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Porto study

Geilson Lima Santana, Bruno Mendonca Coelho, Yuan-Pang Wang, Alexandre Dias Porto Chiavegatto Filho, Maria Carmen Viana, Laura Helena Andrade
INTRODUCTION: Most studies on the epidemiology of personality disorders (PDs) have been conducted in high-income countries and may not represent what happens in most part of the world. In the last decades, population growth has been concentrated in low- and middle-income countries, with rapid urbanization, increasing inequalities and escalation of violence. Our aim is to estimate the prevalence of PDs in the Sao Paulo Metropolitan Area, one of the largest megacities of the world. We examined sociodemographic correlates, the influence of urban stressors, the comorbidity with other mental disorders, functional impairment and treatment...
2018: PloS One
Giovanni Luigi De Maria, Mohammad Alkhalil, Mathias Wolfrum, Gregor Fahrni, Alessandra Borlotti, Lisa Gaughran, Sam Dawkins, Jeremy P Langrish, Andrew J Lucking, Robin P Choudhury, Italo Porto, Filippo Crea, Erica Dall'Armellina, Keith M Channon, Rajesh K Kharbanda, Adrian P Banning
OBJECTIVES: This study aimed to compare the value of the index of microcirculatory resistance (IMR) and microvascular obstruction (MVO) measured by cardiac magnetic resonance (CMR) in patients treated for and recovering from ST-segment elevation myocardial infarction. BACKGROUND: IMR can identify patients with microvascular dysfunction acutely after primary percutaneous coronary intervention (pPCI), and a threshold of >40 has been shown to be associated with an adverse clinical outcome...
April 14, 2018: JACC. Cardiovascular Imaging
Rebeca Gonçalves de Melo, Alexsandra Frazão de Andrade, Raquel Pedrosa Bezerra, Dominick Spindola Correia, Vanessa Cristina de Souza, Ana Christina Brasileiro-Vidal, Daniela de Araújo Viana Marques, Ana Lúcia Figueiredo Porto
Algal wastewater remediation has become attractive for a couple of years now, however the effectiveness of genetic toxicity reducing of some by-products through microalgae are still not well reported. This study aimed to evaluate the growth, nutrients and toxicity removal of Chlorella vulgaris cultivated under autotrophic and mixotrophic conditions in three agro-industrial by-products. Mixotrophic culture using corn steep liquor showed higher cell concentration, specific growth rate, maximum cell productivity and biomass protein content when compared to cheese whey and vinasse...
April 16, 2018: Chemosphere
Davide De Rocco, Barbara Pompili, Stefano Castellani, Elena Morini, Luca Cavinato, Giuseppe Cimino, Maria A Mariggiò, Simone Guarnieri, Massimo Conese, Paola Del Porto, Fiorentina Ascenzioni
Improving the efficacy of gene therapy vectors is still an important goal toward the development of safe and efficient gene therapy treatments. S/MAR (scaffold/matrix attached region)-based vectors are maintained extra-chromosomally in numerous cell types, which is similar to viral-based vectors. Additionally, when established as an episome, they show a very high mitotic stability. In the present study we tested the idea that addition of an S/MAR element to a CFTR (cystic fibrosis transmembrane conductance regulator) expression vector, may allow the establishment of a CFTR episome in bronchial epithelial cells...
April 17, 2018: International Journal of Molecular Sciences
Isabel Cristina de Oliveira Arrieira, Maira Buss Thofehrn, Adrize Rutz Porto, Pedro Márlon Martter Moura, Caroline Lemos Martins, Michelle Barboza Jacondino
Objective To understand the experience of spirituality in the daily routine of a palliative care interdisciplinary team. Method A qualitative study was conducted with an oncological palliative care team in southern Brazil. The data was collected through phenomenological interviews in 2014, and interpreted using a hermeneutic phenomenological approach. Results Six professionals participated in the study. Spiritually-related activities, such as prayer and providing comprehensive care, were useful therapeutic resources for offering comfort, survival with dignity and humanization of death, in addition to helping the team and patients understand the end-of-life process and search for meaning in the suffering caused by illness...
2018: Revista da Escola de Enfermagem da U S P
M I de Holanda, T Matuck, D D B M de Carvalho, E M F L Domingues, R Curvo, D S Glasberg, A M G Santos, Á M Borela, L C Pôrto
BACKGROUND: Pretransplantation soluble CD30 (sCD30) has been shown to be a good predictor of acute rejection (AR) and graft loss. This study aimed to evaluate the effectiveness of sCD30 measured pretransplant and up to 6 months after transplantation as a predictor of AR, graft loss, and survival at 5 years post-transplantation. Subjects were patients receiving living donor renal transplants at Bonsucesso Federal Hospital (Rio de Janeiro) in 2006 and between August 2010 and May 2011. METHODS: sCD30 was analyzed in samples collected pretransplantation and 7, 14, and 21, 28 days and 3, 4, 5, and 6 months post-transplantation from 73 kidney recipients...
April 2018: Transplantation Proceedings
Manuela M Moreira, M Fátima Barroso, João Vasconcellos Porto, M J Ramalhosa, Jaroslava Švarc-Gajić, Letícia Estevinho, Simone Morais, Cristina Delerue-Matos
Since annually a high amount of wastes is produced in vine pruning, the aim of this study was to evaluate the potential of vine shoots from two Portuguese grape varieties (Touriga Nacional - TN and Tinta Roriz - TR) to be used as a natural source of phenolic compounds. To reach this goal, three techniques were explored, namely microwave-assisted extraction (MAE), subcritical water extraction (SWE) and conventional extraction (CE). The phenolic composition of the extracts, antioxidant and biological activities were evaluated by spectrophotometry and chromatography...
April 10, 2018: Science of the Total Environment
Miguel Sá Breda, Joaquim Castro Silva, Eurico Monteiro
OBJECTIVE: To analyze the impact of infectious complications and microbiology in the postoperative period after major oncologic neck surgeries. METHODS: A retrospective study conducted in an oncology center, including all the consecutive patients who developed infectious complications after major neck cancer surgery, from October 2012 to May 2016 (44 months). Among other data, we collected TNM stage, ASA score, body mass index, comorbidities and habits, pre and postoperative hemoglobin levels, albumin serum levels, pre-surgical treatments, length of inpatient stay, isolated microbiological agents and the recorded complications and mortality rate...
April 3, 2018: Acta Otorrinolaringológica Española
Júnior Mário Baltazar de Oliveira, Tatiana Rozental, Elba Regina Sampaio de Lemos, Danielle Forneas, Luis Miguel Ortega-Mora, Wagnner José Nascimento Porto, Andréa Alice da Fonseca Oliveira, Rinaldo Aparecido Mota
Coxiella burnetii, an intracellular bacterium, is the agent of Q fever/coxiellosis, a worldwide zoonosis. Dairy animals are the primary reservoirs of C. burnetii, and although the disease is usually asymptomatic or subclinical, abortion is a serious clinical outcome among small ruminants. This study was conducted to investigate C. burnetii seroprevalence and infection In a flock of dairy goats in Brazil. Serum samples from 312 goats collected from a dairy goat flock with a history of reproductive failure were tested by a commercial ELISA (LSIVet Ruminant Q Fever - Serum/Milk; Thermo Fisher Scientific, Lissieu, France) for anti-C...
April 3, 2018: Acta Tropica
Maria J Costa, Maria T Herdeiro, Jorge J Polónia, Inês Ribeiro-Vaz, Cármen Botelho, Eunice Castro, Josefina Cernadas
Objective: Characterization of the adverse drug reactions (ADR) reported by the immunoallergology department (IAD), Centro Hospitalar de São João (Porto), to the Northern Pharmacovigilance Centre (NPC). Methods: An observational, descriptive and retrospective study was conducted, based in a spontaneous report system. Participants were all the patients from the IAD, with suspected ADR, reported to NPC by specialists after the study was completed. Results: Studied population had a median age of 41 years, with the predominance of the female gender (73...
January 2018: Pharmacy Practice
Quan H Nguyen, Ross L Tellam, Marina Naval-Sanchez, Laercio R Porto-Neto, William Barendse, Antonio Reverter, Benjamin Hayes, James Kijas, Brian P Dalrymple
Genome sequences for hundreds of mammalian species are available, but an understanding of their genomic regulatory regions, which control gene expression, is only beginning. A comprehensive prediction of potential active regulatory regions is necessary to functionally study the roles of the majority of genomic variants in evolution, domestication, and animal production. We developed a computational method to predict regulatory DNA sequences (promoters, enhancers, and transcription factor binding sites) in production animals (cows and pigs) and extended its broad applicability to other mammals...
March 1, 2018: GigaScience
Marcelo Benedito Menezes, Kassem Samir Saleh, Marianne Yumi Nakai, Lucas Porto Maurity Dias, Norberto Kodi Kavabata, Antônio José Gonçalves
OBJECTIVE: to evaluate the results of the use of the pectoralis major flap in the reconstruction of head and neck surgeries. METHODS: we conducted a retrospective study with data bank analysis and review of medical records of patients with head and neck cancer operated at the Discipline of Head and Neck Surgery, Surgery Department, São Paulo Holy Home of Mercy, using the pectoralis major flap for reconstruction, in a period of 16 years. We analyzed age, gender, primary site of neoplasia, clinical staging, preoperative radiotherapy (RT) and complications, classified as major and minor...
March 29, 2018: Revista do Colégio Brasileiro de Cirurgiões
Cristine Maria Warmling, Ananyr Porto Fajardo, Dagmar Estermann Meyer, Cristophe Bedos
The study's main objective is to analyze how discourses of medicalization and humanization reconnect in primary healthcare and shape prenatal care for pregnant women provided by family health teams. This was a single and integrated case study with multiple analytical units and a qualitative approach. A total of 17 focus groups were performed, in which 47 health professionals were heard (14 physicians, 19 nurses, and 14 dentists), members of 17 family health teams in 16 municipalities in the South of Brazil...
March 29, 2018: Cadernos de Saúde Pública
S Tritt, N Hillenbrand, K Liesirova, G Moein, M Kieslich, L Porto
OBJECTIVE: In NF 1 patients, significant numbers of so-called unidentified bright objects (UBOs) can be found. The aim of the study was to investigate whether the detectability of UBOs increases at 3T by comparing Proton density-weighted images (PDw) with fluid-attenuated inversion recovery (FLAIR) sequences. PATIENTS AND METHODS: A total of 14 NF1 patients (7 male, 7 female, between 8 and 26 years old, mean age 15.4 years) were examined by a 3T magnetic resonance scanner...
March 2, 2018: European Journal of Paediatric Neurology: EJPN
Juliana Paludo Vallandro, Luciana da Silveira Klein Campos, Laura Dresch Neumann, Elza Daniel de Mello
BACKGROUND & AIMS: The adductor pollicis muscle thickness (APMT) is a promising method for evaluation of muscle loss and, consequently, malnutrition in adult and elderly patients. However, to date, there have been no studies of its applicability to the pediatric population. Within this context, we sought to evaluate the association of APMT with anthropometric variables, body mass index (BMI), pediatric Subjective Global Assessment (SGA) of nutrition, nutritional screening, and clinical outcomes in hospitalized pediatric patients...
February 16, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Francisco Wilker Mustafa Gomes Muniz, Ricardo Dos Santos Araújo Costa, Juliano Cavagni, Fernanda Carpes Milanesi, Juliana Balbinot Hilgert, Sabrina Carvalho Gomes, Rui Vicente Oppermann, Cassiano Kuchenbecker Rösing
BACKGROUND: This cross-sectional study aimed to evaluate the association between body mass index (BMI) and body fat with gingivitis in 613 adults of Porto Alegre, Brazil. METHODS: Individuals with at least four teeth were included in this study. They were identified through a multi-stage probability sampling, considering the city distribution of sex and age. Structured interviews were conducted by trained researchers in order to collect sociodemographic characteristics, behavioral habits, and systemic impaired conditions...
February 10, 2018: Journal of Periodontology
Hegger M Fritsch, Sabrina E M Almeida, Aguinaldo R Pinto, Tiago Gräf
CRF31_BC is an HIVs-1 recombinant form very prevalent in the southernmost capital city of Brazil, Porto Alegre. Recent studies have been describing a growing number of cases of infection by CRF31_BC in other Brazilian cities and countries, suggesting a process of expansion of this strain. Aiming to describe the city of origin, dispersion routes and demographic history of CRF31_BC, this study analyzed all HIV-1 CRF31_BC and Brazilian BC mosaic publicly available sequences. CRF31_BC classification was performed by bootscanning and tree reconstruction methods...
March 27, 2018: Infection, Genetics and Evolution
Paul Adams, Albert Altes, Pierre Brissot, Barbara Butzeck, Ioav Cabantchik, Rodolfo Cançado, Sonia Distante, Patricia Evans, Robert Evans, Tomas Ganz, Domenico Girelli, Rolf Hultcrantz, Gordon McLaren, Ben Marris, Nils Milman, Elizabeta Nemeth, Peter Nielsen, Brigitte Pineau, Alberto Piperno, Graça Porto, Dianne Prince, John Ryan, Mayka Sanchez, Paulo Santos, Dorine Swinkels, Emerência Teixeira, Ketil Toska, Annick Vanclooster, Desley White
Although guidelines are available for hereditary hemochromatosis, a high percentage of the recommendations within them are not shared between the different guidelines. Our main aim is to provide an objective, simple, brief, and practical set of recommendations about therapeutic aspects of HFE hemochromatosis for p.Cys282Tyr (C282Y/C282Y) homozygous genotype, based on the published scientific studies and guidelines, in a form that is reasonably comprehensible to patients and people without medical training. This final version was approved at the Hemochromatosis International meeting on 12th May 2017 in Los Angeles...
March 27, 2018: Hepatology International
Michael J Maroney, Robert J Hondal
This review highlights the contributions of Jean Chaudière to the field of selenium biochemistry. Chaudière was the first to recognize that one of the main reasons that selenium in the form of selenocysteine is used in proteins is due to the fact that it strongly resists permanent oxidation. The foundations for this important concept was laid down by Al Tappel in the 1960's and even before by others. The concept of oxygen tolerance first recognized in the study of glutathione peroxidase was further advanced and refined by those studying [NiFeSe]-hydrogenases, selenosubtilisin, and thioredoxin reductase...
March 24, 2018: Free Radical Biology & Medicine
Francisco M Salzano
After a brief introduction about the factors that are involved in science development, and world and Brazilian evolutionary genetics, the studies developed in Porto Alegre in this area were reviewed. Four periods in the development of this group were distinguished: (a) Origins and first expansion (1949-1961); (b) Second expansion (1962-1988); (c) Third expansion (1989-2001); and (d) The last 15 years (2002-present). The international Porto Alegre Biological Evolution Workshops (PABEWs), with five biannual events from 2007 o 2015, were also mentioned...
March 19, 2018: Genetics and Molecular Biology
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