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https://www.readbyqxmd.com/read/30220042/chordoma-a-systematic-review-of-the-epidemiology-and-clinical-prognostic-factors-predicting-progression-free-and-overall-survival
#1
REVIEW
S H Bakker, W C H Jacobs, W Pondaag, H Gelderblom, R A Nout, P D S Dijkstra, W C Peul, C L A Vleggeert-Lankamp
BACKGROUND AND AIMS: The aim of this systematic review is to describe the epidemiology of chordoma and to provide a clear overview of clinical prognostic factors predicting progression-free and overall survival. METHODS: Four databases of medical literature were searched. Separate searches were performed for each of the two objectives. Reference and citation tracking was performed. Papers were processed by two independent reviewers according to a protocol that included risk of bias analysis...
September 15, 2018: European Spine Journal
https://www.readbyqxmd.com/read/30213164/anterolateral-cervical-kyphoplasty-for-metastatic-cervical-spine-lesions
#2
Amer Sebaaly, Ahmed Najjar, Zhi Wang, Ghassan Boubez, Laura Masucci, Daniel Shedid
STUDY DESIGN: Retrospective case series. PURPOSE: To evaluate the clinical and radiological efficacy of anterolateral kyphoplasty for cervical spinal metastasis. OVERVIEW OF LITERATURE: Although the spine is the third most common site of tumor metastasis, the cervical spine is the least commonly affected (incidence, 10%-15%). Surgical decompression is highly challenging because of the proximity of neural and vascular elements. Kyphoplasty for cervical spine metastasis has been described in small case reports with promising results...
October 2018: Asian Spine Journal
https://www.readbyqxmd.com/read/30210905/morphometrics-predicts-overall-survival-in-patients-with-multiple-myeloma-spine-metastasis-a-retrospective-cohort-study
#3
Hesham Mostafa Zakaria, Erinma Elibe, Mohammad Macki, Richard Smith, David Boyce-Fappiano, Ian Lee, Brent Griffith, Farzan Siddiqui, Victor Chang
Background: Treatment strategies for spinal metastases for myeloma range from conservative measures (radiation and chemotherapy) to invasive (surgical). Identifying better predictors of overall survival (OS) would help in surgical decision making. Analytic morphometrics has been shown to predict survival in oncologic patients, and our study evaluates whether morphometrics is predictive of survival in patients with multiple myeloma (MM) spinal metastases. Methods: For this observational retrospective cohort study, we identified 46 patients with MM spinal metastases who had undergone stereotactic body radiation therapy...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/30186136/a-case-of-vanishing-metastatic-mass-right-atrial-mass-in-the-setting-of-primary-epithelioid-hemangioendothelioma-of-the-spine
#4
Eshan Patel, P Kancharla, B K Surapaneni, K Hennrick, M Goldfinger, M Kalavar
Epithelioid hemangioendothelioma (EHE) is a rare low-grade vascular neoplasm that is characterized as intermediate between benign hemangioma and high-grade angiosarcoma affecting 1 in 1,000,000 people worldwide. It has been described throughout the body with lung, liver, skin, and bone being the most frequent sites. Primary EHE of the spine has been reported in 56 cases so far with no correlation of age and sex. Our case highlights a rare clinical presentation, etiopathogenesis, diagnosis, and treatment of EHE of the spine with metastasis to the right atrium...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/30172640/nationwide-comparative-study-of-synchronous-and-metachronous-spine-metastasis-in-the-adult-korean-population
#5
Seil Sohn, Chun Kee Chung, Jin Hyung Jung, Kyung Chul Lee, Jinhee Kim, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
This nationwide study of the adult Korean population aimed to compare the survival period between synchronous and metachronous group and to determine recent treatment trends in newly diagnosed spine metastasis patients. Data were extracted from the Korean Health Insurance Review and Assessment Service database. Patients in this study were newly diagnosed with metastatic spine tumors between July 1, 2011 and June 31, 2014. The metachronous group was defined when the primary tumor was diagnosed prior to the diagnosis of spine metastasis, otherwise patients were considered to be the part of the synchronous group...
August 29, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/30149806/surgical-management-and-outcome-of-synovial-sarcoma-in-the-spine
#6
Minglei Yang, Nanzhe Zhong, Chenglong Zhao, Wei Xu, Shaohui He, Jian Zhao, Xinghai Yang, Jianru Xiao
BACKGROUND: Synovial sarcoma (SS) is a soft tissue sarcoma that rarely occurs in the spine, and a minimal number of cases have been reported in the literature. Spinal SS is challenging in diagnosis and treatment and has a poor prognosis. The aim of this study was to summarize and analyse the clinical features and outcomes of patients with spinal SS. METHODS: A total of 16 cases of patients with spinal SS admitted to our institution were reviewed retrospectively...
August 27, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30134523/nanoporous-3d-printed-scaffolds-for-local-doxorubicin-delivery-in-bone-metastases-secondary-to-prostate-cancer
#7
Pouyan Ahangar, Elie Akoury, Ana Sofia Ramirez Garcia Luna, Antone Nour, Michael H Weber, Derek H Rosenzweig
The spine is the most common site of bone metastasis, often originating from prostate, lung, and breast cancers. High systemic doses of chemotherapeutics such as doxorubicin (DOX), cisplatin, or paclitaxel often have severe side effects. Surgical removal of spine metastases also leaves large defects which cannot spontaneously heal and require bone grafting. To circumvent these issues, we designed an approach for local chemotherapeutic delivery within 3D-printed scaffolds which could also potentially serve as a bone substitute...
August 21, 2018: Materials
https://www.readbyqxmd.com/read/30126440/a-phase-i-dose-escalation-trial-of-stereotactic-ablative-body-radiotherapy-for-non-spine-bone-and-lymph-node-metastases-destroy-trial
#8
Carole Mercier, Piet Dirix, Paul Meijnders, Peter Vermeulen, Steven Van Laere, Hilde Debois, Philippe Huget, Dirk Verellen
BACKGROUND: In an oligometastatic setting, metastasis-directed treatment could render patients disease free, possibly for a protracted interval. Stereotactic ablative radiotherapy (SABR) is one of the treatment modalities that can be offered to these patients. In addition, the radiobiological qualities of SABR are promising for the use in perceived radioresistant tumours. There is also emerging evidence that SABR can stimulate the immune response, and a specific therapeutic window may exist for the optimal use of radiotherapy as an immune adjuvant...
August 20, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/30123333/the-pattern-of-bone-involvement-management-and-outcomes-in-patients-with-nonsmall-cell-lung-cancer-a-retrospective-study
#9
Abdulrahman M Jazieh, Thuraya S AlSumai, Yosra Z Ali, Nagham R Sheblaq, Mohammad Alkaiyat
CONTEXT AND AIM: The skeleton is a frequent site for metastasis in patients with breast, lung, and prostate cancer. Bone metastasis compromises skeletal integrity leading to skeletal-related events (SREs). This study aims at estimating the prevalence of bone metastasis in lung cancer and describing types of bone involvement, management, outcomes, and overall survival. METHODS: We retrospectively reviewed the charts of 259 patients with nonsmall cell lung cancer who consulted the Department of Medical Oncology at our institution between January 2002 and December 2012...
July 2018: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/30114379/dose-fall-off-during-the-treatment-of-thoracic-spine-metastasis-with-cyberknife-stereotactic-body-radiation-therapy-sbrt
#10
Zhongjian Ju, Jingyuan Wang, Huaiwen Zhang, Lei Du, Wei Xu, Xiaoshen Wang, Ruigang Ge, Jiwei Li, Qingzeng Zheng, Jianxiong Li
CyberKnife stereotactic body radiation therapy (SBRT) is becoming increasingly used for cancer treatment and, to maximize its clinical application, it is important to define the dosimetric characteristics, optimal dose and fractionation regimens. The aim of this study was to evaluate the dose fall-off in two fractionated regimens of CyberKnife SBRT during the treatment of thoracic spinal metastasis. Patients with spinal metastasis involving a vertebra and pedicle were treated with 40 Gy in 5 fractions (n = 4), and patients with spinal metastasis involving only a vertebra received 33 Gy in 3 fractions (n = 4)...
August 2, 2018: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/30092761/an-elderly-patient-presenting-with-a-primary-spinal-multifocal-intradural-extramedullary-pilocytic-astrocytoma-a-case-report-and-review-of-the-literature
#11
Devin McBride, Zaid Aljuboori, Eyas M Hattab, Richard Downs, Shiao Woo, Brian Williams, Joseph Neimat, Eric Burton
BACKGROUND: Pilocytic astrocytoma is a low-grade central nervous system tumor most commonly seen in children. Dissemination from a primary intracranial tumor along the neuroaxis has been described at both presentation and disease progression. However, the development of an intradural extramedullary pilocytic astrocytoma independent of a primary intraparenchymal tumor in an adult patient with no history of pilocytic astrocytoma has rarely been reported. CASE PRESENTATION: A 69-year-old woman presented with progressive myelopathic symptoms and thoracic radicular pain...
August 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/30067919/differential-diagnosis-of-a-pathological-spine-fracture
#12
Priti J Bhatt, Elliot M Greenberg, Brian D Suh
A 71-year-old woman with a 10-month history of atraumatic low back pain was referred to physical therapy after an insidious exacerbation of symptoms. Red flags raised suspicions for spinal compression fracture, necessitating the physical therapist to contact her physician and recommend imaging. Radiographs and magnetic resonance imaging were ordered, the latter of which showed an acute fracture at T10, with lesions at T9 and in the liver suggesting metastasis. Following bone scintigraphy and an ultrasound-guided biopsy of a liver lesion, she was diagnosed with metastatic breast cancer...
July 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/30064201/a-nationwide-study-of-surgery-in-a-newly-diagnosed-spine-metastasis-population
#13
Seil Sohn, Chun Kee Chung, Kyung Do Han, Jin Hyung Jung, Joung Ho Hyeun, Jinhee Kim, Ung-Kyu Chang, Moon Jun Sohn, Sung Hwan Kim
Objective: The aim of this nationwide study was to analyze the current state of patients with newly diagnosed metastatic spine tumors according to surgical methods. Methods: Data was extracted from the Korean Health Insurance Review and Assessment Service database. Surgery was categorized into three methods : fusion, decompression, and vertebroplasty. Data included patient age, sex, health insurance type, and co-morbidities. Survival rates of metastatic spine tumor patients according to each surgical method were evaluated...
August 2, 2018: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/30050751/outcomes-and-prognostic-factors-for-surgically-treated-patients-with-breast-cancer-spine-metastases
#14
Chenglong Zhao, Zhichao Zhang, Nanzhe Zhong, Tianqi Fan, Xin Gao, Zhipeng Wu, Zhenxi Li, Tielong Liu, Jianru Xiao
Purpose: The aim of this study is to provide some useful insights into the treatments, outcomes, and prognostic factors of patients with breast cancer spine metastases (BCSM). Methods: We report a retrospective case series analyzing 87 patients with BCSM who underwent surgical interventions. Independent prognostic factors for SMFS and OS were extracted using univariate and multivariate analyses, the Kaplan-Meier method and the Cox proportional hazards model. Results: The mean time between primary diagnoses and spinal metastases was 46...
September 2018: Journal of Bone Oncology
https://www.readbyqxmd.com/read/30046308/survival-outcomes-and-factors-associated-with-revision-surgery-for-metastatic-disease-of-the-spine
#15
Vignesh K Alamanda, Myra M Robinson, Jeffrey S Kneisl, Leo R Spector, Joshua C Patt
Study Design: Retrospective review of a prospective database. Objective: Certain subset of patients undergoing surgical treatment for spinal metastasis will require a revision surgery in their disease course; however, factors predictive of revision surgery and survival outcomes are largely unknown. The goal of this study is to report on survival outcomes as well as factors predictive of revision surgery in this unique patient population. Methods: A total of 55 patients who met the inclusion criteria were included from January 2010 to December 2015...
2018: Journal of Oncology
https://www.readbyqxmd.com/read/30038545/minimally-invasive-extreme-lateral-approach-in-spinal-lumbar-metastasis
#16
Lucas Castrillon Carmo Machado, Douglas Kenji Narazaki, Willian Gemio Jacobsen Teixeira, Alexandre Fogaça Cristante, Manoel Jacobsen Teixeira, Tarcísio Eloy Pessoa DE Barros
Introduction: The extreme lateral approach has been widely used for the treatment of degenerative diseases. The objective of this study is to present a minimally invasive extreme lateral approach for the treatment of metastatic lesions in the lumbar spine without the use of the evoked potential exam (MEP). Methods: Two patients with spinal metastases and indication for surgery via the anterior approach were treated in a cancer referral center in Brazil. They were placed in right lateral decubitus, and an oblique incision was made, exposing the psoas muscle...
May 2018: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/30029268/the-size-of-simulated-lytic-metastases-affects-the-strain-distribution-on-the-anterior-surface-of-the-vertebra
#17
Marco Palanca, Giovanni Brodano Barbanti, Luca Cristofolini
Metastatic lesions of the vertebra are associated with risk of fracture, which can be disabling and life-threatening. In the literature, attempts are found to identify the parameters that reduce the strength of a metastatic vertebra leading to spine instability. However, a number of controversial issues remain. Our aim was to quantify how the strain distribution in the vertebral body is affected by the presence and by the size of a simulated metastatic defect. Five cadaveric thoracic spine segments were subjected to non-destructive presso-flexion while intact, and after simulation of metastases of increasing size...
June 25, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/30021731/metastasis-of-malignant-myoepithelial-carcinoma-to-the-brain
#18
Nathaniel R Ellens, Sandra Camelo-Piragua, Stephanie M Ellens, Joshua E Simon, Justin C Clark
Myoepithelial tumours are a rare form of salivary gland neoplasm and intracranial metastases have rarely been described. The authors present the case of a 61-year-old patient with a history of primary myoepithelial carcinoma of the right foot. Metastases were found in the third ventricle, left temporal lobe and right frontal lobe. The third ventricular and left temporal lobe tumours were resected in a two-stage operation. Pathology of the third ventricular lesion was most consistent with metastasis. MRI of the spine 2 weeks after his operation revealed an intradural mass with several lesions in the lumbar thecal space suggesting further metastases...
July 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/30012505/retrospective-multicenter-study-by-the-french-spine-society-of-surgical-treatment-for-spinal-metastasis-in-france
#19
Frédéric Sailhan, Solène Prost, Fahed Zairi, Olivier Gille, Hughes Pascal-Mousselard, Saad Bennis, Yann-Philippe Charles, Benjamin Blondel, Stéphane Fuentes
INTRODUCTION: The occurrence of spinal metastasis is a turning point in the progression of cancer. The optimal management has not been well defined. The aim of this study was to identify the various treatments currently being used in France and to determine the benefits of surgical treatment. MATERIAL AND METHODS: The records of patients treated between 2011 and 2015 at seven spine surgery centers in France were reviewed retrospectively. The pain level (VAS), McAfee scale, walking ability and Frankel Grade were evaluated at inclusion and at 6-months postoperative...
September 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/30004865/single-stage-en-bloc-resection-of-a-recurrent-metastatic-osteosarcoma-of-the-pediatric-lumbar-spine-through-multiple-exposures-a-novel-approach
#20
Saurabh Gupta, Zachary S Stinson, Rex A Marco, John P Dormans
To obtain a wide resection and safe margins in recurrent spine osteosarcoma, the surgical approach can include - posterior only, combined posterior and anterior, and combined posterior and anterior with a return to posterior in multiple stages. In our case, we used a novel approach of multiple extensile exposures circumferentially in a single stage with a single surgical prep. We present the case of a 9-year-old female with a history of metastatic osteosarcoma, who previously underwent an attempted en bloc resection with an L3 corpectomy and left below knee amputation...
2018: SICOT-J
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