D2HGDH). In a mouse model of colitis-associated colon cancer (CAC), urine level of D2HG during colitis correlates positively with subsequent polyp counts and severity of dysplasia. The i.p. injection of D2HG results in delayed recovery from colitis and severe tumorigenesis. The colonic expression of D2HGDH is decreased in ulcerative colitis (UC) patients at baseline who progress to cancer...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29334136/a-bayesian-network-meta-analysis-efficacy-of-air-insufflation-co2-insufflation-water-exchange-and-water-immersion-in-colonoscopy
#6
REVIEW
Zhen Zhang, Yifeng Wu, Guangge Sun, Jing Zhang, Jiaxin Li, Chongyang Qiu, Xin Zheng, Botao Wang, Lei Yang, Ximo Wang
BACKGROUND: Colonoscopy is one of the excellent tools for screening colorectal cancer. There were four colonoscopy techniques containing air insufflation, CO2 insufflation, water exchange, and water immersion. Some studies reported that these methods are better than the criterion standard (air insufflation), while some studies showed not. In order to evaluate the efficacy of four colonoscopy techniques, a network meta-analysis was performed in present study. METHODS: We searched randomized controlled trials (RCTs) published up to September 2017 from PubMed, Embase, Cochrane library, and Web of Science...
January 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29333424/anatomical-distribution-and-detection-rate-of-colorectal-neoplasms-according-to-age-in-the-colonoscopic-screening-of-a-korean-population
#7
Suk-Young Lee, Wan Hee Song, Sang Cheul Oh, Byung-Wook Min, Sun Il Lee
Purpose: Because data as a basis for the determination of proper age and modality for screening of colorectal neoplasms is lacking, we evaluated detection rates and anatomical distribution of colorectal neoplasms according to age in healthy individuals who underwent total colonoscopy for health checkup. Methods: A total of 16,100 cases that had received the colonoscopic examination from January to December in 2014 were analyzed. The total number of individuals who received total colonoscopy were divided by the number of individuals harboring colorectal adenoma to calculate the detection rate of colorectal adenoma...
January 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29324674/calcitriol-supplementation-causes-decreases-in-tumorigenic-proteins-and-different-proteomic-and-metabolomic-signatures-in-right-versus-left-sided-colon-cancer
#8
Monica M Schroll, Katelyn R Ludwig, Kerry M Bauer, Amanda B Hummon
Vitamin D deficiency is a common problem worldwide. In particular, it is an issue in the Northern Hemisphere where UVB radiation does not penetrate the atmosphere as readily. There is a correlation between vitamin D deficiency and colorectal cancer incidence and mortality. Furthermore, there is strong evidence that cancer of the ascending (right side) colon is different from cancer of the descending (left side) colon in terms of prognosis, tumor differentiation, and polyp type, as well as at the molecular level...
January 11, 2018: Metabolites
https://www.readbyqxmd.com/read/29324375/cancer-in-an-unexpected-site-post-pouch-surgery-for-familial-adenomatous-polyposis-fap
#9
Omar A Alwahbi, Alaa S Abduljabbar, Lucman A Anwer
INTRODUCTION: Familial Adenomatous Polyposis (FAP) is a hereditary condition characterized by multiple colorectal adenomatous polyps. FAP is the most common adenomatous polyposis syndrome. Restorative proctocolectomy is the most commonly performed surgical procedure performed for patients suffering from FAP with different options for anastomosis, namely ileorectal anastomosis (IRA) or ileal pouch anal anastomosis (IPAA). The occurrence of adenomas is a common finding during follow up and surveillance post surgery for these patients...
December 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29323753/associations-of-mitochondrial-polymorphisms-with-sporadic-colorectal-adenoma
#10
Bharat Thyagarajan, Weihua Guan, Veronika Fedirko, Helene Barcelo, Ramya Ramasubramaian, Myron Gross, Michael Goodman, Roberd M Bostick
Somatic mutations in mitochondrial DNA have been reported in colorectal adenomatous polyps (adenomas), the precursors to most colorectal cancers. However, there are no reports of associations of germline variation in mitochondrial DNA with adenoma risk. We investigated associations of germline polymorphisms in the displacement loop (D-loop) and non-D-loop region of the mitochondrial genome with incident, sporadic colorectal adenoma in three pooled colonoscopy-based case-control studies (n = 327 adenoma cases, 420 controls) that used identical methods for case and risk factor ascertainment...
January 11, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29317277/increasing-rates-of-surgery-for-patients-with-non-malignant-colorectal-polyps-in-the-united-states
#11
Anne F Peery, Katherine S Cools, Paula D Strassle, Sarah K McGill, Seth D Crockett, Aubrey Barker, Mark Koruda, Ian S Grimm
BACKGROUND & AIMS: Despite the availability of endoscopic therapy, many patients in the United States undergo surgical resection for non-malignant colorectal polyps. We aimed to quantify and examine trends in the use of surgery for non-malignant colorectal polyps in a nationally representative sample. METHODS: We analyzed data from the Healthcare Cost and Utilization Project National Inpatient Sample for the years 2000 through 2014. We included all adult patients who underwent elective colectomy or proctectomy and had a diagnosis of either non-malignant colorectal polyp or colorectal cancer...
January 6, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29308085/could-mycobacterium-avium-subspecies-paratuberculosis-cause-crohn-s-disease-ulcerative-colitis%C3%A2-and-colorectal-cancer
#12
Ellen S Pierce
Infectious agents are known causes of human cancers. Schistosoma japonicum and Schistosoma mansoni cause a percentage of colorectal cancers in countries where the respective Schistosoma species are prevalent. Colorectal cancer is a complication of ulcerative colitis and colonic Crohn's disease, the two main forms of idiopathic inflammatory bowel disease (IIBD). Mycobacterium avium subspecies paratuberculosis (MAP), the cause of a chronic intestinal disease in domestic and wild ruminants, is one suspected cause of IIBD...
2018: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/29301746/cyclic-gmp-elevating-agents-suppress-polyposis-in-apc-min-mice-by-targeting-the-preneoplastic-epithelium
#13
Sarah K Sharman, Bianca N Islam, Yali Hou, Nagendra Singh, Franklin G Berger, Subbaramiah Sridhar, Wonsuk Yoo, Darren D Browning
The cGMP signaling axis has been implicated in the suppression of intestinal cancers but the inhibitory mechanism and the extent to which this pathway can be targeted remains poorly understood. The present study has tested the effect of cGMP-elevating agents on tumorigenesis in the ApcMin/+ mouse model of intestinal cancer. Treatment of ApcMin/+ mice with the receptor guanylyl-cyclase C (GCC) agonist linaclotide, or the phosphodiesterase-5 (PDE5) inhibitor sildenafil, significantly reduced the number of polyps per mouse (67% and 50% respectively)...
January 4, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29298873/multicentre-prospective-evaluation-of-real-time-optical-diagnosis-of-t1-colorectal-cancer-in-large-non-pedunculated-colorectal-polyps-using-narrow-band-imaging-the-optical-study
#14
Yara Backes, Matthijs P Schwartz, Frank Ter Borg, Frank H J Wolfhagen, John N Groen, Wouter H de Vos Tot Nederveen Cappel, Jeroen van Bergeijk, Joost M J Geesing, Bernhard W M Spanier, Paul Didden, Frank P Vleggaar, Miangela M Lacle, Sjoerd G Elias, Leon M G Moons
OBJECTIVE: This study evaluated the preresection accuracy of optical diagnosis of T1 colorectal cancer (CRC) in large non-pedunculated colorectal polyps (LNPCPs). DESIGN: In this multicentre prospective study, endoscopists predicted the histology during colonoscopy in consecutive patients with LNPCPs using a standardised procedure for optical assessment. The presence of morphological features assessed with white light, and vascular and surface pattern with narrow-band imaging (NBI) were recorded, together with the optical diagnosis, the confidence level of prediction and the recommended treatment...
January 3, 2018: Gut
https://www.readbyqxmd.com/read/29283904/role-of-full-spectrum-endoscopy-in-colorectal-cancer-screening-randomized-trial
#15
Henar Núñez-Rodríguez, Pilar Diez-Redondo, Manuel Pérez-Miranda, Manuel Gonzalez Sagrado, Rosa Conde, Carlos De la Serna
GOALS: The aim of this study was to compare a new, full-spectrum endoscope (Fuse; EndoChoice, Alpharetta, GA) to standard forward-viewing colonoscopy in the detection of colorectal neoplasms. BACKGROUND: Colonoscopy, the gold standard for the detection of colorectal cancer, fails to detect 22% to 28% of polyps, increasing the risk of interval cancer. Endoscopic improvement of the adenoma detection rate decrease interval carcinomas. Full-spectrum endoscopy (FUSE) (330-degree field of view), in a tandem study, has been shown to reduce the adenoma miss rate...
December 27, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29280125/-pediatric-colonoscopy-in-south-china-a-single-center-experience-from-229-cases
#16
Jinhua Chen, Huichuan Yu, Weijie Zhong, Honglei Chen, Xianhe Kong, Jiachen Sun, Xiaolin Wang, Chujun Li
OBJECTIVE: To investigate the safety, feasibility, clinical value, indication, and distribution of diagnostic diseases in different age groups of colonoscopy in pediatric patients. METHODS: A retrospective analysis was performed on the data of pediatric patients receiving colonoscopy from April 2013 to June 2016 at The Sixth Affiliated Hospital of Sun Yat-sen University. Pediatric patients were divided into 0-6 years group (n=57) and 7-14 years group (n=172). Indication for colonoscopy, detective events and diagnostic diseases distribution were compared between two groups...
December 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29278867/optical-diagnosis-for-colorectal-polyps-a-useful-technique-now-or-in-the-future
#17
REVIEW
Ignasi Puig, Tonya Kaltenbach
In the last few years, interest in the optical diagnosis of colorectal polyps has increased among gastroenterologists. Several studies have shown that the optical diagnosis of small colorectal polyps is safe and feasible in routine clinical practice and is comparable to histopathology. The Narrow-band Imaging International Colorectal Endoscopic Classification provides a validated criterion for the classification of neoplastic and nonneoplastic polyps as well as polyps with deep submucosal invasion using narrow band imaging during real-time colonoscopy...
December 28, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29278636/immunohystochemical-expression-of-vitamin-d-receptor-in-development-stages-of-colorectal-carcinoma
#18
Nikica Šutalo, Snježana Tomić, Milenko Bevanda, Vedran Dragišić, Inga Marijanović, Joško Petričević, Ivanka Mikulić
BACKGROUND: Chemo preventive and antitumor role of vitamin D is manifested through genetic and non genetic ways with a powerful antproliferatory and proapopoptic effect, which is proven by numerous epidemiologic studies. The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. VDR in tissue cells is present in the cytoplasm and the nucleus and manifests its genetic activity after transfer from the cytoplasm to the nucleus...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29277562/evaluating-the-expression-level-of-co-stimulatory-molecules-cd-80-and-cd-86-in-different-types-of-colon-polyps
#19
N Peyravian, E Gharib, A Moradi, M Mobahat, P Tarban, P Azimzadeh, E Nazemalhosseini-Mojarad, H Asadzadeh Aghdaei
PURPOSE OF THE STUDY: Co-stimulatory molecules CD80 and CD86 are the members of B7 family, which stimulate the T lymphocytes in response to the malignant colon polyps. However, the expression of these molecules is depressed in cancers. In the present study, the transcription levels of CD80 and CD86 genes in the colon polyps (Precancerous lesions) and its association with the clinical features were examined. PATIENTS AND METHODS: Forty-nine biopsies samples from patients with the colorectal polyps and 10 healthy subjects were collected by the colonoscopy...
December 22, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29276220/metachronous-neoplasia-and-local-recurrence-after-colorectal-endoscopic-submucosal-dissection
#20
Daisuke Takei, Keita Harada, Shiho Takashima, Toshihiro Inokuchi, Asuka Nakarai, Yusaku Sugihara, Masanobu Takahara, Sakiko Hiraoka, Hiroyuki Okada
Several reports discussed colonoscopic surveillance after polypectomy and endoscopic mucosal resection (EMR) for colorectal polyps, but only a few reports focused on prognostic analyses, and none involved metachronous neoplasia after colorectal endoscopic submucosal dissection (ESD). We conducted the present study to assess the risk of adenoma recurrence requiring endoscopic treatment, and to establish appropriate post-ESD colonoscopic surveillance. We enrolled 116 patients who had undergone colorectal ESD at Okayama University Hospital between February 2008 and July 2014 and had been followed-up >12 months...
December 2017: Acta Medica Okayama
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