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https://www.readbyqxmd.com/read/29501819/emergence-of-ndm-5-producing-escherichia-coli-sequence-type-167-clone-in-italy
#1
Maria Giufrè, Giulia Errico, Marisa Accogli, Monica Monaco, Laura Villa, Maria Antonietta Distasi, Tito Del Gaudio, Annalisa Pantosti, Alessandra Carattoli, Marina Cerquetti
The emergence of carbapenemase-producing Enterobacteriaceae (CPE) is a critical concern worldwide. In Italy, CPE isolates are very frequent with the KPC types strongly predominant whereas the New Delhi metallo-β-lactamase (NDM) enzymes are extremely rare. In this study, we report the first detection of NDM-5-producing Escherichia coli sequence type (ST) 167 isolates from two patients with urinary tract infection (Ec001and Ec002 from urines) including one with colonization (Ec003 from faeces) admitted to the same hospital in 2017 two months apart...
February 28, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29444730/outbreak-of-st395-kpc-producing-klebsiella-pneumoniae-in-a-neonatal-intensive-care-unit-in-palermo-italy
#2
Carmelo M Maida, Celestino Bonura, Daniela M Geraci, Giorgio Graziano, Alessandra Carattoli, Angelo Rizzo, Maria V Torregrossa, Davide Vecchio, Mario Giuffrè
No abstract text is available yet for this article.
February 15, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29439754/multiplex-pcr-for-detection-of-plasmid-mediated-colistin-resistance-determinants-mcr-1-mcr-2-mcr-3-mcr-4-and-mcr-5-for-surveillance-purposes
#3
Ana Rita Rebelo, Valeria Bortolaia, Jette S Kjeldgaard, Susanne K Pedersen, Pimlapas Leekitcharoenphon, Inge M Hansen, Beatriz Guerra, Burkhard Malorny, Maria Borowiak, Jens Andre Hammerl, Antonio Battisti, Alessia Franco, Patricia Alba, Agnes Perrin-Guyomard, Sophie A Granier, Cristina De Frutos Escobar, Surbhi Malhotra-Kumar, Laura Villa, Alessandra Carattoli, Rene S Hendriksen
Background and aimPlasmid-mediated colistin resistance mechanisms have been identified worldwide in the past years. A multiplex polymerase chain reaction (PCR) protocol for detection of all currently known transferable colistin resistance genes ( mcr-1 to mcr-5 , and variants) in Enterobacteriaceae was developed for surveillance or research purposes. Methods: We designed four new primer pairs to amplify mcr-1 , mcr-2 , mcr-3 and mcr-4 gene products and used the originally described primers for mcr-5 to obtain a stepwise separation of ca 200 bp between amplicons...
February 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29338810/detection-of-mcr-4-positive-s-almonella-enterica-serovar-typhimurium-in-clinical-isolates-of-human-origin-italy-october-to-november-2016
#4
Edoardo Carretto, Flavia Brovarone, Paola Nardini, Giuseppe Russello, Daniela Barbarini, Stefano Pongolini, Carlo Gagliotti, Alessandra Carattoli, Mario Sarti
In this study we report the detection of the recently described mcr-4 gene in two human isolates of Salmonella enterica serovar Typhimurium. The strains were isolated from faecal samples of two Italian patients with gastroenteritis, collected in 2016. The identified mcr-4 genes (variant mcr-4.2 ) differed from the mcr-4 gene originally described in a Salmonella strain of swine origin from Italy. Salmonella species could represent a hidden reservoir for mcr genes.
January 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28797329/novel-plasmid-mediated-colistin-resistance-mcr-4-gene-in-salmonella-and-escherichia-coli-italy-2013-spain-and-belgium-2015-to-2016
#5
Alessandra Carattoli, Laura Villa, Claudia Feudi, Ludovica Curcio, Serenella Orsini, Andrea Luppi, Giovanni Pezzotti, Chiara Francesca Magistrali
A novel mcr colistin resistance gene was identified in a strain of Salmonella enterica, monophasic variant of serovar Typhimurium (4,5,12:i:- ), isolated from a pig at slaughter in Italy in 2013, and in Escherichia coli strains collected during routine diagnostic of post-weaning diarrhoea in pigs from Spain and Belgium in 2015 and 2016. Immediate implementation of mcr-screening including this novel gene variant is required for Salmonella and E. coli from humans and food-producing animals in Europe.
August 3, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28559268/circulation-of-bla-kpc-3-carrying-incx3-plasmids-among-citrobacter-freundii-isolates-in-an-italian-hospital
#6
Carolina Venditti, Daniela Fortini, Laura Villa, Antonella Vulcano, Silvia D'Arezzo, Alessandro Capone, Nicola Petrosillo, Carla Nisii, Alessandra Carattoli, Antonino Di Caro
Colonizations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in health care settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a 3-year surveillance program. bla KPC-3 -carrying plasmids were found to belong to the IncX3 group in 9 of the 11 strains, and complete nucleotide sequences were obtained for 2 of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes...
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28521338/klebsiella-pneumoniae-a-major-worldwide-source-and-shuttle-for-antibiotic-resistance
#7
REVIEW
Shiri Navon-Venezia, Kira Kondratyeva, Alessandra Carattoli
Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs). Under antibiotic selective pressure, K. pneumoniae continuously accumulates ARGs, by de novo mutations, and via acquisition of plasmids and transferable genetic elements, leading to extremely drug resistant (XDR) strains harboring a 'super resistome'...
May 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28360894/plasmids-carrying-blacmy-2-4-in-escherichia-coli-from-poultry-poultry-meat-and-humans-belong-to-a-novel-inck-subgroup-designated-inck2
#8
Salome N Seiffert, Alessandra Carattoli, Sybille Schwendener, Alexandra Collaud, Andrea Endimiani, Vincent Perreten
The blaCMY -2/4-carrying IncB/O/K-like plasmids of seven Escherichia coli strains from poultry, poultry meat and human urine samples were examined using comparative analysis of whole plasmid sequences. The incompatibility group was determined by analysis of the incRNAI region and conjugation assays with strains containing the IncK and IncB/O reference plasmids. Strains were additionally characterized using MLST and MIC determination. The complete DNA sequences of all plasmids showed an average nucleotide identity of 91...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28201713/escherichia-coli-an-old-friend-with-new-tidings
#9
REVIEW
J Vila, E Sáez-López, J R Johnson, U Römling, U Dobrindt, R Cantón, C G Giske, T Naas, A Carattoli, M Martínez-Medina, J Bosch, P Retamar, J Rodríguez-Baño, F Baquero, S M Soto
Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background...
July 1, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28156193/characterization-of-ndm-7-carbapenemase-producing-escherichia-coli-isolates-in-the-arabian-peninsula
#10
Tibor Pál, Akela Ghazawi, Dania Darwish, Laura Villa, Alessandra Carattoli, Rayhan Hashmey, Zulfa Aldeesi, Wafaa Jamal, Vincent Rotimi, Amina Al-Jardani, Seif S Al-Abri, Ágnes Sonnevend
AIM: The purpose of this study was to characterize the New Delhi metallo-beta lactamase (NDM)-7-producing Enterobacteriaceae isolated in the Arabian Peninsula. METHODS: Enterobacteriaceae identified to carry blaNDM-7 in a collection of 157 NDM-producing isolates from Kuwait, Oman, Saudi Arabia, and the United Arab Emirates (UAE) were investigated for their antibiotic and disinfectant susceptibility, and resistance gene content. The virulence profile, phylogenetic and sequence types of the isolates were also determined...
October 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28137396/comparative-analysis-of-the-standard-pcr-based-replicon-typing-pbrt-with-the-commercial-pbrt-kit
#11
Elisa Carloni, Francesca Andreoni, Enrica Omiccioli, Laura Villa, Mauro Magnani, Alessandra Carattoli
Plasmids are the main vectors of resistance and virulence genes in Enterobacteriaceae and plasmid typing is essential for the analysis of evolution, epidemiology and spread of antibacterial resistance. The PCR-Based Replicon Typing (PBRT), developed by Carattoli et al. in 2005, was an efficient method for plasmid identification and typing in Enterobacteriaceae. The 2005 PBRT scheme detected 18 replicons in 8 PCR reactions. Recently, the identification of novel replicons and plasmid types requested an update of the PBRT scheme...
March 2017: Plasmid
https://www.readbyqxmd.com/read/27919902/genetic-environment-of-the-blakpc-2-gene-in-a-klebsiella-pneumoniae-isolate-that-may-have-been-imported-to-russia-from-southeast-asia
#12
Vladimir Ageevets, Julia Sopova, Irina Lazareva, Maya Malakhova, Elena Ilina, Elena Kostryukova, Vladislav Babenko, Alessandra Carattoli, Yuri Lobzin, Alexander Uskov, Sergey Sidorenko
The nucleotide sequence of a blaKPC-2-harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. blaKPC-2 was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn3 repeats and included a Tn3-specific transposase gene, macrolide resistance operon (mphA-mrx-mphR), and a fragment of blaTEM with unique polymorphisms...
February 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27297483/travelers-can-import-colistin-resistant-enterobacteriaceae-including-those-possessing-the-plasmid-mediated-mcr-1-gene
#13
Odette J Bernasconi, Esther Kuenzli, João Pires, Regula Tinguely, Alessandra Carattoli, Christoph Hatz, Vincent Perreten, Andrea Endimiani
Stool samples from 38 travelers returning from India were screened for extended-spectrum cephalosporin- and carbapenem-resistant Enterobacteriaceae implementing standard selective plates. Twenty-six (76.3%) people were colonized with CTX-M or DHA producers, but none of the strains was colistin resistant and/or mcr-1 positive. Nevertheless, using overnight enrichment and CHROMagar Orientation plates supplemented with colistin, four people (10.5%) were found to be colonized with colistin-resistant Escherichia coli One cephalosporin-susceptible sequence type 10 (ST10) strain carried a 4,211-bp ISApl1-mcr-1-ISApl1 element in an IncHI2 plasmid backbone...
August 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27284988/isolation-of-kpc-3-producing-enterobacter-aerogenes-in-a-patient-colonized-by-mdr-klebsiella-pneumoniae
#14
Carolina Venditti, Laura Villa, Alessandro Capone, Daniela Fortini, Silvia D'Arezzo, Carla Nisii, Eugenio Bordi, Vincenzo Puro, Mario Antonini, Alessandra Carattoli, Maria Adriana Cataldo, Nicola Petrosillo, Antonino Di Caro
We describe the interspecies transmission of the plasmid-mediated blaKPC-3 gene, which confers carbapenem resistance, between clinically relevant gram-negative bacteria in a single patient. A KPC-3 producing Enterobacter aerogenes was isolated from a hospitalized patient previously colonized and then infected by a Klebsiella pneumoniae ST101 carrying the blaKPC-3 gene. The strains showed identical plasmids. Since intense horizontal exchanges among bacteria can occur in the gut, clinicians should be aware that patients colonized by carbapenem-resistant K...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27056222/complete-genome-sequence-of-kpc-3-and-ctx-m-15-producing-klebsiella-pneumoniae-sequence-type-307
#15
Laura Villa, Claudia Feudi, Daniela Fortini, Michele Iacono, Celestino Bonura, Andrea Endimiani, Caterina Mammina, Alessandra Carattoli
Klebsiella pneumoniaesequence type (ST) 307, carryingblaKPC-3,blaCTX-M-15,blaOXA-1,aac(6')-Ib-cr, andqnrB1 genes, is replacing the predominant hyperepidemic ST258 clone in Italy. Whole-genome and complete plasmid sequencing of one ST307 strain was performed and new features were identified.
2016: Genome Announcements
https://www.readbyqxmd.com/read/26961094/escherichia-coli-an-old-friend-with-new-tidings
#16
REVIEW
J Vila, E Sáez-López, J R Johnson, U Römling, U Dobrindt, R Cantón, C G Giske, T Naas, A Carattoli, M Martínez-Medina, J Bosch, P Retamar, J Rodríguez-Baño, F Baquero, S M Soto
Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background...
March 8, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/26525794/double-copies-of-bla-kpc-3-tn4401a-on-an-incx3-plasmid-in-klebsiella-pneumoniae-successful-clone-st512-from-italy
#17
Daniela Fortini, Laura Villa, Claudia Feudi, João Pires, Celestino Bonura, Caterina Mammina, Andrea Endimiani, Alessandra Carattoli
A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid...
January 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26442177/integration-of-erm-b-containing-elements-through-large-chromosome-fragment-exchange-in-clostridium-difficile
#18
François Wasels, Patrizia Spigaglia, Fabrizio Barbanti, Marc Monot, Laura Villa, Bruno Dupuy, Alessandra Carattoli, Paola Mastrantonio
In Clostridium difficile, erm(B) genes are located on mobile elements like Tn5398 and Tn6215. In previous studies, some of these elements were transferred by conjugation-like mechanisms, mobilized in trans by helper conjugative systems. In this study, we analyzed the genomes of several recipient strains that acquired either Tn5398 or Tn6215-like elements. We demonstrated that the integration of the transposons in the genome of the recipient cell was always due to homologous recombination events, involving exchange of large chromosomal segments...
January 2015: Mobile Genetic Elements
https://www.readbyqxmd.com/read/26248381/characterization-of-an-enterobacter-cloacae-strain-producing-both-kpc-and-ndm-carbapenemases-by-whole-genome-sequencing
#19
Wenjing Wu, Yu Feng, Alessandra Carattoli, Zhiyong Zong
A carbapenem-resistant Enterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes, blaNDM-1 and blaKPC-2, on separate IncF plasmids. The coexistence of blaNDM-1 and blaKPC-2 conferred slightly higher-level carbapenem resistance compared with that of blaNDM-1 or blaKPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes...
October 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26169417/inca-c-plasmid-carrying-bla-ndm-1-bla-cmy-16-and-fosa3-in-a-salmonella-enterica-serovar-corvallis-strain-isolated-from-a-migratory-wild-bird-in-germany
#20
L Villa, B Guerra, S Schmoger, J Fischer, R Helmuth, Z Zong, A García-Fernández, A Carattoli
A Salmonella enterica serovar Corvallis strain was isolated from a wild bird in Germany. This strain carried the IncA/C2 pRH-1238 plasmid. Complete sequencing of the plasmid was performed, identifying the blaNDM-1, blaCMY-16, fosA3, sul1, sul2, strA, strB, aac(6')-Ib, aadA5, aphA6, tetA(A), mphA, floR, dfrA7, and merA genes, which confer clinically relevant resistance to most of the antimicrobial classes, including β-lactams with carbapenems, fosfomycin, aminoglycosides, co-trimoxazole, tetracyclines, and macrolides...
October 2015: Antimicrobial Agents and Chemotherapy
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