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Spine metastasis

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https://www.readbyqxmd.com/read/28819870/surgical-complications-of-extraspinal-tumors-in-the-cervical-spine-a-report-of-110-cases-and-literature-review
#1
WenHua Yang, Liang Jiang, XiaoGuang Liu, Feng Wei, Miao Yu, FengLiang Wu, Lei Dang, Hua Zhou, Hua Zhang, ZhongJun Liu
PURPOSE: To assess the safety of surgical intervention for extraspinal tumors in the cervical spine. METHODS: 110 consecutive patients were enrolled and followed-up at least 12 months or until death. The complication rates and risk factors were documented and analyzed. RESULTS: The quality of life in the surviving patients was significantly improved. The overall local recurrence rate was 17.3%. Twenty percent of patients developed distant metastasis...
August 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28808607/surgically-treated-spinal-metastases-do-prognostic-scores-have-a-role
#2
Afifa Afsar, Mohsin Qadeer, Salman Sharif
BACKGROUND: The outcome for patients with metastatic disease in spine is difficult to predict. Multiple scoring systems were utilized in this study to determine their effectiveness in predicting long-term prognoses. METHODS: A retrospective analysis of surgically treated patients of spinal metastasis was performed between 2005 and 2016. Data were collected prospectively during which 8 patients were lost to follow-up. Ultimately, data from 63 patients were reviewed...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28807628/vertebral-alveolar-echinococcosis-a-case-report-systematic-analysis-and-review-of-the-literature
#3
REVIEW
Thomas Raphael Meinel, Bruno Gottstein, Vanessa Geib, Marius Johann Keel, Ruggero Biral, Markus Mohaupt, Jan Brügger
Alveolar echinococcosis caused by Echinococcus multilocularis is an infrequent zoonosis with a high degree of disability, morbidity, and mortality, especially in disease clusters of the northern hemisphere. The diagnosis is complicated by extended incubation time, diverse clinical manifestations, and mimicking of differential diagnoses. The primary organ affected is the liver, but extrahepatic disease is possible, with vertebral involvement in only a few dozen cases described worldwide. Although vertebral alveolar echinococcosis seems to be rare, it might be under diagnosed, and it might be seen more often as the number of people with immunocompromised conditions increases...
August 11, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28803168/metastatic-cardiac-angiosarcoma-to-the-lung-spine-and-brain-a-case-report-and-review-of-the-literature
#4
Chih-Ta Lin, Katrina Ducis, Suzanne Tucker, Bruce Tranmer
BACKGROUND: Metastatic angiosarcoma to the brain is a rare entity without an established management protocol. CASE DESCRIPTION: The authors describe a case of primary cardiac angiosarcoma with a rare brain metastasis in an adult. This patient underwent successful resection of his brain metastasis and was initiated on only chemotherapy for his systemic disease. The patient did not develop local recurrence. A review of primary and metastatic CNS angiosarcoma, its pathologic features, clinical disease course, treatment strategies and genomics is also described...
August 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28758043/multiple-acrometastases-in-a-patient-with-renal-pelvic-urothelial-cancer
#5
Ryoko Sawada, Yusuke Shinoda, Aya Niimi, Tohru Nakagawa, Masachika Ikegami, Hiroshi Kobayashi, Sakae Tanaka, Yukio Homma, Nobuhiko Haga
Metastasis may occur in any bone but more commonly occurs in the spine, pelvis, or other axial bones. Metastasis in peripheral bones located distal to the elbow or knee, so-called acrometastasis, is rare. Although the mechanism of acrometastasis development is not completely understood, it is thought to be the result of a massive dissemination of cancer cells; thus the prognosis of patients with acrometastasis is relatively poor. Here, we report the case of renal pelvic cancer with multiple acrometastases in both the upper and lower extremities without axial bone metastasis in a 68-year-old man...
2017: Case Reports in Urology
https://www.readbyqxmd.com/read/28741325/continuous-pain-and-swelling-after-humerus-fracture-in-an-86-years-old-woman
#6
M Herrera-Pérez, J Boluda-Mengod, R Muñoz-Ortus, M J Gutiérrez-Morales, J Pais-Brito
Metastases to bone are the most frequent cause of destructive lesions to the skeleton in adults . The tumours that are most likely to metastasize to bone are prostate (32%), breast (22%), kidney (16%), lung and thyroid. The typical distribution of metastatic lesions are to the spine, ribs, pelvis, and proximal limb girdles. The humerus is the second most common site for long bone metastases, behind only the femur in its frequency of involvement . It represents the 20% of all bony metastases. We present a clinical case of an 86 yo woman with a previous diagnosis of myofibroblastic sarcoma of the maxillaris who suffers a pathological fracture of the humeral shaft secondary to metastasis and was misdiagnosed and treated for a typical humeral fracture using and intramedullary pinning (Hackethal technique), producing the progression of the disease within the humeral shaft...
January 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28740742/radical-surgery-of-only-the-anterior-elements-of-the-spine-at-the-posterior-element-fusion-level-due-to-metastatic-thyroid-cancer
#7
Ryuto Tsuchiya, Kazuki Fujimoto, Kazuhide Inage, Sumihisa Orita, Yasuhiro Shiga, Hiroto Kamoda, Kazuyo Yamauchi, Miyako Suzuki, Jun Sato, Koki Abe, Hirohito Kanamoto, Masahiro Inoue, Hideyuki Kinoshita, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Junichi Nakamura, Kazuhisa Takahashi, Seiji Ohtori
Spinal metastasis of differentiated thyroid cancer can have a favorable prognosis if radical surgery is performed. We encountered a case of spinal metastasis involving three anterior vertebral bodies at the posterior element fusion level and successfully achieved adequate stability by radical surgery involving only the anterior elements. A 67-year-old woman who had numbness and muscle weakness in the lower limbs caused by metastatic spinal tumor at the posterior element fusion level of L1-L3 vertebrae was treated with radical surgery of only the anterior element to gain stability...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28739923/therapeutically-targeting-glypican-2-via-single-domain-antibody-based-chimeric-antigen-receptors-and-immunotoxins-in-neuroblastoma
#8
Nan Li, Haiying Fu, Stephen M Hewitt, Dimiter S Dimitrov, Mitchell Ho
Neuroblastoma is a childhood cancer that is fatal in almost half of patients despite intense multimodality treatment. This cancer is derived from neuroendocrine tissue located in the sympathetic nervous system. Glypican-2 (GPC2) is a cell surface heparan sulfate proteoglycan that is important for neuronal cell adhesion and neurite outgrowth. In this study, we find that GPC2 protein is highly expressed in about half of neuroblastoma cases and that high GPC2 expression correlates with poor overall survival compared with patients with low GPC2 expression...
July 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28737577/vertebral-myeloma-mimicking-prostatic-carcinoma-metastasis-in-68ga-psma-pet-ct
#9
Esben Hoej Merrild, Steen Baerentzen, Kirsten Bouchelouche, Simon Buus
Ga-PSMA PET/CT was performed in a 75-year-old man with newly diagnosed prostate cancer because of an equivocal lesion in the spine both on Tc-bone-SPECT/CT and MRI. Because of increased PSMA activity on PET/CT, the bone lesion was interpreted as metastasis from prostate cancer. Later, the patient was diagnosed as having monoclonal gammopathy of unknown significance. A biopsy was performed, and histological examination revealed multiple myeloma with PSMA expression in the neovessels but no metastatic prostate cancer cells...
July 22, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28734793/hardware-failure-in-patients-with-metastatic-cancer-to-the-spine
#10
Rachel Pedreira, Nancy Abu-Bonsrah, A Karim Ahmed, Rafael De la Garza-Ramos, C Rory Goodwin, Ziya L Gokaslan, Justin Sacks, Daniel M Sciubba
BACKGROUND: The spine is the most common site of skeletal metastases, affecting approximately 30% of individuals with cancer. The aim of surgical treatment for metastatic spine disease is generally palliative to address pain and/or neurologic compromise, significantly improving patients' quality of life. Patients with metastatic spine disease, however, represent a vulnerable cohort and may have comorbidities or previous treatments that impair the structural integrity of spinal hardware...
July 19, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28731393/the-impact-of-decompression-with-instrumentation-on-local-failure-following-spine-stereotactic-radiosurgery
#11
Jacob A Miller, Ehsan H Balagamwala, Camille A Berriochoa, Lilyana Angelov, John H Suh, Edward C Benzel, Alireza M Mohammadi, Todd Emch, Anthony Magnelli, Andrew Godley, Peng Qi, Samuel T Chao
OBJECTIVE Spine stereotactic radiosurgery (SRS) is a safe and effective treatment for spinal metastases. However, it is unknown whether this highly conformal radiation technique is suitable at instrumented sites given the potential for microscopic disease seeding. The authors hypothesized that spinal decompression with instrumentation is not associated with increased local failure (LF) following SRS. METHODS A 2:1 propensity-matched retrospective cohort study of patients undergoing SRS for spinal metastasis was conducted...
July 21, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28704910/late-developing-metastatic-malignant-melanoma-in-the-thoracic-spine-originating-from-choroidal-melanoma
#12
Jun Kyu Hwang, Kyung Hyun Kim, Ji Sup Kim, Sung Jun Ahn, Sung Uk Kuh
A 54-year-old woman visited Gangnam Severance Hospital for left side flank pain. She had a history of total removal of malignant melanoma on the left eye ball 20 years prior. No evaluation had been performed since then. A paravertebral mass at thoracic ninth level (T9) was discovered on spinal magnetic resonance imaging, and pathology confirmed malignant melanoma. Following positron emission tomography-computed tomography, no other metastasis was discovered. After removal of the paravertebral mass, palliative chemotherapy (dacabarzine + tamoxifene) was administered in 3 cycles over 2 months...
June 2017: Korean Journal of Spine
https://www.readbyqxmd.com/read/28704338/analysis-of-metastatic-involvement-in-bone-using-anatomical-and-functional-information-from-18f-fdg-pet-ct
#13
Omer Demirkaya, Mohammed AlQahtani, Abdulaziz Alsugair, Omer Aras, Mohei-Eldin Abouzied
PURPOSE: Although the overall incidence of bone metastasis is not known, over one-half of the people who die of cancer in the USA every year are thought to have bone involvement. In this study we have developed a method to quantify the metabolic and anatomic changes induced by different types of bone metastases in cancer patients using PET/CT images. PATIENTS AND MATERIALS: Seventy-three cancer patients with no previous history of chemotherapy or radiotherapy who had definite bone metastases documented by PET/CT and other conventional modalities were selected for this study...
July 12, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28693153/clinical-outcome-of-brain-metastases-differs-significantly-among-breast-cancer-subtypes
#14
Nadja E Oehrlich, Loukia M Spineli, Frank Papendorf, Tjoung-Won Park-Simon
Brain metastases in patients with breast cancer are associated with a poor survival rate. A small number of studies have challenged this premise, suggesting that survival times following brain metastasis differ significantly between breast cancer subtypes. In the current study, overall survival (OS), brain metastases-free survival (BMFS) and survival following brain metastases (SFBM) were found to be associated with the intrinsic breast cancer subtype. A total of 1,147 patients with invasive breast cancer who were treated at the Hannover Medical School between January 2004 and December 2010 were included, from which 54 patients with brain metastases were identified...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28690908/primary-occipital-ewing-s-sarcoma-with-subsequent-spinal-seeding
#15
Ali Alqahtani, Roaa Amer, Eman Bakhsh
Ewing's sarcoma is a primary bone cancer that mainly affects the long bones. This malignancy is particularly common in pediatric patients. Primary cranial involvement accounts for 1% of cases, with occipital involvement considered extremely rare. In this case study, primary occipital Ewing's sarcoma with a posterior fossa mass and subsequent relapse resulting in spinal seeding is reported. A 3-year-old patient presented with a 1-year history of left-sided headaches, localized over the occipital bone with progressive torticollis...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28684728/a-rare-case-of-sarcomatoid-carcinoma-of-the-lung-with-spine-metastasis-including-a-literature-review
#16
Hafiza Sobia Arshad, Rizwan Ahmed Dudekula, Masooma Niazi, Sandeep Malik, Misbahuddin Khaja
BACKGROUND Sarcomatoid carcinoma is a rare, aggressive, malignant cancer composed of sarcoma and sarcoma-like components, and can occur in different organs such as the thyroid gland, bone, skin, breast, pancreas, liver, urinary tract, and lung. Pulmonary sarcomatoid carcinoma accounts for only a small percentage of lung cancers and has histological variants that include pleomorphic carcinoma, giant cell carcinoma, spindle cell carcinoma, carcinosarcoma, and pulmonary blastoma. CASE REPORT Here, we present a case of sarcomatoid carcinoma in a 63-year-old HIV-positive Hispanic male who presented with back pain, dry cough, and weight loss...
July 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28674582/intramedullary-spinal-cord-metastasis-from-laryngeal-carcinoma-case-report-and-review-of-literature
#17
REVIEW
Mohamed Sahli, Bouchaib Hemmaoui, Fouad Benariba
Laryngeal cancer metastases are relatively rare and mainly affect the lung. The medullary localization remains exceptional. We report the case of a patient followed for operated laryngeal cancer and whose oncologic control revealed a medullary localization. A patient followed for squamous cell carcinoma of the larynx, treated in 2010 by a partial surgery whose endoscopic control at 5 years revealed the presence of right arytenoid edema without suspicious lesions, multiple biopsies were made and which returned negative...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28670176/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-imaging-of-metastatic-nasopharyngeal-cancer-with-emphasis-on-the-distribution-of-bone-metastases
#18
Ammad Shanoon Al Tamimi, Sumbul Zaheer, David Chee Ng, Saabry Osmany
Distant metastases change the prognosis of patients with nasopharyngeal carcinoma (NPC) which most commonly metastasizes to the bone. (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography/computed tomography (PET/CT) is reported as useful in imaging NPC metastases. Our study assesses the incidence and distribution of bone metastases detected by (18)F-FDG PET/CT in NPC. 717 (18)F-FDG PET/CT scan reports of histologically proven NPC patients imaged in Singapore General Hospital, Singapore, between 2003 and 2009 were reviewed for the total number of metastases (scanned from vertex to mid-thigh) and analyzed for distribution...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28670075/malignant-thymoma-with-metastasis-associated-with-paraneoplastic-myasthenia-gravis
#19
Hourossadat Hashemi Jazi, David M Harmon, Tuan Tran, Claude Denham
We describe a patient who initially presented with a mixed thymic tumor and developed myasthenia gravis 8 years following thymectomy with recurrence of metastatic disease. Metastasis to the pleura, mediastinum, and cervical spine was identified with a positron emission tomography scan when this patient presented with recurring pneumonias and atrial fibrillation. The presentation and diagnosis were clouded by multiple courses of prednisone and chemotherapy for respiratory complications and metastatic disease, respectively...
July 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28663407/quality-of-life-after-resection-of-a-chordoma-of-the-mobile-spine
#20
J H Schwab, S J Janssen, N R Paulino Pereira, Y L E Chen, J C Wain, T F DeLaney, F J Hornicek
AIMS: The aim of the study was to compare measures of the quality of life (QOL) after resection of a chordoma of the mobile spine with the national averages in the United States and to assess which factors influenced the QOL, symptoms of anxiety and depression, and coping with pain post-operatively in these patients. PATIENTS AND METHODS: A total of 48 consecutive patients who underwent resection of a primary or recurrent chordoma of the mobile spine between 2000 and 2015 were included...
July 2017: Bone & Joint Journal
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