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https://www.readbyqxmd.com/read/28919459/genome-content-metabolic-pathways-and-biotechnological-potential-of-the-psychrophilic-arctic-bacterium-psychrobacter-sp-dab_al43b-a-source-and-a-host-of-novel-psychrobacter-specific-vectors
#1
Robert Lasek, Lukasz Dziewit, Anna Ciok, Przemyslaw Decewicz, Krzysztof Romaniuk, Zuzanna Jedrys, Daniel Wibberg, Andreas Schlüter, Alfred Pühler, Dariusz Bartosik
Psychrobacter sp. DAB_AL43B, isolated from ornithogenic soil collected on the Arctic island of Spitsbergen, is a newly sequenced psychrophilic strain susceptible to conjugation and electrotransformation. Its genome consists of a circular chromosome (3.3 Mb) and four plasmids (4.4-6.4kb). In silico genome mining and microarray-based phenotypic analysis were performed to describe the metabolic potential of this strain and identify possible biotechnological applications. Metabolic reconstruction indicated that DAB_AL43B prefers low-molecular-weight carboxylates and amino acids as carbon and energy sources...
September 14, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28860990/anaplastic-lymphoma-kinase-is-a-regulator-of-alcohol-consumption-and-excitatory-synaptic-plasticity-in-the-nucleus-accumbens-shell
#2
Regina A Mangieri, Esther Y Maier, Tavanna R Buske, Amy W Lasek, Richard A Morrisett
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase recently implicated in biochemical, physiological, and behavioral responses to ethanol. Thus, manipulation of ALK signaling may represent a novel approach to treating alcohol use disorder (AUD). Ethanol induces adaptations in glutamatergic synapses onto nucleus accumbens shell (NAcSh) medium spiny neurons (MSNs), and putative targets for treating AUD may be validated for further development by assessing how their manipulation modulates accumbal glutamatergic synaptic transmission and plasticity...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28858384/reduced-levels-of-mglu2-receptors-within-the-prelimbic-cortex-not-associated-with-elevated-glutamate-transmission-or-high-alcohol-drinking
#3
Zheng-Ming Ding, Cynthia M Ingraham, Sheketha R Hauser, Amy W Lasek, Richard L Bell, William J McBride
BACKGROUND: A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being associated with high alcohol drinking by alcohol preferring (P) rats. The objectives of the current study were to characterize the effects of reduced levels of mGlu2 receptors on glutamate transmission and alcohol drinking. METHODS: Quantitative no-net-flux microdialysis was used to test the hypothesis that basal extracellular glutamate levels in the prelimbic (PL) cortex and nucleus accumbens shell (NACsh) will be higher in P than Wistar rats...
August 31, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28837530/visual-outcomes-after-smile-lasek-and-lasek-combined-with-corneal-cross-linking-for-high-myopic-correction
#4
Montserrat Garcia-Gonzalez, Miguel A Teus, Juan Gros-Otero
No abstract text is available yet for this article.
August 23, 2017: Cornea
https://www.readbyqxmd.com/read/28771544/comparison-of-postoperative-visual-quality-after-smile-and-lasek-for-high-myopia-a-1-year-outcome
#5
Xiaoyu Zhu, Leilei Zou, Manrong Yu, Chen Qiu, Minjie Chen, Jinhui Dai
PURPOSE: To compare the 1-year outcome of visual quality after laser-assisted subepithelial keratomileusis (LASEK) and femtosecond laser-assisted small incision lenticule extraction (SMILE) for high myopia correction. MATERIALS AND METHODS: This prospective, comparative study included 24 eyes of 24 patients in the LASEK group, with a mean spherical equivalent (SE) of -7.59 ± 1.32 diopters, and 26 eyes of 26 patients in the SMILE group, with a mean SE of -7.91 ± 1...
2017: PloS One
https://www.readbyqxmd.com/read/28756015/mechanical-thrombectomy-in-acute-stroke-five-years-of-experience-in-poland
#6
Agnieszka Słowik, Marcin Wnuk, Paweł Brzegowy, Joanna Chrzanowska-Waśko, Aleksandra Golenia, Bartłomiej Łasocha, Dorota Włoch-Kopeć, Antoni Ferens, Wojciech Serednicki, Piotr Jarocki, Halina Bartosik-Psujek, Rafał Kaczorowski, Edward Filip, Monika Grzegorzak, Jarosław Homa, Janusz Darocha, Daniel Dudek, Wiesław Guz, Konrad Rejdak, Piotr Luchowski, Joanna Wojczal, Michał Sojka, Michał Górnik, Sylwia Stachowicz, Jacek Jaworski, Kinga Buraczyńska, Remigiusz Ficek, Anna Szczepańska-Szerej, Tomasz Jargiełło, Małgorzata Szczerbo-Trojanowska, Anetta Lasek-Bal, Przemysław Puz, Aldona Warsz-Wianecka, Arkadiusz Stęposz, Krzysztof Ziaja, Wacław Kuczmik, Tomasz Urbanek, Damian Ziaja, Witold Tomalski, Adam Kobayashi, Przemysław Richter, Andrzej Płoński, Marcin Kotkowski, Wojciech Czepiel, Iwona Kurkowska-Jastrzębska, Halina Sienkiewicz-Jarosz, Anna Członkowska, Beata BłażejewskaHyżorek, Danuta Ryglewicz, Magdalena Konopko, Edyta Brelak, Jacek Antecki, Igor Szydłowski, Maciej Włosek, Adam Stępień, Krzysztof Brzozowski, Jacek Staszewski, Piotr Piasecki, Piotr Zięcina, Izabela Wołoszyńska, Norbert Kolmaga, Jerzy Narloch, Tomasz Hasiec, Jacek Gawłowicz, Monika Pędracka, Jacek Porębiak, Bogumił Grzechnik, Vadym Matsibora, Michał Frąszczak, Marcin Leus, Maciej Mazgaj, Violetta Palacz-Duda, Grzegorz Meder, Wojciech Skura, Piotr Płeszka, Milena Świtońska, Krzysztof Słomiński, Józef Kościelniak, Paulina Sobieszak-Skura, Magdalena Konieczna-Brazis, Olgierd Rowiński, Andrzej Opuchlik, Anatol Mickielewicz, Beata Szyluk, Piotr Szczudlik, Anna Kostera-Pruszczyk, Maciej Jaworski, Rafał Maciąg, Jarosław Żyłkowski, Bożena Adamkiewicz, Wojciech Szubert, Jarosław Chrząstek, Marek Raźniewski, Agnieszka Pawelec, Paweł Wilimborek, Ryszard Wagner, Paweł Pilarski, Paweł Gierach, Jan Baron, Wojciech Gruszka, Stanisław Ochudło, Agnieszka Krzak-Kubica, Monika Rudzińska-Bar, Miłosz Zbroszczyk, Kamila Smulska, Michał Arkuszewski, Dorota Różański, Dariusz Koziorowski, Izabela Meisner-Kramarz, Stanisław Szlufik, Artur Zaczyński, Krzysztof Kądziołka, Kazimierz Kordecki, Michał Zawadzki, Mirosław Ząbek, Bartosz Karaszewski, Dariusz Gąsecki, Paweł Łowiec, Waldemar Dorniak, Tomasz Gorycki, Edyta Szurowska, Ewa Wierzchowska-Cioch, Tomasz Smyk, Beata Szajnoga, Marcin Bachta, Kajetan Mazurek, Magdalena Piwowarska, Wojciech Kociemba, Artur Drużdż, Adrian Dąbrowski, Michał Glonek, Małgorzata Wawrzyniak, Radosław Kaźmierski, Robert Juszkat, Witold Tomalski, Adam Heliosz, Adam Ryszczyk, Jacek Zwiernik, Grzegorz Wasilewski, Andrzej Tutaj, Grzegorz Dałek, Krzysztof Nosek, Sławomir Bereza, Katarzyna Lubkowska, Jerzy Kamienowski, Piotr Sobolewski, Adam Bielecki, Maciej Miś, Marcin Miś, Maria Krużewska-Orłowska, Jan Kochanowicz, Zenon Mariak, Marta Jakoniuk, Grzegorz Turek, Urszula Łebkowska, Andrzej Lewszuk, Kazimierz Kordecki, Tomasz Dziedzic, Tadeusz Popiela
OBJECTIVES: Mechanical thrombectomy (MT) is not reimbursed by the Polish public health system. We present a description of 5 years of experience with MT in acute stroke in Comprehensive Stroke Centers (CSCs) in Poland. METHODS AND RESULTS: We retrospectively analyzed the results of a structured questionnaire from 23 out of 25 identified CSCs and 22 data sets that include 61 clinical, radiological and outcome measures. RESULTS: Most of the CSCs (74%) were founded at University Hospitals and most (65...
July 5, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/28727129/potentialization-of-n-a-tosyl-l-phenylalanine-chloromethyl-ketone-tpck-cytotoxic-activity-by-2-1-adamantylamino-6-methylpyridine-adamp-in-human-ovarian-cancer-cells
#7
Jacek Sieńko, Witold Lasek, Justyna Teliga-Czajkowska, Roman Smolarczyk, Krzysztof Czajkowski
OBJECTIVES: TNF is one of the key cytokines involved in cancer development. TNF signaling can result in both stimulating and inhibitory signals that can result in opposite biological effects in cancerogenesis. 2-(1-adamantylamino)-6-methylpyridine (AdAMP) enhances TNF secretion whereas N-a-tosyl-L-phenylalanine chloromethyl ketone (TPCK) is a NF-κB inhibitor potentially stimulating proapoptotic TNF signals. The aim of the study was to assess the effect of TPCK in combination with AdAMP on human ovarian cells...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28645265/a-pilot-study-lasek-with-the-triple-a-profile-of-a-mel-90-for-mild-and-moderate-myopia
#8
Yingjun Chen, Dong Yang, Tian Han, Haipeng Xu, Meiyan Li, Xingtao Zhou
BACKGROUND: To investigate the visual and refractive outcomes in patients with mild to moderate myopia after laser-assisted subepithelial keratectomy (LASEK) using the 500 Hz pulse rate of the Triple-A profile. METHODS: Thirty-six eyes of 20 patients (mean age, 27.5 ± 4.6 years) were included in this prospective, consecutive study. Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), corneal topography, and corneal aberrations were measured preoperatively and 1 day, 1 week, 1, 3 and 6 months post-operation...
June 23, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28623743/repeated-measurements-of-serum-concentrations-of-tnf-alpha-interleukin-6-and-interleukin-10-in-the-evaluation-of-internal-carotid-artery-stenosis-progression
#9
Przemyslaw Puz, Anetta Lasek-Bal
BACKGROUND AND AIMS: The inflammatory process (with TNFα, interleukin-6 and interleukin-10 involvement) plays a key role in the development, progression and destabilization of atherosclerotic plaques. The aim of this study was to assess the importance of double-checked measurements of TNFα, interleukin-6 (IL-6) and interleukin-10 (Il-10) serum levels in patients with internal carotid artery (ICA) stenosis to determine the dynamics of changes in the stenosis degree and in the ultrasound plaque morphology...
June 3, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28606616/the-effect-of-previous-soft-contact-lens-wear-on-corneal-refractive-surgery-outcomes
#10
Aoife Lloyd-McKernan, Luisa Simo Mannion, Veronica O'Dwyer
PURPOSE: To examine the influence of previous soft contact lens (SCL) wear on corneal refractive surgery (CRS) outcomes when SCL wear is ceased for two weeks versus twenty-four hours, and also when compared to no wear, prior to CRS. METHODS: A retrospective examination of CRS patient records was carried out for two groups of patients- who ceased SCL wear for two weeks (n=45) and for twenty-four hours (n=49) prior to CRS and compared to a non-contact lens (NCL) control group (n=45 and n=49, respectively)...
October 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28562575/predictability-and-stability-of-laser-assisted-subepithelial-keratectomy-with-mitomycin-c-for-the-correction-of-high-myopia
#11
COMPARATIVE STUDY
Lawrence P L Iu, Michelle C Y Fan, Ivan N Chen, Jimmy S M Lai
The purpose of this study was to evaluate the predictability and stability of laser-assisted subepithelial keratectomy (LASEK) with mitomycin C (MMC) in correction of high myopia (≤-6.0 diopters [D]) as compared to low-to-moderate myopia (>-6.0 D).This is a retrospective, comparative, cohort study which included 43 eyes of 43 consecutive patients who underwent LASEK with MMC in a private hospital in Hong Kong by a single surgeon. Twenty-five eyes had high myopia (mean spherical equivalent [SE] = -8.53 ± 1...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28544605/assessment-of-meibomian-glands-and-tear-film-in-post-refractive-surgery-patients
#12
Ji Won Jung, Jung Yong Kim, Hee Seung Chin, Young Ju Suh, Tae-Im Kim, Kyoung Yul Seo
IMPORTANCE: Corneal refractive surgery may impact meibomian gland and tear film in post-refractive surgery patients. BACKGROUND: To compare ocular surface parameters between post-refractive surgery patients and normal controls. DESIGN: Cross-sectional single center study PARTICIPANTS: A total of 120 eyes of 120 subjects were divided into three groups: (i) 60 controls and 60 patients underwent corneal refractive surgery at least 12 months ago; (ii) 30 post-laser in-situ keratomileusis (LASIK) patients and (iii) 30 post-laser epithelial keratomileusis (LASEK)/photo-refractive keratectomy (PRK) patients...
May 22, 2017: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/28522788/effects-of-bariatric-surgery-on-cardiovascular-risk-factors-among-morbidly-obese-patients
#13
Piotr Major, Aleksandra Kowalczuk, Michał Wysocki, Sonia Osadnik, Michał Pędziwiatr, Anna Głuszewska, Magdalena Pisarska, Piotr Małczak, Anna Lasek, Michał Kisielewski, Andrzej Budzyński
AIM OF THE STUDY: The aim of this study was to evaluate the influence of laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric by-pass on risk factors of cardiovascular diseases. MATERIAL AND METHODS: We analyzed prospectively collected data of patients operated for morbid obesity who were qualified for laparoscopic sleeve gastrectomy (LSG) or laparoscopic Roux-en-Y gastric by-pass (LRYGB). Risk factors for wyłączecardiovascular diseases were assessed with the SCORE scale and both full and hard Framingham cardiovascular risk scores (FCRs)...
February 28, 2017: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/28411109/letter-to-the-editor-concerning-hajdu-cheney-syndrome-report-of-a-novel-notch2-mutation-and-treatment-with-denosumab-by-g-adami-et-al-bone-2016-92-150-156
#14
https://www.readbyqxmd.com/read/28398003/midkine-in-the-mouse-ventral-tegmental-area-limits-ethanol-intake-and-ccl2-gene-expression
#15
H Chen, D He, A W Lasek
Midkine (MDK) is a cytokine and neurotrophic factor that is more highly expressed in the brains of alcoholics and in mice predisposed to drink large amounts of ethanol, suggesting that MDK may regulate ethanol consumption. Here we measured ethanol consumption in male and female Mdk knockout (-/-) mice using the two-bottle choice and the drinking in the dark (DID) tests. We found that Mdk -/- mice consumed significantly more ethanol than wild-type controls in both tests. To determine if MDK acts in the ventral tegmental area (VTA) to regulate ethanol consumption, we delivered lentivirus expressing a Mdk shRNA into the VTA of male C57BL/6J mice to locally knockdown Mdk and performed the DID test...
September 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28380698/myoclonus-epilepsy-and-ataxia-due-to-kcnc1-mutation-analysis-of-20-cases-and-k-channel-properties
#16
Karen L Oliver, Silvana Franceschetti, Carol J Milligan, Mikko Muona, Simone A Mandelstam, Laura Canafoglia, Anna M Boguszewska-Chachulska, Amos D Korczyn, Francesca Bisulli, Carlo Di Bonaventura, Francesca Ragona, Roberto Michelucci, Bruria Ben-Zeev, Rachel Straussberg, Ferruccio Panzica, João Massano, Daniel Friedman, Arielle Crespel, Bernt A Engelsen, Frederick Andermann, Eva Andermann, Krystyna Spodar, Anetta Lasek-Bal, Patrizia Riguzzi, Elena Pasini, Paolo Tinuper, Laura Licchetta, Elena Gardella, Matthias Lindenau, Annette Wulf, Rikke S Møller, Felix Benninger, Zaid Afawi, Guido Rubboli, Christopher A Reid, Snezana Maljevic, Holger Lerche, Anna-Elina Lehesjoki, Steven Petrou, Samuel F Berkovic
OBJECTIVE: To comprehensively describe the new syndrome of myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK), including cellular electrophysiological characterization of observed clinical improvement with fever. METHODS: We analyzed clinical, electroclinical, and neuroimaging data for 20 patients with MEAK due to recurrent KCNC1 p.R320H mutation. In vitro electrophysiological studies were conducted using whole cell patch-clamp to explore biophysical properties of wild-type and mutant KV 3...
May 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28336402/postoperative-efficacy-predictability-safety-and-visual-quality-of-laser-corneal-refractive-surgery-a-network-meta-analysis
#17
REVIEW
Daizong Wen, Colm McAlinden, Ian Flitcroft, Ruixue Tu, Qinmei Wang, Jorge Alió, John Marshall, Yingying Huang, Benhao Song, Liang Hu, Yune Zhao, Senmiao Zhu, Rongrong Gao, Fangjun Bao, Ayong Yu, Ye Yu, Hengli Lian, Jinhai Huang
PURPOSE: To compare the postoperative efficacy, predictability, safety, and visual quality of all major forms of laser corneal refractive surgeries for correcting myopia. DESIGN: Systematic review and network meta-analysis. METHODS: Search of MEDLINE, EMBASE, Cochrane Library, and the US trial registry was conducted up to November 2015. Randomized controlled trials (RCT) reporting in accordance with the eligibility criteria were included in this review...
June 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28285388/effect-of-iris-registration-on-visual-outcome-in-wavefront-guided-lasek-for-myopic-astigmatism
#18
Jong Joo Lee, Mee Kum Kim, Won Ryang Wee
PURPOSE: This study aimed to investigate the effect of iris registration (IR) on visual outcomes in wavefront-guided LASEK for myopic astigmatism. METHODS: The retrospective chart review was performed for wavefront-guided LASEK using VISX Star S4 in patients with myopic astigmatism (cylinder ≥ 1.00 diopter[D]). Eyes were divided into IR group (LASEK with IR at the time of surgery) and Non-IR group (LASEK without IR system + failed-IR engagement during LASEK)...
March 11, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28243192/the-sodium-channel-%C3%AE-4-auxiliary-subunit-selectively-controls-long-term-depression-in-core-nucleus-accumbens-medium-spiny-neurons
#19
Xincai Ji, Sucharita Saha, Guangping Gao, Amy W Lasek, Gregg E Homanics, Melissa Guildford, Andrew R Tapper, Gilles E Martin
Voltage-gated sodium channels are essential for generating the initial rapid depolarization of neuronal membrane potential during action potentials (APs) that enable cell-to-cell communication, the propagation of signals throughout the brain, and the induction of synaptic plasticity. Although all brain neurons express one or several variants coding for the core pore-forming sodium channel α subunit, the expression of the β (β1-4) auxiliary subunits varies greatly. Of particular interest is the β4 subunit, encoded by the Scn4b gene, that is highly expressed in dorsal and ventral (i...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28197998/laser-assisted-subepithelial-keratectomy-lasek-versus-laser-assisted-in-situ-keratomileusis-lasik-for-correcting-myopia
#20
REVIEW
Jocelyn Kuryan, Anjum Cheema, Roy S Chuck
BACKGROUND: Near-sightedness, or myopia, is a condition in which light rays entering the eye along the visual axis focus in front of the retina, resulting in blurred vision. Myopia can be treated with spectacles, contact lenses, or refractive surgery. Options for refractive surgery include laser-assisted subepithelial keratectomy (LASEK) and laser-assisted in-situ keratomileusis (LASIK). Both procedures utilize a laser to shape the corneal tissue (front of the eye) to correct refractive error, and both create flaps before laser treatment of corneal stromal tissue...
February 15, 2017: Cochrane Database of Systematic Reviews
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