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https://www.readbyqxmd.com/read/29775175/hiv-induced-matrix-metalloproteinase-9-activation-through-mitogen-activated-protein-kinase-signalling-promotes-hsv-1-cell-to-cell-spread-in-oral-epithelial-cells
#1
Irna Sufiawati, Sharof M Tugizov
We have shown that cell-free HIV-1 and viral proteins tat and gp120 activate mitogen-activated protein kinases (MAPKs) in tonsil epithelial cells, disrupting their tight and adherens junctions. This causes liberation of the HSV-1 receptor nectin-1 from assembled adherens junctions, leading to promotion of HSV-1 infection and spread. In the present study, we show that HIV-associated activation of MAPK leads to upregulation of transcription factor NF-κB and matrix metalloproteinase-9 (MMP-9). This induces the disruption of tight and adherens junctions, increasing HSV-1 cell-to-cell spread...
May 18, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29775007/-clinical-observation-of-partial-resection-and-drainage-of-abscess-around-tonsils-on-the-upper-pole-of-the-tonsils
#2
C C Chen, Y W Chen, J W Zheng
No abstract text is available yet for this article.
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29773422/a-novel-homozygous-abca1-variant-in-an-asymptomatic-man-with-profound-hypoalphalipoproteinemia
#3
Yaser Carcora, Robert D Brook, Linda Farhat, Cristen J Willer, Melvyn Rubenfire, Daniel Seung Kim
Low high-density lipoprotein cholesterol (HDL-C) can be caused by several acquired secondary causes as well as primary genetic disorders. However, only a few conditions are associated with profoundly reduced levels below 10 mg/dL. We present an unusual case of a healthy man with severely decreased HDL-C because of a novel homozygous variant causing a Proline > Arginine amino acid change at position 1312 in the ATP-binding cassette transporter A1 gene. Homozygous variations in ATP-binding cassette transporter A1 typically cause Tangier disease, a rare autosomal recessive condition linked with several other abnormalities (eg, enlarged discolored tonsils)...
April 21, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29773199/health-risk-assessment-of-arsenic-in-realgar-and-niuhuangjiedu-tablets-based-on-pharmacokinetic-study
#4
Xiao Wu, Shanhu Wu, Yuexin Liu, Rong Guan, Fangmei Liang, Min Song, Taijun Hang
NiuHuangJieDu Tablets (NHJDT), a popular realgar (As4 S4 ) containing patented traditional Chinese medicine (TCM), is widely used in the treatment of acute tonsillitis, pharyngitis, periodontitis and mouth ulcer. However, arsenic is considered as one of the most toxic elements, leading to growing concerns about the quality and safety of realgar-containing TCMs recently. In this study, health risk assessment of arsenic in realgar and NHJDT was conducted through oral administration of both substances to rats with single and multiple doses, respectively...
July 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29772595/-case-report-metamizole-induced-agranulocytosis
#5
Falk A Gonnert, Winfried Meißner
Metamizole is primarily used for severe perioperative pain, acute injury and colic, and cancer pain. For other acute/chronic forms of pain and high fever, it should only be used if unresponsive to other agents. Metamizole should not be used for middle and low pain. Oral application should be preferred. A contraindication for metamizole is leukopenia. Clinical signs for agranulocytosis are fever, tonsillitis and aphthous stomatitis.
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29771046/-clinical-evaluation-value-of-visual-analogue-scale-combined-with-c-reactive-protein-for-the-prognosis-of-peritonsillar-abscess
#6
W L Liu, C F Chen, D L Lu, L F Guo
Objective: The aim of this study is to investigate the clinical value of visual analogue scale combined with serum C-reactive protein in evaluating the prognosis of peritonsillar abscess. Method: Thirty-one patients be hospitalized with peritonsillar abscess were enrolled in this study, who were treated by puncture and antibiotic from January 2016 to February 2017. VAS and CRP level were detected on the 1, 3, 5 day of hospitalization for all the patients. Result: Twenty-five patients were cured after 5 days...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29767829/homeopathy-in-the-age-of-antimicrobial-resistance-is-it-a-viable-treatment-for-upper-respiratory-tract-infections
#7
Alison Fixsen
BACKGROUND:  Acute upper respiratory tract infections (URTIs) and their complications are the most frequent cause of antibiotic prescribing in primary care. With multi-resistant organisms proliferating, appropriate alternative treatments to these conditions are urgently required. Homeopathy presents one solution; however, there are many methods of homeopathic prescribing. This review of the literature considers firstly whether homeopathy offers a viable alternative therapeutic solution for acute URTIs and their complications, and secondly how such homeopathic intervention might take place...
May 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29766459/cognitive-functioning-in-chiari-malformation-type-i-without-posterior-fossa-surgery
#8
Maitane García, Esther Lázaro, Juan Francisco López-Paz, Oscar Martínez, Manuel Pérez, Sarah Berrocoso, Mohammad Al-Rashaida, Imanol Amayra
Chiari Malformation type I (CM-I) is a neurological disorder characterized by a displacement of the cerebellar tonsils through the foramen magnum into the spinal canal. Most research has focused on physical symptomatology but few studies include neuropsychological examinations. Moreover, although current research highlights the involvement of the cerebellum on higher cognitive functions, little is known about cognitive consequences associated with CM-I. The aim of this study is to analyze cognitive functioning between 39 CM-I patients and 39 healthy controls, matched by gender, age and years of education...
May 15, 2018: Cerebellum
https://www.readbyqxmd.com/read/29765997/effects-of-oral-probiotic-feeding-on-toll-like-receptor-gene-expression-of-the-chicken-s-cecal-tonsil
#9
Fatemeh Asgari, Reza Falak, Shahram Teimourian, Babak Pourakbari, Salimeh Ebrahimnezhad, Mehdi Shekarabi
Background: It was proposed that probiotics may influence immune system through direct or indirect exposure. Direct exposure is mostly mediated by surface receptors. Toll-like receptors (TLRs) are conserved molecular sensors which could be triggered via some pathogen associated structures, hence, modulate the immune responses. This study was conducted to elucidate the impact of lactobacillus acidophilus as a common probiotic on the expression level of TLRs in the chicken's cecal tonsil...
April 2018: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29765511/immunohistochemical-analysis-of-rhamm-expression-in-normal-and-neoplastic-human-tissues-a-cell-cycle-protein-with-distinctive-expression-in-mitotic-cells-and-testicular-germ-cells
#10
Yao-Tseng Chen, Zhengming Chen, Yi-Chieh Nancy Du
Expression of Receptor for Hyaluronic Acid Mediated Motility (RHAMM) increases cellular motility and RHAMM overexpression promotes invasive phenotype and metastasis of cancer cells. RHAMM has been suggested as a biomarker for poor prognosis in several tumor types, including lung, breast, colorectal, gastric, pancreatic ductal, and ovarian cancers. RNA studies showed restricted RHAMM expression in normal tissues, but its protein expression data in tissues were limited. In light of its potential as a prognostic marker and a therapeutic target, we performed immunohistochemical analysis to systematically characterize RHAMM expression in normal and neoplastic human tissues...
April 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29764740/are-computed-tomography-3d-measurements-of-the-upper-airways-in-mouth-breathing-children-in-agreement-with-the-ent-clinical-diagnosis-of-obstruction
#11
Bruno César Ladeira Vidigal, Carolina Morsani Mordente, Paula Loureiro Cheib, Flávio Ricardo Manzi, Letícia Paiva Franco, Helena Maria Gonçalves Becker, Bernardo Quiroga Souki
INTRODUCTION: Imaging studies have hystorically been used to support the clinical otorhinolaryngological evaluation of the upper respiratory tract for the diagnosis of obstructive causes of oral breathing. OBJECTIVE: The objective of this study was to compare 3D volumetric measurements of nasal cavity, nasopharynx and oropharynx of obstructed mouth-breathing children with measurements of non-obstructed mouth-breathing children. METHODS: This retrospective study included 25 mouth-breathing children aged 5-9 years evaluated by otorhinolaryngological clinical examination, flexible nasoendoscopy and full-head multi-slice computed tomography...
March 11, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29760212/a-model-of-persistent-salmonella-infection-salmonella-pullorum-modulates-the-immune-response-of-the-chicken-from-a-th17-towards-a-th2-type-response
#12
Ying Tang, Neil Foster, Michael A Jones, Paul A Barrow
Salmonella enterica infection affects a wide range of animals and human and a small number of serovars cause typhoid-like infections, one characteristic of which is persistent infection in convalescents. The avian specific serovar S Pullorum produces systemic disease in young chickens which is followed by a carrier state in convalescent birds leading to infection of the ovary at sexual maturity and vertical transmission. However, the immunological basis of the persistent infection remains unclear. S. Enteritidis is taxonomically closely related but does not show this characteristic...
May 14, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29757565/-the-development-of-techniques-served-to-widen-the-lateral-velopharyngeal-space-for-treating-osahs
#13
REVIEW
Jing Yan Huang, Xiang Min Zhang
Since Fujita first described uvulopalatopharyngoplasty(UPPP)in 1981,UPPP and its modified procedures have been widely used to treat obstructive sleep apnea and hyponea syndrome(OSAHS).However,despite of its wide application,the success rates was uncertain,ranging from 20% to 80%,with patients of varing Friedman stages.It is well known that the principle of UPPP is to remove the redundant tissue of palate,elongated uvula and hypertrophic tonsils in order to widen the anteroposterior space at the level of palate...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29749883/rapid-sequence-brain-magnetic-resonance-imaging-for-chiari-i-abnormality
#14
James Pan, Jennifer L Quon, Eli Johnson, Bryan Lanzman, Anjeza Chukus, Allen L Ho, Michael S B Edwards, Gerald A Grant, Kristen W Yeom
OBJECTIVE Fast magnetic resonance imaging (fsMRI) sequences are single-shot spin echo images with fast acquisition times that have replaced CT scans for many conditions. Introduced as a means of evaluating children with hydrocephalus and macrocephaly, these sequences reduce the need for anesthesia and can be more cost-effective, especially for children who require multiple surveillance scans. However, the role of fsMRI has yet to be investigated in evaluating the posterior fossa in patients with Chiari I abnormality (CM-I)...
May 11, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29748549/genotype-i-of-japanese-encephalitis-virus-virus-like-particles-elicit-sterilizing-immunity-against-genotype-i-and-iii-viral-challenge-in-swine
#15
Yi-Chin Fan, Jo-Mei Chen, Jen-Wei Lin, Yi-Ying Chen, Guan-Hong Wu, Kuan-Hsuan Su, Ming-Tang Chiou, Shang-Rung Wu, Ji-Hang Yin, Jiunn-Wang Liao, Gwong-Jen J Chang, Shyan-Song Chiou
Swine are a critical amplifying host involved in human Japanese encephalitis (JE) outbreaks. Cross-genotypic immunogenicity and sterile protection are important for the current genotype III (GIII) virus-derived vaccines in swine, especially now that emerging genotype I (GI) JE virus (JEV) has replaced GIII virus as the dominant strain. Herein, we aimed to develop a system to generate GI JEV virus-like particles (VLPs) and evaluate the immunogenicity and protection of the GI vaccine candidate in mice and specific pathogen-free swine...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748399/complete-genome-sequences-of-10-yersinia-pseudotuberculosis-isolates-recovered-from-wild-boars-in-germany
#16
Marie Reinhardt, Jens A Hammerl, Stefan Hertwig
We report here the draft genome sequences of 10 Yersinia pseudotuberculosis isolates recovered from tonsils of wild boars hunted between 2015 and 2016 in Germany. Whole-genome sequencing and bioinformatic analyses were performed to assess the diversity of Y. pseudotuberculosis , which may result in human infections caused by the consumption of game meat.
May 10, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29748373/slan-monocytes-and-macrophages-mediate-cd20-dependent-b-cell-lymphoma-elimination-via-adcc-and-adcp
#17
William Vermi, Alessandra Micheletti, Giulia Finotti, Cristina Tecchio, Federica Calzetti, Sara Costa, Mattia Bugatti, Stefano Calza, Claudio Agostinelli, Stefano Pileri, Piera Balzarini, Alessandra Tucci, Giuseppe Rossi, Lara Furlani, Giuseppe Todeschini, Alberto Zamò, Fabio Facchetti, Luisa Lorenzi, Silvia Lonardi, Marco A Cassatella
Terminal tissue differentiation and function of slan+ monocytes in cancer is largely unexplored. Our recent studies demonstrated that slan+ monocytes differentiate into a distinct subset of dendritic cells (DC) in human tonsils and that slan+ cells colonize metastatic carcinoma-draining lymph nodes. Herein, we report by retrospective analysis of multi-institutional cohorts that slan+ cells infiltrate various types of non-Hodgkin lymphomas (NHL), particularly the diffuse large B-cell lymphoma (DLBCL) group, including the most aggressive, nodal and extra-nodal, forms...
May 10, 2018: Cancer Research
https://www.readbyqxmd.com/read/29748171/pautrier-like-microabscesses-in-the-tonsil
#18
Ikuo Matsuda, Seiichi Hirota
No abstract text is available yet for this article.
May 10, 2018: Blood
https://www.readbyqxmd.com/read/29747315/-value-of-pet-ct-in-the-prognosis-of-extranodal-nk-t-cell-lymphoma
#19
G H Dong, Y Li, H F Wan, C Y He, L Yang, J W Wang, L P Gong, Y H Zhao, Z F Gao, H G Liu
Objective: To explore the value of Positron-Emission Tomography/Computed Tomography (PET/CT) in the prognosis of extranodal NK/T cell lymphoma. Methods: The patients of NK/T cell lymphoma diagnosed from January 2007 to July 2016 in Department of Pathology of Beijing Tongren Hospital were enrolled in this study. Seventy-two in-hospital patients were examined on the invasion of adjecent tissue or organ by PET/CT. The PET/CT results were analyzed retrospectively. Kaplan-Meier method was used to analyze the prognostic value of the positive results by PET/CT on overall survival (OS)...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29734222/progressive-lentivirus-infection-induces-natural-killer-cell-receptor-expressing-b-cells-in-the-gastrointestinal-tract
#20
Cordelia Manickam, Chiadika Nwanze, Daniel R Ram, Spandan V Shah, Scott Smith, Rhianna Jones, Brady Hueber, Kyle Kroll, Valerie Varner, Paul Goepfert, Stephanie Jost, R Keith Reeves
OBJECTIVE: Recently, a seemingly novel innate immune cell subset bearing features of natural killer and B cells was identified in mice. So-called NKB cells appear as first responders to infections, but whether this cell population is truly novel or is in fact a subpopulation of B cells and exists in higher primates remains unclear. The objective of this study was to identify NKB cells in primates and study the impact of HIV/SIV infections. DESIGN AND METHODS: NKB cells were quantified in both naïve and lentivirus infected rhesus macaques and humans by excluding lineage markers (CD3, CD127), and positive Boolean gating for CD20, NKG2A/C and/or NKp46...
May 3, 2018: AIDS
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