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https://www.readbyqxmd.com/read/28223908/elevated-urinary-glyphosate-and-clostridia-metabolites-with-altered-dopamine-metabolism-in-triplets-with-autistic-spectrum-disorder-or-suspected-seizure-disorder-a-case-study
#1
William Shaw
CONTEXT: Autism is a neurodevelopmental disorder for which a number of genetic, environmental, and nutritional causes have been proposed. Glyphosate is used widely as a crop desiccant and as an herbicide in fields of genetically modified foods that are glyphosate resistant. Several researchers have proposed that it may be a cause of autism, based on epidemiological data that correlates increased usage of glyphosate with an increased autism rate. OBJECTIVE: The current study was intended to determine if excessive glyphosate was present in the triplets and their parents and to evaluate biochemical findings for the family to determine the potential effects of its presence...
February 2017: Integrative Medicine
https://www.readbyqxmd.com/read/28223000/ecs-meeting
#2
EDITORIAL
Jacques Haiech, Claus W Heizmann, Joachim Krebs
No abstract text is available yet for this article.
February 13, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28219702/genetic-alterations-in-krebs-cycle-and-its-impact-on-cancer-pathogenesis
#3
REVIEW
Karishma Sajnani, Farhadul Islam, Robert Anthony Smith, Vinod Gopalan, Alfred King-Yin Lam
Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle enzymes favour the shift of cancer cells from oxidative phosphorylation to anaerobic glycolysis. Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted in many cancers...
February 17, 2017: Biochimie
https://www.readbyqxmd.com/read/28219356/bacopa-monnieri-extract-increases-rat-coronary-flow-and-protects-against-myocardial-ischemia-reperfusion-injury
#4
Sirintorn Srimachai, Sylvie Devaux, Celine Demougeot, Sarawut Kumphune, Nina D Ullrich, Ernst Niggli, Kornkanok Ingkaninan, Natakorn Kamkaew, C Norman Scholfield, Sompol Tapechum, Krongkarn Chootip
BACKGROUND: This study explored Bacopa monnieri, a medicinal Ayurvedic herb, as a cardioprotectant against ischemia/reperfusion injury using cardiac function and coronary flow as end-points. METHODS: In normal isolated rat hearts, coronary flow, left ventricular developed pressure, heart rate, and functional recovery were measured using the Langendorff preparation. Hearts were perfused with either (i) Krebs-Henseleit (normal) solution, (control), or with 30, 100 μg/ml B...
February 20, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28216953/therapeutic-potential-of-alpha-ketoglutarate-against-acetaminophen-induced-hepatotoxicity-in-rats
#5
Lalita Mehra, Yasha Hasija, Gaurav Mittal
OBJECTIVE: Alpha-ketoglutarate (α-KG) is a cellular intermediary metabolite of Krebs cycle, involved in energy metabolism, amino acid synthesis, and nitrogen transport. It is available over-the-counter and marketed as a nutritional supplement. There is a growing body of evidence to suggest that dietary α-KG has the potential to maintain cellular redox status and thus can protect various oxidative stress induced disease states. The aim of the present study was to investigate the hepatoprotective role of α-KG in acetaminophen (APAP) induced toxicity in rats...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28214933/findings-from-american-indian-needs-assessments
#6
Linda Burhansstipanov, Linda U Krebs, Lisa Harjo, Kathleen Ragan, Judith Salmon Kaur, Vickie Marsh, Dewey Painter
Because of decreased access and dismal survival rates, strategies need to be developed to increase cancer awareness and facilitate cancer prevention, early detection, and screening activities within American Indian (AI) populations. The purpose of this study was to develop a locally tailored needs assessment to collect cancer prevention, control, and risk factor information and knowledge, attitude, and perceived behavior (hereafter referred to as "needs assessment") data from 500 community members living in 3 geographically diverse settings: the Southeastern USA, the Rocky Mountain region, and the Northern Plains...
February 18, 2017: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28214704/corrigendum-to-sustained-localized-presentation-of-rna-interfering-molecules-from-in-situ-forming-hydrogels-to-guide-stem-cell-osteogenic-differentiation-biomaterials-35-24-2014-6278-6286
#7
Minh K Nguyen, Oju Jeon, Melissa D Krebs, Daniel Schapira, Eben Alsberg
No abstract text is available yet for this article.
February 16, 2017: Biomaterials
https://www.readbyqxmd.com/read/28213770/myosin-heavy-chain-and-cardiac-troponin-t-damage-is-associated-with-impaired-myofibrillar-atpase-activity-contributing-to-sarcomeric-dysfunction-in-ca-2-paradox-rat-hearts
#8
Árpád Kovács, Judit Kalász, Enikő T Pásztor, Attila Tóth, Zoltán Papp, Naranjan S Dhalla, Judit Barta
This study aimed to explore the potential contribution of myofibrils to contractile dysfunction in Ca(2+)-paradox hearts. Isolated rat hearts were perfused with Krebs-Henseleit solution (Control), followed by Ca(2+)-depletion, and then Ca(2+)-repletion after Ca(2+)-depletion (Ca(2+)-paradox) by Langendorff method. During heart perfusion left ventricular developed pressure (LVDP), end-diastolic pressure (LVEDP), rate of pressure development (+ dP/dt), and pressure decay (-dP/dt) were registered. Control LVDP (127...
February 17, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28213332/shear-stress-enhances-ca-2-sparks-through-nox2-dependent-mitochondrial-reactive-oxygen-species-generation-in-rat-ventricular-myocytes
#9
Joon-Chul Kim, Jun Wang, Min-Jeong Son, Sun-Hee Woo
Shear stress enhances diastolic and systolic Ca(2+) concentration in ventricular myocytes. Here, using confocal Ca(2+) imaging in rat ventricular myocytes, we assessed the effects of shear stress (~16dyn/cm(2)) on the frequency of spontaneous Ca(2+) sparks and explored the mechanism underlying shear-mediated Ca(2+) spark regulation. The frequency of Ca(2+) sparks was immediately increased by shear stress (by ~80%), and increased further (by ~150%) during prolonged exposure (20s). The 2-D size and duration of individual sparks were increased by shear stimulation...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28211997/highly-conformal-ni-micromesh-as-a-current-collecting-front-electrode-for-reduced-cost-si-solar-cell
#10
Nikita Gupta, K D Mallikharjuna Rao, Ritu Gupta, Frederik C Krebs, Giridhar U Kulkarni
Despite relatively high manufacturing cost, crystalline-Si solar cell continues to hold promising future due to its high energy conversion efficiency and long life. As regards cost, one pertinent issue is the top electrode metallization of textured cell surface, which typically involves screen printing of silver paste. The associated disadvantages call for alternative methods that can lower the cost without compromising the solar cell efficiency. In the present work, a highly interconnected one dimensional (1D) metal wire network has been employed as front electrode on conventional Si wafers...
February 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28209036/-primary-culture-and-functional-identification-of-distal-pulmonary-artery-smooth-muscle-cells-in-mice
#11
M C Li, Y Q Chen, C T Zhang, Q Jiang, W J Lu, J Wang
Objective: To establish a method of isolation and primary culture of mice distal pulmonary artery smooth muscle cells (PASMCs) and identify the functional properties. Methods: PASMCs were harvested from the distal pulmonary artery (PA) tissue of mice by enzymatic digestion of collagenaseⅠand papain; and the growth characteristics were observed under inverted microscope and identified by Immunofluorescence technique. Effects on the intracellular calcium ion concentration of distal PASMCs were detected by Fura-2-AM fluorescent probe tracer under a fluorescence microscope in Krebs solution containing clopiazonic acid (CPA) and nifedipin (Nif)...
February 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28208702/the-glutamate-dehydrogenase-pathway-and-its-roles-in-cell-and-tissue-biology-in-health-and-disease
#12
REVIEW
Andreas Plaitakis, Ester Kalef-Ezra, Dimitra Kotzamani, Ioannis Zaganas, Cleanthe Spanaki
Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD(P)⁺ to NAD(P)H. It is found in all living organisms serving both catabolic and anabolic reactions. In mammalian tissues, oxidative deamination of glutamate via GDH generates α-ketoglutarate, which is metabolized by the Krebs cycle, leading to the synthesis of ATP. In addition, the GDH pathway is linked to diverse cellular processes, including ammonia metabolism, acid-base equilibrium, redox homeostasis (via formation of fumarate), lipid biosynthesis (via oxidative generation of citrate), and lactate production...
February 8, 2017: Biology
https://www.readbyqxmd.com/read/28207729/proposed-new-industry-code-on-unhealthy-food-marketing-to-children-and-young-people-will-it-make-a-difference
#13
Boyd Swinburn, Stefanie Vandevijvere, Alistair Woodward, Andrew Hornblow, Ann Richardson, Barbara Burlingame, Barry Borman, Barry Taylor, Bernhard Breier, Bruce Arroll, Bernadette Drummond, Cameron Grant, Chris Bullen, Clare Wall, Cliona Ni Mhurchu, David Cameron-Smith, David Menkes, David Murdoch, Dee Mangin, Diana Lennon, Diana Sarfati, Doug Sellman, Elaine Rush, Faafetai Sopoaga, George Thomson, Gerry Devlin, Gillian Abel, Harvey White, Jane Coad, Janet Hoek, Jennie Connor, Jeremy Krebs, Jeroen Douwes, Jim Mann, John McCall, John Broughton, John D Potter, Les Toop, Lesley McCowan, Louise Signal, Lutz Beckert, Mark Elwood, Marlena Kruger, Mauro Farella, Michael Baker, Michael Keall, Murray Skeaff, Murray Thomson, Nick Wilson, Nicholas Chandler, Papaarangi Reid, Patricia Priest, Paul Brunton, Peter Crampton, Peter Davis, Philip Gendall, Philippa Howden-Chapman, Rachael Taylor, Richard Edwards, Robert Beaglehole, Robert Doughty, Robert Scragg, Robin Gauld, Robert McGee, Rod Jackson, Roger Hughes, Roger Mulder, Ruth Bonita, Rozanne Kruger, Sally Casswell, Sarah Derrett, Shanthi Ameratunga, Simon Denny, Simon Hales, Sue Pullon, Susan Wells, Tim Cundy, Tony Blakely
Reducing the exposure of children and young people to the marketing of unhealthy foods is a core strategy for reducing the high overweight and obesity prevalence in this population. The Advertising Standards Authority (ASA) has recently reviewed its self-regulatory codes and proposed a revised single code on advertising to children. This article evaluates the proposed code against eight criteria for an effective code, which were included in a submission to the ASA review process from over 70 New Zealand health professors...
February 17, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28204948/blood-trace-evidence-on-washed-textiles-a-systematic-approach
#14
Carolin Edler, A Gehl, J Kohwagner, M Walther, O Krebs, C Augustin, A Klein
Luminol has been used for a long time for detecting latent blood traces during police investigations because it is easy to use and does not pose any health risks, while providing trace evidence for DNA analysis. It is often the method of choice for examining clothing. Clothes worn during the offense are often destroyed or washed afterwards by the offenders. The purpose of this study is to show the possibilities of blood and DNA detection on washed clothes by documenting the macroscopic results and their chemiluminescence after washing...
February 15, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28198525/an-investigation-on-cardioprotective-potential-of-marrubium-vulgare-aqueous-fraction-against-ischemia-reperfusion-injury-in-isolated-rat-heart
#15
Alireza Garjani, Dena Tila, Sanaz Hamedeyazdan, Haleh Vaez, Maryam Rameshrad, Mahdiyeh Pashaii, Fatemeh Fathiazad
The aim of this study was to evaluate the cardioprotective effects of aqueous fraction of M. vulgare hydroalcoholic extract on cardiac parameters in ischemic-reperfused isolated rat hearts. The aerial parts of the plant were extracted with methanol 70% by maceration. The water-soluble portion of the total hydroalcoholic extract was prepared with liquid-liquid extraction (LLE). Afterwards, the antioxidant activity, total phenolic and flavonoids content of the aqueous fraction were determined. In order to evaluate the effects of the aqueous fraction on cardiac parameters and I/R injury, the Langendroff method was used on Male Wistar rats...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28196619/development-and-verification-of-novel-porous-titanium-metaphyseal-cones-for-revision-total-knee-arthroplasty
#16
Ahmad Faizan, Manoshi Bhowmik-Stoker, Amanda E Kirk, Viktor E Krebs, Steven F Harwin, R Michael Meneghini
BACKGROUND: Porous metaphyseal cones are widely used in revision knee arthroplasty. A new system of porous titanium metaphyseal cones has been designed based on the femoral and tibial morphology derived from a computed tomography-based anatomical database. The purpose of this study is to evaluate the initial mechanical stability of the new porous titanium revision cone system by measuring the micromotion under physiologic loading compared with a widely-used existing porous tantalum metaphyseal cone system...
January 18, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28195849/detection-and-alterations-of-acetylcarnitine-in-human-skeletal-muscles-by-1h-mrs-at-7-t
#17
Radka Klepochová, Ladislav Valkovič, Martin Gajdošík, Thomas Hochwartner, Harald Tschan, Michael Krebs, Siegfried Trattnig, Martin Krššák
OBJECTIVES: The aims of this study were to detect the acetylcarnitine resonance line at 2.13 ppm in the human vastus lateralis and soleus muscles, assess T1 and T2 relaxation times, and investigate the diurnal and exercise-related changes in absolute concentration noninvasively, using proton magnetic resonance spectroscopy at 7 T. MATERIALS AND METHODS: All measurements were performed on a 7 T whole-body Magnetom MR system with a 28-channel knee coil. Five healthy, moderately trained volunteers participated in the assessment of the detectability, repeatability, and relaxation times of acetylcarnitine...
February 10, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28194548/investigation-of-intra-herd-spread-of-mycobacterium-caprae-in-cattle-by-generation-and-use-of-a-whole-genome-sequence
#18
S Broeckl, S Krebs, A Varadharajan, R K Straubinger, H Blum, M Buettner
Single nucleotide polymorphisms (SNPs) calculated from whole genome sequencing (WGS) are ideally suited to study evolutionary relationships of pathogens and their epidemiology. Mycobacterium caprae infections have been documented frequently in cattle and red deer along the Bavarian and Austrian Alps during the last decade. However, little is still known about the transmission within cattle holdings and possible alterations of the genomes of M. caprae during such events. The aim of this study was to study the molecular epidemiology of bovine tuberculosis (bTB) in selected herds based on isolate-specific genome-wide SNPs and to perform a phylogenetic network analysis...
February 13, 2017: Veterinary Research Communications
https://www.readbyqxmd.com/read/28187051/kinetics-of-plasma-biomarkers-of-inflammation-and-lung-injury-in-surgical-patients-with-or-without-postoperative-pulmonary-complications
#19
Ary Serpa Neto, Pedro P Z A Campos, Sabrine N T Hemmes, Lieuwe D Bos, Thomas Bluth, Marion Ferner, Andreas Güldner, Markus W Hollmann, Inmaculada India, Thomas Kiss, Rita Laufenberg-Feldmann, Juraj Sprung, Demet Sulemanji, Carmen Unzueta, Marcos F Vidal Melo, Toby N Weingarten, Anita M Tuip-de Boer, Paolo Pelosi, Marcelo Gama de Abreu, Marcus J Schultz
BACKGROUND: Postoperative pulmonary complications (PPCs) are common after major abdominal surgery. The kinetics of plasma biomarkers could improve identification of patients developing PPCs, but the kinetics may depend on intraoperative ventilator settings. OBJECTIVE: To test whether the kinetics of plasma biomarkers are capable of identifying patients who will develop PPCs, and whether the kinetics depend on the intraoperative level of positive end-expiratory pressure (PEEP)...
February 9, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28184185/promotility-action-of-the-probiotic-bifidobacterium-lactis-hn019-extract-compared-with-prucalopride-in-isolated-rat-large-intestine
#20
Julie E Dalziel, Rachel C Anderson, Jason S Peters, Amy T Lynch, Nick J Spencer, James Dekker, Nicole C Roy
Attention is increasingly being focussed on probiotics as potential agents to restore or improve gastrointestinal (GI) transit. Determining mechanism of action would support robust health claims. The probiotic bacterium Bifidobacterium lactis HN019 reduces transit time, but its mechanisms of action and effects on motility patterns are poorly understood. The aim of this study was to investigate changes in GI motility induced by an extract of HN019 on distinct patterns of colonic motility in isolated rat large intestine, compared with a known promotility modulator, prucalopride...
2017: Frontiers in Neuroscience
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