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Spine metastasis

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https://www.readbyqxmd.com/read/28102349/development-of-patient-specific-phantoms-for-verification-of-stereotactic-body-radiation-therapy-planning-in-patients-with-metallic-screw-fixation
#1
Dongryul Oh, Chae-Seon Hong, Sang Gyu Ju, Minkyu Kim, Bum Yong Koo, SungBack Choi, Hee Chul Park, Doo Ho Choi, Hongryull Pyo
A new technique for manufacturing a patient-specific dosimetric phantom using three-dimensional printing (PSDP_3DP) was developed, and its geometrical and dosimetric accuracy was analyzed. External body contours and structures of the spine and metallic fixation screws (MFS) were delineated from CT images of a patient with MFS who underwent stereotactic body radiation therapy for spine metastasis. Contours were converted into a STereoLithography file format using in-house program. A hollow, four-section PSDP was designed and manufactured using three types of 3DP to allow filling with a muscle-equivalent liquid and insertion of dosimeters...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088217/surgical-treatment-of-upper-cervical-spine-metastases-a-retrospective-study-of-39-cases
#2
Jian Yang, Qi Jia, Dongyu Peng, Wei Wan, Nanzhe Zhong, Yan Lou, Xiaopan Cai, Zhipeng Wu, Chenglong Zhao, Xinghai Yang, Jianru Xiao
BACKGROUND: The surgical treatment of upper cervical spine metastases are controversial up to now. By summarizing and analyzing the clinical data of the upper cervical spine involved metastases treated surgically in our center, we mainly aimed to investigate the surgical decisions and outcomes so as to provide more references for the clinical treatment of this special and complex spine metastasis. METHODS: We evaluated the patients' pre- and post-operative neck pain and neurologic function with paired t test, followed by the statistics of the selection of surgical approaches, ways of reconstruction, and related complications...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28087968/thymic-carcinoma-presenting-with-an-unusual-and-delayed-metastasis-to-the-neural-foramen-mimicking-thoracic-spinal-radiculopathy
#3
H M Low, C F Wong, M W H'ng
We report a case of metastatic thymic carcinoma which presented as an enhancing mass located in the neural foramen of the thoracic spine. More common tumours which arise in the neural foramen would include a neurogenic tumour or developmental anomalies such as a foregut duplication cyst. This case is singular firstly because the lesion present as radiculopathy which mimics a neurogenic tumour. Secondly, the presentation was unusually delayed as the patient presented to our centre more than a decade after the resection of the primary tumour in another institution...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28081926/asymmetrical-vertebral-collapse-from-spinal-metastasis-in-lower-thoracic-and-lumbar-spine
#4
Takayoshi Suzuki, Hirohisa Katagiri, Tatsuya Noda, Shusuke Ota, Hideki Murata, Junji Wasa, Seiichi Hosaka, Tetsuo Shimoyama, Mitsuru Takahashi
OBJECTIVE: The purpose of this study was to investigate the differences between spinal metastasis and osteoporotic compression fractures on plain X-ray images, focusing on asymmetrical vertebral collapse and fracture level. MATERIALS AND METHODS: This study included 180 patients with pathological collapse from spinal metastasis (188 vertebrae) who were treated at our institution and 70 patients (92 vertebrae) with osteoporotic compression fractures. Anteroposterior X-ray images of the lower thoracic and lumbar spine were evaluated for asymmetrical collapse deformity...
January 9, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28057095/-comparison-of-curative-effect-and-prognosis-analysis-of-patients-with-spinal-metastases-treated-by-percutaneous-vertebroplasty-combined-with-postoperative-radiotherapy-and-radiotherapy-alone
#5
X Y Cao, Y S Liu, M X Lei, S B Liu, S G Zhou, Y C Cao, W G Jiang
Objective: To evaluate the efficacy of percutaneous vertebroplasty(PVP) combined with postoperative radiotherapy and radiotherapy alone in the treatment of spinal metastatic tumors and to evaluate the prognostic factors for survival. Methods: From December 2011 to December 2015, according to the choice of treatment, patients in group A(60 cases) were treated with PVP combined with postoperative radiotherapy and those in group B(50 cases) underwent radiotherapy alone, age, sex, primary tumor type , and other basic characteristics were analyzed in both groups in department of orthopedics and radiotherapy department, 307 Hospital of the People's Liberation Army...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28055969/tmprss2-erg-fusion-promotes-prostate-cancer-metastases-in-bone
#6
Rachel Deplus, Carine Delliaux, Nathalie Marchand, Anne Flourens, Nathalie Vanpouille, Xavier Leroy, Yvan de Launoit, Martine Duterque-Coquillaud
Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear. Since bone metastasis starts with the tropism of cancer cells to bone through specific migratory and invasive processes involving osteomimetic capabilities, it is crucial to better our understanding of the influence of TMPRSS2-ERG expression in the mechanisms underlying the bone tropism properties of PCa cells...
December 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/28055232/biological-features-of-a-renal-cell-carcinoma-cell-line-derived-from-spinal-metastasis
#7
Zhenhua Zhou, Yan Li, Huiqing Wang, Xudong Wang, Jianru Xiao
The establishment of a metastatic renal cell carcinoma (mRCC) cell line can facilitate the search for molecular mechanisms involved in RCC metastasis. A novel human mRCC cell line, designated RCC96, was established from an mRCC of the spine from a 65-year-old Chinese man. Morphology, cell cycle phase, chromosome number, cell capability of migration, tumorigenicity in nude mice, and cytogenetic features of RCC96 were investigated. Cell growth curve was detected and the cell number doubling time was 52 h. Karyotype analysis showed that these cells were polyploidy...
January 5, 2017: DNA and Cell Biology
https://www.readbyqxmd.com/read/28047211/su-f-t-512-a-dosimetric-comparison-for-palliative-spine-metastasis-treatments-3-d-vs-conformal-arc
#8
V Ulizio, M Taylor
PURPOSE: Spine metastases have traditionally been treated using a parallel opposed 3-D technique: an anterior field and a posterior field (AP/PA). This has proven to give the lesions adequate coverage. The downside to this type of treatment is that the full prescription dose covers a large area of the patient and can go through critical organs such as the heart, spine, lungs, bowel, and others depending on the vertebrae being treated. Conformal arc therapy can also be used for this type of treatment...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044212/skeletal-related-events-and-prognosis-in-urothelial-cancer-patients-with-bone-metastasis
#9
Yusuke Tsuda, Tohru Nakagawa, Yusuke Shinoda, Atsushi Kanatani, Taketo Kawai, Satoru Taguchi, Yukio Yamada, Ryoko Sawada, Haruki Kume, Yukio Homma, Sakae Tanaka, Hirotaka Kawano
BACKGROUND: The aim of the present study was to elucidate the details of bone metastasis (BM) and the resulting skeletal-related events (SREs), and survival and prognostic factors, in urothelial cancer (UC) patients with BM. METHODS: A total of 48 UC patients with BM who were treated at our institution between 1994 and 2013 were enrolled. Details of BM and SREs were investigated. The Kaplan-Meier method was used to estimate survival duration. Relationships between several clinical features and survival were analyzed using the log-rank test and the Cox hazard model...
January 2, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28041319/rapid-and-complete-radiological-resolution-of-an-intradural-cervical-cord-lung-cancer-metastasis-treated-with-spinal-stereotactic-radiosurgery-case-report
#10
E Emily Bennett, Camille Berriochoa, Ghaith Habboub, Scott Brigeman, Samuel T Chao, Lilyana Angelov
Stereotactic radiosurgery (SRS) has emerged as a treatment option for patients with spinal metastatic disease. Although SRS has been shown to be successful in a multitude of extradural metastatic tumors causing cord compression, very few cases of intradural treatment have been reported. The authors present a rare case of an intradural extramedullary metastatic small cell lung cancer lesion to the cervical spine resulting in cord compression in an area that had also been extensively pretreated with conventional external-beam radiation therapy...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28041318/dynamic-contrast-enhanced-magnetic-resonance-imaging-of-osseous-spine-metastasis-before-and-1-hour-after-high-dose-image-guided-radiation-therapy
#11
Eric Lis, Atin Saha, Kyung K Peck, Joan Zatcky, Michael J Zelefsky, Yoshiya Yamada, Andrei I Holodny, Mark H Bilsky, Sasan Karimi
OBJECTIVE High-dose image-guided radiation therapy (HD IGRT) has been instrumental in mitigating some limitations of conventional RT. The recent emergence of dynamic contrast-enhanced (DCE) MRI to investigate tumor physiology can be used to verify the response of human tumors to HD IGRT. The purpose of this study was to evaluate the near-immediate effects of HD IGRT on spine metastases through the use of DCE MRI perfusion studies. METHODS Six patients with spine metastases from prostate, thyroid, and renal cell carcinoma who underwent HD IGRT were studied using DCE MRI prior to and 1 hour after HD IGRT...
January 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28034746/new-imaging-characteristics-for-predicting-postoperative-neurological-status-in-patients-with-metastatic-epidural-spinal-cord-compression-a-retrospective-analysis-of-81-cases
#12
Mingxing Lei, Shubin Liu, Shaoxing Yang, Yaosheng Liu, Cheng Wang, Hongjun Gao
BACKGROUND CONTEXT: Several clinical features have been proposed for prediction of postoperative functional outcome in patients with metastatic epidural spinal cord compression (MESCC). However, few articles address the relationship between preoperative imaging characteristics and the postoperative neurological status. PURPOSE: This study aims to analyze the postoperative functional outcome and identify new imaging parameters for predicting postoperative neurological status in patients with MESCC...
December 26, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28031519/remarkable-bone-formation-following-gefitinib-for-extensive-lytic-bone-metastasis-a-report-of-two-cases
#13
Elrofai Suliman Bashir, Angel Khor Nee Kwan, Chris Yin Wei Chan, Kwan Mun Keong
Gefitinib inhibits the epidermal growth factor receptor tyrosine kinase and improves survival in patients with non-small-cell lung cancer. We report 2 patients with extensive lytic bony metastasis in the spine and pelvis secondary to advanced pulmonary adenocarcinoma who were treated with gefitinib and had remarkable bone formation in the lytic bone lesions in the spine and pelvis. Surgery for stabilisation was avoided.
December 2016: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28018768/rare-intradural-cervical-nerve-root-metastasis-of-follicular-thyroid-carcinoma
#14
Joseph Keen, Elena Milosavljevic, George Hanna, Vadim Gospodarev, Ravi Raghavan, Samer Ghostine
Intradural extramedullary nerve root metastasis is extremely unusual with only a handful of cases reported, and it presents most commonly in the thoracic and lumbosacral regions. We report the first case of metastasis to a ventral cervical nerve root in a patient with low-grade follicular thyroid carcinoma thought to be in remission for several years. Histopathology demonstrated malignant transformation and invasion of the nerve root. This case underscores that any history of malignancy regardless of staging, grading, or remission status should raise the suspicion of metastasis as it can mimic other spine and nerve sheath tumors and represent malignant transformation...
November 24, 2016: Curēus
https://www.readbyqxmd.com/read/27988342/prognostic-factors-in-patients-with-spinal-metastasis-a-systematic-review-and-meta-analysis
#15
Panya Luksanapruksa, Jacob M Buchowski, William Hotchkiss, Sasima Tongsai, Sirichai Wilartratsami, Areesak Chotivichit
BACKGROUND CONTEXT: Incidence of symptomatic spinal metastasis has increased due to improvement in treatment of the disease. One of the key factors that influences decision-making is expected patient survival. To our knowledge, no systematic reviews or meta-analysis have been conducted which review independent prognostic factors in spinal metastases PURPOSE: To determine independent prognostic factors that affect outcome in patients with metastatic spine disease. STUDY DESIGN: Systematic literature review and meta-analysis of publications for prognostic factors in spinal metastatic disease...
December 14, 2016: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/27987335/gestational-choriocarcinoma-rare-spinal-metastasis-during-a-viable-pregnancy
#16
Tatsuya Ishiguro, Takehiro Serikawa, Tetsuro Yahata, Takayuki Enomoto
Gestational choriocarcinoma metastasizing to the bones, especially to the spine, is extremely rare. In addition, there are few reports of choriocarcinoma during a viable pregnancy. We report a case of gestational choriocarcinoma that metastasized to the lumbar spine during a viable pregnancy in a 41-year-old woman with a history of a missed abortion. A heterogeneous cervical mass was detected at gestational week 16. Subsequently, a metastatic lesion appeared during the pregnancy, and fetal demise in utero occurred...
December 17, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27984252/perioperative-complications-of-spinal-metastases-surgery
#17
Panya Luksanapruksa, Jacob M Buchowski, Lukas P Zebala, Christopher K Kepler, Weerasak Singhatanadgige, David B Bumpass
The incidence of symptomatic spinal metastasis has increased due to treatment improvements and longer patient survival. More patients with spinal tumors are choosing operative treatment with an associated increased rate of perioperative complications. Operative metastatic disease treatment complication rates have also increased with overall rates ranging from 5.3% to 76.20%. The common surgical-related complications are iatrogenic dural injury and wound complications. The most common postoperative medical complications are delirium, pneumonia, and deep vein thrombosis...
December 15, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27939398/intradural-extramedullary-ewing-s-sarcoma-a-case-report-and-review-of-the-literature
#18
Konstantinos Paterakis, Alexandros Brotis, Anastasia Tasiou, Vasiliki Kotoula, Eftychia Kapsalaki, Marianna Vlychou
INTRODUCTION: Extra-skeletal Ewing's sarcomas are very rare lesions to the spine surgeon, with the intradural, extramedullary lesions being even rarer. Herein we present a patient with an intradural, extramedullary form of Ewing's sarcoma and review the relevant literature. The medical records, operative reports, radiographical studies and histological examinations of a single patient are retrospectively reviewed. CASE REPORT: A 31-year old male presented with back-pain, right-leg progressive paraparesis, and inability to walk...
November 30, 2016: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/27905158/metastatic-spinal-cord-compression-from-basal-cell-carcinoma-of-the-skin-treated-with-surgical-decompression-and-vismodegib-case-report-and-review-of-hedgehog-signalling-pathway-inhibition-in-advanced-basal-cell-carcinoma
#19
J McGrane, S Carswell, T Talbot
We report a case of a 66-year-old man with locally advanced and metastatic basal cell carcinoma (BCC) causing spinal cord compression, which was treated with spinal surgery and subsequent vismodegib. The patient presented with a large fungating chest wall lesion and a metastasis in T8 that was causing cord compression. He had neurosurgical decompression of the T8 lesion and fixation of the spine. Punch biopsy from the fungating chest wall lesion showed a BCC with some malignant squamous differentiation (basosquamous)...
January 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/27900552/giant-chordoma-in-the-thoracolumbar-spine-a-case-report-and-literature-review
#20
Feifei Pu, Baichuan Wang, Jianxiang Liu, Fengxia Chen, Zengwu Shao
STUDY DESIGN: Case report. PURPOSE: We present a rare case of a giant chordoma in the thoracolumbar spine and review the current literature. We describe its complicated clinical progression, hoping to shed light on the clinical management of this complex tumor. METHODS: We present a previously healthy 41-year-old man who experienced progressive low back pain at T10-L2 for the past 2 years. A giant tumor was detected on magnetic resonance imaging, and aspiration biopsy was used to obtain a definite pathological diagnosis...
November 29, 2016: European Spine Journal
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