keyword
MENU ▼
Read by QxMD icon Read
search

Colorectal dysplasia

keyword
https://www.readbyqxmd.com/read/28729694/paracrine-cyclooxygenase-2-activity-by-macrophages-drives-colorectal-adenoma-progression-in-the-apc-min-mouse-model-of-intestinal-tumorigenesis
#1
Mark A Hull, Richard J Cuthbert, C W Stanley Ko, Daniel J Scott, Elizabeth J Cartwright, Gillian Hawcroft, Sarah L Perry, Nicola Ingram, Ian M Carr, Alexander F Markham, Constanze Bonifer, P Louise Coletta
Genetic deletion or pharmacological inhibition of cyclooxygenase (COX)-2 abrogates intestinal adenoma development at early stages of colorectal carcinogenesis. COX-2 is localised to stromal cells (predominantly macrophages) in human and mouse intestinal adenomas. Therefore, we tested the hypothesis that paracrine Cox-2-mediated signalling from macrophages drives adenoma growth and progression in vivo in the Apc (Min/+) mouse model of intestinal tumorigenesis. Using a transgenic C57Bl/6 mouse model of Cox-2 over-expression driven by the chicken lysozyme locus (cLys-Cox-2), which directs integration site-independent, copy number-dependent transgene expression restricted to macrophages, we demonstrated that stromal macrophage Cox-2 in colorectal (but not small intestinal) adenomas from cLys-Cox-2 x Apc (Min/+) mice was associated with significantly increased tumour size (P = 0...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28704539/streptococcus-gallolyticus-subsp-gallolyticus-promotes-colorectal-tumor-development
#2
Ritesh Kumar, Jennifer L Herold, Deborah Schady, Jennifer Davis, Scott Kopetz, Margarita Martinez-Moczygemba, Barbara E Murray, Fang Han, Yu Li, Evelyn Callaway, Robert S Chapkin, Wan-Mohaiza Dashwood, Roderick H Dashwood, Tia Berry, Chris Mackenzie, Yi Xu
Streptococcus gallolyticus subsp. gallolyticus (Sg) has long been known to have a strong association with colorectal cancer (CRC). This knowledge has important clinical implications, and yet little is known about the role of Sg in the development of CRC. Here we demonstrate that Sg promotes human colon cancer cell proliferation in a manner that depends on cell context, bacterial growth phase and direct contact between bacteria and colon cancer cells. In addition, we observed increased level of β-catenin, c-Myc and PCNA in colon cancer cells following incubation with Sg...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28702134/evaluating-the-frequency-of-mlh-1-loss-in-serrated-polyps-of-colon-a-single-center-study-from-southern-iran
#3
Bita Geramizadeh, Nooshin Dindar, Samirasadat Hasheminasab, Tahere Haeidari
AIM: Evaluation of the role of MLH-1 loss in serrated polyps of colon in a population of South of Iran. BACKGROUND: There has been extensive change in classification and pathogenesis of serrated polyps of the colon during the last 10 years. The new classification is mostly based on the knowledge of the molecular pathogenesis and the rate of progression to colorectal cancer in these types of polyps. One of the most common and early lesions in molecular pathogenesis of serrated colorectal cancer is loss of MLH-1...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28698863/evaluation-of-the-expression-of-the-inhibitor-of-apoptosis-protein-family-and-human-telomerase-reverse-transcriptase-in-patients-with-advanced-colorectal-adenoma
#4
Joon Young Choi, Hyuk Yoon, Gyeongjae Na, Yoon Jin Choi, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
BACKGROUND: It has been reported that the expression of the inhibitor of apoptosis protein (IAP) family increases in patients with colon cancer. We evaluated the expression of the IAP family and human telomerase reverse transcriptase (hTERT) in normal colon mucosa from patients with advanced colorectal adenoma and investigated their features according to characteristics of advanced colorectal adenoma. METHODS: While resections of polyps were performed in patients (n = 80) diagnosed with advanced colorectal adenoma or carcinoma in situ, additional normal tissues were obtained from the sigmoid colon...
June 2017: Journal of Cancer Prevention
https://www.readbyqxmd.com/read/28694132/inflammatory-bowel-disease-and-small-bowel-cancer-risk-clinical-characteristics-and-histopathology-a-population-based-study
#5
Rasmus Dahlin Bojesen, Lene Buhl Riis, Estrid Høgdall, Ole Haagen Nielsen, Tine Jess
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) may increase risk of small bowel cancer (SBC). However, little is known of the characteristics and features of IBD-SBC, due to a low number of cases worldwide. We performed a population-based study of IBD and SBC to calculate risk and increase our understanding of clinical characteristics and histopathological and molecular features. METHODS: The study population consisted of all individuals 16 years or older living in Denmark during 1978-2010...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28693143/altered-expression-of-cytokeratin-7-and-cd117-in-transitional-mucosa-adjacent-to-human-colorectal-cancer
#6
Hideaki Kigasawa, Masachika Fujiwara, Jun Ishii, Tomohiro Chiba, Yuichi Terado, Hiroaki Shimoyamada, Makoto Mochizuki, Osamu Kitamura, Hiroshi Kamma, Yasuo Ohkura
The multi-step progression of colorectal cancer through precancerous lesions (adenoma and dysplasia) is associated with cumulative molecular alterations, a number of which have also been demonstrated to be present in morphologically normal transitional mucosa adjacent to colorectal cancer. The cytoskeletal protein cytokeratin 7 (CK7) and the receptor tyrosine kinase, KIT proto-oncogene receptor tyrosine kinase (CD117), encoded by the proto-oncogene c-Kit, are lacking in normal colorectal crypt epithelium and are aberrantly expressed in a subset of colorectal cancer...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690768/endoscopic-recommendations-for-colorectal-cancer-screening-and-surveillance-in-patients-with-inflammatory-bowel-disease-review-of-general-recommendations
#7
REVIEW
Jose María Huguet, Patricia Suárez, Luis Ferrer-Barceló, Lucía Ruiz, Ana Monzó, Ana Belén Durá, Javier Sempere
Screening for colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) is recommended by all scientific societies. However, there are differences in the recommendations they make regarding screening and surveillance. We address a series of questions that come up in the daily clinical practice of a physician. The first two questions that are raised are: (1) Who should be offered screening for CRC? and (2) When should the first colonoscopy be performed? The next step is to decide who should undergo endoscopic surveillance and at what intervals they should be performed...
June 16, 2017: World Journal of Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28690452/advances-in-the-diagnosis-and-management-of-colonic-dysplasia-in-patients-with-inflammatory-bowel-disease
#8
Shirley Cohen-Mekelburg, Yecheskel Schneider, Stephanie Gold, Ellen Scherl, Adam Steinlauf
The prevalence of colorectal cancer (CRC) in inflammatory bowel disease (IBD) is estimated at 3.7%. Risk factors for CRC include more severe disease (as reflected by the extent of disease and the duration of poorly controlled disease), family history of CRC, pseudopolyps, primary sclerosing cholangitis, and male sex. In addition, both early and late onset of IBD have been shown to be risk factors in different studies. Most societal guidelines recommend initiation of surveillance colonoscopy at 8 to 10 years after IBD symptom onset, followed by subsequent surveillance in 1- to 2-year intervals...
June 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28690450/the-role-of-chromoendoscopy-in-evaluating-colorectal-dysplasia
#9
Anna M Buchner
Chromoendoscopy pertains to image-enhanced endoscopic techniques such as dye-based chromoendoscopy and electronic chromoendoscopy using narrow-band imaging, flexible spectral imaging color enhancement, and i-scan. Dye-based chromoendoscopy has been demonstrated to improve colorectal dysplasia detection in high-risk patients with long-term inflammatory bowel disease, and electronic chromoendoscopy techniques have been shown to improve characterization of diminutive colorectal lesions, allowing for optical diagnosis during a colonoscopy examination...
June 2017: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28686677/mdr1a-deficiency-restrains-tumor-growth-in-murine-colitis-associated-carcinogenesis
#10
Eva Maria Hennenberg, Annette Eyking, Henning Reis, Elke Cario
Patients with Ulcerative Colitis (UC) have an increased risk to develop colitis-associated colorectal cancer (CAC). Here, we found that protein expression of ABCB1 (ATP Binding Cassette Subfamily B Member 1) / MDR1 (multidrug resistance 1) was diminished in the intestinal mucosa of patients with active UC with or without CAC, but not in non-UC patients with sporadic colon cancer. We investigated the consequences of ABCB1/MDR1 loss-of-function in a common murine model for CAC (AOM/DSS). Mice deficient in MDR1A (MDR1A KO) showed enhanced intratumoral inflammation and cellular damage, which were associated with reduced colonic tumor size and decreased degree of dysplasia, when compared to wild-type (WT)...
2017: PloS One
https://www.readbyqxmd.com/read/28682975/surgery-for-colorectal-cancer-in-crohn-s-disease-should-we-perform-a-total-proctocolectomy-for-all-patients-with-high-grade-dysplasia-and-cancer-in-crohn-s-disease
#11
https://www.readbyqxmd.com/read/28655982/clinical-impact-of-the-immunochemical-fecal-occult-blood-test-for-colorectal-cancer-screening-in-brazil
#12
Cláudio R Teixeira, Michele L Bonotto, Júlio P Lima, Luciana F Figueiredo, Leonardo Conrado, Carlos Frasca
BACKGROUND: Colorectal cancer (CRC) screening programs based on the fecal occult blood test (FOBT) reduce CRC mortality. We carried out an observational prospective study to determine the accuracy of immunochemical FOBTs for the detection of CRC in individuals at average risk for the disease. METHODS: This population-based study was performed between April 2015 and January 2016 in two gastroenterology referral centers in Southern Brazil. It included 1039 average-risk volunteers aged 50-75 years who were symptom-free for colonic disease...
2017: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/28631086/nearly-a-third-of-high-grade-dysplasia-and-colorectal-cancer-is-undetected-in-patients-with-inflammatory-bowel-disease
#13
Swathi Eluri, Alyssa M Parian, Berkeley N Limketkai, Christina Y Ha, Steven R Brant, Sharon Dudley-Brown, Jonathan E Efron, Sandy G Fang, Susan L Gearhart, Michael R Marohn, Stephen J Meltzer, Safar Bashar, Brindusa Truta, Elizabeth A Montgomery, Mark G Lazarev
BACKGROUND: It is unclear whether intensive surveillance protocols have resulted in a decreased incidence of colorectal cancer (CRC) in inflammatory bowel disease (IBD). AIMS: To determine the prevalence and characteristics of IBD associated high-grade dysplasia (HGD) or CRC that was undetected on prior colonoscopy. METHODS: This is a single-center, retrospective study from 1994 to 2013. All participants had a confirmed IBD diagnosis and underwent a colectomy with either HGD or CRC found in the colectomy specimen...
June 19, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28614199/wnt-pathway-gene-mutations-are-associated-with-the-presence-of-dysplasia-in-colorectal-sessile-serrated-adenoma-polyps
#14
Taiki Hashimoto, Satoshi Yamashita, Hiroshi Yoshida, Hirokazu Taniguchi, Toshikazu Ushijima, Tesshi Yamada, Yutaka Saito, Atsushi Ochiai, Shigeki Sekine, Nobuyoshi Hiraoka
Sessile serrated adenoma/polyps (SSA/Ps) are believed to be the major precursor of serrated pathway-derived colorectal carcinomas. To better characterize the process of progression from SSA/Ps to carcinomas, we analyzed 46 SSA/Ps with dysplasia and 45 SSA/Ps without dysplasia using targeted next-generation sequencing and immunohistochemistry. Among the WNT pathway genes analyzed, protein-truncating mutations of RNF43, APC, and ZNRF3 were identified in 23 (50%), 4 (9%), and 3 (7%) SSA/Ps with dysplasia, respectively...
June 13, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28611980/there-is-no-role-for-colonoscopy-after-diverticulitis-among-asian-patients-less-than-50-years-of-age
#15
Dedrick Kok Hong Chan, Ker-Kan Tan
BACKGROUND: Colonoscopy is advocated following acute diverticulitis to ensure that malignancy is not missed. In an Asian population, diverticulitis is more common in the right colon and in younger patients. The purpose of this study is to examine the utility of colonoscopy amongst Asian patients <50 years of age who have had colonic diverticulitis. METHODS: A retrospective review of all patients aged 50 years and under who were treated for colonic diverticulitis between 2012 and 2014 was performed...
March 2017: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/28586045/low-htra1-expression-in-patients-with-long%C3%A2-standing-ulcerative-colitis-and-colorectal-cancer
#16
Emma Altobelli, Giovanni Latella, Manrico Morroni, Caterina Licini, Giovanni Tossetta, Roberta Mazzucchelli, Valerio F Profeta, Gino Coletti, Pietro Leocata, Mario Castellucci, Mario Guerrieri, Reimondo Petrocelli, Berardo De Berardis, Marina De Padova, Gabriella Di Leonardo, Antonella Paladini, Filippo Mignosi, Gina Quaglione, Roberto Fagnano, Daniela Marzioni
The association between inflammatory bowel disease (IBD) and colorectal cancer (CRC) is being increasingly investigated. HtrA1 overexpression inhibits cell growth and proliferation by influencing apoptosis, invasiveness and migration of tumour cells. In the present study, HtrA1 expression was analysed in 228 colon tissue samples from patients with CRC, adenoma with high-grade dysplasia (AHD), adenoma with low-grade dysplasia (ALD), ulcerative colitis of >10 year duration (UCL), ulcerative colitis of <5 year duration (UCS) and colonic diverticulitis (D), and was compared with its expression in normal colon tissues (NCTs) collected 5 cm from the CRC lesion and in healthy colon mucosa (HC), to establish whether HtrA1 can serve as a biomarker for these conditions...
June 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28566588/limited-identification-of-dual-time-point-positron-emission-tomography-computed-tomography-in-advanced-colorectal-neoplasms
#17
Kazuhiro Kashiwagi, Yoshihiro Nakazato, Mari Arai, Eisuke Iwasaki, Makoto Naganuma, Nagamu Inoue, Yasushi Iwao, Haruhiko Ogata, Koji Murakami, Takanori Kanai
Objective We investigated whether dual-time-point 18-Fluorodeoxyglucose ((18)FDG) positron emission tomography/computed tomography (PET/CT) could improve the positive predictive value for detecting advanced colorectal neoplasms (cancer, adenoma ≥10 mm or adenoma with high-grade dysplasia). Methods We retrospectively searched for consecutive patients with a known primary cancer, who had a colonic (18)FDG uptake incidentally found by PET/CT, followed by colonoscopy between January 2013 and August 2014. The clinical characteristics including the maximum standardized uptake value (SUVmax) were compared between advanced colorectal neoplasms and non-advanced lesions...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28560510/the-role-of-neurotensin-as-a-novel-biomarker-in-the-endoscopic-screening-of-high-risk-population-for-developing-colorectal-neoplasia
#18
Christos Kontovounisios, Shengyang Qiu, Shahnawaz Rasheed, Ara Darzi, Paris Tekkis
Colorectal cancer screening programs aim at early detection of cancer to reduce incidence rates and mortality. The objective of this study is to identify the role of neurotensin in the endoscopic screening of high-risk population for developing colorectal neoplasia. Blood samples from patients referred for urgent colonoscopy to investigate symptoms suspicious of colorectal cancer were collected. Blood neurotensin levels were measured using enzyme-linked immunosorbent assay. Colonoscopy findings were used as reference for determining the diagnostic accuracy of blood neurotensin...
May 30, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28554134/lactobacillus-rhamnosus-atcc-7469-exopolysaccharides-synergizes-with-low-level-ionizing-radiation-to-modulate-signaling-molecular-targets-in-colorectal-carcinogenesis-in-rats
#19
Walid E Zahran, Sawsan M Elsonbaty, Fatma S M Moawed
Combination therapy that targets cellular signaling pathway represents an alternative therapy for the treatment of colon cancer (CRC). The present study was therefore aimed to investigate the probable interaction of Lactobacillus rhamnosus ATCC 7469 exopolysaccharides (EPS) with low level ionizing γ radiation (γ-R) exposure against dimethylhydrazine (DMH)- induced colorectal carcinogenesis in rats. Colon cancer was induced with 20mg DMH/kg BW. Rats received daily by gastric gavage 100mg EPS/Kg BW concomitant with 1Gy γ-R over two months...
August 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28524162/targeted-sequencing-based-analyses-of-candidate-gene-variants-in-ulcerative-colitis-associated-colorectal-neoplasia
#20
Sanjiban Chakrabarty, Vinay Koshy Varghese, Pranoy Sahu, Pradyumna Jayaram, Bhadravathi M Shivakumar, Cannanore Ganesh Pai, Kapaettu Satyamoorthy
BACKGROUND: Long-standing ulcerative colitis (UC) leading to colorectal cancer (CRC) is one of the most serious and life-threatening consequences acknowledged globally. Ulcerative colitis-associated colorectal carcinogenesis showed distinct molecular alterations when compared with sporadic colorectal carcinoma. METHODS: Targeted sequencing of 409 genes in tissue samples of 18 long-standing UC subjects at high risk of colorectal carcinoma (UCHR) was performed to identify somatic driver mutations, which may be involved in the molecular changes during the transformation of non-dysplastic mucosa to high-grade dysplasia...
June 27, 2017: British Journal of Cancer
keyword
keyword
24135
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"