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https://www.readbyqxmd.com/read/28811917/drug-information-update-lithium-and-chronic-kidney-disease-debates-and-dilemmas
#1
Sumeet Gupta, Udayan Khastgir
Lithium is an established treatment for bipolar disorder and an augmenting agent for treatment-resistant depression. Despite awareness of renal adverse effects, including chronic kidney disease, for the past five decades, there has been a lack of research evidence. This has led to debates around the existence and magnitude of the risk. This article discusses the current evidence base regarding the link between lithium and chronic kidney disease, monitoring of renal functions and its clinical implications.
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28811916/drug-information-update-atypical-antipsychotics-and-neuroleptic-malignant-syndrome-nuances-and-pragmatics-of-the-association
#2
Siddharth Sarkar, Nitin Gupta
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal adverse event associated with the use of antipsychotics. Although atypical antipsychotics were initially considered to carry no risk of NMS, reports have accumulated over time implicating them in NMS causation. Almost all atypical antipsychotics have been reported to be associated with NMS. The clinical profile of NMS caused by certain atypical antipsychotics such as clozapine has been reported to be considerably different from the NMS produced by typical antipsychotics, with diaphoresis encountered more commonly, and rigidity and tremor encountered less frequently...
August 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28790076/implementation-of-a-formulary-management-process
#3
Lauren I Karel, Dennis R Delisle, Ellena A Anagnostis, Cindy J Wordell
PURPOSE: The application of lean methodology in an initiative to redesign the formulary maintenance process at an academic medical center is described. SUMMARY: Maintaining a hospital formulary requires clear communication and coordination among multiple members of the pharmacy department. Using principles of lean methodology, pharmacy department personnel within a multihospital health system launched a multifaceted initiative to optimize formulary management systemwide...
August 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28760153/an-overview-of-forensic-drug-testing-methods-and-their-suitability-for-harm-reduction-point-of-care-services
#4
REVIEW
Lane Harper, Jeff Powell, Em M Pijl
Given the current opioid crisis around the world, harm reduction agencies are seeking to help people who use drugs to do so more safely. Many harm reduction agencies are exploring techniques to test illicit drugs to identify and, where possible, quantify their constituents allowing their users to make informed decisions. While these technologies have been used for years in Europe (Nightlife Empowerment & Well-being Implementation Project, Drug Checking Service: Good Practice Standards; Trans European Drugs Information (TEDI) Workgroup, Factsheet on Drug Checking in Europe, 2011; European Monitoring Centre for Drugs and Drug Addiction, An Inventory of On-site Pill-Testing Interventions in the EU: Fact Files, 2001), they are only now starting to be utilized in this context in North America...
July 31, 2017: Harm Reduction Journal
https://www.readbyqxmd.com/read/28760141/pharmacovigilance-in-israel-tools-processes-and-actions
#5
Eyal Schwartzberg, Matitiahu Berkovitch, Dorit Dil Nahlieli, Joseph Nathan, Einat Gorelik
BACKGROUND: Due to the limited safety data available at the time that a new medication is first marketed, it is essential to continue the collection and monitoring of safety data about adverse drug reactions (ADRs) during the medication's life cycle. This activity, known as pharmacovigilance (PV), is performed worldwide by the pharmaceutical industry as well as by regulatory agencies. In 2012, the Israeli Ministry of Health (MOH) established a Pharmacovigilance and Drug Information Department...
August 1, 2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28756965/drug-related-problems-in-geriatric-rehabilitation-patients-after-discharge-a-prevalence-analysis-and-clinical-case-scenario-based-pilot-study
#6
Johanna Freyer, Lucie Hueter, Lysann Kasprick, Thomas Frese, Ralf Sultzer, Susanne Schiek, Thilo Bertsche
BACKGROUND: Geriatric patients bear a high risk for having drug-related problems (DRPs). Transitions of care are especially susceptible to these DRPs. OBJECTIVE: To highlight the prevalence of DRPs in geriatric patients' post-discharge medication lists and to assess physicians' ability to identify DRPs by using clinical case scenarios. METHODS: A sequential prospective mixed-method study was performed. In a DRP prevalence analysis, an expert panel of clinical pharmacists analyzed DRPs in post-discharge medication lists of long-term hospitalized patients from a German inpatient geriatric rehabilitation center...
July 25, 2017: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28753045/an-internet-based-survey-of-96-german-speaking-users-of-bath-salts-frequent-complications-risky-sexual-behavior-violence-and-delinquency
#7
Sabrina Schmoll, Katrin Romanek, Raphael Stich, Elias Bekka, Jochen Stenzel, Stefanie Geith, Florian Eyer, Christian Rabe
OBJECTIVE: To define the demographics of German-speaking "bath salt" users. DESIGN: Prospective web-based survey of volunteer users of "bath salts". Subject recruitment/exclusion: Participation was solicited by posts in web forums frequented by users of synthetic cathinones. An invitation to participate was also disseminated via regional drug information centers. Responses were discarded if participants refused data analysis, provided incomplete surveys, were under 18 years of age (five cases), and in case of clearly improbable answers (i...
July 28, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28728494/the-clinical-significance-of-qt-prolongation-associated-with-tamoxifen-a-review-of-the-literature
#8
Katherine Fung, Julia Imeson, Frances Cusano
Objective To review the literature discussing QT prolongation associated with the use of tamoxifen in order to evaluate the clinical significance. Data sources A search of PubMed (1946 to 2017), MEDLINE (1946 to 2017) and EMBASE (1947 to 2017) was performed using a combination of the following search terms: tamoxifen, estrogen antagonist, selective estrogen receptor modulator, QT prolongation, QT interval, long QT syndrome and torsades de pointes. All searches were limited to human subjects. Reference lists of the literature found were also reviewed but did not reveal any further articles...
January 1, 2017: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/28722678/optimal-adjuvant-chemotherapy-for-resected-pancreatic-adenocarcinoma-a-systematic-review-and-network-meta-analysis
#9
Jian-Bo Xu, Bin Jiang, Ya Chen, Fu-Zhen Qi, Jian-Huai Zhang, Hang Yuan
Adjuvant chemotherapy improves survival in patients with resected pancreatic cancer but the optimal regimen remains unclear. We aim to compare all possible adjuvant chemotherapy in terms of overall survival and toxic effects. Pubmed, Trial registries and Cochrane library databases for randomized controlled trials were searched until November 2016. Thirteen trials were included for network analysis and the hazard ratios (HRs) for survival and odds ratios for toxic effects were assessed via Aggregate Data Drug Information System software...
July 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28722159/commentary-changes-are-still-needed-on-multiple-co-primary-endpoints
#10
Christy Chuang-Stein, Jianjun David Li
The Food and Drug Administration in the United States issued a much-awaited draft guidance on 'Multiple Endpoints in Clinical Trials' in January 2017. The draft guidance is well written and contains consistent message on the technical implementation of the principles laid out in the guidance. In this commentary, we raise a question on applying the principles to studies designed from a safety perspective. We then direct our attention to issues related to multiple co-primary endpoints. In a paper published in the Drug Information Journal in 2007, Offen et al...
July 19, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28690696/nurses-attitudes-and-behaviors-on-patient-medication-education
#11
Jane F Bowen, Melissa E Rotz, Brandon J Patterson, Sanchita Sen
BACKGROUND: Medication education is vital for positive patient outcomes. However, there is limited information about optimal medication education by nurses during hospitalization and care transitions. OBJECTIVE: Examine nurses' attitudes and behaviors regarding the provision of patient medication education. The secondary objectives were to determine if nurses' medication education attitudes explain their behaviors, describe nurses' confidence in patient medication knowledge and abilities, and identify challenges to and improvements for medication education...
April 2017: Pharmacy Practice
https://www.readbyqxmd.com/read/28656452/homeless-women-with-schizophrenia-reported-lower-adherence-to-their-medication-than-men-results-from-the-french-housing-first-experience
#12
A Tinland, K Zemmour, P Auquier, M Boucekine, V Girard, S Loubière, G Fond, Laurent Boyer
OBJECTIVE: The aim of this study was to investigate the factors associated with non-adherence to medication in a large multi-center sample of homeless schizophrenia (HSZ) patients. METHODS: This multi-center study was conducted in four French cities: Lille, Marseille, Paris, and Toulouse. In addition to the Medication Adherence Rating Scale (MARS), sociodemographic information, history of homelessness, illness severity using the Modified Colorado Symptom Index (MCSI) and the Multnomah Community Integration Scale (MCAS), and drug information were collected...
June 27, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28652818/adaptation-of-the-european-commission-recommended-user-testing-method-to-patient-medication-information-leaflets-in-japan
#13
Michiko Yamamoto, Hirohisa Doi, Ken Yamamoto, Kazuhiro Watanabe, Tsugumichi Sato, Machi Suka, Takeo Nakayama, Hiroki Sugimori
BACKGROUND: The safe use of drugs relies on providing accurate drug information to patients. In Japan, patient leaflets called Drug Guide for Patients are officially available; however, their utility has never been verified. This is the first attempt to improve Drug Guide for Patients via user testing in Japan. PURPOSE: To test and improve communication of drug information to minimize risk for patients via user testing of the current and revised versions of Drug Guide for Patients, and to demonstrate that this method is effective for improving Drug Guide for Patients in Japan...
2017: Drug, Healthcare and Patient Safety
https://www.readbyqxmd.com/read/28651624/multifaceted-interventions-for-improving-spontaneous-reporting-of-adverse-drug-reactions-in-a-general-hospital-in-china
#14
Huan Fang, Xiaowen Lin, Jun Zhang, Zhen Hong, Kenji Sugiyama, Takao Nozaki, Tetsuro Sameshima, Susumu Kobayashi, Hiroki Namba, Tetsuya Asakawa
BACKGROUND: The present study investigates changes in spontaneous reporting (SR) compliance and ADR patterns following adoption of a new hospital SR system, and multiple interventions designed for its improvement use under modified drug administration guidelines. METHODS: In total, 1389 ADR cases were reviewed. Cases were divided into two groups, cases from period 1 (n = 557, from January 2006 to June 2011) under the old SR system and cases in period 2 (n = 832, from July 2011 to December 2016) under the new SR system with multiple interventions to improve physician SR compliance...
June 26, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28638300/characteristics-of-pediatric-clinical-interventions-documented-by-a-school-of-pharmacy
#15
Lea S Eiland
OBJECTIVES: Documentation of interventions by pharmacists has become a standard of practice in clinical practice sites. Pharmacists' interventions in pediatric practice settings for short periods of time have been reported in the literature. A single study has described faculty and student interventions in the pediatric setting. The objective of this study was to characterize 4 years of interventions by faculty and students of a school of pharmacy that occurred at various pediatric practice sites throughout a state...
May 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28627939/off-label-prescribing-for-children-with-chronic-diseases-in-nigeria-findings-and-implications
#16
Kazeem Adeola Oshikoya, Ibrahim Adekunle Oreagba, Brian Godman, Joseph Fadare, Samuel Orubu, Amos Massele, Idowu Odunayo Senbanjo
BACKGROUND AND AIMS: Prescribing medicines in an off-label manner for children with chronic conditions is sparsely documented, even more so among developing countries. This needs addressing. The objective was to investigate the extent of this prescribing among children with epilepsy, asthma, and sickle cell anaemia in Nigeria. METHODS: Prescriptions for children ≤16 years documented in their case files that attended paediatric clinics in Lagos, Nigeria, for these three conditions between January and October 2015, were reviewed retrospectively to extract data on the medicines prescribed...
June 19, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28622641/u-s-drug-shortages-for-medications-used-in-adult-critical-care-2001-2016
#17
Maryann Mazer-Amirshahi, Munish Goyal, Suleman A Umar, Erin R Fox, Mark Zocchi, Kristy L Hawley, Jesse M Pines
PURPOSE: We describe trends in U.S. shortages impacting critical care drugs from 2001 to 2016. MATERIALS AND METHODS: Shortages within the scope of critical care were identified using data from the University of Utah Drug Information Services. Shortage characteristics were described using standard descriptive statistics and regression analysis. RESULTS: Of 1969 shortages reported, 1004 (51%) were for drugs used in critical care. New shortages fell from 2001 to 2004, then increased, peaking in 2011 (116)...
June 9, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28584654/drug-information-update-unconventional-treatment-strategies-for-schizophrenia-polypharmacy-and-heroic-dosing
#18
Bret A Moore, Debbi A Morrissette, Jonathan M Meyer, Stephen M Stahl
The majority of patients respond to antipsychotic monotherapy at standard doses, but a subset of patients will require more heroic measures that include antipsychotic polypharmacy and high-dose monotherapy. Indeed, research has shown that roughly 30% of patients with psychosis are prescribed multiple antipsychotic medications. We discuss the potential benefits and challenges of these approaches and provide a rationale for why and when they should be utilised.
June 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/28557844/child-deaths-of-undetermined-intent-an-analysis-of-circumstances-using-illinois-violent-death-reporting-system-data
#19
Han-Wei Wu, Suzanne G McLone, Maryann Mason, Karen Sheehan
BACKGROUND: There is little information available about the circumstances surrounding the deaths of children aged 0 to 14 in which the manner of death is of undetermined intent. METHODS: We analyzed data collected in the Illinois Violent Death Reporting System (IVDRS) to describe victim demographics, location of injury, seasonality, day of week, and circumstances surrounding the victims' deaths. RESULTS: From 2005 to 2010 in Cook County, Illinois, 192 cases were identified of children aged 0-14 years, in which the manner of death was of undetermined intent...
May 25, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28549568/using-visual-analytics-for-presenting-comparative-information-on-new-drugs
#20
Jean-Baptiste Lamy, Hélène Berthelot, Madeleine Favre, Adrien Ugon, Catherine Duclos, Alain Venot
OBJECTIVE: When a new drug is marketed, physicians must decide whether they will consider it for their future practice. However, information about new drugs can be biased or hard to find. In this work, our objective was to study whether visual analytics could be used for comparing drug properties such as contraindications and adverse effects, and whether this visual comparison can help physicians to forge their own well-founded opinions about a new drug. MATERIALS AND METHODS: First, an ontology for comparative drug information was designed, based on the expectations expressed during focus groups comprised of physicians...
July 2017: Journal of Biomedical Informatics
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