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https://www.readbyqxmd.com/read/29329693/bold-fmri-signal-in-stroke-patients-and-its-importance-for-prognosis-in-the-subacute-disease-period-preliminary-report
#1
Anetta Lasek-Bal, Joanna Kidoń, Monika Błaszczyszyn, Bartłomiej Stasiów, Amadeusz Żak
Functional magnetic resonance imaging (fMRI) allows for the assessment of neuronal activity through the blood-level-dependent signal. The purpose of study was to evaluate the pattern of brain activity in fMRI in patients with ischemic stroke and to assess the potential relationship between the activity pattern and the neurological/functional status. METHODS: The fMRI was performed in patients up to 4th day of stroke. All the patients were analyzed according to NIHSS on 1st day and mRankin scale on 14th day of stroke, followed by analyzing of fMRI signal...
December 24, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29305887/estradiol-enhances-ethanol-reward-in-female-mice-through-activation-of-er%C3%AE-and-er%C3%AE
#2
Elisa R Hilderbrand, Amy W Lasek
Alcohol use disorder (AUD) manifests differently in men and women, but little is known about sex differences in the brain's response to ethanol. It is known that the steroid hormone 17β-estradiol (E2) regulates voluntary ethanol consumption in female rodents. However, the role of E2 as a regulator of ethanol reward has not been investigated. In this study, we tested for the effects of E2 and agonists selective for the classical estrogen receptors, ERα and ERβ, on ethanol reward in ovariectomized (OVX) mice using the conditioned place preference (CPP) test...
January 3, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29296643/successful-combined-antibiotic-therapy-with-oral-clindamycin-and-oral-rifampicin-for-pyoderma-gangrenosum-in-patient-with-pash-syndrome
#3
Marie Lamiaux, Fadia Dabouz, Maud Wantz, Damien Lebas, Audrey Lasek, Domitille Courivaud, Philippe Modiano
No abstract text is available yet for this article.
January 2018: JAAD Case Reports
https://www.readbyqxmd.com/read/29289347/releasing-addiction-memories-trapped-in-perineuronal-nets
#4
REVIEW
Amy W Lasek, Hu Chen, Wei-Yang Chen
Drug addiction can be conceptualized at a basic level as maladaptive learning and memory. Addictive substances elicit changes in brain circuitry involved in reward, cognition, and emotional state, leading to the formation and persistence of strong drug-associated memories that lead to craving and relapse. Recently, perineuronal nets (PNNs), extracellular matrix (ECM) structures surrounding neurons, have emerged as regulators of learning, memory, and addiction behaviors. PNNs do not merely provide structural support to neurons but are dynamically remodeled in an experience-dependent manner by metalloproteinases...
December 27, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/29275231/development-of-inhibitors-of-receptor-protein-tyrosine-phosphatase-%C3%AE-%C3%AE-ptprz1-as-candidates-for-cns-disorders
#5
Miryam Pastor, Rosalía Fernández-Calle, Bruno Di Geronimo, Marta Vicente-Rodríguez, José María Zapico, Esther Gramage, Claire Coderch, Carmen Pérez-García, Amy W Lasek, Leonor Puchades-Carrasco, Antonio Pineda-Lucena, Beatriz de Pascual-Teresa, Gonzalo Herradón, Ana Ramos
A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhibiting its tyrosine phosphatase activity. The most potent compounds 10a and 12b (IC50 = 0,1 μM) significantly increase the phosphorylation of key tyrosine residues of PTPRZ1 substrates involved in neuronal survival and differentiation, and display protective effects against amphetamine-induced toxicity...
November 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29238181/the-link-between-weight-shift-asymmetry-and-gait-disturbances-in-chronic-hemiparetic-stroke-patients
#6
Andrzej Szopa, Małgorzata Domagalska-Szopa, Anetta Lasek-Bal, Amadeusz Żak
Introduction: While the asymmetry of body posture and the asymmetrical nature of hemiparetic gait in poststroke (PS) patients are well documented, the role of weight shift asymmetry in gait disorders after stroke remains unclear. Objective: We examined the association of weight-bearing asymmetry (WBA) between paretic and nonparetic lower limbs during quiet standing with the degree of deviation of hemiplegic gait from normal gait evaluated by the Gillette Gait Index (GGI) incorporating 16 distinct clinically important kinematic and temporal parameters in chronic PS patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29227676/studying-sex-differences-in-animal-models-of-addiction-an-emphasis-on-alcohol-related-behaviors
#7
Elisa R Hilderbrand, Amy W Lasek
Animal models are essential for understanding the biological factors that contribute to drug and alcohol addiction and discovering new pharmacotherapies to treat these disorders. Alcohol (ethanol) is the most commonly abused drug in the world, and as the prevalence of alcohol use disorder (AUD) increases, so does the need for effective pharmacotherapies. In particular, treatments with high efficacy in the growing number of female AUD sufferers are needed. Female animals remain underrepresented in biomedical research and sex differences in the brain's response to alcohol are poorly understood...
December 11, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/29227509/long-term-follow-up-of-lasek-with-mitomycin-c-performed-to-correct-myopia-in-thin-corneas
#8
Montserrat Garcia-Gonzalez, Pilar Drake Rodriguez-Casanova, Isabel Rodriguez-Perez, Alberto Rodero, Miguel A Teus
PURPOSE: To evaluate the long-term outcomes of laser-assisted subepithelial keratomileusis (LASEK) with intraoperative use of mitomycin C (MMC) performed on thin corneas for the correction of myopia. METHODS: This retrospective cohort study included 100 eyes with a preoperative central corneal thickness (CCT) thinner than 500 μm that underwent LASEK + MMC with at least 6 years of follow-up. Stability of visual acuity and refraction and the efficacy, safety, and predictability at the examinations 3 months and the last annual postoperative visit were analyzed...
December 1, 2017: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29221869/characteristics-of-hospitalizations-due-to-acute-stroke-in-the-silesian-province-poland-between-2009-and-2015
#9
Anna Starostka-Tatar, Beata Łabuz-Roszak, Michał Skrzypek, Anetta Lasek-Bal, Mariusz Gąsior, Marek Gierlotka
INTRODUCTION: The available data on acute stroke (AS) in Poland come mainly from non-representative cohorts or are outdated. Therefore, the current study was done to access the most recent data on AS in the industrial region that covers 12% (4.6mln) of the country's population. OBJECTIVE: To evaluate the epidemiological data of AS in the Silesian Province, Poland. PATIENTS AND METHODS: Analysis of the data from stroke questionnaires, obligatory for all patients hospitalized due to AS and administered by the only public health insurer in Poland (the National Health Fund) between 2009 and 2015 (n=81,193)...
November 27, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29210827/demarcation-line-in-the-human-cornea-after-surface-ablation-observed-by-optical-coherence-tomography-and-confocal-microscopy
#10
Meiyan Li, Yu Zhao, Qirui Xiao, Peijun Yao, Mingzi Piao, Ling Sun, Xingtao Zhou
PURPOSE: To investigate the long-term changes in anterior corneal structure after surface ablation. METHODS: In this retrospective study, patients who received surface ablation including laser-assisted subepithelial keratomileusis (LASEK) and epipolis laser in situ keratomileusis at the Department of Ophthalmology of Fudan University Eye and Ear, Nose and Throat (EENT) Hospital (Shanghai, People's Republic of China) were telephoned. Patients were asked to follow-up at the refractive center...
November 28, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/29205408/ovarian-hormones-contribute-to-high-levels-of-binge-like-drinking-by-female-mice
#11
Rosalba Satta, Elisa R Hilderbrand, Amy W Lasek
BACKGROUND: Recently, the incidence of binge drinking by women has increased. Binge drinking is detrimental to women's health, yet the biological mechanisms that promote excessive drinking by women are not well understood. One method of assessing binge-like ethanol (EtOH) consumption in mice is the drinking in the dark (DID) test, in which mice drink sufficient EtOH to achieve intoxication. In this study, we directly compared male, female, and ovariectomized (OVX) mice for DID and tested whether 17β-estradiol (E2) contributes to DID...
December 5, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29198761/diagnostics-treatment-and-secondary-prevention-of-ischemic-stroke-in-the-silesian-province-poland-between-2009-and-2015
#12
Beata Łabuz-Roszak, Anna Starostka-Tatar, Anetta Lasek-Bal, Marek Gierlotka, Mariusz Gąsior, Michał Skrzypek
BACKGROUND: The available data on diagnostics and treatment of ischemic stroke (IS) in Poland come mainly from non-representative cohorts or are outdated. OBJECTIVE: Therefore, the current study was done to access the most recent data on IS in the industrial region that covers 12% of the country's population. MATERIALS & METHODS: Analysis of the data from stroke questionnaires, obligatory for all patients hospitalized due to acute stroke and administered by the National Health Fund (the only public health insurer in Poland) between 2009 and 2015 (n=81,193)...
November 14, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29168666/diagnostic-methods-used-in-searching-for-markers-of-atrophy-in-patients-with-multiple-sclerosis
#13
Przemyslaw Puz, Arkadiusz Steposz, Anetta Lasek-Bal, Karina Bartoszek, Patrycja Radecka, Aleksandra Karuga-Pierścieńska
The results of available studies on assessment of neurodegenerative lesions in multiple sclerosis (MS) patients using different approaches have not been conclusive. Currently, clinical assessment is the most commonly used (involving primarily mobility assessment), along with magnetic resonance imaging and electrophysiological testing. In this review we describe available clinical, neuroimaging, electrophysiological and laboratory tests used to assess the neurodegeneration in MS. Laboratory markers to determine the risk of disease, its conversion and prognosis in MS patients are being constantly sought...
November 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/29107956/estradiol-increases-the-sensitivity-of-ventral-tegmental-area-dopamine-neurons-to-dopamine-and-ethanol
#14
Bertha J Vandegrift, Chang You, Rosalba Satta, Mark S Brodie, Amy W Lasek
Gender differences in psychiatric disorders such as addiction may be modulated by the steroid hormone estrogen. For instance, 17β-estradiol (E2), the predominant form of circulating estrogen in pre-menopausal females, increases ethanol consumption, suggesting that E2 may affect the rewarding properties of ethanol and thus the development of alcohol use disorder in females. The ventral tegmental area (VTA) is critically involved in the rewarding and reinforcing effects of ethanol. In order to determine the role of E2 in VTA physiology, gonadally intact female mice were sacrificed during diestrus II (high E2) or estrus (low E2) for electrophysiology recordings...
2017: PloS One
https://www.readbyqxmd.com/read/29032414/influence-of-lasek-on-schi%C3%A3-tz-goldmann-and-dynamic-contour-tonometry
#15
Marco Sales-Sanz, Esther Arranz-Marquez, Carolina Arruabarrena, Miguel A Teus
PURPOSE: Our purpose was to assess the effect of LASEK surgery on ocular rigidity and to compare its effect on intraocular pressure (IOP) readings with Goldmann applanation tonometry (GAT), Schiøtz indentation tonometry (ST) and dynamic contour tonometry (DCT). METHODS: Prospective, observational, single-masked cohort study. One eye per patient from 31 consecutive subjects who underwent LASEK refractive surgery to correct myopia, as well as from 108 non-operated myopic patients, were included...
October 14, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28985990/the-importance-of-atrial-fibrillation-and-selected-echocardiographic-parameters-for-the-effectiveness-and-safety-of-thrombolytic-therapy-in-patients-with-stroke
#16
Lasek-Bal Anetta, Kowalewska-Twardela Teresa, Warsz-Wianecka Aldona, Puz Przemysław, Krzan Aleksandra, Cieślik Aleksandra
BACKGROUND: The efficacy and safety of thrombolytic therapy in stroke depend on multiple factors. The aim of this study was to evaluate the significance of atrial fibrillation the prognosis in terms of the functional status in patients with stroke treated with intravenous thrombolysis. An additional aim was also to assess the potential significance of reduced ejection fraction (EF) and enlarged left atrium (LA) of the heart for the prognosis in patients with stroke who underwent thrombolytic therapy...
September 19, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28943471/childhood-chronic-prurigo-interest-in-patch-tests-and-delayed-reading-skin-prick-tests-to-environmental-allergens
#17
Claire Maridet, Martin Perromat, Juliette Miquel, Christine Chiaverini, Didier Bessis, Audrey Lasek, Maryam Piram, Anne-Claire Bursztejn, Claire Abasq, Alice Phan, Ludovic Martin, Bérénice Bréchat, Jin Ho Chong, Julien Seneschal, Alain Taïeb, Franck Boralevi
No abstract text is available yet for this article.
September 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28919459/genome-content-metabolic-pathways-and-biotechnological-potential-of-the-psychrophilic-arctic-bacterium-psychrobacter-sp-dab_al43b-a-source-and-a-host-of-novel-psychrobacter-specific-vectors
#18
Robert Lasek, Lukasz Dziewit, Anna Ciok, Przemyslaw Decewicz, Krzysztof Romaniuk, Zuzanna Jedrys, Daniel Wibberg, Andreas Schlüter, Alfred Pühler, Dariusz Bartosik
Psychrobacter sp. DAB_AL43B, isolated from ornithogenic soil collected on the Arctic island of Spitsbergen, is a newly sequenced psychrophilic strain susceptible to conjugation and electrotransformation. Its genome consists of a circular chromosome (3.3 Mb) and four plasmids (4.4-6.4kb). In silico genome mining and microarray-based phenotypic analysis were performed to describe the metabolic potential of this strain and identify possible biotechnological applications. Metabolic reconstruction indicated that DAB_AL43B prefers low-molecular-weight carboxylates and amino acids as carbon and energy sources...
September 15, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28860990/anaplastic-lymphoma-kinase-is-a-regulator-of-alcohol-consumption-and-excitatory-synaptic-plasticity-in-the-nucleus-accumbens-shell
#19
Regina A Mangieri, Esther Y Maier, Tavanna R Buske, Amy W Lasek, Richard A Morrisett
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), and putative targets for treating AUD may be validated for further development by assessing how their manipulation modulates accumbal glutamatergic synaptic transmission and plasticity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28858384/reduced-levels-of-mglu2-receptors-within-the-prelimbic-cortex-are-not-associated-with-elevated-glutamate-transmission-or-high-alcohol-drinking
#20
Zheng-Ming Ding, Cynthia M Ingraham, Sheketha R Hauser, Amy W Lasek, Richard L Bell, William J McBride
BACKGROUND: A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol-preferring (P) rats. The objectives of the current study were to characterize the effects of reduced levels of mGlu2 receptors on glutamate transmission and alcohol drinking. METHODS: Quantitative no-net-flux microdialysis was used to test the hypothesis that basal extracellular glutamate levels in the prelimbic (PL) cortex and nucleus accumbens shell (NACsh) will be higher in P than Wistar rats...
November 2017: Alcoholism, Clinical and Experimental Research
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