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https://www.readbyqxmd.com/read/28801985/between-day-reliability-of-local-thermal-hyperaemia-in-the-forearm-and-index-finger-using-single-point-laser-doppler-flowmetry
#1
Gregory W McGarr, Gary J Hodges, Stephen S Cheung
OBJECTIVE: To assess between-day reliability for local thermal hyperaemia (LTH) in glabrous and non-glabrous index finger skin and non-glabrous forearm skin, with single point laser-Doppler flowmetry. METHODS: Part-1: In healthy, habitually active males (n=10), LTH was examined twice (~7-10 d apart) for both skin types on the index finger. Part-2: Identical testing was performed on the volar forearm. Local heating (33-42°C at 1°C·20 s(-1) +20 min at 44°C) was performed at all skin sites and baseline, initial peak, and plateau phases were identified...
August 12, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
https://www.readbyqxmd.com/read/28796444/the-michigan-risk-score-to-predict-peripherally-inserted-central-catheter-associated-thrombosis
#2
Vineet Chopra, Scott Kaatz, Anna Conlon, David Paje, Paul J Grant, Mary A M Rogers, Steven J Bernstein, Sanjay Saint, Scott A Flanders
BACKGROUND: Peripherally inserted central catheters (PICCs) are associated with upper extremity deep vein thrombosis (DVT). We developed a score to predict risk of PICC-related thrombosis. METHODS: Using data from the Michigan Hospital Medicine Safety consortium, image-confirmed upper-extremity DVT cases were identified. A logistic, mixed effects model with hospital-specific random intercepts was used to identify factors associated with PICC-DVT. Points were assigned to each predictor, stratifying patients into four classes of risk...
August 10, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28793993/taurolidine-citrate-heparin-lock-reduces-catheter-related-bloodstream-infections-in-intestinal-failure-patients-dependent-on-home-parenteral-support-a-randomized-placebo-controlled-trial
#3
Siri Tribler, Christopher F Brandt, Anne H Petersen, Jørgen H Petersen, Kristian A Fuglsang, Michael Staun, Per Broebech, Claus E Moser, Palle B Jeppesen
Background: In patients with intestinal failure who are receiving home parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) inflict health impairment and high costs.Objective: This study investigates the efficacy and safety of the antimicrobial catheter lock solution, taurolidine-citrate-heparin, compared with heparin 100 IE/mL on CRBSI occurrence.Design: Forty-one high-risk patients receiving HPS followed in a tertiary HPS unit were randomly assigned in a double-blinded, placebo-controlled trial...
August 9, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28793847/effects-of-electrode-deactivation-on-speech-recognition-in-multichannel-cochlear-implant-recipients
#4
Kara C Schvartz-Leyzac, Teresa A Zwolan, Bryan E Pfingst
OBJECTIVES: The objective of the current study is to evaluate how speech recognition performance is affected by the number of active electrodes that are turned off in multichannel cochlear implants. Several recent studies have demonstrated positive effects of deactivating stimulation sites based on an objective measure in cochlear implant processing strategies. Previous studies using an analysis of variance have shown that, on average, cochlear implant listeners' performance does not improve beyond eight active electrodes...
August 10, 2017: Cochlear Implants International
https://www.readbyqxmd.com/read/28777416/ultrasound-guided-intravenous-catheter-insertion-in-a-prone-patient-using-a-t-probe-in-emergency-setting
#5
Antonio Lazzari, Roberto Bini, Roberto Bertucci, Antonio Coletti, Paolo Voghera
INTRODUCTION: Central venous catheterizations are common intraoperative procedures.Central venous catheter (CVC) placements are usually performed with patients lying in the supine position using real-time ultrasound (US) guidance. CASE DESCRIPTION: A 43-year-old man underwent open right popliteal artery reconstruction in the prone position for a limb-threatening injury. Excessive continuous intraoperative bleeding, increased by a coexisting pelvic fracture, was temporarily stabilized by a T POD device, but with the need of external fixation, required the placement of CVC, which was not feasible whilst in the prone position without US help...
July 26, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28777409/potential-role-of-a-subcutaneously-anchored-securement-device-in-preventing-dislodgment-of-tunneled-cuffed-central-venous-devices-in-pediatric-patients
#6
Andrea Dolcino, Antonio Salsano, Andrea Dato, Nicola Disma, Alessio Pini Prato, Filippo Bernasconi, Luigi Montagnini, Stefano Avanzini, Michela Bevilacqua, Giovanni Montobbio, Girolamo Mattioli, Clelia Zanaboni
INTRODUCTION: The potential drawbacks of tunneled-cuffed catheters are complications such as local or systemic infection, dislodgment, rupture, malfunction, and deep venous thrombosis. Aim of this study is to describe the incidence of complications, focusing on dislodgment and on the role of new securement devices in reducing this annoying issue. METHODS: We enrolled all pediatric patients with tunneled-cuffed central venous catheters (CVCs) inserted at the Giannina Gaslini Institute during a 16-month period...
August 27, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28777405/bursting-pressure-of-triple-lumen-central-venous-catheters-under-static-and-dynamic-loads
#7
Tim Beckingham, Andy Roberts, Alana St John, Gerry O'Callaghan
INTRODUCTION: Central venous catheter (CVC) access is commonplace in intensive care units. Patients undergoing computed tomographic angiography require injection of contrast at high flow rates (4.5 mL/s), often CVC access is not used due to safety concerns. The CVC might rupture at high flow rates, resulting in CVC fragmentation and embolization or contrast extravasation.The objective of this study is to determine the pressure required to burst a CVC under static load and compare this to the pressure generated by injection of contrast at high flow rates (dynamic load) through the distal (16-g) lumen of a triple-lumen CVC...
August 3, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28766820/influence-of-the-respiratory-cycle-on-caudal-vena-cava-diameter-measured-by-sonography-in-healthy-foals-a-pilot-study
#8
M C Tuplin, A E Romero, S R Boysen
BACKGROUND: Intravascular volume assessment in foals is challenging. In humans, intravascular volume status is estimated by the caudal vena cava (CVC) collapsibility index (CVC-CI) defined as (CVC diameter at maximum expiration [CVCmax ] - CVC diameter at minimal inspiration [CVCmin ])/CVCmax × 100%. HYPOTHESIS/OBJECTIVES: To determine whether the CVC could be sonographically measured in healthy foals, determine differences in CVCmax and CVCmin , and calculate inter- and intrarater variability between 2 examiners...
August 1, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28762929/-risk-factors-of-cardiovascular-complications-after-beating-heart-coronary-artery-bypass-grafting-in-patients-with-type-two-diabetes
#9
S Y Borodashkina, K V Protasov, V A Podkamennyi
AIM: to determine risk factors of early cardiovascular complications after beating-heart coronary artery bypass grafting (CABG) in patients with ischemic coronary disease (IHD) and type two diabetes (D2). MATERIALS AND METHODS: We included into this study 188 patients (mean age 59 years, 85.1% men) with IHD and D2 who underwent off-pump CABG. The following cardiovascular complications (CVC) registered within 7 days after surgery were analyzed: myocardial infarction (MI), stroke/transient ischemic attack (S/TIA), atrial fibrillation (AF)...
March 2017: Kardiologiia
https://www.readbyqxmd.com/read/28761091/a-novel-pharmacodynamic-assay-to-evaluate-the-effects-of-crystallization-inhibitors-on-calcium-phosphate-crystallization-in-human-plasma
#10
M D Ferrer, M M Pérez, M M Cànaves, J M Buades, C Salcedo, J Perelló
Cardiovascular calcification (CVC) is a progressive complication of chronic kidney disease and a predictor of CV events and mortality. The use of biomarkers to predict CV risk and activities of potential or current treatment drugs in these patients could have a crucial impact on therapeutic approaches. Our aim was to develop a novel assay for measurement of the rate of calcium phosphate crystallization in human plasma and provide a tool to evaluate the effects of crystallization inhibitors. The efficacy of inhibitors was determined by adding inhibitory compounds (polyphosphates, fetuin-A, sodium thiosulfate or citrate) to control samples...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28751373/heat-shock-protein-90-contributes-to-cutaneous-vasodilation-through-activating-nitric-oxide-synthase-in-young-male-adults-exercising-in-the-heat
#11
Naoto Fujii, Sarah Yan Zhang, Brendan D McNeely, Takeshi Nishiyasu, Glen P Kenny
While the mechanisms underlying the control of cutaneous vasodilation has been extensively studied, there remains a lack of understanding of the different factors that may modulate cutaneous perfusion during an exercise-induced heat stress. We evaluated the hypothesis that heat shock protein 90 (HSP90) contributes to the heat loss response of cutaneous vasodilation via the activation of nitric oxide synthase (NOS) during exercise in the heat. In eleven young males (25±5 years), cutaneous vascular conductance (CVC) was measured at four forearm skin sites that were continuously treated with 1) Lactated Ringers solution (Control), 2) NOS inhibition with 10 mM L-NAME, 3) HSP90 inhibition with 178 μM Geldanamycin, or 4) a combination of 10 mM L-NAME and 178 μM Geldanamycin...
July 27, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28748891/study-of-chronic-kidney-disease-mineral-bone-disorders-in-newly-detected-advanced-renal-failure-patients-a-hospital-based-cross-sectional-study
#12
Praveen Kumar Etta, R K Sharma, Amit Gupta
We aim to evaluate the disturbances in mineral metabolism, abnormalities in bone mineral density (BMD), and extraskeletal calcification in newly detected, untreated predialysis stage 4 and 5 chronic kidney disease (CKD) patients at a tertiary care hospital in North India. This is cross-sectional observational study. A total of 95 (68 males, 27 females) newly detected patients underwent clinical evaluation, biochemical assessment [serum calcium, phosphorus, alkaline phosphatase (ALP), albumin, creatinine, intact parathyroid hormone (iPTH), 25- hydroxyvitamin D (25(OH)D)], BMD measurement (at spine, hip, and forearm) by dual-energy X-ray absorptiometry (DXA), lateral abdominal radiograph [for abdominal aortic calcification (AAC)], skeletal survey (to look for any abnormality including fractures), and echocardiography [for any cardiac valvular calcification (CVC)]...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28744885/water-infused-surface-protection-as-an-active-mechanism-for-fibrin-sheath-prevention-in-central-venous-catheters
#13
David W Sutherland, Xin Zhang, Joseph L Charest
Protein adhesion in central venous catheters (CVCs) leads to fibrin sheath formation, the precursor to thrombotic and biofilm-related CVC failures. Advances in material properties and surface coatings do not completely prevent fibrin sheath formation and post-formation treatment options are limited and expensive. We propose water infused surface protection (WISP), an active method for prevention of fibrin sheath formation on CVCs, which creates a blood-free boundary layer on the inner surface of the CVC, limiting blood contact with the CVC lumen wall...
July 26, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28743533/should-non-bacteraemic-patients-with-a-colonized-catheter-receive-antimicrobial-therapy
#14
V De Egea, M Guembe, A Rodríguez-Borlado, M J Pérez-Granda, C Sánchez-Carrillo, E Bouza
OBJECTIVES: The impact of antimicrobial therapy on the outcomes of patients with colonized catheters and no bacteraemia has not been assessed. This study assessed whether targeted antibiotic therapy is related to a poor outcome in patients with positive cultures of blood drawn through a non-tunnelled central venous catheter (CVC) and without concomitant bacteraemia. METHODS: This was a retrospective study involving adult patients with positive blood cultures drawn through a CVC and negative peripheral vein blood cultures...
July 22, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28738768/current-status-of-the-pharmacokinetics-and-pharmacodynamics-of-hiv-1-entry-inhibitors-and-hiv-therapy
#15
Fengyan Xu, Edward P Acosta, Liyu Liang, Yingchun He, Juan Yang, Corenna Kerstner-Wood, Qingshang Zheng, Jihan Huang, Kun Wang
Human immunodeficiency virus (HIV) entry inhibitors target the first step of the HIV life cycle and efficiently inhibit HIV from infecting the immune cells which is a key prerequisite for viral spread. Because of their unique mechanism of action on cell-cell transmission they may provide a promising perspective for the treatment of AIDS. Maraviroc (MVC) and Enfuvirtide (ENF) have been approved by the FDA for the treatment of HIV-1 infection. Attachment inhibitors (BMS-663068 and TNX-355) and co-receptor inhibitors (PRO-140 and Cenicriviroc (CVC)) have reached phase II or III clinical trials...
July 24, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28731490/lancisi-s-sign-and-central-venous-catheter-tip-position-a-case-report
#16
Valentina Vigo, Piero Lisi, Giuseppe Galgano, Carlo Lomonte
INTRODUCTION: Valvular disease and pulmonary hypertension are common conditions in haemodialysis patients. In presence of tricuspid regurgitation, an increased retrograde blood flow into the right atrium during ventricle systole results in a typical modification of the normal venous waveform, creating a giant c-v wave. This condition clinically appears as a venous palpable pulsation within the internal jugular vein, also known as Lancisi's sign. CASE REPORT: An 83-year-old woman underwent haemodialysis for 9 years...
July 19, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28721223/atrial-fibrillation-in-a-preterm-newborn-with-structurally-normal-heart
#17
Pier Paolo Bassareo, Andrea Raffaele Marras, Mariangela Marras, Silvia Marras, Giuseppe Mercuro
Atrial fibrillation (AF) is a really uncommon arrhythmia in newborns. Here, we report the case of a 1-day-old infant who was recovered in Neonatal Intensive Care Unit for a twin-to-twin transfusion. The appearance of an unexpected AF was registered at his continuous electrocardiographic monitoring. Both chest X-ray and echocardiographic examination revealed the anomalous insertion of the tip of a central venous catheter (CVC) into the heart ('umbilical artery → inferior vena cava → right atrium → patent foramen ovale → left atrium')...
March 2017: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28710090/the-clinical-and-economic-effect-of-vascular-access-selection-in-patients-initiating-hemodialysis-with-a-catheter
#18
Alian Al-Balas, Timmy Lee, Carlton J Young, Jeffrey A Kepes, Jill Barker-Finkel, Michael Allon
Patients in the United States frequently initiate hemodialysis with a central venous catheter (CVC) and subsequently undergo placement of a new arteriovenous fistula (AVF) or arteriovenous graft (AVG). Little is known about the clinical and economic effects of initial vascular access choice. We identified 479 patients starting hemodialysis with a CVC at a large medical center (during 2004-2012) who subsequently had an AVF (n=295) or AVG (n=105) placed or no arteriovenous access (CVC group, n=71). Compared with patients receiving an AVG, those receiving an AVF had more frequent surgical access procedures per year (1...
July 14, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28700180/-superior-cava-vein-stenosis-in-a-hemodialysis-patient-with-long-term-central-venous-catheter-and-vascular-graft-a-case-report
#19
Carlo Jovane, Piera Farfaglia, Anna Maria Ierardi, Laura Rimoldi, Elisabetta Sogni, Carmela Figliola, Daniela Pogliani, Matteo Tozzi, Elena Caramella, Pasquale Esposito, Alessandro Castiglioni
Recently, the use of central venous catheters (CVC) as a vascular access in patients undergoing hemodialysis is significantly increased, mainly because of the aging of this population and the presence of several comorbidities. However, the implantation and the long stay of CVC are associated with many complications. Among them, central venous stenosis represents one of the most common problems that, if not properly diagnosed, could lead to vascular thrombosis and consequent vascular access malfunction. Here, we report a case of a 38-year-old patient, who underwent hemodialysis firstly by a CVC long-term into right jugular vein and then by a prosthetic fistula in the ipsilateral limb...
June 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28695442/fistula-first-initiative-historical-impact-on-vascular-access-practice-patterns-and-influence-on-future-vascular-access-care
#20
Timmy Lee
The vascular access is the lifeline for the hemodialysis patient. In the United States, the Fistula First Breakthrough Initiative (FFBI) has been influential in improving use of arteriovenous fistulas (AVF) in prevalent hemodialysis patients. Currently, prevalent AVF rates are near the goal of 66% set forth by the original FFBI. However, central venous catheter (CVC) rates remain very high in the United States in patients initiating hemodialysis, nearly exceeding 80%. A new direction of the of the FFBI has focused on strategies to reduce CVC use, and subsequently the FFBI has now been renamed the "Fistula First-Catheter Last Initiative"...
July 10, 2017: Cardiovascular Engineering and Technology
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