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Segev DL

Andrada Bogdan, Israel M Barbash, Amit Segev, Paul Fefer, Stefan Nicolae Bogdan, Elad Asher, Noam Fink, Ashraf Hamdan, Dan Spiegelstein, Ehud Raanani, Victor Guetta
AIMS: Albumin is a marker of frailty. Scarce data are available on correlations between frailty-related parameters and outcomes in patients undergoing TAVI. This study sought to evaluate the relation between albumin and mortality in TAVI candidates. METHODS AND RESULTS: A total of 150 patients (mean age 81±6 years) undergoing TAVI were included in the study. Patients with pre-procedural albumin >4 g/dl (>40 g/L) (n=71) were compared to those ≤4 g/dl (≤40 g/L) (n=79)...
October 28, 2015: EuroIntervention
Shmuel Gottlieb, Shimon Kolker, Nir Shlomo, Shlomi Matetzky, Eran Leitersdorf, Amit Segev, Ilan Goldenberg, Dan Tzivoni, Giora Weisz, Mady Moriel
BACKGROUND: STEMI is thought to occur as a result of a vulnerable coronary plaque rupture. Statins possess hypolipidemic and pleotropic effects that stabilize coronary plaque. We sought to determine the association between LDL-C levels, statin use prior to the index event on the type of acute coronary syndrome (ACS) presentation: STEMI vs. non-STEMI/unstable angina. METHODS: Data was drawn from the ACS Israeli Survey (ACSIS), a biennial prospective survey of ACS patients hospitalized in all CCU/Cardiology departments during 2002-2010...
May 1, 2016: International Journal of Cardiology
Grace Younes, Yakir Segev, Julia Begal, Ron Auslender, Yael Goldberg, Amnon Amit, Ofer Lavie
OBJECTIVES: Preoperative hematologic parameters: thrombocytosis, leukocytosis and anemia have been demonstrated to be independent poor prognostic factors in ovarian and endometrial cancers. However, little is known about their relation to uterine serous papillary carcinoma (USPC). We evaluated several preoperative hematologic parameters and their association with clinicopathologic features, disease progression and overall survival in USPC patients. STUDY DESIGN: This was a retrospective cohort study reviewing charts of all patients with a histologic pure USPC at two gynecologic oncology centers from January 2000 through July 2012...
April 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jennifer Ben Oz, Itamar Aroch, Gilad Segev
OBJECTIVE: To describe the clinical and laboratory findings of a dog with gastric perforation, resulting in a markedly increased peritoneal effusion-to-serum potassium ratio. CASE SUMMARY: A 6-year-old mixed breed neutered male dog presented with a right femoral fracture after being hit by car. The fracture was repaired surgically. Four days postoperatively, the dog developed peritoneal effusion, confirmed with ultrasonography. Peritoneal effusion analysis and serum biochemistry, performed concurrently, showed blood-to-effusion glucose difference >1...
January 27, 2016: Journal of Veterinary Emergency and Critical Care
C A Palm, G Segev, L D Cowgill, B E LeRoy, K L Kowalkowski, K Kanakubo, J L Westropp
BACKGROUND: Acute kidney injury (AKI) is associated with high mortality rates in dogs, which may be a consequence of late recognition using traditional diagnostic tests. Neutrophil gelatinase-associated lipocalin (NGAL) is a protein-induced during kidney injury that may identify AKI earlier than traditional tests. OBJECTIVES/HYPOTHESIS: To evaluate urinary NGAL (uNGAL) and uNGAL-to-urinary creatinine ratio (UNCR) as early markers of kidney injury and recovery in an AKI model in dogs...
January 2016: Journal of Veterinary Internal Medicine
G Segev, S Daminet, E Meyer, J De Loor, A Cohen, I Aroch, Y Bruchim
Heatstroke is often associated with acute kidney injury (AKI). The objectives of this study were to characterize the kidney damage occurring in canine heatstroke using routine and novel biomarkers and to assess their diagnostic and prognostic performance. Thirty dogs with naturally occurring heatstroke were enrolled prospectively. Blood and urine specimens were collected at presentation, at 4 h post-presentation and every 12 h until discharge or death. The glomerular filtration rate (GFR) and electrolyte fractional excretion (FE) at 4 h post-presentation were also calculated, based on urinary clearances...
November 2015: Veterinary Journal
S Klainbart, E Kelmer, B Vidmayer, T Bdolah-Abram, G Segev, I Aroch
BACKGROUND: Acute limb paralysis because of arterial thromboembolism (ATE) occurs in cats and less commonly in dogs. ATE is diagnosed based on physical examination findings and, occasionally, advanced imaging. HYPOTHESIS/OBJECTIVES: Peripheral, affected limb venous glucose concentration is decreased in ATE, whereas its systemic concentration is within or above reference interval. ANIMALS: Client-owned cats and dogs were divided into 3 respective groups: acute limb paralysis because of ATE (22 cats and 9 dogs); acute limb paralysis secondary to orthopedic or neurologic conditions (nonambulatory controls; 10 cats and 11 dogs); ambulatory animals presented because of various diseases (ambulatory controls; 10 cats and 9 dogs)...
September 2014: Journal of Veterinary Internal Medicine
Assi Milwidsky, Shaye Kivity, Eran Kopel, Robert Klempfner, Anat Berkovitch, Shlomo Segev, Yechezkel Sidi, Ilan Goldenberg, Elad Maor
BACKGROUND: High-density lipoprotein cholesterol (HDL-C) is a strong inverse predictor of cardiovascular events. The aim of the current study was to evaluate the correlation between changes in HDL-C and subsequent cardiovascular events. METHODS: Study population comprised 13,037 subjects free of cardiovascular disease with a mean follow up of 6 ± 3 years. Low HDL-C was defined as < 40 mg/dl for men and <50mg/dl for women. Participants were divided into three groups based on HDL-C levels at the first and second baseline visits: persistently-low HDL-C (LL); persistently-high HDL-C (HH); and those with high HDL-C in a one visit only: intermittently high HDL-C (LH/HL)...
May 1, 2014: International Journal of Cardiology
David Pereg, Avishay Elis, Yoram Neuman, Morris Mosseri, Avi Leader, David Segev, Martine Granek-Catarivas, Michael Lishner, Doron Hermoni
BACKGROUND: Guidelines recommend low-density lipoprotein-cholesterol (LDL-C) target of <70 mg/dL in patients with coronary disease. However, this goal is not achieved in many patients. OBJECTIVES: We compared LDL-C control in patients with coronary disease treated by a primary care physician or with the addition of a cardiologist. METHODS: Included were patients with coronary disease who had full lipid profile. Primary end points included the percentage of patients who achieved the LDL-C goals of <100 mg/dL and <70 mg/dL...
November 2013: Journal of Clinical Lipidology
Shaye Kivity, Eran Kopel, Shmuel Steinlauf, Shlomo Segev, Yechezkel Sidi, David Olchovsky
OBJECTIVE: Previous studies have demonstrated an association between increased serum uric acid (SUA) levels and incident diabetes. Most clinical and epidemiological investigations, however, focused solely on male populations or did not analyze men and women separately. We assessed the association between SUA levels and diabetes incidence in a large cohort of apparently healthy men and women. METHODS: Data were retrospectively gathered from 9140 adults who participated in annual medical screening visits during 2000-2009...
September 2013: Journal of Women's Health
Shaye Kivity, Eran Kopel, Elad Maor, Fadi Abu-Bachar, Shlomo Segev, Yechezkel Sidi, David Olchovsky
Studies in different populations with high risk for cardiovascular disease (CVD) have shown an association between serum uric acid (SUA) and CVD. However, only a few studies have demonstrated such an association in healthy populations. The aim of this study was to investigate the association between SUA and CVD in a cohort of men and women without diabetes or CVD. A retrospective study was conducted, with a mean 4.8-year follow-up. The outcome was the occurrence of a cardiovascular event, defined as the diagnosis of ischemic heart disease, acute coronary syndrome, acute myocardial infarction, or ischemic stroke...
April 15, 2013: American Journal of Cardiology
David Pereg, Yoram Neuman, Avishay Elis, Sa'ar Minha, Morris Mosseri, David Segev, Michael Lishner, Doron Hermoni
Peripheral arterial disease (PAD) is a strong risk factor for cardiovascular morbidity and mortality. Therefore, target low-density lipoprotein (LDL) cholesterol level in patients with PAD is ≤70 mg/dl, similar to patients with coronary artery disease (CAD). However, despite their high cardiovascular risk, patients with PAD less frequently achieve LDL cholesterol goals compared to patients with CAD. We aimed to compare LDL cholesterol control in patients after first coronary or peripheral vascular intervention...
November 1, 2012: American Journal of Cardiology
Kivity Shaye, Tirosh Amir, Segev Shlomo, Sidi Yechezkel
BACKGROUND: Diabetes mellitus and impaired glucose metabolism are associated with increased risk for cardiovascular disease (CVD). However, it is still not clear whether glucose levels can predict CVD risk among patients without diabetes. The primary aim of this study is to assess whether normoglycemic fasting plasma glucose (FPG) is associated with increased risk of CVD outcomes in healthy patients. METHODS: We obtained blood measurements, data from physical examination, and medical and lifestyle information from 10,913 men and women who were evaluated in the Institute for Preventive Medicine of Sheba Medical Center...
July 2012: American Heart Journal
G Segev, L D Cowgill, S Jessen, A Berkowitz, C F Mohr, I Aroch
BACKGROUND: Renal amyloidosis (RA) is a progressive and fatal renal disease. HYPOTHESIS: Clinical and pathologic manifestations of RA differ between Chinese Shar-Pei (CSPs) and non-Shar-Pei (NSPs) dogs. ANIMALS: 91 client-owned dogs. METHODS: Retrospective review of medical records of dogs with a histological diagnosis of RA. Clinical and clinicopathologic data, hospitalization, complications, and outcome were compared between CSPs and NSPs...
March 2012: Journal of Veterinary Internal Medicine
Bonnie E Lonze, Nabil N Dagher, Minghao Liu, Lauren M Kucirka, Christopher E Simpkins, Jayme E Locke, Niraj M Desai, Andrew M Cameron, Robert A Montgomery, Dorry L Segev, Andrew L Singer
HYPOTHESIS: The use of kidneys from deceased donors considered at increased infectious risk represents a strategy to increase the donor pool. DESIGN: Single-institution longitudinal observational study. SETTING: Tertiary care center. PATIENTS: Fifty patients who gave special informed consent to receive Centers for Disease Control and Prevention high-risk (CDCHR) donor kidneys were followed up by serial testing for viral transmission after transplantation...
November 2011: Archives of Surgery
Anurag Maheshwari, Rebecca Rankin, Dorry L Segev, Paul J Thuluvath
BACKGROUND: The clinical characteristics and outcomes of patients with glycogen storage disease (GSD) who undergo liver transplantation (LT) have not been well defined. In this study, our objective was to determine the outcome of LT in patients with GSD and compare it with a comparable group of patients without GSD (matched controls). METHODS: UNOS data from 1986 to 2007 were used for this study. For each GSD patient (n = 95; men 62%) who was transplanted, three patients (n = 285, men 60%) without GSD (case controls) matched for age ± five yr, year of transplantation and donor risk index (DRI) ± 0...
May 2012: Clinical Transplantation
Gillian Dank, Kenneth M Rassnick, Orna Kristal, Carlos O Rodriguez, Craig A Clifford, Rebecca Ward, Courtney L Mallett, Tracy Gieger, Gilad Segev
OBJECTIVE-To determine outcome of dogs with presumed primary hepatic lymphoma treated with various multiagent, doxorubicin-based chemotherapeutic protocols and identify factors associated with prognosis. DESIGN-Retrospective case series. ANIMALS-18 dogs with presumed primary hepatic lymphoma. PROCEDURES-Medical records were reviewed for information on signalment, treatment, and outcome. RESULTS-8 dogs had a complete remission (CR), with a median remission duration of 120 days. Dogs with leukocytosis, neutrophilia, hypoalbuminemia, hyperbilirubinemia, or a combination of hypoalbuminemia and hyperbilirubinemia were less likely to achieve a CR...
October 1, 2011: Journal of the American Veterinary Medical Association
Avishay Elis, David Pereg, Paul Froom, Michael Lishner, David Segev, Doron Hermoni
BACKGROUND: A low level of high-density lipoprotein cholesterol (HDL-C) is a strong predictor for cardiovascular disease morbidity and mortality at all low-density lipoprotein cholesterol (LDL-C) concentrations. HYPOTHESIS: We evaluated this association in routine clinical practice among statin-treated coronary heart disease patients who achieved LDL-C target levels. This association also exists in routine clinical practice. METHODS: A retrospective dynamic cohort included all male coronary heart disease patients of the Sharon-Shomron district, Clalit Health Services, Israel, with LDL-C levels < 100 mg/dL and who were receiving statins (≥ 6 purchases/y) from January 1998 to June 2008...
September 2011: Clinical Cardiology
D L Segev, J L Veale, J C Berger, J M Hiller, R L Hanto, D B Leeser, S R Geffner, S Shenoy, W I Bry, S Katznelson, M L Melcher, M A Rees, E N S Samara, A K Israni, M Cooper, R J Montgomery, L Malinzak, J Whiting, D Baran, J I Tchervenkov, J P Roberts, J Rogers, D A Axelrod, C E Simpkins, R A Montgomery
Optimizing the possibilities for kidney-paired donation (KPD) requires the participation of donor-recipient pairs from wide geographic regions. Initially it was envisaged that donors would travel to the recipient center; however, to minimize barriers to participation and simplify logistics, recent trends have involved transporting the kidneys rather than the donors. The goal of this study was to review outcomes of this practice. KPD programs throughout the United States were directly queried about all transplants involving live donor kidney transport...
February 2011: American Journal of Transplantation
Paul Fefer, Hanoch Hod, Jacob Ilany, Michael Shechter, Amit Segev, Ilia Novikov, Victor Guetta, Shlomi Matetzky
Diabetes and impaired fasting glucose (FG) were associated with worse outcomes in patients with acute myocardial infarction (MI). Because the underlying mechanism is not entirely clear, 376 consecutive patients with ST-elevation MI who underwent primary percutaneous coronary intervention (PPCI) were investigated. Patients were divided into 3 groups based on FG < or =100, FG of 101 to 125, and FG >125 mg/dl or previously diagnosed diabetes mellitus (DM) and studied for electrocardiographic signs of myocardial reperfusion (both spontaneous and after PPCI) and clinical outcomes...
December 1, 2008: American Journal of Cardiology
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