Romain Gallet, Jin-Bo Su, Daphné Corboz, Paul-Matthieu Chiaroni, Alain Bizé, Jianping Dai, Mathieu Panel, Pierre Boucher, Gaëtan Pallot, Juliette Brehat, Lucien Sambin, Guillaume Thery, Nadir Mouri, Aurélien de Pommereau, Pierre Denormandie, Stéphane Germain, Alain Lacampagne, Emmanuel Teiger, Eduardo Marbán, Bijan Ghaleh
Heart failure with preserved ejection fraction (HFpEF) is a major public health concern. Its outcome is poor and, as of today, barely any treatments have been able to decrease its morbidity or mortality. Cardiosphere-derived cells (CDCs) are heart cell products with anti-fibrotic, anti-inflammatory and angiogenic properties. Here, we tested the efficacy of CDCs in improving left ventricular (LV) structure and function in pigs with HFpEF. Fourteen chronically instrumented pigs received continuous angiotensin II infusion for 5 weeks...
July 3, 2023: Basic Research in Cardiology