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https://www.readbyqxmd.com/read/28559268/circulation-of-blakpc-3-carrying-incx3-plasmids-among-c-freundii-isolates-in-an-italian-hospital
#1
Carolina Venditti, Daniela Fortini, Laura Villa, Antonella Vulcano, Silvia D'Arezzo, Alessandro Capone, Nicola Petrosillo, Carla Nisii, Alessandra Carattoli, Antonino Di Caro
Colonisations due to carbapenem-resistant Enterobacteriaceae (CRE) are a source of antimicrobial resistance transmission in healthcare settings. Eleven Citrobacter freundii strains producing KPC-3 carbapenemase were isolated from rectal swabs during a three-year surveillance programme. In 9/11 strains, blaKPC-3-carrying plasmids were found to belong to the IncX3 group and complete nucleotide sequences were obtained for two of them. Our results highlight the possible role of C. freundii as reservoir of resistance genes...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28521338/klebsiella-pneumoniae-a-major-worldwide-source-and-shuttle-for-antibiotic-resistance
#2
Shiri Navon-Venezia, Kira Kondratyeva, Alessandra Carattoli
Klebsiella pneumoniae is an important multidrug-resistant (MDR) pathogen affecting humans and a major source for hospital infections associated with high morbidity and mortality due to limited treatment options. We summarize the wide resistome of this pathogen, which encompasses plentiful chromosomal and plasmid-encoded antibiotic resistance genes (ARGs). Under antibiotic selective pressure, K. pneumoniae continuously accumulates ARGs, by de novo mutations, and via acquisition of plasmids and transferable genetic elements, leading to extremely drug resistant (XDR) strains harboring a 'super resistome'...
May 1, 2017: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28360894/plasmids-carrying-blacmy-2-4-in-escherichia-coli-from-poultry-poultry-meat-and-humans-belong-to-a-novel-inck-subgroup-designated-inck2
#3
Salome N Seiffert, Alessandra Carattoli, Sybille Schwendener, Alexandra Collaud, Andrea Endimiani, Vincent Perreten
The blaCMY -2/4-carrying IncB/O/K-like plasmids of seven Escherichia coli strains from poultry, poultry meat and human urine samples were examined using comparative analysis of whole plasmid sequences. The incompatibility group was determined by analysis of the incRNAI region and conjugation assays with strains containing the IncK and IncB/O reference plasmids. Strains were additionally characterized using MLST and MIC determination. The complete DNA sequences of all plasmids showed an average nucleotide identity of 91...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28201713/escherichia-coli-an-old-friend-with-new-tidings
#4
J Vila, E Sáez-López, J R Johnson, U Römling, U Dobrindt, R Cantón, C G Giske, T Naas, A Carattoli, M Martínez-Medina, J Bosch, P Retamar, J Rodríguez-Baño, F Baquero, S M Soto
No abstract text is available yet for this article.
July 1, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/28156193/characterization-of-ndm-7-carbapenemase-producing-escherichia-coli-isolates-in-the-arabian-peninsula
#5
Tibor Pál, Akela Ghazawi, Dania Darwish, Laura Villa, Alessandra Carattoli, Rayhan Hashmey, Zulfa Aldeesi, Wafaa Jamal, Vincent Rotimi, Amina Al-Jardani, Seif S Al-Abri, Ágnes Sonnevend
AIM: The purpose of this study was to characterize the New Delhi metallo-beta lactamase (NDM)-7-producing Enterobacteriaceae isolated in the Arabian Peninsula. METHODS: Enterobacteriaceae identified to carry blaNDM-7 in a collection of 157 NDM-producing isolates from Kuwait, Oman, Saudi Arabia, and the United Arab Emirates (UAE) were investigated for their antibiotic and disinfectant susceptibility, and resistance gene content. The virulence profile, phylogenetic and sequence types of the isolates were also determined...
February 3, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28137396/comparative-analysis-of-the-standard-pcr-based-replicon-typing-pbrt-with-the-commercial-pbrt-kit
#6
Elisa Carloni, Francesca Andreoni, Enrica Omiccioli, Laura Villa, Mauro Magnani, Alessandra Carattoli
Plasmids are the main vectors of resistance and virulence genes in Enterobacteriaceae and plasmid typing is essential for the analysis of evolution, epidemiology and spread of antibacterial resistance. The PCR-Based Replicon Typing (PBRT), developed by Carattoli et al. in 2005, was an efficient method for plasmid identification and typing in Enterobacteriaceae. The 2005 PBRT scheme detected 18 replicons in 8 PCR reactions. Recently, the identification of novel replicons and plasmid types requested an update of the PBRT scheme...
March 2017: Plasmid
https://www.readbyqxmd.com/read/27919902/genetic-environment-of-the-blakpc-2-gene-in-a-klebsiella-pneumoniae-isolate-that-may-have-been-imported-to-russia-from-southeast-asia
#7
Vladimir Ageevets, Julia Sopova, Irina Lazareva, Maya Malakhova, Elena Ilina, Elena Kostryukova, Vladislav Babenko, Alessandra Carattoli, Yuri Lobzin, Alexander Uskov, Sergey Sidorenko
The nucleotide sequence of a blaKPC-2-harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. blaKPC-2 was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn3 repeats and included a Tn3-specific transposase gene, macrolide resistance operon (mphA-mrx-mphR), and a fragment of blaTEM with unique polymorphisms...
February 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27297483/travelers-can-import-colistin-resistant-enterobacteriaceae-including-those-possessing-the-plasmid-mediated-mcr-1-gene
#8
Odette J Bernasconi, Esther Kuenzli, João Pires, Regula Tinguely, Alessandra Carattoli, Christoph Hatz, Vincent Perreten, Andrea Endimiani
Stool samples from 38 travelers returning from India were screened for extended-spectrum cephalosporin- and carbapenem-resistant Enterobacteriaceae implementing standard selective plates. Twenty-six (76.3%) people were colonized with CTX-M or DHA producers, but none of the strains was colistin resistant and/or mcr-1 positive. Nevertheless, using overnight enrichment and CHROMagar Orientation plates supplemented with colistin, four people (10.5%) were found to be colonized with colistin-resistant Escherichia coli One cephalosporin-susceptible sequence type 10 (ST10) strain carried a 4,211-bp ISApl1-mcr-1-ISApl1 element in an IncHI2 plasmid backbone...
August 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27284988/isolation-of-kpc-3-producing-enterobacter-aerogenes-in-a-patient-colonized-by-mdr-klebsiella-pneumoniae
#9
Carolina Venditti, Laura Villa, Alessandro Capone, Daniela Fortini, Silvia D'Arezzo, Carla Nisii, Eugenio Bordi, Vincenzo Puro, Mario Antonini, Alessandra Carattoli, Maria Adriana Cataldo, Nicola Petrosillo, Antonino Di Caro
We describe the interspecies transmission of the plasmid-mediated blaKPC-3 gene, which confers carbapenem resistance, between clinically relevant gram-negative bacteria in a single patient. A KPC-3 producing Enterobacter aerogenes was isolated from a hospitalized patient previously colonized and then infected by a Klebsiella pneumoniae ST101 carrying the blaKPC-3 gene. The strains showed identical plasmids. Since intense horizontal exchanges among bacteria can occur in the gut, clinicians should be aware that patients colonized by carbapenem-resistant K...
October 2016: New Microbiologica
https://www.readbyqxmd.com/read/27056222/complete-genome-sequence-of-kpc-3-and-ctx-m-15-producing-klebsiella-pneumoniae-sequence-type-307
#10
Laura Villa, Claudia Feudi, Daniela Fortini, Michele Iacono, Celestino Bonura, Andrea Endimiani, Caterina Mammina, Alessandra Carattoli
Klebsiella pneumoniaesequence type (ST) 307, carryingblaKPC-3,blaCTX-M-15,blaOXA-1,aac(6')-Ib-cr, andqnrB1 genes, is replacing the predominant hyperepidemic ST258 clone in Italy. Whole-genome and complete plasmid sequencing of one ST307 strain was performed and new features were identified.
2016: Genome Announcements
https://www.readbyqxmd.com/read/26961094/escherichia-coli-an-old-friend-with-new-tidings
#11
REVIEW
J Vila, E Sáez-López, J R Johnson, U Römling, U Dobrindt, R Cantón, C G Giske, T Naas, A Carattoli, M Martínez-Medina, J Bosch, P Retamar, J Rodríguez-Baño, F Baquero, S M Soto
Escherichia coli is one of the most-studied microorganisms worldwide but its characteristics are continually changing. Extraintestinal E. coli infections, such as urinary tract infections and neonatal sepsis, represent a huge public health problem. They are caused mainly by specialized extraintestinal pathogenic E. coli (ExPEC) strains that can innocuously colonize human hosts but can also cause disease upon entering a normally sterile body site. The virulence capability of such strains is determined by a combination of distinctive accessory traits, called virulence factors, in conjunction with their distinctive phylogenetic background...
March 8, 2016: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/26525794/double-copies-of-bla-kpc-3-tn4401a-on-an-incx3-plasmid-in-klebsiella-pneumoniae-successful-clone-st512-from-italy
#12
Daniela Fortini, Laura Villa, Claudia Feudi, João Pires, Celestino Bonura, Caterina Mammina, Andrea Endimiani, Alessandra Carattoli
A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla(KPC) genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla(KPC-3) gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla(KPC-3)::Tn4401a caused by intramolecular transposition events were detected in the plasmid...
January 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26442177/integration-of-erm-b-containing-elements-through-large-chromosome-fragment-exchange-in-clostridium-difficile
#13
François Wasels, Patrizia Spigaglia, Fabrizio Barbanti, Marc Monot, Laura Villa, Bruno Dupuy, Alessandra Carattoli, Paola Mastrantonio
In Clostridium difficile, erm(B) genes are located on mobile elements like Tn5398 and Tn6215. In previous studies, some of these elements were transferred by conjugation-like mechanisms, mobilized in trans by helper conjugative systems. In this study, we analyzed the genomes of several recipient strains that acquired either Tn5398 or Tn6215-like elements. We demonstrated that the integration of the transposons in the genome of the recipient cell was always due to homologous recombination events, involving exchange of large chromosomal segments...
January 2015: Mobile Genetic Elements
https://www.readbyqxmd.com/read/26248381/characterization-of-an-enterobacter-cloacae-strain-producing-both-kpc-and-ndm-carbapenemases-by-whole-genome-sequencing
#14
Wenjing Wu, Yu Feng, Alessandra Carattoli, Zhiyong Zong
A carbapenem-resistant Enterobacter cloacae strain, WCHECl-14653, causing a fatal bloodstream infection, was characterized by genome sequencing and conjugation experiments. The strain carried two carbapenemase genes, blaNDM-1 and blaKPC-2, on separate IncF plasmids. The coexistence of blaNDM-1 and blaKPC-2 conferred slightly higher-level carbapenem resistance compared with that of blaNDM-1 or blaKPC-2 alone, and the coexistence of two IncF plasmids may generate new platforms for spreading carbapenemase genes...
October 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/26169417/inca-c-plasmid-carrying-bla-ndm-1-bla-cmy-16-and-fosa3-in-a-salmonella-enterica-serovar-corvallis-strain-isolated-from-a-migratory-wild-bird-in-germany
#15
L Villa, B Guerra, S Schmoger, J Fischer, R Helmuth, Z Zong, A García-Fernández, A Carattoli
A Salmonella enterica serovar Corvallis strain was isolated from a wild bird in Germany. This strain carried the IncA/C2 pRH-1238 plasmid. Complete sequencing of the plasmid was performed, identifying the blaNDM-1, blaCMY-16, fosA3, sul1, sul2, strA, strB, aac(6')-Ib, aadA5, aphA6, tetA(A), mphA, floR, dfrA7, and merA genes, which confer clinically relevant resistance to most of the antimicrobial classes, including β-lactams with carbapenems, fosfomycin, aminoglycosides, co-trimoxazole, tetracyclines, and macrolides...
October 2015: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/25933288/differentiation-of-incl-and-incm-plasmids-associated-with-the-spread-of-clinically-relevant-antimicrobial-resistance
#16
Alessandra Carattoli, Salome N Seiffert, Sybille Schwendener, Vincent Perreten, Andrea Endimiani
INTRODUCTION: blaOXA-48, blaNDM-1 and blaCTX-M-3 are clinically relevant resistance genes, frequently associated with the broad-host range plasmids of the IncL/M group. The L and M plasmids belong to two compatible groups, which were incorrectly classified together by molecular methods. In order to understand their evolution, we fully sequenced four IncL/M plasmids, including the reference plasmids R471 and R69, the recently described blaOXA-48-carrying plasmid pKPN-El.Nr7 from a Klebsiella pneumoniae isolated in Bern (Switzerland), and the blaSHV-5 carrying plasmid p202c from a Salmonella enterica from Tirana (Albania)...
2015: PloS One
https://www.readbyqxmd.com/read/25123809/emergence-of-klebsiella-pneumoniae-co-producing-ndm-1-oxa-48-ctx-m-15-cmy-16-qnra-and-arma-in-switzerland
#17
Salome N Seiffert, Jonas Marschall, Vincent Perreten, Alessandra Carattoli, Hansjakob Furrer, Andrea Endimiani
Extensively drug-resistant (XDR) Klebsiella pneumoniae isolates usually carry a single carbapenemase (e.g. KPC, NDM, OXA-48-like). Here we describe an XDR K. pneumoniae of sequence type 101 that was detected in the screening rectal swab of a patient transferred from the intensive care unit of a hospital located in Belgrade (Serbia) to Bern University Hospital (Switzerland). The isolate was resistant to all antibiotics with the exception of colistin [minimum inhibitory concentration] (MIC ≤ 0.125 μg/mL), tigecycline (MIC = 0...
September 2014: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/25092703/high-prevalence-of-extended-spectrum-%C3%AE-lactamase-plasmid-mediated-ampc-and-carbapenemase-genes-in-pet-food
#18
Salome N Seiffert, Alessandra Carattoli, Regula Tinguely, Agnese Lupo, Vincent Perreten, Andrea Endimiani
We evaluated the pet food contained in 30 packages as a potential origin of extended-spectrum cephalosporin-resistant Gram-negative organisms and β-lactamase genes (bla). Live bacteria were not detected by selective culture. However, PCR investigations on food DNA extracts indicated that samples harbored the blaCTX-M-15 (53.3%), blaCMY-4 (20%), and blaVEB-4-like (6.7%) genes. Particularly worrisome was the presence of blaOXA-48-like carbapenemases (13.3%). The original pet food ingredients and/or the production processes were highly contaminated with bacteria carrying clinically relevant acquired bla genes...
October 2014: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/24957829/long-term-dissemination-of-ctx-m-5-producing-hypermutable-salmonella-enterica-serovar-typhimurium-sequence-type-328-strains-in-russia-belarus-and-kazakhstan
#19
Varvara K Kozyreva, Elena N Ilina, Maja V Malakhova, Alessandra Carattoli, Ilya S Azizov, Dmitry V Tapalski, Roman S Kozlov, Mikhail V Edelstein
In this paper, we present evidence of long-term circulation of cefotaxime-resistant clonally related Salmonella enterica serovar Typhimurium strains over a broad geographic area. The genetic relatedness of 88 isolates collected from multiple outbreaks and sporadic cases of nosocomial salmonellosis in various parts of Russia, Belarus, and Kazakhstan from 1996 to 2009 was established by multilocus tandem-repeat analysis (MLVA) and multilocus sequence typing (MLST). The isolates belong to sequence type 328 (ST328) and produce CTX-M-5 β-lactamase, whose gene is carried by highly related non-self-conjugative but mobilizable plasmids...
September 2014: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/24862095/complete-sequences-of-inchi1-plasmids-carrying-blactx-m-1-and-qnrs1-in-equine-escherichia-coli-provide-new-insights-into-plasmid-evolution
#20
Monika Dolejska, Laura Villa, Marco Minoia, Luca Guardabassi, Alessandra Carattoli
OBJECTIVES: To determine the structure of two multidrug-resistant IncHI1 plasmids carrying blaCTX-M-1 in Escherichia coli isolates disseminated in an equine clinic in the Czech Republic. METHODS: A complete nucleotide sequencing of 239 kb IncHI1 (pEQ1) and 287 kb IncHI1/X1 (pEQ2) plasmids was performed using the 454-Genome Sequencer FLX system. The sequences were compared using bioinformatic tools with other sequenced IncHI1 plasmids. RESULTS: A comparative analysis of pEQ1 and pEQ2 identified high nucleotide identity with the IncHI1 type 2 plasmids...
September 2014: Journal of Antimicrobial Chemotherapy
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