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https://www.readbyqxmd.com/read/28330410/outcome-and-management-of-refractory-respiratory-failure-with-timely-extracorporeal-membrane-oxygenationsingle-center-experience-with-legionella-pneumonia
#1
Roberto Roncon-Albuquerque, Rodrigo Vilares-Morgado, Gert-Jan van der Heijden, João Ferreira-Coimbra, Paulo Mergulhão, José Artur Paiva
OBJECTIVE: To analyze the management and outcome of patients with refractory respiratory failure complicating severe Legionella pneumonia rescued with extracorporeal membrane oxygenation (ECMO) in our Center. DESIGN AND SETTING: Observational study of patients with refractory respiratory failure treated with ECMO in Hospital S.João (Porto, Portugal), between November 2009 and September 2016. PARTICIPANTS: A total of 112 patients rescued with ECMO, of which 14 had Legionella pneumonia...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28330216/potential-application-of-waste-from-castor-bean-ricinus-communis-l-for-production-for-xylanase-of-interest-in-the-industry
#2
Polyanna Nunes Herculano, Keila Aparecida Moreira, Raquel Pedrosa Bezerra, Tatiana Souza Porto, Cristina Maria de Souza-Motta, Ana Lúcia Figueiredo Porto
Xylanases activity (XY) from Aspergillus japonicus URM5620 produced by Solid-State Fermentation (SSF) of castor press cake (Ricinus communis) on different conditions of production and extraction by PEG/citrate aqueous two-phase system (ATPS) were investigated. XY production was influenced by substrate amount (5-10 g), initial moisture (15-35 %), pH (4.0-6.0) and temperature (25-35 °C), obtaining the maximum activity of 29,085 ± 1808 U g ds(-1) using 5.0 g of substrate with initial moisture of 15 % at 25 °C and pH 6...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28327798/molecular-and-clinical-epidemiological-surveillance-of-dengue-virus-in-para%C3%A3-ba-northeast-brazil
#3
Isabel Cristina Guerra-Gomes, Bruna Macêdo Gois, Rephany Fonseca Peixoto, Camila Alves Oliveira, Bruna Leal Lima Maciel, Maria Izabel Ferreira Sarmento, Anna Stella Cysneiros Pachá, Josélio Maria Galvão Araújo, Ian Porto Gurgel Amaral, Tatjana Souza Lima Keesen
INTRODUCTION: Despite being the most prevalent arboviral disease worldwide, dengue has been neglected lately. However, recent epidemics of arboviruses such as Zika and chikungunya in locations throughout the world have alerted health authorities to these diseases. This study evaluated the incidence pattern of dengue, its clinical characteristics, and co-circulation of serotypes from 2007 to 2015 in Paraiba State, Northeast Brazil. METHODS: Data on dengue cases from 2007 to 2015 were extracted from clinical reports of the National System for Notifiable Diseases [Sistema Nacional de Agravos de Notificação (SINAN)] of Brazil provided by the Paraiba Health Department...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327789/prevalence-of-hepatitis-c-virus-and-human-immunodeficiency-virus-in-a-group-of-patients-newly-diagnosed-with-active-tuberculosis-in-porto-alegre-southern-brazil
#4
Cintia Costi, Tarciana Grandi, Maria Laura Halon, Márcia Susana Nunes Silva, Cláudia Maria Dornelles da Silva, Tatiana Schäffer Gregianini, Lia Gonçalves Possuelo, Carla Adriane Jarczewski, Christian Niel, Maria Lucia Rosa Rossetti
BACKGROUND: Porto Alegre is the Brazilian state capital with second highest incidence of tuberculosis (TB) and the highest proportion of people infected with human immunodeficiency virus (HIV) among patients with TB. Hepatitis C virus (HCV) infection increases the risk of anti-TB drug-induced hepatotoxicity, which may result in discontinuation of the therapy. OBJECTIVES: The aim of this study was (i) to estimate prevalence of HCV and HIV in a group of patients newly diagnosed with active TB in a public reference hospital in Porto Alegre and (ii) to compare demographic, behavioural, and clinical characteristics of patients in relation to their HCV infection status...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28321379/differentiation-between-posterior-sinuses-using-the-medial-orbital-floor-as-a-landmark
#5
Camila Degen Meotti, Otávio Bejzman Piltcher, Bruno Netto, Jaqueline Lemieszek, Michelle Lavinsky-Wolff, Felipe Marques do Rego Monteiro, Gustavo Rassier Isolan
Objectives This study aims to evaluate the difference in height between the floors of the posterior ethmoid and sphenoid sinuses with respect to the medial orbital floor (MOF) to confirm this difference as a landmark for identification of the posterior sinuses. It also aims to describe this difference regarding the type of pneumatization of the sphenoid sinus (conchal, presellar, and sellar). Design A cross-sectional study was conducted. Study Center The study was conducted at the Department of Radiology of Hospital de Clínicas de Porto Alegre, a tertiary care university hospital in Southern Brazil...
April 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28288562/genetic-diversity-and-signatures-of-selection-in-various-goat-breeds-revealed-by-genome-wide-snp-markers
#6
Luiz F Brito, James W Kijas, Ricardo V Ventura, Mehdi Sargolzaei, Laercio R Porto-Neto, Angela Cánovas, Zeny Feng, Mohsen Jafarikia, Flávio S Schenkel
BACKGROUND: The detection of signatures of selection has the potential to elucidate the identities of genes and mutations associated with phenotypic traits important for livestock species. It is also very relevant to investigate the levels of genetic diversity of a population, as genetic diversity represents the raw material essential for breeding and has practical implications for implementation of genomic selection. A total of 1151 animals from nine goat populations selected for different breeding goals and genotyped with the Illumina Goat 50K single nucleotide polymorphisms (SNP) Beadchip were included in this investigation...
March 14, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28286612/characterization-of-patients-with-chronic-myeloid-leukemia-unresponsive-to-tyrosine-kinase-inhibitors-who-underwent-allogeneic-hematopoietic-stem-cell-transplantation
#7
Franceli Ramos Carvalho, Joice Zuckermann, Alessandra Paz, Gustavo Fischer, Liane Esteves Daudt, Lisandra Della Costa Rigoni, Lúcia Silla, Laura Fogliatto, Simone Martins de Castro, Diogo André Pilger
Background: Tyrosine kinase inhibitors (TKIs) were the first drugs to use an intracellular signaling molecule as a therapeutic target. Unresponsiveness to TKIs limits therapeutic options, making allogeneic hematopoietic stem cell transplantation (HSCT) the only option leading to molecular remission. The aim of this study is to characterize CML patients unresponsive to first- and/or second-generation TKI therapy who underwent HSCT and to describe the main factors associated with treatment failure. Subjects and Methods: Twenty one CML patients who underwent allogeneic HSCT and had previously used first- and/or second-generation TKIs from January 2005 to May 2014...
January 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28284993/pediococcus-spp-an-important-genus-of-lactic-acid-bacteria-and-pediocin-producers
#8
REVIEW
Maria Carolina W Porto, Taís Mayumi Kuniyoshi, P O S Azevedo, Michele Vitolo, R P S Oliveira
Probiotics have gained increasing attention due to several health benefits related to the human digestive and immune systems. Pediococcus spp. are lactic acid bacteria (LAB) that are widely described as probiotics and characterized as coccus-shaped bacteria (arranged in tetrads), Gram-positive, non-motile, non-spore forming, catalase-negative, and facultative anaerobes. There are many Pediococcus strains that produce pediocin, an effective antilisterial bacteriocin. Pediocins are small, cationic molecules consisting of a conserved hydrophilic N-terminal portion containing the YGNGV motif and an amphiphilic or hydrophobic C-terminal variable portion...
March 8, 2017: Biotechnology Advances
https://www.readbyqxmd.com/read/28284888/characteristics-of-sleep-in-socially-vulnerable-adolescents
#9
Lisie Polita Romanzini, Aline Ávila Dos Santos, Magda Lahorgue Nunes
IMPORTANCE: This study may help understand the effects of an unfavorable environment in sleep quality of adolescents. OBJECTIVE: To investigate sleep quality in socially vulnerable adolescents, correlating the results with cognitive problems and attention deficit/hyperactivity disorder, and assessing the effectiveness of sleep hygiene and an educational intervention. DESIGN: Cross-sectional and interventional study. SETTING: an educational charitable center supported by a Catholic institution, in Porto Alegre, southern Brazil...
January 6, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28283444/comparison-between-simple-radiographic-and-computed-tomographic-three-dimensional-reconstruction-for-evaluation-of-the-distal-metatarsal-articular-angle
#10
Eduardo Pedrini Cruz, Felipe Victora Wagner, Carlo Henning, José Antônio Veiga Sanhudo, Fernando Pagnussato, Carlos Roberto Galia
The hallux valgus is a pathologic condition in the forefoot that often causes pain and functional limitations. Assessing all deformity components, such as the distal metatarsal articular angle (DMAA) is essential to hallux valgus treatment. Nevertheless, interobserver agreement of DMAA is poor on plain radiographs. The present study compared computed tomographic (CT) 3-dimensional (3D) reconstruction with plain radiographic measurements for measuring the DMAA. We included 43 consecutive patients (77 feet), diagnosed with hallux valgus at the orthopedic outpatient clinic at Hospital de Clínicas de Porto Alegre (Porto Alegre, Brazil) from April 2014 to June 2015 in our prospective study...
March 7, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28279149/somatic-growth-in-the-first-six-months-of-life-of-infants-exposed-to-maternal-smoking-in-pregnancy
#11
Mariana Lopes de Brito, Marina Nunes, Juliana Rombaldi Bernardi, Vera Lúcia Bosa, Marcelo Zubaran Goldani, Clécio Homrich da Silva
BACKGROUND: Some studies suggest a relationship between maternal smoking during pregnancy and not only intrauterine fetal growth restriction or low birth weight, but also with changes in the postnatal growth and development. The objective of the present study was to investigate the effects of smoking during pregnancy on infants growth in the first 6 months of life compared with a control group and a group with idiopathic intrauterine growth restriction. METHODS: Longitudinal observational study using a convenience sample of newborns divided into three groups: infants of smoking mothers (tobacco), with idiopathic intrauterine growth restriction (IUGR) and a control group...
March 9, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28277880/genomic-tests-to-guide-prostate-cancer-management-following-diagnosis
#12
Michele Colicchia, Alessandro Morlacco, John C Cheville, R Jeffrey Karnes
Prostate cancer (PCa) is a common cancer in men, but variable clinical behaviors make its management challenging. Risk stratification is a key issue in disease management. Patient-tailored strategies are strongly advocated to reduce unnecessary treatment while maximizing the oncological outcomes of patient who need active treatment in the primary, adjuvant or salvage setting. Recently, tissue-based biomarkers or genomic tests have become available to improve the clinical decision-making. Areas covered: In this review, the authors present recent evidence about these tissue-based biomarkers, discussing the application of each of them in the clinical setting, focusing on the tests aimed to provide a better risk stratification and to guide decision-making after the diagnosis of PCa (i...
March 13, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28270028/designing-and-evaluating-a-health-education-session-on-respiratory-infections-addressed-to-caregivers-of-children-under-three-years-of-age-attending-day-care-centres-in-porto-portugal-a-community-based-intervention
#13
Ana Manuela Ferreira da Silva Alexandrino, Rita Isabel Garrido Vieira Dos Santos, Maria Cristina Damas Argel de Melo, José Adelino Mesquita Bastos
BACKGROUND: Acute respiratory infections (ARI) are common in children, increasing the pressure on clinicians to prescribe antibiotics and affecting public health Objectives: This study aimed to design a health education session (HES) for caregivers of children, and to evaluate its effects on caregivers' needs, as well as on their knowledge and attitudes concerning ARI. METHODS: A generalized model of developing, implementing and evaluating a community-based intervention was followed, including caregivers of children under three years of age...
December 2017: European Journal of General Practice
https://www.readbyqxmd.com/read/28265173/shadow-moir%C3%A3-technique-for-postural-assessment-qualitative-assessment-protocol-by-intra-and-inter-rater-evaluation
#14
José Nunes da Silva Filho, Luiz Alberto Batista, Jonas Lírio Gurgel, Flávia Porto
[Purpose] This study aimed to develop and validate an assessment tool for Moiré topogram made specifically with the Shadow Moiré technique of the dorsum. [Subjects and Methods] In the analysis of topograms, frontal, sagittal, and transverse planes of individuals' dorsal were considered. Two instructor evaluators analyzed the topograms at different times in the day and on different days. The measurements of intra- and inter- (intra- and interday) reliability were calculated. [Results] Of the three planes analyzed, in all analyses, good (0...
February 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28264781/quantification-and-mapping-of-urban-fluxes-under-climate-change-application-of-wrf-suews-model-to-greater-porto-area-portugal
#15
S Rafael, H Martins, M Marta-Almeida, E Sá, S Coelho, A Rocha, C Borrego, M Lopes
Climate change and the growth of urban populations are two of the main challenges facing Europe today. These issues are linked as climate change results in serious challenges for cities. Recent attention has focused on how urban surface-atmosphere exchanges of heat and water will be affected by climate change and the implications for urban planning and sustainability. In this study energy fluxes for Greater Porto area, Portugal, were estimated and the influence of the projected climate change evaluated. To accomplish this, the Weather Research and Forecasting Model (WRF) and the Surface Urban Energy and Water Balance Scheme (SUEWS) were applied for two climatological scenarios: a present (or reference, 1986-2005) scenario and a future scenario (2046-2065), in this case the Representative Concentration Pathway RCP8...
May 2017: Environmental Research
https://www.readbyqxmd.com/read/28264142/using-body-donor-demographics-to-assist-the-implementation-of-donation-programs-in-brazil
#16
Andrea Oxley da Rocha, Deivis de Campos, Marco Aurélio Farina, Gabriel Sartori Pacini, Marina Cornelli Girotto, Arlete Hilbig
The use of human material in anatomy education depends upon the generosity of body donors. However, little is known regarding the demographics of body donors in Brazil, where voluntary body donation is a relatively rare phenomenon. Hence, the aim of the present study was to elucidate the demographic profile of applicants to the Body Donation Program (BDP) at the Federal University of Health Sciences of Porto Alegre in Brazil, as well as to assess whether the observed characteristics of body donors are unique to that sample, or if they merely reflect the characteristics of the regional population...
March 6, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28258584/biomineralization-of-calcium-carbonate-in-the-cell-wall-of-lithothamnion-crispatum-hapalidiales-rhodophyta-correlation-between-the-organic-matrix-and-the-mineral-phase
#17
Rodrigo Tomazetto de Carvalho, Leonardo Tavares Salgado, Gilberto Menezes Amado Filho, Rachel Nunes Leal, Jacques Werckmann, André Linhares Rossi, Andrea Porto Carreiro Campos, Cláudia Santiago Karez, Marcos Farina
Over the past few decades, progress has been made toward understanding the mechanisms of coralline algae mineralization. However, the relationship between the mineral phase and the organic matrix in coralline algae has not yet been thoroughly examined. The aim of this study was to describe the cell wall ultrastructure of Lithothamnion crispatum, a cosmopolitan rhodolith-forming coralline alga species collected near Salvador (Brazil), and examine the relationship between the organic matrix and the nucleation and growth/shape modulation of CaCO3 crystals...
March 4, 2017: Journal of Phycology
https://www.readbyqxmd.com/read/28257220/can-tooth-preparation-design-affect-the-fit-of-cad-cam-restorations
#18
Renato Cassio Roperto, Marina Piolli Oliveira, Thiago Soares Porto, Lais Alaberti Ferreira, Lucas Simino Melo, Anna Akkus
OBJECTIVE: The purpose of this study was to evaluate if the marginal fit of computer-aided design and computer-aided manufacturing (CAD/CAM) restorations manufactured with CAD/CAM systems can be affected by different tooth preparation designs. METHODS: Twenty-six typodont (plastic) teeth were divided into two groups (n = 13) according to the occlusal curvature of the tooth preparation. These were the group 1 (control group) (flat occlusal design) and group 2 (curved occlusal design)...
March 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28253032/validation-of-a-single-question-for-the-evaluation-of-physical-activity-in-adolescents
#19
Alexandre Magalhães, Milton Severo, Roseanne Autran, Joana Araújo, Paula Santos, Maria Fátima Pina, Elisabete Ramos
We aimed to assess the validity of a single question to evaluate leisure-time physical activity (PA) in adolescents. We included 209 participants (57.4% girls) aged 14 to 18 years from Porto, Portugal, evaluated as part of the SALTA project. A self-reported question with four answer options, designed for the EPITeen study, was used to classify the intensity level of usual leisure-time activities. Actigraph accelerometers were used to objectively measure total PA during 7 consecutive days. Since the accelerometers measured PA as a continuous variable, hierarchical cluster analysis was used to identify clusters of individuals with similar level of objectively measured PA...
March 2, 2017: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/28251446/atorvastatin-and-simvastatin-promoted-mouse-lung-repair-after-cigarette-smoke-induced-emphysema
#20
Vanessa Pinho-Ribeiro, Adriana Correa Melo, Emanuel Kennedy-Feitosa, Adriane Graca-Reis, Marina Valente Barroso, Isabella Cattani-Cavalieri, Giovanna Marcella Cavalcante Carvalho, Walter Araújo Zin, Luis Cristóvão Porto, Lycia Brito Gitirana, Manuella Lanzetti, Samuel Santos Valença
Cigarette smoke (CS) induces pulmonary emphysema by inflammation, oxidative stress, and metalloproteinase (MMP) activation. Pharmacological research studies have not focused on tissue repair after the establishment of emphysema but have instead focused on inflammatory stimulation. The aim of our study was to analyze the effects of atorvastatin and simvastatin on mouse lung repair after emphysema caused by CS. Male mice (C57BL/6, n = 45) were divided into the following groups: control (sham-exposed), CSr (mice exposed to 12 cigarettes a day for 60 days and then treated for another 60 days with the vehicle), CSr+A (CSr mice treated with atorvastatin for 60 days), and CSr+S (CSr mice treated with simvastatin for 60 days)...
March 1, 2017: Inflammation
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