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https://www.readbyqxmd.com/read/29775724/biological-activities-and-phytocompounds-of-northwest-algeria-ajuga-iva-l-extracts-partial-identification-of-the-antibacterial-fraction
#1
Saida Medjeldi, Lamjed Bouslama, Amina Benabdalla, Rim Essid, Soumaya Haou, Salem Elkahoui
The use of synthetic food additive and the appearance of antibiotic resistance are at the basis of important human health problems. The substitution of synthetic compounds with new natural substances extracted from plants or microorganisms is therefore the ideal solution to this scourge. The objective of this work was to evaluate the phyto-constituents (polyphenols, flavonoids and condensed tannins), and to test the biological activities (antioxidant, antibacterial and antiviral) of the Ajuga iva (L) aerial part extracts...
May 15, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29772523/mhc-b-haplotypes-impact-susceptibility-and-resistance-to-rsv-a-infection
#2
Vishwa Mohini Khare, Vishesh Kumar Saxena, Alka Tomar, Karam Pal Singh, Kunwar Bahadur Singh, Amit Kumar Tiwari
We investigated the impact of haplotype of major histocompatibility complex (MHC)-B on the outcome of infection of Synthetic Dam Line (SDL) broiler strain with Rous Sarcoma Virus (RSV). Genomic analysis of MHC-B haplotypes, revealed a total of 12 known standard haplotypes that constituted to twenty-five different genotypes and one new haplotype of 217 bp size, designated BX . The inoculation of RSV-A in SDL chicks resulted in the development of tumors of progressive or regressive phenotypes with varying tumor profile index (TPI)...
June 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/29771625/a-multifaceted-approach-to-rsv-vaccination
#3
Jorge C G Blanco, Marina S Boukhvalova, Trudy G Morrison, Stefanie N Vogel
Respiratory Syncytial Virus (RSV) is the leading cause of pneumonia and bronchiolitis in infants, resulting in significant morbidity and mortality worldwide. In addition, RSV infections occur throughout different ages, thus, maintaining the virus in circulation, and increasing health risk to more susceptible populations such as infants, the elderly, and the immunocompromised. To date, there is no vaccine approved to prevent RSV infection or minimize symptoms of infection. Current clinical trials for vaccines against RSV are being carried out in four very different populations...
May 17, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29769339/differential-responses-by-human-respiratory-epithelial-cell-lines-to-respiratory-syncytial-virus-reflect-distinct-patterns-of-infection-control
#4
Philippa Hillyer, Rachel Shepard, Megan Uehling, Mina Krenz, Faruk Sheikh, Kalyn R Thayer, Lei Huang, Lihan Yan, Debasis Panda, Cindy Luongo, Ursula J Buchholz, Peter L Collins, Raymond P Donnelly, Ronald L Rabin
RSV infects small foci of respiratory epithelial cells via infected droplets. Infection induces expression of types I and III interferons (IFNs) and pro-inflammatory cytokines, the balance of which may restrict viral replication and affect disease severity. We explored this balance by infecting two respiratory epithelial cell lines with low doses of recombinant RSV expressing green fluorescent protein (rgRSV). A549 cells were highly permissive whereas BEAS-2B cells restricted infection to individual cells or small foci...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29769281/a-comparison-of-the-xpert-flu-rsv-xc-and-xpress-flu-rsv-assays
#5
Elena B Popowitch, Melissa B Miller
Molecular diagnostics for influenza and respiratory syncytial virus (RSV) have become commonplace and a variety of tests and systems have been FDA-cleared for use in the United States. We performed a retrospective study to compare the Cepheid Xpress Flu/RSV assay to the Xpert Flu/RSV XC assay, using laboratory-developed tests (LDTs) as the reference method. The Xpress assay was 100% accurate as compared to the LDTs, while the Xpert Flu/RSV XC was 96.0% accurate. The Xpress test was determined to be faster and more sensitive than the XC...
May 16, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29765035/efficacy-of-a-respiratory-syncytial-virus-vaccine-candidate-in-a-maternal-immunization-model
#6
Jorge C G Blanco, Lioubov M Pletneva, Lori McGinnes-Cullen, Raymonde O Otoa, Mira C Patel, Lurds R Fernando, Marina S Boukhvalova, Trudy G Morrison
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in infants. Maternal immunization is an option to increase maternal antibody levels and protect infants from infection. Here we assess the efficacy of virus-like particle (VLP) vaccine candidates containing stabilized pre-fusion (pre-F) or post-fusion (post-F) conformations of the RSV F protein and the attachment RSV G protein in a maternal immunization model using cotton rats. VLP vaccines containing RSV F and G proteins strongly boost pre-existing RSV immunity in dams preventing their perinatal drop in immunity...
May 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29763837/different-meteorological-parameters-influence-metapneumovirus-and-respiratory-syncytial-virus-activity
#7
Magali Darniot, Cécile Pitoiset, Laurine Millière, Ludwig Serge Aho-Glélé, Emmanuel Florentin, Jean-Baptiste Bour, Catherine Manoha
BACKGROUND: Both human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) cause epidemics during the cold season in temperate climates. OBJECTIVES: The purpose of this study was to find out whether climatic factors are associated with RSV and hMPV epidemics. STUDY DESIGN: Our study was based on data from 4300 patients admitted to the Dijon University Hospital for acute respiratory infection (ARI) over three winter seasons chosen for their dissimilar meteorological and virological patterns...
May 5, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29758202/mounting-evidence-validates-ursolic-acid-directly-activates-sirt1-a-powerful-stac-which-mimic-endogenous-activator-of-sirt1
#8
Nuredin Bakhtiari, Sako Mirzaie, Roohullah Hemmati, Elham Moslemee-Jalalvand, Ali Reza Noori, Jahanfard Kazemi
Ursolic Acid (UA), a pentacyclic triterpenoid compound, plays a vital role in aging process. However, the role of UA in the regulation of aging and longevity is still controversial as we have previously demonstrated that UA increases SIRT1 protein level in aged-mice. Here, we reveal that UA directly activates SIRT1 in silico, in vitro and in vivo. We have identified that UA binds to outer surface of SIRT1 and leads to tight binding of substrates to enzyme in comparison with Resveratrol (RSV) and control. Furthermore, our results indicate that UA drives the structure of SIRT1 toward a closed state (an active form of enzyme)...
May 11, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29752339/resveratrol-enhances-matrix-biosynthesis-of-nucleus-pulposus-cells-through-activating-autophagy-via-the-pi3k-akt-pathway-under-oxidative-damage
#9
Jinlou Gao, Qingyun Zhang, Lin Song
BACKGROUND: The decrease in nucleus pulposus (NP) matrix production is a classic  feature during disc degeneration. Resveratrol (RSV) is reported to play protective effects under many pathological factors. OBJECTIVE: This study aims to study the effects of RSV on NP matrix homeostasis under oxidative damage and the potential mechanism. METHODS: Rat NP cells were exposed to H2 O2 solution to create an oxidative damage. RSV and the 3‑Methyladenine (3-MA) was added along with the culture medium to respectively investigate the role of RSV and cellular autophagy...
May 11, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29751747/a-fatal-case-associated-with-respiratory-syncytial-virus-infection-in-a-young-child
#10
Lili Xu, Hengmiao Gao, Jiansheng Zeng, Jun Liu, Cong Lu, Xiaolei Guan, Suyun Qian, Zhengde Xie
BACKGROUND: Respiratory syncytial virus (RSV) is the most common viral cause of pediatric bronchiolitis and pneumonia worldwide. Risk factors for high mortality and prolonged morbidity after RSV infection include premature birth, bronchopulmonary dysplasia, congenital heart disease, and Down syndrome. However, some previously healthy, full-term children who are infected with RSV also require hospitalization and even experience severe sequelae or death. CASE PRESENTATION: In this report, we present the case of an RSV-associated death of a child who was born at full-term and developed normally up to the age of 2 years old...
May 11, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29750895/predictors-and-incidence-of-hospitalization-due-to-respiratory-syncytial-virus-rsv-associated-lower-respiratory-tract-infection-lrti-in-non-prophylaxed-moderate-to-late-preterm-infants-in-bosnia-and-herzegovina
#11
Hajrija Maksić, Suada Heljić, Fahrija Skokić, Darinka Šumanović-Glamuzina, Veroslava Milošević, Almir Zlatanović, Notario Gerard
Prematurity is a risk factor for respiratory syncytial virus (RSV)-associated lower respiratory tract infections (LRTIs), due to immature humoral and cell-mediated immune system in preterm newborns, as well as their incomplete lung development. Palivizumab, a humanized monoclonal antibody against the F glycoprotein of RSV, is licensed for the prevention of severe RSV LRTI in children at high risk for the disease. This study is a part of a larger observational, retrospective-prospective epidemiological study (PONI) conducted at 72 sites across 23 countries in the northern temperate zone...
April 27, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29747463/thiol-activated-hydrogen-sulfide-donors-antiviral-and-anti-inflammatory-activity-in-respiratory-syncytial-virus-infection
#12
Nikolay Bazhanov, Teodora Ivanciuc, Haotian Wu, Matteo Garofalo, Jianming Kang, Ming Xian, Antonella Casola
We have recently shown that endogenous hydrogen sulfide (H₂S), an important cellular gaseous mediator, exerts an antiviral and anti-inflammatory activity in vitro and in vivo, and that exogenous H₂S delivered via the synthetic H₂S-releasing compound GYY4137 also has similar properties. In this study, we sought to extend our findings to a novel class of H₂S donors, thiol-activated gem-dithiol-based (TAGDDs). In an in vitro model of human respiratory syncytial virus (RSV) infection, TAGDD-1 treatment significantly reduced viral replication, even when added up to six hours after infection...
May 10, 2018: Viruses
https://www.readbyqxmd.com/read/29747393/anti-rsv-peptide-loaded-liposomes-for-the-inhibition-of-respiratory-syncytial-virus
#13
Sameer Joshi, Atul A Chaudhari, Vida Dennis, Daniel J Kirby, Yvonne Perrie, Shree Ram Singh
Although respiratory syncytial virus (RSV) is one of the leading causes of acute respiratory tract infection in infants and adults, effective treatment options remain limited. To circumvent this issue, there is a novel approach, namely, the development of multifunctional liposomes for the delivery of anti RSV-peptides. While most of the peptides that are used for loading with the particulate delivery systems are the penetrating peptides, an alternative approach is the development of liposome-peptide systems, which are loaded with an RSV fusion peptide (RF-482), which has been designed to inhibit the RSV fusion and block infection...
May 9, 2018: Bioengineering
https://www.readbyqxmd.com/read/29743773/first-reported-case-of-respiratory-syncytial-virus-infection-causing-guillain-barr%C3%A3-syndrome
#14
Scott A Helgeson, Alexander J Heckman, Dana M Harris
Acute immune-mediated polyneuropathies are a group of illnesses that cause paralysis following an infection. We describe a case of one of these illnesses being caused by the respiratory syncytial virus (RSV). An 81-year-old female was admitted for an RSV infection. She went into respiratory failure requiring intubation and mechanical ventilation and treatment with ribavirin. When she was extubated, she had bilateral lower extremity weakness and absent reflexes. Her disease progressed rapidly to involve her diaphragm, and eventually, the family agreed to let the natural death process occur...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29743373/five-residues-in-the-apical-loop-of-the-respiratory-syncytial-virus-fusion-protein-f-2-subunit-are-critical-for-its-fusion-activity
#15
Stephanie N Hicks, Supranee Chaiwatpongsakorn, Heather M Costello, Jason S McLellan, William Ray, Mark E Peeples
The respiratory syncytial virus (RSV) fusion (F) protein is a trimeric, membrane-anchored glycoprotein capable of mediating both viral-target cell membrane fusion to initiate infection and cell-cell fusion, even in the absence of the attachment glycoprotein. The F protein is initially expressed in a precursor form, whose functional capabilities are activated by proteolysis at two sites between the F1 and F2 subunits. This cleavage results in expression of the metastable and high-energy prefusion conformation...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29743346/pgd2-dp2-receptor-activation-promotes-severe-viral-bronchiolitis-by-suppressing-ifn-%C3%AE-production
#16
Rhiannon B Werder, Jason P Lynch, Jennifer C Simpson, Vivian Zhang, Nick H Hodge, Matthew Poh, Elizabeth Forbes-Blom, Christina Kulis, Mark L Smythe, John W Upham, Kirsten Spann, Mark L Everard, Simon Phipps
Prostaglandin D2 (PGD2) signals through PGD2 receptor 2 (DP2, also known as CRTH2) on type 2 effector cells to promote asthma pathogenesis; however, little is known about its role during respiratory syncytial virus (RSV) bronchiolitis, a major risk factor for asthma development. We show that RSV infection up-regulated hematopoietic prostaglandin D synthase expression and increased PGD2 release by cultured human primary airway epithelial cells (AECs). Moreover, PGD2 production was elevated in nasopharyngeal samples from young infants hospitalized with RSV bronchiolitis compared to healthy controls...
May 9, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29742646/burden-of-human-metapneumovirus-and-respiratory-syncytial-virus-infections-in-asthmatic-children
#17
Takashi Furuta, Shunji Hasegawa, Makoto Mizutani, Takashi Iwai, Noriko Ohbuchi, Shoji Kawano, Norimichi Tashiro, Masashi Uchida, Masanari Hasegawa, Masashi Motoyama, Takaomi Sekino, Kenji Nakatsuka, Kiyoshi Ichihara, Komei Shirabe, Shouichi Ohga
BACKGROUND: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory illness in children. Clinical burden of each infection on the respiratory distress in asthmatic patients remains unclear. The purpose of the study is to clarify the effect of these infections on the severity of asthmatic children in the seasonal outbreaks. METHODS: A total of 1,217 pediatric inpatients with hMPV (n=114) or RSV (n=1,103) infection in Yamaguchi prefecture, Japan between 2011 and 2014 were enrolled...
May 4, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29741642/a-cross-sectional-surveillance-study-of-the-frequency-and-etiology-of-acute-respiratory-illness-among-pregnant-women
#18
Anne M Hause, Vasanthi Avadhanula, Maurizio L Maccato, Phillip M Pinell, Nanette Bond, Patricia Santarcangelo, Laura Ferlic-Stark, Flor M Munoz, Pedro A Piedra
Background: Other than influenza, little is known about the consequences of viral acute respiratory illness (ARI) on pregnant women and fetuses. Our objectives were to determine the frequency of ARI due to respiratory viruses and the associated clinical outcomes during pregnancy. Methods: Pregnant women in their second or third trimester were enrolled if they reported having symptoms of ARI or were healthy within the preceding 2 weeks. Nasopharyngeal secretions were evaluated for respiratory viruses by molecular diagnostic assays...
May 5, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29740449/protective-role-of-nuclear-factor-erythroid-2-related-factor-2-against-respiratory-syncytial-virus-and-human-metapneumovirus-infections
#19
Teodora Ivanciuc, Elena Sbrana, Antonella Casola, Roberto P Garofalo
The pathogenesis of respiratory syncytial virus (RSV) infections is characterized by lower airway obstruction driven at great extent by the exuberant production of inflammatory cytokines. We have previously shown that RSV infection in vitro and in vivo results in production of reactive oxygen species along with reduction in the expression of antioxidant enzymes (AOEs), which are involved in maintaining the cellular oxidant-antioxidant balance. These events were associated with the concomitant reduction in nuclear factor erythroid 2-related factor 2 (Nrf2), a key transcription factor that controls AOE expression...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29737017/pediatric-acute-respiratory-distress-syndrome-associated-with-human-metapneumovirus-and-respiratory-syncytial-virus
#20
Thyyar M Ravindranath, Amanda Gomez, Ilana Harwayne-Gidansky, Thomas J Connors, Nathan Neill, Bruce Levin, Joy D Howell, Lisa Saiman, John S Baird
OBJECTIVES: To study the incidence, risk factors, clinical course, and outcome of ARDS in children with HMP and RSV. WORKING HYPOTHESIS: We hypothesized that ARDS in children with HMP was similar in incidence, risk factors, clinical course, and outcomes to ARDS in children with RSV. STUDY DESIGN: Retrospective, observational study over 2 years. PATIENT-SUBJECT SELECTION: Patients included were <18 years old with HMP or RSV detected from nasopharyngeal specimens by commercial reverse transcriptase polymerase chain reaction assay admitted to a study site...
May 7, 2018: Pediatric Pulmonology
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