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https://www.readbyqxmd.com/read/28454464/metastasis-from-a-primary-hepatic-angiosarcoma-to-the-colon-a-case-report-and-literature-review
#1
Yukako Mokutani, Taishi Hata, Yuichiro Miyake, Hideki Kuroda, Hidekazu Takahashi, Naotsugu Haraguchi, Junichi Nishimura, Tsunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Masaki Mori
Primary hepatic angiosarcoma is a rare type of tumor with a poor prognosis. To the best of our knowledge, curative surgery of a metastatic gastrointestinal angiosarcoma from a hepatic angiosarcoma has not been reported previously. In the present report, a case of colonic metastasis from a primary hepatic angiosarcoma is discussed. A rapidly growing mass was identified in the liver of an 84-year-old Japanese male who underwent a subsegmentectomy of the liver. Microscopic examination determined that the mass was an angiosarcoma composed of sheets of spindle cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454263/investigation-of-the-cytotoxicity-apoptosis-and-pharmacokinetics-of-raddeanin-a
#2
Guiying Gu, Huanhuan Qi, Tianyue Jiang, Bo Ma, Zheng Fang, Hong Xu, Qi Zhang
Raddeanin A, one of the triterpenoid saponins extracted from Anemone raddeana rhizome of the Ranunculaceae family, has demonstrated the ability to inhibit the growth of human hepatic and gastric cancer cells. However, the effects of Raddeanin A on human colon cancer cells have not been investigated extensively. The present study aimed to examine the antiproliferative and apoptosis-inducing effects of Raddeanin A on the HCT-116 human colon cancer cell line in vitro, and evaluate the pharmacokinetic and biodistribution properties of Raddeanin A in mice following a single oral administration...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454262/aberrant-klk4-gene-promoter-hypomethylation-in-pediatric-hepatoblastomas
#3
Baihui Liu, Ximao Cui, Shan Zheng, Kuiran Dong, Rui Dong
DNA methylation has a crucial role in cancer biology and has been recognized as an activator of oncogenes and inactivator of tumor suppressor genes, both of which are mechanisms for tumorigenesis. Kallikrein-related peptidase 4 (KLK4), has been suggested to be an oncogene in various types of cancer. The aim of the present study was to assess the DNA methylation patterns of the KLK4 gene in cancerous samples harvested from patients with hepatoblastoma (HB). KLK4 mRNA expression levels were detected using reverse transcription-quantitative polymerase chain reaction and assessed its DNA methylation patterns using high-throughput mass spectrometry on a matrix-assisted laser desorption/ionization time-of-flight mass array...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454235/metabolic-profiling-of-hepatitis-b-virus-related-hepatocellular-carcinoma-with-diverse-differentiation-grades
#4
Lei Zhang, Ya Huang, Mingjian Lian, Zhijuan Fan, Yaqiong Tian, Yufan Wang, Hua Kang, Shuang Liu, Shuye Liu, Tong Li, Zhongqiang Shan
The most effective diagnostic tool for the majority of hepatocellular carcinoma (HCC) patients is determining the differentiation grade of their tumors. However liver biopsies, which are currently the most effective way of determining tumor differentiation grade, have several limitations. The present study was designed to select serum characteristic metabolites that correlate with the differentiation grades of hepatitis B virus (HBV)-related HCC, and so could be used in the clinic as a non-invasive method of differentiating patients with different grades of HCC...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28448863/multi-sited-hydatid-cystic-disease-with-muscular-involvement-in-a-young-female-a-case-report-from-syria
#5
Hazem Aljasem, Mohammad Almess, Monzer Bakgagi
INTRODUCTION: Hydatidosis is a unique disease caused by a tapeworm called Echinococcus granulosus. Musculoskeletal involvement with hydatid cystic disease accounts for less than 5% of all cases. The main purpose of this study is to present a case of multi-sited hydatid cystic disease and how to manage it. PRESENTATION OF CASE: Here we present a case of 14-year-old girl complained of a gradually enlarging mass on her left shoulder with a final diagnosis of triple-sited hydatid cystic disease including the right lung, the left trapezius muscle and the liver...
April 19, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28447322/successful-hepatectomy-for-hepatic-abscess-with-chronic-granulomatous-disease-a-case-report
#6
Ryo Muranushi, Makoto Suzuki, Kenichiro Araki, Norio Kubo, Sayaka Otake, Yutaka Nishida, Takashi Ishige, Hirokazu Arakawa, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Chronic granulomatous disease (CGD), a rare inherited disorder, is characterized by impaired ability of phagocytic cells to kill certain bacteria and fungi. Although liver abscess is a common manifestation of CGD, its optimal management in these patients is unknown. Here, we present a case of successful hepatectomy for hepatic abscess in a patient with CGD. CASE PRESENTATION: An adolescent patient with previously diagnosed CGD presented to the pediatrics department of our institution with fever...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28443906/the-enhanced-anti-obesity-effect-and-reduced-gastric-mucosa-irritation-of-capsaicin-loaded-nanoemulsions
#7
Muwen Lu, Yong Cao, Chi-Tang Ho, Qingrong Huang
Capsaicin (CAP), the major active component of chili peppers, is known to have thermogenic and weight-loss potential. The aim of this study was to investigate the anti-obesity effects of capsaicin-loaded nanoemulsions (C-NE) on male Sprague Dawley (SD) rats treated with a high-fat diet (HFD). The food grade C-NE was prepared using capsaicin, medium chain triacylglycerols (MCT) (Neobee 1053), sucrose stearate S-370, Tween 80 and distilled water with an emulsion droplet size of 168 nm and a capsaicin loading of 80...
April 26, 2017: Food & Function
https://www.readbyqxmd.com/read/28443804/25-oh-d-levels-in-relation-to-gender-overweight-insulin-resistance-and-inflammation-in-a-cross-sectional-cohort-of-northern-italian-workers-evidence-in-support-of-preventive-health-care-programs
#8
Luisella Vigna, Letizia Cassinelli, Amedea Silvia Tirelli, Irene Felicetta, Filomena Napolitano, Laura Tomaino, Michela Mutti, Claudia Eleonora Barberi, Luciano Riboldi
OBJECTIVE: In recent years, the welfare of workers and the prevention of chronic disabling diseases has become a topic of great interest. This study investigates serum levels of total 25-hydroxyvitamin D (25(OH)D) in a cohort of overweight-obese and insulin-resistant northern Italian indoor workers in apparent good health followed a nutritional education program. METHODS: An observational cross-sectional study on 385 patients (females = 291, males = 94), age range 18-69 years and body mass index (BMI) > 25 kg/m(2), was performed at the Department of Occupational Medicine Milan, Italy, latitude 45...
April 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28443702/turmeric-supplementation-improves-serum-glucose-indices-and-leptin-levels-in-patients-with-nonalcoholic-fatty-liver-diseases
#9
Roya Navekar, Maryam Rafraf, Aida Ghaffari, Mohammad Asghari-Jafarabadi, Manouchehr Khoshbaten
OBJECTIVE: Insulin and leptin resistance are important risk factors for non-alcoholic fatty liver disease (NAFLD). There is limited evidence regarding the effects of turmeric on NAFLD. The aim of this study was to investigate the effects of turmeric supplementation on glycemic status and serum leptin levels in patients with NAFLD. METHODS: This double-blind randomized controlled clinical trial was conducted on 46 patients with NAFLD (21males and 25 females) aged 20-60 years old and body mass index (BMI) between 24...
April 26, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28443563/nonthrombotic-pulmonary-embolism-due-to-liver-hydatic-cyst-a-case-report
#10
Ahmet Şahpaz, Azem İrez, Hatice Gülbeyaz, Mustafa Talip Şener, Ahmet Nezih Kök
BACKGROUND: A nonthrombotic pulmonary embolism is defined as embolization to the pulmonary circulation. It may be caused by microorganisms, foreign bodies, different cell types or gas in the pulmonary circulation. Nonthrombotic emboli may cause a severe inflammatory reaction, both in the systemic and pulmonary circulation, as well as in the lungs. Pulmonary hydatid cyst-induced embolization is a rare complication of heart or liver hydatid cysts. CASE REPORT: We describe the fatal case of a 15-year-old boy without any known prior illness who was admitted to the hospital after feeling unwell and dropping to the ground while playing ball...
April 13, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28443337/inhaled-nanoparticles-accumulate-at-sites-of-vascular-disease
#11
Mark R Miller, Jennifer B Raftis, Jeremy P Langrish, Steven G McLean, Pawitrabhorn Samutrtai, Shea P Connell, Simon Wilson, Alex T Vesey, Paul H B Fokkens, A John F Boere, Petra Krystek, Colin J Campbell, Patrick W F Hadoke, Ken Donaldson, Flemming R Cassee, David E Newby, Rodger Duffin, Nicholas L Mills
The development of engineered nanomaterials is growing exponentially, despite concerns over their potential similarities to environmental nanoparticles that are associated with significant cardiorespiratory morbidity and mortality. The mechanisms through which inhalation of nanoparticles could trigger acute cardiovascular events are emerging, but a fundamental unanswered question remains: Do inhaled nanoparticles translocate from the lung in man and directly contribute to the pathogenesis of cardiovascular disease? In complementary clinical and experimental studies, we used gold nanoparticles to evaluate particle translocation, permitting detection by high-resolution inductively coupled mass spectrometry and Raman microscopy...
April 26, 2017: ACS Nano
https://www.readbyqxmd.com/read/28442524/extrauterine-adenomyoma-of-the-liver-in-a-50-year-old-female-with-pelvic-endometriosis
#12
Nidhi Tandon, Josh Showalter, Sadia Sultana, Bihong Zhao, Songlin Zhang
Extrauterine adenomyomas are defined as circumscribed tumor-like masses consisting of smooth muscle tissue, endometrioid glands and stroma. They are extremely rare tumors and similar to their uterine counterparts. We report case of a 50 year old female with an extrauterine adenomyoma of the liver associated with pelvic endometriosis. To the best of our knowledge, only fifteen cases of extrauterine adenomyomas have been reported with only one previous case in the liver. This is the first case of extrauterine adenomyoma of the liver associated with pelvic endometriosis...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28442522/clinical-criteria-correlated-with-the-incidence-of-patients-with-non-alcoholic-fatty-liver-disease
#13
Kung Chien-Min, Liu Cheng-Chuan
GOALS: In this study, predictive panels were constructed and validated to recognize an individual with and without nonalcoholic fatty liver disease (NAFLD) based on clinical and biochemical criteria. METHODS: Two hundred and thirty six non-alcoholic adults with no chronic viral hepatitis history were recruited from a medical center in Taiwan in 2013. All subjects were examined for body mass index (BMI), abdominal ultrasonography, blood liver function tests (including alanine aminotransferase [ALT], aspartate aminotransferase [AST], gamma glutamyl transpeptidase [GGT]), blood lipids (total cholesterol [TC] and triglyceride [TG]) and blood glucose (BG) tests...
March 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/28442499/absorption-distribution-metabolism-and-excretion-of-the-oral-prostaglandin-d2-receptor-2-dp2-antagonist-fevipiprant-qaw039-in-healthy-volunteers-and-in-vitro
#14
David Pearson, H Markus Weiss, Yi Jin, Jan Jaap van Lier, Veit J Erpenbeck, Ulrike Glaenzel, Peter End, Ralph Woessner, Fabian Eggimann, Gian Camenisch
Fevipiprant is a novel oral prostaglandin D2 receptor 2 (DP2; also known as CRTh2) antagonist, which is currently in development for the treatment of severe asthma and atopic dermatitis. We investigated the absorption, distribution, metabolism, and excretion properties of fevipiprant in healthy subjects after a single 200 mg oral dose of [(14)C]-radiolabeled fevipiprant. Fevipiprant and metabolites were analyzed by liquid chromatography coupled to tandem mass spectrometry and radioactivity measurements, and mechanistic in vitro studies were performed to investigate clearance pathways and covalent plasma protein binding...
April 25, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28441753/coq10-deficiency-may-indicate-mitochondrial-dysfunction-in-cr-vi-toxicity
#15
Xiali Zhong, Xing Yi, Rita de Cássia da Silveira E Sá, Yujing Zhang, Kaihua Liu, Fang Xiao, Caigao Zhong
To investigate the toxic mechanism of hexavalent chromium Cr(VI) and search for an antidote for Cr(VI)-induced cytotoxicity, a study of mitochondrial dysfunction induced by Cr(VI) and cell survival by recovering mitochondrial function was performed. In the present study, we found that the gene expression of electron transfer flavoprotein dehydrogenase (ETFDH) was strongly downregulated by Cr(VI) exposure. The levels of coenzyme 10 (CoQ10) and mitochondrial biogenesis presented by mitochondrial mass and mitochondrial DNA copy number were also significantly reduced after Cr(VI) exposure...
April 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441380/comparison-of-general-obesity-and-measures-of-body-fat-distribution-in-older-adults-in-relation-to-cancer-risk-meta-analysis-of-individual-participant-data-of-seven-prospective-cohorts-in-europe
#16
Heinz Freisling, Melina Arnold, Isabelle Soerjomataram, Mark George O'Doherty, José Manuel Ordóñez-Mena, Christina Bamia, Ellen Kampman, Michael Leitzmann, Isabelle Romieu, Frank Kee, Konstantinos Tsilidis, Anne Tjønneland, Antonia Trichopoulou, Paolo Boffetta, Vassiliki Benetou, H B As Bueno-de-Mesquita, José María Huerta, Hermann Brenner, Tom Wilsgaard, Mazda Jenab
BACKGROUND: We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal and postmenopausal breast) cancer incidence. METHODS: This is a meta-analysis of seven prospective cohort studies participating in the CHANCES consortium including 18 668 men and 24 751 women with a mean age of 62 and 63 years, respectively...
April 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28440522/-nutrition-management-in-obese-patients-with-type-2-diabetes-mellitus-after-laparoscopic-sleeve-gastrectomy
#17
Weihong Tang, Yuhua Chen, Meizhen Pan, Lihua Chen, Lele Zhang, Tingfeng Wang, Xiong Zhang, Peng Zhang, Chengzhu Zheng, Bo Yu
OBJECTIVE: To explore the value of nutrition management in obese patients with type 2 diabetes mellitus(T2DM) after laparoscopic sleeve gastrectomy(LSG). METHODS: Clinical data of 22 obese T2DM patients undergoing LSG from March 2013 to July 2015 in Fudan University Pudong Medical Center were collected. All the patients strictly followed the specialized instruction by nutritionists: diabetic and low calorie diet 3347.2 to 5020.8 kJ (800 to 1200 kcal) per day before the operation; low calorie liquid diet 2510...
April 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28440236/endoscopic-ultrasound-guided-fine-needle-aspiration-can-target-right-liver-mass
#18
Dongwook Oh, Dong-Wan Seo, Seung-Mo Hong, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Sung Koo Lee, Myung-Hwan Kim
BACKGROUND AND OBJECTIVES: Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has been established as a safe and accurate method for diagnosing and staging intra-abdominal mass. However, few studies investigated its feasibility, efficacy, and safety for targeting liver mass. We evaluated the efficacy and safety of EUS-FNA in patients with liver masses including the right lobe. PATIENTS AND METHODS: The technical feasibility, safety, and diagnostic yield were determined in 47 patients (30 in the left lobe and 17 in the right lobe) presenting with liver masses between September 2010 and February 2016...
March 2017: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28439569/the-obesity-paradox-in-kidney-disease-how-to-reconcile-it-with-obesity-management
#19
Kamyar Kalantar-Zadeh, Connie M Rhee, Jason Chou, S Foad Ahmadi, Jongha Park, Joline Lt Chen, Alpesh N Amin
Obesity, a risk factor for de novo chronic kidney disease (CKD), confers survival advantages in advanced CKD. This so-called obesity paradox is the archetype of the reverse epidemiology of cardiovascular risks, in addition to the lipid, blood pressure, adiponectin, homocysteine, and uric acid paradoxes. These paradoxical phenomena are in sharp contradistinction to the known epidemiology of cardiovascular risks in the general population. In addition to advanced CKD, the obesity paradox has also been observed in heart failure, chronic obstructive lung disease, liver cirrhosis, and metastatic cancer, as well as in the elderly...
March 2017: KI Reports
https://www.readbyqxmd.com/read/28438794/intraductal-oncocytic-papillary-neoplasm-a-benign-hepatic-cystic-neoplasm
#20
Angela Tong, Gregory Veillette, Alexandra Budhai, Anthony Gilet
A 61-year-old Asian man presented with severe right upper quadrant pain which had been worsening for several months. Laboratory results indicated elevated aspartate aminotransferase and alanine aminotransferase. The subsequent ultrasound, CT and MRI showed a large cystic mass with solid components and severe intrahepatic and extrahepatic biliary ductal dilatation. The mass was resected and pathology showed a well-demarcated mucinous cystic lesion with polygonal cells containing ovoid nuclei and abundant pink oncocytic cytoplasm...
April 24, 2017: BMJ Case Reports
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