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Cardiosphere derived cell

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https://www.readbyqxmd.com/read/28296006/intracoronary-allogeneic-cardiosphere-derived-stem-cells-are-safe-for-use-in-dogs-with-dilated-cardiomyopathy
#1
Michael Taylor Hensley, Junnan Tang, Kathleen Woodruff, Teresa Defrancesco, Sandra Tou, Christina M Williams, Mathew Breen, Kathryn Meurs, Bruce Keene, Ke Cheng
Cardiosphere-derived cells (CDCs) have been shown to reduce scar size and increase viable myocardium in human patients with mild/moderate myocardial infarction. Studies in rodent models suggest that CDC therapy may confer therapeutic benefits in patients with non-ischaemic dilated cardiomyopathy (DCM). We sought to determine the safety and efficacy of allogeneic CDC in a large animal (canine) model of spontaneous DCM. Canine CDCs (cCDCs) were grown from a donor dog heart. Similar to human CDCs, cCDCs express CD105 and are slightly positive for c-kit and CD90...
March 15, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28205406/potency-of-human-cardiosphere-derived-cells-from-patients-with-ischemic-heart-disease-is-associated-with-robust-vascular-supportive-ability
#2
Emma Harvey, Huajun Zhang, Pilar Sepúlveda, Sara P Garcia, Dominic Sweeney, Fizzah A Choudry, Delia Castellano, George N Thomas, Hassan Kattach, Romina Petersen, Derek J Blake, David P Taggart, Mattia Frontini, Suzanne M Watt, Enca Martin-Rendon
Cardiosphere-derived cell (CDC) infusion into damaged myocardium has shown some reparative effect; this could be improved by better selection of patients and cell subtype. CDCs isolated from patients with ischemic heart disease are able to support vessel formation in vitro but this ability varies between patients. The primary aim of our study was to investigate whether the vascular supportive function of CDCs impacts on their therapeutic potential, with the goal of improving patient stratification. A subgroup of patients produced CDCs which did not efficiently support vessel formation (poor supporter CDCs), had reduced levels of proliferation and increased senescence, despite them being isolated in the same manner and having a similar immunophenotype to CDCs able to support vessel formation...
February 16, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28202059/cardiosphere-derived-cells-do-not-improve-cardiac-function-in-rats-with-cardiac-failure
#3
Taís Hanae Kasai-Brunswick, Andréa Rodrigues da Costa, Raiana Andrade Quintanilha Barbosa, Bruna Farjun, Fernanda Cristina Paccola Mesquita, Danúbia Silva Dos Santos, Isalira Peroba Ramos, Grazielle Suhett, Guilherme Visconde Brasil, Sandro Torrentes da Cunha, José Oscar R Brito, Juliana do Amaral Passipieri, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho
BACKGROUND: Heart failure represents an important public health issue due to its high costs and growing incidence worldwide. Evidence showing the regenerative potential of postmitotic heart tissue has suggested the existence of endogenous cardiac stem cells in adult hearts. Cardiosphere-derived cells (CDC) constitute a candidate pool of such cardiac stem cells. Previous studies using acute myocardial infarction (MI) models in rodents demonstrated an improvement in cardiac function after cell therapy with CDC...
February 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28192031/neural-crest-stem-cells-can-differentiate-to-a-cardiomyogenic-lineage-with-an-ability-to-contract-in-response-to-pulsed-infrared-stimulation
#4
Jordan M Greenberg, Vicente Lumbreras, Daniel Pelaez, Suhrud M Rajguru, Herman S Cheung
INTRODUCTION: Cellular cardiomyoplasty has rapidly risen to prominence in the clinic following a myocardial infarction; however, low engraftment of transplanted cells limits the therapeutic benefit to these procedures. Recently, lineage-specific stem cells differentiated into cardiomyocytes have gained much attention to assist in the repair of an injured heart tissue; however, questions regarding the ideal cell source remain. In the present study, we have identified a source that is easy to extract stem cells from and show that the cells present have a high plasticity toward the cardiomyogenic lineage...
October 2016: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28167565/y-rna-fragment-in-extracellular-vesicles-confers-cardioprotection-via-modulation-of-il-10-expression-and-secretion
#5
Linda Cambier, Geoffrey de Couto, Ahmed Ibrahim, Antonio K Echavez, Jackelyn Valle, Weixin Liu, Michelle Kreke, Rachel R Smith, Linda Marbán, Eduardo Marbán
Cardiosphere-derived cells (CDCs) reduce myocardial infarct size via secreted extracellular vesicles (CDC-EVs), including exosomes, which alter macrophage polarization. We questioned whether short non-coding RNA species of unknown function within CDC-EVs contribute to cardioprotection. The most abundant RNA species in CDC-EVs is a Y RNA fragment (EV-YF1); its relative abundance in CDC-EVs correlates with CDC potency in vivo Fluorescently labeled EV-YF1 is actively transferred from CDCs to target macrophages via CDC-EVs...
March 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28166288/correction-cardiosphere-derived-cells-facilitate-heart-repair-by-modulating-m1-m2-macrophage-polarization-and-neutrophil-recruitment
#6
Al Shaimaa Hasan, Lan Luo, Chen Yan, Tian-Xia Zhang, Yoshishige Urata, Shinji Goto, Safwat A Mangoura, Mahmoud H Abdel-Raheem, Shouhua Zhang, Tao-Sheng Li
[This corrects the article DOI: 10.1371/journal.pone.0165255.].
2017: PloS One
https://www.readbyqxmd.com/read/28158410/exosomes-secreted-by-cardiosphere-derived-cells-reduce-scarring-attenuate-adverse-remodelling-and-improve-function-in-acute-and-chronic-porcine-myocardial-infarction
#7
Romain Gallet, James Dawkins, Jackelyn Valle, Eli Simsolo, Geoffrey de Couto, Ryan Middleton, Eleni Tseliou, Daniel Luthringer, Michelle Kreke, Rachel R Smith, Linda Marbán, Bijan Ghaleh, Eduardo Marbán
No abstract text is available yet for this article.
January 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28129786/metformin-promotes-the-survival-of-transplanted-cardiosphere-derived-cells-thereby-enhancing-their-therapeutic-effect-against-myocardial-infarction
#8
Rongchuan Yue, Wenbin Fu, Xiang Liao, Cong Lan, Qiao Liao, Liangpeng Li, Dezhong Yang, Xuewei Xia, Xiongwen Chen, Chunyu Zeng, Wei Eric Wang
BACKGROUND: Transplantation of cardiosphere-derived cells (CDCs) has been shown to exert a therapeutic effect in patients with myocardial infarction (MI). However, poor survival of transplanted CDCs limits their beneficial effect. Metformin (MET) activates AMP-activated protein kinase (AMPK) which is associated with cell survival. The aim of this study is to determine whether MET improves CDC survival in the transplantation microenvironment and enhances the therapeutic effect of CDC transplantation against MI...
January 28, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28115549/a-discrete-in-continuous-mathematical-model-of-cardiac-progenitor-cells-formation-and-growth-as-spheroid-clusters-cardiospheres
#9
Ezio Di Costanzo, Alessandro Giacomello, Elisa Messina, Roberto Natalini, Giuseppe Pontrelli, Fabrizio Rossi, Robert Smits, Monika Twarogowska
We propose a discrete in continuous mathematical model describing the in vitro growth process of biophsy-derived mammalian cardiac progenitor cells growing as clusters in the form of spheres (Cardiospheres). The approach is hybrid: discrete at cellular scale and continuous at molecular level. In the present model, cells are subject to the self-organizing collective dynamics mechanism and, additionally, they can proliferate and differentiate, also depending on stochastic processes The two latter processes are triggered and regulated by chemical signals present in the environment...
January 23, 2017: Mathematical Medicine and Biology: a Journal of the IMA
https://www.readbyqxmd.com/read/28099883/beta2-adrenergic-signaling-affects-the-phenotype-of-human-cardiac-progenitor-cells-through-emt-modulation
#10
Francesca Pagano, Francesco Angelini, Camilla Siciliano, Julia Tasciotti, Giorgio Mangino, Elena De Falco, Roberto Carnevale, Sebastiano Sciarretta, Giacomo Frati, Isotta Chimenti
Human cardiac progenitor cells (CPCs) offer great promises to cardiac cell therapy for heart failure. Many in vivo studies have shown their therapeutic benefits, paving the way for clinical translation. The 3D model of cardiospheres (CSs) represents a unique niche-like in vitro microenvironment, which includes CPCs and supporting cells. CSs have been shown to form through a process mediated by epithelial-to-mesenchymal transition (EMT). β2-Adrenergic signaling significantly affects stem/progenitor cells activation and mobilization in multiple tissues, and crosstalk between β2-adrenergic signaling and EMT processes has been reported...
January 15, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28052915/intracoronary-cardiac-progenitor-cells-in-single-ventricle-physiology-the-perseus-randomized-phase-2-trial
#11
Shuta Ishigami, Shinichi Ohtsuki, Takahiro Eitoku, Daiki Ousaka, Maiko Kondo, Yoshihiko Kurita, Kenta Hirai, Yosuke Fukushima, Kenji Baba, Takuya Goto, Naohiro Horio, Junko Kobayashi, Yosuke Kuroko, Yasuhiro Kotani, Sadahiko Arai, Tatsuo Iwasaki, Shuhei Sato, Shingo Kasahara, Shunji Sano, Hidemasa Oh
RATIONALE: Patients with single ventricle physiology are at high risk of mortality resulting from ventricular dysfunction. The preliminary results of the phase 1 trial showed cardiosphere-derived cells (CDCs) may be effective against congenital heart failure. OBJECTIVE: To determine if intracoronary delivery of autologous CDCs improves cardiac function in patients with single ventricle physiology. METHODS AND RESULTS: We conducted a phase 2 randomized controlled study to assign 41 patients in a 1:1 ratio who had single ventricle physiology undergoing staged-2 or -3 palliation to receive intracoronary infusion of CDCs 4 to 9 weeks after surgery or staged reconstruction alone (study A)...
January 4, 2017: Circulation Research
https://www.readbyqxmd.com/read/27970213/tct-820-multivessel-intracoronary-infusion-of-allogeneic-cardiosphere-derived-cells-in-dilated-cardiomyopathy-long-term-outcomes-of-the-dilated-cardiomyopathy-intervention-with-allogeneic-myocardially-regenerative-cells-dynamic-trial
#12
Tarun Chakravarty, Raj Makkar, Timothy Henry, Michelle Kittleson, John Friedman, Daniel Berman, Joao Lima, Konstantinos Malliaras, Robert Siegel, Leandro Slipczuk, Jeff Rudy, Eduardo Marban, Janice Pogoda, Linda Marban, Deborah Ascheim
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27923685/a-combined-cellular-and-surgical-ventricular-reconstruction-therapeutic-approach-produces-attenuation-of-remodeling-in-infarcted-rats
#13
Michael J Bonios, Maria Anastasiou-Nana, Despina N Perrea, Konstantinos Malliaras
BACKGROUND: Left ventricular reconstruction (LVR) has been shown to provide transient benefits to the LV structure and function of infarcted hearts; however, long-term results have been disappointing as LVR-induced benefits are typically not sustained. We hypothesized that administration of cardiosphere-derived cells (CDCs), which promote myocardial repair and regeneration, may result in long-term preservation of the beneficial effects of LVR in ischemic cardiomyopathy. METHODS: Wistar Kyoto rats underwent myocardial infarction (MI) and two weeks later were randomized into 3 groups: in Group 1 (n=9), LVR was performed by plication of the infarcted apex and CDCs were injected in the infarct border zone (IBZ); group 2 animals (n=9) underwent LVR and received vehicle solution in the IBZ; and Group 3 animals (n=10) were injected with vehicle solution in the IBZ without undergoing LVR...
December 5, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27844250/differential-response-of-human-cardiac-stem-cells-and-bone-marrow-mesenchymal-stem-cells-to-hypoxia-reoxygenation-injury
#14
Deepthi Sreerengam RajendranNair, Jayakumar Karunakaran, Renuka R Nair
Cardiosphere-derived cells (CDCs) and bone marrow mesenchymal stem cells (MSCs) are popularly used in stem cell therapy for myocardial regeneration. The cell type that survives and maintains stem cell characteristics in the adverse microenvironment following ischemia-reperfusion injury is presumed to be ideal for transplantation. The study was therefore aimed at identifying the cell type with relatively greater resistance to ischemia-reperfusion injury. CDCs were isolated from the right atrial appendage and MSCs from bone marrow of patients who underwent coronary artery bypass graft surgery...
January 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27806113/inhibiting-extracellular-vesicle-release-from-human-cardiosphere-derived-cells-with-lentiviral-knockdown-of-nsmase2-differentially-effects-proliferation-and-apoptosis-in-cardiomyocytes-fibroblasts-and-endothelial-cells-in-vitro
#15
Jennifer K Lang, Rebeccah F Young, Hashmat Ashraf, John M Canty
Numerous studies have shown a beneficial effect of cardiosphere-derived cell (CDC) therapy on regeneration of injured myocardium. Paracrine signaling by CDC secreted exosomes may contribute to improved cardiac function. However, it has not yet been demonstrated by a genetic approach that exosome release contributes to the therapeutic effect of transplanted CDCs. By employing a lentiviral knockdown (KD) strategy against neutral spingomyelinase 2 (nSMase2), a crucial gene in exosome secretion, we have defined the role of physiologically secreted human CDC-derived exosomes on cardiac fibroblast, endothelial cell and primary cardiomyocyte proliferation, cell death, migration and angiogenesis using a series of in vitro coculture assays...
2016: PloS One
https://www.readbyqxmd.com/read/27777191/-effect-of-implantation-of-cardiosphere-derived-cells-combined-with-rat-heart-tissue-derived-extracellular-matrix-on-acute-myocardial-infarction-in-rats
#16
Da-Qing Jiang, Tian-Xiang Gu, Zhao-Fa Xu, Shuang Liu, Xue-Yuan Li
OBJECTIVE: To investigate whether heart tissue-derived extracellular matrix (ECM) promotes the differentiation of cardiosphere-derived cells (CDCs) implanted in rat infracted myocardium to improve the cardiac structure and function. METHODS: Rat CDCs were cultured by cardiac explant methods, and ECM was prepared by decelluariztion method. In a Wistar rat model of acute myocardial infarction established by ligating the left anterior descending branch, IMDM solution, ECM suspension, 10(6) CDCs in IMDM solution, or 10(6) CDCs in ECM suspension were injected into the infracted rat myocardium (6 rats in each group)...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27764217/cardiosphere-derived-cells-facilitate-heart-repair-by-modulating-m1-m2-macrophage-polarization-and-neutrophil-recruitment
#17
Al Shaimaa Hasan, Lan Luo, Chen Yan, Tian-Xia Zhang, Yoshishige Urata, Shinji Goto, Safwat A Mangoura, Mahmoud H Abdel-Raheem, Shouhua Zhang, Tao-Sheng Li
Cardiosphere-derived cells (CDCs), one of the promising stem cell sources for myocardial repair, have been tested in clinical trials and resulted in beneficial effects; however, the relevant mechanisms are not fully understood. In this study, we examined the hypothesis that CDCs favor heart repair by switching the macrophages from a pro-inflammatory phenotype (M1) into a regulatory anti-inflammatory phenotype (M2). Macrophages from mice were cultured with CDCs-conditioned medium or with fibroblasts-conditioned medium as a control...
2016: PloS One
https://www.readbyqxmd.com/read/27738436/heart-derived-stem-cells-in-miniature-swine-with-coronary-microembolization-novel-ischemic-cardiomyopathy-model-to-assess-the-efficacy-of-cell-based-therapy
#18
Gen Suzuki, Rebeccah F Young, Merced M Leiker, Takayuki Suzuki
A major problem in translating stem cell therapeutics is the difficulty of producing stable, long-term severe left ventricular (LV) dysfunction in a large animal model. For that purpose, extensive infarction was created in sinclair miniswine by injecting microspheres (1.5 × 10(6) microspheres, 45 μm diameter) in LAD. At 2 months after embolization, animals (n = 11) were randomized to receive allogeneic cardiosphere-derived cells derived from atrium (CDCs: 20 × 10(6), n = 5) or saline (untreated, n = 6)...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27677883/exosomes-secreted-by-cardiosphere-derived-cells-reduce-scarring-attenuate-adverse-remodelling-and-improve-function-in-acute-and-chronic-porcine-myocardial-infarction
#19
Romain Gallet, James Dawkins, Jackelyn Valle, Eli Simsolo, Geoffrey de Couto, Ryan Middleton, Eleni Tseliou, Daniel Luthringer, Michelle Kreke, Rachel R Smith, Linda Marbán, Bijan Ghaleh, Eduardo Marbán
AIMS: Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and exosomes mimic the benefits of CDCs in rodents. Nevertheless, exosomes have not been studied in a translationally realistic large-animal model. We sought to optimize delivery and assess the efficacy of CDC-secreted exosomes in pig models of acute (AMI) and convalescent myocardial infarction (CMI). METHODS AND RESULTS: In AMI, pigs received human CDC exosomes (or vehicle) by intracoronary (IC) or open-chest intramyocardial (IM) delivery 30 min after reperfusion...
September 27, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27543900/allogeneic-heart-stem-cells-to-achieve-myocardial-regeneration-allstar-trial-rationale-design
#20
Tarun Chakravarty, Raj R Makkar, Deborah Ascheim, Jay H Traverse, Richard Schatz, Anthony DeMaria, Gary S Francis, Thomas J Povsic, Rachel Smith, Joao A Lima, Janice M Pogoda, Linda Marbán, Timothy D Henry
Autologous cardiosphere-derived cells (CDCs) were the first therapeutic modality to demonstrate myocardial regeneration with a decrease in scar size and an increase in viable, functional tissue. Widespread applicability of autologous CDC therapy is limited by the need for patient-specific myocardial biopsy, cell processing and quality control resulting in delays to therapy and inherent logistical and economic constraints. Pre-clinical data had demonstrated equivalent efficiency of allogeneic to autologous CDCs...
August 18, 2016: Cell Transplantation
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