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Hyperacusis

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https://www.readbyqxmd.com/read/29773471/increased-spontaneous-firing-rates-in-auditory-midbrain-following-noise-exposure-are-specifically-abolished-by-a-kv3-channel-modulator
#1
Lucy A Anderson, Lara L Hesse, Nadia Pilati, Warren M H Bakay, Giuseppe Alvaro, Charles H Large, David McAlpine, Roland Schaette, Jennifer F Linden
Noise exposure has been shown to produce long-lasting increases in spontaneous activity in central auditory structures in animal models, and similar pathologies are thought to contribute to clinical phenomena such as hyperacusis or tinnitus in humans. Here we demonstrate that multi-unit spontaneous neuronal activity in the inferior colliculus (IC) of mice is significantly elevated four weeks following noise exposure at recording sites with frequency tuning within or near the noise exposure band, and this selective central auditory pathology can be normalised through administration of a novel compound that modulates activity of Kv3 voltage-gated ion channels...
April 30, 2018: Hearing Research
https://www.readbyqxmd.com/read/29742543/psychometric-properties-and-factor-structure-of-a-new-scale-to-measure-hyperacusis-introducing-the-inventory-of-hyperacusis-symptoms
#2
Benjamin Greenberg, Megan Carlos
OBJECTIVES: Despite increasing interest in hyperacusis and other disorders of auditory sensitivity, there is still a lack of valid, standardized assessment tools to measure symptom severity, treatment outcomes, and diagnostic differentiation. Accordingly, this study sought to create a new scale that is reliable, valid, brief, and easy to score with the purpose of filling this gap. DESIGN: Original items were constructed through review of currently existing models of hyperacusis measurement, as well as qualitative data collected from professional audiologists and individuals reporting heightened audiological sensitivity with tinnitus...
May 8, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29688102/uncomfortable-loudness-levels-among-children-and-adolescents-seeking-help-for-tinnitus-and-or-hyperacusis
#3
Hashir Aazh, Don McFerran, Brian C J Moore
OBJECTIVE: To assess the prevalence of hyperacusis and severe hyperacusis among children and adolescents seen at an audiology outpatient tinnitus and hyperacusis service. DESIGN: This was a retrospective study. Hyperacusis was considered as present if the average uncomfortable loudness level (ULL) at 0.25, 0.5, 1, 2, 4 and 8 kHz for the ear with the lower average ULL, which is denoted as ULLmin, was ≤77 dB HL. Severe hyperacusis was considered as present if the ULL was 30 dB HL or less for at least one of the measured frequencies for at least one ear...
April 24, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29649793/long-term-effects-of-middle-ear-tendon-resection-on-middle-ear-myoclonic-tinnitus-hearing-and-hyperacusis
#4
Dong-Kee Kim, Jung Mee Park, Jung Ju Han, Yun Min Chung, Jung Min Kim, So Young Park, Shi Nae Park
OBJECTIVE: To evaluate the therapeutic effects of middle ear tendon resection (METR) on middle ear myoclonic tinnitus (MEMT) and to investigate its long-term effects on hearing and hyperacusis. MATERIALS AND METHODS: Thirty-seven patients with MEMT with a mean age of 33.2 ± 11.8 years were included in this study. METR was performed on all 37 MEMT patients (41 ears) between November 2004 and August 2016. The mean follow-up period was 16.1 months. We examined changes in tinnitus and accompanying stress and depression in patients after surgery, and examined the hearing changes and the occurrence of complications including hyperacusis...
April 12, 2018: Audiology & Neuro-otology
https://www.readbyqxmd.com/read/29625214/blast-exposure-disrupts-tonotopic-frequency-map-in-the-primary-auditory-cortex
#5
Samer Masri, Li S Zhang, Hao Luo, Edward Pace, Jinsheng Zhang, Shaowen Bao
Blast exposure can cause various auditory disorders including tinnitus, hyperacusis, and other central auditory processing disorders. While this is suggestive of patholologies in the central auditory system, the impact of blast exposure on central auditory processing remains poorly understood. Here we examined the effects of blast shockwaves on acoustic response properties and frequency mapping in auditory cortex. We found that multiunits recording from the auditory cortex exhibited higher acoustic thresholds and broader frequency tuning in blast-exposed animals...
April 3, 2018: Neuroscience
https://www.readbyqxmd.com/read/29593786/acoustic-trauma-changes-the-parvalbumin-positive-neurons-in-rat-auditory-cortex
#6
Congli Liu, Tao Xu, Xiaopeng Liu, Yina Huang, Haitao Wang, Bin Luo, Jingwu Sun
Acoustic trauma is being reported to damage the auditory periphery and central system, and the compromised cortical inhibition is involved in auditory disorders, such as hyperacusis and tinnitus. Parvalbumin-containing neurons (PV neurons), a subset of GABAergic neurons, greatly shape and synchronize neural network activities. However, the change of PV neurons following acoustic trauma remains to be elucidated. The present study investigated how auditory cortical PV neurons change following unilateral 1 hour noise exposure (left ear, one octave band noise centered at 16 kHz, 116 dB SPL)...
2018: Neural Plasticity
https://www.readbyqxmd.com/read/29576731/aggressiveness-violence-homicidality-homicide-and-lyme-disease
#7
Robert C Bransfield
Background: No study has previously analyzed aggressiveness, homicide, and Lyme disease (LD). Materials and methods: Retrospective LD chart reviews analyzed aggressiveness, compared 50 homicidal with 50 non-homicidal patients, and analyzed homicides. Results: Most aggression with LD was impulsive, sometimes provoked by intrusive symptoms, sensory stimulation or frustration and was invariably bizarre and senseless. About 9.6% of LD patients were homicidal with the average diagnosis delay of 9 years...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29532738/prolonged-exposure-of-cba-ca-mice-to-moderately-loud-noise-can-cause-cochlear-synaptopathy-but-not-tinnitus-or-hyperacusis-as-assessed-with-the-acoustic-startle-reflex
#8
Martin Pienkowski
Hearing loss changes the auditory brain, sometimes maladaptively. When deprived of cochlear input, central auditory neurons become more active spontaneously and begin to respond more strongly and synchronously to better preserved sound frequencies. This spontaneous and sound-evoked central hyperactivity has been postulated to trigger tinnitus and hyperacusis, respectively. Localized hyperactivity has also been observed after long-term exposure to noise levels that do not damage the cochlea. Adult animals exposed to bands of nondamaging noise exhibited suppressed spontaneous and sound-evoked activity in the area of primary auditory cortex (A1) stimulated by the exposure band but had increased spontaneous and evoked activity in neighboring A1 areas...
January 2018: Trends in Hearing
https://www.readbyqxmd.com/read/29501317/hyperacusis-in-children-a-clinical-profile
#9
Shibani Myne, Veronica Kennedy
OBJECTIVE: Hyperacusis is commonly seen in clinical paediatric practice and can be distressing for the children and their families. This paper looks at the clinical profile of children seen for hyperacusis in a paediatric audiology service and reviews the possible underlying mechanisms. METHODS: Retrospective study of case notes of 61 children with troublesome hyperacusis seen in the paediatric audiology service, looking at their clinical presentation and presence of other medical conditions...
April 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29488875/thoughts-about-suicide-and-self-harm-in-patients-with-tinnitus-and-hyperacusis
#10
Hashir Aazh, Brian C J Moore
BACKGROUND: There are conflicting reports with regard to the relationship between suicidal ideations and tinnitus and hyperacusis. Audiology departments play a major role in offering therapy and support for patients experiencing tinnitus and hyperacusis. If suicidal and self-harm ideations among patients seen in audiology clinics are high, then it would be important to screen for them to make onward referrals to mental health services. PURPOSE: The aim of this study was to assess the prevalence of and factors related to suicidal and self-harm ideations in patients with tinnitus and hyperacusis seen at an audiology outpatient service...
March 2018: Journal of the American Academy of Audiology
https://www.readbyqxmd.com/read/29488007/tinnitus-and-temporary-hearing-loss-result-in-differential-noise-induced-spatial-reorganization-of-brain-activity
#11
Antonela Muca, Emily Standafer, Aaron K Apawu, Farhan Ahmad, Farhad Ghoddoussi, Mirabela Hali, James Warila, Bruce A Berkowitz, Avril Genene Holt
Loud noise frequently results in hyperacusis or hearing loss (i.e., increased or decreased sensitivity to sound). These conditions are often accompanied by tinnitus (ringing in the ears) and changes in spontaneous neuronal activity (SNA). The ability to differentiate the contributions of hyperacusis and hearing loss to neural correlates of tinnitus has yet to be achieved. Towards this purpose, we used a combination of behavior, electrophysiology, and imaging tools to investigate two models of noise-induced tinnitus (either with temporary hearing loss or with permanent hearing loss)...
February 27, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29452318/bone-metabolic-markers-in-the-clinical-assessment-of-patients-with-superior-semicircular-canal-dehiscence
#12
Thien Nguyen, Carlito Lagman, John P Sheppard, Courtney Duong, Vera Ong, Jessica Poon, Yasmine Alkhalid, Daniel Azzam, Prasanth Romiyo, Giyarpuram N Prashant, Quinton Gopen, Isaac Yang
BACKGROUND: Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We investigated the relationship between bone metabolic markers and symptoms in patients with SSCD. METHODS: We collected patient demographics and clinical parameters for adult patients diagnosed with SSCD on high-resolution computed tomography scans...
February 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29415588/proportion-and-characteristics-of-patients-who-were-offered-enrolled-in-and-completed-audiologist-delivered-cognitive-behavioural-therapy-for-tinnitus-and-hyperacusis-rehabilitation-in-a-specialist-uk-clinic
#13
Hashir Aazh, Brian C J Moore
OBJECTIVE: The aim was to determine the proportion and characteristics of patients who were offered, enrolled in and completed an audiologist-delivered cognitive behavioural therapy (CBT) programme for tinnitus and/or hyperacusis in a specialist Audiology Department in the National Health Service, UK. DESIGN: This was a retrospective study. STUDY SAMPLE: Data were gathered for 266 consecutive patients with an average age of 56 y (standard deviation =15 y)...
February 7, 2018: International Journal of Audiology
https://www.readbyqxmd.com/read/29392341/hyperacusis-major-research-questions
#14
REVIEW
D M Baguley, D J Hoare
BACKGROUND: Hyperacusis is a troublesome symptom that can have a marked negative impact on quality of life. OBJECTIVES: To identify major research questions in hyperacusis. MATERIALS AND METHODS: Review of gaps in knowledge regarding hyperacusis, and where opportunities may lie to address these. RESULTS: Eight major research questions were identified as priorities for future research. These were: What is the prevalence of hyperacusis in adults and children? What are the risk factors associated with hyperacusis? What is the natural history of hyperacusis? How is 'pain hyperacusis' perceived? What mechanisms are involved in hyperacusis? What is the relationship between hyperacusis and tinnitus? Can a questionnaire be developed that accurately measures the impact of hyperacusis and can be used as a treatment outcome measure? What treatments, alone or in combination, are effective for hyperacusis? CONCLUSION: This clinical/researcher-led project identified major research questions in hyperacusis...
February 1, 2018: HNO
https://www.readbyqxmd.com/read/29370266/increased-parietal-circuit-breaker-activity-in-delta-frequency-band-and-abnormal-delta-theta-band-connectivity-in-salience-network-in-hyperacusis-subjects
#15
Jae Joon Han, Ji Hye Jang, Dirk De Ridder, Sven Vanneste, Ja-Won Koo, Jae-Jin Song
Recent studies have suggested that hyperacusis, an abnormal hypersensitivity to ordinary environmental sounds, may be characterized by certain resting-state cortical oscillatory patterns, even with no sound stimulus. However, previous studies are limited in that most studied subjects with other comorbidities that may have affected cortical activity. In this regard, to assess ongoing cortical oscillatory activity in idiopathic hyperacusis patients with no comorbidities, we compared differences in resting-state cortical oscillatory patterns between five idiopathic hyperacusis subjects and five normal controls...
2018: PloS One
https://www.readbyqxmd.com/read/29329983/attenuation-of-noise-induced-hyperactivity-in-the-dorsal-cochlear-nucleus-by-pre-treatment-with-mk-801
#16
M W Criddle, D A Godfrey, J A Kaltenbach
It has previously been hypothesized that hyperactivity of central auditory neurons following exposure to intense noise is a consequence of synaptic alterations. Recent studies suggest the involvement of NMDA receptors in the induction of this hyperactive state. NMDA receptors can mediate long term changes in the excitability of neurons through their involvement in excitotoxic injury and long term potentiation and depression. In this study, we examined the effect of administering an NMDA receptor blocker on the induction of hyperactivity in the dorsal cochlear nucleus (DCN) following intense sound exposure...
March 1, 2018: Brain Research
https://www.readbyqxmd.com/read/29234817/neural-plasticity-and-its-initiating-conditions-in-tinnitus
#17
REVIEW
L E Roberts
BACKGROUND AND OBJECTIVE: Deafferentation caused by cochlear pathology (which can be hidden from the audiogram) activates forms of neural plasticity in auditory pathways, generating tinnitus and its associated conditions including hyperacusis. This article discusses tinnitus mechanisms and suggests how these mechanisms may relate to those involved in normal auditory information processing. MATERIALS AND METHODS: Research findings from animal models of tinnitus and from electromagnetic imaging of tinnitus patients are reviewed which pertain to the role of deafferentation and neural plasticity in tinnitus and hyperacusis...
March 2018: HNO
https://www.readbyqxmd.com/read/29209701/factors-associated-with-depression-in-patients-with-tinnitus-and-hyperacusis
#18
Hashir Aazh, Brian C J Moore
Purpose: The purpose of this study was to assess factors associated with depression for patients with tinnitus and hyperacusis. Method: Data were gathered from the records of 620 consecutive patients who sought help concerning their tinnitus or hyperacusis from an audiology clinic in the United Kingdom. Results: One third of the patients had borderline abnormal or abnormal scores on the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D)...
December 12, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29204664/-central-and-peripheral-aspects-of-noise-induced-hearing-loss
#19
REVIEW
D Basta, M Gröschel, A Ernst
Noise is an important socioeconomic problem in industrialized countries. Development of efficient treatment options for the audiological phenomena resulting from noise-induced hearing loss requires in-depth understanding of the underlying damage mechanisms causing peripheral and central nervous changes. Mechanical damage, ischemia and excitotoxicity are mainly responsible for noise-induced cell death and biophysical changes in the cochlea. Auditory synaptopathy is an additional consequence. Besides these cochlear pathologies, noise exposure leads to extensive changes within the central auditory pathway...
December 4, 2017: HNO
https://www.readbyqxmd.com/read/29192616/assessment-of-reduced-tolerance-to-sound-hyperacusis-in-university-students
#20
Sule Yilmaz, Memduha Taş, Erdoğan Bulut, Elçin Nurçin
INTRODUCTION: Hyperacusis is defined as a reduction in tolerance to ordinary environmental sounds. Hyperacusis can occur in individuals of all age groups, making daily life difficult for the sufferers. Although there is no objective test to accurately diagnose hyperacusis, questionnaires are useful for the assessment of hyperacusis. The aim of this study was to explore the reduced sound tolerance in university students using a hyperacusis questionnaire (HQ). MATERIALS AND METHODS: A total of 536 university students (300 females and 236 males) aged between 18 and 25 years, with a mean age of 21...
March 2017: Noise & Health
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