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https://www.readbyqxmd.com/read/28214543/theoretical-structural-characterization-of-lymphoguanylin-a-potential-candidate-for-the-development-of-drugs-to-treat-gastrointestinal-disorders
#1
Állan S Pires, William F Porto, Pryscilla O Castro, Octavio L Franco, Sérgio A Alencar
Guanylin peptides (GPs) are small cysteine-rich peptide hormones involved in salt absorption, regulation of fluids and electrolyte homeostasis. This family presents four members: guanylin (GN), uroguanylin (UGN), lymphoguanylin (LGN) and renoguanylin (RGN). GPs have been used as templates for the development of drugs for the treatment of gastrointestinal disorders. Currently, LGN is the only GP with just one disulfide bridge, making it a remarkable member of this family and a potential drug template; however, there is no structural information about this peptide...
February 15, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28214080/clinical-outcome-and-correlates-of-coronary-microvascular-obstruction-in-latecomers-after-acute-myocardial-infarction
#2
Rocco A Montone, Giampaolo Niccoli, Silvia Minelli, Francesco Fracassi, Vincenzo Vetrugno, Cristina Aurigemma, Francesco Burzotta, Italo Porto, Carlo Trani, Filippo Crea
AIMS: Microvascular obstruction (MVO) is associated with a worse prognosis in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI). However, data about incidence, clinical outcome and correlates of MVO in latecomers after STEMI are still lacking. METHODS: We prospectively enrolled consecutive patients that were latecomers after STEMI (symptoms onset >12h) undergoing PCI. We performed an angiographic analysis to assess the occurrence of MVO [defined as TIMI flow grade ≤2 or 3 with a myocardial blush grade <2]...
February 12, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28212135/the-role-of-residual-intrastent-thrombus-during-primary-angioplasty-insights-from-the-coctail-ii-study
#3
Laura Gatto, Enrico Romagnoli, Francesco Versaci, Ugo Limbruno, Tomasz Pawlowski, Italo Porto, Valeria Marco, Luca Di Vito, Fabrizio Imola, Alberto Cremonesi, Francesco Prati
AIMS: Recent frequency-domain optical coherence tomography studies showed that a complete removal of thrombotic materials is rarely achieved after percutaneous coronary interventions for ST segment elevation myocardial infarction. Residual intrastent thrombus can embolize distally leading to microcirculatory injury. The aim was to find a possible correlation between residual intrastent thrombus and angiographic indexes of myocardial reperfusion. METHODS: The population consisted of 128 ST segment elevation myocardial infarction patients enrolled in the COCTAIL II trial...
February 15, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28203420/the-diagnostic-yield-and-complications-of-open-lung-biopsies-in-kidney-transplant-patients-with-pulmonary-disease
#4
Daniere Yurie Vieira Tomotani, Antônio Tonete Bafi, Eduardo Souza Pacheco, Tainá Veras de Sandes-Freitas, Laila Almeida Viana, Edgar Porto de Oliveira Pontes, Nikkei Tamura, Hélio Tedesco-Silva, Flavia Ribeiro Machado, Flávio Geraldo Rezende Freitas
BACKGROUND: The purpose of this study was to assess the efficacy of open lung biopsy (OLB) in determining the specific diagnosis and the related complications in patients with undiagnosed diffuse pulmonary infiltrates. METHODS: This single center, retrospective study included adult kidney transplant patients who underwent OLB. The patients had diffuse pulmonary infiltrates without definitive diagnoses and failed to respond to empiric antibiotic treatment. We analyzed the number of specific diagnoses, changes in treatment and the occurrence of complications in these patients...
January 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28202024/who-cone-bio-assays-of-classical-and-new-generation-long-lasting-insecticidal-nets-call-for-innovative-insecticides-targeting-the-knock-down-resistance-mechanism-in-benin
#5
Marius Allossogbe, Virgile Gnanguenon, Boulais Yovogan, Bruno Akinro, Rodrigue Anagonou, Fiacre Agossa, André Houtoukpe, Germain Gil Padonou, Martin Akogbeto
BACKGROUND: To increase the effectiveness of insecticide-treated nets (ITN) in areas of high resistance, new long-lasting insecticidal nets (LLINs) called new-generation nets have been developed. These nets are treated with the piperonyl butoxide (PBO) synergist which inhibit the action of detoxification enzymes. The effectiveness of the new-generation nets has been proven in some studies, but their specific effect on mosquitoes carrying detoxification enzymes and those carrying both detoxification enzymes and the knock-down resistance gene in Benin is not well known...
February 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28193291/meteorological-variables-and-mosquito-monitoring-are-good-predictors-for-infestation-trends-of-aedes-aegypti-the-vector-of-dengue-chikungunya-and-zika
#6
Danielle Andreza da Cruz Ferreira, Carolin Marlen Degener, Cecilia de Almeida Marques-Toledo, Maria Mercedes Bendati, Liane Oliveira Fetzer, Camila P Teixeira, Álvaro Eduardo Eiras
BACKGROUND: Aedes aegypti is an important vector for arboviroses and widely distributed throughout the world. Climatic factors can influence vector population dynamics and, consequently, disease transmission. The aim of this study was to characterize the temporal dynamics of an Ae. aegypti population and dengue cases and to investigate the relationship between meteorological variables and mosquito infestation. METHODS: We monitored and analyzed the adult female Ae...
February 13, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28188498/erratum-to-titanium-scaffold-osteogenesis-in-healthy-and-osteoporotic-rats-is-improved-by-the-use-of-low-level-laser-therapy-gaalas
#7
Luana Marotta Reis de Vasconcellos, Mary Anne Moreira Barbara, Emanuel da Silva Rovai, Mariana de Oliveira França, Zahra Fernandes Ebrahim, Luis Gustavo Oliveira de Vasconcellos, Camila Deco Porto, Carlos Alberto Alves Cairo
No abstract text is available yet for this article.
February 11, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28187674/a-new-species-of-poison-dart-frog-anura-dendrobatidae-from-manu-province-amazon-region-of-southeastern-peru-with-notes-on-its-natural-history-bioacoustics-phylogenetics-and-recommended-conservation-status
#8
Shirley J Serrano-Rojas, Andrew Whitworth, Jaime Villacampa, Rudolf VON May, Roberto C Gutiérrez, José M Padial, Juan C Chaparro
We describe and name a new species of poison-dart frog from the Amazonian slopes of the Andes in Manu Province, Madre de Dios Department, Peru; specifically within the Amarakaeri Communal Reserve and the buffer zone of Manu National Park. Ameerega shihuemoy sp. nov. is supported by a unique combination of characters: black dorsum with cream to light orange dorsolateral lines, blue belly reticulated with black, and the lack of axillary, thigh and calf flash marks. Within Ameerega, it shares the general appearance of A...
January 16, 2017: Zootaxa
https://www.readbyqxmd.com/read/28187467/protective-effects-of-ellagic-acid-on-cardiovascular-injuries-caused-by-hypertension-in-rats
#9
Juliana Bahia Reis Jordão, Hellen Karine Paes Porto, Flávio Marques Lopes, Aline Carvalho Batista, Matheus Lavorenti Rocha
Ellagic acid is described as having antioxidant and antiproliferative properties. Hence, it was hypothesized that ellagic acid could improve cardiovascular damage caused by hypertension. In this work, hypertension was induced in rats with Nω-Nitro-L-arginine methyl ester hydrochloride (60 mg/kg/day in drinking water) for 6 weeks. Ellagic acid was coadministered (10 or 30 mg/kg/day by gavage) between the second and sixth week. Blood pressure was recorded every week by tail-cuff plethysmography. After 6 weeks, the rats were sacrificed, the hearts and kidneys were weighed, and blood was collected...
February 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28181124/erratum-to-usefulness-of-combining-admission-brain-natriuretic-peptide-bnp-plus-hospital-discharge-bioelectrical-impedance-vector-analysis-biva-in-predicting-90%C3%A2-days-cardiovascular-mortality-in-patients-with-acute-heart-failure
#10
Simona Santarelli, Veronica Russo, Irene Lalle, Benedetta De Berardinis, Silvia Navarin, Laura Magrini, Antonio Piccoli, Marta Codognotto, Luigi Maria Castello, Gian Carlo Avanzi, Humberto Villacorta, Bernardo Luiz Campanário Precht, Pilar Barreto de Araújo Porto, Aline Sterque Villacorta, Salvatore Di Somma
No abstract text is available yet for this article.
February 8, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28180928/safety-and-efficacy-of-sodium-tetradecyl-sulfate-and-lipiodol-foam-in-balloon-occluded-retrograde-transvenous-obliteration-brto-for-large-porto-systemic-shunts
#11
Amar Mukund, Ganesh Deogaonkar, S Rajesh, Saggerre Muralikrishna Shasthry, Shiv Kumar Sarin
OBJECTIVE: To evaluate the safety and efficacy sodium tetradecyl sulfate and lipiodol foam (STS foam) in BRTO for large (caliber ≥15 mm) porto-systemic shunt and gastric fundal varices. MATERIALS AND METHODS: It is a retrospective record-based study of patients who underwent BRTO using STS foam at the Institute of Liver and Biliary Sciences, New Delhi, for gastric variceal bleed or refractory hepatic encephalopathy (HE) who had large porto-systemic shunt (diameter ≥15 mm) with or without associated gastric varices...
February 8, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28178625/vaccinium-virgatum-fruit-extract-as-an-important-adjuvant-in-biochemical-and-behavioral-alterations-observed-in-animal-model-of-metabolic-syndrome
#12
Pathise Souto Oliveira, Marta Gazal, Natália Porto Flores, Aline Rigon Zimmer, Vitor Clasen Chaves, Flávio Henrique Reginatto, Manuella Pinto Kaster, Rejane Giacomelli Tavares, Roselia Maria Spanevello, Claiton Leoneti Lencina, Francieli Moro Stefanello
The aim of this study was to investigate the effect of blueberry (Vaccinium virgatum) fruit extract on metabolic, behavioral and oxidative stress parameters in the hippocampus and cerebral cortex of mice submitted to an experimental model of metabolic syndrome induced by a highly palatable diet (HPD). Mice C57BL/6 were divided into 4 experimental groups: (1) received standard chow and saline orally, (2) received standard chow and blueberry hydroalcoholic extract, (3) received HPD and saline orally, (4) received HPD and blueberry hydroalcoholic extract...
February 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28175057/p302-cytomegalovirus-infection-in-pediatric-acute-severe-ulcerative-colitis-a-multicenter-case-controlled-study-from-the-pediatric-ibd-porto-group-of-espghan
#13
S Cohen, C Martinez-Vinson, M Aloi, D Turner, A Assa, L de Ridder, V M Wolters, T de Meij, P Alvisi, J Bronsky, U Kopylov
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172960/p414-vedolizumab-in-pediatric-inflammatory-bowel-diseases-a-retrospective-multi-center-experience-from-the-paediatric-ibd-porto-group-of-espghan
#14
O Ledder, T de Meij, J Martín de Carpi, L Richmond, S Cohen, J Bronsky, R Shaoul, A Levine, J Escher, L deRidder, A Assa, F Ruemmele, N Shah, V Wolters, A Rodrigues, H Uhlig, D Urlep, C Posovsky, K Kolho, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172564/p262-evaluation-of-zinc-as-a-biomarker-of-a-complicated-course-in-paediatric-crohn-s-disease
#15
S Ben Avraham, R Sigall Boneh, N Cohen-Dolev, C Sarbagili-Shabat, A Levine, S Hussey, J Escher, J M de Carpi, R K Russell
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172468/dop037-a-model-for-prediction-of-early-surgery-and-complications-in-paediatric-crohn-s-disease-results-of-the-prospective-growth-cd-study
#16
A Levine, S Hussey, K L Kolho, M Sladek, J M de Carpi, D Turner, R K Russell, N Cohen-Dolev, J Escher
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172463/p158-pouchitis-in-paediatric-ulcerative-colitis-a%C3%A2-multicentre-longitudinal-cohort-study-from-the-porto-ibd-working-group-of-espghan
#17
C Topf-Olivestone, E Orlanski Meyer, O Ledder, M Friedman, I Dotan, L-F Hansen, A Kindermann, A Assa, K-L Kolho, S Kolaček, E Wine, C Strisciuglio, M Aloi, R Hansen, H S Winter, V M Navas-Lόpez, L de Ridder, F Smets, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28172462/p278-short-and-long-term-surgical-outcomes-and-pouch-function-following-proctocolectomy-and-pouch-formation-in-paediatric-ulcerative-colitis-a-multicentre-retrospective-cohort-study-from-the-porto-ibd-working-group-of-espghan
#18
E Orlanski Meyer, C Topf-Olivestone, E Shtayer, H Tulchinsky, L-F Hansen, A Kindermann, A Assa, K-L Kolho, S Kolaček, M W Carroll, M Martinelli, M Aloi, R Hansen, H S Winter, V M Navas-Lόpez, B Weiss, N Shah, D Turner
No abstract text is available yet for this article.
February 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28167179/effect-of-myofascial-induction-therapy-on-post-c-section-scars-more-than-one-and-a-half-years-old-pilot-study
#19
Antonio Chamorro Comesaña, Ma Del Pilar Suárez Vicente, Tirso Docampo Ferreira, Ma Del Mar Pérez-La Fuente Varela, Ma Magdalena Porto Quintáns, Andrzej Pilat
Myofascial Induction Therapy (MIT) is a manually-applied method used in physiotherapy and focused on restoring altered fascial tissue. In a healthy body, the fascial system maintains elasticity and coordination of movements. However, injuries and their after-effects, such as scars, may reduce this tissue role, causing a dysfunction. The aim of this study is to ascertain the effect of MIT on scars which have completed the repair process in healthy individuals without any associated pathology that might affect the healing process...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28163109/strategies-for-serum-chemokine-cytokine-assessment-as-biomarkers-of-therapeutic-response-in-hcv-patients-as-a-prototype-to-monitor-immunotherapy-of-infectious-diseases
#20
Erica Godinho Menezes, Jordana Grazziela Alves Coelho-Dos-Reis, Ludmila Melo Cardoso, Ágata Lopes-Ribeiro, Juan Jonathan-Gonçalves, Marco Túlio Porto Gonçalves, Rodrigo Dias Cambraia, Eric Bassetti Soares, Luciana Diniz Silva, Vanessa Peruhype-Magalhães, Maria Rios, Caren Chancey, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Rosângela Teixeira
In this study, strategies for serum biomarker assessment were developed for therapeutic monitoring of HCV patients. For this purpose, serum chemokine/cytokine levels were measured by cytometric-bead-array in HCV patients, categorized according to immunotherapy response as: non-responder/NR, relapser/REL and sustained-virologic-responder/SVR. The results demonstrated an overall increase of serum chemokine/cytokine levels in HCV patients. In general, therapeutic failure was associated with presence of a predominant baseline proinflammatory pattern with enhanced CCL5/RANTES, IFN-α, IFN-γ along with decreased IL-10 levels in NR and increased IL-6 and TNF in REL...
February 2, 2017: Antiviral Research
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