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Spine metastasis

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https://www.readbyqxmd.com/read/27905158/metastatic-spinal-cord-compression-from-basal-cell-carcinoma-of-the-skin-treated-with-surgical-decompression-and-vismodegib-case-report-and-review-of-hedgehog-signalling-pathway-inhibition-in-advanced-basal-cell-carcinoma
#1
J McGrane, S Carswell, T Talbot
We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous)...
November 30, 2016: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27900552/giant-chordoma-in-the-thoracolumbar-spine-a-case-report-and-literature-review
#2
Feifei Pu, Baichuan Wang, Jianxiang Liu, Fengxia Chen, Zengwu Shao
STUDY DESIGN: Case report. PURPOSE: We present a rare case of a giant chordoma in the thoracolumbar spine and review the current literature. We describe its complicated clinical progression, hoping to shed light on the clinical management of this complex tumor. METHODS: We present a previously healthy 41-year-old man who experienced progressive low back pain at T10-L2 for the past 2 years. A giant tumor was detected on magnetic resonance imaging, and aspiration biopsy was used to obtain a definite pathological diagnosis...
November 29, 2016: European Spine Journal
https://www.readbyqxmd.com/read/27895769/unusual-lower-back-pain-with-monocytosis-a-case-report
#3
Sheng-Cheng Wu, Tzu-Chuan Huang, Wen-Ya Yu, Yi-Ying Wu
There are numerous causes of lower back pain. In the oncological setting, spine metastasis from a solid tumor is the most common. However, hematological disorders should also be taken into consideration. The current study presents a case of chronic myelomonocytic leukemia with the initial presentation of chronic lower back pain, followed by symptoms that included urinary retention, stool incontinence and left gum swelling, in a patient who was eventually diagnosed with granulocytic sarcoma (GS) over the sacral region...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27843032/volume-of-lytic-vertebral-body-metastatic-disease-quantified-using-computed-tomography-based-image-segmentation-predicts-fracture-risk-after-spine-stereotactic-body-radiation-therapy
#4
Isabelle Thibault, Cari M Whyne, Stephanie Zhou, Mikki Campbell, Eshetu G Atenafu, Sten Myrehaug, Hany Soliman, Young K Lee, Hamid Ebrahimi, Albert J M Yee, Arjun Sahgal
PURPOSE: To determine a threshold of vertebral body (VB) osteolytic or osteoblastic tumor involvement that would predict vertebral compression fracture (VCF) risk after stereotactic body radiation therapy (SBRT), using volumetric image-segmentation software. METHODS AND MATERIALS: A computational semiautomated skeletal metastasis segmentation process refined in our laboratory was applied to the pretreatment planning CT scan of 100 vertebral segments in 55 patients treated with spine SBRT...
September 28, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27819871/atypical-notochordal-cell-tumors-a-series-of-notochordal-derived-tumors-that-defy-current-classification-schemes
#5
Jodi M Carter, Doris E Wenger, Peter S Rose, Carrie Y Inwards
By the current WHO classification, benign notochordal cell tumor (BNCT) and chordoma comprise the entire spectrum of notochordal-derived tumors. They have defined radiologic and histologic criteria, and differ considerably in management and clinical outcome. Chordomas are malignant tumors; they show progressive, destructive growth and have the capacity for metastasis. In contrast, BNCT are benign and show limited intraosseous growth. Patients with BNCT can be managed with serial imaging or conservative excision, whereas patients with spinal/sacral chordomas typically undergo radical en bloc resection often with adjuvant therapy and significant morbidity...
November 4, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27807108/development-of-a-prognostic-survival-algorithm-for-patients-with-metastatic-spine-disease
#6
Nuno Rui Paulino Pereira, Stein J Janssen, Eva van Dijk, Mitchel B Harris, Francis J Hornicek, Marco L Ferrone, Joseph H Schwab
BACKGROUND: Current prognostication models for survival estimation in patients with metastatic spine disease lack accuracy. Identifying new risk factors could improve existing models. We assessed factors associated with survival in patients surgically treated for spine metastases, created a classic scoring algorithm, nomogram, and boosting algorithm, and tested the predictive accuracy of the three created algorithms at estimating survival. METHODS: We included 649 patients from two tertiary care referral centers in this retrospective study (2002 to 2014)...
November 2, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27790371/total-or-partial-vertebrectomy-for-lung-cancer-invading-the-spine
#7
Soichi Oka, Hiroki Matsumiya, Shuichi Shinohara, Taiji Kuwata, Masaru Takenaka, Yasuhiro Chikaishi, Ayako Hirai, Naoko Imanishi, Koji Kuroda, Sohsuke Yamada, Hidetaka Uramoto, Eiichiro Nakamura, Fumihiro Tanaka
BACKGROUND: Surgery for lung cancer invading the spine remains challenging associated with high morbidity and mortality. However, recent advances in surgical techniques as well as in perioperative care may improve outcomes of lung cancer surgery with vertebrectomy. We describe our surgical approach and assess the outcome lung cancer invading the spine. METHODS: We retrospectively reviewed our recent experiences of lung cancer with vertebral invasion, in which we have performed total or partial vertebrectomy from January 2011 through April 2015...
December 2016: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/27781486/quality-of-tri-co-60-mr-igrt-treatment-plans-in-comparison-with-vmat-treatment-plans-for-spine-sabr
#8
Chang Heon Choi, So-Yeon Park, Jung-In Kim, Jin Ho Kim, Kyubo Kim, Joel Carlson, Jong Min Park
OBJECTIVES: To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) plans for spine stereotactic ablative radiotherapy (SABR). METHODS: A total of 20 patients with spine metastasis were retrospectively selected. For each patient, a tri-Co-60 IMRT plan and a volumetric modulated arc therapy (VMAT) plan were generated. The spinal cords were defined based on magnetic resonance images for the tri-Co-60 IMRT, while isotropic 1 mm margins were added to the spinal cords for the VMAT plans...
October 26, 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27768024/our-experience-in-the-treatment-of-vertebral-metastases-from-renal-cell-carcinoma-a-retrospective-study
#9
Giulia R Mosele, Gianfilippo Caggiari, Roberto M Scarpa, Carlo Doria
BACKGROUND: Renal cell carcinoma (RCC) is among the 10 most common cancers in both men and women. It comprises 2-3% of all malignancies. The most common site for metastasis from RCC is the lung (50% of patients), followed by the skeleton (20% to 50% of patients). METHODS: We retrospectively reviewed our consecutive series of 63 patients surgically treated for spinal metastases from RCC. The surgical treatment for spinal metastases varied in each patient. Factors influencing the choice of surgery included age, disease status, symptoms, morbidity of the patient, the location, the number of repetitive lesions and the existence of extra-osseous metastases...
October 21, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27765548/metastasis-of-mammary-gland-malignant-phyllodes-tumor-to-the-mandibular-region-a-case-report-and-review-of-the-literature
#10
Sayaka Yoshiba, Takashi Saotome, Tetsuya Mikogami, Tatsuo Shirota
Phyllodes tumor is a rare breast tumor described by Müller (1938) as a lesion comprising leaflike stromal fibrous components and narrow cysts. The frequency of distant metastasis from this entity is reportedly approximately 20%, and no effective therapy has been established, so the prognosis is poor. This report describes the case of a 60-year-old woman with a history of left lung resection who showed metastasis of a mammary gland malignant phyllodes tumor to the oral cavity. Intraoral examination showed an elastic, hard mass measuring 28 × 27 mm in the gingiva around the left mandibular second molar...
September 23, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27764719/leptomeningeal-metastasis-from-gynecologic-cancers-diagnosed-by-brain-mri
#11
Masafumi Toyoshima, Keita Tsuji, Shogo Shigeta, Hideki Tokunaga, Kiyoshi Ito, Yoh Watanabe, Kosuke Yoshinaga, Takeo Otsuki, Hitoshi Niikura, Nobuo Yaegashi
Leptomeningeal metastasis (LM) is rarely observed in gynecologic cancers. As gadolinium-enhanced magnetic resonance imaging (Gd-MRI) is highly effective for diagnosing LM, the aim of this study is to describe the clinical behaviors and outcomes of LM patients who were diagnosed by Gd-MRI. After securing institutional review board approvals, we retrospectively reviewed patient records. Eight patients were found to have LM from gynecological malignancies. Primary tumors included three ovarian cancers, one tubal cancer, one peritoneal cancer, two endometrial cancers, and one cervical cancer...
September 30, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27764058/prospective-cohort-study-of-performance-status-and-activities-of-daily-living-after-surgery-for-spinal-metastasis
#12
Kenichiro Kakutani, Yoshitada Sakai, Koichiro Maeno, Toru Takada, Takashi Yurube, Takuto Kurakawa, Shingo Miyazaki, Yoshiki Terashima, Masaaki Ito, Hitomi Hara, Teruya Kawamoto, Yasuo Ejima, Akihiro Sakashita, Naomi Kiyota, Yoshiyuki Kizawa, Ryohei Sasaki, Toshihro Akisue, Hironobu Minami, Ryosuke Kuroda, Masahiro Kurosaka, Kotaro Nishida
STUDY DESIGN: A prospective cohort study of performance status (PS) and activities of daily living (ADL) in patients with spinal metastasis. OBJECTIVE: To identify the effect of spinal surgery on PS and ADL in patients with spinal metastasis. SUMMARY OF BACKGROUND DATA: Spinal metastasis causes severe neurological deficits, resulting in drastic loss of patients' PS and ADL. However, the effect of spine surgery on PS and ADL is not well known...
October 19, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27752884/factors-affecting-survival-outcomes-of-patients-with-non-metastatic-ewing-s-sarcoma-family-tumors-in-the-spine-a-retrospective-analysis-of-63-patients-in-a-single-center
#13
Wei Wan, Yan Lou, Zhiqi Hu, Ting Wang, Jinsong Li, Yu Tang, Zhipeng Wu, Leqin Xu, Xinghai Yang, Dianwen Song, Jianru Xiao
Little information has been published in the literature regarding survival outcomes of patients with Ewing's sarcoma family tumors (ESFTs) of the spine. The purpose of this study is to explore factors that may affect the prognosis of patients with non-metastatic spinal ESFTs. A retrospective analysis of survival outcomes was performed in patients with non-metastatic spinal ESFTs. Univariate and multivariate analyses were employed to identify prognostic factors for recurrence and survival. Recurrence-free survival (RFS) and overall survival (OS) were defined as the date of surgery to the date of local relapse and death...
October 17, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27704262/risk-factors-for-same-admission-mortality-after-pathologic-fracture-secondary-to-metastatic-cancer
#14
Nicole K Behnke, Dustin K Baker, Shin Xu, Thomas E Niemeier, Shawna L Watson, Brent A Ponce
PURPOSE: The skeleton is the third most common site of cancer metastases. Approximately 10 % of patients with bone metastases will develop a pathologic fracture, with significant associated morbidity and mortality. The purpose of this study was to identify risk factors for same-admission mortality after pathologic fractures secondary to metastatic cancer. METHODS: The Nationwide Inpatient Sample database was queried from 2002 to 2013 for hospitalized patients with diagnoses of pathologic fracture and a primary cancer at high risk for skeletal metastasis...
October 4, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27703825/solitary-spinal-epidural-metastasis-from-gastric-cancer
#15
Taisei Sako, Yasuaki Iida, Yuichirou Yokoyama, Shintaro Tsuge, Keiji Hasegawa, Akihito Wada, Tetsuo Mikami, Hiroshi Takahashi
Solitary epidural space metastasis of a malignant tumor is rare. We encountered a 79-year-old male patient with solitary metastatic epidural tumor who developed paraplegia and dysuria. The patient had undergone total gastrectomy for gastric cancer followed by chemotherapy 8 months priorly. The whole body was examined for suspected metastatic spinal tumor, but no metastases of the spine or important organs were observed, and a solitary mass was present in the thoracic spinal epidural space. The mass was excised for diagnosis and treatment and was histopathologically diagnosed as metastasis from gastric cancer...
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27686468/diagnostic-utility-of-a-computer-aided-diagnosis-system-for-whole-body-bone-scintigraphy-to-detect-bone-metastasis-in-breast-cancer-patients
#16
Misugi Urano, Yumi Maki, Hiroko Nishikawa, Tatsuya Kawai, Norio Shiraki, Yuta Shibamoto
OBJECTIVE: To compare the diagnostic ability of planar images (PI) and images obtained by a computer-aided diagnosis (CAD) system (Viewer for Standardized Bone Scintigraphies; VSBONE) of whole-body bone scintigraphy for detecting bone metastases in breast cancer patients. METHODS: 81 women (median: 56 years; range: 32-79) with a history of breast cancer were included in this study. They underwent whole-body bone scintigraphy after intravenous injection of 740 MBq technetium-99m hydroxymethylene diphosphonate...
September 29, 2016: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/27683556/immunogenomics-of-hypermutated-glioblastoma-a-patient-with-germline-pole-deficiency-treated-with-checkpoint-blockade-immunotherapy
#17
Tanner M Johanns, Christopher A Miller, Ian G Dorward, Christina Tsien, Edward Chang, Arie Perry, Ravindra Uppaluri, Cole Ferguson, Robert E Schmidt, Sonika Dahiya, George Ansstas, Elaine R Mardis, Gavin P Dunn
We present the case of a patient with a left frontal glioblastoma with PNET features and hypermutated genotype in the setting of a POLE germline alteration. During standard-of-care chemoradiation, the patient developed a cervical spine metastasis and was subsequently treated with Pembrolizumab. Shortly thereafter, the patient developed an additional metastatic spinal lesion. Using whole exome DNA sequencing and clonal analysis, we report changes in the subclonal architecture throughout treatment. Furthermore, a persistently high neoantigen load was observed within all tumors...
September 28, 2016: Cancer Discovery
https://www.readbyqxmd.com/read/27675770/predicting-survival-of-patients-with-spine-metastasis-using-the-recursive-partitioning-analysis-rpa
#18
A Walker, S Mongoue-Tchkote, C Dai Kubicky
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675643/recursive-partitioning-analysis-is-predictive-of-overall-survival-for-patients-undergoing-spine-radiosurgery-for-spine-metastasis
#19
E H Balagamwala, J A Miller, C A Reddy, L Angelov, J H Suh, M B Tariq, K Yang, T Djemil, A Magnelli, A M Mohammadi, S Soeder, S T Chao
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675329/passively-scattered-proton-stereotactic-body-radiation-therapy-for-spine-metastasis-a-dosimetric-analysis
#20
I MacEwan, B Chou, R Mifflin, A Wroe, D A Bush
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
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