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Hearing loss and dementia

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https://www.readbyqxmd.com/read/29663531/identification-of-variants-in-the-mitochondrial-lysine-trna-mt-tk-gene-in-myoclonic-epilepsy-pathogenicity-evaluation-and-structural-characterization-by-in-silico-approach
#1
Muhammad S Nadeem, Habib Ahmad, Kaleemuddin Mohammed, Khushi Muhammad, Inam Ullah, Othman A S Baothman, Nasir Ali, Firoz Anwar, Mazin A Zamzami, Abdul Rauf Shakoori
Variations in mitochondrial genes have an established link with myoclonic epilepsy. In the present study we evaluated the nucleotide sequence of MT-TK gene of 52 individuals from 12 unrelated families and reported three variations in 2 of the 13 epileptic patients. The DNA sequences coding for MT-TK gene were sequenced and mutations were detected in all participants. The mutations were further analyzed by the in silico analysis and their structural and pathogenic effects were determined. All the investigated patients had symptoms of myoclonus, 61...
April 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29661329/hearing-loss-in-the-elderly
#2
REVIEW
Rohan Patel, Brian J McKinnon
Presbycusis, or age-related hearing loss (ARHL), is the result of physiologic and pathologic changes associated with advancing age. ARHL presents typically with a high-frequency hearing loss, which contributes to greater trouble hearing consonants within words. Consonants convey the bulk of meaning within a word, and this loss of linguistic information results in complaints associated with ARHL. Hearing aids and cochlear implants significantly improve the lives of older adults with hearing loss, in particular, those with depression and dementia...
May 2018: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/29656010/age-related-defects-in-short-term-plasticity-are-reversed-by-acetyl-l-carnitine-at-the-mouse-calyx-of-held
#3
Mahendra Singh, Pedro Miura, Robert Renden
Hearing acuity and sound localization are affected by aging and may contribute to cognitive dementias. Although loss of sensorineural conduction is well documented to occur with age, little is known regarding short-term synaptic plasticity in central auditory nuclei. Age-related changes in synaptic transmission properties were evaluated at the mouse calyx of Held, a sign-inverting relay synapse in the circuit for sound localization, in juvenile adults (1 month old) and late middle-aged (18-21 months old) mice...
March 21, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29649050/temporal-bone-histopathology-in-cockayne-syndrome
#4
Ophir Handzel, Joseph B Nadol
: Cockayne syndrome (CS) is a rare autosomal recessive syndrome resulting in defective DNA repair. Its features include cachectic dwarfism, hearing loss, skin hypersensitivity to sunlight, premature aging, and dementia. Presented is a right temporal bone of a patient who died at the age of 29 years. The clinical course was compatible with type 1 CS, the classical form. Homozygous missense variant in the ERCC6 gene (Excision Repair Cross-Complementation group 6) was found, compatible with CS complementation group B...
April 11, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29564993/risk-of-dementia-associated-with-psychotic-disorders-in-later-life-the-health-in-men-study-hims
#5
Osvaldo P Almeida, Andrew H Ford, Graeme J Hankey, Bu B Yeap, Jonathan Golledge, Leon Flicker
BACKGROUND: Recent research has identified several potentially modifiable risk factors for dementia, including mental disorders. Psychotic disorders, such as schizophrenia and delusional disorder, have also been associated with increased risk of cognitive impairment and dementia, but currently available data difficult to generalise because of bias and confounding. We designed the present study to investigate if the presence of a psychotic disorder increased the risk of incident dementia in later life...
March 22, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29556173/impact-of-aging-on-the-auditory-system-and-related-cognitive-functions-a-narrative-review
#6
REVIEW
Dona M P Jayakody, Peter L Friedland, Ralph N Martins, Hamid R Sohrabi
Age-related hearing loss (ARHL), presbycusis, is a chronic health condition that affects approximately one-third of the world's population. The peripheral and central hearing alterations associated with age-related hearing loss have a profound impact on perception of verbal and non-verbal auditory stimuli. The high prevalence of hearing loss in the older adults corresponds to the increased frequency of dementia in this population. Therefore, researchers have focused their attention on age-related central effects that occur independent of the peripheral hearing loss as well as central effects of peripheral hearing loss and its association with cognitive decline and dementia...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29515619/assessment-of-dementia-in-individuals-with-dual-sensory-loss-application-of-a-tactile-test-battery
#7
Peter Bruhn, Jesper Dammeyer
Background/Aims: Individuals with dual sensory loss (DSL) are more likely to experience cognitive decline with age than individuals without sensory loss. Other studies have pointed to the challenges in assessing cognitive abilities in individuals with DSL, as most existing instruments rely on use of vision and hearing. The aim of this study was to develop and evaluate a Tactile Test Battery (TTB) for cognitive assessment in individuals with DSL. Method: Twenty elderly individuals with DSL, 20 with diagnosed dementia, and 20 without dementia or DSL (controls) completed the following tactile tests developed for the present study: Spatial learning, Spatial recall, Tactile form board, Clock reading, and Naming...
January 2018: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/29410592/the-relationships-between-cognitive-function-and-hearing-loss-among-the-elderly
#8
MyungJin Huh
[Purpose] Research related to dementia has gained momentum in South Korea and studies have found that the auditory sense affects dementia. This study aims to examine the relationship between the decline in hearing function and the overall cognitive function among the elderly. [Subjects and Methods] Eighty-two older adults aged 65-90 years (mean age: 79.3, SD: 5.2) participated. The Korean Mini-Mental State Examination was used to assess cognitive function. Further, to assess the hearing function, pure-tone audiometry was performed prior to the cognitive function test...
January 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29319875/association-between-sensory-impairment-and-dementia-in-older-adults-evidence-from-china
#9
Yanan Luo, Ping He, Chao Guo, Gong Chen, Ning Li, Xiaoying Zheng
OBJECTIVES: To determine the association between sensory impairment and dementia in Chinese older adults. DESIGN: Cross-sectional. SETTING: Older adults in 31 provinces of China. PARTICIPANTS: Individuals aged 65 and older (N = 250,752). MEASUREMENTS: Psychiatrists ascertained dementia based on the International Classification of Diseases, 10th Revision. Sensory impairment was measured as only hearing impairment, only vision impairment, and combined sensory impairment (combined hearing and vision impairment)...
March 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29304204/death-depression-disability-and-dementia-associated-with-self-reported-hearing-problems-a-25-year-study
#10
Hélène Amieva, Camille Ouvrard, Céline Meillon, Laetitia Rullier, Jean-François Dartigues
Background: Hearing loss in older adults is suspected to play a role in social isolation, depression, disability, lower quality of life and risk of dementia. Such suspected associations still need to be consolidated with additional research. With a particularly long follow-up, this study assessed the relationship between hearing status and four major adverse health events: death, dementia, depression, and disability. Methods: Prospective community-based study of 3777 subjects aged ≥ 65 followed-up for 25 years...
January 3, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29279726/hearing-aids-indications-technology-adaptation-and-quality-control
#11
REVIEW
Ulrich Hoppe, Gerhard Hesse
Hearing loss can be caused by a number of different pathological conditions. Some of them can be successfully treated, mainly by surgery, depending on the individual's disease process. However, the treatment of chronic sensorineural hearing loss with damaged cochlear structures usually needs hearing rehabilitation by means of technical amplification. During the last two decades tremendous improvements in hearing aid technology led to a higher quality of the hearing rehabilitation process. For example, due to sophisticated signal processing acoustic feedback could be reduced and hence open fitting options are available even for more subjects with higher degrees of hearing loss...
2017: GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery
https://www.readbyqxmd.com/read/29222544/association-of-age-related-hearing-loss-with-cognitive-function-cognitive-impairment-and-dementia-a-systematic-review-and-meta-analysis
#12
David G Loughrey, Michelle E Kelly, George A Kelley, Sabina Brennan, Brian A Lawlor
Importance: Epidemiologic research on the possible link between age-related hearing loss (ARHL) and cognitive decline and dementia has produced inconsistent results. Clarifying this association is of interest because ARHL may be a risk factor for outcomes of clinical dementia. Objectives: To examine and estimate the association between ARHL and cognitive function, cognitive impairment, and dementia through a systematic review and meta-analysis. Data Sources and Study Selection: A search of PubMed, the Cochrane Library, EMBASE, and SCOPUS from inception to April 15, 2016, with cross-referencing of retrieved studies and personal files for potentially eligible studies was performed...
February 1, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29202654/sensation-and-psychiatry-linking-age-related-hearing-loss-to-late-life-depression-and-cognitive-decline
#13
Bret R Rutherford, Katharine Brewster, Justin S Golub, Ana H Kim, Steven P Roose
Recent research has linked age-related hearing loss to impaired performance across cognitive domains and increased risk for dementia diagnosis. The data linking hearing impairment to incident late-life depression are more mixed but suggest that diminished hearing does increase risk for depression. Behavioral mechanisms may explain these associations, such as the withdrawal of older adults from situations in which they may have difficulty hearing and communicating, which may contribute to the development of social isolation, loneliness, and consequent cognitive decline and depression...
March 1, 2018: American Journal of Psychiatry
https://www.readbyqxmd.com/read/29076447/aging-in-place-our-house-is-a-very-very-very-fine-house
#14
Jeannette Y Wick
As 10,000 American baby boomers turn 65 years of age every day between 2017 and 2030, society needs to help our aging population find ways to handle the restrictions and limitations that come with increasing age: visual impairment, hearing loss, osteoarthritis, dementia, and other conditions common in older adults. Institutional or long-term care for elderly individuals costs an average of $82,000 to $92,000 per person per year and varies by location. Care in an assisted living facility costs $43,500 per person annually...
October 1, 2017: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/29067347/a-randomized-feasibility-pilot-trial-of-hearing-treatment-for-reducing-cognitive-decline-results-from-the-aging-and-cognitive-health-evaluation-in-elders-pilot-study
#15
Jennifer A Deal, Marilyn S Albert, Michelle Arnold, Shrikant I Bangdiwala, Theresa Chisolm, Sonia Davis, Ann Eddins, Nancy W Glynn, Adele M Goman, Melissa Minotti, Thomas Mosley, George W Rebok, Nicholas Reed, Elizabeth Rodgers, Victoria Sanchez, A Richey Sharrett, Josef Coresh, Frank R Lin
INTRODUCTION: Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. METHODS: A 40-person (aged 70-84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254...
September 2017: Alzheimer's & Dementia: Translational Research & Clinical Interventions
https://www.readbyqxmd.com/read/29066873/application-of-a-computer-based-neurocognitive-assessment-battery-in-the-elderly-with-and-without-hearing-loss
#16
Christiane Völter, Lisa Götze, Michael Falkenstein, Stefan Dazert, Jan Peter Thomas
INTRODUCTION: Due to demographic changes, the number of people suffering not only from dementia illness but also from hearing impairment with the need for hearing rehabilitation have increased noticeably. Even with the association between hearing, age, and cognitive decline being well known, this issue has so far not played an important role in daily clinical Ear Nose Throat settings. The aim of the present study was to evaluate the use of a computer-based battery of tests of neurocognitive abilities in older patients with and without hearing loss...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28919117/global-regional-and-national-incidence-prevalence-and-years-lived-with-disability-for-328-diseases-and-injuries-for-195-countries-1990-2016-a-systematic-analysis-for-the-global-burden-of-disease-study-2016
#17
(no author information available yet)
BACKGROUND: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. METHODS: We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences...
September 16, 2017: Lancet
https://www.readbyqxmd.com/read/28894825/hearing-loss-as-a-risk-factor-for-dementia-a-systematic-review
#18
REVIEW
Rhett S Thomson, Priscilla Auduong, Alexander T Miller, Richard K Gurgel
OBJECTIVES: To review evidence of hearing loss as a risk factor for dementia. Data Sources: PubMed Review methods: A systematic review was conducted using the PubMed database using the search terms (hearing loss OR presbycusis) AND (dementia OR cognitive decline). Initially, 488 articles were obtained. Only those studies evaluating an association between hearing loss and incident dementia or cognitive decline were included in the analysis. This resulted in 17 articles which were thoroughly evaluated with consideration for study design, method for determining hearing loss and cognitive status, relevant covariates and confounding factors, and key findings...
April 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/28806332/linking-deafness-and-dementia-challenges-and-opportunities
#19
Vincent Y W Lin, Sandra E Black
: The rising incidence of dementia locally and worldwide has now reached a critical level. The associated costs associated with these individuals will ultimately be untenable to most societies. Furthermore there is a paucity of highly effective treatments. However, the recent discovery of the association of hearing loss and dementia may open many potential opportunities. Although we still are acquiring knowledge on the pathophysiology of this association, clinicians are hopeful that our current highly effective treatments of hearing loss may ultimately be shown to have a positive effect on those with dementia...
September 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28805100/older-adults-with-a-combination-of-vision-and-hearing-impairment-experience-higher-rates-of-cognitive-impairment-functional-dependence-and-worse-outcomes-across-a-set-of-quality-indicators
#20
Jacob G S Davidson, Dawn M Guthrie
OBJECTIVES: Hearing and vision impairment were examined across several health-related outcomes and across a set of quality indicators (QIs) in home care clients with both vision and hearing loss (or dual sensory impairment [DSI]). METHOD: Data collected using the Resident Assessment Instrument for Home Care (RAI-HC) were analyzed in a sample of older home care clients. The QIs represent the proportion of clients experiencing negative outcomes (e.g., falls, social isolation)...
August 1, 2017: Journal of Aging and Health
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