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https://www.readbyqxmd.com/read/29753117/pharmacological-inhibition-of-receptor-protein-tyrosine-phosphatase-%C3%AE-%C3%AE-ptprz1-modulates-behavioral-responses-to-ethanol
#1
Rosalía Fernández-Calle, Marta Vicente-Rodríguez, Miryam Pastor, Esther Gramage, Bruno Di Geronimo, José María Zapico, Claire Coderch, Carmen Pérez-García, Amy W Lasek, Beatriz de Pascual-Teresa, Ana Ramos, Gonzalo Herradón
Pleiotrophin (PTN) and Midkine (MK) are neurotrophic factors that are upregulated in the prefrontal cortex after alcohol administration and have been shown to reduce ethanol drinking and reward. PTN and MK are the endogenous inhibitors of Receptor Protein Tyrosine Phosphatase (RPTP) β/ζ (a.k.a. PTPRZ1, RPTPβ, PTPζ), suggesting a potential role for this phosphatase in the regulation of alcohol effects. To determine if RPTPβ/ζ regulates ethanol consumption, we treated mice with recently developed small-molecule inhibitors of RPTPβ/ζ (MY10, MY33-3) before testing them for binge-like drinking using the drinking in the dark protocol...
May 9, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29731691/analysis-of-selected-pro-and-anti-inflammatory-cytokines-in-patients-with-multiple-injuries-in-the-early-period-after-trauma
#2
Katarzyna Gołąbek-Dropiewska, Justyna Pawłowska, Jacek Witkowski, Jerzy Lasek, Wojciech Marks, Mariusz Stasiak, Dawid Jaskólski, Aleksandra Kawecka, Piotr Łuczkiewicz, Bogusław Baczkowski
Introduction: Severe trauma causes damage to the protective barriers of the organism, and thus activates immunological reaction. Among substances secreted during this process pro-inflammatory cytokines are of high importance. The aim of the study: Severe trauma causing multiple injuries is more likely to lead to particularly intensive inflammatory reaction, which can sometimes lead to serious complications, even life-threatening. The aim of the study is to determine those parameters which may serve as predictors of infectious complications and to enable estimation of the patient's immunological status before the decision to introduce elective procedures...
2018: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29609111/regulation-of-anxiety-like-behavior-and-crhr1-expression-in-the-basolateral-amygdala-by-lmo3
#3
Antonia Savarese, Amy W Lasek
The LIM domain only protein LMO3 is a transcriptional regulator that has been shown to regulate several behavioral responses to alcohol. Specifically, Lmo3 null (Lmo3Z ) mice consume more ethanol in a binge-drinking test and show enhanced ethanol-induced sedation. Due to the high comorbidity of alcohol use and anxiety, we investigated anxiety-like behavior in Lmo3Z mice. Lmo3Z mice spent more time in the open arms of the elevated plus maze compared with their wild-type littermates, but the effect was confounded by reduced locomotor activity...
March 27, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29594350/transcriptional-regulators-as-targets-for-alcohol-pharmacotherapies
#4
Antonia M Savarese, Amy W Lasek
Alcohol use disorder (AUD) is a chronic relapsing brain disease that currently afflicts over 15 million adults in the United States. Despite its prevalence, there are only three FDA-approved medications for AUD treatment, all of which show limited efficacy. Because of their ability to alter expression of a large number of genes, often with great cell-type and brain-region specificity, transcription factors and epigenetic modifiers serve as promising new targets for the development of AUD treatments aimed at the neural circuitry that underlies chronic alcohol abuse...
March 29, 2018: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/29587253/early-and-one-year-outcomes-of-acute-stroke-in-the-industrial-region-of-poland-during-the-decade-2006-2015-the-silesian-stroke-registry
#5
Marek Gierlotka, Beata Labuz-Roszak, Bogdan Wojtyniak, Anetta Lasek-Bal, Tomasz Zdrojewski, Monika Adamczyk-Sowa, Kamil Chwojnicki, Michal Skrzypek, Daniel Ciesla, Mariusz Gasior
BACKGROUND: Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. METHODS: Silesian Stroke Registry was created from the administrative database of the public, obligatory, health -insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006-2015 (n = 120,844)...
March 27, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29577820/risk-factor-profile-in-patients-with-stroke-at-a-young-age
#6
Anetta Lasek-Bal, Ilona Kopyta, Aldona Warsz-Wianecka, Przemysław Puz, Beata Łabuz-Roszak, Katarzyna Zaręba
Background The distribution of risk factors for stroke is related to gender and age. The main objective of study was to determine the type and frequency of stroke risk factors in patients with first-in-life stroke before the age of 50. Methods Our study included patients under the age of 50 with first-in-life stroke. The following data obtained from all participants were analyzed: a neuroimaging of the head, wide panel of blood tests, electrocardiogram, transesophageal echocardiography, ultrasound of the carotid/cerebral arteries...
March 26, 2018: Neurological Research
https://www.readbyqxmd.com/read/29561408/keratectasia-after-laser-assisted-subepithelial-keratectomy-for-myopia-a-case-report
#7
Qinghong Lin, Lin Zheng, Xiumei Lin, Qian Wang
RATIONALE: Recently, some ophthalmologists performed PRK or LASEK surgeries in FFKC suspicious patients, which is supposed to prevent FFKC evolvement via fibrotic scar formation. Our report indicates that keratectasia can occur after LASEK in FFKC suspicious patients, highlighting the importance of stricter regulation of patient recruitment before the procedure and postoperative follow-up. PATIENT CONCERNS: This is a report of a 25-year-old man with poor corrected distance visual acuity (CDVA) 6 years after LASEK...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29533827/callitriche-cophocarpa-biomass-as-a-potential-low-cost-biosorbent-for-trivalent-chromium
#8
Joanna Kyzioł-Komosińska, Joanna Augustynowicz, Wojciech Lasek, Justyna Czupioł, Daniel Ociński
The present study focused on the use of the dry mass of the macrophyte Callitriche cophocarpa as an effective biosorbent for chromium removal from concentrated solutions, typical for industrial effluents. In order to evaluate the usability of C. cophocarpa as the Cr(III) sorbent, its detailed physicochemical characterization has been performed as well as the preliminary adsorption studies. The biosorbent was characterized by specific surface area (SSA), porosity, total organic carbon (TOC), inorganic content as well as the cation exchange capacity (CEC), dominant exchangeable cations and anion exchange capacity (AEC), point of zero charge (pHpzc ) and buffering capacity...
March 10, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29481990/20-years-experience-with-laparoscopic-splenectomy-single-center-outcomes-of-a-cohort-study-of-500-cases
#9
Dorota Radkowiak, Anna Zychowicz, Anna Lasek, Michał Wysocki, Piotr Major, Michał Pędziwiatr, Piotr Budzyński, Jan Kulawik, Andrzej Budzyński
BACKGROUND: Laparoscopic splenectomy (LS) has become the gold standard in elective spleen surgery. Although it is considered relatively safe, treatment results vary depending on a hospital's profile and the experience of the surgeon and center. We would like to present experience of a high-volume referral center with minimally invasive operations of the spleen. MATERIAL AND METHODS: The retrospective cohort study included consecutive patients undergoing laparoscopic splenectomy in tertiary referral surgical center in 1998-2017...
April 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29459257/effect-of-comorbidities-on-the-course-of-multiple-sclerosis
#10
Przemyslaw Puz, Anetta Lasek-Bal, Arkadiusz Steposz, Karina Bartoszek, Patrycja Radecka
OBJECTIVE: The clinical condition of multiple sclerosis (MS) patients depends not only on the course of MS but also on their lifestyle and comorbidities. This study aimed to assess the effect of selected comorbidities, lifestyle-related factors and clinical data available at the time of MS diagnosis, on the disease activity and the disability progression in patients with relapsing-remitting multiple sclerosis (RRMS). PATIENTS AND METHODS: Based on clinical relapses over a period of 12 months of observation and the results of MRI scans, 138 patients with RRMS were qualified into two groups: 'active' or 'stable' course of the disease...
April 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29436692/synergistic-antitumor-effects-of-histone-deacetylase-inhibitor-scriptaid-and-bortezomib-against-ovarian-cancer-cells
#11
Karolina Janyst, Michał Janyst, Marta Siernicka, Witold Lasek
Despite debulking surgery and good initial response to chemotherapy, the majority of patients with advanced ovarian cancer relapse and succumb to their disease. Thus, there is a pressing need to improve treatment outcome. In the present study, the antitumor activity of histone deacetylase (HDAC) inhibitor scriptaid in combination with bortezomib or conventional chemotherapeutics was tested in vitro against representative ovarian cancer cell lines: SKOV‑3, MDAH 2774, and OVP‑10. Incubation of ovarian cancer cells with scriptaid and bortezomib (or doxorubicin) led to synergistic antitumor effects...
April 2018: Oncology Reports
https://www.readbyqxmd.com/read/29329693/bold-fmri-signal-in-stroke-patients-and-its-importance-for-prognosis-in-the-subacute-disease-period-preliminary-report
#12
Anetta Lasek-Bal, Joanna Kidoń, Monika Błaszczyszyn, Bartłomiej Stasiów, Amadeusz Żak
Functional magnetic resonance imaging (fMRI) allows for the assessment of neuronal activity through the blood-level-dependent signal. The purpose of study was to evaluate the pattern of brain activity in fMRI in patients with ischemic stroke and to assess the potential relationship between the activity pattern and the neurological/functional status. METHODS: The fMRI was performed in patients up to 4th day of stroke. All the patients were analyzed according to NIHSS on 1st day and mRankin scale on 14th day of stroke, followed by analyzing of fMRI signal...
December 24, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29305887/estradiol-enhances-ethanol-reward-in-female-mice-through-activation-of-er%C3%AE-and-er%C3%AE
#13
Elisa R Hilderbrand, Amy W Lasek
Alcohol use disorder (AUD) manifests differently in men and women, but little is known about sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β-estradiol (E2) regulates voluntary ethanol consumption in female rodents. However, the role of E2 as a regulator of ethanol reward has not been investigated. In this study, we tested for the effects of E2 and agonists selective for the classical estrogen receptors, ERα and ERβ, on ethanol reward in ovariectomized (OVX) mice using the conditioned place preference (CPP) test...
February 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29296643/successful-combined-antibiotic-therapy-with-oral-clindamycin-and-oral-rifampicin-for-pyoderma-gangrenosum-in-patient-with-pash-syndrome
#14
Marie Lamiaux, Fadia Dabouz, Maud Wantz, Damien Lebas, Audrey Lasek, Domitille Courivaud, Philippe Modiano
No abstract text is available yet for this article.
January 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29289347/releasing-addiction-memories-trapped-in-perineuronal-nets
#15
REVIEW
Amy W Lasek, Hu Chen, Wei-Yang Chen
Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse. Recently, perineuronal nets (PNNs), extracellular matrix (ECM) structures surrounding neurons, have emerged as regulators of learning, memory, and addiction behaviors. PNNs do not merely provide structural support to neurons but are dynamically remodeled in an experience-dependent manner by metalloproteinases...
March 2018: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29275231/development-of-inhibitors-of-receptor-protein-tyrosine-phosphatase-%C3%AE-%C3%AE-ptprz1-as-candidates-for-cns-disorders
#16
Miryam Pastor, Rosalía Fernández-Calle, Bruno Di Geronimo, Marta Vicente-Rodríguez, José María Zapico, Esther Gramage, Claire Coderch, Carmen Pérez-García, Amy W Lasek, Leonor Puchades-Carrasco, Antonio Pineda-Lucena, Beatriz de Pascual-Teresa, Gonzalo Herradón, Ana Ramos
A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhibiting its tyrosine phosphatase activity. The most potent compounds 10a and 12b (IC50  = 0,1 μM) significantly increase the phosphorylation of key tyrosine residues of PTPRZ1 substrates involved in neuronal survival and differentiation, and display protective effects against amphetamine-induced toxicity...
January 20, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29238181/the-link-between-weight-shift-asymmetry-and-gait-disturbances-in-chronic-hemiparetic-stroke-patients
#17
Andrzej Szopa, Małgorzata Domagalska-Szopa, Anetta Lasek-Bal, Amadeusz Żak
Introduction: While the asymmetry of body posture and the asymmetrical nature of hemiparetic gait in poststroke (PS) patients are well documented, the role of weight shift asymmetry in gait disorders after stroke remains unclear. Objective: We examined the association of weight-bearing asymmetry (WBA) between paretic and nonparetic lower limbs during quiet standing with the degree of deviation of hemiplegic gait from normal gait evaluated by the Gillette Gait Index (GGI) incorporating 16 distinct clinically important kinematic and temporal parameters in chronic PS patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29227676/studying-sex-differences-in-animal-models-of-addiction-an-emphasis-on-alcohol-related-behaviors
#18
Elisa R Hilderbrand, Amy W Lasek
Animal models are essential for understanding the biological factors that contribute to drug and alcohol addiction and discovering new pharmacotherapies to treat these disorders. Alcohol (ethanol) is the most commonly abused drug in the world, and as the prevalence of alcohol use disorder (AUD) increases, so does the need for effective pharmacotherapies. In particular, treatments with high efficacy in the growing number of female AUD sufferers are needed. Female animals remain underrepresented in biomedical research and sex differences in the brain's response to alcohol are poorly understood...
December 26, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29227509/long-term-follow-up-of-lasek-with-mitomycin-c-performed-to-correct-myopia-in-thin-corneas
#19
Montserrat Garcia-Gonzalez, Pilar Drake Rodriguez-Casanova, Isabel Rodriguez-Perez, Alberto Rodero, Miguel A Teus
PURPOSE: To evaluate the long-term outcomes of laser-assisted subepithelial keratomileusis (LASEK) with intraoperative use of mitomycin C (MMC) performed on thin corneas for the correction of myopia. METHODS: This retrospective cohort study included 100 eyes with a preoperative central corneal thickness (CCT) thinner than 500 μm that underwent LASEK + MMC with at least 6 years of follow-up. Stability of visual acuity and refraction and the efficacy, safety, and predictability at the examinations 3 months and the last annual postoperative visit were analyzed...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29221869/characteristics-of-hospitalizations-due-to-acute-stroke-in-the-silesian-province-poland-between-2009-and-2015
#20
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Anetta Lasek-Bal, Mariusz Gąsior, Marek Gierlotka
INTRODUCTION: The available data on acute stroke (AS) in Poland come mainly from non-representative cohorts or are outdated. Therefore, the current study was done to access the most recent data on AS in the industrial region that covers 12% (4.6mln) of the country's population. OBJECTIVE: To evaluate the epidemiological data of AS in the Silesian Province, Poland. PATIENTS AND METHODS: Analysis of the data from stroke questionnaires, obligatory for all patients hospitalized due to AS and administered by the only public health insurer in Poland (the National Health Fund) between 2009 and 2015 (n=81,193)...
November 27, 2017: Neurologia i Neurochirurgia Polska
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