keyword
MENU ▼
Read by QxMD icon Read
search

"drug information"

keyword
https://www.readbyqxmd.com/read/28296354/cattle-cancer-treatment-treasury-with-linked-evidence-an-integrated-knowledge-base-for-personalized-oncology-research-and-practice
#1
E Soysal, H-J Lee, Y Zhang, L-C Huang, X Chen, Q Wei, W Zheng, J T Chang, T Cohen, J Sun, H Xu
Despite the existence of various databases cataloging cancer drugs, there is an emerging need to support the development and application of personalized therapies, where an integrated understanding of the clinical factors and drug mechanism of action and its gene targets is necessary. We have developed CATTLE (CAncer Treatment Treasury with Linked Evidence), a comprehensive cancer drug knowledge base providing information across the complete spectrum of the drug life cycle. The CATTLE system collects relevant data from 22 heterogeneous databases, integrates them into a unified model centralized on drugs, and presents comprehensive drug information via an interactive web portal with a download function...
March 2017: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/28287200/-medicines-if-their-added-value-is-not-made-explicit
#2
Giulio Formoso, Maria Font Pous
Information on added therapeutic value of medicines should represent the basis for therapeutic decisions and ideally, before of that, for drug registration. A recent study assessed the availability and quality of such information provided by Medicines Regulatory Authorities and other national public health institutions in 8 European countries, and of tools facilitating the implementation of such information. This study highlighted for UK and Germany quite an advanced framework of evidence-based, comparative drug information for health professionals, decision-makers and for the general public...
February 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28286821/smartphones-and-medical-applications-in-the-emergency-department-daily-practice
#3
Amirhosein Jahanshir, Ehsan Karimialavijeh, Hojjat Sheikh, Motahar Vahedi, Mehdi Momeni
INTRODUCTION: Medical applications help physicians to make more rapid and evidence based decisions that may provide better patient care. This study aimed to determine the extent to which smart phones and medical applications are integrated in the emergency department daily practice. METHOD: In a cross sectional study, a modified standard questionnaire (Payne et al.) consisting of demographic data and information regarding quality and quantity of smartphone and medical app utilization was sent to emergency-medicine residents and interns twice (two weeks apart), in January 2015...
2017: Emergency (Tehran, Iran)
https://www.readbyqxmd.com/read/28281911/comparing-oncology-clinical-programs-by-use-of-innovative-designs-and-expected-net-present-value-optimization-which-adaptive-approach-leads-to-the-best-result
#4
Tom Parke, Olga Marchenko, Vladimir Anisimov, Anastasia Ivanova, Christopher Jennison, Inna Perevozskaya, Guochen Song
Designing an oncology clinical program is more challenging than designing a single study. The standard approaches have been proven to be not very successful during the last decade; the failure rate of Phase 2 and Phase 3 trials in oncology remains high. Improving a development strategy by applying innovative statistical methods is one of the major objectives of a drug development process. The oncology sub-team on Adaptive Program under the Drug Information Association Adaptive Design Scientific Working Group (DIA ADSWG) evaluated hypothetical oncology programs with two competing treatments and published the work in the Therapeutic Innovation and Regulatory Science journal in January 2014...
February 7, 2017: Journal of Biopharmaceutical Statistics
https://www.readbyqxmd.com/read/28244609/preparedness-of-newly-qualified-doctors-in-ireland-for-prescribing-in-clinical-practice
#5
S E Geoghegan, E Clarke, D Byrne, D Power, D Moneley, J Strawbridge, D J P Williams
AIM: To investigate the level of preparedness of newly qualified Irish trained doctors for prescribing, and to investigate their attitudes towards prescribing and prescribing education, through a national survey. METHODS: A 29 item online survey was distributed to 686 newly qualified doctors one month prior to the completion of their first year of clinical practice (internship). Only graduates from Irish medical schools were included. RESULTS: The response rate was 20...
February 28, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28243416/developing-a-national-formulary-based-on-a-unified-payment-system-in-iran
#6
Maryam Ahmadi, Morteza Amraei, Mahnaz Samadbeik
INTRODUCTION: The national formulary plays an important role in increasing access to medicine and correct drug information based on national considerations. However, this study aimed to provide a model for development of national formulary based on a unified payment system in Iran. METHODS: This study used a combination of descriptive, comparative, and qualitative methods. It was an applied developmental study in 2016. The data were collected using a form based on the World Health Organization's (WHO) standard model for national formulary...
January 2017: Electronic Physician
https://www.readbyqxmd.com/read/28237406/pharmacogenetics-based-personalized-therapy-levels-of-evidence-and-recommendations-from-the-french-network-of-pharmacogenetics-rnpgx
#7
Nicolas Picard, Jean-Christophe Boyer, Marie-Christine Etienne-Grimaldi, Chantal Barin-Le Guellec, Fabienne Thomas, Marie-Anne Loriot
More than 50 laboratories offer pharmacogenetic testing in France. These tests are restricted to a limited number of indications: prevention of serious adverse drug reactions; choice of most appropriate therapeutic option; dose adjustment for a specific drug. A very small proportion of these tests are mentioned in drug information labeling and the data provided (if any) are generally insufficient to ascertain whether a test is required and if it is useful. This article discusses the rationale for evaluating the performance and clinical usefulness of pharmacogenetics and provides, on behalf of the French national network of pharmacogenetics (RNPGx), three levels of recommendation for testing: essential, advisable, and possibly helpful...
January 30, 2017: Thérapie
https://www.readbyqxmd.com/read/28228132/information-needs-for-making-clinical-recommendations-about-potential-drug-drug-interactions-a-synthesis-of-literature-review-and-interviews
#8
Katrina M Romagnoli, Scott D Nelson, Lisa Hines, Philip Empey, Richard D Boyce, Harry Hochheiser
BACKGROUND: Drug information compendia and drug-drug interaction information databases are critical resources for clinicians and pharmacists working to avoid adverse events due to exposure to potential drug-drug interactions (PDDIs). Our goal is to develop information models, annotated data, and search tools that will facilitate the interpretation of PDDI information. To better understand the information needs and work practices of specialists who search and synthesize PDDI evidence for drug information resources, we conducted an inquiry that combined a thematic analysis of published literature with unstructured interviews...
February 22, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28197684/definition-of-variables-required-for-comprehensive-description-of-drug-dosage-and-clinical-pharmacokinetics
#9
Anna V Medem, Hanna M Seidling, Hans-Georg Eichler, Jens Kaltschmidt, Michael Metzner, Carina M Hubert, David Czock, Walter E Haefeli
PURPOSE: Electronic clinical decision support systems (CDSS) require drug information that can be processed by computers. The goal of this project was to determine and evaluate a compilation of variables that comprehensively capture the information contained in the summary of product characteristic (SmPC) and unequivocally describe the drug, its dosage options, and clinical pharmacokinetics. METHODS: An expert panel defined and structured a set of variables and drafted a guideline to extract and enter information on dosage and clinical pharmacokinetics from textual SmPCs as published by the European Medicines Agency (EMA)...
February 14, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28181321/availability-of-drug-information-on-community-pharmacy-websites-in-tennessee
#10
Nancy Borja-Hart, Kenneth C Hohmeier
OBJECTIVE: This study reports the availability and type of drug information resources on community pharmacy websites in Tennessee. METHODS: A list of pharmacies was obtained from the Tennessee Board of Pharmacy. All community pharmacies located in Tennessee with a website were evaluated. Community pharmacy websites that listed a drug information resource were further analysed into pharmacy type and drug information provider. KEY FINDINGS: One hundred and sixty-nine websites were evaluated...
February 9, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28161750/quality-assessment-of-structure-and-language-elements-of-written-responses-given-by-seven-scandinavian-drug-information-centres
#11
Linda Amundstuen Reppe, Olav Spigset, Jens Peter Kampmann, Per Damkier, Hanne Rolighed Christensen, Ylva Böttiger, Jan Schjøtt
PURPOSE: The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). METHODS: Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The centres were blinded for which queries were part of the study. The responses were assessed qualitatively by six clinical pharmacologists (internal experts) and six general practitioners (GPs, external experts)...
February 5, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28151991/clinical-impact-of-pharmacogenetic-profiling-with-a-clinical-decision-support-tool-in-polypharmacy-home-health-patients-a-prospective-pilot-randomized-controlled-trial
#12
Lindsay S Elliott, John C Henderson, Moni B Neradilek, Nicolas A Moyer, Kristine C Ashcraft, Ranjit K Thirumaran
BACKGROUND: In polypharmacy patients under home health management, pharmacogenetic testing coupled with guidance from a clinical decision support tool (CDST) on reducing drug, gene, and cumulative interaction risk may provide valuable insights in prescription drug treatment, reducing re-hospitalization and emergency department (ED) visits. We assessed the clinical impact of pharmacogenetic profiling integrating binary and cumulative drug and gene interaction warnings on home health polypharmacy patients...
2017: PloS One
https://www.readbyqxmd.com/read/28139458/completeness-accuracy-and-readability-of-wikipedia-as-a-reference-for-patient-medication-information
#13
Danielle M Candelario, Victoria Vazquez, William Jackson, Timothy Reilly
OBJECTIVES: This study determined the completeness, accuracy, and reading level of Wikipedia patient drug information compared with the corresponding United States product insert medication guides. METHODS: From the Top 200 Drugs of 2012, the top 33 medications with medication guides were analyzed. Medication guides and Wikipedia pages were downloaded on a single date to ensure continuity of Wikipedia content. To quantify the completeness and accuracy of the Wikipedia medication information, a scoring system was adapted from previously published work and compared with the 7 core domains of medication guides...
March 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28111172/self-medication-and-self-prescription-with-antibiotics-in-the-middle-east-do-they-really-happen-a-systematic-review-of-the-prevalence-possible-reasons-and-outcomes
#14
REVIEW
Faten Alhomoud, Zainab Aljamea, Reem Almahasnah, Khawlah Alkhalifah, Lama Basalelah, Farah Kais Alhomoud
OBJECTIVES: There has been no review on the prevalence, possible causes, and clinical outcomes of self-medication with antibiotics (SMA) in the Middle East. METHODS: Databases were searched (January 2000 through June 2016) for articles on SMA among adults aged ≥18 years living in the Middle East. A hand search for relevant citations and key journals was also performed. RESULTS: Twenty-two studies were found. The prevalence of SMA ranged from 19% to 82%...
January 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28108896/pharmacophore-based-screening-and-drug-repurposing-exemplified-on-glycogen-synthase-kinase-3-inhibitors
#15
Luminita Crisan, Sorin Avram, Liliana Pacureanu
The current study was conducted to elaborate a novel pharmacophore model to accurately map selective glycogen synthase kinase-3 (GSK-3) inhibitors, and perform virtual screening and drug repurposing. Pharmacophore modeling was developed using PHASE on a data set of 203 maleimides. Two benchmarking validation data sets with focus on selectivity were assembled using ChEMBL and PubChem GSK-3 confirmatory assays. A drug repurposing experiment linking pharmacophore matching with drug information originating from multiple data sources was performed...
January 21, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28097713/pharmacist-industry-relationships
#16
Keene Saavedra, Bonnie O'Connor, Adriane Fugh-Berman
OBJECTIVES: The purpose of this study was to document, in their own words, beliefs and attitudes that American pharmacists have towards the pharmaceutical industry and pharmacists' interactions with industry. METHODS: An ethnographic-style qualitative study was conducted utilizing open-ended interviews with four hospital pharmacists, two independent pharmacists, two retail pharmacists and one administrative pharmacist in the Washington, DC, metropolitan area to elicit descriptions of and attitudes towards pharmacists' relationships with industry...
January 18, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28080146/perceptions-vs-evidence-therapeutic-substitutes-for-antipsychotics-in-patients-with-dementia-in-long-term-care
#17
Brianne L Olivieri-Mui, John W Devlin, Aileen Ochoa, Danielle Schenck, Becky Briesacher
OBJECTIVE: To compare differences between clinician perceptions of therapeutic substitutes for antipsychotics prescribed to patients with dementia in long term care (LTC) and published evidence. METHODS: A mixed-methods approach that included a drug information search, online survey of 55 LTC clinicians and a comprehensive literature review was used. For 41 pharmacologic antipsychotic substitute candidates identified, LTC clinicians rated the likelihood they would substitute each for patients with dementia and identified non-pharmacologic antipsychotic substitutes...
January 12, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28073580/drug-information-by-public-health-and-regulatory-institutions-results-of-an-8-country-survey-in-europe
#18
Giulio Formoso, Maria Font-Pous, Wolf-Dieter Ludwig, David Phizackerley, Dick Bijl, Juan Erviti, Blanka Pospíšilová, Jean Louis Montastruc
PURPOSE: To evaluate the framework of drug information produced by public health and regulatory institutions in Europe. MATERIALS AND METHODS: We carried out a short survey asking editors of ISDB bulletins of the European region to indicate the main sources of drug information provided by public health and regulatory authorities in their countries, the specific kind of information produced and their opinions about strengths and weaknesses of such information. The availability of evaluations about the added therapeutic value of drugs and of tools facilitating the implementation of such information were particularly addressed and checked on the websites of those institutions...
December 29, 2016: Health Policy
https://www.readbyqxmd.com/read/28060329/drug-repurposing-hypothesis-generation-using-the-re-fine-drugs-system
#19
Kelly Regan, Soheil Moosavinasab, Philip Payne, Simon Lin
The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates...
December 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28049901/improvement-of-clinical-skills-through-pharmaceutical-education-and-clinical-research
#20
Junko Ishizaki
 Professors and teaching staff in the field of pharmaceutical sciences should devote themselves to staying abreast of relevant education and research. Similarly those in clinical pharmacies should contribute to the advancement of pharmaceutical research and the development of next generation pharmacists and pharmaceuticals. It is thought that those who work in clinical pharmacies should improve their own skills and expertise in problem-finding and -solving, i.e., "clinical skills". They should be keen to learn new standard treatments based on the latest drug information, and should try to be in a position where collecting clinical information is readily possible...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
keyword
keyword
24127
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"