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https://www.readbyqxmd.com/read/28214543/theoretical-structural-characterization-of-lymphoguanylin-a-potential-candidate-for-the-development-of-drugs-to-treat-gastrointestinal-disorders
#1
Állan S Pires, William F Porto, Pryscilla O Castro, Octavio L Franco, Sérgio A Alencar
Guanylin peptides (GPs) are small cysteine-rich peptide hormones involved in salt absorption, regulation of fluids and electrolyte homeostasis. This family presents four members: guanylin (GN), uroguanylin (UGN), lymphoguanylin (LGN) and renoguanylin (RGN). GPs have been used as templates for the development of drugs for the treatment of gastrointestinal disorders. Currently, LGN is the only GP with just one disulfide bridge, making it a remarkable member of this family and a potential drug template; however, there is no structural information about this peptide...
February 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28212135/the-role-of-residual-intrastent-thrombus-during-primary-angioplasty-insights-from-the-coctail-ii-study
#2
Laura Gatto, Enrico Romagnoli, Francesco Versaci, Ugo Limbruno, Tomasz Pawlowski, Italo Porto, Valeria Marco, Luca Di Vito, Fabrizio Imola, Alberto Cremonesi, Francesco Prati
AIMS: Recent frequency-domain optical coherence tomography studies showed that a complete removal of thrombotic materials is rarely achieved after percutaneous coronary interventions for ST segment elevation myocardial infarction. Residual intrastent thrombus can embolize distally leading to microcirculatory injury. The aim was to find a possible correlation between residual intrastent thrombus and angiographic indexes of myocardial reperfusion. METHODS: The population consisted of 128 ST segment elevation myocardial infarction patients enrolled in the COCTAIL II trial...
February 15, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28203420/the-diagnostic-yield-and-complications-of-open-lung-biopsies-in-kidney-transplant-patients-with-pulmonary-disease
#3
Daniere Yurie Vieira Tomotani, Antônio Tonete Bafi, Eduardo Souza Pacheco, Tainá Veras de Sandes-Freitas, Laila Almeida Viana, Edgar Porto de Oliveira Pontes, Nikkei Tamura, Hélio Tedesco-Silva, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas
BACKGROUND: The purpose of this study was to assess the efficacy of open lung biopsy (OLB) in determining the specific diagnosis and the related complications in patients with undiagnosed diffuse pulmonary infiltrates. METHODS: This single center, retrospective study included adult kidney transplant patients who underwent OLB. The patients had diffuse pulmonary infiltrates without definitive diagnoses and failed to respond to empiric antibiotic treatment. We analyzed the number of specific diagnoses, changes in treatment and the occurrence of complications in these patients...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28202024/who-cone-bio-assays-of-classical-and-new-generation-long-lasting-insecticidal-nets-call-for-innovative-insecticides-targeting-the-knock-down-resistance-mechanism-in-benin
#4
Marius Allossogbe, Virgile Gnanguenon, Boulais Yovogan, Bruno Akinro, Rodrigue Anagonou, Fiacre Agossa, André Houtoukpe, Germain Gil Padonou, Martin Akogbeto
BACKGROUND: To increase the effectiveness of insecticide-treated nets (ITN) in areas of high resistance, new long-lasting insecticidal nets (LLINs) called new-generation nets have been developed. These nets are treated with the piperonyl butoxide (PBO) synergist which inhibit the action of detoxification enzymes. The effectiveness of the new-generation nets has been proven in some studies, but their specific effect on mosquitoes carrying detoxification enzymes and those carrying both detoxification enzymes and the knock-down resistance gene in Benin is not well known...
February 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28193291/meteorological-variables-and-mosquito-monitoring-are-good-predictors-for-infestation-trends-of-aedes-aegypti-the-vector-of-dengue-chikungunya-and-zika
#5
Danielle Andreza da Cruz Ferreira, Carolin Marlen Degener, Cecilia de Almeida Marques-Toledo, Maria Mercedes Bendati, Liane Oliveira Fetzer, Camila P Teixeira, Álvaro Eduardo Eiras
BACKGROUND: Aedes aegypti is an important vector for arboviroses and widely distributed throughout the world. Climatic factors can influence vector population dynamics and, consequently, disease transmission. The aim of this study was to characterize the temporal dynamics of an Ae. aegypti population and dengue cases and to investigate the relationship between meteorological variables and mosquito infestation. METHODS: We monitored and analyzed the adult female Ae...
February 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28180928/safety-and-efficacy-of-sodium-tetradecyl-sulfate-and-lipiodol-foam-in-balloon-occluded-retrograde-transvenous-obliteration-brto-for-large-porto-systemic-shunts
#6
Amar Mukund, Ganesh Deogaonkar, S Rajesh, Saggerre Muralikrishna Shasthry, Shiv Kumar Sarin
OBJECTIVE: To evaluate the safety and efficacy sodium tetradecyl sulfate and lipiodol foam (STS foam) in BRTO for large (caliber ≥15 mm) porto-systemic shunt and gastric fundal varices. MATERIALS AND METHODS: It is a retrospective record-based study of patients who underwent BRTO using STS foam at the Institute of Liver and Biliary Sciences, New Delhi, for gastric variceal bleed or refractory hepatic encephalopathy (HE) who had large porto-systemic shunt (diameter ≥15 mm) with or without associated gastric varices...
February 8, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28178625/vaccinium-virgatum-fruit-extract-as-an-important-adjuvant-in-biochemical-and-behavioral-alterations-observed-in-animal-model-of-metabolic-syndrome
#7
Pathise Souto Oliveira, Marta Gazal, Natália Porto Flores, Aline Rigon Zimmer, Vitor Clasen Chaves, Flávio Henrique Reginatto, Manuella Pinto Kaster, Rejane Giacomelli Tavares, Roselia Maria Spanevello, Claiton Leoneti Lencina, Francieli Moro Stefanello
The aim of this study was to investigate the effect of blueberry (Vaccinium virgatum) fruit extract on metabolic, behavioral and oxidative stress parameters in the hippocampus and cerebral cortex of mice submitted to an experimental model of metabolic syndrome induced by a highly palatable diet (HPD). Mice C57BL/6 were divided into 4 experimental groups: (1) received standard chow and saline orally, (2) received standard chow and blueberry hydroalcoholic extract, (3) received HPD and saline orally, (4) received HPD and blueberry hydroalcoholic extract...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28175057/p302-cytomegalovirus-infection-in-pediatric-acute-severe-ulcerative-colitis-a-multicenter-case-controlled-study-from-the-pediatric-ibd-porto-group-of-espghan
#8
S Cohen, C Martinez-Vinson, M Aloi, D Turner, A Assa, L de Ridder, V M Wolters, T de Meij, P Alvisi, J Bronsky, U Kopylov
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172564/p262-evaluation-of-zinc-as-a-biomarker-of-a-complicated-course-in-paediatric-crohn-s-disease
#9
S Ben Avraham, R Sigall Boneh, N Cohen-Dolev, C Sarbagili-Shabat, A Levine, S Hussey, J Escher, J M de Carpi, R K Russell
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172468/dop037-a-model-for-prediction-of-early-surgery-and-complications-in-paediatric-crohn-s-disease-results-of-the-prospective-growth-cd-study
#10
A Levine, S Hussey, K L Kolho, M Sladek, J M de Carpi, D Turner, R K Russell, N Cohen-Dolev, J Escher
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172463/p158-pouchitis-in-paediatric-ulcerative-colitis-a%C3%A2-multicentre-longitudinal-cohort-study-from-the-porto-ibd-working-group-of-espghan
#11
C Topf-Olivestone, E Orlanski Meyer, O Ledder, M Friedman, I Dotan, L-F Hansen, A Kindermann, A Assa, K-L Kolho, S Kolaček, E Wine, C Strisciuglio, M Aloi, R Hansen, H S Winter, V M Navas-Lόpez, L de Ridder, F Smets, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172462/p278-short-and-long-term-surgical-outcomes-and-pouch-function-following-proctocolectomy-and-pouch-formation-in-paediatric-ulcerative-colitis-a-multicentre-retrospective-cohort-study-from-the-porto-ibd-working-group-of-espghan
#12
E Orlanski Meyer, C Topf-Olivestone, E Shtayer, H Tulchinsky, L-F Hansen, A Kindermann, A Assa, K-L Kolho, S Kolaček, M W Carroll, M Martinelli, M Aloi, R Hansen, H S Winter, V M Navas-Lόpez, B Weiss, N Shah, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167179/effect-of-myofascial-induction-therapy-on-post-c-section-scars-more-than-one-and-a-half-years-old-pilot-study
#13
Antonio Chamorro Comesaña, Ma Del Pilar Suárez Vicente, Tirso Docampo Ferreira, Ma Del Mar Pérez-La Fuente Varela, Ma Magdalena Porto Quintáns, Andrzej Pilat
Myofascial Induction Therapy (MIT) is a manually-applied method used in physiotherapy and focused on restoring altered fascial tissue. In a healthy body, the fascial system maintains elasticity and coordination of movements. However, injuries and their after-effects, such as scars, may reduce this tissue role, causing a dysfunction. The aim of this study is to ascertain the effect of MIT on scars which have completed the repair process in healthy individuals without any associated pathology that might affect the healing process...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28163109/strategies-for-serum-chemokine-cytokine-assessment-as-biomarkers-of-therapeutic-response-in-hcv-patients-as-a-prototype-to-monitor-immunotherapy-of-infectious-diseases
#14
Erica Godinho Menezes, Jordana Grazziela Alves Coelho-Dos-Reis, Ludmila Melo Cardoso, Ágata Lopes-Ribeiro, Juan Jonathan-Gonçalves, Marco Túlio Porto Gonçalves, Rodrigo Dias Cambraia, Eric Bassetti Soares, Luciana Diniz Silva, Vanessa Peruhype-Magalhães, Maria Rios, Caren Chancey, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rosângela Teixeira
In this study, strategies for serum biomarker assessment were developed for therapeutic monitoring of HCV patients. For this purpose, serum chemokine/cytokine levels were measured by cytometric-bead-array in HCV patients, categorized according to immunotherapy response as: non-responder/NR, relapser/REL and sustained-virologic-responder/SVR. The results demonstrated an overall increase of serum chemokine/cytokine levels in HCV patients. In general, therapeutic failure was associated with presence of a predominant baseline proinflammatory pattern with enhanced CCL5/RANTES, IFN-α, IFN-γ along with decreased IL-10 levels in NR and increased IL-6 and TNF in REL...
February 2, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28158252/physiological-responses-and-external-validity-of-a-new-setting-for-taekwondo-combat-simulation
#15
Matheus Hausen, Pedro Paulo Soares, Marcus Paulo Araújo, Flávia Porto, Emerson Franchini, Craig Alan Bridge, Jonas Gurgel
Combat simulations have served as an alternative framework to study the cardiorespiratory demands of the activity in combat sports, but this setting imposes rule-restrictions that may compromise the competitiveness of the bouts. The aim of this study was to assess the cardiorespiratory responses to a full-contact taekwondo combat simulation using a safe and externally valid competitive setting. Twelve male national level taekwondo athletes visited the laboratory on two separate occasions. On the first visit, anthropometric and running cardiopulmonary exercise assessments were performed...
2017: PloS One
https://www.readbyqxmd.com/read/28157671/can-wheat-germ-have-a-beneficial-effect-on-human-health-a-study-protocol-for-a-randomised-crossover-controlled-trial-to-evaluate-its-health-effects
#16
André Moreira-Rosário, Helder Pinheiro, Conceição Calhau, Luís Filipe Azevedo
INTRODUCTION: Cardiovascular diseases (CVD) are the leading cause of mortality worldwide and diet is an important contributor to CVD risk. Thus, several food derivatives are being investigated for their beneficial impact on reducing cardiometabolic risk factors, either in risk groups or in healthy population as a preventive measure. Wheat germ is a food by-product with high nutritional value, especially as a concentrated source of dietary fibre and essential fatty acids, but its incorporation into the diet has been rare up to now...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28144391/impact-of-transjugular-intrahepatic-porto-systemic-shunt-on-post-liver-transplantation-outcomes-study-based-on-the-united-network-for-organ-sharing-database
#17
Khalid Mumtaz, Sherif Metwally, Rohan M Modi, Nishi Patel, Dmitry Tumin, Anthony J Michaels, James Hanje, Ashraf El-Hinnawi, Don Hayes, Sylvester M Black
AIM: To determine the impact of transjugular intrahepatic porto-systemic shunt (TIPS) on post liver transplantation (LT) outcomes. METHODS: Utilizing the United Network for Organ Sharing (UNOS) database, we compared patients who underwent LT from 2002 to 2013 who had underwent TIPS to those without TIPS for the management of ascites while on the LT waitlist. The impact of TIPS on 30-d mortality, length of stay (LOS), and need for re-LT were studied. For evaluation of mean differences between baseline characteristics for patients with and without TIPS, we used unpaired t-tests for continuous measures and χ(2) tests for categorical measures...
January 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28137398/anti-ccp-antibodies-are-not-a-marker-of-severity-in-established-rheumatoid-arthritis-a-magnetic-resonance-imaging-study
#18
Lílian Santuza Santos Porto, Wilson Campos Tavares, Dário Alves da Silva Costa, Cristina Costa Duarte Lanna, Adriana Maria Kakehasi
INTRODUCTION: The presence of anti-CCP is an important prognostic tool of rheumatoid arthritis (RA). But research is still ongoing on its relationship with disease activity and functional capacity. OBJECTIVES: To study the relationship between anti-CCP and disease activity, functional capacity and structural damage indexes, by means of conventional radiography (CR) and magnetic resonance imaging (MRI), in cases of established RA. METHODS: Cross-sectional study with RA patients with 1-10 disease duration...
January 2017: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/28135606/hla-g-variability-and-haplotypes-detected-by-massively-parallel-sequencing-procedures-in-the-geographicaly-distinct-population-samples-of-brazil-and-cyprus
#19
Erick C Castelli, Petroula Gerasimou, Michelle A Paz, Jaqueline Ramalho, Iane O P Porto, Thálitta H A Lima, Andréia S Souza, Luciana C Veiga-Castelli, Cristhianna V A Collares, Eduardo A Donadi, Celso T Mendes-Junior, Paul Costeas
The HLA-G molecule presents immunomodulatory properties that might inhibit immune responses when interacting with specific Natural Killer and T cell receptors, such as KIR2DL4, ILT2 and ILT4. Thus, HLA-G might influence the outcome of situations in which fine immune system modulation is required, such as autoimmune diseases, transplants, cancer and pregnancy. The majority of the studies regarding the HLA-G gene variability so far was restricted to a specific gene segment (i.e., promoter, coding or 3' untranslated region), and was performed by using Sanger sequencing and probabilistic models to infer haplotypes...
January 27, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28133731/the-use-of-laser-microdissection-in-forensic-sexual-assault-casework-pros-and-cons-compared-to-standard-methods
#20
Sergio Costa, Paulo Correia-de-Sá, Maria J Porto, Laura Cainé
Sexual assault samples are among the most frequently analyzed in a forensic laboratory. These account for almost half of all samples processed routinely, and a large portion of these cases remain unsolved. These samples often pose problems to traditional analytic methods of identification because they consist most frequently of cell mixtures from at least two contributors: the victim (usually female) and the perpetrator (usually male). In this study, we propose the use of current preliminary testing for sperm detection in order to determine the chances of success when faced with samples which can be good candidates to undergo analysis with the laser microdissection technology...
January 30, 2017: Journal of Forensic Sciences
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