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https://www.readbyqxmd.com/read/29027868/posttraumatic-complications-in-pediatric-skull-fracture-dural-sinus-thrombosis-arterial-dissection-and-cerebrospinal-fluid-leakage
#1
Adedamola Adepoju, Matthew A Adamo
OBJECTIVE Skull fracture is associated with several intracranial injuries. The object of this study was to determine the rate of fracture associated with venous thrombosis, intracranial arterial dissection (ICAD), and cerebrospinal fluid (CSF) leakage in pediatric patients. Further, the authors aimed to highlight the features of pediatric skull fracture that predict poor neurological outcomes. METHOD In this retrospective study, the authors evaluated the records of 258 pediatric patients who had incurred a traumatic skull fracture in the period from 2009 to 2015...
October 13, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29025834/study-protocol-for-a-randomised-controlled-trial-harmonising-optimal-strategy-for-treatment-of-coronary-artery-stenosis-coronary-intervention-with-next-generation-drug-eluting-stent-platforms-and-abbreviated-dual-antiplatelet-therapy-host-idea-trial
#2
Chi-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Kyung Woo Park, Hae-Young Lee, Hyun-Jae Kang, Bon-Kwon Koo, Namho Lee, Tae-Joon Cha, Tae-Hyun Yang, Myung-Ho Jeong, Myeong-Ho Yoon, Seung Uk Lee, Seung Jin Lee, Jin Won Kim, Jin-Man Cho, Kyu-Rock Han, Wook Bum Pyun, Hyo-Soo Kim
INTRODUCTION: We have recently seen the introduction of newer generation drug-eluting stents with ultrathin struts that use advanced polymer technologies. However, the efficacy and safety of these newest stents have not yet been fully explored. In addition, there are still controversies over the optimal duration of dual antiplatelet therapy (DAPT) after stent implantation, particularly for ultrathin stents with the newest polymer technologies. METHODS AND ANALYSIS: The HOST-IDEA trial is a randomised, open-label, multicentre, non-inferiority trial and the first study to directly compare two of these ultrathin sirolimus-eluting stents: Orsiro stent with biodegradable polymer, and polymer-free Coroflex ISAR (CX-ISAR) stent...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29024452/two-year-clinical-outcomes-of-patients-treated-with-overlapping-absorb-scaffolds-an-analysis-of-the-absorb-extend-single-arm-study
#3
J Ribamar Costa, Alexandre Abizaid, Antonio L Bartorelli, Robert Whitbourn, Patrick W Serruys, Pieter C Smits
BACKGROUND: Preclinical data showed that overlapping (OVP) scaffolds might result in delayed healing and strut coverage compared to nonOVP scaffold segments. Furthermore, OVP in patients could result in increased periprocedure myocardial infarction (MI) rate secondary to side branch occlusion; however, little is known whether this may have an impact on long-term clinical outcomes. METHODS: ABSORB EXTEND is a prospective, single-arm, open-label clinical study in which 812 patients were enrolled at 56 sites...
October 10, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29022856/hybrid-technique-for-the-management-of-thoracoabdominal-aortic-thrombosis-and-symptomatic-trans-atlantic-inter-society-consensus-c-aorto-iliac-disease
#4
Aasim Khan, Thodur Vasudevan
Objective Thrombotic disease of the thoracic and abdominal aorta co-existing with aorto-iliac disease is a rare clinical association, which poses a great therapeutic challenge and adds to the complexity of the open surgical repair. Method We describe a case of 53-year-old woman with symptomatic thrombus in the thoracic and abdominal aorta down to the aortic bifurcation, which was successfully treated by Thoracic EndoVascular Aortic Repair via the left subclavian artery, open thrombectomy and aorto-iliac bypass...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/29022210/reducing-catheter-related-thrombosis-using-a-risk-reduction-tool-centered-on-catheter-to-vessel-ratio
#5
Timothy R Spencer, Keegan J Mahoney
In vascular access practices, the internal vessel size is considered important, and a catheter to vessel ratio (CVR) is recommended to assist clinicians in selecting the most appropriate-sized device for the vessel. In 2016, new practice recommendations stated that the CVR can increase from 33 to 45% of the vessels diameter. There has been evidence on larger diameter catheters and increased thrombosis risk in recent literature, while insufficient information established on what relationship to vessel size is appropriate for any intra-vascular device...
October 11, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29020367/clinical-outcomes-of-state-of-the-art-percutaneous-coronary-revascularization-in-patients-with-de-novo-three-vessel-disease-1-year-results-of-the-syntax-ii-study
#6
Javier Escaned, Carlos Collet, Nicola Ryan, Giovanni Luigi De Maria, Simon Walsh, Manel Sabate, Justin Davies, Maciej Lesiak, Raul Moreno, Ignacio Cruz-Gonzalez, Stephan P Hoole, Nick Ej West, J J Piek, Azfar Zaman, Farzin Fath-Ordoubadi, Rodney H Stables, Clare Appleby, Nicolas van Mieghem, Robert Jm van Geuns, Neal Uren, Javier Zueco, Pawel Buszman, Andres Iñiguez, Javier Goicolea, David Hildick-Smith, Andrzej Ochala, Dariusz Dudek, Colm Hanratty, Rafael Cavalcante, Arie Pieter Kappetein, David P Taggart, Gerrit-Anne van Es, Marie-Angèle Morel, Ton de Vries, Yoshinobu Onuma, Vasim Farooq, Patrick W Serruys, Adrian P Banning
Aims: To investigate if recent technical and procedural developments in percutaneous coronary intervention (PCI) significantly influence outcomes in appropriately selected patients with three-vessel (3VD) coronary artery disease. Methods and results: The SYNTAX II study is a multicenter, all-comers, open-label, single arm study that investigated the impact of a contemporary PCI strategy on clinical outcomes in patients with 3VD in 22 centres from four European countries...
August 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020300/impact-of-design-of-coronary-stents-and-length-of-dual-antiplatelet-therapies-on-ischaemic-and-bleeding-events-a-network-meta-analysis-of-64-randomized-controlled-trials-and-102%C3%A2-735-patients
#7
Fabrizio D'Ascenzo, Mario Iannaccone, Gaelle Saint-Hilary, Maurizio Bertaina, Stefanie Schulz-Schüpke, Cheol Wahn Lee, Alaide Chieffo, Gerard Helft, Sebastiano Gili, Umberto Barbero, Giuseppe Biondi Zoccai, Claudio Moretti, Fabrizio Ugo, Maurizio D'Amico, Roberto Garbo, Gregg Stone, Sara Rettegno, Pierluigi Omedè, Federico Conrotto, Christian Templin, Antonio Colombo, Seung-Jung Park, Adnan Kastrati, David Hildick-Smith, Mauro Gasparini, Fiorenzo Gaita
Aims: The differential impact on ischaemic and bleeding events of the type of drug-eluting stent [durable polymer stents [DES] vs. biodegradable polymer stents vs. bioresorbable scaffolds (BRS)] and length of dual antiplatelet therapy (DAPT) remains to be defined. Methods and results: Randomized controlled trials comparing different types of DES and/or DAPT durations were selected. The primary endpoint was Major Adverse Cardiovascular Events (MACE) [a composite of death, myocardial infarction (MI), and target vessel revascularization]...
August 11, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29019892/bright-sinus-appearance-on-arterial-spin-labeling-mr-imaging-aids-to-identify-cerebral-venous-thrombosis
#8
Ji Hee Kang, Tae Jin Yun, Roh-Eul Yoo, Byung-Woo Yoon, A Leum Lee, Koung Mi Kang, Seung Hong Choi, Ji-Hoon Kim, Chul-Ho Sohn, Moon Hee Han
Cerebral venous thrombosis is a potentially lethal disease. Early diagnosis is essential to improve its prognosis. However, its early diagnosis based on conventional imaging modalities remains a challenge in clinical settings. The purpose of this study was to evaluate whether bright sinus appearance on arterial spin-labeling perfusion-weighted image (ASL-PWI) could help identify cerebral venous thrombosis.ASL-PWI of 13 patients who were confirmed as cerebral venous thrombosis based on neurologic symptoms and computed tomography (CT) or magnetic resonance (MR) venography (with/without cerebral angiography) were retrospectively analyzed for the presence or absence of the following: bright signal in dural sinus termed "bright sinus appearance"; and hypoperfusion in brain parenchyma drained by thrombosed sinus...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29018081/platelet-interaction-with-activated-endothelium-mechanistic-insights-from-microfluidics
#9
Daniëlle M Coenen, Tom G Mastenbroek, Judith M E M Cosemans
Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have been proven to be of vital importance to elucidate the mechanisms of platelet thrombus formation after vessel wall injury. In recent years, it has become clear that platelets also act as modulators of inflammatory processes, such as atherosclerosis. A key element herein is the complex crosstalk between platelets, the coagulation system, leukocytes and the activated endothelium. This review provides insight into the platelet-endothelial interface, based on in vitro flow chamber studies and cross referenced with in vivo thrombosis studies...
October 10, 2017: Blood
https://www.readbyqxmd.com/read/28994528/-research-progress-on-regulation-effect-of-panax-notoginseng-saponins-on-mitochondria
#10
REVIEW
Zi-Ping Yang, Yi-Min Bao
Mitochondria is the key energy source of cells and plays an important role in energy synthesis and release, and maintenance of cellular functions. As the most important active ingredients in Chinese medicine pseudo-ginseng, Panax notoginseng saponins(PNS) have pharmacological effects on protecting against thrombosis, dilating blood vessels, lowering the blood pressure, anti-inflammation, and antioxidant, etc. Domestic and foreign studies have shown that PNS participates in regulating mitochondrial energy metabolism, oxidative stress, biosynthesis, apoptosis, mitophagy and the status of membrane channels...
March 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28993230/the-importance-of-blood-platelet-lipid-signaling-in-thrombosis-and-in-sepsis
#11
REVIEW
Fanny Vardon Bounes, Abdulrahman Mujalli, Claire Cenac, Sonia Severin, Pauline Le Faouder, Gaëtan Chicanne, Frédérique Gaits-Iacovoni, Vincent Minville, Marie-Pierre Gratacap, Bernard Payrastre
Blood platelets are the first line of defense against hemorrhages and are also strongly involved in the processes of arterial thrombosis, a leading cause of death worldwide. Besides their well-established roles in hemostasis, vascular wall repair and thrombosis, platelets are now recognized as important players in other processes such as inflammation, healing, lymphangiogenesis, neoangiogenesis or cancer. Evidence is accumulating they are key effector cells in immune and inflammatory responses to host infection...
September 29, 2017: Advances in Biological Regulation
https://www.readbyqxmd.com/read/28993127/retrospective-cohort-study-of-combined-approach-for-trunk-reconstruction-using-arteriovenous-loops-and-free-flaps
#12
Andreas Arkudas, Raymund E Horch, Susanne Regus, Alexander Meyer, Werner Lang, Marweh Schmitz, Anja M Boos, Ingo Ludolph, Justus P Beier
Defect reconstruction of the trunk can be performed using microsurgical free flap transplantation. In cases of missing or inappropriate recipient vessels, microsurgical defect reconstruction of the trunk can be achieved by combining free flaps with arteriovenous loops. Here we present our 5-year experience of trunk reconstruction using AV loops and free flaps in a retrospective evaluation. We analyzed 32 cases of trunk reconstruction using a combined approach of free flap transplantation and arteriovenous loops between 2011 and 2016 regarding postoperative complications and perioperative course...
September 13, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28987841/severe-subarachnoid-hemorrhage-due-to-a-fusiform-lateral-anterior-a1-artery-perforator-aneurysm-with-spontaneous-resolution
#13
Gökce Hatipoglu Majernik, Elvis J Hermann, Christian Hartmann, Peter Raab, Joachim K Krauss
Perforating arteries are thin and long vessels which originate from the main cerebral arteries. Subarachnoidal hemorrhage from a perforator aneurysm is rare. Here, we report on a 70-year-old woman who presented with severe subarachnoid hemorrhage from a fusiform lateral anterior (A1) artery perforator aneurysm. Unexpectedly, digital subtraction angiography was non-diagnostic. MR imaging, however, demonstrated occlusion of the aneurysm secondary to thrombosis. Surgery was performed to remove the associated hematoma, and histopathological examination verified intraaneurysmal thrombosis...
October 5, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28987197/neuropathology-of-cerebrovascular-diseases
#14
Isidro Ferrer, Noemi Vidal
The chapter describes the epidemiology of cerebrovascular diseases, anatomy of the cerebral blood vessels, pathophysiology of ischemia, hypoxia, hypoxemia, anemic hypoxia, histotoxic hypoxia, carbon monoxide damage, hyperoxid brain damage and decompression sickness, and selective cell and regional vulnerability; diseases of the blood vessels including atherosclerosis, hypertensive angiopathy, small vessel disease, inflammatory vascular diseases, cerebral amyloid angiopathies, CADASIL, CARASIL and other diseases that can lead to cerebrovascular occlusion; intracranial and intraspinal aneurysms and vascular malformations; hematologic disorders that can cause cerebral infarct or hemorrhage; brain ischemic damage; and spontaneous intracranial bleeding...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28984118/intracerebral-hemorrhage-in-the-context-of-cerebral-amyloid-angiopathy-and-varied-time-of-onset-of-cerebral-venous-thrombosis-a-case-report
#15
Tadeusz A Mendel, Beata Błażejewska-Hyżorek, Grażyna M Szpak, Tomasz Stępień, Eliza Lewandowska, Sylwia Tarka, Iwona Kurkowska-Jastrzębska, Teresa Wierzba-Bobrowicz
In patients with cerebral venous thrombosis (CVT) the incidence of intracerebral hemorrhage (ICH) is estimated at about 37% and subarachnoid hemorrhage (SAH) at 1% of patients. A case with coincident occurrence of ICH, SAH and CVT in a patient with cerebral amyloid angiopathy (CAA) is reported. A 79-year-old woman was admitted to the Neurological Department after the occurrence of generalized seizures, the first in her life. On admission she was unconscious with right hemiparesis and deviation of eyes to the left...
2017: Folia Neuropathologica
https://www.readbyqxmd.com/read/28983674/contrast-enhanced-ultrasound-ceus-of-the-abdominal-vasculature
#16
REVIEW
Vasileios Rafailidis, Cheng Fang, Gibran T Yusuf, Dean Y Huang, Paul S Sidhu
Vascular diseases account for a significant proportion of abdominal pathology and represent a common referral source for abdominal ultrasonographic examinations. B-mode, color Doppler, and spectral Doppler analyses are well-established in the evaluation of abdominal blood vessels although they may occasionally be limited by lower sensitivity for slow flow visualization or the deeper location of abdominal vascular structures. The introduction of microbubbles as ultrasonographic contrast agents has rendered contrast-enhanced ultrasound (CEUS), a valuable complementary ultrasonographic technique, which is capable of addressing clinically significant problems and guiding patient management...
October 5, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28982317/recent-developments-in-separation-of-low-molecular-weight-heparin-anticoagulants
#17
Radosław Sadowski, Renata Gadzała-Kopciuch, Bogusław Buszewski
The general function of anticoagulants is to prevent blood clotting and growing of the existing clots in blood vessels. In recent years, there has been a significant improvement in developing methods of prevention as well as pharmacologic and surgical treatment of thrombosis. For over the last two decades, low molecular weight heparins (LMWHs) have found their application in the antithrombotic diseases treatment. These types of drugs are widely used in clinical therapy. Despite the biological and medical importance of LMWHs, they have not been completely characterized in terms of their chemical structure...
October 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28980513/early-clinical-outcomes-of-a-novel-rheolytic-directional-thrombectomy-technique-for-patients-with-iliofemoral-deep-vein-thrombosis
#18
Jörn F Dopheide, Tim Sebastian, Rolf P Engelberger, Axel Haine, Nils Kucher
BACKGROUND: Rheolytic thrombectomy (RT) for acute iliofemoral deep vein thrombosis (DVT) with first-generation techniques is often incomplete and adjunctive conventional catheter-directed thrombolysis (CDT) is required in more than half of patients to achieve venous patency. PATIENTS AND METHODS: From the prospective Bern Venous Stent Registry, we investigated rates of primary treatment success, primary patency, and post-thrombotic syndrome (PTS) from 40 consecutive patients (mean age 51 ± 19 years, 45 % women) with acute iliofemoral DVT, treated with a novel directional RT technology and stent placement...
October 5, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28978267/review-of-vascular-graft-studies-in-large-animal-models
#19
Rui Han Liu, Chin Siang Ong, Takuma Fukunishi, Kingsfield Ong, Narutoshi Hibino
As the incidence of cardiovascular disease continues to climb worldwide, there is a corresponding increase in demand for surgical interventions involving vascular grafts. The current gold standard for vascular grafts is autologous vessels, an option often excluded due to disease circumstances. As a result, many patients must resort to prosthetic options. While widely available, prosthetic grafts have been demonstrated to have inferior patency rates compared to autologous grafts due to inflammation and thrombosis...
October 5, 2017: Tissue Engineering. Part B, Reviews
https://www.readbyqxmd.com/read/28974662/outcomes-of-patients-with-a-history-of-coronary-artery-bypass-grafting-who-underwent-orbital-atherectomy-for-severe-coronary-artery-calcification
#20
Michael S Lee, Evan Shlofmitz, Arash Nayeri, John Hollowed, Richard A Shlofmitz
OBJECTIVE: We assess the angiographic and clinical outcomes of patients with a history of coronary artery bypass graft (CABG) surgery who underwent orbital atherectomy for the treatment of severely calcified coronary lesions. BACKGROUND: The presence of severe coronary artery calcification (CAC) increases the complexity of percutaneous coronary intervention (PCI) and is associated with worse clinical outcomes. Patients with a history of CABG who undergo PCI often have comorbidities and are at higher risk for ischemic complications...
October 2017: Journal of Invasive Cardiology
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