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Colorectal polyps

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https://www.readbyqxmd.com/read/29785123/leucine-rich-alpha-2-glycoprotein-1-is-up-regulated-in-colorectal-cancer-and-is-a-tumor-promoter
#1
Qian Zhang, Rui Huang, Qingchao Tang, Yang Yu, Quanlong Huang, Yinggang Chen, Guiyu Wang, Xishan Wang
Background: Leucine-rich α-2-glycoprotein-1 (LRG1) is differentially expressed in many kinds of diseases including cancer, however, it has not been thoroughly studied yet. Purpose: The objective of this study was to detect the expression and potential mechanism of LRG1 in colorectal cancer (CRC). In our study, we examined LRG1 levels in CRC tissue and plasma with quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29780602/screening-for-colorectal-cancer-in-tianhe-guangzhou-results-of-combining-fecal-immunochemical-tests-and-risk-factors-for-selecting-patients-requiring-colonoscopy
#2
Yi Liao, Senmao Li, Chunyu Chen, Xuan He, Feng Lin, Jianping Wang, Zuli Yang, Ping Lan
Objective: To explore the performance of a protocol combining fecal immunochemical test (FIT) and a high-risk factor questionnaire (HRFQ) for selecting patients requiring colonoscopy as part of a population-based colorectal cancer (CRC) screening program in China. Methods: From 2015 to 2016, we conducted a CRC screening program for all residents aged 45 years or older in Tianhe District, Guangzhou City, China. Participants underwent an FIT and received an HRFQ as part of primary screening...
May 2018: Gastroenterology Report
https://www.readbyqxmd.com/read/29776633/molecular-diagnostics-in-colorectal-carcinoma-advances-and-applications-for-2018
#3
REVIEW
Amarpreet Bhalla, Muhammad Zulfiqar, Martin H Bluth
The molecular pathogenesis and classification of colorectal carcinoma are based on the traditional adenomaecarcinoma sequence, serrated polyp pathway, and microsatellite instability (MSI). The genetic basis for hereditary nonpolyposis colorectal cancer is the detection of mutations in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Genetic testing for Lynch syndrome includes MSI testing, methylator phenotype testing, BRAF mutation testing, and molecular testing for germline mutations in MMR genes. Molecular makers with predictive and prognostic implications include quantitative multigene reverse transcriptase polymerase chain reaction assay and KRAS and BRAF mutation analysis...
June 2018: Clinics in Laboratory Medicine
https://www.readbyqxmd.com/read/29774161/endoscopic-full-thickness-resection-eftr-of-colorectal-neoplasms-with-the-full-thickness-resection-device-ftrd-clinical-experience-from-two-tertiary-referral-centers-in-switzerland
#4
Patrick Aepli, Dominique Criblez, Stephan Baumeler, Jan Borovicka, Remus Frei
Background: Endoscopic full thickness resection (EFTR) by the Full Thickness Resection Device (FTRD) has recently been introduced as a method to allow resection of certain lesions such as adenomatous polyps that would not be resectable by standard polypectomy techniques. We report our clinical experience with FTRD procedures, assessing technical success, completeness of resection (R0 status), rate of histologically proven FTR and safety. Patients and methods: We conducted a retrospective analysis of 33 consecutive patients with colonic polyps treated with FTRD from May 2015 to November 2016...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29774160/underwater-endoscopic-colorectal-polyp-resection-feasibility-in-everyday-clinical-practice
#5
Sergio Cadoni, Mauro Liggi, Paolo Gallittu, Donatella Mura, Lorenzo Fuccio, Malcolm Koo, Sauid Ishaq
Background: Endoscopic mucosal resection is well-established for resecting flat or sessile benign colon polyps. The novel underwater endoscopic mucosal resection eschews submucosal injection prior to endoscopic mucosal resection. Reports about underwater endoscopic mucosal resection were limited to small series of single and/or tertiary-care referral centers, with single or supervised operators. Objective: The purpose of this study was to determine feasibility and efficacy of underwater resection of polyps of any morphology (underwater polypectomy, here includes underwater endoscopic mucosal resection) in routine clinical practice...
April 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29772067/dna-content-analysis-of-colorectal-serrated-lesions-detects-an-aneuploid-subset-of-inflammatory-bowel-disease-associated-serrated-epithelial-change-and-traditional-serrated-adenomas
#6
Won-Tak Choi, Kwun Wah Wen, Peter S Rabinovitch, Danning Huang, Aras N Mattis, Ryan M Gill
AIMS: Serrated lesions (SLs), including sessile serrated adenoma (SSA) and traditional serrated adenoma (TSA), are important premalignant lesions for colorectal cancer (CRC). Although a small subset of SLs are known to harbor TP53 mutations and Wnt/β-catenin pathway activation, suggesting that they may develop dysplasia or CRC via a 'chromosomal instability (CIN)-like' pathway, it is unclear if aneuploidy (characteristic of conventional adenoma) ever develops in SLs and is associated with development of dysplasia or CRC, in this context...
May 17, 2018: Histopathology
https://www.readbyqxmd.com/read/29768508/i-scan-optical-enhancement-for-the-in-vivo-prediction-of-diminutive-colorectal-polyp-histology-results-from-a-prospective-three-phased-multicentre-trial
#7
Entcho Klenske, Steffen Zopf, Clemens Neufert, Andreas Nägel, Jürgen Siebler, Jürgen Gschossmann, Steffen Mühldorfer, Lukas Pfeifer, Sarah Fischer, Francesco Vitali, Marietta Iacucci, Subrata Ghosh, Michelle G Rath, Peter Klare, Gian E Tontini, Markus F Neurath, Timo Rath
BACKGROUND AND AIMS: Dye-less chromoendoscopy is an emerging technology for colorectal polyp characterization. Herein, we investigated whether the newly introduced I-scan optical enhancement (OE) can accurately predict polyp histology in vivo in real-time. METHODS: In this prospective three-phased study, 84 patients with 230 diminutive colorectal polyps were included. During the first two study phases, five endoscopists assessed whether analysis of polyp colour, surface and vascular pattern under i-scan OE can differentiate in vivo between adenomatous and hyperplastic polyps...
2018: PloS One
https://www.readbyqxmd.com/read/29766397/novel-variant-of-unknown-significance-in-mutyh-in-a-patient-with-mutyh-associated-polyposis-a-case-to-reclassify
#8
Trilokesh D Kidambi, Dena Goldberg, Robert Nussbaum, Amie Blanco, Sarah E Umetsu, Jonathan P Terdiman, Jeffrey K Lee
MUTYH-associated polyposis (MAP) is a hereditary cancer syndrome that is caused by biallelic pathogenic variants in the MUTYH gene and should be evaluated for in patients with an attenuated colonic polyposis phenotype. Monoallelic pathogenic variants in MUTYH are associated with a moderate increased risk of colorectal cancer but not with the polyposis phenotype. We present a case of a patient presenting with multiple colonic adenomatous polyps, whose germline testing revealed a heterozygous pathogenic variant in MUTYH in exon 13, c...
May 15, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29765552/higher-enterococcus-counts-indicate-a-lower-risk-of-colorectal-adenomas-a-prospective-cohort-study
#9
Atsuko Kawano, Hideki Ishikawa, Michihiro Mutoh, Hiroyuki Kubota, Kazunori Matsuda, Hirokazu Tsuji, Kazumasa Matsumoto, Koji Nomoto, Ryuichiro Tanaka, Tomiyo Nakamura, Keiji Wakabayashi, Toshiyuki Sakai
Intestinal bacteria play an important role in human health. This prospective cohort study aimed to investigate the relationship between the abundance of different intestinal bacteria and the risk of developing colorectal cancer (CRC). Fecal samples from CRC patients ( n = 157) were collected at the start of the study wherein patients subsequently underwent endoscopy to remove polyps. Gut bacteria were isolated by using specific culture methods and the fecal counts of various bacteria were quantified by reverse-transcription-quantitative-PCR (RT-qPCR) assays...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29763272/colorectal-cancer-screening-and-prevention
#10
Thad Wilkins, Danielle McMechan, Asif Talukder
Colorectal cancer is a common cause of morbidity and mortality in the United States. Most colorectal cancers arise from preexisting adenomatous or serrated polyps. The incidence and mortality of colorectal cancer can be reduced with screening of average-risk adults 50 to 75 years of age. Randomized controlled trials show evidence of reduced colorectal cancer-specific mortality with guaiac-based fecal occult blood tests and flexible sigmoidoscopy. There are no randomized controlled trials on the effectiveness of colonoscopy to reduce colorectal cancer-specific mortality; however, several randomized controlled trials comparing colonoscopy with other strategies are in progress...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29761359/ct-colonography-size-reduction-of-submerged-colorectal-polyps-due-to-electronic-cleansing-and-ct-window-settings
#11
Christian Bräuer, Philippe Lefere, Stefaan Gryspeerdt, Helmut Ringl, Ali Al-Mukhtar, Paul Apfaltrer, Dominik Berzaczy, Barbara Füger, Julia Furtner, Christina Müller-Mang, Matthias Pones, Martina Scharitzer, Ramona Woitek, Anno Graser, Michael Weber, Thomas Mang
OBJECTIVES: To assess whether electronic cleansing (EC) of tagged residue and different computed tomography (CT) windows influence the size of colorectal polyps in CT colonography (CTC). METHODS: A database of 894 colonoscopy-validated CTC datasets of a low-prevalence cohort was retrospectively reviewed to identify patients with polyps ≥6 mm that were entirely submerged in tagged residue. Ten radiologists independently measured the largest diameter of each polyp, two-dimensionally, before and after EC in colon, bone, and soft-tissue-windows, in randomised order...
May 14, 2018: European Radiology
https://www.readbyqxmd.com/read/29756208/impact-of-loss-of-function-mutations-at-the-rnf43-locus-on-colorectal-cancer-development-and-progression
#12
Tsugio Eto, Keisuke Miyake, Katsuhiko Nosho, Masaki Ohmuraya, Yu Imamura, Kota Arima, Shinichi Kanno, Lingfeng Fu, Yuki Kiyozumi, Daisuke Izumi, Hidetaka Sugihara, Yukiharu Hiyoshi, Yuji Miyamoto, Hiroshi Sawayama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Toru Furukawa, Kimi Araki, Hideo Baba, Takatsugu Ishimoto
RNF43 mutations are frequently detected in colorectal cancer cells and lead to a loss of function of the ubiquitin E3 ligase. Here, we investigated the clinical significance of RNF43 mutations in a large Japanese cohort and the role of RNF43 at various stages of colorectal cancer development and progression. Mutation analysis of the RNF43 gene locus using pyrosequencing technology detected RNF43 hotspot mutations in 1 (0.88%) of 113 colorectal polyp cases and 30 (6.45%) of 465 colorectal cancer cases. Moreover, patients with colorectal cancer harboring mutated RNF43 experienced a higher recurrence rate than those harboring non-mutated RNF43...
May 13, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29756103/factors-affecting-successful-colonoscopy-procedures-single-center-experience
#13
Ramazan Kozan, Tonguç Utku Yılmaz, Uygar Baştuğral, Umut Kerimoğlu, Yücel Yavuz
Objective: Colonoscopy is a gold standard procedure for several colon pathologies. Successful colonoscopy means demonstration of the ileocecal valve and determination of colon polyps. Here we aimed to evaluate our colonoscopy success and results. Material and Methods: This retrospective descriptive study was performed in İstanbul Eren hospital endoscopy unit between 2012 and 2015. Colonoscopy results and patient demographics were obtained from the hospital database...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29756019/size-of-colorectal-polyps-determines-time-taken-to-remove-them-endoscopically
#14
Heechan Kang, Mo Hameed Thoufeeq
Background an study aims:  Polypectomy and endoscopic mucosal resection (EMR) are effective and safe ways of removing polyps from the colon at endoscopy. Guidelines exist for advising the time allocation for diagnostic endoscopy but not for polypectomy and EMR. The aim of this study was to identify if time allocated for polypectomy and EMR at planned therapeutic lists in our endoscopy unit is sufficient for procedures to be carried out. We also wanted to identify factors that might be associated with procedures taking longer than the allocated time and to identify factors that might predict duration of these procedures...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29747061/serrated-epithelial-colorectal-polyps-hyperplastic-polyps-sessile-serrated-adenomas-with-perineurial-stroma-clinicopathological-and-molecular-analysis-of-a-new-series
#15
Katharina Erlenbach-Wünsch, Michel Bihl, Arndt Hartmann, Gabriel M Groisman, Michael Vieth, Abbas Agaimy
Serrated colorectal fibroblastic polyps (FPs) are rare benign mucosal lesions composed of serrated epithelial crypts separated and distorted by intimately associated bland spindle cell proliferations with perineurial-like phenotype. We herein describe 21 new FPs affecting 10 females and 9 males aged 45 to 80 yrs. (mean, 62 yrs). Lesions originated in the sigmoid colon/rectosigmoid junction (n = 16), rectum (n = 2), and other parts of the colon (n = 3). Most patients had additional synchronous or metachronous polyps: classical adenomas (12 patients), sessile serrated adenoma/SSA (1 patient), hyperplastic polyps/HPs (7 patients), both HPs and adenomas (6 patients) and colorectal cancer (2 patients)...
May 4, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29740804/colorectal-cancer-screening-preferences-past-behavior-and-future-intentions
#16
Carol Mansfield, Donatus U Ekwueme, Florence K L Tangka, Derek S Brown, Judith Lee Smith, Gery P Guy, Chunyu Li, Brett Hauber
BACKGROUND: Screening rates for colorectal cancer are below the Healthy People 2020 goal. There are several colorectal cancer screening tests that differ in terms of accuracy, recommended frequency, and administration. In this article, we compare how a set of personal characteristics correlates with preferences for colorectal cancer screening test attributes, past colorectal cancer screening behavior, and future colorectal cancer screening intentions. METHODS: We conducted a discrete-choice experiment survey to assess relative preferences for attributes of colorectal cancer screening tests among adults aged 50-75 years in USA...
May 9, 2018: Patient
https://www.readbyqxmd.com/read/29739023/the-clinical-significance-and-synchronous-polyp-burden-of-large-%C3%A2-20-mm-sessile-serrated-polyps-in-patients-without-serrated-polyposis-syndrome
#17
Lobke Desomer, David J Tate, Mahesh Jayanna, Maria Pellise, Halim Awadie, Nicholas G Burgess, Duncan McLeod, Hema Mahajan, Eric Y T Lee, Stephen J Williams, Michael J Bourke
BACKGROUND:  Sessile serrated polyps (SSPs) are important precursors of colorectal carcinoma and interval cancer. Large SSPs (≥ 20 mm) outside the definition of serrated polyposis syndrome (SPS) have not been studied in comparison with SPS. We aimed to describe the characteristics of patients with large SSPs in this context. METHODS:  Patients with at least one SSP (≥ 20 mm) were eligible. Data from three consecutive colonoscopies were used to compare clinical and endoscopic characteristics in three patient groups: SPS, a solitary large SSP, and patients with at least two SSPs without fulfilling the criteria for SPS (oligo-SSP)...
May 8, 2018: Endoscopy
https://www.readbyqxmd.com/read/29738362/colonic-adenomatous-polyps-involving-submucosal-lymphoglandular-complexes-a-diagnostic-pitfall
#18
Hee Eun Lee, Tsung-Teh Wu, Vishal S Chandan, Michael S Torbenson, Taofic Mounajjed
Lymphoglandular complexes (LGCs) are lymphoid nodules containing intestinal mucosa, present in close apposition to muscularis mucosae or submucosa. Rarely, colorectal adenomas involve submucosal LGCs, simulating invasive adenocarcinoma with associated submucosal lymphoid aggregates, and presenting a diagnostic pitfall. We aimed to identify distinctive histologic features between submucosal LGCs and true invasion. Seven adenomas (tubular/tubulovillous adenomas [n=6], including 4 with high-grade dysplasia and 1 with focal intramucosal adenocarcinoma, and sessile serrated adenoma [n=1]) were in the right (n=5) and left colon (n=2)...
May 4, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29736317/klf5-mediates-the-hyper-proliferative-phenotype-of-the-intestinal-epithelium-in-mice-with-intestine-specific-endogenous-k-ras-g12d-expression
#19
Mandayam O Nandan, Agnieszka B Bialkowska, Vincent W Yang
Oncogenic K-Ras activation is a common mutational event in colorectal cancer. We previously showed that transcription factor, Krüppel-like factor 5 (KLF5), contributes to intestinal polyposis in mice with K-Ras activation. At 14 months of age, Villin-Cre/LSL-K-RasG12D mice developed small intestinal and colonic hyperplastic polyps while LSL-K-RasG12D had none. The intestinal crypts of Villin-Cre/LSL-K-RasG12D mice contained a higher number of mitotic figures and increased crypt heights compared to controls...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29730903/analysis-of-syndecan-2-methylation-in-bowel-lavage-fluid-for-detection-of-colorectal-neoplasm
#20
Young Sook Park, Dong Shin Kim, Sang Woo Cho, Jong Won Park, Sang Jin Jeon, Tae Ju Moon, Seong Hwan Kim, Byoung Kwan Son, TaeJeong Oh, Sungwhan An, Jeong HwanKim, Jeong Don Chae
Background/Aims: Syndecan-2 ( SDC2 ) methylation was previously reported as a sensitive serologic biomarker for the early detection of colorectal cancer (CRC). The purpose of this study was to investigate whether SDC2 methylation is detectable in precancerous lesions and to determine the feasibility of using SDC2 methylation for the detection of CRC and precancerous lesions in bowel lavage fluid (BLF). Methods: A total of 190 BLF samples were collected from the rectum at the beginning of colonoscopy from patients with colorectal neoplasm and healthy normal individuals...
May 4, 2018: Gut and Liver
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