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https://www.readbyqxmd.com/read/29773496/reflections-on-methodical-approaches-to-hematopoietic-stem-cell-collection-in-children
#1
REVIEW
Claudia Del Fante, Jerard Seghatchian, Cesare Perotti
Pediatric peripheral blood stem cell collection (PBSC) is challenging because it has potentially more side effects than in adults due to the small body mass and unique physiology of children. The extracorporeal volume of the cell separator device, poor venous access and metabolic complications due to citrate toxicity are the main problems to face during PBSC collection. These aspects are more relevant in very low body weight (BW) children of 20 kg or lower. An efficient, experienced and well-prepared team of pediatricians, apheresis physicians and nurses, and physicians involved in CVC positioning is crucial to performing a safe PBSC collection...
May 9, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29766395/nonword-repetition-stimuli-for-vietnamese-speaking-children
#2
Giang Pham, Kerry Danahy Ebert, Kristine Thuy Dinh, Quynh Dam
Nonword repetition (NWR) has been a widely used measure of language-learning ability in children with and without language disorders. Although NWR tasks have been created for a variety of languages, minimal attention has been given to Asian tonal languages. This study introduces a new set of NWR stimuli for Vietnamese. The stimuli include 20 items ranging in length from one to four syllables. The items consist of dialect-neutral phonemes in consonant-vowel (CV) and CVC sequences that follow the phonotactic constraints of the language...
May 15, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29766294/influence-of-dietary-nitrate-supplementation-on-local-sweating-and-cutaneous-vascular-responses-during-exercise-in-a-hot-environment
#3
Tatsuro Amano, Dai Okushima, Brynmor C Breese, Stephen J Bailey, Shunsaku Koga, Narihiko Kondo
PURPOSE: We investigated the influence of inorganic nitrate ([Formula: see text]) supplementation on local sweating and cutaneous vascular responses during exercise in hot conditions. METHOD: Eight healthy, young subjects were assigned in a randomized, double-blind, crossover design to receive [Formula: see text]-rich beetroot (BR) juice (140 mL/day, containing ~ 8 mmol of [Formula: see text]) and [Formula: see text]-depleted placebo (PL) juice (140 mL/day, containing ~ 0...
May 15, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29761169/prolonged-cenicriviroc-therapy-reduces-hepatic-fibrosis-despite-steatohepatitis-in-a-diet-induced-mouse-model-of-nonalcoholic-steatohepatitis
#4
Annie J Kruger, Bryan C Fuchs, Ricard Masia, Jacinta A Holmes, Shadi Salloum, Mozhdeh Sojoodi, Diego S Ferreira, Stephanie M Rutledge, Peter Caravan, Nadia Alatrakchi, Pam Vig, Eric Lefebvre, Raymond T Chung
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease projected to become the leading cause of cirrhosis and liver transplantation in the next decade. Cenicriviroc (CVC), a dual chemokine receptor 2 and 5 antagonist, prevents macrophage trafficking and is under clinical investigation for the treatment of human NASH fibrosis. We assessed the efficacy and durability of short and prolonged CVC therapy in a diet-induced mouse model of NASH, the choline deficient, L-amino acid-defined, high-fat diet (CDAHFD) model...
May 2018: Hepatology Communications
https://www.readbyqxmd.com/read/29755293/role-of-sequence-variations-in-ahr-gene-towards-modulating-smoking-induced-lung-cancer-susceptibility-in-north-indian-population-a-multiple-interaction-analysis
#5
Sneha Budhwar, Charu Bahl, Siddharth Sharma, Navneet Singh, Digambar Behera
Background: AhR, a ubiquitously expressed ligand-activated transcription factor, upon its encounter with the foreign ligands activates the transcriptional machinery of genes encoding for bio-transformation enzymes like CYP1A1 hence, mediating the metabolism of Poly aromatic hydrocarbons and nitrosamines which account for the maximally found carcinogen in cigarette smoke. Polymorphic variants of AhR play a significant role and are held responsible for disposing the individuals with greater chances of acquiring lung cancer...
May 2018: Current Genomics
https://www.readbyqxmd.com/read/29751343/clavanin-a-bioconjugated-fe-3-o-4-silane-core-shell-nanoparticles-for-thermal-ablation-of-bacterial-biofilms
#6
Kalline L Ribeiro, Isaac A M Frías, Octavio L Franco, Simoni C Dias, Ailton A Sousa-Junior, Osmar N Silva, Andris F Bakuzis, Maria D L Oliveira, Cesar A S Andrade
The use of central venous catheters (CVC) is highly associated with nosocomial blood infections and its use largely requires a systematic assessment of benefits and risks. Bacterial contamination of these tubes is frequent and may result in development of microbial consortia also known as biofilm. The woven nature of biofilm provides a practical defense against antimicrobial agents, facilitating bacterial dissemination through the patient's body and development of antimicrobial resistance. In this work, the authors describe the modification of CVC tubing by immobilizing Fe3 O4 -aminosilane core-shell nanoparticles functionalized with antimicrobial peptide clavanin A (clavA) as an antimicrobial prophylactic towards Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29749656/establishment-of-reference-values-of-the-caudal-vena-cava-by-fast-ultrasonography-through-different-views-in-healthy-dogs
#7
Elodie Darnis, Soren Boysen, Anne-Christine Merveille, Loïc Desquilbet, Serge Chalhoub, Kris Gommeren
BACKGROUND: Clinical assessment of intravascular volume status is challenging. In humans, ultrasonographic assessment of the inferior vena cava diameter, directly or as a ratio to the aortic diameter is used to estimate intravascular volume status. OBJECTIVES: To ultrasonographically obtain reference values (RV) for caudal vena cava diameter (CVCD ), area (CVCa ) and aortic ratios using 3 views in awake healthy dogs. ANIMALS: One hundred and twenty-six healthy adult dogs from clients, students, faculty, or staff...
May 10, 2018: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29744246/comparative-study-of-three-methods-for-depth-of-central-venous-catheter-placement-in-children-an-observational-pilot-study
#8
Vaishali Chaskar, Priyanka Pradeep Karnik, Nandini Malay Dave, Madhu Garasia
Objective: Central venous cannulation of the internal jugular vein is difficult in paediatric patients because of the small size of the vein and anatomic variations. Many studies have shown the accuracy of various formulae for calculating the depth of placement. The aim of this study was to assess the most reliable method for central venous catheter (CVC) tip placement in paediatric patients. Methods: Sixty-nine patients in the age groups from 0 to 12 years were divided in three groups for three published techniques for catheter tip placement...
April 2018: Turkish Journal of Anaesthesiology and Reanimation
https://www.readbyqxmd.com/read/29742152/characterization-of-snf472-pharmacokinetics-and-efficacy-in-uremic-and-non-uremic-rats-models-of-cardiovascular-calcification
#9
Miguel D Ferrer, Markus Ketteler, Fernando Tur, Eva Tur, Bernat Isern, Carolina Salcedo, Pieter H Joubert, Geert J Behets, Ellen Neven, Patrick C D'Haese, Joan Perelló
End-stage renal disease is strongly associated with progressive cardiovascular calcification (CVC) and there is currently no therapy targeted to treat CVC. SNF472 is an experimental formulation under development for treatment of soft tissue calcification. We have investigated the pharmacokinetics of SNF472 administration in rats and its inhibitory effects on CVC. SNF472 was studied in three rat models: (1) prevention of vitamin D3-induced CVC with an intravenous SNF472 bolus of 1 mg/kg SNF472, (2) inhibition of progression of vitamin D3-induced CVC with a subcutaneous SNF472 bolus of 10 or 60 mg/kg SNF472, starting after calcification induction, (3) CVC in adenine-induced uremic rats treated with 50 mg/kg SNF472 via i...
2018: PloS One
https://www.readbyqxmd.com/read/29741459/the-importance-of-correctly-characterising-the-english-spelling-system-when-devising-and-evaluating-methods-of-reading-instruction-comment-on-taylor-davis-and-rastle-2017
#10
Jeffrey S Bowers, Peter N Bowers
Taylor, Davis, and Rastle employed an artificial language learning paradigm to compare phonics and meaning-based approaches to reading instruction. Adults were taught consonant, vowel, and consonant (CVC) words composed of novel letters when the mappings between letters and sounds were completely systematic and the mappings between letters and meaning were completely arbitrary. At test, performance on naming tasks was better following training that emphasised the phonological rather than the semantic mappings, whereas performance on semantic tasks was similar in the two conditions...
May 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/29736556/-correct-positioning-of-central-venous-catheters-in-pediatrics-are-current-formulae-really-useful
#11
REVIEW
C Cleff, M Boensch, F Eifinger, J Hinkelbein
BACKGROUND: Correct positioning of a central venous catheter (CVC) tip in pediatric patients is very important. Malpositioning may lead to direct complications, such as arrhythmia and increase the risk of thrombosis, infections, valve failures or pericardial tamponade. OBJECTIVE: The aim of this review was to identify and summarize published formulae for the correct positioning of the CVC tip in children and to discuss the benefits of these formulae for the daily routine...
May 7, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29722835/catheter-related-bloodstream-infections-in-patients-with-intestinal-failure-receiving-home-parenteral-support-risks-related-to-a-catheter-salvage-strategy
#12
Siri Tribler, Christopher F Brandt, Kristian A Fuglsang, Michael Staun, Per Broebech, Claus E Moser, Thomas Scheike, Palle B Jeppesen
Background: In intestinal failure (IF) patients receiving home parenteral support (HPS), catheter-related bloodstream infections (CRBSIs) frequently result in replacement of their tunneled central venous catheters (CVCs), which may lead to future loss of central venous access. Objective: This observational study investigated the consequences of a catheter-salvage strategy related to CRBSIs. Design: All CRBSIs from 2002 to 2016 in the Copenhagen IF and microbiological databases were retrospectively analyzed...
May 1, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29720244/administration-of-taurolidine-citrate-lock-solution-for-prevention-of-central-venous-catheter-infection-in-adult-neutropenic-haematological-patients-a-randomised-double-blinded-placebo-controlled-trial-taurcat
#13
C Gudiol, S Nicolae, C Royo-Cebrecos, M Aguilar-Guisado, I Montero, C Martín-Gandul, M Perayre, D Berbel, M Encuentra, M Arnan, J M Cisneros-Herreros, J Carratalà
BACKGROUND: Catheter-related bloodstream infection (CRBSI) is one of the most frequent complications in patients with cancer who have central venous catheters (CVCs) implanted and is associated with substantial morbidity and mortality. Taurolidine is a non-antibiotic agent with broad-spectrum antimicrobial activity, which has been used as a lock solution to prevent CRBSI in some settings. However, little is known about its usefulness in high-risk adult neutropenic patients with cancer...
May 2, 2018: Trials
https://www.readbyqxmd.com/read/29714523/design-of-brand-names-of-medicines-considering-subjects-preferences
#14
Carla Maria Batista Ferreira Pires, Afonso Cavaco
BACKGROUND: Only recently, regulations on the names of medicines were developed. Regulations are mainly focused on avoiding the approval of medicine names that may be confusing to others. Furthermore, legal requirements do not include testing for human factors, such as potential users' preferences. STUDY AIMS: To develop a set of new brand names of medicines, to determine subjects' preferred names, and to evaluate if the linguistic features of these names were related to subjects' preferences...
March 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29701407/creative-vascular-access-construction-in-same-patient
#15
Pedro Pinto Sousa, Paulo Almeida, Pedro Sá Pinto, Rui Almeida
INTRODUCTION: Creating and maintaining a functional vascular access(VA) is a critical factor in the survival of a dialysis patient. However, it will not function forever, implying a creative attitude from the vascular surgeon either to maintain its functionality or built a new one wherever possible, being it autologous or synthetic. METHODS: Describe the VA history of a 59years-old male with morbid obesity and end-stage chronic kidney disease. RESULTS: His VA construction started in2012 with failed attempts in both forearms until a functional brachiocephalic artery-venous fistula(AVF) in the right upper limb was achieved, but was deemed to ligation as severe venous hypertension secondary to central venous disease related to CVC use...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29696130/intraperitoneally-located-tip-of-femoral-vein-catheter-clinical-suspicion-for-avoidance-of-unnecessary-laparotomy
#16
Hamed Shafiee, Saeid Safari, Reza Aminnejad
Central venous catheterization is a common procedure in critical care and trauma patients. Complications are not rare and in some studies more than 15% incidence has been reported (1). Femoral vein is one of the commonest site for this purpose yet it carries complications, such as infection and misplacement. The current study reports an unexpected secondary malposition of right femoral CVC in the peritoneal cavity. It was concluded that in any case of acute abdominal issues, following insertion of femoral venous catheter, evaluation of catheter misplacement by the means of contrast injection through it can be helpful for better diagnosis, and may help avoid unnecessary surgical interventions...
December 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/29693941/pre-anesthetic-whole-body-point-of-care-ultrasonography
#17
Takeshi Nomura, Itaru Watanabe
Point-of-care ultrasonography has become widely used in diagnosis and managements of patients. In the field of anesthesiology, ultrasound guided nerve blocks and central venous catheterization (CVC), and transesophageal echocardiography (TEE) have become popular. Now, ultrasound devices are familiar to anesthesiologists. In pre-anesthetic patient risk evaluation, the sonographic results of transthoracic echocardiography (TTE) or the examination of deep venous thrombus are often helpful for anesthesia planning...
May 2017: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/29688778/influence-of-immune-mediated-hemolytic-anemia-on-flow-velocities-in-the-portal-vein-and-caudal-vena-cava-measured-by-use-of-pulsed-wave-doppler-ultrasonography-in-dogs
#18
Rachel Policelli Smith, Amy M Koenigshof, Daniel J Smith, Phillip R Strom, Nathan C Nelson
OBJECTIVE To compare blood flow velocities of the portal vein (PV) and caudal vena cava (CVC) measured by use of pulsed-wave Doppler ultrasonography in clinically normal dogs and dogs with primary immune-mediated hemolytic anemia (IMHA). ANIMALS 11 client-owned dogs admitted to a veterinary teaching hospital for management of primary IMHA and 21 staff- or student-owned clinically normal dogs. PROCEDURES Flow velocities in the PV and CVC at the porta hepatis were evaluated in conscious unsedated dogs with concurrent ECG monitoring; evaluations were performed before dogs with IMHA received heparin or blood transfusions...
May 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29677980/a-method-for-developing-standard-patient-education-program
#19
Carolina Bryne Lura, Sophie Misser Pallesgaard Hauch, Kirstine Rosenbeck Gøeg, Louise Pape-Haugaard
In Denmark, patients being treated on Haematology Outpatients Departments get instructed to self-manage their blood sample collection from Central Venous Catheter (CVC). However, this is a complex and risky procedure, which can jeopardize patient safety. The aim of the study was to suggest a method for developing standard digital patient education programs for patients in self-administration of blood samples drawn from CVC. The Design Science Research Paradigm was used to develop a digital patient education program, called PAVIOSY, to increase patient safety during execution of the blood sample collection procedure by using videos for teaching as well as procedural support...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29668770/syllabic-patterns-in-typical-and-atypical-phonological-development-ultrasonographic-analysis
#20
Aline Mara de Oliveira Vassoler, Larissa Cristina Berti
Objective The present study aims to compare the production of syllabic patterns of the CVC and CV types performed by Brazilian children with typical and atypical phonological development through ultrasonography of tongue. Methods Ten children (five with typical and with five atypical phonological development) recorded nine pairs of words from the syllables: CCV and CV. The images and audios were captured simultaneously by the Articulate Assistant Advanced software. The data were submitted to perceptive analysis and ultrasonographic articulatory analysis (the area between the tip and the blade of the tongue)...
2018: CoDAS
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