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https://www.readbyqxmd.com/read/28936505/the-trimerization-of-acetylenes-involves-a-cascade-of-biradical-and-pericyclic-processes
#1
Gavin O Jones, Zachary J Krebs
Thorough computational studies were performed on mechanisms and energies for the thermal trimerizations of neutral or electron-rich acetylenes used as cross-linkers in organic hard-masks for lithography applications. These studies indicate that the operative mechanism proceeds through initial cyclobutadiene formation via a biradical mechanism. Cyclobutadienes form Dewar benzenes via Diels-Alder cycloadditions, or biradical processes, or both, before producing benzenes by electrocyclic ring-opening reactions...
September 22, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28935683/synaptic-activation-of-putative-sensory-neurons-by-hexamethonium-sensitive-nerve-pathways-in-mouse-colon
#2
Timothy James Hibberd, Lee Travis, Lukasz Wiklendt, Marcello C Costa, Simon J H Brookes, Hongzhen Hu, Damien John Keating, Nick J Spencer
The gastrointestinal tract contains its own independent population of sensory neurons within the gut wall. These sensory neurons have been referred to as intrinsic primary afferent neurons (IPANs) and can be identified by immunoreactivity to calcitonin gene related peptide (CGRP) in mice. A common feature of IPANs is a paucity of fast synaptic inputs observed during sharp microelectrode recordings. Whether this is observed using different recording techniques is of particular interest for understanding the physiology of these neurons and neural circuit modelling...
September 21, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28928232/sdhd-ablation-promotes-thyroid-tumorigenesis-by-inducing-a-stem-like-phenotype
#3
Amruta Ashtekar, Danielle Huk, Alexa Magner, Krista La Perle, Xiaoli Zhang, Jose Piruat, Jose Lopez-Barneo, Sissy Jhiang, Lawrence Kirschner
Mutations in genes encoding enzymes in the tricarboxylic acid cycle (TCA, also known as the Krebs cycle) have been implicated as causative genetic lesions in a number of human cancers, including renal cell cancers, glioblastomas, and pheochromocytomas. In recent studies, missense mutations in the Succinate dehydrogenase (SDH) complex have also been proposed to cause differentiated thyroid cancer. In order to gain mechanistic insight into this process, we generated mice lacking the SDH subunit D (SDHD) in the thyroid...
September 19, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28920462/involvement-of-atrial-natriuretic-peptide-in-abrogated-cardioprotective-effect-of-ischemic-preconditioning-in-ovariectomized-rat-heart
#4
V K Vishwakarma, A Goyal, J K Gupta, P K Upadhyay, H N Yadav
BACKGROUND: Nitric oxide (NO) is an effective mediator of ischemic preconditioning (IPC)-induced cardioprotection. Atrial natriuretic peptide (ANP) is downregulated after ovariectomy, which results in reduction in the level of NO. The present study deals with the investigation of the role of ANP in abrogated cardioprotective effect of IPC in the ovariectomized rat heart. METHODS: Heart was isolated from ovariectomized rat and mounted on Langendorff's apparatus, subjected to 30 min of ischemia and 120 min of reperfusion...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28917928/cell-interactive-alginate-chitosan-biopolymer-systems-with-tunable-mechanics-and-antibody-release-rates
#5
Nathan A Fletcher, Evelyn L Von Nieda, Melissa D Krebs
This work investigates techniques to produce biocompatible hydrogels with tunable stiffness without the addition of crosslinking agents or altering cell binding sites. Alginate and water-soluble chitosan salts were used to form polyelectrolyte complexes (PECs), where the storage and loss moduli could be increased by raising gelation temperatures. The largest change, a 6.5-fold increase in storage modulus, occurred when the crosslinking temperature was increased from 37 to 50°C while using chitosan with chlorine counterions...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28916726/the-nqo1-bioactivatable-drug-%C3%AE-lapachone-alters-the-redox-state-of-nqo1-pancreatic-cancer-cells-causing-perturbation-in-central-carbon-metabolism
#6
Molly A Silvers, Stanislaw Deja, Naveen Singh, Robert A Egnatchik, Jessica Sudderth, Xiuquan Luo, Muhammad S Beg, Shawn C Burgess, Ralph J DeBerardinis, David A Boothman, Matthew E Merritt
Many cancer treatments, such as those for managing recalcitrant tumors like pancreatic ductal adenocarcinoma, cause off-target toxicities in normal, healthy tissue, highlighting the need for more tumor-selective chemotherapies. β-Lapachone is bioactivated by NAD(P)H:quinone oxidoreductase 1 (NQO1). This enzyme exhibits elevated expression in most solid cancers and therefore is a potential cancer-specific target. β-Lapachone's therapeutic efficacy partially stems from the drug's induction of a futile NQO1-mediated redox cycle that causes high levels of superoxide, then peroxide formation, which damages DNA and causes hyperactivation of poly (ADP-ribose) polymerase (PARP), resulting in extensive NAD+/ATP depletion...
September 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28913683/an-evidence-map-of-the-women-veterans-health-research-literature-2008-2015
#7
Elisheva R Danan, Erin E Krebs, Kristine Ensrud, Eva Koeller, Roderick MacDonald, Tina Velasquez, Nancy Greer, Timothy J Wilt
BACKGROUND: Women comprise a growing proportion of Veterans seeking care at Veterans Affairs (VA) healthcare facilities. VA initiatives have accelerated changes in services for female Veterans, yet the corresponding literature has not been systematically reviewed since 2008. In 2015, VA Women's Health Services and the VA Women's Health Research Network requested an updated literature review to facilitate policy and research planning. METHODS: The Minneapolis VA Evidence-based Synthesis Program performed a systematic search of research related to female Veterans' health published from 2008 through 2015...
September 14, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28911343/validation-study-of-maxsignal-%C3%A2-histamine-enzymatic-assay-for-the-detection-of-histamine-in-fish-seafood
#8
Swapna Gone, Nicolas Kosa, Joseph Krebs
Bioo Scientific Corp. has developed a rapid enzymatic quantitative assay for the determination of histamine inseafood. Fresh/frozen tuna, canned tuna, pouched tuna, and frozen mahi mahi samples were used for the validation study under the specific guidelines of the AOAC Research Institute Performance Tested Methods(SM) program. Recoveries ranged from 82 to 107% at concentrations ranging from 6 to 72 ppm, with RSDr values between 0.8 and 6.5% (6-72 ppm). The linearity of the assay ranged from 0 to 108 ppm, with R² values exceeding 0...
September 15, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28910859/investigation-of-the-effects-of-storage-and-freezing-on-mixes-of-heavy-labeled-metabolite-and-amino-acid-standards
#9
Rachel Culp-Hill, Julie A Reisz, Kirk C Hansen, Angelo D'Alessandro
RATIONALE: High-throughput metabolomics has now made it possible for small/medium-sized laboratories to analyze thousands of samples/year from the most diverse biological matrices including biofluids, cell and tissue extracts. In large scale metabolomics studies, stable isotope-labeled standards are increasingly used to normalize for matrix effects and control for technical reproducibility (e.g. extraction efficiency, chromatographic retention times and mass spectrometry signal stability)...
September 14, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28910384/correction-rare-hiv-1-transmitted-founder-lineages-identified-by-deep-viral-sequencing-contribute-to-rapid-shifts-in-dominant-quasispecies-during-acute-and-early-infection
#10
Gustavo H Kijak, Eric Sanders-Buell, Agnes-Laurence Chenine, Michael A Eller, Nilu Goonetilleke, Rasmi Thomas, Sivan Leviyang, Elizabeth A Harbolick, Meera Bose, Phuc Pham, Celina Oropeza, Kultida Poltavee, Anne Marie O'Sullivan, Erik Billings, Melanie Merbah, Margaret C Costanzo, Joanna A Warren, Bonnie Slike, Hui Li, Kristina K Peachman, Will Fischer, Feng Gao, Claudia Cicala, James Arthos, Leigh A Eller, Robert J O'Connell, Samuel Sinei, Lucas Maganga, Hannah Kibuuka, Sorachai Nitayaphan, Mangala Rao, Mary A Marovich, Shelly J Krebs, Morgane Rolland, Bette T Korber, George M Shaw, Nelson L Michael, Merlin L Robb, Sodsai Tovanabutra, Jerome H Kim
[This corrects the article DOI: 10.1371/journal.ppat.1006510.].
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28902095/detection-of-treatment-naive-choroidal-neovascularization-in-age-related-macular-degeneration-by-swept-source-optical-coherence-tomography-angiography
#11
Daniel Ahmed, Martin Stattin, Alexandra Graf, Julia Forster, Carl Glittenberg, Ilse Krebs, Siamak Ansari-Shahrezaei
PURPOSE: To compare the detection rate of choroidal neovascularization (CNV) in treatment-naive neovascular age-related macular degeneration by swept source optical coherence tomography angiography (SS-OCTA, Topcon's DRI Triton) working at 1,050 nm wavelength versus fluorescence angiography. METHODS: Cross-sectional analysis of 156 eyes (107 neovascular age-related macular degeneration and 49 dry AMD) in 98 patients, previously diagnosed by multimodal imaging using fluorescein (FA) and indocyanine green angiography (Heidelberg's Spectralis) in a tertiary retina center, evaluated by SS-OCTA 4...
September 4, 2017: Retina
https://www.readbyqxmd.com/read/28901703/development-of-a-structured-diabetes-self-management-education-program-specific-to-the-cultural-and-ethnic-population-of-new-zealand
#12
Eirean Gamble, Amber Parry-Strong, Kirsten J Coppell, Lynn McBain, Lorna J Bingham, Liz Dutton, Sera Tapu-Ta'ala, Robert B W Smith, Joe Howells, Howard Metekingi, Jeremy D Krebs
AIM: To develop and pilot a diabetes self-management education (DSME) program specific to the needs of New Zealanders with type 2 diabetes mellitus (T2DM). METHODS: There were two parts in the present study. The first was the development of the program. This involved a literature review, consultation with end-user groups and drafting the content of the program. In the second part, the program was tested and modified according to feedback provided by both participants and facilitators...
September 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28893675/design-recruitment-outcomes-and-sample-characteristics-of-the-strategies-for-prescribing-analgesics-comparative-effectiveness-space-trial
#13
Erin E Krebs, Agnes C Jensen, Sean Nugent, Beth DeRonne, Indulis Rutks, David Leverty, Amy Gravely, Siamak Noorbaloochi, Matthew J Bair, Kurt Kroenke
This manuscript describes the study protocol, recruitment outcomes, and baseline participant characteristics for the Strategies for Prescribing Analgesics Comparative Effectiveness (SPACE) trial. SPACE is a pragmatic randomized comparative effectiveness trial conducted in multiple VA primary care clinics within one VA health care system. The objective was to compare benefits and harms of opioid therapy versus non-opioid medication therapy over 12months among patients with moderate-to-severe chronic back pain or hip/knee osteoarthritis pain despite analgesic therapy; patients already receiving regular opioid therapy were excluded...
September 8, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28890282/opioid-dosing-trends-over-eight-years-among-us-veterans-with-musculoskeletal-disorders-after-returning-from-service-in-support-of%C3%A2-recent-conflicts
#14
Ling Han, Heather Allore, Joseph Goulet, Harini Bathulapali, Melissa Skanderson, Cynthia Brandt, Sally Haskell, Erin Krebs
PURPOSE: To examine long-term opioid dosing trends among Veterans with chronic pain. METHODS: We identified 79,015 Veterans with musculoskeletal disorders who were dispensed greater than or equal to 1 opioid prescriptions between 2002 and 2009 after returning from recent conflicts. Opioid-dosing trends were examined using a generalized estimating equation while accounting for patient characteristics, temporal and geographic confounding. RESULTS: In total, 472,819 opioid prescriptions were dispensed (mean ± standard deviation: 6...
August 24, 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28888099/polydrug-use-and-its-association-with-drug-treatment-outcomes-among-primary-heroin-methamphetamine-and-cocaine-users
#15
Linwei Wang, Jeong Eun Min, Emanuel Krebs, Elizabeth Evans, David Huang, Lei Liu, Yih-Ing Hser, Bohdan Nosyk
BACKGROUND: Polydrug use may challenge effective treatment for substance use disorders. We evaluate whether secondary substance use modifies the association between treatment and primary drug use among primary heroin, cocaine and methamphetamine (MA) users. METHODS: Data were obtained from prospective cohort studies on people who use illicit drugs (PWUD) in California, USA. Using repeated monthly data on self-reported secondary substance use (heroin, cocaine, MA, alcohol or marijuana; ≥1day in a month), primary drug use (≥1day in a month), and treatment participation, collected via timeline follow-back, we fitted generalized linear mixed multiple regression models controlling for potential confounders to examine the interactions between treatment and secondary substance use on the odds of primary heroin, cocaine and MA use, respectively...
September 6, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28884793/using-vascular-landmarks-to-orient-3d-optical-coherence-tomography-images-of-the-mouse-eye
#16
Mark P Krebs
Comparing 3D structural information obtained by optical coherence tomography (OCT) requires accurate alignment of images acquired from individual subjects. Despite the widespread use of OCT to image the anterior and posterior mouse eye, few approaches to align the resulting image data have been described, in part due to a lack of well-characterized landmarks that are suitable for alignment. Here, we provide an OCT acquisition and analysis protocol that incorporates the use of the long posterior ciliary arteries as landmarks...
September 8, 2017: Current Protocols in Mouse Biology
https://www.readbyqxmd.com/read/28883190/extending-the-query-language-of-a-data-warehouse-for-patient-recruitment
#17
Georg Dietrich, Maximilian Ertl, Georg Fette, Mathias Kaspar, Jonathan Krebs, Daniel Mackenrodt, Stefan Störk, Frank Puppe
Patient recruitment for clinical trials is a laborious task, as many texts have to be screened. Usually, this work is done manually and takes a lot of time. We have developed a system that automates the screening process. Besides standard keyword queries, the query language supports extraction of numbers, time-spans and negations. In a feasibility study for patient recruitment from a stroke unit with 40 patients, we achieved encouraging extraction rates above 95% for numbers and negations and ca. 86% for time spans...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28883177/a-customizable-importer-for-the-clinical-data-warehouses-padawan-and-i2b2
#18
Georg Fette, Mathias Kaspar, Georg Dietrich, Maximilian Ertl, Jonathan Krebs, Stefan Stoerk, Frank Puppe
In recent years, clinical data warehouses (CDW) storing routine patient data have become more and more popular to support scientific work in the medical domain. Although CDW systems provide interfaces to import new data, these interfaces have to be used by processing tools that are often not included in the systems themselves. In order to establish an extraction-transformation-load (ETL) workflow, already existing components have to be taken or new components have to be developed to perform the load part of the ETL...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28883175/semi-automatic-terminology-generation-for-information-extraction-from-german-chest-x-ray-reports
#19
Jonathan Krebs, Hamo Corovic, Georg Dietrich, Max Ertl, Georg Fette, Mathias Kaspar, Markus Krug, Stefan Stoerk, Frank Puppe
Extraction of structured data from textual reports is an important subtask for building medical data warehouses for research and care. Many medical and most radiology reports are written in a telegraphic style with a concatenation of noun phrases describing the presence or absence of findings. Therefore a lexico-syntactical approach is promising, where key terms and their relations are recognized and mapped on a predefined standard terminology (ontology). We propose a two-phase algorithm for terminology matching: In the first pass, a local terminology for recognition is derived as close as possible to the terms used in the radiology reports...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28878294/spectral-control-of-elastic-dynamics-in-metallic-nano-cavities
#20
Henning Ulrichs, Dennis Meyer, Florian Döring, Christian Eberl, Hans-Ulrich Krebs
We show how the elastic response of metallic nano-cavities can be tailored by tuning the interplay with an underlying phononic superlattice. In particular, we exploit ultrafast optical excitation in order to address a resonance mode in a tungsten thin film, grown on top of a periodic MgO/ZrO2 multilayer. Setting up a simple theoretical model, we can explain our findings by the coupling of the resonance in the tungsten to an evanescent surface mode of the superlattice. To demonstrate a second potential benefit of our findings besides characterization of elastic properties of multilayer samples, we show by micromagnetic simulation how a similar structure can be utilized for magneto-elastic excitation of exchange-dominated spin waves...
September 6, 2017: Scientific Reports
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