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Hyperacusis

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https://www.readbyqxmd.com/read/29329983/attenuation-of-noise-induced-hyperactivity-in-the-dorsal-cochlear-nucleus-by-pre-treatment-with-mk-801
#1
M W Criddle, D A Godfrey, J A Kaltenbach
It has previously been hypothesized that hyperactivity of central auditory neurons following exposure to intense noise is a consequence of synaptic alterations. Recent studies suggest the involvement of NMDA receptors in the induction of this hyperactive state. NMDA receptors can mediate long term changes in the excitability of neurons through their involvement in excitotoxic injury and long term potentiation and depression. In this study, we examined the effect of administering an NMDA receptor blocker on the induction of hyperactivity in the dorsal cochlear nucleus (DCN) following intense sound exposure...
January 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29234817/neural-plasticity-and-its-initiating-conditions-in-tinnitus
#2
REVIEW
L E Roberts
BACKGROUND AND OBJECTIVE: Deafferentation caused by cochlear pathology (which can be hidden from the audiogram) activates forms of neural plasticity in auditory pathways, generating tinnitus and its associated conditions including hyperacusis. This article discusses tinnitus mechanisms and suggests how these mechanisms may relate to those involved in normal auditory information processing. MATERIALS AND METHODS: Research findings from animal models of tinnitus and from electromagnetic imaging of tinnitus patients are reviewed which pertain to the role of deafferentation and neural plasticity in tinnitus and hyperacusis...
December 12, 2017: HNO
https://www.readbyqxmd.com/read/29209701/factors-associated-with-depression-in-patients-with-tinnitus-and-hyperacusis
#3
Hashir Aazh, Brian C J Moore
Purpose: The purpose of this study was to assess factors associated with depression for patients with tinnitus and hyperacusis. Method: Data were gathered from the records of 620 consecutive patients who sought help concerning their tinnitus or hyperacusis from an audiology clinic in the United Kingdom. Results: One third of the patients had borderline abnormal or abnormal scores on the Depression subscale of the Hospital Anxiety and Depression Scale (HADS-D)...
December 6, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/29204664/-central-and-peripheral-aspects-of-noise-induced-hearing-loss
#4
REVIEW
D Basta, M Gröschel, A Ernst
Noise is an important socioeconomic problem in industrialized countries. Development of efficient treatment options for the audiological phenomena resulting from noise-induced hearing loss requires in-depth understanding of the underlying damage mechanisms causing peripheral and central nervous changes. Mechanical damage, ischemia and excitotoxicity are mainly responsible for noise-induced cell death and biophysical changes in the cochlea. Auditory synaptopathy is an additional consequence. Besides these cochlear pathologies, noise exposure leads to extensive changes within the central auditory pathway...
December 4, 2017: HNO
https://www.readbyqxmd.com/read/29192616/assessment-of-reduced-tolerance-to-sound-hyperacusis-in-university-students
#5
Sule Yilmaz, Memduha Taş, Erdoğan Bulut, Elçin Nurçin
INTRODUCTION: Hyperacusis is defined as a reduction in tolerance to ordinary environmental sounds. Hyperacusis can occur in individuals of all age groups, making daily life difficult for the sufferers. Although there is no objective test to accurately diagnose hyperacusis, questionnaires are useful for the assessment of hyperacusis. The aim of this study was to explore the reduced sound tolerance in university students using a hyperacusis questionnaire (HQ). MATERIALS AND METHODS: A total of 536 university students (300 females and 236 males) aged between 18 and 25 years, with a mean age of 21...
March 2017: Noise & Health
https://www.readbyqxmd.com/read/29191772/gap-induced-reductions-of-evoked-potentials-in-the-auditory-cortex-a-possible-objective-marker-for-the-presence-of-tinnitus
#6
Joel I Berger, William Owen, Caroline A Wilson, Adam Hockley, Ben Coomber, Alan R Palmer, Mark N Wallace
Animal models of tinnitus are essential for determining the underlying mechanisms and testing pharmacotherapies. However, there is doubt over the validity of current behavioural methods for detecting tinnitus. Here, we applied a stimulus paradigm widely used in a behavioural test (gap-induced inhibition of the acoustic startle reflex GPIAS) while recording from the auditory cortex, and showed neural response changes that mirror those found in the behavioural tests. We implanted guinea pigs (GPs) with electrocorticographic (ECoG) arrays and recorded baseline auditory cortical responses to a startling stimulus...
November 27, 2017: Brain Research
https://www.readbyqxmd.com/read/29187555/complementary-metrics-of-human-auditory-nerve-function-derived-from-compound-action-potentials
#7
Kelly C Harris, Kenneth I Vaden, Carolyn M McClaskey, James W Dias, Judy R Dubno
Declines in auditory nerve (AN) function contribute to suprathreshold auditory processing and communication deficits in individuals with normal hearing, hearing loss, hyperacusis, and tinnitus. Procedures to characterize AN loss or dysfunction in humans are limited. We report several novel complementary metrics using the compound action potential (CAP), a direct measure of summated AN activity. Together, these metrics may be used to characterize AN function noninvasively in humans. We examined how these metrics change with stimulus intensity, and interpreted these changes within a framework of known physiological properties of the basilar membrane and AN...
November 29, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29161302/characteristics-of-somatic-tinnitus-patients-with-and-without-hyperacusis
#8
Massimo Ralli, Richard J Salvi, Antonio Greco, Rosaria Turchetta, Armando De Virgilio, Giancarlo Altissimi, Giuseppe Attanasio, Giancarlo Cianfrone, Marco de Vincentiis
OBJECTIVE: Determine if somatic tinnitus patients with hyperacusis have different characteristics from those without hyperacusis. PATIENTS AND METHODS: 172 somatic tinnitus patients with (n = 82) and without (n = 90) hyperacusis referred to the Tinnitus Unit of Sapienza University of Rome between June 2012 and June 2016 were compared for demographic characteristics, tinnitus features, self-administered questionnaire scores, nature of somatic modulation and history...
2017: PloS One
https://www.readbyqxmd.com/read/29114160/clinical-characteristics-of-troublesome-pediatric-tinnitus
#9
Annett Szibor, Topi Jutila, Antti Mäkitie, Antti Aarnisalo
Objectives: The frequency of tinnitus in children and adults is practically the same. However, although adults reveal their symptoms and seek for medical aid, the suffering often remains unrecognized in the young. This is due to both the inability of children to properly describe their symptoms and the lack of recognition. Materials and methods: Among 5768 patients entering our department with complaints of tinnitus between 2010 and 2015, there were only 112 children...
2017: Clinical Medicine Insights. Ear, Nose and Throat
https://www.readbyqxmd.com/read/29108871/effects-of-the-cannabinoid-cb1-agonist-acea-on-salicylate-ototoxicity-hyperacusis-and-tinnitus-in-guinea-pigs
#10
Joel I Berger, Ben Coomber, Samantha Hill, Steve P H Alexander, William Owen, Alan R Palmer, Mark N Wallace
Cannabinoids have been suggested as a therapeutic target for a variety of brain disorders. Despite the presence of their receptors throughout the auditory system, little is known about how cannabinoids affect auditory function. We sought to determine whether administration of arachidonyl-2'-chloroethylamide (ACEA), a highly-selective CB1 agonist, could attenuate a variety of auditory effects caused by prior administration of salicylate, and potentially treat tinnitus. We recorded cortical resting-state activity, auditory-evoked cortical activity and auditory brainstem responses (ABRs), from chronically-implanted awake guinea pigs, before and after salicylate + ACEA...
October 31, 2017: Hearing Research
https://www.readbyqxmd.com/read/29095725/audiologist-guided-internet-based-cognitive-behavior-therapy-for-adults-with-tinnitus-in-the-united-kingdom-a-randomized-controlled-trial
#11
Eldré W Beukes, David M Baguley, Peter M Allen, Vinaya Manchaiah, Gerhard Andersson
OBJECTIVES: Specialist tinnitus services are in high demand as a result of the negative effect tinnitus may have on quality of life. Additional clinically and cost-effective tinnitus management routes are needed. One potential route is providing Cognitive Behavioural Therapy for tinnitus via the Internet (iCBT). This study aimed to determine the efficacy of guided iCBT, using audiological support, on tinnitus distress and tinnitus-related comorbidities, in the United Kingdom. A further aim was to establish the stability of intervention effects 2-months postintervention...
November 1, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/29074518/bi-modal-stimulation-in-the-treatment-of-tinnitus-a-study-protocol-for-an-exploratory-trial-to-optimise-stimulation-parameters-and-patient-subtyping
#12
Shona D'Arcy, Caroline Hamilton, Stephen Hughes, Deborah A Hall, Sven Vanneste, Berthold Langguth, Brendan Conlon
INTRODUCTION: Tinnitus is the perception of sound in the absence of a corresponding external acoustic stimulus. Bimodal neuromodulation is emerging as a promising treatment for this condition. The main objectives of this study are to investigate the relevance of interstimulus timing and the choices of acoustic and tongue stimuli for a proprietary bimodal (auditory and somatosensory) neuromodulation device, as well as to explore whether specific subtypes of patients are differentially responsive to this novel intervention for reducing the symptoms of chronic tinnitus...
October 25, 2017: BMJ Open
https://www.readbyqxmd.com/read/29071058/the-short-hyperacusis-questionnaire-a-tool-for-the-identification-and-measurement-of-hyperacusis-in-the-italian-tinnitus-population
#13
Federica Tortorella, Silva Pavaci, Alessandra Barbara Fioretti, Francesco Masedu, Maria Lauriello, Alberto Eibenstein
No abstract text is available yet for this article.
July 18, 2017: Audiology Research
https://www.readbyqxmd.com/read/29043888/effect-of-sound-generator-on-tinnitus-and-hyperacusis
#14
Jung Mee Park, Woo Jin Kim, Jin Bu Ha, Jung Ju Han, So Young Park, Shi Nae Park
OBJECTIVE: Sound generator (SG) plays a role as effective sound therapy of tinnitus retaining therapy (TRT) in patients with severe tinnitus (Category 1) or hyperacusis (Category 3). This study was performed to evaluate the therapeutic effect of SGs. METHODS: A total of 120 tinnitus patients who visited our tinnitus clinic and were treated with SG along with TRT from January 2008 to December 2016 were included. The patients were divided into two groups by tinnitus category; 78 patients of category 1 and 42 patients of category 3...
October 18, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28859531/hearing-disorder-from-music-a-neglected-dysfunction
#15
Annett Szibor, Petteri Hyvärinen, Jarmo Lehtimäki, Ulla Pirvola, Matti Ylikoski, Antti Mäkitie, Antti Aarnisalo, Jukka Ylikoski
CONCLUSION: Music-induced acute acoustic trauma is not inevitably linked to hearing dysfunction as validated by conventional pure tone audiometry. Tinnitus is often in combination with hyperacusis. Our results point at 'silent hearing loss' as the underlying pathology, having afferent nerve terminal damage rather than hair cell loss as the structural correlate. OBJECTIVES: Exposure to loud music is one of the most common causes of acute acoustic trauma, which adolescents and teenagers experience by voluntary exposure to loud music of sound levels up to 110 dB(A)...
August 31, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28841656/clinical-characteristics-of-patients-with-tinnitus-evaluated-with-the-tinnitus-sample-case-history-questionnaire-in-japan-a-case-series
#16
Takashi Kojima, Sho Kanzaki, Naoki Oishi, Kaoru Ogawa
BACKGROUND: The Tinnitus Sample Case History Questionnaire was determined as a standardized questionnaire for obtaining patient case histories and for characterizing patients into subgroups at the Tinnitus Research Initiative in 2006. In this study, we developed a Japanese version of this questionnaire for evaluating the clinical characteristics of patients with tinnitus. The Japanese version of the questionnaire will be available for evaluating treatments for tinnitus and for comparing data on tinnitus in research centers...
2017: PloS One
https://www.readbyqxmd.com/read/28810267/incidence-of-discomfort-during-pure-tone-audiometry-and-measurement-of-uncomfortable-loudness-levels-among-people-seeking-help-for-tinnitus-and-or-hyperacusis
#17
Hashir Aazh, Brian C J Moore
Purpose: The aim of this study was to assess the proportion of patients seen in a tinnitus and hyperacusis therapy clinic for whom presentation levels based on the British Society of Audiology (BSA)-recommended procedures for pure-tone audiometry and determination of uncomfortable loudness levels (ULLs) exceed ULLs, leading to discomfort during administration of these procedures. Method: This was a retrospective cross-sectional study of 362 consecutive patients who attended a National Health Service audiology clinic for tinnitus and/or hyperacusis rehabilitation...
September 18, 2017: American Journal of Audiology
https://www.readbyqxmd.com/read/28711622/prolonged-low-level-noise-induced-plasticity-in-the-peripheral-and-central-auditory-system-of-rats
#18
Adam M Sheppard, Guang-Di Chen, Senthilvelan Manohar, Dalian Ding, Bo-Hua Hu, Wei Sun, Jiwei Zhao, Richard Salvi
Prolonged low-level noise exposure alters loudness perception in humans, presumably by decreasing the gain of the central auditory system. Here we test the central gain hypothesis by measuring the acute and chronic physiologic changes at the level of the cochlea and inferior colliculus (IC) after a 75-dB SPL, 10-20-kHz noise exposure for 5weeks. The compound action potential (CAP) and summating potential (SP) were used to assess the functional status of the cochlea and 16 channel electrodes were used to measure the local field potentials (LFP) and multi-unit spike discharge rates (SDR) from the IC immediately after and one-week post-exposure...
September 17, 2017: Neuroscience
https://www.readbyqxmd.com/read/28705607/noise-induced-hearing-loss-induces-loudness-intolerance-in-a-rat-active-sound-avoidance-paradigm-asap
#19
Senthilvelan Manohar, Jaclyn Spoth, Kelly Radziwon, Benjamin D Auerbach, Richard Salvi
Hyperacusis is a loudness hypersensitivity disorder in which moderate-intensity sounds are perceived as extremely loud, aversive and/or painful. To assess the aversive nature of sounds, we developed an Active Sound Avoidance Paradigm (ASAP) in which rats altered their place preference in a Light/Dark shuttle box in response to sound. When no sound (NS) was present, rats spent more than 95% of the time in the Dark Box versus the transparent Light Box. However, when a 60 or 90 dB SPL noise (2-20 kHz, 2-8 kHz, or 16-20 kHz bandwidth) was presented in the Dark Box, the rats'' preference for the Dark Box significantly decreased...
September 2017: Hearing Research
https://www.readbyqxmd.com/read/28703883/associations-between-cardiovascular-disease-and-its-risk-factors-with-hearing-loss-a-cross-sectional-analysis
#20
Hsern Ern Ivan Tan, Nick Si Rui Lan, Matthew William Knuiman, Mark Laurence Divitini, De Wet Swanepoel, Michael Hunter, Christopher Gerard Brennan-Jones, Joseph Hung, Robert Henry Eikelboom, Peter Luke Santa Maria
OBJECTIVES: To investigate the relationship between hearing loss and cardiovascular disease risk factors. DESIGN: Cross-sectional study. METHODS: Participants were recruited between May 2010 and December 2015 and answered a health and risk factor questionnaire. Physical and biochemical assessments were performed. SETTING: A community based population. PARTICIPANTS: 5,107 participants born within the years 1946-1964 enrolled in the Busselton Healthy Ageing Study...
July 13, 2017: Clinical Otolaryngology
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