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https://www.readbyqxmd.com/read/28411109/letter-to-the-editor-concerning-hajdu-cheney-syndrome-report-of-a-novel-notch2-mutation-and-treatment-with-denosumab-by-g-adami-et-al-bone-2016-92-150-156
#1
https://www.readbyqxmd.com/read/28398003/midkine-in-the-mouse-ventral-tegmental-area-limits-ethanol-intake-and-ccl2-gene-expression
#2
Hu Chen, Donghong He, Amy W Lasek
Midkine (MDK) is a cytokine and neurotrophic factor that is more highly expressed in the brains of human alcoholics and in mice predisposed to drink large amounts of ethanol, suggesting that MDK may regulate ethanol consumption. Here we measured ethanol consumption in male and female Mdk knockout (-/-) mice using the two-bottle choice and the drinking in the dark (DID) tests. We found that Mdk -/- mice consumed significantly more ethanol than wild type controls in both tests. To determine if MDK acts in the ventral tegmental area (VTA) to regulate ethanol consumption, we delivered lentivirus expressing a Mdk shRNA into the VTA of male C57BL/6J mice to locally knockdown Mdk and performed the DID test...
April 11, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28380698/myoclonus-epilepsy-and-ataxia-due-to-kcnc1-mutation-analysis-of-20-cases-and-k-channel-properties
#3
Karen L Oliver, Silvana Franceschetti, Carol J Milligan, Mikko Muona, Simone A Mandelstam, Laura Canafoglia, Anna M Boguszewska-Chachulska, Amos Korczyn, Francesca Bisulli, Carlo Di Bonaventura, Francesca Ragona, Roberto Michelucci, Bruria Ben-Zeev, Rachel Straussberg, Ferruccio Panzica, João Massano, Daniel Friedman, Arielle Crespel, Bernt A Engelsen, Frederick Andermann, Eva Andermann, Krystyna Spodar, Anetta Lasek-Bal, Patrizia Riguzzi, Elena Pasini, Paolo Tinuper, Laura Licchetta, Elena Gardella, Matthias Lindenau, Annette Wulf, Rikke S Møller, Felix Benninger, Zaid Afawi, Guido Rubboli, Christopher A Reid, Snezana Maljevic, Holger Lerche, Anna-Elina Lehesjoki, Steven Petrou, Samuel F Berkovic
OBJECTIVE: To comprehensively describe the new syndrome of myoclonus epilepsy and ataxia due to potassium (K(+) ) channel mutation (MEAK), including cellular electrophysiological characterization of observed clinical improvement with fever. METHODS: We analysed clinical, electroclinical and neuroimaging data for twenty patients with MEAK due to recurrent KCNC1 p.R320H mutation. In vitro electrophysiological studies were conducted using whole cell patch clamp to explore biophysical properties of wild-type and mutant KV 3...
April 5, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28336402/post-operative-efficacy-predictability-safety-and-visual-quality-of-laser-corneal-refractive-surgery-a-network-meta-analysis
#4
Daizong Wen, Colm McAlinden, Ian Flitcroft, Ruixue Tu, Qinmei Wang, Jorge Alió, John Marshall, Yingying Huang, Benhao Song, Liang Hu, Yune Zhao, Senmiao Zhu, Rongrong Gao, Fangjun Bao, Ayong Yu, Ye Yu, Hengli Lian, Jinhai Huang
PURPOSE: To compare the post-operative efficacy, predictability, safety and visual quality of all major forms of laser corneal refractive surgeries for correcting myopia. DESIGN: Systematic review and network meta-analysis. METHODS: MEDLINE, EMBASE, Cochrane Library and the US trial registry was conducted up to November 2015. Randomized controlled trials (RCT) reporting in accordance with the eligibility criteria were included in this review...
March 20, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28285388/effect-of-iris-registration-on-visual-outcome-in-wavefront-guided-lasek-for-myopic-astigmatism
#5
Jong Joo Lee, Mee Kum Kim, Won Ryang Wee
PURPOSE: This study aimed to investigate the effect of iris registration (IR) on visual outcomes in wavefront-guided LASEK for myopic astigmatism. METHODS: The retrospective chart review was performed for wavefront-guided LASEK using VISX Star S4 in patients with myopic astigmatism (cylinder ≥ 1.00 diopter[D]). Eyes were divided into IR group (LASEK with IR at the time of surgery) and Non-IR group (LASEK without IR system + failed-IR engagement during LASEK)...
March 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28243192/the-sodium-channel-%C3%AE-4-auxiliary-subunit-selectively-controls-long-term-depression-in-core-nucleus-accumbens-medium-spiny-neurons
#6
Xincai Ji, Sucharita Saha, Guangping Gao, Amy W Lasek, Gregg E Homanics, Melissa Guildford, Andrew R Tapper, Gilles E Martin
Voltage-gated sodium channels are essential for generating the initial rapid depolarization of neuronal membrane potential during action potentials (APs) that enable cell-to-cell communication, the propagation of signals throughout the brain, and the induction of synaptic plasticity. Although all brain neurons express one or several variants coding for the core pore-forming sodium channel α subunit, the expression of the β (β1-4) auxiliary subunits varies greatly. Of particular interest is the β4 subunit, encoded by the Scn4b gene, that is highly expressed in dorsal and ventral (i...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28197998/laser-assisted-subepithelial-keratectomy-lasek-versus-laser-assisted-in-situ-keratomileusis-lasik-for-correcting-myopia
#7
REVIEW
Jocelyn Kuryan, Anjum Cheema, Roy S Chuck
BACKGROUND: Near-sightedness, or myopia, is a condition in which light rays entering the eye along the visual axis focus in front of the retina, resulting in blurred vision. Myopia can be treated with spectacles, contact lenses, or refractive surgery. Options for refractive surgery include laser-assisted subepithelial keratectomy (LASEK) and laser-assisted in-situ keratomileusis (LASIK). Both procedures utilize a laser to shape the corneal tissue (front of the eye) to correct refractive error, and both create flaps before laser treatment of corneal stromal tissue...
February 15, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28135746/-smile-re-treatment-options-techniques-and-results
#8
B Meyer, K S Kunert
With a rate of less than 2 %, retreatment after SMILE is rare. If a touch-up is required, there are different options to choose from: surface ablation (PRK/LASEK) with Mitomycin C, the standard femto-flap procedure with the same parameters, the CIRCLE procedure, which extends the previous SMILE interface into a flap, or the innovative but off-label capless SMILE procedure, which preserves all the advantages of SMILE.
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28040705/notch2-genetic-mutation-and-acro-osteolysis-the-hajdu-cheney-syndrome
#9
G Jerzakowski, T Lasek, A Binkiewicz-Glinska, M Krygier, P Zawadzki
No abstract text is available yet for this article.
February 1, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28011949/the-presence-of-tau-protein-in-blood-as-a-potential-prognostic-factor-in-stroke-patients
#10
A A Lasek-Bal, H Jedrzejowska-Szypulka, J Rozycka, W Bal, A Kowalczyk, M Holecki, J Dulawa, J Lewin-Kowalik
Tau protein is found in the blood of 40 - 50% of patients in the acute phase of a stroke, as a result of the degradation of neurons and damage to the blood-brain barrier. The aim of the study was to assess the incidence of tau protein in the blood of stroke patients, as well as to evaluate the potential impact of tau protein presence in the blood of patients on their neurological state during the first 24 hours, and their functional condition three months after the stroke. Eighty-seven patients aged 39 - 99 (42 females and 45 males) diagnosed with stroke were enrolled in the prospective study (August 2014 - April 2015)...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/27986929/genetic-and-pharmacologic-manipulation-of-tlr4-has-minimal-impact-on-ethanol-consumption-in-rodents
#11
R Adron Harris, Michal Bajo, Richard L Bell, Yuri A Blednov, Florence P Varodayan, Jay M Truitt, Giordano de Guglielmo, Amy W Lasek, Marian L Logrip, Leandro F Vendruscolo, Amanda J Roberts, Edward Roberts, Olivier George, Jody Mayfield, Timothy R Billiar, David J Hackam, R Dayne Mayfield, George F Koob, Marisa Roberto, Gregg E Homanics
Toll-like receptor 4 (TLR4) is a critical component of innate immune signaling and has been implicated in alcohol responses in preclinical and clinical models. Members of the Integrative Neuroscience Initiative on Alcoholism (INIA-Neuroimmune) consortium tested the hypothesis that TLR4 mediates excessive ethanol drinking using the following models: (1) Tlr4 knock-out (KO) rats, (2) selective knockdown of Tlr4 mRNA in mouse nucleus accumbens (NAc), and (3) injection of the TLR4 antagonist (+)-naloxone in mice...
February 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27919195/efficacy-and-safety-of-mitoxantrone-use-in-primary-and-secondary-progressive-multiple-sclerosis-study-site-experience-based-on-the-therapy-of-104-patients
#12
Anetta Lasek-Bal, Karina Bartoszek, Arkadiusz Steposz, Przemyslaw Puz, Wieslaw Bal, Zofia Kazibutowska
Mitoxantrone (MX) is used in patients with primary and secondary progressive as well as relapsing-remitting type of multiple sclerosis (PPMS, SPMS, RRMS). The objective of our project was to evaluate the efficacy and safety of MX use in patients with PPMS and SPMS. METHODS: The retrospective study included 104 patients (mean age 54.2 ± 9.0), with PPMS (13.46%) and SPMS (86.54%) treated with MX. During single cycle of the MX therapy a dose of 12 mg/m(2) of body surface area was administered and next cycles every three months up to a total dose of 140 mg/m(2) were realized...
December 23, 2016: International Journal of Neuroscience
https://www.readbyqxmd.com/read/27903932/laparoscopic-approach-to-splenic-aneurysms
#13
Piotr Małczak, Michał Wysocki, Piotr Major, Michał Pędziwiatr, Anna Lasek, Tomasz Stefura, Dorota Radkowiak, Anna Zub-Pokrowiecka, Andrzej Budzyński
Background Splenic artery aneurysm is a rare disease with possibly mortal complications. For years, the main method of treatment was excision of aneurysm with spleen. In recent years, several methods have been developed in order to salvage the spleen such endovascular techniques and aneurysmectomy. Objective The aim of our study was to determine the feasibility of laparoscopic aneurysmectomy with spleen salvage in cases of splenic artery aneurysm. Materials Analysis of prospectively gathered data containing records of patients operated laparoscopically due to diseases of the spleen in 1998-2016 in our department...
January 1, 2016: Vascular
https://www.readbyqxmd.com/read/27893524/visual-outcomes-after-smile-lasek-and-lasek-combined-with-corneal-collagen-cross-linking-for-high-myopic-correction
#14
Sangyoon Hyun, Seongjun Lee, Jae-Hyung Kim
PURPOSE: To compare the visual and refractive outcomes of small-incision lenticule extraction (SMILE), laser-assisted subepithelial keratomileusis (LASEK), and LASEK combined with corneal collagen cross-linking (LASEK-CXL) surgery for high-degree myopia. METHODS: Medical records of patients with spherical equivalent (SE) greater than -6.00 diopters (D) treated with SMILE, LASEK, and LASEK-CXL were reviewed. Uncorrected distance visual acuity (UCVA), SE, and corneal haze were followed up in the 3 groups for 6 months...
April 2017: Cornea
https://www.readbyqxmd.com/read/27865199/cha2ds2-vasc-af2-score-accurately-predicts-moderate-to-severe-acute-neurological-dysfunction-in-the-course-of-first-ever-ischaemic-stroke
#15
Maciej T Wybraniec, Maciej Faryan, Błażej Kusz, Anetta Lasek-Bal, Katarzyna Mizia-Stec
No abstract text is available yet for this article.
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27853351/the-effect-of-humidity-and-temperature-on-visual-outcomes-after-myopic-corneal-laser-refractive-surgery
#16
Christopher T Hood, Roni M Shtein, Daniel Veldheer, Munira Hussain, Leslie M Niziol, David C Musch, Shahzad I Mian
OBJECTIVE: To determine whether procedure room environmental conditions are associated with outcomes after myopic laser in situ keratomileusis (LASIK) or laser-assisted keratomileusis (LASEK). DESIGN: Retrospective chart review. PARTICIPANTS: Eight hundred sixty-three eyes of 458 consecutive patients at a university-based academic practice. METHODS: We reviewed the medical records of consecutive patients who underwent LASIK or LASEK over a 3-year period...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/27845775/defining-the-role-of-corticotropin-releasing-factor-binding-protein-in-alcohol-consumption
#17
C L Haass-Koffler, A T Henry, G Melkus, J A Simms, M Naemmuddin, C K Nielsen, A W Lasek, M Magill, M L Schwandt, R Momenan, C A Hodgkinson, S E Bartlett, R M Swift, A Bonci, L Leggio
The corticotropin releasing factor (CRF) exerts its effects by acting on its receptors and on the binding protein (CRFBP), and has been implicated in alcohol use disorder (AUD). Therefore, identification of the exact contribution of each protein that mediates CRF effects is necessary to design effective therapeutic strategies for AUD. A series of in vitro/in vivo experiments across different species were performed to define the biological discrete role of CRFBP in AUD. First, to establish the CRFBP role in receptor signaling, we developed a novel chimeric cell-based assay and showed that CFRBP full length can stably be expressed on the plasma membrane...
November 15, 2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27829656/safety-and-efficacy-of-fingolimod-and-natalizumab-in-multiple-sclerosis-after-the-failure-of-first-line-therapy-single-center-experience-based-on-the-treatment-of-forty-four-patients
#18
Przemysław Puz, Anetta Lasek-Bal
BACKGROUND In Poland, natalizumab or fingolimod treatment can be delivered as a second-line therapy to those patients with relapsing-remitting multiple sclerosis (RRMS) who demonstrated no response to interferon or glatiramer acetate treatment for a minimum of one year. MATERIAL AND METHODS Analysis covered 44 RRMS patients switched from first- to second-line therapy. The annualized relapse rate, disability progression (assessed with Expanded Disability Status Scale, EDSS) and MRI results (new or enlarged T2 lesions and new Gd-positive lesions) before and after switching were compared...
November 10, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27822501/inhibition-of-ikk%C3%AE-reduces-ethanol-consumption-in-c57bl-6j-mice
#19
Jay M Truitt, Yuri A Blednov, Jillian M Benavidez, Mendy Black, Olga Ponomareva, Jade Law, Morgan Merriman, Sami Horani, Kelly Jameson, Amy W Lasek, R Adron Harris, R Dayne Mayfield
Proinflammatory pathways in neuronal and non-neuronal cells are implicated in the acute and chronic effects of alcohol exposure in animal models and humans. The nuclear factor-κB (NF-κB) family of DNA transcription factors plays important roles in inflammatory diseases. The kinase IKKβ mediates the phosphorylation and subsequent proteasomal degradation of cytosolic protein inhibitors of NF-κB, leading to activation of NF-κB. The role of IKKβ as a potential regulator of excessive alcohol drinking had not previously been investigated...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27751694/femtosecond-laser-assisted-sub-bowman-keratomileusis-versus-laser-assisted-subepithelial-keratomileusis-to-correct-myopic-astigmatism
#20
Juan Gros-Otero, Montserrat Garcia-Gonzalez, Miguel A Teus, MariLuz Iglesias-Iglesias, Carlos Gimenez-Vallejo
PURPOSE: To compare femtosecond laser-assisted sub-Bowman keratomileusis (FSBK) versus laser-assisted subepithelial keratomileusis (LASEK) to correct moderate to high myopic astigmatism. METHODS: Retrospective, nonrandomized, interventional, comparative case series. A total of eight hundred and fifty-two eyes with myopic astigmatism of -1.5 diopters (D) or higher were included in the study. We compared 427 eyes treated with FSBK versus 425 eyes treated with LASEK with or without mitomycin C...
October 13, 2016: Journal of Optometry
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