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Weissman antibiotic

Nicole M Poole, Matthew P Kronman, Lori Rutman, Scott J Weissman, Russell T Migita, Derya Caglar, Danielle M Zerr
OBJECTIVES: Children with urinary tract infection (UTI) are often diagnosed in emergency and urgent care settings and increasingly are unnecessarily treated with broad-spectrum antibiotics. This study evaluated the effect of a quality improvement intervention on empiric antibiotic prescribing for the treatment of uncomplicated UTI in children. METHODS: A local clinical pathway for uncomplicated UTI, introduced in June 2010, recommended empiric treatment with cephalexin, a narrow-spectrum (first-generation) cephalosporin antibiotic...
January 2, 2018: Pediatric Emergency Care
Christophe Jacob, Kira J Weissman
Streptomyces are the principle source of antibiotics in clinical use, but what the bacteria use these molecules for remains largely a mystery. In this issue of Cell Chemical Biology, Hoefler et al. (2017) demonstrate a direct link between biosynthesis of the polyketide linearmycins and extracellular membrane vesicles.
October 19, 2017: Cell Chemical Biology
Joshua M Liao, Marilyn S Schapira, Amol S Navathe, Nandita Mitra, Arlene Weissman, David A Asch
No abstract text is available yet for this article.
August 1, 2017: Annals of Internal Medicine
Nikhila Raol, Meesha Sharma, Emily F Boss, Wei Jiang, John W Scott, Peter Learn, Joel S Weissman
Objective To compare number of infections and health care utilization in children insured by TRICARE with recurrent acute otitis media (RAOM) managed surgically with tympanostomy tube (TT) placement compared with those managed medically. Study Design Retrospective matched cohort study. Setting TRICARE claims database from 2006 to 2010. Subjects and Methods We matched TRICARE beneficiaries ≤5 years of age diagnosed with RAOM who underwent TT placement with those managed medically using 1:1 coarsened-exact matching on age, sex, race, sponsor rank, and region...
November 2017: Otolaryngology—Head and Neck Surgery
Veronika Tchesnokova, Hovhannes Avagyan, Elena Rechkina, Diana Chan, Mariya Muradova, Helen Ghirmai Haile, Matthew Radey, Scott Weissman, Kim Riddell, Delia Scholes, James R Johnson, Evgeni V Sokurenko
Despite the known clonal distribution of antibiotic resistance in many bacteria, empiric (pre-culture) antibiotic selection still relies heavily on species-level cumulative antibiograms, resulting in overuse of broad-spectrum agents and excessive antibiotic/pathogen mismatch. Urinary tract infections (UTIs), which account for a large share of antibiotic use, are caused predominantly by Escherichia coli, a highly clonal pathogen. In an observational clinical cohort study of urgent care patients with suspected UTI, we assessed the potential for E...
2017: PloS One
Sibani Das, Amanda L Adler, Arianna Miles-Jay, Matthew P Kronman, Xuan Qin, Scott J Weissman, C A Burnham, Alexis Elward, Jason G Newland, Rangaraj Selvarangan, Kaede V Sullivan, Theoklis Zaoutis, Danielle M Zerr
The objective of this study was to assess the association between previous antibiotic use, particularly long-term prophylaxis, and the occurrence of subsequent resistant infections in children with index infections due to extended-spectrum-cephalosporin-resistant Enterobacteriaceae We also investigated the concordance of the index and subsequent isolates. Extended-spectrum-cephalosporin-resistant Escherichia coli and Klebsiella spp. isolated from normally sterile sites of patients aged <22 years were collected along with associated clinical data from four freestanding pediatric centers...
May 2017: Antimicrobial Agents and Chemotherapy
Matthew P Kronman, Assaf P Oron, Rachael K Ross, Adam L Hersh, Jason G Newland, Adam Goldin, Shawn J Rangel, Scott J Weissman, Danielle M Zerr, Jeffrey S Gerber
BACKGROUND AND OBJECTIVES: Appendicitis guidelines recommend either narrower- or extended-spectrum antibiotics for treatment of complicated appendicitis. The goal of this study was to compare the effectiveness of extended-spectrum versus narrower-spectrum antibiotics for children with appendicitis. METHODS: We performed a retrospective cohort study of children aged 3 to 18 years discharged between 2011 and 2013 from 23 freestanding children's hospitals with an appendicitis diagnosis and appendectomy performed...
July 2016: Pediatrics
Jason M Peters, Alexandre Colavin, Handuo Shi, Tomasz L Czarny, Matthew H Larson, Spencer Wong, John S Hawkins, Candy H S Lu, Byoung-Mo Koo, Elizabeth Marta, Anthony L Shiver, Evan H Whitehead, Jonathan S Weissman, Eric D Brown, Lei S Qi, Kerwyn Casey Huang, Carol A Gross
Essential gene functions underpin the core reactions required for cell viability, but their contributions and relationships are poorly studied in vivo. Using CRISPR interference, we created knockdowns of every essential gene in Bacillus subtilis and probed their phenotypes. Our high-confidence essential gene network, established using chemical genomics, showed extensive interconnections among distantly related processes and identified modes of action for uncharacterized antibiotics. Importantly, mild knockdown of essential gene functions significantly reduced stationary-phase survival without affecting maximal growth rate, suggesting that essential protein levels are set to maximize outgrowth from stationary phase...
June 2, 2016: Cell
Monika Jelic, Amanda L Adler, Arianna Miles-Jay, Scott J Weissman, Matthew P Kronman, Danielle M Zerr
We used the Pediatric Health Information System database to assess the use of antibiotics reserved for the treatment of resistant Gram-negative infections in children from 2004 to 2014. Overall, use of these agents increased in children from 2004 to 2007 and subsequently decreased. Infect Control Hosp Epidemiol 2016:37:967-970.
August 2016: Infection Control and Hospital Epidemiology
Danielle M Zerr, Arianna Miles-Jay, Matthew P Kronman, Chuan Zhou, Amanda L Adler, Wren Haaland, Scott J Weissman, Alexis Elward, Jason G Newland, Theoklis Zaoutis, Xuan Qin
The objective of this study was to determine whether antibiotic exposure is associated with extended-spectrum-beta-lactamase- or AmpC-producing Escherichia coli or Klebsiella pneumoniae infections in children. We collected extended-spectrum-beta-lactamase- or AmpC-producing E. coli or K. pneumoniae isolates and same-species susceptible controls from normally sterile sites of patients aged ≤21 years, along with associated clinical data, at four free-standing pediatric centers. After controlling for potential confounders, the relative risk of having an extended-spectrum-beta-lactamase-producing isolate rather than a susceptible isolate was 2...
July 2016: Antimicrobial Agents and Chemotherapy
James R Johnson, Paul Thuras, Brian D Johnston, Scott J Weissman, Ajit P Limaye, Kim Riddell, Delia Scholes, Veronika Tchesnokova, Evgeni Sokurenko
BACKGROUND: The H30 subclone within Escherichia coli sequence type 131 (ST131-H30) has emerged rapidly to become the leading antibiotic-resistant E. coli strain. Hypervirulence, multidrug resistance, and opportunism have been proposed as explanations for its epidemic success. METHODS: We assessed 1133 consecutive unique E. coli clinical isolates from 5 medical centers (2010-2011) for H30 genotype, which we compared with epidemiological and clinical data extracted from medical records by blinded reviewers...
June 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Harish Bhandari, Rina Agrawal, Ariel Weissman, Gon Shoham, Milton Leong, Zeev Shoham
OBJECTIVE: The objective of this study was to identify clinical practices worldwide, which would help in recognizing women at risk of excessive bleeding or of developing pelvic infection following trans-vaginal ovum pick-up (TV-OPU), measures taken to minimize risks and their management. METHOD: A prospective, web-based questionnaire with distinct questions related to the practice of TV-OPU. RESULTS: A total of 155 units from 55 countries performing 97,200 IVF cycles annually responded to this web-based survey...
December 2015: Journal of Obstetrics and Gynaecology of India
Scott C Olson, Sherilyn Smith, Scott J Weissman, Matthew P Kronman
BACKGROUND: Although long treatment courses of outpatient antimicrobials are often used in pediatric patients, few data exist regarding the frequency of adverse events (AEs) associated with these medications. METHODS: We performed a retrospective cohort study of all patients seen in the Infectious Diseases clinic at a tertiary referral children's hospital from August 1, 2009 to August 1, 2011. We included patients who received ≥14 days of oral or intravenous antibiotic, antiviral, or antifungal medications...
June 2015: Journal of the Pediatric Infectious Diseases Society
Scott J Weissman, Nellie I Hansen, Kristen Zaterka-Baxter, Rosemary D Higgins, Barbara J Stoll
BACKGROUND: Escherichia coli associated with early-onset sepsis (EOS) have historically been antibiotic-susceptible and K1-encapsulated. In the era of emerging antibiotic resistance, however, the clonal makeup of E coli associated with EOS has not been well characterized. METHODS: Escherichia coli isolates were collected from 28 cases of EOS and early-onset meningitis (EOM) from April 2008 through December 2009, during a parent study conducted at National Institute of Child Health and Human Development Neonatal Research Network centers from February 2006 through December 2009...
September 2016: Journal of the Pediatric Infectious Diseases Society
Minghong Li, Veronica Holmes, Houping Ni, Jenine K Sanzari, Ana L Romero-Weaver, Liyong Lin, Alejandro Carabe-Fernandez, Eric S Diffenderfer, Ann R Kennedy, Drew Weissman
A major risk for astronauts during prolonged space flight is infection as a result of the combined effects of microgravity, situational and confinement stress, alterations in food intake, altered circadian rhythm, and radiation that can significantly impair the immune system and the body's defense systems. We previously reported a massive increase in morbidity with a decrease in the ability to control a bacterial challenge when mice were maintained under hindlimb suspension (HS) conditions and exposed to solar particle event (SPE)-like radiation...
2015: PloS One
Noa Eliakim-Raz, Adi Lador, Yaara Leibovici-Weissman, Michal Elbaz, Mical Paul, Leonard Leibovici
OBJECTIVES: Chloramphenicol is an old broad-spectrum antibiotic. We assessed its efficacy and safety. METHODS: This was a systematic review and meta-analysis. Electronic databases were searched to identify randomized controlled trials (RCTs) that assessed patients, of any age, with systemic bacterial infections that can cause sepsis and compared chloramphenicol alone versus other antibiotics. No restrictions on the date of publication, language or publication status were applied...
April 2015: Journal of Antimicrobial Chemotherapy
Adam L Hersh, Stephen A De Lurgio, Cary Thurm, Brian R Lee, Scott J Weissman, Joshua D Courter, Thomas V Brogan, Samir S Shah, Matthew P Kronman, Jeffrey S Gerber, Jason G Newland
BACKGROUND AND OBJECTIVE: Single-center evaluations of pediatric antimicrobial stewardship programs (ASPs) suggest that ASPs are effective in reducing and improving antibiotic prescribing, but studies are limited. Our objective was to compare antibiotic prescribing rates in a group of pediatric hospitals with formalized ASPs (ASP+) to a group of concurrent control hospitals without formalized stewardship programs (ASP-). METHODS: We evaluated the impact of ASPs on antibiotic prescribing over time measured by days of therapy/1000 patient-days in a group of 31 freestanding children's hospitals (9 ASP+, 22 ASP-)...
January 2015: Pediatrics
Krishna Kannan, Pinal Kanabar, David Schryer, Tanja Florin, Eugene Oh, Neil Bahroos, Tanel Tenson, Jonathan S Weissman, Alexander S Mankin
Macrolides are clinically important antibiotics thought to inhibit bacterial growth by impeding the passage of newly synthesized polypeptides through the nascent peptide exit tunnel of the bacterial ribosome. Recent data challenged this view by showing that macrolide antibiotics can differentially affect synthesis of individual proteins. To understand the general mechanism of macrolide action, we used genome-wide ribosome profiling and analyzed the redistribution of ribosomes translating highly expressed genes in bacterial cells treated with high concentrations of macrolide antibiotics...
November 11, 2014: Proceedings of the National Academy of Sciences of the United States of America
Jiraporn Sri-On, Yuchiao Chang, David P Curley, Carlos A Camargo, Joel S Weissman, Sara J Singer, Shan W Liu
BACKGROUND: Hospital crowding and emergency department (ED) boarding are large and growing problems. To date, there has been a paucity of information regarding the quality of care received by patients boarding in the ED compared with the care received by patients on an inpatient unit. We compared the rate of delays and adverse events at the event level that occur while boarding in the ED vs while on an inpatient unit. METHODS: This study was a secondary analysis of data from medical record review and administrative databases at 2 urban academic teaching hospitals from August 1, 2004, through January 31, 2005...
September 2014: American Journal of Emergency Medicine
Ya'ara Leibovici-Weissman, Ami Neuberger, Roni Bitterman, David Sinclair, Mohammed Abdus Salam, Mical Paul
BACKGROUND: Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which if severe can cause rapid dehydration and death. Effective management requires early diagnosis and rehydration using oral rehydration salts or intravenous fluids. In this review, we evaluate the additional benefits of treating cholera with antimicrobial drugs. OBJECTIVES: To quantify the benefit of antimicrobial treatment for patients with cholera, and determine whether there are differences between classes of antimicrobials or dosing schedules...
2014: Cochrane Database of Systematic Reviews
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