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Weissman antibiotic

Matthew P Kronman, Assaf P Oron, Rachael K Ross, Adam L Hersh, Jason G Newland, Adam Goldin, Shawn J Rangel, Scott J Weissman, Danielle M Zerr, Jeffrey S Gerber
BACKGROUND AND OBJECTIVES: Appendicitis guidelines recommend either narrower- or extended-spectrum antibiotics for treatment of complicated appendicitis. The goal of this study was to compare the effectiveness of extended-spectrum versus narrower-spectrum antibiotics for children with appendicitis. METHODS: We performed a retrospective cohort study of children aged 3 to 18 years discharged between 2011 and 2013 from 23 freestanding children's hospitals with an appendicitis diagnosis and appendectomy performed...
July 2016: Pediatrics
Jason M Peters, Alexandre Colavin, Handuo Shi, Tomasz L Czarny, Matthew H Larson, Spencer Wong, John S Hawkins, Candy H S Lu, Byoung-Mo Koo, Elizabeth Marta, Anthony L Shiver, Evan H Whitehead, Jonathan S Weissman, Eric D Brown, Lei S Qi, Kerwyn Casey Huang, Carol A Gross
Essential gene functions underpin the core reactions required for cell viability, but their contributions and relationships are poorly studied in vivo. Using CRISPR interference, we created knockdowns of every essential gene in Bacillus subtilis and probed their phenotypes. Our high-confidence essential gene network, established using chemical genomics, showed extensive interconnections among distantly related processes and identified modes of action for uncharacterized antibiotics. Importantly, mild knockdown of essential gene functions significantly reduced stationary-phase survival without affecting maximal growth rate, suggesting that essential protein levels are set to maximize outgrowth from stationary phase...
June 2, 2016: Cell
Monika Jelic, Amanda L Adler, Arianna Miles-Jay, Scott J Weissman, Matthew P Kronman, Danielle M Zerr
We used the Pediatric Health Information System database to assess the use of antibiotics reserved for the treatment of resistant Gram-negative infections in children from 2004 to 2014. Overall, use of these agents increased in children from 2004 to 2007 and subsequently decreased. Infect Control Hosp Epidemiol 2016:37:967-970.
August 2016: Infection Control and Hospital Epidemiology
Danielle M Zerr, Arianna Miles-Jay, Matthew P Kronman, Chuan Zhou, Amanda L Adler, Wren Haaland, Scott J Weissman, Alexis Elward, Jason G Newland, Theoklis Zaoutis, Xuan Qin
The objective of this study was to determine whether antibiotic exposure is associated with extended-spectrum-beta-lactamase- or AmpC-producing Escherichia coli or Klebsiella pneumoniae infections in children. We collected extended-spectrum-beta-lactamase- or AmpC-producing E. coli or K. pneumoniae isolates and same-species susceptible controls from normally sterile sites of patients aged ≤21 years, along with associated clinical data, at four free-standing pediatric centers. After controlling for potential confounders, the relative risk of having an extended-spectrum-beta-lactamase-producing isolate rather than a susceptible isolate was 2...
July 2016: Antimicrobial Agents and Chemotherapy
James R Johnson, Paul Thuras, Brian D Johnston, Scott J Weissman, Ajit P Limaye, Kim Riddell, Delia Scholes, Veronika Tchesnokova, Evgeni Sokurenko
BACKGROUND: The H30 subclone within Escherichia coli sequence type 131 (ST131-H30) has emerged rapidly to become the leading antibiotic-resistant E. coli strain. Hypervirulence, multidrug resistance, and opportunism have been proposed as explanations for its epidemic success. METHODS: We assessed 1133 consecutive unique E. coli clinical isolates from 5 medical centers (2010-2011) for H30 genotype, which we compared with epidemiological and clinical data extracted from medical records by blinded reviewers...
June 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Harish Bhandari, Rina Agrawal, Ariel Weissman, Gon Shoham, Milton Leong, Zeev Shoham
OBJECTIVE: The objective of this study was to identify clinical practices worldwide, which would help in recognizing women at risk of excessive bleeding or of developing pelvic infection following trans-vaginal ovum pick-up (TV-OPU), measures taken to minimize risks and their management. METHOD: A prospective, web-based questionnaire with distinct questions related to the practice of TV-OPU. RESULTS: A total of 155 units from 55 countries performing 97,200 IVF cycles annually responded to this web-based survey...
December 2015: Journal of Obstetrics and Gynaecology of India
Scott C Olson, Sherilyn Smith, Scott J Weissman, Matthew P Kronman
BACKGROUND: Although long treatment courses of outpatient antimicrobials are often used in pediatric patients, few data exist regarding the frequency of adverse events (AEs) associated with these medications. METHODS: We performed a retrospective cohort study of all patients seen in the Infectious Diseases clinic at a tertiary referral children's hospital from August 1, 2009 to August 1, 2011. We included patients who received ≥14 days of oral or intravenous antibiotic, antiviral, or antifungal medications...
June 2015: Journal of the Pediatric Infectious Diseases Society
Scott J Weissman, Nellie I Hansen, Kristen Zaterka-Baxter, Rosemary D Higgins, Barbara J Stoll
BACKGROUND: Escherichia coli associated with early-onset sepsis (EOS) have historically been antibiotic-susceptible and K1-encapsulated. In the era of emerging antibiotic resistance, however, the clonal makeup of E coli associated with EOS has not been well characterized. METHODS: Escherichia coli isolates were collected from 28 cases of EOS and early-onset meningitis (EOM) from April 2008 through December 2009, during a parent study conducted at National Institute of Child Health and Human Development Neonatal Research Network centers from February 2006 through December 2009...
September 2016: Journal of the Pediatric Infectious Diseases Society
Minghong Li, Veronica Holmes, Houping Ni, Jenine K Sanzari, Ana L Romero-Weaver, Liyong Lin, Alejandro Carabe-Fernandez, Eric S Diffenderfer, Ann R Kennedy, Drew Weissman
A major risk for astronauts during prolonged space flight is infection as a result of the combined effects of microgravity, situational and confinement stress, alterations in food intake, altered circadian rhythm, and radiation that can significantly impair the immune system and the body's defense systems. We previously reported a massive increase in morbidity with a decrease in the ability to control a bacterial challenge when mice were maintained under hindlimb suspension (HS) conditions and exposed to solar particle event (SPE)-like radiation...
2015: PloS One
Noa Eliakim-Raz, Adi Lador, Yaara Leibovici-Weissman, Michal Elbaz, Mical Paul, Leonard Leibovici
OBJECTIVES: Chloramphenicol is an old broad-spectrum antibiotic. We assessed its efficacy and safety. METHODS: This was a systematic review and meta-analysis. Electronic databases were searched to identify randomized controlled trials (RCTs) that assessed patients, of any age, with systemic bacterial infections that can cause sepsis and compared chloramphenicol alone versus other antibiotics. No restrictions on the date of publication, language or publication status were applied...
April 2015: Journal of Antimicrobial Chemotherapy
Adam L Hersh, Stephen A De Lurgio, Cary Thurm, Brian R Lee, Scott J Weissman, Joshua D Courter, Thomas V Brogan, Samir S Shah, Matthew P Kronman, Jeffrey S Gerber, Jason G Newland
BACKGROUND AND OBJECTIVE: Single-center evaluations of pediatric antimicrobial stewardship programs (ASPs) suggest that ASPs are effective in reducing and improving antibiotic prescribing, but studies are limited. Our objective was to compare antibiotic prescribing rates in a group of pediatric hospitals with formalized ASPs (ASP+) to a group of concurrent control hospitals without formalized stewardship programs (ASP-). METHODS: We evaluated the impact of ASPs on antibiotic prescribing over time measured by days of therapy/1000 patient-days in a group of 31 freestanding children's hospitals (9 ASP+, 22 ASP-)...
January 2015: Pediatrics
Krishna Kannan, Pinal Kanabar, David Schryer, Tanja Florin, Eugene Oh, Neil Bahroos, Tanel Tenson, Jonathan S Weissman, Alexander S Mankin
Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially affect synthesis of individual proteins. To understand the general mechanism of macrolide action, we used genome-wide ribosome profiling and analyzed the redistribution of ribosomes translating highly expressed genes in bacterial cells treated with high concentrations of macrolide antibiotics...
November 11, 2014: Proceedings of the National Academy of Sciences of the United States of America
Jiraporn Sri-On, Yuchiao Chang, David P Curley, Carlos A Camargo, Joel S Weissman, Sara J Singer, Shan W Liu
BACKGROUND: Hospital crowding and emergency department (ED) boarding are large and growing problems. To date, there has been a paucity of information regarding the quality of care received by patients boarding in the ED compared with the care received by patients on an inpatient unit. We compared the rate of delays and adverse events at the event level that occur while boarding in the ED vs while on an inpatient unit. METHODS: This study was a secondary analysis of data from medical record review and administrative databases at 2 urban academic teaching hospitals from August 1, 2004, through January 31, 2005...
September 2014: American Journal of Emergency Medicine
Ya'ara Leibovici-Weissman, Ami Neuberger, Roni Bitterman, David Sinclair, Mohammed Abdus Salam, Mical Paul
BACKGROUND: Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which if severe can cause rapid dehydration and death. Effective management requires early diagnosis and rehydration using oral rehydration salts or intravenous fluids. In this review, we evaluate the additional benefits of treating cholera with antimicrobial drugs. OBJECTIVES: To quantify the benefit of antimicrobial treatment for patients with cholera, and determine whether there are differences between classes of antimicrobials or dosing schedules...
2014: Cochrane Database of Systematic Reviews
Anna C Sick, Sarah Tschudin-Sutter, Alison E Turnbull, Scott J Weissman, Pranita D Tamma
BACKGROUND: Empirical combination antibiotic regimens consisting of a β-lactam and an aminoglycoside are frequently employed in the pediatric population. Data to demonstrate the comparative benefit of empirical β-lactam combination therapy relative to monotherapy for culture-proven Gram-negative bacteremia are lacking in the pediatric population. METHODS: We conducted a retrospective cohort study of children treated for Gram-negative bacteremia at The Johns Hopkins Hospital from 2004 through 2012...
May 2014: Pediatrics
Malaika L Little, Xuan Qin, Danielle M Zerr, Scott J Weissman
Klebsiella pneumoniae causes a range of clinical disease in paediatric patients and is of increasing concern due to growing antibiotic resistance, yet little is known about the relative distribution of commensal and pathogens throughout the population structure of K. pneumoniae. We conducted a prospective, observational study of 92 isolates from Seattle Children's Hospital, including 49 disease isolates from blood and urine (13 and 36 isolates, respectively) and 43 colonization isolates from stool. Susceptibility to 20 antimicrobials was evaluated using disc diffusion, VITEK 2 and Etest...
April 2014: Journal of Medical Microbiology
Sharon Weissman, R David Parker, Wajid Siddiqui, Shana Dykema, Joseph Horvath
INTRODUCTION: Infectious vertebral osteomyelitis (VO) is a significant source of morbidity that can lead to chronic sequelae. The objectives of this study were to describe the clinical presentations and assess the outcomes of VO. METHODS: A retrospective review of cases of VO admitted to an inpatient service between 1 January 2000 and 31 March 2012 was carried out. Cases had evidence of VO by clinical syndrome, imaging, histopathology, and/or microbiology. Outcomes assessed were implantation of prosthetic material for stabilization, hospital readmission for management of VO, repeat surgical intervention, and additional or prolonged courses of antibiotics...
March 2014: Scandinavian Journal of Infectious Diseases
Hadar Israeli Ben-Noon, Nimrod Farber, Oren Weissman, Ariel Tessone, Demetris Stavrou, Moshe Shabtai, Yasmin Maor, Joseph Haik, Eyal Winkler
In recent years the acellular dermal matrix (ADM) has gained popularity in prosthetic breast reconstruction. These procedures involve placement of a closed suction drain in the reconstructed breast. Although it is now widely accepted that ADM has an overall positive effect on the outcome of breast reconstruction, data regarding its effect on postoperative drain secretions is lacking. This study was designed to quantitatively evaluate the influence of ADM on postoperative drain secretions in the setting of immediate prosthetic breast reconstruction (IPBR)...
September 2013: Journal of Plastic Surgery and Hand Surgery
Oren Weissman, Gabriel Hundeshagen, Moti Harats, Nimrod Farber, Eran Millet, Eyal Winkler, Isaac Zilinsky, Josef Haik
Second degree facial burns usually impart high wound site pain levels and patient discomfort due to the abundance of facial sensory innervation, as well as the development of edema and inflammation that accompany wound healing. Frequent changing of adherent dressings causes additional procedural pain and may prolong healing due to recurring damage to the wound bed. We applied face masks, made on-site from a drug free polymeric membrane dressing, to 8 patients with superficial and deep 2nd degree facial burns...
September 2013: Burns: Journal of the International Society for Burn Injuries
Scott J Weissman, Amanda Adler, Xuan Qin, Danielle M Zerr
Resistance to extended-spectrum β-lactams is increasing worldwide among Escherichia coli and has been linked to a small number of emergent clones (e.g. ST38, ST131 and ST405) recovered from extraintestinal infections in community and hospital settings. There are, however, limited data about the relative contributions of bacterial strains, plasmids and β-lactamase genes to extended-spectrum β-lactam resistance in paediatric infections. We performed an extensive molecular analysis of phylogenetic, virulence and antibiotic resistance-related properties of 49 previously reported serial E...
May 2013: International Journal of Antimicrobial Agents
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