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https://www.readbyqxmd.com/read/29674324/indications-for-the-performance-of-intracranial-endovascular-neurointerventional-procedures-a-scientific-statement-from-the-american-heart-association
#1
REVIEW
Clifford J Eskey, Philip M Meyers, Thanh N Nguyen, Sameer A Ansari, Mahesh Jayaraman, Cameron G McDougall, J Kevin DeMarco, William A Gray, David C Hess, Randall T Higashida, Dilip K Pandey, Constantino Peña, Hermann C Schumacher
Intracranial endovascular interventions provide effective and minimally invasive treatment of a broad spectrum of diseases. This area of expertise has continued to gain both wider application and greater depth as new and better techniques are developed and as landmark clinical studies are performed to guide their use. Some of the greatest advances since the last American Heart Association scientific statement on this topic have been made in the treatment of ischemic stroke from large intracranial vessel occlusion, with more effective devices and large randomized clinical trials showing striking therapeutic benefit...
April 19, 2018: Circulation
https://www.readbyqxmd.com/read/29665749/early-and-mid-term-results-in-the-endovascular-treatment-of-popliteal-aneurysms-with-the-multilayer-flow-modulator
#2
Alessandro Ucci, Ruggiero Curci, Matteo Azzarone, Claudio Bianchini Massoni, Antonio Bozzani, Carla Marcato, Enrico Maria Marone, Paolo Perini, Tiziano Tecchio, Antonio Freyrie, Angelo Argenteri
Background The endovascular approach became an alternative to open surgical treatment of popliteal artery aneurysm over the last few years. Heparin-bonded stent-grafts have been employed for endovascular popliteal artery aneurysm repair, showing good and stable results. Only few reports about the use of multilayer flow modulator are available in literature, providing small patient series and short follow-up. The aim of this study is to report the outcomes of patients with popliteal artery aneurysm treated with the multilayer flow modulator in three Italian centres...
January 1, 2018: Vascular
https://www.readbyqxmd.com/read/29662195/ngr-asn-gly-arg-targeted-delivery-of-coagulase-to-tumor-vasculature-arrests-cancer-cell-growth
#3
Khaled Seidi, Rana Jahanban-Esfahlan, Hassan Monhemi, Peyman Zare, Babak Minofar, Amir Daei Farshchi Adli, Davoud Farajzadeh, Ramezan Behzadi, Mehran Mesgari Abbasi, Heidi A Neubauer, Richard Moriggl, Nosratollah Zarghami, Tahereh Javaheri
Induction of selective thrombosis and infarction in tumor-feeding vessels represents an attractive strategy to combat cancer. Here we took advantage of the unique coagulation properties of staphylocoagulase and genetically engineered it to generate a new fusion protein with novel anti-cancer properties. This novel bi-functional protein consists of truncated coagulase (tCoa) and an NGR (GNGRAHA) motif that recognizes CD13 and αv β3 integrin receptors, targeting it to tumor endothelial cells. Herein, we report that tCoa coupled by its C-terminus to an NGR sequence retained its normal binding activity with prothrombin and av β3 integrins, as confirmed in silico and in vitro...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29661597/clinical-performance-of-a-dedicated-self-apposing-stent-for-the-treatment-of-left-main-stem-disease-results-of-the-left-main-angioplasty-with-a-self-apposing-stent-the-matisse-study
#4
Bernardo Cortese, Antonio Montefusco, Fabrizio D'Ascenzo, Alessio La Manna, Giuseppe Andò, Teodoro Bisceglia, Gioel G Secco, Markus Meyer-Gessner, Wanha Wojciech, Paolo Sganzerla, Massimo Napodano, Gaetano Di Palma, Roberto A Latini, Corrado Tamburino, Pedro Silva Orrego, Andreas Baumbach
BACKGROUND: In the recent years percutaneous treatment of the left main stem (LM) has gained a precise role as a result of consistent scientific evidence vs. coronary artery bypass. A self-apposing stent offers an improved adaptation to the vessel wall, especially in case of tapered vessels; aim of this study was to investigate the role of a novel self-apposing, sirolimus-eluting stent (Stentys, France) for the treatment of LM coronary artery disease. METHODS AND RESULTS: MATISSE is a retrospective, multicenter registry, which enrolled 151 patients treated with the device at 17 international centers...
April 4, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29661534/a-new-chlorin-formulation-promotes-efficient-photodynamic-action-in-choriocapillaris-of-rabbit-s-eyes
#5
Gustavo H A Salomao, Adjaci U Fernandes, Mauricio S Baptista, João Paulo Tardivo, Stella Gianssante, Juliana Mora Veridiano, Olga Maria S Toledo, Giuliana Petri, Denise Maria Christofolini, João Antonio Correa
Age-related macular degeneration (AMD) as well as other choroidal diseases, demand novel therapeutic methods. Photodynamic therapy (PDT), which uses light and photosensitizer (PS) to cause specific vascular occlusion in the macula, is an interesting alternative. The only drug approved for the PDT treatment of AMD (Verteporfin) has a natural tendency to aggregate, demanding an expensive separation procedure during purification. We report a novel and affordable PS that is intrinsically protected against aggregation, the Monomeric Chlorin at High Concentration (MCHC-Chlorin), whose liposomal formulation was developed to provoke effective photodynamic action on the choroidal vasculature...
April 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29656433/antifibrinolytics-for-heavy-menstrual-bleeding
#6
REVIEW
Alison C Bryant-Smith, Anne Lethaby, Cindy Farquhar, Martha Hickey
BACKGROUND: Heavy menstrual bleeding (HMB) is an important physical and social problem for women. Oral treatment for HMB includes antifibrinolytic drugs, which are designed to reduce bleeding by inhibiting clot-dissolving enzymes in the endometrium.Historically, there has been some concern that using the antifibrinolytic tranexamic acid (TXA) for HMB may increase the risk of venous thromboembolic disease. This is an umbrella term for deep venous thrombosis (blood clots in the blood vessels in the legs) and pulmonary emboli (blood clots in the blood vessels in the lungs)...
April 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29656281/treatment-of-very-small-de-novo-coronary-artery-disease-with-2-0-mm-drug-coated-balloons-showed-1-year-clinical-outcome-comparable-with-2-0-mm-drug-eluting-stents
#7
Hui Wen Sim, Rajiv Ananthakrishna, Siew Pang Chan, Adrian F Low, Chi-Hang Lee, Mark Y Chan, Edgar L Tay, Poay Huan Loh, Koo Hui Chan, Huay Cheem Tan, Joshua P Loh
OBJECTIVE: To evaluate the 1-year clinical outcomes of patients treated with 2.0 mm drug-coated balloon (DCB) vs 2.0 mm drug-eluting stent (DES) implantation in small-caliber vessel de novo coronary artery disease (CAD). METHODS: All patients treated with 2.0 mm DCB or 2.0 mm DES for very small vessel de novo CAD from July 2014 to June 2016 were included in this study. The primary endpoint was the occurrence of target-lesion failure (TLF) and time to TLF, defined as a combination of cardiac mortality, target-vessel myocardial infarction, and target-lesion revascularization (TLR)...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29656279/drug-eluting-resorbable-magnesium-scaffold-implantation-in-st-segment-elevation-myocardial-infarction-a-pilot-study
#8
Quentin de Hemptinne, Fabien Picard, Rachid Briki, Ahmad Awada, Paul-Gaël Silance, Dariouch Dolatabadi, Nadia Debbas, Philippe Unger
OBJECTIVES: To assess feasibility and short-term clinical outcomes associated with resorbable magnesium scaffold (RMS) implantation in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). BACKGROUND: RMS implantation has demonstrated favorable clinical outcomes in stable coronary artery disease patients. However, to date, data are lacking in the setting of STEMI. METHODS: This is a single-center prospective non-randomized pilot study...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29627811/global-epidemiology-and-patterns-of-cerebral-venous-thrombosis-a-systematic-review-and-meta-analysis-protocol
#9
Celestin Danwang, Temgoua Ngou Mazou, Joël Noutakdie Tochie, Ronni Tankeu, Jean Joel Bigna
INTRODUCTION: Venous thrombosis can affect all veins in the body including cerebral veins, where it causes cerebral venous thrombosis (CVT). CVT is an aetiology of stroke, particularly in children and young adults. Its clinical features vary widely according to the occluded vessel. Data concerning the epidemiology of CVT are scant. This protocol for a systematic review and meta-analysis aims to critically synthesise data concerning prevalence, incidence, risk factors, anatomical patterns, diagnostic and therapeutic delays, and mortality rate of CVT in the global population...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29625391/imaging-thrombosis-with-99m-tc-labeled-ram-1-antibody-in-vivo
#10
Ali Ouadi, Virgile Bekaert, Nicolas Receveur, Lionel Thomas, François Lanza, Patrice Marchand, Christian Gachet, Pierre H Mangin, David Brasse, Patrice Laquerriere
INTRODUCTION: Platelets play a major role in thrombo-embolic diseases, notably by forming a thrombus that can ultimately occlude a vessel. This may provoke ischemic pathologies such as myocardial infarction, stroke or peripheral artery diseases, which represent the major causes of death worldwide. The aim of this study was to evaluate the specificity of radiolabeled Rat-Anti-Mouse antibody (RAM.1). METHODS: We describe a method to detect platelets by using a RAM...
March 17, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29624604/acute-myocardial-infarction-occurring-while-on-chronic-clopidogrel-therapy-clopidogrel-failure-is-associated-with-high-incidence-of-clopidogrel-poor-responsiveness-and-stent-thrombosis
#11
Ehud Regev, Elad Asher, Paul Fefer, Roy Beigel, Israel Mazin, Shlomi Matetzky
OBJECTIVES: The clinical significance of the laboratory-based phenomenon of clopidogrel hypo-responsiveness and platelet reactivity associated with acute myocardial infarction, despite chronic clopidogrel therapy, is largely unknown. We aimed to determine platelet reactivity and clinical and angiographic features in 29 consecutive patients sustaining an acute myocardial infarction despite chronic (≥1 month) clopidogrel therapy. METHODS: Platelet reactivity was determined on admission using conventional aggregometry...
2018: PloS One
https://www.readbyqxmd.com/read/29623171/bioresorbable-coronary-scaffolds-deployment-tips-and-tricks-and-the-future-of-the-technology
#12
REVIEW
J Ribamar Costa, Alexandre Abizaid
Bioresorbable scaffolds (BRS) were developed as an alternative to drug-eluting stents (DES) to facilitate vessel restoration and reduce the risk of future adverse events. However, recent meta-analyses and "real-world" registries have raised some concern about the safety of this novel technology, especially due to an increased risk of thrombosis within the first weeks of scaffold implantation. These devices appear to be less forgiving to poor implantation strategies when compared to contemporary DES...
January 2018: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29622141/clinical-angiographic-and-procedural-correlates-of-very-late-absorb-scaffold-thrombosis-multistudy-registry-results
#13
Stephen G Ellis, Tommaso Gori, Patrick W Serruys, Holger Nef, Giuseppe Steffenino, Salvatore Brugaletta, Thomas Munzel, Cordula Feliz, Götz Schmidt, Manel Sabaté, Yoshinobu Onuma, R J van Geuns, Run-Lin Gao, Maurizio Menichelli, Dean J Kereiakes, Gregg W Stone, Luca Testa, Takeshi Kimura, Alexandre Abizaid
OBJECTIVES: The aim of this study was to identify independent correlates of very late scaffold thrombosis (VLST) from an analysis of consecutively treated patients from 15 multicenter studies. BACKGROUND: Recent analyses suggest an increased risk for VLST with the Absorb Bioresorbable Vascular Scaffold compared with drug-eluting stents, but insights as to correlates of risk are limited. METHODS: A total of 55 patients were identified with scaffold thrombosis...
April 9, 2018: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29618068/occipital-artery-to-posterior-cerebral-artery-bypass-using-descending-branch-of-the-lateral-circumflex-femoral-artery-graft-for-treatment-of-fusiform-unruptured-posterior-cerebral-artery-aneurysm-3-dimensional-operative-video
#14
Kristine Ravina, Ian A Buchanan, Robert C Rennert, Ben A Strickland, Joseph N Carey, Jonathan J Russin
Posterior cerebral artery (PCA) aneurysms can be technically challenging lesions due to the intricacy of perforating branches and the relationship to cranial nerves and the brainstem. Fusiform aneurysms of the perimesencephalic segment of the PCA are a rare finding which does not favor direct clip occlusion or reconstruction. In such cases, proximal parent vessel occlusion is an option for aneurysm treatment. Extracranial-intracranial (EC-IC) bypass can be used to revascularize beyond the lesion when considering proximal occlusion...
April 3, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29611172/prevention-of-in-stent-restenosis-with-endothelial-progenitor-cell-epc-capture-stent-placement-combined-with-regional-epc-transplantation-an-atherosclerotic-rabbit-model
#15
You-Hua Huang, Qiang Xu, Tao Shen, Jian-Ke Li, Jing-Yu Sheng, Hong-Jian Shi
BACKGROUND: Even with drug-eluting stents, the risk of in-stent restenosis (ISR) remains high. The goal of this study was to investigate the use of an endothelial progenitor cell (EPC) capture stent plus regional EPC transplantation to reduce the ISR rate. METHODS: Endothelial progenitor cell capture stents were fabricated using fibrin gel and anti-CD34 plus anti-VEGFR-2 dual antibodies. Twenty male New Zealand white rabbits established as an atherosclerotic model were randomly divided into two groups: group 1 (n = 10), in which EPC capture stents were deployed into the right iliac artery; and group 2 (n = 10), in which sirolimus-eluting stents were placed...
April 3, 2018: Cardiology Journal
https://www.readbyqxmd.com/read/29610443/one-year-clinical-outcomes-of-forty-eight-millimeter-everolimus-eluting-stent-implanted-in-very-long-lesions-a-propensity-matched-comparison-the-freius-study
#16
Gioel Gabrio Secco, Matteo Tebaldi, Rosario Parisi, Andrea Cuculo, Carlo Di Mario, Pietro Sangiorgio, Alfonso Ielasi, Antonio Centola, Rossella Fattori, Matteo Vercellino, Giovanni Longo, Gianfranco Pistis, Simone Biscaglia, Antonio Ruggiero, Paolo Nicola Marino, Gianluca Campo
BACKGROUND: Long coronary lesions still remain a challenge, with poor immediate results and suboptimal outcomes when compared to class A/B1 lesions. The presence of overlapped segments of metal struts and polymer might trigger an abnormal inflammatory reaction, resulting in a higher restenosis rate. The aim of our study was to evaluate the safety, feasibility, and cost effectiveness of a 48 mm everolimus-eluting stent (EES) during treatment of very long coronary lesions. METHODS AND RESULTS: The FREIUS study is a prospective data collection of consecutive patients undergoing 48 mm EES implantation in six high-volume European centers...
April 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29610442/multicenter-registry-of-real-world-patients-with-severely-calcified-coronary-lesions-undergoing-orbital-atherectomy-1-year-outcomes
#17
Michael S Lee, Evan Shlofmitz, Alec Goldberg, Richard Shlofmitz
OBJECTIVES: We report the 1-year outcomes of real-world patients with severely calcified coronary arteries who underwent orbital atherectomy. BACKGROUND: Percutaneous coronary intervention of heavily calcified lesions is technically challenging and associated with worse clinical outcomes. Modification of severely calcified coronary lesions with orbital atherectomy facilitates stent delivery and expansion. Although we previously reported the safety of orbital atherectomy at 30 days in all comers with severely calcified coronary lesions, including patients who were excluded from the ORBIT II trial, longer-term follow-up is unknown...
April 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29602618/thrombosed-aneurysm-of-the-posterior-inferior-cerebellar-artery-and-lateral-medullary-ischemia-as-the-initial-presentation-of-polyarteritis-nodosa-case-report-and-literature-review
#18
Monique Boukobza, Antoine Dossier, Jean-Pierre Laissy
A 27-year-old woman with a previously undiagnosed polyarteritis nodosa (PAN) developed lateral medullary stroke related to a thrombosed posterior inferior cerebellar artery (PICA)-origin aneurysm. A concurrent thrombosis of the PICA was identified on high-resolution 3-dimensional CUBE T1 magnetic resonance imaging sequence at 3 T. Body computed tomography angiography, magnetic resonance imaging-magnetic resonance angiography, and digital angiography revealed multiple tiny aneurysms of the visceral arteries and bilateral kidney infarcts...
March 27, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29600199/radial-artery-pseudoaneurysm-in-a-post-operative-case-of-midshaft-radius-fracture
#19
Aditya Anand Dahapute, Rohan Bharat Gala, Sanjay B Dhar, Siddharth Viranii, AvaniSudhir Vaishnav
Introduction: Pseudoaneurysms of arteries are not uncommon complications of vessel handling during surgery. Early identification and management is important to prevent disastrous complications such as rupture and thrombosis. Case Report: We describe a case of a 28-year-old male who developed a pseudoaneurysm of the radial artery after being operated by plating for a mid-shaft radius fracture. He presented 2 weeks after surgery with swelling over the forearm which was confirmed to be a pseudoaneurysm after computed tomography angiography...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29593726/pretransplant-iga-anti-beta-2-glycoprotein-i-antibodies-as-a-predictor-of-early-graft-thrombosis-after-renal-transplantation-in-the-clinical-practice-a-multicenter-and-prospective-study
#20
Jose M Morales, Manuel Serrano, Jose Angel Martinez-Flores, Fracisco Javier Gainza, Roberto Marcen, Manuel Arias, Fernando Escuin, Dolores Pérez, Amado Andres, Miguel Angel Martínez, Naroa Maruri, Eva Alvarez, José Luis Castañer, Marcos López-Hoyos, Antonio Serrano
Background: Graft thrombosis is a devastating complication after renal transplantation. We recently described the association of anti-beta-2-glycoprotein-I (IgA-ab2GP1) antibodies with early graft loss mainly caused by thrombosis in a monocenter study. Methods: Multicenter prospective observational cohort study. Setting and participants: Seven hundred forty patients from five hospitals of the Spanish Forum Renal Group transplanted from 2000 to 2002 were prospectively followed-up for 10 years...
2018: Frontiers in Immunology
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