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https://www.readbyqxmd.com/read/28228132/information-needs-for-making-clinical-recommendations-about-potential-drug-drug-interactions-a-synthesis-of-literature-review-and-interviews
#1
Katrina M Romagnoli, Scott D Nelson, Lisa Hines, Philip Empey, Richard D Boyce, Harry Hochheiser
BACKGROUND: Drug information compendia and drug-drug interaction information databases are critical resources for clinicians and pharmacists working to avoid adverse events due to exposure to potential drug-drug interactions (PDDIs). Our goal is to develop information models, annotated data, and search tools that will facilitate the interpretation of PDDI information. To better understand the information needs and work practices of specialists who search and synthesize PDDI evidence for drug information resources, we conducted an inquiry that combined a thematic analysis of published literature with unstructured interviews...
February 22, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28197684/definition-of-variables-required-for-comprehensive-description-of-drug-dosage-and-clinical-pharmacokinetics
#2
Anna V Medem, Hanna M Seidling, Hans-Georg Eichler, Jens Kaltschmidt, Michael Metzner, Carina M Hubert, David Czock, Walter E Haefeli
PURPOSE: Electronic clinical decision support systems (CDSS) require drug information that can be processed by computers. The goal of this project was to determine and evaluate a compilation of variables that comprehensively capture the information contained in the summary of product characteristic (SmPC) and unequivocally describe the drug, its dosage options, and clinical pharmacokinetics. METHODS: An expert panel defined and structured a set of variables and drafted a guideline to extract and enter information on dosage and clinical pharmacokinetics from textual SmPCs as published by the European Medicines Agency (EMA)...
February 14, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28181321/availability-of-drug-information-on-community-pharmacy-websites-in-tennessee
#3
Nancy Borja-Hart, Kenneth C Hohmeier
OBJECTIVE: This study reports the availability and type of drug information resources on community pharmacy websites in Tennessee. METHODS: A list of pharmacies was obtained from the Tennessee Board of Pharmacy. All community pharmacies located in Tennessee with a website were evaluated. Community pharmacy websites that listed a drug information resource were further analysed into pharmacy type and drug information provider. KEY FINDINGS: One hundred and sixty-nine websites were evaluated...
February 9, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28161750/quality-assessment-of-structure-and-language-elements-of-written-responses-given-by-seven-scandinavian-drug-information-centres
#4
Linda Amundstuen Reppe, Olav Spigset, Jens Peter Kampmann, Per Damkier, Hanne Rolighed Christensen, Ylva Böttiger, Jan Schjøtt
PURPOSE: The aim of this study was to identify structure and language elements affecting the quality of responses from Scandinavian drug information centres (DICs). METHODS: Six different fictitious drug-related queries were sent to each of seven Scandinavian DICs. The centres were blinded for which queries were part of the study. The responses were assessed qualitatively by six clinical pharmacologists (internal experts) and six general practitioners (GPs, external experts)...
February 5, 2017: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28151991/clinical-impact-of-pharmacogenetic-profiling-with-a-clinical-decision-support-tool-in-polypharmacy-home-health-patients-a-prospective-pilot-randomized-controlled-trial
#5
Lindsay S Elliott, John C Henderson, Moni B Neradilek, Nicolas A Moyer, Kristine C Ashcraft, Ranjit K Thirumaran
BACKGROUND: In polypharmacy patients under home health management, pharmacogenetic testing coupled with guidance from a clinical decision support tool (CDST) on reducing drug, gene, and cumulative interaction risk may provide valuable insights in prescription drug treatment, reducing re-hospitalization and emergency department (ED) visits. We assessed the clinical impact of pharmacogenetic profiling integrating binary and cumulative drug and gene interaction warnings on home health polypharmacy patients...
2017: PloS One
https://www.readbyqxmd.com/read/28139458/completeness-accuracy-and-readability-of-wikipedia-as-a-reference-for-patient-medication-information
#6
Danielle M Candelario, Victoria Vazquez, William Jackson, Timothy Reilly
OBJECTIVES: This study determined the completeness, accuracy, and reading level of Wikipedia patient drug information compared with the corresponding United States product insert medication guides. METHODS: From the Top 200 Drugs of 2012, the top 33 medications with medication guides were analyzed. Medication guides and Wikipedia pages were downloaded on a single date to ensure continuity of Wikipedia content. To quantify the completeness and accuracy of the Wikipedia medication information, a scoring system was adapted from previously published work and compared with the 7 core domains of medication guides...
January 28, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28111172/self-medication-and-self-prescription-with-antibiotics-in-the-middle-east-do-they-really-happen-a-systematic-review-of-the-prevalence-possible-reasons-and-outcomes
#7
REVIEW
Faten Alhomoud, Zainab Aljamea, Reem Almahasnah, Khawlah Alkhalifah, Lama Basalelah, Farah Kais Alhomoud
OBJECTIVES: There has been no review on the prevalence, possible causes, and clinical outcomes of self-medication with antibiotics (SMA) in the Middle East. METHODS: Databases were searched (January 2000 through June 2016) for articles on SMA among adults aged ≥18 years living in the Middle East. A hand search for relevant citations and key journals was also performed. RESULTS: Twenty-two studies were found. The prevalence of SMA ranged from 19% to 82%...
January 19, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28108896/pharmacophore-based-screening-and-drug-repurposing-exemplified-on-glycogen-synthase-kinase-3-inhibitors
#8
Luminita Crisan, Sorin Avram, Liliana Pacureanu
The current study was conducted to elaborate a novel pharmacophore model to accurately map selective glycogen synthase kinase-3 (GSK-3) inhibitors, and perform virtual screening and drug repurposing. Pharmacophore modeling was developed using PHASE on a data set of 203 maleimides. Two benchmarking validation data sets with focus on selectivity were assembled using ChEMBL and PubChem GSK-3 confirmatory assays. A drug repurposing experiment linking pharmacophore matching with drug information originating from multiple data sources was performed...
January 21, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28097713/pharmacist-industry-relationships
#9
Keene Saavedra, Bonnie O'Connor, Adriane Fugh-Berman
OBJECTIVES: The purpose of this study was to document, in their own words, beliefs and attitudes that American pharmacists have towards the pharmaceutical industry and pharmacists' interactions with industry. METHODS: An ethnographic-style qualitative study was conducted utilizing open-ended interviews with four hospital pharmacists, two independent pharmacists, two retail pharmacists and one administrative pharmacist in the Washington, DC, metropolitan area to elicit descriptions of and attitudes towards pharmacists' relationships with industry...
January 18, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28080146/perceptions-vs-evidence-therapeutic-substitutes-for-antipsychotics-in-patients-with-dementia-in-long-term-care
#10
Brianne L Olivieri-Mui, John W Devlin, Aileen Ochoa, Danielle Schenck, Becky Briesacher
OBJECTIVE: To compare differences between clinician perceptions of therapeutic substitutes for antipsychotics prescribed to patients with dementia in long term care (LTC) and published evidence. METHODS: A mixed-methods approach that included a drug information search, online survey of 55 LTC clinicians and a comprehensive literature review was used. For 41 pharmacologic antipsychotic substitute candidates identified, LTC clinicians rated the likelihood they would substitute each for patients with dementia and identified non-pharmacologic antipsychotic substitutes...
January 12, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28073580/drug-information-by-public-health-and-regulatory-institutions-results-of-an-8-country-survey-in-europe
#11
Giulio Formoso, Maria Font-Pous, Wolf-Dieter Ludwig, David Phizackerley, Dick Bijl, Juan Erviti, Blanka Pospíšilová, Jean Louis Montastruc
PURPOSE: To evaluate the framework of drug information produced by public health and regulatory institutions in Europe. MATERIALS AND METHODS: We carried out a short survey asking editors of ISDB bulletins of the European region to indicate the main sources of drug information provided by public health and regulatory authorities in their countries, the specific kind of information produced and their opinions about strengths and weaknesses of such information. The availability of evaluations about the added therapeutic value of drugs and of tools facilitating the implementation of such information were particularly addressed and checked on the websites of those institutions...
December 29, 2016: Health Policy
https://www.readbyqxmd.com/read/28060329/drug-repurposing-hypothesis-generation-using-the-re-fine-drugs-system
#12
Kelly Regan, Soheil Moosavinasab, Philip Payne, Simon Lin
The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates...
December 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28049901/improvement-of-clinical-skills-through-pharmaceutical-education-and-clinical-research
#13
Junko Ishizaki
 Professors and teaching staff in the field of pharmaceutical sciences should devote themselves to staying abreast of relevant education and research. Similarly those in clinical pharmacies should contribute to the advancement of pharmaceutical research and the development of next generation pharmacists and pharmaceuticals. It is thought that those who work in clinical pharmacies should improve their own skills and expertise in problem-finding and -solving, i.e., "clinical skills". They should be keen to learn new standard treatments based on the latest drug information, and should try to be in a position where collecting clinical information is readily possible...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28045654/information-systems-in-clinical-pharmacy-applied-to-parenteral-nutrition-management-and-traceability-a-systematic-review
#14
Josefa Martínez Gabarrón, Javier Sanz-Valero, Carmina Wanden-Berghe
OBJECTIVE: To review the scientific literature on clinical pharmacy information systems applied to parenteral nutrition (PN) management and traceability. METHOD: A systematic review of the documents retrieved from the MEDLINE (PubMed), Web of Science, Scopus, Cochrane Library, International Pharmaceutical Abstracts (IPA) and Google Scholar databases up to May, 2016. The terms used, as descriptors and free text, were: "Parenteral Nutrition" and "Drug Information Services"...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28043712/pharmaceutical-pictograms-for-low-literate-patients-understanding-risk-of-false-confidence-and-evidence-based-design-strategies
#15
Mara M van Beusekom, Anne M Land-Zandstra, Mark J W Bos, Jos M van den Broek, Henk-Jan Guchelaar
OBJECTIVE: This study aims to (1) evaluate ten pharmaceutical pictograms for low-literate patients on understandability, (2) assess the risk of false confidence in understanding, and (3) identify how the design can be improved to increase understandability. METHODS: Interviews were conducted with n=197 pharmacy visitors in the Netherlands. Additional qualitative discussions were held with n=30 adequately and n=25 low-literate participants (assessed with REALM-D)...
December 19, 2016: Patient Education and Counseling
https://www.readbyqxmd.com/read/28042673/using-incident-reports-to-inform-the-prevention-of-medication-administration-errors
#16
Marja Härkänen, Susanna Saano, Katri Vehviläinen-Julkunen
AIMS AND OBJECTIVES: The aim of this study is to describe ways of preventing medication administration errors based on reporters' views expressed in medication administration incident reports. BACKGROUND: Medication administration errors are very common, and nurses play important roles in committing and in preventing such errors. Thus far, incident reporters' perceptions of how to prevent medication administration errors have rarely been analysed. DESIGN AND METHODS: This is a qualitative, descriptive study using an inductive content analysis of the incident reports related to medication administration errors (n=1012)...
January 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28042169/the-problem-of-polypharmacy-in-female-patients-with-overactive-bladders-cross-sectional-study-in-a-specialist-outpatient-department
#17
C S Schneidinger, W Umek, B Böhmdorfer
Background: The consumption of certain drugs can cause urinary incontinence. The aim of this study is to determine the frequency of consumption of drugs that can favour incontinence, the incidence of polypharmacy and the incidence of potentially dangerous drug-drug interactions in female patients suffering from overactive bladder (OAB) who presented to a urogynaecological outpatient department. Methods: We undertook a retrospective case series study. The data from 100 female patients who attended the urogynaecological outpatient department of the Vienna General Hospital [VGH; Allgemeinen Krankenhauses Wien (AKH)] in the period from 20...
December 2016: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28033282/evaluation-of-counseling-environmental-alteration-on-pharmacy-patient-communication-qualifications-a-case-control-study
#18
Hongyan Gu, Lulu Sun, Rui Jin, Fang Li, Yuanyuan Wei, Zhengzheng Xie
The closed pharmaceutical counseling room was so hard to be established for most of hospitals in China since limited space in the out-patient lobby, which dramatically affected the qualification of medication consultant. Few reports studied the importance of closed pharmaceutical counseling room construction.To investigate the necessary of closed pharmaceutical counseling room construction in the outpatient lobby.The closed pharmaceutical counseling room was established and equipped with hospital electronic information system, patient education flashes, and we-Chat in web...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28028268/-consideration-of-the-work-content-of-the-clinic-pharmacist-and-its-usefulness
#19
Hirofumi Imajo, Kazutaka Imai, Kazuhiro Hisajima, Masato Kishimoto, Kyosuke Sekiya, Yoshihiko Kagawa, Honami Talman-Teramoto, Yukihiro Soga, Keigo Yasukawa, Masayoshi Hirohara, Kazuki Kushida
"Medical teams"have been promoted in the home care setting. For the pharmacist, it is possible to maintain the safety and improve the quality of medical care by working with a multidisciplinary team. The arrangement of the pharmacist with the clinic is specified in Article 18 of the Medical Care Law, but there is no medical treatment fee for the clinic pharmacist. We examined the work content and usefulness of the clinic pharmacist. The work content was to participate in visiting consultation, introduce pharmacotherapy management based on the clinic pharmacist's working protocol, propose prescriptions, provide drug information service, and cooperate with insurance pharmacy pharmacists...
December 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28013365/how-can-we-define-and-analyse-drug-exposure-more-precisely-to-improve-the-prediction-of-hospitalizations-in-longitudinal-claims-data
#20
Andreas D Meid, Andreas Groll, Ulrich Schieborr, Jochen Walker, Walter E Haefeli
BACKGROUND: Risk prediction models can be powerful tools to support clinical decision-making, to help targeting interventions, and, thus, to improve clinical and economic outcomes, provided that model performance is good and sensitivity and specificity are well balanced. Drug utilization as a potential risk factor for unplanned hospitalizations has recently emerged as a meaningful predictor variable in such models. Drug treatment is a rather unstable (i.e. time-dependent) phenomenon and most drug-induced events are concentration-dependent and therefore individual drug exposure will likely modulate the risk...
December 24, 2016: European Journal of Clinical Pharmacology
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