keyword
MENU ▼
Read by QxMD icon Read
search

Krebs

keyword
https://www.readbyqxmd.com/read/29346355/increasing-rates-of-people-identifying-as-transgender-presenting-to-endocrine-services-in-the-wellington-region
#1
John W Delahunt, Hayley J Denison, Dalice A Sim, Jemima J Bullock, Jeremy D Krebs
AIMS: Overseas clinics specialising in management of transgender people have noted a marked increase in the numbers of people requesting therapy in the last few years. No data has been presented for New Zealand. We therefore reviewed the number of transgender people seen in the Wellington Endocrine Service to assess if the pattern was similar and assess any potential problems for service delivery. METHODS: Using hospital records, we reviewed the new appointments of people who were referred for advice on gender reassignment and seen in the Wellington Endocrine Service from 1990 to 2016...
January 19, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29343522/polyol-pathway-links-glucose-metabolism-to-the-aggressiveness-of-cancer-cells
#2
Annemarie Schwab, Aarif Siddiqui, Maria Eleni Vazakidou, Francesca Napoli, Martin Böttcher, Bianca Menchicchi, Umar Raza, Özge Saatci, Angela M Krebs, Fulvia Ferrazzi, Ida Rapa, Katja Dettmer-Wilde, Maximilian J Waldner, Arif B Ekici, Suhail Ahmed Kabeer Rasheed, Dimitrios Mougiakakos, Peter J Oefner, Özgür Şahin, Marco Volante, Florian R Greten, Thomas Brabletz, Paolo Ceppi
Cancer cells alter their metabolism to support their malignant properties. In this study, we report that the glucose-transforming polyol pathway (PP) gene aldo-keto-reductase-1-member-B1 (AKR1B1) strongly correlates with epithelial-to-mesenchymal transition (EMT). This association was confirmed in samples from lung cancer patients and from an EMT-driven colon cancer mouse model with p53 deletion. In vitro, mesenchymal-like cancer cells showed increased AKR1B1 levels, and AKR1B1 knockdown was sufficient to revert EMT...
January 17, 2018: Cancer Research
https://www.readbyqxmd.com/read/29340780/health-related-quality-of-life-in-outpatients-with-schizophrenia-factors-that-determine-changes-over-time
#3
Cristina Domenech, Carlo Altamura, Corrado Bernasconi, Ricardo Corral, Helio Elkis, Jonathan Evans, Ashok Malla, Marie-Odile Krebs, Anna-Lena Nordstroem, Mathias Zink, Josep Maria Haro
PURPOSE: The objective of this study was to analyze the clinical factors associated with changes in HRQoL in outpatients with schizophrenia using both generic and condition-specific HRQoL scales. METHODS: Adult outpatients with schizophrenia at least 18 years of age who did not have an acute psychotic exacerbation in the 3 months prior to baseline were recruited. PANSS dimensions were calculated based on Lindenmayer et al.'s five factors. HRQoL data were assessed by patients using the Schizophrenia Quality of Life Scale (SQLS), the Short Form-36 (SF-36), and the EuroQol-5 Dimension (EQ-5D) questionnaires...
January 16, 2018: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29334765/examining-use-of-mobile-phones-for-sleep-tracking-among-a-national-sample-in-the-usa
#4
Rebecca Robbins, Paul Krebs, David M Rapoport, Girardin Jean-Louis, Dustin T Duncan
Mobile technology has been designed to serve a number of functions relating to health, but we know little about individuals who use these tools to track sleep. This study utilized data from a cross-sectional, geographically diverse survey of adults in the USA (N = 934). Among the sample, 28.2% (n = 263) report current use of a mobile phone for sleep tracking. Income and gender were significant correlates of sleep tracking (p < 0.05). Compared to a poor diet, a reported "excellent" diet was associated with sleep tracking (p < 0...
January 15, 2018: Health Communication
https://www.readbyqxmd.com/read/29332423/first-experiences-with-a-wearable-multisensor-in-an-outpatient-glucose-monitoring-study-part-i-the-users-view
#5
Andreas Caduff, Mattia Zanon, Pavel Zakharov, Martin Mueller, Mark Talary, Achim Krebs, Werner A Stahel, Marc Donath
BACKGROUND: Extensive past work showed that noninvasive continuous glucose monitoring with a wearable Multisensor device worn on the upper arm provides useful information about glucose trends to improve diabetes therapy in controlled and semicontrolled conditions. METHODS: To test previous findings also in uncontrolled in-clinic and outpatient conditions, a long-term study has been conducted to collect Multisensor and reference glucose data in a population of 20 type 1 diabetes subjects...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29330206/evolution-of-cytogenetically-normal-acute-myeloid-leukemia-during-therapy-and-relapse-an-exome-sequencing-study-of-50-patients
#6
Philipp A Greif, Luise Hartmann, Sebastian Vosberg, Sophie Stief, Raphael Mattes, Ines Hellmann, Klaus H Metzeler, Tobias Herold, Stefanos Bamopoulos, Paul Kerbs, Vindi Jurinovic, Daniela Schumacher, Friederike Pastore, Kathrin Bräundl, Evelyn Zellmeier, Bianka Ksienzyk, Nikola Konstandin, Stephanie Schneider, Alexander Graf, Stefan Krebs, Helmut Blum, Martin Neumann, Claudia Baldus, Stefan K Bohlander, Stephan Wolf, Dennis Goerlich, Wolfgang E Berdel, Bernhard J Woermann, Wolfgang Hiddemann, Karsten Spiekermann
PURPOSE: To study mechanisms of therapy-resistance and disease progression, we analyzed the evolution of cytogenetically normal acute myeloid leukemia (CN-AML) based on somatic alterations. EXPERIMENTAL DESIGN: We performed exome-sequencing of matched diagnosis, remission and relapse samples from 50 CN-AML patients treated with intensive chemotherapy. Mutation patterns were correlated with clinical parameters. RESULTS: Evolutionary patterns correlated with clinical outcome...
January 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29328966/cementum-as-a-source-of-dna-in-challenging-forensic-cases
#7
Hussam Mansour, Oliver Krebs, Jan Peter Sperhake, Christa Augustin, Till Koehne, Michael Amling, Klaus Püschel
Each forensic case is characterized by its own uniqueness. Deficient forensic cases require additional sources of human identifiers to assure the identity. We report on two different cases illustrating the role of teeth in answering challenging forensic questions. The first case involves identification of an adipocere male found in a car submersed in water for approximately 2 years. The second scenario, which involves paternity DNA testing of an exhumed body, was performed approximately 2.8 years post-mortem...
January 3, 2018: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29327286/abcd3-i-score-and-the-risk-of-early-or-3-month-stroke-recurrence-in-tissue-and-time-based-definitions-of-tia-and-minor-stroke
#8
Lukas Mayer, Julia Ferrari, Stefan Krebs, Christian Boehme, Thomas Toell, Benjamin Matosevic, Alexander Tinchon, Michael Brainin, Thomas Gattringer, Peter Sommer, Peter Thun, Johann Willeit, Wilfried Lang, Stefan Kiechl, Michael Knoflach
Changing definition of TIA from time to a tissue basis questions the validity of the well-established ABCD3-I risk score for recurrent ischemic cerebrovascular events. We analyzed patients with ischemic stroke with mild neurological symptoms arriving < 24 h after symptom onset in a phase where it is unclear, if the event turns out to be a TIA or minor stroke, in the prospective multi-center Austrian Stroke Unit Registry. Patients were retrospectively categorized according to a time-based (symptom duration below/above 24 h) and tissue-based (without/with corresponding brain lesion on CT or MRI) definition of TIA or minor stroke...
January 11, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29322584/effects-of-fixation-on-electrophysiology-and-structure-of-human-jejunal-villi
#9
Anna Casselbrant, Herbert F Helander
The villi of human jejunum vary in size and shape during different functional conditions. In the base the lamina propria is isotonic with blood, in the tip hyperosmotic. Here we study electrophysiological and morphological effects of incubation in hypotonic, isotonic, or hypertonic solutions, and to test various isotonic fixatives for microscopy. Samples of jejunal mucosae, obtained during surgery in obese patients, were studied in Ussing chambers where electrical parameters were registered during incubation in Krebs solution at various osmolarities, and during fixation in formaldehyde, glutaraldehyde, or osmium tetroxide (OsO4 )...
January 11, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29322245/interactions-between-incentive-valence-and-action-information-in-a-cued-approach-avoidance-task
#10
Vincent Hoofs, Thomas Carsten, C Nico Boehler, Ruth M Krebs
Environmental stimuli can provoke specific response tendencies depending on their incentive valence. While some studies report positive-approach and negative-avoidance biases, others find no such mappings. To further illuminate the relationship between incentive valence and action requirement, we combined a cued monetary incentive paradigm with an approach/avoidance joystick task. Incentive type was manipulated between groups: The reward group won money, while the punishment group avoided losing money for correct and fast responses to targets following incentive cues...
January 10, 2018: Psychological Research
https://www.readbyqxmd.com/read/29316025/impedance-spectroscopy-measurements-as-a-tool-for-distinguishing-different-luminal-content-during-bolus-transit-studies
#11
A Ruiz-Vargas, R Mohd Rosli, A Ivorra, J W Arkwright
BACKGROUND: Intraluminal electrical impedance is a well-known diagnostic tool used to study bolus movement in the human esophagus. However, it is use in the human colon it is hindered by the fact that the content cannot be controlled and may include liquid, gas, solid, or a mixture of these at any one time. This article investigates the use of complex impedance spectroscopy to study different luminal content (liquid and gas). METHODS: An excised section of guinea pig proximal colon was placed in an organ bath with Krebs solution at 37°C and a custom built bioimpedance catheter was placed in the lumen...
January 8, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29315969/effectiveness-of-interventions-to-decrease-image-ordering-for-low-back-pain-presentations-in-the-emergency-department-a-systematic-review
#12
Chaocheng Liu, Shashwat Desai, Lynette D Krebs, Scott W Kirkland, Diana Keto-Lambert, Brian H Rowe
BACKGROUND: Low back pain (LBP) is an extremely frequent reason for patients to present to an emergency department (ED). Despite evidence against the utility of imaging, simple and advanced imaging (i.e., computed tomography [CT], magnetic resonance imaging [MRI]) for patients with LBP has become increasingly frequent in the ED. The objective of this review was to identify and examine the effectiveness of interventions aimed at reducing image ordering in the ED for LBP patients. METHODS: A protocol was developed a priori, following the PRISMA guidelines, and registered with PROSPERO...
January 8, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29309377/the-effects-of-short-term-subnormothermic-perfusion-after-cold-preservation-on-liver-grafts-from-donors-after-cardiac-death-an-ex-vivo-rat-model
#13
Yuta Kakizaki, Shigehito Miyagi, Kenji Shimizu, Koji Miyazawa, Wataru Nakanishi, Kazuaki Tokodai, Yasuyuki Hara, Chikashi Nakanishi, Michiaki Unno, Takashi Kamei, Masafumi Goto, Susumu Satomi
BACKGROUND: We previously reported that short oxygenated warm perfusion before cold storage (CS) had improved the graft viability of rat livers from donors after cardiac death (DCD). In this study, we investigated the effectiveness of short-term oxygenated subnormothermic perfusion for different durations after CS in a rat DCD model. METHODS: We used an isolated perfused rat liver system. In Study 1: the grafts were retrieved from Wistar rats 30min after cardiac arrest (thoracotomy), preserved in CS for 6h, and perfused with oxygenated subnormothermic (20-25°C) Krebs-Henseleit buffer for different durations (0, 15, 30, 60, and 90min groups; n=5 in each)...
January 5, 2018: Transplantation
https://www.readbyqxmd.com/read/29306618/milrinone-induced-postconditioning-requires-activation-of-mitochondrial-ca2-sensitive-potassium-mbkca-channels
#14
Friederike Behmenburg, Lara Trefz, Marianne Dorsch, Martin Ströthoff, Alexander Mathes, Annika Raupach, André Heinen, Markus W Hollmann, Marc M Berger, Ragnar Huhn
OBJECTIVES: Cardioprotection by postconditioning requires activation of mitochondrial large-conductance Ca2+-sensitive potassium (mBKCa) channels. The involvement of these channels in milrinone-induced postconditioning is unknown. The authors determined whether cardioprotection by milrinone-induced postconditioning involves activation of mBKCa channels in the rat heart in vitro. DESIGN: Randomized, prospective, blinded laboratory investigation. SETTING: Experimental laboratory...
November 29, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29306342/the-effects-of-competition-on-premiums-using-united-healthcare-s-2015-entry-into-affordable-care-act-s-marketplaces-as-an-instrumental-variable
#15
Cagdas Agirdas, Robert J Krebs, Masato Yano
One goal of the Affordable Care Act is to increase insurance coverage by improving competition and lowering premiums. To facilitate this goal, the federal government enacted online marketplaces in the 395 rating areas spanning 34 states that chose not to establish their own state-run marketplaces. Few multivariate regression studies analyzing the effects of competition on premiums suffer from endogeneity, due to simultaneity and omitted variable biases. However, United Healthcare's decision to enter these marketplaces in 2015 provides the researcher with an opportunity to address this endogeneity problem...
January 8, 2018: Health Economics, Policy, and Law
https://www.readbyqxmd.com/read/29304333/tyrosine-1-of-rna-polymerase-ii-ctd-controls-global-termination-of-gene-transcription-in-mammals
#16
Nilay Shah, Muhammad Ahmad Maqbool, Yousra Yahia, Amal Zine El Aabidine, Cyril Esnault, Ignasi Forné, Tim-Michael Decker, David Martin, Roland Schüller, Stefan Krebs, Helmut Blum, Axel Imhof, Dirk Eick, Jean-Christophe Andrau
The carboxy-terminal domain (CTD) of RNA polymerase (Pol) II is composed of a repetition of YSPTSPS heptads and functions as a loading platform for protein complexes that regulate transcription, splicing, and maturation of RNAs. Here, we studied mammalian CTD mutants to analyze the function of tyrosine1 residues in the transcription cycle. Mutation of 3/4 of the tyrosine residues (YFFF mutant) resulted in a massive read-through transcription phenotype in the antisense direction of promoters as well as in the 3' direction several hundred kilobases downstream of genes...
January 4, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29303591/degradation-kinetics-during-oxygen-electrocatalysis-on-perovskite-based-surfaces-in-alkaline-media
#17
Daniel Bick, Tobias B Krebs, Dominik Kleimaier, Alexander F Zurhelle, Georgi T Staikov, Rainer Waser, Ilia Valov
Oxygen evolution reaction (OER) during alkaline water electrolysis is the bottleneck of water splitting. Perovskite materials have been particularly proposed as good and economically reasonable electrocatalysts for the OER, showing promises and advantages with respect to classic metallic electrodes. However, the degradation of perovskites during catalysis is limiting their service lifetime. Recently, the material BaCo0.98Ti0.02O3-δ:Co3O4 was shown to be electrocatalytically and chemically stable during water electrolysis even at industrially relevant conditions...
January 5, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29298158/weight-and-metabolic-outcomes-12-years-after-gastric-bypass
#18
LETTER
Richard W Carroll, Richard S Stubbs, Jeremy D Krebs
New England Journal of Medicine, Volume 378, Issue 1, Page 93-96, January 2018.
January 4, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29295634/the-need-to-calculate-target-glucose-levels-when-measuring-changes-in-insulin-sensitivity-during-interventions-for-individuals-with-type-2-diabetes
#19
Nor Azlan Othman, Paul D Docherty, Jeremy D Krebs, Damon A Bell, J Geoffrey Chase
BACKGROUND: Physiological models that are used with dynamic test data to assess insulin sensitivity (SI) assume that the metabolic target glucose concentration ( GTARGET) is equal to fasting glucose concentration ( G0). However, recent research has implied that irregularities in G0 in diabetes may cause erroneous SI values. This study quantifies the magnitude of these errors. METHODS: A clinically validated insulin/glucose model was used to calculate SI with the standard fasting assumption (SFA) G0 = GTARGET...
January 1, 2018: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/29295015/sensitivity-of-sexual-victimization-estimates-to-definitional-and-measurement-decisions
#20
Christopher Krebs, Christine Lindquist, Michael Planty, Lynn Langton, Marcus E Berzofsky, Nakisa Asefnia, Ashley Griggs, Bonnie Shook-Sa, Kimberly Enders
Self-report surveys are subject to measurement error associated with variation in the methodology employed. The current analysis uses data from the Campus Climate Survey Validation Study (CCSVS) to examine the impact that measurement decisions have on estimates. The findings demonstrate that asking victims to provide detailed information in an effort to properly place incidents in time and classify incidents by type resulted in relatively minor decreases in estimate magnitude. Ultimately, asking respondents to provide or confirm additional incident-level information for proper classification resulted in more complete information with very little impact on estimates...
November 1, 2017: Journal of Interpersonal Violence
keyword
keyword
24101
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"