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https://www.readbyqxmd.com/read/28535516/citrate-anticoagulation-during-continuous-renal-replacement-therapy
#1
Davide Ricci, Laura Panicali, Maria Grazia Facchini, Elena Mancini
During extracorporeal dialysis, some anticoagulation strategy is necessary to prevent the coagulation of blood. Heparin has historically been used as an anticoagulant because of its efficacy combined with low cost. However, a variable incidence of hemorrhagic complications (5-30%) has been documented in patients undergoing continuous renal replacement therapy (CRRT) with heparin as an anticoagulant. Citrate has anticoagulation properties secondary to its ability to chelate calcium, which is necessary for the coagulation cascade...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28533563/why-do-the-boreal-forest-ecosystems-of-northwestern-europe-differ-from-those-of-western-north-america
#2
Rudy Boonstra, Harry P Andreassen, Stan Boutin, Jan Hušek, Rolf A Ims, Charles J Krebs, Christina Skarpe, Petter Wabakken
The boreal forest is one of the largest terrestrial biomes on Earth. Conifers normally dominate the tree layer across the biome, but other aspects of ecosystem structure and dynamics vary geographically. The cause of the conspicuous differences in the understory vegetation and the herbivore-predator cycles between northwestern Europe and western North America presents an enigma. Ericaceous dwarf shrubs and 3- to 4-year vole-mustelid cycles characterize the European boreal forests, whereas tall deciduous shrubs and 10-year snowshoe hare-lynx cycles characterize the North American ones...
September 1, 2016: Bioscience
https://www.readbyqxmd.com/read/28531964/non-electron-transfer-chain-mitochondrial-defects-differently-regulate-hif-1%C3%AE-degradation-and-transcription
#3
Antonina N Shvetsova, Daniela Mennerich, Juha M Kerätär, J Kalervo Hiltunen, Thomas Kietzmann
Mitochondria are the main consumers of molecular O2 in a cell as well as an abundant source of reactive oxygen species (ROS). Both, molecular oxygen and ROS are powerful regulators of the hypoxia-inducible factor-1α-subunit (HIF-α). While a number of mechanisms in the oxygen-dependent HIF-α regulation are quite well known, the view with respect to mitochondria is less clear. Several approaches using pharmacological or genetic tools targeting the mitochondrial electron transport chain (ETC) indicated that ROS, mainly formed at the Rieske cluster of complex III of the ETC, are drivers of HIF-1α activation...
May 8, 2017: Redox Biology
https://www.readbyqxmd.com/read/28528263/influences-of-land-use-and-antecedent-dry-weather-period-on-pollution-level-and-ecological-risk-of-heavy-metals-in-road-deposited-sediment
#4
Jin Zhang, Pei Hua, Peter Krebs
Road-deposited sediment and its adsorbed pollutants have been regarded as significant sources of urban diffuse pollution. In this study, the solid-phase concentrations (mg/g), surface load (mg/m(2)) and chemical fractionation of zinc (Zn), copper (Cu) and cadmium (Cd) were determined. Geo-accumulation (Igeo) and ecological risk (RI) indexes were employed for metal risk assessment. Results show that the highest solid-phase concentrations of Zn and Cu were usually found at an industrial area. However, Cd had the highest solid-phase concentrations at a rural area, followed by a commercial area...
May 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28526749/the-origin-and-evolution-of-human-glutaminases-and-their-atypical-c-terminal-ankyrin-repeats
#5
Camila Cristina Pascoal, Zeyaul Islam, Douglas Adamoski, Igor Monteze Ferreira, Ricardo Diogo Righetto, Jefferson Bettini, Rodrigo Villares Portugal, Wyatt W Yue, Ana Gonzalez, Sandra Martha Gomes Dias, Andre Luis Berteli Ambrosio
On the basis of tissue-specific enzyme activity and inhibition by catalytic products, Hans Krebs first demonstrated the existence of multiple glutaminases in mammals. Currently, two human genes are known to encode at least four glutaminase isoforms. However, the phylogeny of these medically relevant enzymes remains unclear, prompting us to investigate their origin and evolution. Using prokaryotic and eukaryotic glutaminase sequences, we built a phylogenetic tree whose topology suggested that the multidomain architecture was inherited from bacterial ancestors, probably simultaneously with the hosting of the proto-mitochondrion endosymbiont...
May 19, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28523487/unplanned-reoperation-following-colorectal-surgery-indications-and-operations
#6
Alex D Michaels, Matthew G Mullen, Christopher A Guidry, Elizabeth D Krebs, Florence E Turrentine, Traci L Hedrick, Charles M Friel
AIM: Prior studies have demonstrated a reoperation rate ranging from 5.8 to 7.6% following colorectal surgery. However, the indications for reoperation have not been extensively evaluated. We aimed to describe the indications for reoperation and associated procedures following colorectal resection. METHODS: This is a retrospective cohort study of all patients undergoing colorectal resection at a single institution from 2003 to 2013. For patients who returned to the operating room, the primary indication was categorized into mutually exclusive categories and all procedures performed within 30 days of the initial operation were indexed...
May 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28522647/prkar1a-mutation-causing-pituitary-dependent-cushing-disease-in-a-patient-with-carney-complex
#7
Florian W Kiefer, Yvonne Winhofer, Donato Iacovazzo, Marta Korbonits, Stefan Wolfsberger, Engelbert Knosp, Franz Trautinger, Romana Höftberger, Michael Krebs, Anton Luger, Alois Gessl
CONTEXT: Carney complex (CNC) is an autosomal dominant condition caused, in most cases, by an inactivating mutation of the PRKAR1A gene, which encodes for the type 1 alpha regulatory subunit of protein kinase A. CNC is characterized by the occurrence of endocrine overactivity, myxomas and typical skin manifestations. Cushing syndrome due to primary pigmented nodular adrenocortical disease (PPNAD) is the most frequent endocrine disease observed in CNC. CASE DESCRIPTION: Here we describe the first case of a patient with CNC and adrenocorticotropic hormone (ACTH)-dependent Cushing disease due to a pituitary corticotroph adenoma...
May 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28520603/does-negative-pressure-wound-therapy-for-the-open-abdomen-benefit-the-patient-a-retrospective-cohort-study
#8
Bojan Krebs, Tomaž Jagrič
OBJECTIVE: Negative-pressure wound therapy (NPWT) is the most modern and sophisticated method of temporary abdominal closure. The aim of the study was to determine the significant predictors for mortality in patients with NPWT. SETTING: University Clinical Centre Maribor, Slovenia MATERIALS AND METHODS:: The authors performed a retrospective cohort study of all patients treated with NPWT between January 1, 2011, and December 31, 2014. RESULTS: In the univariate analysis, the type of wound closure, more than 7 NPWT changes, the total days with NPWT, and time to wound closure were significantly associated with death of the patient...
June 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28513837/maternal-near-miss-in-low-resource-areas
#9
Robert L Goldenberg, Sarah Saleem, Sumera Ali, Janet L Moore, Adrien Lokangako, Antoinette Tshefu, Musaku Mwenechanya, Elwyn Chomba, Ana Garces, Lester Figueroa, Shivaprasad Goudar, Bhalachandra Kodkany, Archana Patel, Fabian Esamai, Paul Nsyonge, Margo S Harrison, Melissa Bauserman, Carl L Bose, Nancy F Krebs, K Michael Hambidge, Richard J Derman, Patricia L Hibberd, Edward A Liechty, Dennis D Wallace, Jose M Belizan, Menachem Miodovnik, Marion Koso-Thomas, Waldemar A Carlo, Alan H Jobe, Elizabeth M McClure
OBJECTIVE: To describe the Global Network Near-Miss Maternal Mortality System and its application in seven sites. METHODS: In a population-based study, pregnant women eligible for enrollment in the Maternal and Newborn Health Registry at seven sites (Democratic Republic of the Congo; Guatemala; Belagavi and Nagpur, India; Kenya; Pakistan; and Zambia) between January 2014 and April 2016 were screened to identify those likely to have a near-miss event. The WHO maternal near-miss criteria were modified for low-resource settings...
May 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28513622/human-milk-insulin-is-related-to-maternal-plasma-insulin-and-bmi-but-other-components-of-human-milk-do-not-differ-by-bmi
#10
B E Young, Z Patinkin, C Palmer, B de la Houssaye, L A Barbour, T Hernandez, J E Friedman, N F Krebs
BACKGROUND/OBJECTIVES: The impact of maternal BMI and insulin sensitivity on bioactive components of human milk (HM) is not well understood. As the prevalence of obesity and diabetes rises, it is increasingly critical that we understand how maternal BMI and hormones associated with metabolic disease relate to concentrations of bioactive components in HM. SUBJECTS/METHODS: This longitudinal cohort design followed 48 breastfeeding mothers through the first four months of lactation, collecting fasting morning HM samples at 2-weeks and 1, 2, 3 and 4-months, and fasting maternal blood at 2-weeks and 4-months...
May 17, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28510035/ketone-bodies-as-a-possible-adjuvant-to-ketogenic-diet-in-pdhc-deficiency-but-not-in-glut1-deficiency
#11
F Habarou, N Bahi-Buisson, E Lebigot, C Pontoizeau, M T Abi-Warde, A Brassier, K H Le Quan Sang, C Broissand, S Vuillaumier-Barrot, A Roubertie, A Boutron, C Ottolenghi, P de Lonlay
OBJECTIVE: Ketogenic diet is the first line therapy for neurological symptoms associated with pyruvate dehydrogenase deficiency (PDHD) and intractable seizures in a number of disorders, including GLUT1 deficiency syndrome (GLUT1-DS). Because high-fat diet raises serious compliance issues, we investigated if oral L,D-3-hydroxybutyrate administration could be as effective as ketogenic diet in PDHD and GLUT1-DS. METHODS: We designed a partial or total progressive substitution of KD with L,D-3-hydroxybutyrate in three GLUT1-DS and two PDHD patients...
May 17, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28505989/pediatric-robotic-rehabilitation-current-knowledge-and-future-trends-in-treating-children-with-sensorimotor-impairments
#12
Konstantinos P Michmizos, Hermano Igo Krebs
BACKGROUND: Robot-aided sensorimotor therapy imposes highly repetitive tasks that can translate to substantial improvement when patients remain cognitively engaged into the clinical procedure, a goal that most children find hard to pursue. Knowing that the child's brain is much more plastic than an adult's, it is reasonable to expect that the clinical gains observed in the adult population during the last two decades would be followed up by even greater gains in children. Nonetheless, and despite the multitude of adult studies, in children we are just getting started: There is scarcity of pediatric robotic rehabilitation devices that are currently available and the number of clinical studies that employ them is also very limited...
May 11, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28505988/intensive-seated-robotic-training-of-the-ankle-in-patients-with-chronic-stroke-differentially-improves-gait
#13
Johanna L Chang, Regina Y Lin, Maira Saul, Philip J Koch, Hermano Igo Krebs, Bruce T Volpe
BACKGROUND: Robotic driven treatment plans targeting isolated joints of the upper limb have improved the sensorimotor condition of patients with stroke. Similar intensive efforts to allay lower limb gait impairment have not been so successful. In patients with stroke, targeted robot assisted training of the ankle joint, in a seated position, has demonstrated significant alterations in ankle stiffness and foot-ankle orientation at foot strike which may provide a new treatment option for gait impairment...
May 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28505987/improved-grasp-function-with-transcranial-direct-current-stimulation-in-chronic-spinal-cord-injury
#14
Mar Cortes, Ana Heloisa Medeiros, Aasta Gandhi, Peter Lee, Hermano Igo Krebs, Gary Thickbroom, Dylan Edwards
BACKGROUND: Recovering hand function has important implications for improving independence of patients with tetraplegia after traumatic spinal cord injury (SCI). Transcranial direct current stimulation (tDCS) is a noninvasive rehabilitation technique that has potential to improve motor function. OBJECTIVE: To investigate the effects of one session of 1 mA, 2 mA, and sham anodal tDCS (a-tDCS) in the upper extremity (hand) motor performance (grasp and lease) in patients with chronic cervical SCI...
May 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28505984/on-a-unique-fellow-and-a-good-friend-celebrating-the-life-of-stefan-hesse-and%C3%A2-his%C3%A2-contributions-to-rehabilitation-robotics-1960-2016
#15
Hermano Igo Krebs
No abstract text is available yet for this article.
May 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28495542/endothelial-function-is-preserved-in-veins-harvested-by-either-endoscopic-or-surgical-techniques
#16
Adam R Wheeler, Daniel E Kendrick, Matt T Allemang, Andre F Gosling, Ann H Kim, Alfred Hausladen, Vikram S Kashyap
OBJECTIVES: Endoscopic vein harvest for lower extremity arterial bypass grafting has been questioned due to concern for endothelial damage during procurement. We sought to compare Nitric Oxide (NO)-mediated endothelial dependent relaxation (EDR) in vein segments harvested using open surgical (OH) versus endoscopic (EH) techniques. METHODS: Saphenous vein segments were harvested for lower extremity bypass, and a single, minimally handled section of saphenous vein, free of branches, was taken from the end of the graft...
May 8, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28490802/transcriptome-analysis-of-dominant-negative-brd4-mutants-identifies-brd4-specific-target-genes-of-small-molecule-inhibitor-jq1
#17
Tim-Michael Decker, Michael Kluge, Stefan Krebs, Nilay Shah, Helmut Blum, Caroline C Friedel, Dirk Eick
The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting the positive elongation factor P-TEFb. Small molecule inhibitor JQ1 competitively binds the bromodomains of Brd4 and displaces the protein from acetylated histones. However, it remains unclear whether genes targeted by JQ1 are mainly regulated by Brd4 or by other bromodomain proteins such as Brd2 and Brd3...
May 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28482923/transplacental-transmission-of-theileria-orientalis-occurs-at-a-low-rate-in-field-affected-cattle-infection-in-utero-does-not-appear-to-be-a-major-cause-of-abortion
#18
Emma Swilks, Shayne A Fell, Jade F Hammer, Narelle Sales, Gaye L Krebs, Cheryl Jenkins
BACKGROUND: Bovine theileriosis, caused by the haemoprotozoan Theileria orientalis, is an emerging disease in East Asia and Australasia. Previous studies have demonstrated transplacental transmission of various Theileria spp. but molecular confirmation of transplacental transmission of T. orientalis has never been confirmed in the field. In this study, cow-calf (< 48 h old) pairs were sampled across 3 herds; opportunistic samples from aborted foetuses or stillborn calves were also examined...
May 8, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28477296/analysis-of-complexes-of-metabolites-with-europium-tetracycline-using-capillary-electrophoresis-coupled-with-laser-induced-luminescence-detection
#19
Douglas B Craig, Zachery Hiebert
Glycolysis and Krebs cycle intermediates were incubated with Eu(3+)-tetracycline and separated using capillary electrophoresis utilizing post-column laser-induced luminescence detection in a sheath flow cuvette. 3-phopshoglycerate, phosphoenolpyruvate, adenosine diphosphate, phosphate, citrate and oxaloacetate were detected at a concentration of 100 μM or lower. When all these detected metabolites were contained within the same sample it was found that they interfered with one another. Of all the metabolites, oxaloacetate showed the highest detectability...
June 2017: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
https://www.readbyqxmd.com/read/28477266/combination-of-multiple-neural-crest-migration-assays-to-identify-environmental-toxicants-from-a-proof-of-concept-chemical-library
#20
Johanna Nyffeler, Xenia Dolde, Alice Krebs, Kevin Pinto-Gil, Manuel Pastor, Mamta Behl, Tanja Waldmann, Marcel Leist
Many in vitro tests have been developed to screen for potential neurotoxicity. However, only few cell function-based tests have been used for comparative screening, and thus experience is scarce on how to confirm and evaluate screening hits. We addressed these questions for the neural crest cell migration test (cMINC). After an initial screen, a hit follow-up strategy was devised. A library of 75 compounds plus internal controls (NTP80-list), assembled by the National Toxicology Program of the USA (NTP) was used...
May 5, 2017: Archives of Toxicology
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